<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
263
</numberChangedClasses>
<numberNewClasses>
799
</numberNewClasses>
<numberDeletedClasses>
0
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28241</classIRI>
<classLabel>Effector Immune Cell</classLabel>
<deletedAxiom>&apos;Effector Immune Cell&apos; SubClassOf &apos;Hematopoietic and Lymphoid Cell&apos;</deletedAxiom>
<newAxiom>&apos;Effector Immune Cell&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132890</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28499</classIRI>
<classLabel>Manic Fringe</classLabel>
<deletedAxiom>&apos;Manic Fringe&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MFNG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Manic Fringe&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;O-Mannosyl Glycan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MFNG Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28653</classIRI>
<classLabel>TRAF2 Gene</classLabel>
<deletedAxiom>&apos;TRAF2 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;</deletedAxiom>
<deletedAxiom>&apos;TRAF2 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</deletedAxiom>
<newAxiom>&apos;TRAF2 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Ubiquitination&apos;</newAxiom>
<newAxiom>&apos;TRAF2 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Apoptosis&apos;</newAxiom>
<newAxiom>&apos;TRAF2 Gene&apos; SubClassOf &apos;Ubiquitin Ligase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3288</classIRI>
<classLabel>Oligodendroglioma</classLabel>
<deletedAxiom>&apos;Oligodendroglioma&apos; EquivalentTo &apos;Diffuse Glioma&apos; and &apos;Low Grade Glioma&apos; and &apos;Oligodendroglial Tumor&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Diffuse Pattern&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Honeycomb Pattern&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Monomorphic Cellular Infiltrate&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Microcalcification&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 2&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 7&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 14&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 6&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 11p&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 22q&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Hemorrhage&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Mucoid Stroma Formation&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Cystic Change&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Anaplastic Lesion&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Extensive Necrosis&apos;)</deletedAxiom>
<newAxiom>&apos;Oligodendroglioma&apos; EquivalentTo &apos;Diffuse Glioma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132505 and &apos;Oligodendroglial Tumor&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Diffuse Pattern&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Honeycomb Pattern&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Monomorphic Cellular Infiltrate&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Microcalcification&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 2&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 7&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 14&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 6&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 11p&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 22q&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Hemorrhage&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Mucoid Stroma Formation&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Cystic Change&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Anaplastic Lesion&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Extensive Necrosis&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28706</classIRI>
<classLabel>BCL7A Protein</classLabel>
<deletedAxiom>&apos;BCL7A Protein&apos; SubClassOf &apos;Signaling Protein&apos;</deletedAxiom>
<newAxiom>&apos;BCL7A Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;</newAxiom>
<newAxiom>&apos;BCL7A Protein&apos; SubClassOf &apos;Transcription Regulatory Protein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28707</classIRI>
<classLabel>B-Cell Lymphoma 9 Protein</classLabel>
<deletedAxiom>&apos;B-Cell Lymphoma 9 Protein&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;B Acute Lymphoblastic Leukemia&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Small Intestine&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Blood&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Developmental Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCL9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;B-Cell Lymphoma 9 Protein&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;B Acute Lymphoblastic Leukemia&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Small Intestine&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Blood&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Developmental Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCL9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3017</classIRI>
<classLabel>Ependymoma</classLabel>
<deletedAxiom>&apos;Ependymoma&apos; EquivalentTo &apos;Low Grade Glioma&apos; and &apos;Ependymal Tumor&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Monomorphic Cellular Infiltrate&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Slow Growing Mass&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 2&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Calcification&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Anaplastic Lesion&apos;)</deletedAxiom>
<newAxiom>&apos;Ependymoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132505 and &apos;Ependymal Tumor&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Monomorphic Cellular Infiltrate&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Slow Growing Mass&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 2&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Calcification&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Anaplastic Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34094</classIRI>
<classLabel>Type II cGMP-Dependent Protein Kinase</classLabel>
<deletedAxiom>&apos;Type II cGMP-Dependent Protein Kinase&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channels in Vascular Endothelium Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKG2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Type II cGMP-Dependent Protein Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channels in Vascular Endothelium Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKG2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34098</classIRI>
<classLabel>Patched Homolog 2</classLabel>
<deletedAxiom>&apos;Patched Homolog 2&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTCH2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Patched Homolog 2&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cellular Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTCH2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48964</classIRI>
<classLabel>SIPA1 Gene</classLabel>
<deletedAxiom>&apos;SIPA1 Gene&apos; SubClassOf &apos;RAS Family Gene&apos;</deletedAxiom>
<newAxiom>&apos;SIPA1 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93035</classIRI>
<classLabel>Nonspecific Immune Cell</classLabel>
<newAxiom>&apos;Nonspecific Immune Cell&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132890</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20394</classIRI>
<classLabel>WNT Family Protein</classLabel>
<newAxiom>&apos;WNT Family Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;</newAxiom>
<newAxiom>&apos;WNT Family Protein&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20910</classIRI>
<classLabel>WNT1 Inducible Signaling Pathway Protein 1</classLabel>
<deletedAxiom>&apos;WNT1 Inducible Signaling Pathway Protein 1&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Survival&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WISP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;WNT1 Inducible Signaling Pathway Protein 1&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Survival&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WISP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20911</classIRI>
<classLabel>WISP1 Gene</classLabel>
<deletedAxiom>&apos;WISP1 Gene&apos; SubClassOf &apos;Growth Factor Gene&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20952</classIRI>
<classLabel>BAG1 Gene</classLabel>
<deletedAxiom>&apos;BAG1 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;BAG1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Protein Folding&apos;</newAxiom>
<newAxiom>&apos;BAG1 Gene&apos; SubClassOf &apos;Regulatory Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20953</classIRI>
<classLabel>BAG1 Protein</classLabel>
<deletedAxiom>&apos;BAG1 Protein&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BAG1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;BAG1 Protein&apos; EquivalentTo &apos;Apoptosis Regulator&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Inhibitor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BAG1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29587</classIRI>
<classLabel>FGFR Substrate 2</classLabel>
<deletedAxiom>&apos;FGFR Substrate 2&apos; SubClassOf &apos;Adaptor Signaling Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;FGFR Substrate 2&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FRS2 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;FGFR Substrate 2&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</deletedAxiom>
<newAxiom>&apos;FGFR Substrate 2&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FRS2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29593</classIRI>
<classLabel>Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 2</classLabel>
<newAxiom>&apos;Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 2&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;</newAxiom>
<newAxiom>&apos;Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 2&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Actin-Binding Protein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118587</classIRI>
<classLabel>Mothers Against Decapentaplegic Homolog 5</classLabel>
<deletedAxiom>&apos;Mothers Against Decapentaplegic Homolog 5&apos; EquivalentTo &apos;Transcription Factor&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Sequence-Specific DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMAD5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mothers Against Decapentaplegic Homolog 5&apos; EquivalentTo &apos;Transcription Factor&apos; and &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Sequence-Specific DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMAD5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29752</classIRI>
<classLabel>Interleukin-1 Receptor-Associated Kinase 4</classLabel>
<deletedAxiom>&apos;Interleukin-1 Receptor-Associated Kinase 4&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IRAK4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interleukin-1 Receptor-Associated Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IRAK4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29762</classIRI>
<classLabel>RAN GTPase Activating Protein 1</classLabel>
<deletedAxiom>&apos;RAN GTPase Activating Protein 1&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Import into Nucleus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitotic Spindle Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ran Cycling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleocytoplasmic Transport&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RANGAP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAN GTPase Activating Protein 1&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Import into Nucleus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitotic Spindle Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ran Cycling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RANBP2-Mediated Sumoylation Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleocytoplasmic Transport&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RANGAP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29765</classIRI>
<classLabel>Retinoic Acid Receptor Responder Protein 3</classLabel>
<deletedAxiom>&apos;Retinoic Acid Receptor Responder Protein 3&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RARRES3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Retinoic Acid Receptor Responder Protein 3&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RARRES3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29766</classIRI>
<classLabel>Activator of G-Protein Signaling 1</classLabel>
<deletedAxiom>&apos;Activator of G-Protein Signaling 1&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RASD1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Activator of G-Protein Signaling 1&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RASD1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2083</classIRI>
<classLabel>DNA Methyltransferase Inhibitor</classLabel>
<newAxiom>&apos;DNA Methyltransferase Inhibitor&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132686</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29913</classIRI>
<classLabel>RAS-Like Protein RRP22</classLabel>
<deletedAxiom>&apos;RAS-Like Protein RRP22&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RASL10A Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;RAS-Like Protein RRP22&apos; SubClassOf &apos;RAS Superfamily Protein&apos;</deletedAxiom>
<newAxiom>&apos;RAS-Like Protein RRP22&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RASL10A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29935</classIRI>
<classLabel>Semaphorin 3E</classLabel>
<deletedAxiom>&apos;Semaphorin 3E&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SEMA3E Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Semaphorin 3E&apos; SubClassOf &apos;Signaling Protein&apos;</newAxiom>
<newAxiom>&apos;Semaphorin 3E&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;</newAxiom>
<newAxiom>&apos;Semaphorin 3E&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SEMA3E Gene&apos;</newAxiom>
<newAxiom>&apos;Semaphorin 3E&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;</newAxiom>
<newAxiom>&apos;Semaphorin 3E&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29944</classIRI>
<classLabel>SH2 Domain Containing Protein 3C</classLabel>
<deletedAxiom>&apos;SH2 Domain Containing Protein 3C&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Adaptor Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SH2D3C Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SH2 Domain Containing Protein 3C&apos; SubClassOf &apos;Adaptor Signaling Protein&apos;</newAxiom>
<newAxiom>&apos;SH2 Domain Containing Protein 3C&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
<newAxiom>&apos;SH2 Domain Containing Protein 3C&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SH2D3C Gene&apos;</newAxiom>
<newAxiom>&apos;SH2 Domain Containing Protein 3C&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29942</classIRI>
<classLabel>SH2-B Homolog</classLabel>
<deletedAxiom>&apos;SH2-B Homolog&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Adaptor Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SH2B1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SH2-B Homolog&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SH2B1 Gene&apos;</newAxiom>
<newAxiom>&apos;SH2-B Homolog&apos; SubClassOf &apos;Adaptor Signaling Protein&apos;</newAxiom>
<newAxiom>&apos;SH2-B Homolog&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;</newAxiom>
<newAxiom>&apos;SH2-B Homolog&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
<newAxiom>&apos;SH2-B Homolog&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29978</classIRI>
<classLabel>SHC Transforming Protein 2</classLabel>
<deletedAxiom>&apos;SHC Transforming Protein 2&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SHC2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SHC Transforming Protein 2&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SHC2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29996</classIRI>
<classLabel>Spectrin SH3 Domain Binding Protein 1</classLabel>
<deletedAxiom>&apos;Spectrin SH3 Domain Binding Protein 1&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Adaptor Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ABI1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Spectrin SH3 Domain Binding Protein 1&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Stabilization Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ABI1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88987</classIRI>
<classLabel>Catenin Alpha-1</classLabel>
<deletedAxiom>&apos;Catenin Alpha-1&apos; SubClassOf &apos;Adaptor Signaling Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;Catenin Alpha-1&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CTNNA1 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;Catenin Alpha-1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;</deletedAxiom>
<deletedAxiom>&apos;Catenin Alpha-1&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Catenin Family Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;Catenin Alpha-1&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Zonula Adherens&apos;</deletedAxiom>
<newAxiom>&apos;Catenin Alpha-1&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Zonula Adherens&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Catenin Family Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CTNNA1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21015</classIRI>
<classLabel>Deleted In Bladder Cancer Protein 1</classLabel>
<deletedAxiom>&apos;Deleted In Bladder Cancer Protein 1&apos; SubClassOf &apos;Adaptor Signaling Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;Deleted In Bladder Cancer Protein 1&apos; SubClassOf &apos;Apoptosis Regulator&apos;</deletedAxiom>
<newAxiom>&apos;Deleted In Bladder Cancer Protein 1&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;</newAxiom>
<newAxiom>&apos;Deleted In Bladder Cancer Protein 1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;</newAxiom>
<newAxiom>&apos;Deleted In Bladder Cancer Protein 1&apos; SubClassOf &apos;Cell Cycle Protein&apos;</newAxiom>
<newAxiom>&apos;Deleted In Bladder Cancer Protein 1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Cell Death&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21249</classIRI>
<classLabel>WNT-10B Protein</classLabel>
<deletedAxiom>&apos;WNT-10B Protein&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Adipogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT10B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;WNT-10B Protein&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Adipogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT10B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21340</classIRI>
<classLabel>RAS Homolog Gene Family Member H Protein</classLabel>
<deletedAxiom>&apos;RAS Homolog Gene Family Member H Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Hematopoietic Stem Cell&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOH Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAS Homolog Gene Family Member H Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Hematopoietic Stem Cell&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOH Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21447</classIRI>
<classLabel>WNT1 Inducible Signaling Pathway Protein 3</classLabel>
<deletedAxiom>&apos;WNT1 Inducible Signaling Pathway Protein 3&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WISP3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;WNT1 Inducible Signaling Pathway Protein 3&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WISP3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21449</classIRI>
<classLabel>WNT6 Protein</classLabel>
<deletedAxiom>&apos;WNT6 Protein&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGD Motif&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;N-Glycosylation Site&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Signal Peptide&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Fate Control&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;WNT6 Protein&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGD Motif&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;N-Glycosylation Site&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Signal Peptide&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Fate Control&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21444</classIRI>
<classLabel>VAV3 Protein</classLabel>
<deletedAxiom>&apos;VAV3 Protein&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Acidic Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;VAV3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;VAV3 Protein&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Acidic Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;VAV3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21450</classIRI>
<classLabel>WNT10A Protein</classLabel>
<deletedAxiom>&apos;WNT10A Protein&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Fate Control&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nervous System Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT10A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;WNT10A Protein&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Fate Control&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nervous System Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT10A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21451</classIRI>
<classLabel>Protein Wnt-11</classLabel>
<deletedAxiom>&apos;Protein Wnt-11&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Striated Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Fate Control&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT11 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein Wnt-11&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Striated Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Fate Control&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT11 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21473</classIRI>
<classLabel>TRAT1 Gene</classLabel>
<deletedAxiom>&apos;TRAT1 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;TRAT1 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21474</classIRI>
<classLabel>TRIO Gene</classLabel>
<newAxiom>&apos;TRIO Gene&apos; SubClassOf &apos;Serine/Threonine Protein Kinase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21476</classIRI>
<classLabel>TRIP10 Gene</classLabel>
<deletedAxiom>&apos;TRIP10 Gene&apos; SubClassOf &apos;Ligand Binding Protein Gene&apos;</deletedAxiom>
<newAxiom>&apos;TRIP10 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21488</classIRI>
<classLabel>Axin-2</classLabel>
<deletedAxiom>&apos;Axin-2&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DIX Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Armadillo Repeat&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;GSK-Binding Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AXIN2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Axin-2&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DIX Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Armadillo Repeat&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;GSK-Binding Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AXIN2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21491</classIRI>
<classLabel>Breast Cancer Anti-Estrogen Resistance 1 Protein</classLabel>
<deletedAxiom>&apos;Breast Cancer Anti-Estrogen Resistance 1 Protein&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Helix-Loop-Helix Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;YDYVHL Motif&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;YXXP Motif&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Proline-Rich Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2-Binding Motif&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCAR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Breast Cancer Anti-Estrogen Resistance 1 Protein&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell to Cell Adhesion Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endothelin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTP4A Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Helix-Loop-Helix Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;YDYVHL Motif&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;YXXP Motif&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Proline-Rich Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2-Binding Motif&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Scaffolding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCAR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21511</classIRI>
<classLabel>Epithelial Stromal Interaction 1</classLabel>
<newAxiom>&apos;Epithelial Stromal Interaction 1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;</newAxiom>
<newAxiom>&apos;Epithelial Stromal Interaction 1&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21537</classIRI>
<classLabel>WNT4 Protein</classLabel>
<deletedAxiom>&apos;WNT4 Protein&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Fate Control&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;WNT4 Protein&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Fate Control&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16108</classIRI>
<classLabel>Population-Based Registry</classLabel>
<deletedAxiom>&apos;Population-Based Registry&apos; SubClassOf &apos;Cancer Registry&apos;</deletedAxiom>
<newAxiom>&apos;Population-Based Registry&apos; SubClassOf &apos;Population Database&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16554</classIRI>
<classLabel>Enzyme</classLabel>
<newAxiom>&apos;Enzyme&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Substrate Domain&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5897</classIRI>
<classLabel>Stage III Major Salivary Gland Carcinoma</classLabel>
<deletedAxiom>&apos;Stage III Major Salivary Gland Carcinoma&apos; EquivalentTo &apos;Major Salivary Gland Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage III&apos;)</deletedAxiom>
<newAxiom>&apos;Stage III Major Salivary Gland Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132778 and (&apos;Disease_Is_Stage&apos; some &apos;Stage III&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5896</classIRI>
<classLabel>Stage II Major Salivary Gland Carcinoma</classLabel>
<deletedAxiom>&apos;Stage II Major Salivary Gland Carcinoma&apos; EquivalentTo &apos;Major Salivary Gland Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage II&apos;)</deletedAxiom>
<newAxiom>&apos;Stage II Major Salivary Gland Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132778 and (&apos;Disease_Is_Stage&apos; some &apos;Stage II&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5898</classIRI>
<classLabel>Stage IV Major Salivary Gland Carcinoma</classLabel>
<deletedAxiom>&apos;Stage IV Major Salivary Gland Carcinoma&apos; EquivalentTo &apos;Major Salivary Gland Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage IV&apos;)</deletedAxiom>
<newAxiom>&apos;Stage IV Major Salivary Gland Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132778 and (&apos;Disease_Is_Stage&apos; some &apos;Stage IV&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5895</classIRI>
<classLabel>Stage I Major Salivary Gland Carcinoma</classLabel>
<deletedAxiom>&apos;Stage I Major Salivary Gland Carcinoma&apos; EquivalentTo &apos;Major Salivary Gland Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage I&apos;)</deletedAxiom>
<newAxiom>&apos;Stage I Major Salivary Gland Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132778 and (&apos;Disease_Is_Stage&apos; some &apos;Stage I&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C107454</classIRI>
<classLabel>GAB1 Gene</classLabel>
<deletedAxiom>&apos;GAB1 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;GAB1 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C107456</classIRI>
<classLabel>GRB2-Associated-Binding Protein 1</classLabel>
<deletedAxiom>&apos;GRB2-Associated-Binding Protein 1&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GAB1 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;GRB2-Associated-Binding Protein 1&apos; SubClassOf &apos;Signaling Protein&apos;</deletedAxiom>
<newAxiom>&apos;GRB2-Associated-Binding Protein 1&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Proline-Rich Domain&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GAB1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C107455</classIRI>
<classLabel>GAB1 wt Allele</classLabel>
<deletedAxiom>&apos;GAB1 wt Allele&apos; SubClassOf &apos;GAB1 Gene&apos;</deletedAxiom>
<newAxiom>&apos;GAB1 wt Allele&apos; EquivalentTo &apos;GAB1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C89765</classIRI>
<classLabel>CDK7 wt Allele</classLabel>
<deletedAxiom>&apos;CDK7 wt Allele&apos; SubClassOf &apos;CDK7 Gene&apos;</deletedAxiom>
<newAxiom>&apos;CDK7 wt Allele&apos; EquivalentTo &apos;CDK7 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;EFP Cell Cycle Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ptc1 Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;RAR and RXR Degradation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Basal Transcription Factor Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Nucleotide Excision Repair Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Retinoic Acid Receptor Family-Mediated Signaling Pathway&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C89769</classIRI>
<classLabel>Cyclin-Dependent Kinase 7</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 7&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and &apos;Basal Transcription Factor&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;TFIIH&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Kinase Protein Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 7&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and &apos;Basal Transcription Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EFP Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ptc1 Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RAR and RXR Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Basal Transcription Factor Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nucleotide Excision Repair Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinoic Acid Receptor Family-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;TFIIH&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Kinase Protein Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C89974</classIRI>
<classLabel>CDISC SEND Microscopic Findings Test Code Terminology</classLabel>
<deletedAxiom>&apos;CDISC SEND Microscopic Findings Test Code Terminology&apos; SubClassOf &apos;CDISC SDTM Terminology&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C89973</classIRI>
<classLabel>CDISC SEND Microscopic Findings Test Name Terminology</classLabel>
<deletedAxiom>&apos;CDISC SEND Microscopic Findings Test Name Terminology&apos; SubClassOf &apos;CDISC SDTM Terminology&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132003</classIRI>
<classLabel>FANCF Gene Mutation</classLabel>
<newAxiom>&apos;FANCF Gene Mutation&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;FANCF Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132002</classIRI>
<classLabel>BRIP1 Gene Mutation</classLabel>
<newAxiom>&apos;BRIP1 Gene Mutation&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;BRIP1 Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132005</classIRI>
<classLabel>RAD51B Gene Mutation</classLabel>
<newAxiom>&apos;RAD51B Gene Mutation&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;RAD51B Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132004</classIRI>
<classLabel>FANCM Gene Mutation</classLabel>
<newAxiom>&apos;FANCM Gene Mutation&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;FANCM Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132007</classIRI>
<classLabel>RPA1 Gene Mutation</classLabel>
<newAxiom>&apos;RPA1 Gene Mutation&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;RPA1 Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132006</classIRI>
<classLabel>RAD54L Gene Mutation</classLabel>
<newAxiom>&apos;RAD54L Gene Mutation&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;RAD51B Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113593</classIRI>
<classLabel>OLFM4 wt Allele</classLabel>
<newAxiom>&apos;OLFM4 wt Allele&apos; SubClassOf &apos;Gene_In_Chromosomal_Location&apos; some &apos;13q14.3&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95297</classIRI>
<classLabel>CDK8 Gene</classLabel>
<deletedAxiom>&apos;CDK8 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Transcriptional Regulation&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17383</classIRI>
<classLabel>p21 K-Ras Protein</classLabel>
<deletedAxiom>&apos;p21 K-Ras Protein&apos; EquivalentTo &apos;p21 RAS Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KRAS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;p21 K-Ras Protein&apos; EquivalentTo &apos;p21 RAS Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Class I PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KRAS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17477</classIRI>
<classLabel>BCR Protein</classLabel>
<deletedAxiom>&apos;BCR Protein&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Acute Lymphoblastic Leukemia&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Chronic Myelogenous Leukemia, BCR-ABL1 Positive&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;BCR Protein&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and &apos;Serine/Threonine Protein Kinase&apos; and &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Acute Lymphoblastic Leukemia&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Chronic Myelogenous Leukemia, BCR-ABL1 Positive&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17416</classIRI>
<classLabel>RHOC Protein</classLabel>
<deletedAxiom>&apos;RHOC Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RHOC Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17415</classIRI>
<classLabel>Transforming Protein RHOA</classLabel>
<deletedAxiom>&apos;Transforming Protein RHOA&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Transforming Protein RHOA&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-1 Cell Spread Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora B Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Class I PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E-Cadherin Signaling Pathway in Keratinocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endothelin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lissencephaly-1 Gene in Neuronal Migration and Development&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTP4A Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Stabilization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17412</classIRI>
<classLabel>Neurofibromin</classLabel>
<deletedAxiom>&apos;Neurofibromin&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;hSWI-SNF Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Neurofibromatosis Type 1&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NF1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Neurofibromin&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;hSWI-SNF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA2 and FOXA3 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Neurofibromatosis Type 1&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Nuclear Localization Signal&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NF1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6002</classIRI>
<classLabel>Stage IVC Pharyngeal Cancer</classLabel>
<deletedAxiom>&apos;Stage IVC Pharyngeal Cancer&apos; EquivalentTo &apos;Stage IV Pharyngeal Cancer&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage IVC&apos;)</deletedAxiom>
<newAxiom>&apos;Stage IVC Pharyngeal Cancer&apos; SubClassOf &apos;Stage IV Pharyngeal Cancer&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6001</classIRI>
<classLabel>Stage IVB Pharyngeal Cancer</classLabel>
<deletedAxiom>&apos;Stage IVB Pharyngeal Cancer&apos; EquivalentTo &apos;Stage IV Pharyngeal Cancer&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage IVB&apos;)</deletedAxiom>
<newAxiom>&apos;Stage IVB Pharyngeal Cancer&apos; SubClassOf &apos;Stage IV Pharyngeal Cancer&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6000</classIRI>
<classLabel>Stage IVA Pharyngeal Cancer</classLabel>
<deletedAxiom>&apos;Stage IVA Pharyngeal Cancer&apos; EquivalentTo &apos;Stage IV Pharyngeal Cancer&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage IVA&apos;)</deletedAxiom>
<newAxiom>&apos;Stage IVA Pharyngeal Cancer&apos; SubClassOf &apos;Stage IV Pharyngeal Cancer&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17510</classIRI>
<classLabel>WNT2 Protein</classLabel>
<deletedAxiom>&apos;WNT2 Protein&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;WNT2 Protein&apos; EquivalentTo &apos;WNT Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WNT2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4050</classIRI>
<classLabel>Oligoastrocytoma</classLabel>
<deletedAxiom>&apos;Oligoastrocytoma&apos; EquivalentTo &apos;Low Grade Glioma&apos; and &apos;Mixed Glioma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Astrocyte&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Oligodendrocyte&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Oligodendroglial Component Present&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 2&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Seizure&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Headache&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Biphasic Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Microcystic Change&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Microcalcification&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Necrotic Change&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Microvascular Proliferation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;TP53 Gene Inactivation&apos;)</deletedAxiom>
<newAxiom>&apos;Oligoastrocytoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132505 and &apos;Mixed Glioma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Astrocyte&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Oligodendrocyte&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Oligodendroglial Component Present&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 2&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Seizure&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Headache&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Biphasic Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Microcystic Change&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Microcalcification&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Necrotic Change&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Microvascular Proliferation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;TP53 Gene Inactivation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17696</classIRI>
<classLabel>RAB8 Protein</classLabel>
<deletedAxiom>&apos;RAB8 Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAB8A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAB8 Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rab GTPases in Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAB8A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42720</classIRI>
<classLabel>Ras Protein Specific Guanine Nucleotide Releasing Factor 2</classLabel>
<deletedAxiom>&apos;Ras Protein Specific Guanine Nucleotide Releasing Factor 2&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Guanine Nucleotide Exchange Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RASGRF2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ras Protein Specific Guanine Nucleotide Releasing Factor 2&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RASGRF2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17793</classIRI>
<classLabel>Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha</classLabel>
<deletedAxiom>&apos;Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Pancreatic Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GADD45A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXO Transcription Factor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Pancreatic Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GADD45A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17812</classIRI>
<classLabel>TNF Receptor-Associated Factor 2</classLabel>
<deletedAxiom>&apos;TNF Receptor-Associated Factor 2&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;4-1BB-Dependent Immune Response Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Inhibitor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRAF2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;TNF Receptor-Associated Factor 2&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;4-1BB-Dependent Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40/CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TRAIL Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Inhibitor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRAF2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17976</classIRI>
<classLabel>Rho Guanine Nucleotide Exchange Factor 5</classLabel>
<deletedAxiom>&apos;Rho Guanine Nucleotide Exchange Factor 5&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rho Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ARHGEF5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Rho Guanine Nucleotide Exchange Factor 5&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132337 and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rho Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ARHGEF5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17982</classIRI>
<classLabel>Mothers Against Decapentaplegic Homolog 4</classLabel>
<deletedAxiom>&apos;Mothers Against Decapentaplegic Homolog 4&apos; EquivalentTo &apos;Transcription Factor&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Juvenile Polyposis Syndrome&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Malignant Colon Neoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Coactivator&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Sequence-Specific DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMAD4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mothers Against Decapentaplegic Homolog 4&apos; EquivalentTo &apos;Transcription Factor&apos; and &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Juvenile Polyposis Syndrome&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Malignant Colon Neoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Coactivator&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Sequence-Specific DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMAD4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4942</classIRI>
<classLabel>Stage 0 Pharyngeal Cancer</classLabel>
<deletedAxiom>&apos;Stage 0 Pharyngeal Cancer&apos; EquivalentTo &apos;Carcinoma In Situ&apos; and &apos;Pharyngeal Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage 0&apos;)</deletedAxiom>
<newAxiom>&apos;Stage 0 Pharyngeal Cancer&apos; SubClassOf &apos;Carcinoma In Situ&apos;</newAxiom>
<newAxiom>&apos;Stage 0 Pharyngeal Cancer&apos; SubClassOf &apos;Pharyngeal Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111690</classIRI>
<classLabel>Immunoglobulin Heavy Chain Locus Variable Region Mutation</classLabel>
<newAxiom>&apos;Immunoglobulin Heavy Chain Locus Variable Region Mutation&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;Immunoglobulin Heavy Locus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126306</classIRI>
<classLabel>Recurrent Glioblastoma</classLabel>
<deletedAxiom>&apos;Recurrent Glioblastoma&apos; EquivalentTo &apos;Recurrent Primary Malignant Neoplasm&apos; and &apos;Glioblastoma&apos; and &apos;Recurrent Central Nervous System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Glioblastoma&apos; EquivalentTo &apos;Recurrent Primary Malignant Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506 and &apos;Glioblastoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18034</classIRI>
<classLabel>Mothers Against Decapentaplegic Homolog 3</classLabel>
<deletedAxiom>&apos;Mothers Against Decapentaplegic Homolog 3&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Colorectal Adenocarcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Coactivator&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMAD3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mothers Against Decapentaplegic Homolog 3&apos; EquivalentTo &apos;Transcription Factor&apos; and &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Cytoplasmic and Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Colorectal Adenocarcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Coactivator&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMAD3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18056</classIRI>
<classLabel>Angiopoietin-2</classLabel>
<deletedAxiom>&apos;Angiopoietin-2&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Angiogenesis Inhibitory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ANGPT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Angiopoietin-2&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ANGPT2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18177</classIRI>
<classLabel>Axin-1</classLabel>
<deletedAxiom>&apos;Axin-1&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch and Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dorsal-Ventral Pattern Formation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AXIN1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Axin-1&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch and Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DIX Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;GSK-Binding Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dorsal-Ventral Pattern Formation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AXIN1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18284</classIRI>
<classLabel>ST5 Protein</classLabel>
<deletedAxiom>&apos;ST5 Protein&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ST5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;ST5 Protein&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ST5 Gene&apos;</newAxiom>
<newAxiom>&apos;ST5 Protein&apos; SubClassOf &apos;Guanine Nucleotide Exchange Factor&apos;</newAxiom>
<newAxiom>&apos;ST5 Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18283</classIRI>
<classLabel>VAV1 Protein</classLabel>
<deletedAxiom>&apos;VAV1 Protein&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;VAV1 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;VAV1 Protein&apos; SubClassOf &apos;Guanine Nucleotide Exchange Factor&apos;</deletedAxiom>
<newAxiom>&apos;VAV1 Protein&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Cell Activation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;VAV1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18365</classIRI>
<classLabel>VAV1 Gene</classLabel>
<deletedAxiom>&apos;VAV1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;B-Cell Activation&apos;</deletedAxiom>
<newAxiom>&apos;VAV1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Immune Cell Activation Process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18364</classIRI>
<classLabel>CBL Gene</classLabel>
<deletedAxiom>&apos;CBL Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;CBL Gene&apos; SubClassOf &apos;Ubiquitin Ligase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18455</classIRI>
<classLabel>BCR Gene</classLabel>
<newAxiom>&apos;BCR Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18547</classIRI>
<classLabel>CBL Protein</classLabel>
<deletedAxiom>&apos;CBL Protein&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CBL Gene&apos;)</deletedAxiom>
<newAxiom>&apos;CBL Protein&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CBL Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106613</classIRI>
<classLabel>Mothers Against Decapentaplegic Homolog 1</classLabel>
<deletedAxiom>&apos;Mothers Against Decapentaplegic Homolog 1&apos; EquivalentTo &apos;Transcription Factor&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Sequence-Specific DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMAD1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mothers Against Decapentaplegic Homolog 1&apos; EquivalentTo &apos;Transcription Factor&apos; and &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Sequence-Specific DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMAD1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131617</classIRI>
<classLabel>Recurrent Ependymal Tumor</classLabel>
<deletedAxiom>&apos;Recurrent Ependymal Tumor&apos; EquivalentTo &apos;Ependymal Tumor&apos; and &apos;Recurrent Central Nervous System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Ependymal Tumor&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506 and &apos;Ependymal Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131774</classIRI>
<classLabel>Deleterious BRIP1 Gene Mutation</classLabel>
<newAxiom>&apos;Deleterious BRIP1 Gene Mutation&apos; SubClassOf &apos;BRIP1 Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7939</classIRI>
<classLabel>Stage 0 Lip and Oral Cavity Cancer</classLabel>
<deletedAxiom>&apos;Stage 0 Lip and Oral Cavity Cancer&apos; EquivalentTo &apos;Carcinoma In Situ&apos; and &apos;Lip and Oral Cavity Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Stage 0 Lip and Oral Cavity Cancer&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132736 and &apos;Carcinoma In Situ&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38397</classIRI>
<classLabel>I-Kappa-B-Epsilon</classLabel>
<deletedAxiom>&apos;I-Kappa-B-Epsilon&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;I Kappa B&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NFKBIE Gene&apos;)</deletedAxiom>
<newAxiom>&apos;I-Kappa-B-Epsilon&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;I Kappa B&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NFKBIE Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38382</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein G(k) Subunit Alpha</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein G(k) Subunit Alpha&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNAI3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein G(k) Subunit Alpha&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNAI3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38380</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G(i) Alpha&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNAI1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G(i) Alpha&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNAI1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24252</classIRI>
<classLabel>BAG4 Gene</classLabel>
<deletedAxiom>&apos;BAG4 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;BAG4 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Protein Folding&apos;</newAxiom>
<newAxiom>&apos;BAG4 Gene&apos; SubClassOf &apos;Regulatory Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24261</classIRI>
<classLabel>BCL7A Gene</classLabel>
<deletedAxiom>&apos;BCL7A Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;BCL7A Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Transcriptional Regulation&apos;</newAxiom>
<newAxiom>&apos;BCL7A Gene&apos; SubClassOf &apos;Transcription Regulation Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97222</classIRI>
<classLabel>Kinase Suppressor of Ras 2</classLabel>
<deletedAxiom>&apos;Kinase Suppressor of Ras 2&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;</deletedAxiom>
<deletedAxiom>&apos;Kinase Suppressor of Ras 2&apos; SubClassOf &apos;Signaling Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;Kinase Suppressor of Ras 2&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KSR2 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;Kinase Suppressor of Ras 2&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Kinase Protein Phosphorylation&apos;</deletedAxiom>
<deletedAxiom>&apos;Kinase Suppressor of Ras 2&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Induction&apos;</deletedAxiom>
<deletedAxiom>&apos;Kinase Suppressor of Ras 2&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;</deletedAxiom>
<newAxiom>&apos;Kinase Suppressor of Ras 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Renal Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Scaffolding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KSR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97220</classIRI>
<classLabel>KSR2 Gene</classLabel>
<deletedAxiom>&apos;KSR2 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;KSR2 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Protein Kinase Protein Phosphorylation&apos;</deletedAxiom>
<newAxiom>&apos;KSR2 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
<newAxiom>&apos;KSR2 Gene&apos; SubClassOf &apos;Serine/Threonine Protein Kinase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97267</classIRI>
<classLabel>Rho-Guanine Nucleotide Exchange Factor</classLabel>
<deletedAxiom>&apos;Rho-Guanine Nucleotide Exchange Factor&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGNEF Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Rho-Guanine Nucleotide Exchange Factor&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGNEF Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24331</classIRI>
<classLabel>DBC1 Gene</classLabel>
<deletedAxiom>&apos;DBC1 Gene&apos; SubClassOf &apos;Receptor Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;DBC1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Receptor Signaling&apos;</deletedAxiom>
<newAxiom>&apos;DBC1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;</newAxiom>
<newAxiom>&apos;DBC1 Gene&apos; SubClassOf &apos;Cell Cycle Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24349</classIRI>
<classLabel>DOK1 Gene</classLabel>
<deletedAxiom>&apos;DOK1 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;DOK1 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24358</classIRI>
<classLabel>EDN2 Gene</classLabel>
<newAxiom>&apos;EDN2 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Muscle Contraction&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24370</classIRI>
<classLabel>EPS8 Gene</classLabel>
<deletedAxiom>&apos;EPS8 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;EPS8 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24303</classIRI>
<classLabel>CNKSR1 Gene</classLabel>
<deletedAxiom>&apos;CNKSR1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Gene Regulation Process&apos;</deletedAxiom>
<deletedAxiom>&apos;CNKSR1 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;CNKSR1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Receptor Signaling&apos;</newAxiom>
<newAxiom>&apos;CNKSR1 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24431</classIRI>
<classLabel>GIT2 Gene</classLabel>
<newAxiom>&apos;GIT2 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97441</classIRI>
<classLabel>Signal Transduction Protein CBL-C</classLabel>
<deletedAxiom>&apos;Signal Transduction Protein CBL-C&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CBLC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Signal Transduction Protein CBL-C&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CBLC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97439</classIRI>
<classLabel>CBLC Gene</classLabel>
<deletedAxiom>&apos;CBLC Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;CBLC Gene&apos; SubClassOf &apos;Ubiquitin Ligase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24568</classIRI>
<classLabel>SMAD7 Gene</classLabel>
<newAxiom>&apos;SMAD7 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Transcriptional Regulation&apos;</newAxiom>
<newAxiom>&apos;SMAD7 Gene&apos; SubClassOf &apos;Transcription Coregulator Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24594</classIRI>
<classLabel>MFNG Gene</classLabel>
<deletedAxiom>&apos;MFNG Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;MFNG Gene&apos; SubClassOf &apos;Glycosyltransferase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24505</classIRI>
<classLabel>IL6ST Gene</classLabel>
<deletedAxiom>&apos;IL6ST Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;IL6ST Gene&apos; SubClassOf &apos;Cytokine Receptor Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24518</classIRI>
<classLabel>IRAK1 Gene</classLabel>
<newAxiom>&apos;IRAK1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Immune Response Process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24510</classIRI>
<classLabel>ILK Gene</classLabel>
<deletedAxiom>&apos;ILK Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;ILK Gene&apos; SubClassOf &apos;Serine/Threonine Protein Kinase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24537</classIRI>
<classLabel>KSR1 Gene</classLabel>
<deletedAxiom>&apos;KSR1 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;KSR1 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24725</classIRI>
<classLabel>RARRES3 Gene</classLabel>
<deletedAxiom>&apos;RARRES3 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;</deletedAxiom>
<deletedAxiom>&apos;RARRES3 Gene&apos; SubClassOf &apos;Regulatory Gene&apos;</deletedAxiom>
<newAxiom>&apos;RARRES3 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;</newAxiom>
<newAxiom>&apos;RARRES3 Gene&apos; SubClassOf &apos;Esterase Gene&apos;</newAxiom>
<newAxiom>&apos;RARRES3 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Phospholipid Metabolism&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24756</classIRI>
<classLabel>RASL10A Gene</classLabel>
<newAxiom>&apos;RASL10A Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24882</classIRI>
<classLabel>TSKS Gene</classLabel>
<deletedAxiom>&apos;TSKS Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;TSKS Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Spermatogenesis&apos;</newAxiom>
<newAxiom>&apos;TSKS Gene&apos; SubClassOf &apos;Regulatory Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101415</classIRI>
<classLabel>Activation-Induced Cytidine Deaminase</classLabel>
<deletedAxiom>&apos;Activation-Induced Cytidine Deaminase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymph Node Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Tonsillar Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Differentiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AICDA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Activation-Induced Cytidine Deaminase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymph Node Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Tonsillar Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Differentiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AICDA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101414</classIRI>
<classLabel>AICDA wt Allele</classLabel>
<deletedAxiom>&apos;AICDA wt Allele&apos; EquivalentTo &apos;AICDA Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12p13&apos;)</deletedAxiom>
<newAxiom>&apos;AICDA wt Allele&apos; EquivalentTo &apos;AICDA Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12p13&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101454</classIRI>
<classLabel>Epithelial Cell-Transforming Sequence 2 Oncogene-Like</classLabel>
<deletedAxiom>&apos;Epithelial Cell-Transforming Sequence 2 Oncogene-Like&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8087</classIRI>
<classLabel>Recurrent Ovarian Germ Cell Tumor</classLabel>
<deletedAxiom>&apos;Recurrent Ovarian Germ Cell Tumor&apos; EquivalentTo &apos;Recurrent Primary Malignant Neoplasm&apos; and &apos;Malignant Ovarian Germ Cell Tumor&apos; and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;i(12p)&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 12p&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Abdominal Pain&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Abdominal Mass&apos;)</deletedAxiom>
<newAxiom>&apos;Recurrent Ovarian Germ Cell Tumor&apos; EquivalentTo &apos;Recurrent Primary Malignant Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132853 and &apos;Malignant Ovarian Germ Cell Tumor&apos; and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;i(12p)&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 12p&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Abdominal Pain&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Abdominal Mass&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8035</classIRI>
<classLabel>Stage III Lip and Oral Cavity Cancer</classLabel>
<deletedAxiom>&apos;Stage III Lip and Oral Cavity Cancer&apos; EquivalentTo &apos;Lip and Oral Cavity Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage III&apos;)</deletedAxiom>
<newAxiom>&apos;Stage III Lip and Oral Cavity Cancer&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132736 and (&apos;Disease_Is_Stage&apos; some &apos;Stage III&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8036</classIRI>
<classLabel>Stage IV Lip and Oral Cavity Cancer</classLabel>
<deletedAxiom>&apos;Stage IV Lip and Oral Cavity Cancer&apos; EquivalentTo &apos;Lip and Oral Cavity Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage IV&apos;)</deletedAxiom>
<newAxiom>&apos;Stage IV Lip and Oral Cavity Cancer&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132736 and (&apos;Disease_Is_Stage&apos; some &apos;Stage IV&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8033</classIRI>
<classLabel>Stage I Lip and Oral Cavity Cancer</classLabel>
<deletedAxiom>&apos;Stage I Lip and Oral Cavity Cancer&apos; EquivalentTo &apos;Lip and Oral Cavity Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage I&apos;)</deletedAxiom>
<newAxiom>&apos;Stage I Lip and Oral Cavity Cancer&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132736 and (&apos;Disease_Is_Stage&apos; some &apos;Stage I&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8034</classIRI>
<classLabel>Stage II Lip and Oral Cavity Cancer</classLabel>
<deletedAxiom>&apos;Stage II Lip and Oral Cavity Cancer&apos; EquivalentTo &apos;Lip and Oral Cavity Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage II&apos;)</deletedAxiom>
<newAxiom>&apos;Stage II Lip and Oral Cavity Cancer&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132736 and (&apos;Disease_Is_Stage&apos; some &apos;Stage II&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115385</classIRI>
<classLabel>Recurrent Malignant Extragonadal Germ Cell Tumor</classLabel>
<deletedAxiom>&apos;Recurrent Malignant Extragonadal Germ Cell Tumor&apos; EquivalentTo &apos;Recurrent Primary Malignant Neoplasm&apos; and &apos;Malignant Extragonadal Germ Cell Tumor&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Malignant Extragonadal Germ Cell Tumor&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132853 and &apos;Malignant Extragonadal Germ Cell Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115359</classIRI>
<classLabel>Recurrent Childhood Anaplastic Oligodendroglioma</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Anaplastic Oligodendroglioma&apos; EquivalentTo &apos;Recurrent Primary Malignant Neoplasm&apos; and &apos;Childhood Anaplastic Oligodendroglioma&apos; and &apos;Recurrent Childhood Central Nervous System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Anaplastic Oligodendroglioma&apos; EquivalentTo &apos;Recurrent Primary Malignant Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506 and &apos;Childhood Anaplastic Oligodendroglioma&apos; and &apos;Recurrent Childhood Central Nervous System Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115358</classIRI>
<classLabel>Recurrent Childhood Anaplastic Oligoastrocytoma</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Anaplastic Oligoastrocytoma&apos; EquivalentTo &apos;Childhood Anaplastic Oligoastrocytoma&apos; and &apos;Recurrent Primary Malignant Neoplasm&apos; and &apos;Recurrent Childhood Central Nervous System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Anaplastic Oligoastrocytoma&apos; EquivalentTo &apos;Childhood Anaplastic Oligoastrocytoma&apos; and &apos;Recurrent Primary Malignant Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506 and &apos;Recurrent Childhood Central Nervous System Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115366</classIRI>
<classLabel>Recurrent Childhood Gliomatosis Cerebri</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Gliomatosis Cerebri&apos; EquivalentTo &apos;Childhood Gliomatosis Cerebri&apos; and &apos;Recurrent Childhood Brain Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Gliomatosis Cerebri&apos; EquivalentTo &apos;Childhood Gliomatosis Cerebri&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506 and &apos;Recurrent Childhood Brain Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115371</classIRI>
<classLabel>Recurrent Childhood Oligodendroglioma</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Oligodendroglioma&apos; EquivalentTo &apos;Childhood Oligodendroglioma&apos; and &apos;Recurrent Childhood Central Nervous System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Oligodendroglioma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506 and &apos;Childhood Oligodendroglioma&apos; and &apos;Recurrent Childhood Central Nervous System Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115370</classIRI>
<classLabel>Recurrent Childhood Oligoastrocytoma</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Oligoastrocytoma&apos; EquivalentTo &apos;Childhood Oligoastrocytoma&apos; and &apos;Recurrent Childhood Central Nervous System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Oligoastrocytoma&apos; EquivalentTo &apos;Childhood Oligoastrocytoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506 and &apos;Recurrent Childhood Central Nervous System Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30001</classIRI>
<classLabel>Link Guanine Nucleotide Exchange Factor II</classLabel>
<deletedAxiom>&apos;Link Guanine Nucleotide Exchange Factor II&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Guanine Nucleotide Exchange Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAPGEFL1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Link Guanine Nucleotide Exchange Factor II&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
<newAxiom>&apos;Link Guanine Nucleotide Exchange Factor II&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAPGEFL1 Gene&apos;</newAxiom>
<newAxiom>&apos;Link Guanine Nucleotide Exchange Factor II&apos; SubClassOf &apos;Guanine Nucleotide Exchange Factor&apos;</newAxiom>
<newAxiom>&apos;Link Guanine Nucleotide Exchange Factor II&apos; SubClassOf &apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30077</classIRI>
<classLabel>TANK-Binding Kinase 1</classLabel>
<deletedAxiom>&apos;TANK-Binding Kinase 1&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TBK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;TANK-Binding Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytosolic DNA-Sensing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TBK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30118</classIRI>
<classLabel>Phosphoprotein Associated with GEMs</classLabel>
<deletedAxiom>&apos;Phosphoprotein Associated with GEMs&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAG1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Phosphoprotein Associated with GEMs&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAG1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30115</classIRI>
<classLabel>Toll-Interacting Protein</classLabel>
<deletedAxiom>&apos;Toll-Interacting Protein&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOLLIP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Toll-Interacting Protein&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOLLIP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30114</classIRI>
<classLabel>Non-Receptor Tyrosine Kinase 1</classLabel>
<deletedAxiom>&apos;Non-Receptor Tyrosine Kinase 1&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Non-Receptor Tyrosine Kinase 1&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Proline-Rich Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30128</classIRI>
<classLabel>T-Cell Receptor Interacting Molecule</classLabel>
<deletedAxiom>&apos;T-Cell Receptor Interacting Molecule&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRAT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;T-Cell Receptor Interacting Molecule&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRAT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30129</classIRI>
<classLabel>Triple Functional Domain Protein</classLabel>
<deletedAxiom>&apos;Triple Functional Domain Protein&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIO Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Triple Functional Domain Protein&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Substrate Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIO Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30134</classIRI>
<classLabel>Testis-Specific Kinase Substrate</classLabel>
<deletedAxiom>&apos;Testis-Specific Kinase Substrate&apos; SubClassOf &apos;Signaling Protein&apos;</deletedAxiom>
<newAxiom>&apos;Testis-Specific Kinase Substrate&apos; SubClassOf &apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testicular Tissue&apos;</newAxiom>
<newAxiom>&apos;Testis-Specific Kinase Substrate&apos; SubClassOf &apos;Regulatory Protein&apos;</newAxiom>
<newAxiom>&apos;Testis-Specific Kinase Substrate&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
<newAxiom>&apos;Testis-Specific Kinase Substrate&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centriole&apos;</newAxiom>
<newAxiom>&apos;Testis-Specific Kinase Substrate&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Spermatogenesis&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30130</classIRI>
<classLabel>Thyroid Hormone Receptor Interactor 10</classLabel>
<deletedAxiom>&apos;Thyroid Hormone Receptor Interactor 10&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIP10 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Thyroid Hormone Receptor Interactor 10&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin-Mediated Glucose Transport Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIP10 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78145</classIRI>
<classLabel>CD86 Gene</classLabel>
<deletedAxiom>&apos;CD86 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;CD86 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Immune Response Process&apos;</newAxiom>
<newAxiom>&apos;CD86 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Intercellular Communication Process&apos;</newAxiom>
<newAxiom>&apos;CD86 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Receptor Signaling&apos;</newAxiom>
<newAxiom>&apos;CD86 Gene&apos; SubClassOf &apos;Receptor Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78146</classIRI>
<classLabel>CD86 wt Allele</classLabel>
<deletedAxiom>&apos;CD86 wt Allele&apos; SubClassOf &apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;</deletedAxiom>
<deletedAxiom>&apos;CD86 wt Allele&apos; SubClassOf &apos;Gene_In_Chromosomal_Location&apos; some &apos;3q21&apos;</deletedAxiom>
<deletedAxiom>&apos;CD86 wt Allele&apos; SubClassOf &apos;CD86 Gene&apos;</deletedAxiom>
<newAxiom>&apos;CD86 wt Allele&apos; EquivalentTo &apos;CD86 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Co-Stimulatory Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Th1/Th2 Differentiation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Allograft Rejection Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cell Adhesion Molecule Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Graft-Versus-Host Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Systemic Lupus Erythematosus Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Autoimmune Thyroid Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Type I Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL12/STAT4 Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;3q21&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78147</classIRI>
<classLabel>T-Lymphocyte Activation Antigen CD86</classLabel>
<deletedAxiom>&apos;T-Lymphocyte Activation Antigen CD86&apos; SubClassOf &apos;Signaling Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;T-Lymphocyte Activation Antigen CD86&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CD86 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;T-Lymphocyte Activation Antigen CD86&apos; SubClassOf &apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;</deletedAxiom>
<deletedAxiom>&apos;T-Lymphocyte Activation Antigen CD86&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Proliferation&apos;</deletedAxiom>
<newAxiom>&apos;T-Lymphocyte Activation Antigen CD86&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Co-Stimulatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th1/Th2 Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Allograft Rejection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Adhesion Molecule Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Graft-Versus-Host Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Systemic Lupus Erythematosus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Autoimmune Thyroid Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type I Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12/STAT4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Cluster of Differentiation&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Monocyte&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Activated B-Lymphocyte&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like V-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CD86 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129685</classIRI>
<classLabel>KEAP1 Gene Mutation</classLabel>
<newAxiom>&apos;KEAP1 Gene Mutation&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;KEAP1 Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8769</classIRI>
<classLabel>Stage II Pharyngeal Cancer</classLabel>
<deletedAxiom>&apos;Stage II Pharyngeal Cancer&apos; EquivalentTo &apos;Pharyngeal Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage II&apos;)</deletedAxiom>
<newAxiom>&apos;Stage II Pharyngeal Cancer&apos; SubClassOf &apos;Pharyngeal Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8768</classIRI>
<classLabel>Stage I Pharyngeal Cancer</classLabel>
<deletedAxiom>&apos;Stage I Pharyngeal Cancer&apos; EquivalentTo &apos;Pharyngeal Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage I&apos;)</deletedAxiom>
<newAxiom>&apos;Stage I Pharyngeal Cancer&apos; SubClassOf &apos;Pharyngeal Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8770</classIRI>
<classLabel>Stage III Pharyngeal Cancer</classLabel>
<deletedAxiom>&apos;Stage III Pharyngeal Cancer&apos; EquivalentTo &apos;Pharyngeal Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage III&apos;)</deletedAxiom>
<newAxiom>&apos;Stage III Pharyngeal Cancer&apos; SubClassOf &apos;Pharyngeal Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8771</classIRI>
<classLabel>Stage IV Pharyngeal Cancer</classLabel>
<deletedAxiom>&apos;Stage IV Pharyngeal Cancer&apos; EquivalentTo &apos;Pharyngeal Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;Stage IV&apos;)</deletedAxiom>
<newAxiom>&apos;Stage IV Pharyngeal Cancer&apos; SubClassOf &apos;Pharyngeal Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25863</classIRI>
<classLabel>ADAM Type Metalloprotease Domain</classLabel>
<deletedAxiom>&apos;ADAM Type Metalloprotease Domain&apos; SubClassOf &apos;Protein Domain&apos;</deletedAxiom>
<newAxiom>&apos;ADAM Type Metalloprotease Domain&apos; SubClassOf &apos;Protease Domain&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114956</classIRI>
<classLabel>Recurrent Childhood Astrocytic Tumor</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Astrocytic Tumor&apos; EquivalentTo &apos;Childhood Astrocytic Tumor&apos; and &apos;Recurrent Childhood Central Nervous System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Astrocytic Tumor&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506 and &apos;Childhood Astrocytic Tumor&apos; and &apos;Recurrent Childhood Central Nervous System Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25990</classIRI>
<classLabel>Connector Enhancer of KSR-Like Protein</classLabel>
<deletedAxiom>&apos;Connector Enhancer of KSR-Like Protein&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CNKSR1 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;Connector Enhancer of KSR-Like Protein&apos; SubClassOf &apos;Adaptor Signaling Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;Connector Enhancer of KSR-Like Protein&apos; SubClassOf &apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;</deletedAxiom>
<newAxiom>&apos;Connector Enhancer of KSR-Like Protein&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cell Junction&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SAM Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Proline-Rich Domain&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CNKSR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25997</classIRI>
<classLabel>Adaptor Signaling Protein Gene</classLabel>
<newAxiom>&apos;Adaptor Signaling Protein Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Receptor Signaling&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128901</classIRI>
<classLabel>Activating RAS Mutation</classLabel>
<deletedAxiom>&apos;Activating RAS Mutation&apos; SubClassOf &apos;Gene Abnormality&apos;</deletedAxiom>
<newAxiom>&apos;Activating RAS Mutation&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132229</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70616</classIRI>
<classLabel>HLA Class II Histocompatibility Antigen DQ(1) Beta Chain</classLabel>
<deletedAxiom>&apos;HLA Class II Histocompatibility Antigen DQ(1) Beta Chain&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HLA-DQB1 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;HLA Class II Histocompatibility Antigen DQ(1) Beta Chain&apos; SubClassOf &apos;HLA-DQ Antigen&apos;</deletedAxiom>
<newAxiom>&apos;HLA Class II Histocompatibility Antigen DQ(1) Beta Chain&apos; EquivalentTo &apos;HLA-DQ Antigen&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Antigen Dependent B Cell Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bystander B Cell Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Co-Stimulatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Allergy Chemokine Network Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inflammatory Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Antigen Presentation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TCR Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th1/Th2 Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Lymphocyte Cell Surface Molecule Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Antigen Processing and Presentation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Allograft Rejection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Adhesion Molecule Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Graft-Versus-Host Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Asthma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Systemic Lupus Erythematosus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Autoimmune Thyroid Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type I Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12/STAT4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antigen Presentation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Receptor Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HLA-DQB1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70614</classIRI>
<classLabel>HLA-DQB1 Gene</classLabel>
<newAxiom>&apos;HLA-DQB1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;T-Cell Receptor Activation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70615</classIRI>
<classLabel>HLA-DQB1 wt Allele</classLabel>
<deletedAxiom>&apos;HLA-DQB1 wt Allele&apos; SubClassOf &apos;Gene_In_Chromosomal_Location&apos; some &apos;6p21.3&apos;</deletedAxiom>
<deletedAxiom>&apos;HLA-DQB1 wt Allele&apos; SubClassOf &apos;HLA-DQB1 Gene&apos;</deletedAxiom>
<newAxiom>&apos;HLA-DQB1 wt Allele&apos; EquivalentTo &apos;HLA-DQB1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Antigen Dependent B Cell Activation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bystander B Cell Activation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Co-Stimulatory Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Allergy Chemokine Network Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL5 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Inflammatory Response Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Antigen Presentation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TCR Activation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Th1/Th2 Differentiation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;B Lymphocyte Cell Surface Molecule Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Antigen Processing and Presentation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Allograft Rejection Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cell Adhesion Molecule Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Graft-Versus-Host Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Asthma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Systemic Lupus Erythematosus Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Autoimmune Thyroid Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Type I Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL12/STAT4 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Phagocytosis Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;6p21.3&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7173</classIRI>
<classLabel>Diffuse Astrocytoma</classLabel>
<deletedAxiom>&apos;Diffuse Astrocytoma&apos; EquivalentTo &apos;Low Grade Astrocytic Tumor&apos; and &apos;Diffuse Glioma&apos; and &apos;Astrocytoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Infiltrative Growth Pattern&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 2&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 7q&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Seizure&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Headache&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Calcification&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Motor Manifestations&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Sensory Manifestations&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Mitotic Activity&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Necrotic Change&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Microvascular Proliferation&apos;)</deletedAxiom>
<newAxiom>&apos;Diffuse Astrocytoma&apos; EquivalentTo &apos;Diffuse Glioma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132505 and &apos;Astrocytoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Infiltrative Growth Pattern&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 2&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 7q&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Seizure&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Headache&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Calcification&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Motor Manifestations&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Sensory Manifestations&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Mitotic Activity&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Necrotic Change&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Microvascular Proliferation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7529</classIRI>
<classLabel>Recurrent Childhood Visual Pathway Glioma</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Visual Pathway Glioma&apos; EquivalentTo &apos;Childhood Visual Pathway Glioma&apos; and &apos;Recurrent Childhood Brain Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Visual Pathway Glioma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506 and &apos;Childhood Visual Pathway Glioma&apos; and &apos;Recurrent Childhood Brain Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90525</classIRI>
<classLabel>Pharyngeal Carcinoma by AJCC v6 Stage</classLabel>
<deletedAxiom>&apos;Pharyngeal Carcinoma by AJCC v6 Stage&apos; SubClassOf &apos;Pharyngeal Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Pharyngeal Carcinoma by AJCC v6 Stage&apos; EquivalentTo &apos;Pharyngeal Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;AJCC v6 Stage&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90524</classIRI>
<classLabel>Hypopharyngeal Carcinoma by AJCC v6 Stage</classLabel>
<deletedAxiom>&apos;Hypopharyngeal Carcinoma by AJCC v6 Stage&apos; SubClassOf &apos;Hypopharyngeal Carcinoma&apos;</deletedAxiom>
<deletedAxiom>&apos;Hypopharyngeal Carcinoma by AJCC v6 Stage&apos; SubClassOf &apos;Pharyngeal Carcinoma by AJCC v6 Stage&apos;</deletedAxiom>
<newAxiom>&apos;Hypopharyngeal Carcinoma by AJCC v6 Stage&apos; EquivalentTo &apos;Pharyngeal Carcinoma by AJCC v6 Stage&apos; and &apos;Hypopharyngeal Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90523</classIRI>
<classLabel>Oropharyngeal Carcinoma by AJCC v6 Stage</classLabel>
<deletedAxiom>&apos;Oropharyngeal Carcinoma by AJCC v6 Stage&apos; SubClassOf &apos;Pharyngeal Carcinoma by AJCC v6 Stage&apos;</deletedAxiom>
<deletedAxiom>&apos;Oropharyngeal Carcinoma by AJCC v6 Stage&apos; SubClassOf &apos;Oropharyngeal Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Oropharyngeal Carcinoma by AJCC v6 Stage&apos; EquivalentTo &apos;Pharyngeal Carcinoma by AJCC v6 Stage&apos; and &apos;Oropharyngeal Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90522</classIRI>
<classLabel>Nasopharyngeal Carcinoma by AJCC v6 Stage</classLabel>
<deletedAxiom>&apos;Nasopharyngeal Carcinoma by AJCC v6 Stage&apos; SubClassOf &apos;Pharyngeal Carcinoma by AJCC v6 Stage&apos;</deletedAxiom>
<deletedAxiom>&apos;Nasopharyngeal Carcinoma by AJCC v6 Stage&apos; SubClassOf &apos;Nasopharyngeal Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Nasopharyngeal Carcinoma by AJCC v6 Stage&apos; EquivalentTo &apos;Nasopharyngeal Carcinoma&apos; and &apos;Pharyngeal Carcinoma by AJCC v6 Stage&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26178</classIRI>
<classLabel>Epidermal Growth Factor Receptor Pathway Substrate 8</classLabel>
<deletedAxiom>&apos;Epidermal Growth Factor Receptor Pathway Substrate 8&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EPS8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Epidermal Growth Factor Receptor Pathway Substrate 8&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Amphipathic Alpha Helix&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Proline-Rich Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EPS8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26190</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein G(i) Alpha-2 Subunit</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein G(i) Alpha-2 Subunit&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G(i) Alpha&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNAI2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein G(i) Alpha-2 Subunit&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G(i) Alpha&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNAI2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26184</classIRI>
<classLabel>ARF GTPase-Activating Protein GIT1</classLabel>
<deletedAxiom>&apos;ARF GTPase-Activating Protein GIT1&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GIT1 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;ARF GTPase-Activating Protein GIT1&apos; SubClassOf &apos;GTPase-Activating Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;ARF GTPase-Activating Protein GIT1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</deletedAxiom>
<newAxiom>&apos;ARF GTPase-Activating Protein GIT1&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Stabilization Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GIT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26186</classIRI>
<classLabel>G Protein-Coupled Receptor Kinase-Interactor 2</classLabel>
<deletedAxiom>&apos;G Protein-Coupled Receptor Kinase-Interactor 2&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GIT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G Protein-Coupled Receptor Kinase-Interactor 2&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GIT2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26189</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein Subunit Alpha-12</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein Subunit Alpha-12&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNA12 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein Subunit Alpha-12&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 5 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNA12 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26194</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-2</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-2&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNB2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-2&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNB2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26192</classIRI>
<classLabel>GRB2-Associated-Binding Protein 2</classLabel>
<deletedAxiom>&apos;GRB2-Associated-Binding Protein 2&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GAB2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;GRB2-Associated-Binding Protein 2&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3-Binding Motif&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GAB2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C51173</classIRI>
<classLabel>PRKG2 wt Allele</classLabel>
<deletedAxiom>&apos;PRKG2 wt Allele&apos; EquivalentTo &apos;PRKG2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ion Channels in Vascular Endothelium Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;4q13.1-q21.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;PRKG2 wt Allele&apos; EquivalentTo &apos;PRKG2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ion Channels in Vascular Endothelium Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;4q13.1-q21.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C51193</classIRI>
<classLabel>BCR wt Allele</classLabel>
<deletedAxiom>&apos;BCR wt Allele&apos; EquivalentTo &apos;BCR Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;22: 21847106-21982698&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;22q11.23&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;BCR wt Allele&apos; EquivalentTo &apos;BCR Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;22: 21847106-21982698&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;22q11.23&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26117</classIRI>
<classLabel>Docking Protein 1</classLabel>
<deletedAxiom>&apos;Docking Protein 1&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Leukocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Docking&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DOK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Docking Protein 1&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Leukocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Proline-Rich Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Scaffolding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Docking&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DOK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26141</classIRI>
<classLabel>BCL2-associated Athanogene 4</classLabel>
<deletedAxiom>&apos;BCL2-associated Athanogene 4&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BAG4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;BCL2-associated Athanogene 4&apos; EquivalentTo &apos;Apoptosis Regulator&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Inhibitor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BAG4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26151</classIRI>
<classLabel>Endothelin-2</classLabel>
<deletedAxiom>&apos;Endothelin-2&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Endothelium&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EDN2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Endothelin-2&apos; EquivalentTo &apos;Peptide Hormone&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endothelin Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Endothelium&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Muscle Contraction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EDN2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C122730</classIRI>
<classLabel>Central Memory Immune Cell</classLabel>
<deletedAxiom>&apos;Central Memory Immune Cell&apos; SubClassOf &apos;Hematopoietic and Lymphoid Cell&apos;</deletedAxiom>
<newAxiom>&apos;Central Memory Immune Cell&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132890</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26224</classIRI>
<classLabel>Growth Factor Receptor-Bound Protein 7</classLabel>
<deletedAxiom>&apos;Growth Factor Receptor-Bound Protein 7&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRB7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Growth Factor Receptor-Bound Protein 7&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRB7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26231</classIRI>
<classLabel>Adaptor Signaling Protein</classLabel>
<newAxiom>&apos;Adaptor Signaling Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26230</classIRI>
<classLabel>Growth Factor Receptor-Bound Protein 14</classLabel>
<deletedAxiom>&apos;Growth Factor Receptor-Bound Protein 14&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRB14 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Growth Factor Receptor-Bound Protein 14&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRB14 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26249</classIRI>
<classLabel>Regulator of G-Protein Signaling 1</classLabel>
<deletedAxiom>&apos;Regulator of G-Protein Signaling 1&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 1&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26250</classIRI>
<classLabel>Regulator of G-Protein Signaling 2</classLabel>
<deletedAxiom>&apos;Regulator of G-Protein Signaling 2&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</deletedAxiom>
<deletedAxiom>&apos;Regulator of G-Protein Signaling 2&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS2 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;Regulator of G-Protein Signaling 2&apos; SubClassOf &apos;RGS Family Protein&apos;</deletedAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 2&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26265</classIRI>
<classLabel>Interleukin 6 Signal Transducer</classLabel>
<deletedAxiom>&apos;Interleukin 6 Signal Transducer&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL6ST Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interleukin 6 Signal Transducer&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL27-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL6ST Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26290</classIRI>
<classLabel>Integrin-Linked Kinase</classLabel>
<deletedAxiom>&apos;Integrin-Linked Kinase&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ILK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Integrin-Linked Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ILK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26302</classIRI>
<classLabel>IRAK4 Gene</classLabel>
<deletedAxiom>&apos;IRAK4 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Protein Phosphorylation Process&apos;</deletedAxiom>
<deletedAxiom>&apos;IRAK4 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;IRAK4 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Immune Response Process&apos;</newAxiom>
<newAxiom>&apos;IRAK4 Gene&apos; SubClassOf &apos;Serine/Threonine Protein Kinase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26335</classIRI>
<classLabel>Kinase Suppressor of RAS-1</classLabel>
<deletedAxiom>&apos;Kinase Suppressor of RAS-1&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KSR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Kinase Suppressor of RAS-1&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Scaffolding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KSR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C51328</classIRI>
<classLabel>TBK1 wt Allele</classLabel>
<deletedAxiom>&apos;TBK1 wt Allele&apos; EquivalentTo &apos;TBK1 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q14.1&apos;)</deletedAxiom>
<newAxiom>&apos;TBK1 wt Allele&apos; EquivalentTo &apos;TBK1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cytosolic DNA-Sensing Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q14.1&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26483</classIRI>
<classLabel>SARA Protein</classLabel>
<deletedAxiom>&apos;SARA Protein&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Alzheimer&apos;s Disease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ZFYVE9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SARA Protein&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Alzheimer&apos;s Disease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ZFYVE9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26482</classIRI>
<classLabel>SMAD7 Protein</classLabel>
<deletedAxiom>&apos;SMAD7 Protein&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMAD7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SMAD7 Protein&apos; EquivalentTo &apos;Transcription Regulatory Protein&apos; and &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMAD7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C288</classIRI>
<classLabel>Azacitidine</classLabel>
<newAxiom>&apos;Azacitidine&apos; SubClassOf &apos;DNA Methyltransferase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71266</classIRI>
<classLabel>HLA-DQA1 wt Allele</classLabel>
<deletedAxiom>&apos;HLA-DQA1 wt Allele&apos; EquivalentTo &apos;HLA-DQA1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Antigen Processing and Presentation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Allograft Rejection Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cell Adhesion Molecule Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Graft-Versus-Host Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Asthma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Systemic Lupus Erythematosus Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Autoimmune Thyroid Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Type I Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Phagocytosis Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;6p21.3&apos;)</deletedAxiom>
<newAxiom>&apos;HLA-DQA1 wt Allele&apos; EquivalentTo &apos;HLA-DQA1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Antigen Processing and Presentation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Allograft Rejection Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cell Adhesion Molecule Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Graft-Versus-Host Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Asthma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Systemic Lupus Erythematosus Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Autoimmune Thyroid Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Type I Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Phagocytosis Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;6p21.3&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103945</classIRI>
<classLabel>Gamma-Glutamyl Hydrolase</classLabel>
<deletedAxiom>&apos;Gamma-Glutamyl Hydrolase&apos; EquivalentTo &apos;Peptidase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Folate Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Folic Acid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GGH Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Gamma-Glutamyl Hydrolase&apos; EquivalentTo &apos;Cysteine Proteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Folate Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Folic Acid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GGH Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103943</classIRI>
<classLabel>GGH Gene</classLabel>
<deletedAxiom>&apos;GGH Gene&apos; SubClassOf &apos;Peptidase Gene&apos;</deletedAxiom>
<newAxiom>&apos;GGH Gene&apos; SubClassOf &apos;Cysteine Peptidase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91252</classIRI>
<classLabel>Pharyngeal Carcinoma by AJCC v7 Stage</classLabel>
<deletedAxiom>&apos;Pharyngeal Carcinoma by AJCC v7 Stage&apos; SubClassOf &apos;Pharyngeal Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Pharyngeal Carcinoma by AJCC v7 Stage&apos; EquivalentTo &apos;Pharyngeal Carcinoma&apos; and (&apos;Disease_Is_Stage&apos; some &apos;AJCC v7 Stage&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91251</classIRI>
<classLabel>Hypopharyngeal Carcinoma by AJCC v7 Stage</classLabel>
<deletedAxiom>&apos;Hypopharyngeal Carcinoma by AJCC v7 Stage&apos; SubClassOf &apos;Pharyngeal Carcinoma by AJCC v7 Stage&apos;</deletedAxiom>
<deletedAxiom>&apos;Hypopharyngeal Carcinoma by AJCC v7 Stage&apos; SubClassOf &apos;Hypopharyngeal Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Hypopharyngeal Carcinoma by AJCC v7 Stage&apos; EquivalentTo &apos;Pharyngeal Carcinoma by AJCC v7 Stage&apos; and &apos;Hypopharyngeal Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91244</classIRI>
<classLabel>Nasopharyngeal Carcinoma by AJCC v7 Stage</classLabel>
<deletedAxiom>&apos;Nasopharyngeal Carcinoma by AJCC v7 Stage&apos; SubClassOf &apos;Nasopharyngeal Carcinoma&apos;</deletedAxiom>
<deletedAxiom>&apos;Nasopharyngeal Carcinoma by AJCC v7 Stage&apos; SubClassOf &apos;Pharyngeal Carcinoma by AJCC v7 Stage&apos;</deletedAxiom>
<newAxiom>&apos;Nasopharyngeal Carcinoma by AJCC v7 Stage&apos; EquivalentTo &apos;Nasopharyngeal Carcinoma&apos; and &apos;Pharyngeal Carcinoma by AJCC v7 Stage&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91248</classIRI>
<classLabel>Oropharyngeal Carcinoma by AJCC v7 Stage</classLabel>
<deletedAxiom>&apos;Oropharyngeal Carcinoma by AJCC v7 Stage&apos; SubClassOf &apos;Oropharyngeal Carcinoma&apos;</deletedAxiom>
<deletedAxiom>&apos;Oropharyngeal Carcinoma by AJCC v7 Stage&apos; SubClassOf &apos;Pharyngeal Carcinoma by AJCC v7 Stage&apos;</deletedAxiom>
<newAxiom>&apos;Oropharyngeal Carcinoma by AJCC v7 Stage&apos; EquivalentTo &apos;Oropharyngeal Carcinoma&apos; and &apos;Pharyngeal Carcinoma by AJCC v7 Stage&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52369</classIRI>
<classLabel>BCAR1 wt Allele</classLabel>
<deletedAxiom>&apos;BCAR1 wt Allele&apos; EquivalentTo &apos;BCAR1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;16: 73843004-73820430&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;16q23.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;BCAR1 wt Allele&apos; EquivalentTo &apos;BCAR1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cell to Cell Adhesion Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endothelin Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PTP4A Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;16: 73843004-73820430&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;16q23.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52381</classIRI>
<classLabel>FRS2 wt Allele</classLabel>
<deletedAxiom>&apos;FRS2 wt Allele&apos; EquivalentTo &apos;FRS2 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;12: 68150453-68255011&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q15&apos;)</deletedAxiom>
<newAxiom>&apos;FRS2 wt Allele&apos; EquivalentTo &apos;FRS2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;12: 68150453-68255011&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q15&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52386</classIRI>
<classLabel>GAB2 wt Allele</classLabel>
<deletedAxiom>&apos;GAB2 wt Allele&apos; EquivalentTo &apos;GAB2 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;11: 77806414-77603990&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11q13.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;GAB2 wt Allele&apos; EquivalentTo &apos;GAB2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;11: 77806414-77603990&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11q13.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52393</classIRI>
<classLabel>GRB14 wt Allele</classLabel>
<deletedAxiom>&apos;GRB14 wt Allele&apos; EquivalentTo &apos;GRB14 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;2: 165303867-165174840&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;2q22-q24&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;GRB14 wt Allele&apos; EquivalentTo &apos;GRB14 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;2: 165303867-165174840&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;2q22-q24&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52396</classIRI>
<classLabel>GRB7 wt Allele</classLabel>
<deletedAxiom>&apos;GRB7 wt Allele&apos; EquivalentTo &apos;GRB7 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;17: 35147744-35157063&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;17q12&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;GRB7 wt Allele&apos; EquivalentTo &apos;GRB7 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;17: 35147744-35157063&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;17q12&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52310</classIRI>
<classLabel>TRIP10 wt Allele</classLabel>
<deletedAxiom>&apos;TRIP10 wt Allele&apos; EquivalentTo &apos;TRIP10 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;19p13.3&apos;)</deletedAxiom>
<newAxiom>&apos;TRIP10 wt Allele&apos; EquivalentTo &apos;TRIP10 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin-Mediated Glucose Transport Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;19p13.3&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52466</classIRI>
<classLabel>BAG4 wt Allele</classLabel>
<deletedAxiom>&apos;BAG4 wt Allele&apos; EquivalentTo &apos;BAG4 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;8: 38153263-38187694&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;8p11.21&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;BAG4 wt Allele&apos; EquivalentTo &apos;BAG4 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;8: 38153263-38187694&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;8p11.21&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52463</classIRI>
<classLabel>AXIN1 wt Allele</classLabel>
<deletedAxiom>&apos;AXIN1 wt Allele&apos; EquivalentTo &apos;AXIN1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Notch and Wnt Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;16: 342465-277441&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;16p13.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;AXIN1 wt Allele&apos; EquivalentTo &apos;AXIN1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Notch and Wnt Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Canonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;16: 342465-277441&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;16p13.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52408</classIRI>
<classLabel>NCK2 wt Allele</classLabel>
<deletedAxiom>&apos;NCK2 wt Allele&apos; EquivalentTo &apos;NCK2 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;2q12&apos;)</deletedAxiom>
<newAxiom>&apos;NCK2 wt Allele&apos; EquivalentTo &apos;NCK2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ephrin B Reverse Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Nephrin Signaling Pathway in the Kidney Podocyte&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;2q12&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52401</classIRI>
<classLabel>ANGPT2 wt Allele</classLabel>
<deletedAxiom>&apos;ANGPT2 wt Allele&apos; EquivalentTo &apos;ANGPT2 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;8: 6408172-6347601&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;8p23.1&apos;)</deletedAxiom>
<newAxiom>&apos;ANGPT2 wt Allele&apos; EquivalentTo &apos;ANGPT2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;8: 6408172-6347601&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;8p23.1&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52406</classIRI>
<classLabel>ZFYVE9 wt Allele</classLabel>
<deletedAxiom>&apos;ZFYVE9 wt Allele&apos; EquivalentTo &apos;ZFYVE9 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 52394062-52524379&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p32.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;ZFYVE9 wt Allele&apos; EquivalentTo &apos;ZFYVE9 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 52394062-52524379&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p32.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52404</classIRI>
<classLabel>SMAD7 wt Allele</classLabel>
<deletedAxiom>&apos;SMAD7 wt Allele&apos; EquivalentTo &apos;SMAD7 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;18: 44731079-44700221&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;18q21.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;SMAD7 wt Allele&apos; EquivalentTo &apos;SMAD7 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;18: 44731079-44700221&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;18q21.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52412</classIRI>
<classLabel>EDN2 wt Allele</classLabel>
<deletedAxiom>&apos;EDN2 wt Allele&apos; EquivalentTo &apos;EDN2 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 41619390-41613540&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p34&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;EDN2 wt Allele&apos; EquivalentTo &apos;EDN2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endothelin Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 41619390-41613540&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p34&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52410</classIRI>
<classLabel>PAG1 wt Allele</classLabel>
<deletedAxiom>&apos;PAG1 wt Allele&apos; EquivalentTo &apos;PAG1 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;8q21.13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;PAG1 wt Allele&apos; EquivalentTo &apos;PAG1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;8q21.13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52415</classIRI>
<classLabel>SH2B1 wt Allele</classLabel>
<deletedAxiom>&apos;SH2B1 wt Allele&apos; EquivalentTo &apos;SH2B1 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;16p11.2&apos;)</deletedAxiom>
<newAxiom>&apos;SH2B1 wt Allele&apos; EquivalentTo &apos;SH2B1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;16p11.2&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52445</classIRI>
<classLabel>TRAF2 wt Allele</classLabel>
<deletedAxiom>&apos;TRAF2 wt Allele&apos; EquivalentTo &apos;TRAF2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;4-1BB-Dependent Immune Response Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;9q34&apos;)</deletedAxiom>
<newAxiom>&apos;TRAF2 wt Allele&apos; EquivalentTo &apos;TRAF2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;4-1BB-Dependent Immune Response Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CD40/CD40L Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TRAIL Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;9q34&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52440</classIRI>
<classLabel>TOLLIP wt Allele</classLabel>
<deletedAxiom>&apos;TOLLIP wt Allele&apos; EquivalentTo &apos;TOLLIP Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11p&apos;)</deletedAxiom>
<newAxiom>&apos;TOLLIP wt Allele&apos; EquivalentTo &apos;TOLLIP Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL1-Mediated Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11p15.5&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52435</classIRI>
<classLabel>SHC2 wt Allele</classLabel>
<deletedAxiom>&apos;SHC2 wt Allele&apos; EquivalentTo &apos;SHC2 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;19: 414665-369928&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;19p13.3&apos;)</deletedAxiom>
<newAxiom>&apos;SHC2 wt Allele&apos; EquivalentTo &apos;SHC2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;19: 414665-369928&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;19p13.3&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52438</classIRI>
<classLabel>ABI1 wt Allele</classLabel>
<deletedAxiom>&apos;ABI1 wt Allele&apos; EquivalentTo &apos;ABI1 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;10p11.2&apos;)</deletedAxiom>
<newAxiom>&apos;ABI1 wt Allele&apos; EquivalentTo &apos;ABI1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Formation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Stabilization Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;10p11.2&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52501</classIRI>
<classLabel>CBL wt Allele</classLabel>
<deletedAxiom>&apos;CBL wt Allele&apos; EquivalentTo &apos;CBL Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;11: 118582196-118675922&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11q23.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;CBL wt Allele&apos; EquivalentTo &apos;CBL Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;11: 118582196-118675922&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11q23.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52520</classIRI>
<classLabel>RHOA wt Allele</classLabel>
<deletedAxiom>&apos;RHOA wt Allele&apos; EquivalentTo &apos;RHOA Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;3: 49424403-49371582&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;3p21.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;RHOA wt Allele&apos; EquivalentTo &apos;RHOA Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cell Migration Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Calpain-1 Cell Spread Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Arf6 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Aurora B Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Class I PI3K Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;E-Cadherin Signaling Pathway in Keratinocytes&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Formation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endothelin Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Lissencephaly-1 Gene in Neuronal Migration and Development&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 5 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PTP4A Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Stabilization Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;3: 49424403-49371582&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;3p21.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52526</classIRI>
<classLabel>RHOC wt Allele</classLabel>
<deletedAxiom>&apos;RHOC wt Allele&apos; EquivalentTo &apos;RHOC Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 112961762-112955795&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p21-p13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;RHOC wt Allele&apos; EquivalentTo &apos;RHOC Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 112961762-112955795&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p21-p13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52518</classIRI>
<classLabel>EPS8 wt Allele</classLabel>
<deletedAxiom>&apos;EPS8 wt Allele&apos; EquivalentTo &apos;EPS8 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;12: 15833589-15664365&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q23-q24&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;EPS8 wt Allele&apos; EquivalentTo &apos;EPS8 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;12: 15833589-15664365&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q23-q24&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52515</classIRI>
<classLabel>DOK1 wt Allele</classLabel>
<deletedAxiom>&apos;DOK1 wt Allele&apos; EquivalentTo &apos;DOK1 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;2: 74693515-74696318&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;2p13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;DOK1 wt Allele&apos; EquivalentTo &apos;DOK1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;2: 74693515-74696318&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;2p13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52549</classIRI>
<classLabel>NRAS wt Allele</classLabel>
<deletedAxiom>&apos;NRAS wt Allele&apos; EquivalentTo &apos;NRAS Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p13.2&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;NRAS wt Allele&apos; EquivalentTo &apos;NRAS Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p13.2&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52548</classIRI>
<classLabel>MRAS wt Allele</classLabel>
<deletedAxiom>&apos;MRAS wt Allele&apos; EquivalentTo &apos;MRAS Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;3q22.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;MRAS wt Allele&apos; EquivalentTo &apos;MRAS Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;3q22.3&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52547</classIRI>
<classLabel>RAB8A wt Allele</classLabel>
<deletedAxiom>&apos;RAB8A wt Allele&apos; EquivalentTo &apos;RAB8A Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;19p13.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;RAB8A wt Allele&apos; EquivalentTo &apos;RAB8A Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Rab GTPases in Endocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;19p13.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52546</classIRI>
<classLabel>KRAS wt Allele</classLabel>
<deletedAxiom>&apos;KRAS wt Allele&apos; EquivalentTo &apos;KRAS Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;12: 25295121-25249447&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12p12.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;KRAS wt Allele&apos; EquivalentTo &apos;KRAS Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Class I PI3K Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ras Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;NTRK1/MAPK Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;12: 25295121-25249447&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12p12.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52532</classIRI>
<classLabel>RHOH wt Allele</classLabel>
<deletedAxiom>&apos;RHOH wt Allele&apos; EquivalentTo &apos;RHOH Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;4: 40021168-40068421&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;4p13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;RHOH wt Allele&apos; EquivalentTo &apos;RHOH Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;4: 40021168-40068421&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;4p13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52550</classIRI>
<classLabel>RANGAP1 wt Allele</classLabel>
<deletedAxiom>&apos;RANGAP1 wt Allele&apos; EquivalentTo &apos;RANGAP1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Protein Import into Nucleus Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Mitotic Spindle Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ran Cycling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;22q13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;RANGAP1 wt Allele&apos; EquivalentTo &apos;RANGAP1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Protein Import into Nucleus Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Mitotic Spindle Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ran Cycling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;RANBP2-Mediated Sumoylation Transcription Regulation Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;22q13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52629</classIRI>
<classLabel>GADD45A wt Allele</classLabel>
<deletedAxiom>&apos;GADD45A wt Allele&apos; EquivalentTo &apos;GADD45A Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 67862904-67866040&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p31.2-p31.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;GADD45A wt Allele&apos; EquivalentTo &apos;GADD45A Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;FOXO Transcription Factor Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway PID&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 67862904-67866040&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p31.2-p31.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52645</classIRI>
<classLabel>GNAI3 wt Allele</classLabel>
<deletedAxiom>&apos;GNAI3 wt Allele&apos; EquivalentTo &apos;GNAI3 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 109803343-109849017&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p13&apos;)</deletedAxiom>
<newAxiom>&apos;GNAI3 wt Allele&apos; EquivalentTo &apos;GNAI3 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 5 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 109803343-109849017&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p13&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52639</classIRI>
<classLabel>GNAI2 wt Allele</classLabel>
<deletedAxiom>&apos;GNAI2 wt Allele&apos; EquivalentTo &apos;GNAI2 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;3: 50248652-50271291&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;3p21&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;GNAI2 wt Allele&apos; EquivalentTo &apos;GNAI2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 5 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;3: 50248652-50271291&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;3p21&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52638</classIRI>
<classLabel>GNAI1 wt Allele</classLabel>
<deletedAxiom>&apos;GNAI1 wt Allele&apos; EquivalentTo &apos;GNAI1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;7: 79408791-79493376&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;7q21&apos;)</deletedAxiom>
<newAxiom>&apos;GNAI1 wt Allele&apos; EquivalentTo &apos;GNAI1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 5 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;7: 79408791-79493376&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;7q21&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52633</classIRI>
<classLabel>GIT1 wt Allele</classLabel>
<deletedAxiom>&apos;GIT1 wt Allele&apos; EquivalentTo &apos;GIT1 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;17: 24940735-24924620&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;17p11.2&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;GIT1 wt Allele&apos; EquivalentTo &apos;GIT1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Arf1 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Arf6 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Stabilization Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;17: 24940735-24924620&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;17p11.2&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52637</classIRI>
<classLabel>GNA12 wt Allele</classLabel>
<deletedAxiom>&apos;GNA12 wt Allele&apos; EquivalentTo &apos;GNA12 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;7: 2657200-2540984&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;7p22-p21&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;GNA12 wt Allele&apos; EquivalentTo &apos;GNA12 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 5 Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;7: 2657200-2540984&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;7p22-p21&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52634</classIRI>
<classLabel>GIT2 wt Allele</classLabel>
<deletedAxiom>&apos;GIT2 wt Allele&apos; EquivalentTo &apos;GIT2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;12: 108896820-108830329&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q24.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;GIT2 wt Allele&apos; EquivalentTo &apos;GIT2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;12: 108896820-108830329&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q24.1&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52672</classIRI>
<classLabel>GNB2 wt Allele</classLabel>
<deletedAxiom>&apos;GNB2 wt Allele&apos; EquivalentTo &apos;GNB2 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;7: 99916026-99921443&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;7q22&apos;)</deletedAxiom>
<newAxiom>&apos;GNB2 wt Allele&apos; EquivalentTo &apos;GNB2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;7: 99916026-99921443&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;7q22&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52806</classIRI>
<classLabel>ILK wt Allele</classLabel>
<deletedAxiom>&apos;ILK wt Allele&apos; EquivalentTo &apos;ILK Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;11: 6581588-6588677&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11p15.5-p15.4&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;ILK wt Allele&apos; EquivalentTo &apos;ILK Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;11: 6581588-6588677&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11p15.5-p15.4&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52804</classIRI>
<classLabel>IL6ST wt Allele</classLabel>
<deletedAxiom>&apos;IL6ST wt Allele&apos; EquivalentTo &apos;IL6ST Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;5: 55326520-55272452&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;5q11&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;IL6ST wt Allele&apos; EquivalentTo &apos;IL6ST Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL27-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;5: 55326520-55272452&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;5q11&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52820</classIRI>
<classLabel>SMAD3 wt Allele</classLabel>
<deletedAxiom>&apos;SMAD3 wt Allele&apos; EquivalentTo &apos;SMAD3 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;15: 65145331-65270904&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;15q22.33&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;SMAD3 wt Allele&apos; EquivalentTo &apos;SMAD3 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Regulation of Cytoplasmic and Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;15: 65145331-65270904&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;15q22.33&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52811</classIRI>
<classLabel>IRAK4 wt Allele</classLabel>
<deletedAxiom>&apos;IRAK4 wt Allele&apos; EquivalentTo &apos;IRAK4 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;12: 42439047-42468166&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q12&apos;)</deletedAxiom>
<newAxiom>&apos;IRAK4 wt Allele&apos; EquivalentTo &apos;IRAK4 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;12: 42439047-42468166&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q12&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52882</classIRI>
<classLabel>NF1 wt Allele</classLabel>
<deletedAxiom>&apos;NF1 wt Allele&apos; EquivalentTo &apos;NF1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;hSWI-SNF Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;17q11.2&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;NF1 wt Allele&apos; EquivalentTo &apos;NF1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;hSWI-SNF Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;FOXA2 and FOXA3 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;17q11.2&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52880</classIRI>
<classLabel>MFNG wt Allele</classLabel>
<deletedAxiom>&apos;MFNG wt Allele&apos; EquivalentTo &apos;MFNG Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;22q12&apos;)</deletedAxiom>
<newAxiom>&apos;MFNG wt Allele&apos; EquivalentTo &apos;MFNG Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;O-Mannosyl Glycan Biosynthesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;22q12&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52897</classIRI>
<classLabel>NFKBIE wt Allele</classLabel>
<deletedAxiom>&apos;NFKBIE wt Allele&apos; EquivalentTo &apos;NFKBIE Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;6p21.1&apos;)</deletedAxiom>
<newAxiom>&apos;NFKBIE wt Allele&apos; EquivalentTo &apos;NFKBIE Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;6p21.1&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52926</classIRI>
<classLabel>RGS2 wt Allele</classLabel>
<deletedAxiom>&apos;RGS2 wt Allele&apos; EquivalentTo &apos;RGS2 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 189509828-189513060&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1q31&apos;)</deletedAxiom>
<newAxiom>&apos;RGS2 wt Allele&apos; EquivalentTo &apos;RGS2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 189509828-189513060&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1q31&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52922</classIRI>
<classLabel>RGS1 wt Allele</classLabel>
<deletedAxiom>&apos;RGS1 wt Allele&apos; EquivalentTo &apos;RGS1 Gene&apos; and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 189276582-189280811&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1q31&apos;)</deletedAxiom>
<newAxiom>&apos;RGS1 wt Allele&apos; EquivalentTo &apos;RGS1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 189276582-189280811&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1q31&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52915</classIRI>
<classLabel>RASGRF2 wt Allele</classLabel>
<deletedAxiom>&apos;RASGRF2 wt Allele&apos; EquivalentTo &apos;RASGRF2 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;5q13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;RASGRF2 wt Allele&apos; EquivalentTo &apos;RASGRF2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;5q13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52932</classIRI>
<classLabel>SEMA3E wt Allele</classLabel>
<deletedAxiom>&apos;SEMA3E wt Allele&apos; EquivalentTo &apos;SEMA3E Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;7q21.11&apos;)</deletedAxiom>
<newAxiom>&apos;SEMA3E wt Allele&apos; EquivalentTo &apos;SEMA3E Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;7q21.11&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52964</classIRI>
<classLabel>VAV3 wt Allele</classLabel>
<deletedAxiom>&apos;VAV3 wt Allele&apos; EquivalentTo &apos;VAV3 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p13.2&apos;)</deletedAxiom>
<newAxiom>&apos;VAV3 wt Allele&apos; EquivalentTo &apos;VAV3 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p13.2&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52957</classIRI>
<classLabel>VAV1 wt Allele</classLabel>
<deletedAxiom>&apos;VAV1 wt Allele&apos; EquivalentTo &apos;VAV1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Phospholipase C Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;19p13.2&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;VAV1 wt Allele&apos; EquivalentTo &apos;VAV1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Phospholipase C Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;19p13.2&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52982</classIRI>
<classLabel>WNT11 wt Allele</classLabel>
<deletedAxiom>&apos;WNT11 wt Allele&apos; EquivalentTo &apos;WNT11 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11q13.5&apos;)</deletedAxiom>
<newAxiom>&apos;WNT11 wt Allele&apos; EquivalentTo &apos;WNT11 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11q13.5&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52979</classIRI>
<classLabel>WNT10B wt Allele</classLabel>
<deletedAxiom>&apos;WNT10B wt Allele&apos; EquivalentTo &apos;WNT10B Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;WNT10B wt Allele&apos; EquivalentTo &apos;WNT10B Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;12q13&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52977</classIRI>
<classLabel>WNT10A wt Allele</classLabel>
<deletedAxiom>&apos;WNT10A wt Allele&apos; EquivalentTo &apos;WNT10A Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;2: 219570760-219584156&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;2q35&apos;)</deletedAxiom>
<newAxiom>&apos;WNT10A wt Allele&apos; EquivalentTo &apos;WNT10A Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;2: 219570760-219584156&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;2q35&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52999</classIRI>
<classLabel>WNT4 wt Allele</classLabel>
<deletedAxiom>&apos;WNT4 wt Allele&apos; EquivalentTo &apos;WNT4 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p35&apos;)</deletedAxiom>
<newAxiom>&apos;WNT4 wt Allele&apos; EquivalentTo &apos;WNT4 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p36.12&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52990</classIRI>
<classLabel>WNT2 wt Allele</classLabel>
<deletedAxiom>&apos;WNT2 wt Allele&apos; EquivalentTo &apos;WNT2 Gene&apos; and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;7q31&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;WNT2 wt Allele&apos; EquivalentTo &apos;WNT2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Basal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;7q31&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9221</classIRI>
<classLabel>Recurrent Childhood Malignant Germ Cell Tumor</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Malignant Germ Cell Tumor&apos; EquivalentTo &apos;Recurrent Primary Malignant Neoplasm&apos; and &apos;Malignant Childhood Germ Cell Tumor&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Malignant Germ Cell Tumor&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132853 and &apos;Malignant Childhood Germ Cell Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9190</classIRI>
<classLabel>Recurrent Childhood Brain Stem Glioma</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Brain Stem Glioma&apos; EquivalentTo &apos;Recurrent Childhood Brain Neoplasm&apos; and &apos;Childhood Brain Stem Glioma&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Brain Stem Glioma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506 and &apos;Recurrent Childhood Brain Neoplasm&apos; and &apos;Childhood Brain Stem Glioma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33955</classIRI>
<classLabel>RAS-Related Protein MRAS</classLabel>
<deletedAxiom>&apos;RAS-Related Protein MRAS&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MRAS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAS-Related Protein MRAS&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MRAS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33963</classIRI>
<classLabel>NCK Adaptor Protein 2</classLabel>
<deletedAxiom>&apos;NCK Adaptor Protein 2&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NCK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NCK Adaptor Protein 2&apos; EquivalentTo &apos;Adaptor Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Reverse Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nephrin Signaling Pathway in the Kidney Podocyte&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NCK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33994</classIRI>
<classLabel>Palmitoylated Membrane Protein 2</classLabel>
<deletedAxiom>&apos;Palmitoylated Membrane Protein 2&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MPP2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Palmitoylated Membrane Protein 2&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Scaffolding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MPP2 Gene&apos;)</newAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132793</classIRI>
<classLabel>Nasopharyngeal Cancer Clinical TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer Clinical TNM Finding v8' SubClassOf 'Head and Neck Cancer Clinical TNM Finding v8'</newAxiom>
<newAxiom>'Nasopharyngeal Cancer Clinical TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132792</classIRI>
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<newAxiom>'Lip and Oral Cavity Cancer cN2b TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer cN2 TNM Finding v8'</newAxiom>
</newClass>
<newClass>
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<classLabel>Lip and Oral Cavity Cancer cN2a TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer cN2a TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer cN2 TNM Finding v8'</newAxiom>
</newClass>
<newClass>
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<newAxiom>'Lip and Oral Cavity Cancer cN3 TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer Clinical Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
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<classLabel>Lip and Oral Cavity Cancer cN2c TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer cN2c TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer cN2 TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132719</classIRI>
<classLabel>Lip and Oral Cavity Cancer cN3b TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer cN3b TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer cN3 TNM Finding v8'</newAxiom>
</newClass>
<newClass>
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<classLabel>Lip and Oral Cavity Cancer cN3a TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer cN3a TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer cN3 TNM Finding v8'</newAxiom>
</newClass>
<newClass>
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<classLabel>Lip and Oral Cavity Cancer pN3b TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer pN3b TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer pN3 TNM Finding v8'</newAxiom>
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<newClass>
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</newClass>
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<newClass>
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</newClass>
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<classLabel>Lip and Oral Cavity Cancer pN1 TNM Finding v8</classLabel>
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</newClass>
<newClass>
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<classLabel>Lip and Oral Cavity Cancer pN0 TNM Finding v8</classLabel>
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</newClass>
<newClass>
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<classLabel>Lip and Oral Cavity Cancer pN2a TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer pN2a TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer pN2 TNM Finding v8'</newAxiom>
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<newClass>
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<classLabel>Lip and Oral Cavity Cancer pN2 TNM Finding v8</classLabel>
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</newClass>
<newClass>
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<classLabel>Lip and Oral Cavity Cancer pN2c TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer pN2c TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer pN2 TNM Finding v8'</newAxiom>
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<newClass>
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<classLabel>Lip and Oral Cavity Cancer pN2b TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer pN2b TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer pN2 TNM Finding v8'</newAxiom>
</newClass>
<newClass>
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<classLabel>Lip and Oral Cavity Cancer pT4b TNM Finding v8</classLabel>
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<classLabel>Lip and Oral Cavity Cancer pN3 TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer pN3 TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
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<classLabel>Stage IVC Lip and Oral Cavity Cancer AJCC v8</classLabel>
<newAxiom>'Stage IVC Lip and Oral Cavity Cancer AJCC v8' EquivalentTo 'Stage IV Lip and Oral Cavity Cancer AJCC v8' and ('Disease_Is_Stage' some 'Stage IVC')</newAxiom>
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<newClass>
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<newAxiom>'Stage IVB Lip and Oral Cavity Cancer AJCC v8' EquivalentTo 'Stage IV Lip and Oral Cavity Cancer AJCC v8' and ('Disease_Is_Stage' some 'Stage IVB')</newAxiom>
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<newClass>
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<classLabel>Intracanalicular Route of Administration</classLabel>
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<newClass>
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<classLabel>Lip and Oral Cavity Cancer by AJCC v6 and v7 Stage</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer by AJCC v6 and v7 Stage' EquivalentTo 'Lip and Oral Cavity Carcinoma' and ('Disease_Is_Stage' some 'AJCC v6 Stage') and ('Disease_Is_Stage' some 'AJCC v7 Stage')</newAxiom>
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<classLabel>Major Salivary Gland Cancer TNM Finding v8</classLabel>
<newAxiom>'Major Salivary Gland Cancer TNM Finding v8' SubClassOf 'Head and Neck Cancer TNM Finding v8'</newAxiom>
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<classLabel>Abediterol</classLabel>
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<classLabel>Stage III Lip and Oral Cavity Cancer AJCC v8</classLabel>
<newAxiom>'Stage III Lip and Oral Cavity Cancer AJCC v8' EquivalentTo 'Lip and Oral Cavity Cancer by AJCC v8 Stage' and ('Disease_Is_Stage' some 'Stage III')</newAxiom>
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<classLabel>Stage II Lip and Oral Cavity Cancer AJCC v8</classLabel>
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<classLabel>Stage IVA Lip and Oral Cavity Cancer AJCC v8</classLabel>
<newAxiom>'Stage IVA Lip and Oral Cavity Cancer AJCC v8' EquivalentTo 'Stage IV Lip and Oral Cavity Cancer AJCC v8' and ('Disease_Is_Stage' some 'Stage IVA')</newAxiom>
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<classLabel>Stage IV Lip and Oral Cavity Cancer AJCC v8</classLabel>
<newAxiom>'Stage IV Lip and Oral Cavity Cancer AJCC v8' EquivalentTo 'Lip and Oral Cavity Cancer by AJCC v8 Stage' and ('Disease_Is_Stage' some 'Stage IV')</newAxiom>
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<classLabel>Lip and Oral Cavity Cancer cM1 TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer cM1 TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer Clinical Distant Metastasis TNM Finding v8'</newAxiom>
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<classLabel>Lip and Oral Cavity Cancer cM0 TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer cM0 TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer Clinical Distant Metastasis TNM Finding v8'</newAxiom>
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<classLabel>Myelosuppressive Chemotherapy</classLabel>
<newAxiom>'Myelosuppressive Chemotherapy' SubClassOf 'Myelosuppressive Therapy'</newAxiom>
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<newClass>
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<classLabel>Vabicaserin</classLabel>
<newAxiom>'Vabicaserin' SubClassOf 'Anorexiant'</newAxiom>
<newAxiom>'Vabicaserin' SubClassOf 'Serotonin Agonist'</newAxiom>
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<classLabel>Lip and Oral Cavity Cancer by AJCC v8 Stage</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer by AJCC v8 Stage' EquivalentTo 'Lip and Oral Cavity Carcinoma' and ('Disease_Is_Stage' some 'AJCC v8 Stage')</newAxiom>
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<classLabel>Cerebral Vein Thrombosis</classLabel>
<newAxiom>'Cerebral Vein Thrombosis' SubClassOf 'Venous Thrombosis'</newAxiom>
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<classLabel>Stage I Lip and Oral Cavity Cancer AJCC v8</classLabel>
<newAxiom>'Stage I Lip and Oral Cavity Cancer AJCC v8' EquivalentTo 'Lip and Oral Cavity Cancer by AJCC v8 Stage' and ('Disease_Is_Stage' some 'Stage I')</newAxiom>
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<classLabel>Lip and Oral Cavity Cancer Pathologic Distant Metastasis TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer Pathologic Distant Metastasis TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer Pathologic TNM Finding v8'</newAxiom>
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<classLabel>Lip and Oral Cavity Cancer Clinical Distant Metastasis TNM Finding v8</classLabel>
<newAxiom>'Lip and Oral Cavity Cancer Clinical Distant Metastasis TNM Finding v8' SubClassOf 'Lip and Oral Cavity Cancer Clinical TNM Finding v8'</newAxiom>
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<classLabel>Lip and Oral Cavity Cancer pM1 TNM Finding v8</classLabel>
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<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical Distant Metastasis TNM Finding v8</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical Distant Metastasis TNM Finding v8' SubClassOf 'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical TNM Finding v8'</newAxiom>
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<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer pM1 TNM Finding v8</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer pM1 TNM Finding v8' SubClassOf 'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Pathologic Distant Metastasis TNM Finding v8'</newAxiom>
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<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer cM0 TNM Finding v8</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer cM0 TNM Finding v8' SubClassOf 'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical Distant Metastasis TNM Finding v8'</newAxiom>
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<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer pN1 TNM Finding v8</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer pN1 TNM Finding v8' SubClassOf 'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
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<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical Regional Lymph Nodes TNM Finding v8</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical Regional Lymph Nodes TNM Finding v8' SubClassOf 'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical TNM Finding v8'</newAxiom>
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<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer pN2 TNM Finding v8</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer pN2 TNM Finding v8' SubClassOf 'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
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<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer cN2 TNM Finding v8</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer cN2 TNM Finding v8' SubClassOf 'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical Regional Lymph Nodes TNM Finding v8'</newAxiom>
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<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical TNM Finding v8</classLabel>
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<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical TNM Finding v8' SubClassOf 'Head and Neck Cancer Clinical TNM Finding v8'</newAxiom>
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<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer pT1 TNM Finding v8</classLabel>
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<classLabel>Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8' EquivalentTo 'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Pathologic Stage' and 'Stage II Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage II')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132892</classIRI>
<classLabel>Unmethylated MGMT Promoter</classLabel>
<newAxiom>'Unmethylated MGMT Promoter' SubClassOf 'Genetic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132891</classIRI>
<classLabel>Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8' EquivalentTo 'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Clinical Stage' and 'Stage III Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage III')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132894</classIRI>
<classLabel>PIK3R1 Gene Mutation</classLabel>
<newAxiom>'PIK3R1 Gene Mutation' SubClassOf 'Gene Mutant'</newAxiom>
<newAxiom>'PIK3R1 Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'PIK3R1 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132893</classIRI>
<classLabel>Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8' EquivalentTo 'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Clinical Stage' and 'Stage IV Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IV')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132896</classIRI>
<classLabel>PIK3C2B Gene Amplification</classLabel>
<newAxiom>'PIK3C2B Gene Amplification' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'PIK3C2B Gene'</newAxiom>
<newAxiom>'PIK3C2B Gene Amplification' SubClassOf 'Gene Amplification Abnormality'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132895</classIRI>
<classLabel>AKT3 Gene Amplification</classLabel>
<newAxiom>'AKT3 Gene Amplification' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'AKT3 Gene'</newAxiom>
<newAxiom>'AKT3 Gene Amplification' SubClassOf 'Gene Amplification Abnormality'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132898</classIRI>
<classLabel>Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8' EquivalentTo 'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Pathologic Stage' and 'Stage I Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage I')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132897</classIRI>
<classLabel>CDK6 Gene Amplification</classLabel>
<newAxiom>'CDK6 Gene Amplification' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'CDK6 Gene'</newAxiom>
<newAxiom>'CDK6 Gene Amplification' SubClassOf 'Gene Amplification Abnormality'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132889</classIRI>
<classLabel>MIR124-2 Pre-miRNA</classLabel>
<newAxiom>'MIR124-2 Pre-miRNA' SubClassOf 'Pre-miRNA'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132888</classIRI>
<classLabel>MIR124-2 wt Allele</classLabel>
<newAxiom>'MIR124-2 wt Allele' SubClassOf 'MIR124-2 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132881</classIRI>
<classLabel>Metastatic Prostate Carcinoma in the Soft Tissue</classLabel>
<newAxiom>'Metastatic Prostate Carcinoma in the Soft Tissue' EquivalentTo 'Metastatic Prostate Carcinoma' and ('Disease_Has_Metastatic_Anatomic_Site' some 'Soft Tissue')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132880</classIRI>
<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer cM1 TNM Finding v8</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer cM1 TNM Finding v8' SubClassOf 'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Clinical Distant Metastasis TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132883</classIRI>
<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Clinical Stage</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Clinical Stage' EquivalentTo 'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Stage' and ('Disease_Excludes_Finding' some 'Pathology Result')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132882</classIRI>
<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Stage</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Stage' EquivalentTo 'Pharyngeal Carcinoma by AJCC v8 Stage' and 'Oropharyngeal Carcinoma' and ('Disease_Has_Finding' some 'Human Papillomavirus Positive') and ('Disease_Has_Associated_Disease' some 'Human Papillomavirus Infection')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132885</classIRI>
<classLabel>Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8' EquivalentTo 'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Clinical Stage' and 'Stage I Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage I')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132884</classIRI>
<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Pathologic Stage</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Pathologic Stage' EquivalentTo 'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Stage' and ('Disease_Has_Finding' some 'Pathology Result')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132887</classIRI>
<classLabel>MIR124-2 Gene</classLabel>
<newAxiom>'MIR124-2 Gene' SubClassOf 'MicroRNA Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132886</classIRI>
<classLabel>Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8' EquivalentTo 'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Clinical Stage' and 'Stage II Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage II')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132890</classIRI>
<classLabel>Immune Cell</classLabel>
<newAxiom>'Immune Cell' SubClassOf 'Anatomic_Structure_Is_Physical_Part_Of' some 'Immune System'</newAxiom>
<newAxiom>'Immune Cell' SubClassOf 'Hematopoietic and Lymphoid Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132834</classIRI>
<classLabel>Distress Score 5</classLabel>
<newAxiom>'Distress Score 5' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132833</classIRI>
<classLabel>Distress Score 4</classLabel>
<newAxiom>'Distress Score 4' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132836</classIRI>
<classLabel>Distress Score 7</classLabel>
<newAxiom>'Distress Score 7' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132835</classIRI>
<classLabel>Distress Score 6</classLabel>
<newAxiom>'Distress Score 6' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132838</classIRI>
<classLabel>Distress Score 9</classLabel>
<newAxiom>'Distress Score 9' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132837</classIRI>
<classLabel>Distress Score 8</classLabel>
<newAxiom>'Distress Score 8' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132839</classIRI>
<classLabel>Distress Score 10</classLabel>
<newAxiom>'Distress Score 10' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132830</classIRI>
<classLabel>Distress Score 1</classLabel>
<newAxiom>'Distress Score 1' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132832</classIRI>
<classLabel>Distress Score 3</classLabel>
<newAxiom>'Distress Score 3' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132831</classIRI>
<classLabel>Distress Score 2</classLabel>
<newAxiom>'Distress Score 2' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132823</classIRI>
<classLabel>Canine Oral Squamous Cell Carcinoma</classLabel>
<newAxiom>'Canine Oral Squamous Cell Carcinoma' SubClassOf 'Experimental Organism Diagnosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132822</classIRI>
<classLabel>Stage IVB Nasopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage IVB Nasopharyngeal Carcinoma AJCC v8' EquivalentTo 'Stage IV Nasopharyngeal Carcinoma AJCC v8' and 'Stage IVB Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IVB')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132825</classIRI>
<classLabel>Feline Osteosarcoma</classLabel>
<newAxiom>'Feline Osteosarcoma' SubClassOf 'Experimental Organism Diagnosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132824</classIRI>
<classLabel>Feline Oral Squamous Cell Carcinoma</classLabel>
<newAxiom>'Feline Oral Squamous Cell Carcinoma' SubClassOf 'Experimental Organism Diagnosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132827</classIRI>
<classLabel>Autosomal Recessive Congenital Ichthyosis 2</classLabel>
<newAxiom>'Autosomal Recessive Congenital Ichthyosis 2' SubClassOf 'Ichthyosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132826</classIRI>
<classLabel>Distal Hereditary Motor Neuronopathy Type I</classLabel>
<newAxiom>'Distal Hereditary Motor Neuronopathy Type I' SubClassOf 'Charcot-Marie-Tooth Disease'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132829</classIRI>
<classLabel>Distress Score 0</classLabel>
<newAxiom>'Distress Score 0' SubClassOf 'Distress Score Visual Analogue Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132828</classIRI>
<classLabel>Distress Score Visual Analogue Scale</classLabel>
<newAxiom>'Distress Score Visual Analogue Scale' SubClassOf 'Visual Analog Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132821</classIRI>
<classLabel>Stage IVA Nasopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage IVA Nasopharyngeal Carcinoma AJCC v8' EquivalentTo 'Stage IV Nasopharyngeal Carcinoma AJCC v8' and 'Stage IVA Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IVA')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132820</classIRI>
<classLabel>Stage IV Nasopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage IV Nasopharyngeal Carcinoma AJCC v8' EquivalentTo 'Nasopharyngeal Carcinoma by AJCC v8 Stage' and 'Stage IV Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IV')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132856</classIRI>
<classLabel>Herpes Simplex Virus 2 DNA (Presence)</classLabel>
<newAxiom>'Herpes Simplex Virus 2 DNA (Presence)' SubClassOf 'Molecular Analysis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132855</classIRI>
<classLabel>Herpes Simplex Virus 1 DNA (Presence)</classLabel>
<newAxiom>'Herpes Simplex Virus 1 DNA (Presence)' SubClassOf 'Molecular Analysis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132858</classIRI>
<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer TNM Finding v8</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer TNM Finding v8' SubClassOf 'Pharyngeal Cancer TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132857</classIRI>
<classLabel>Herpes Virus 6 DNA (Presence)</classLabel>
<newAxiom>'Herpes Virus 6 DNA (Presence)' SubClassOf 'Molecular Analysis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132859</classIRI>
<classLabel>HPV-Mediated (p16-Positive) Oropharyngeal Cancer Pathologic TNM Finding v8</classLabel>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Pathologic TNM Finding v8' SubClassOf 'HPV-Mediated (p16-Positive) Oropharyngeal Cancer TNM Finding v8'</newAxiom>
<newAxiom>'HPV-Mediated (p16-Positive) Oropharyngeal Cancer Pathologic TNM Finding v8' SubClassOf 'Head and Neck Cancer Pathologic TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132850</classIRI>
<classLabel>Unresectable Osteosarcoma</classLabel>
<newAxiom>'Unresectable Osteosarcoma' EquivalentTo 'Unresectable Malignant Neoplasm' and 'Osteosarcoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132852</classIRI>
<classLabel>Respiratory Pathogen Panel</classLabel>
<newAxiom>'Respiratory Pathogen Panel' SubClassOf 'Molecular Analysis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132851</classIRI>
<classLabel>CD47 Antagonist ALX148</classLabel>
<newAxiom>'CD47 Antagonist ALX148' SubClassOf 'Antineoplastic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132854</classIRI>
<classLabel>Metastatic Germ Cell Tumor</classLabel>
<newAxiom>'Metastatic Germ Cell Tumor' EquivalentTo 'Metastatic Malignant Neoplasm' and 'Malignant Germ Cell Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132853</classIRI>
<classLabel>Recurrent Germ Cell Tumor</classLabel>
<newAxiom>'Recurrent Germ Cell Tumor' EquivalentTo 'Recurrent Malignant Neoplasm' and 'Malignant Germ Cell Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132845</classIRI>
<classLabel>6,7-Epidrospirenone</classLabel>
<newAxiom>'6,7-Epidrospirenone' SubClassOf 'Progestin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132844</classIRI>
<classLabel>Technetium Tc 99m Lidofenin</classLabel>
<newAxiom>'Technetium Tc 99m Lidofenin' SubClassOf 'Radioconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132847</classIRI>
<classLabel>RAS Wild Type</classLabel>
<newAxiom>'RAS Wild Type' SubClassOf 'Genetic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132846</classIRI>
<classLabel>Almagodrate</classLabel>
<newAxiom>'Almagodrate' SubClassOf 'Anti-ulcer Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132849</classIRI>
<classLabel>Unresectable Ewing Sarcoma</classLabel>
<newAxiom>'Unresectable Ewing Sarcoma' EquivalentTo 'Unresectable Malignant Neoplasm' and 'Ewing Sarcoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132848</classIRI>
<classLabel>RAF Wild Type</classLabel>
<newAxiom>'RAF Wild Type' SubClassOf 'Genetic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132841</classIRI>
<classLabel>Imeglimin</classLabel>
<newAxiom>'Imeglimin' SubClassOf 'Anti-diabetic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132840</classIRI>
<classLabel>Suicide Gene</classLabel>
<newAxiom>'Suicide Gene' SubClassOf 'Miscellaneous Molecular Biology Terms'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132843</classIRI>
<classLabel>Pentiapine</classLabel>
<newAxiom>'Pentiapine' SubClassOf 'Antipsychotic Agent'</newAxiom>
<newAxiom>'Pentiapine' SubClassOf 'Dopamine Antagonist'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132842</classIRI>
<classLabel>Auriclosene</classLabel>
<newAxiom>'Auriclosene' SubClassOf 'Topical Anti-Infective Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132812</classIRI>
<classLabel>Nasopharyngeal Cancer cM0 TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer cM0 TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Clinical Distant Metastasis TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132811</classIRI>
<classLabel>Nasopharyngeal Cancer Clinical Distant Metastasis TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer Clinical Distant Metastasis TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Clinical TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132814</classIRI>
<classLabel>Pharyngeal Carcinoma by AJCC v8 Stage</classLabel>
<newAxiom>'Pharyngeal Carcinoma by AJCC v8 Stage' EquivalentTo 'Pharyngeal Carcinoma' and ('Disease_Is_Stage' some 'AJCC v8 Stage')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132813</classIRI>
<classLabel>Nasopharyngeal Cancer cM1 TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer cM1 TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Clinical Distant Metastasis TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132816</classIRI>
<classLabel>Nasopharyngeal Carcinoma by AJCC v8 Stage</classLabel>
<newAxiom>'Nasopharyngeal Carcinoma by AJCC v8 Stage' EquivalentTo 'Pharyngeal Carcinoma by AJCC v8 Stage' and 'Nasopharyngeal Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132815</classIRI>
<classLabel>Stage 0 Nasopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage 0 Nasopharyngeal Carcinoma AJCC v8' EquivalentTo 'Nasopharyngeal Carcinoma by AJCC v8 Stage' and 'Stage 0 Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage 0')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132818</classIRI>
<classLabel>Stage II Nasopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage II Nasopharyngeal Carcinoma AJCC v8' EquivalentTo 'Nasopharyngeal Carcinoma by AJCC v8 Stage' and 'Stage II Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage II')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132817</classIRI>
<classLabel>Stage I Nasopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage I Nasopharyngeal Carcinoma AJCC v8' EquivalentTo 'Nasopharyngeal Carcinoma by AJCC v8 Stage' and 'Stage I Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage I')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132810</classIRI>
<classLabel>Nasopharyngeal Cancer pM1 TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer pM1 TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic Distant Metastasis TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132819</classIRI>
<classLabel>Stage III Nasopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage III Nasopharyngeal Carcinoma AJCC v8' EquivalentTo 'Nasopharyngeal Carcinoma by AJCC v8 Stage' and 'Stage III Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage III')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132801</classIRI>
<classLabel>Nasopharyngeal Cancer pT4 TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer pT4 TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132800</classIRI>
<classLabel>Nasopharyngeal Cancer pT3 TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer pT3 TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132803</classIRI>
<classLabel>Nasopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132802</classIRI>
<classLabel>Nasopharyngeal Cancer pTis TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer pTis TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132805</classIRI>
<classLabel>Nasopharyngeal Cancer pN0 TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer pN0 TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132804</classIRI>
<classLabel>Nasopharyngeal Cancer pNX TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer pNX TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132807</classIRI>
<classLabel>Nasopharyngeal Cancer pN2 TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer pN2 TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132806</classIRI>
<classLabel>Nasopharyngeal Cancer pN1 TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer pN1 TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132809</classIRI>
<classLabel>Nasopharyngeal Cancer Pathologic Distant Metastasis TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer Pathologic Distant Metastasis TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132808</classIRI>
<classLabel>Nasopharyngeal Cancer pN3 TNM Finding v8</classLabel>
<newAxiom>'Nasopharyngeal Cancer pN3 TNM Finding v8' SubClassOf 'Nasopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132559</classIRI>
<classLabel>CES - Soldiers in Unit Killed (KIA), Wounded, Missing (MIA)</classLabel>
<newAxiom>'CES - Soldiers in Unit Killed (KIA), Wounded, Missing (MIA)' SubClassOf 'CES Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132558</classIRI>
<classLabel>CES - Ever Surrounded by the Enemy</classLabel>
<newAxiom>'CES - Ever Surrounded by the Enemy' SubClassOf 'CES Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132551</classIRI>
<classLabel>NSAA - Hop Right Leg</classLabel>
<newAxiom>'NSAA - Hop Right Leg' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132550</classIRI>
<classLabel>NSAA - Jump</classLabel>
<newAxiom>'NSAA - Jump' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132553</classIRI>
<classLabel>NSAA - Run (10m)</classLabel>
<newAxiom>'NSAA - Run (10m)' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132552</classIRI>
<classLabel>NSAA - Hop Left Leg</classLabel>
<newAxiom>'NSAA - Hop Left Leg' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132555</classIRI>
<classLabel>NSAA - Total</classLabel>
<newAxiom>'NSAA - Total' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132554</classIRI>
<classLabel>NSAA - Run (10m) Time</classLabel>
<newAxiom>'NSAA - Run (10m) Time' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132557</classIRI>
<classLabel>CES - Were You Ever Under Enemy Fire</classLabel>
<newAxiom>'CES - Were You Ever Under Enemy Fire' SubClassOf 'CES Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132556</classIRI>
<classLabel>CES - Ever Combat Patrols or Dangerous Duty</classLabel>
<newAxiom>'CES - Ever Combat Patrols or Dangerous Duty' SubClassOf 'CES Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132560</classIRI>
<classLabel>CES - How Often Fire Rounds at Enemy</classLabel>
<newAxiom>'CES - How Often Fire Rounds at Enemy' SubClassOf 'CES Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132548</classIRI>
<classLabel>NSAA - Lifts Head</classLabel>
<newAxiom>'NSAA - Lifts Head' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132547</classIRI>
<classLabel>NSAA - Rise From Floor Time</classLabel>
<newAxiom>'NSAA - Rise From Floor Time' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132549</classIRI>
<classLabel>NSAA - Stands on Heels</classLabel>
<newAxiom>'NSAA - Stands on Heels' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132540</classIRI>
<classLabel>NSAA - Stand on One Leg - Left</classLabel>
<newAxiom>'NSAA - Stand on One Leg - Left' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132542</classIRI>
<classLabel>NSAA - Climb Box Step - Left</classLabel>
<newAxiom>'NSAA - Climb Box Step - Left' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132541</classIRI>
<classLabel>NSAA - Climb Box Step - Right</classLabel>
<newAxiom>'NSAA - Climb Box Step - Right' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132544</classIRI>
<classLabel>NSAA - Descend Box Step - Left</classLabel>
<newAxiom>'NSAA - Descend Box Step - Left' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132543</classIRI>
<classLabel>NSAA - Descend Box Step - Right</classLabel>
<newAxiom>'NSAA - Descend Box Step - Right' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132546</classIRI>
<classLabel>NSAA - Rise From Floor</classLabel>
<newAxiom>'NSAA - Rise From Floor' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132545</classIRI>
<classLabel>NSAA - Gets to Sitting</classLabel>
<newAxiom>'NSAA - Gets to Sitting' SubClassOf 'NSAA Clinical Classification Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132573</classIRI>
<classLabel>HAQ-DI Without VAS - Dress Yourself</classLabel>
<newAxiom>'HAQ-DI Without VAS - Dress Yourself' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132572</classIRI>
<classLabel>EPDS - Thought of Harming Myself</classLabel>
<newAxiom>'EPDS - Thought of Harming Myself' SubClassOf 'EPDS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132575</classIRI>
<classLabel>HAQ-DI Without VAS - Stand Up From a Straight Chair</classLabel>
<newAxiom>'HAQ-DI Without VAS - Stand Up From a Straight Chair' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132574</classIRI>
<classLabel>HAQ-DI Without VAS - Shampoo Your Hair</classLabel>
<newAxiom>'HAQ-DI Without VAS - Shampoo Your Hair' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132577</classIRI>
<classLabel>HAQ-DI Without VAS - Cut Your Meat</classLabel>
<newAxiom>'HAQ-DI Without VAS - Cut Your Meat' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132576</classIRI>
<classLabel>HAQ-DI Without VAS - Get In and Out of Bed</classLabel>
<newAxiom>'HAQ-DI Without VAS - Get In and Out of Bed' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132579</classIRI>
<classLabel>HAQ-DI Without VAS - Open a New Milk Carton</classLabel>
<newAxiom>'HAQ-DI Without VAS - Open a New Milk Carton' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132578</classIRI>
<classLabel>HAQ-DI Without VAS - Lift a Full Cup or Glass to Mouth</classLabel>
<newAxiom>'HAQ-DI Without VAS - Lift a Full Cup or Glass to Mouth' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132580</classIRI>
<classLabel>HAQ-DI Without VAS - Walk Outdoors on Flat Ground</classLabel>
<newAxiom>'HAQ-DI Without VAS - Walk Outdoors on Flat Ground' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132582</classIRI>
<classLabel>HAQ-DI Without VAS - Aid: Cane</classLabel>
<newAxiom>'HAQ-DI Without VAS - Aid: Cane' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132581</classIRI>
<classLabel>HAQ-DI Without VAS - Climb Up Five Steps</classLabel>
<newAxiom>'HAQ-DI Without VAS - Climb Up Five Steps' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132569</classIRI>
<classLabel>EPDS - Unhappy Had Difficulty Sleeping</classLabel>
<newAxiom>'EPDS - Unhappy Had Difficulty Sleeping' SubClassOf 'EPDS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132562</classIRI>
<classLabel>CES - In Danger of Being Injured or Killed</classLabel>
<newAxiom>'CES - In Danger of Being Injured or Killed' SubClassOf 'CES Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132561</classIRI>
<classLabel>CES - See Someone Hit by Rounds</classLabel>
<newAxiom>'CES - See Someone Hit by Rounds' SubClassOf 'CES Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132564</classIRI>
<classLabel>EPDS - Looked Forward With Enjoyment</classLabel>
<newAxiom>'EPDS - Looked Forward With Enjoyment' SubClassOf 'EPDS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132563</classIRI>
<classLabel>EPDS - Able to Laugh and See Funny Side</classLabel>
<newAxiom>'EPDS - Able to Laugh and See Funny Side' SubClassOf 'EPDS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132566</classIRI>
<classLabel>EPDS - Anxious or Worried No Good Reason</classLabel>
<newAxiom>'EPDS - Anxious or Worried No Good Reason' SubClassOf 'EPDS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132565</classIRI>
<classLabel>EPDS - Blamed Myself Unnecessarily</classLabel>
<newAxiom>'EPDS - Blamed Myself Unnecessarily' SubClassOf 'EPDS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132568</classIRI>
<classLabel>EPDS - Things Getting on Top of Me</classLabel>
<newAxiom>'EPDS - Things Getting on Top of Me' SubClassOf 'EPDS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132567</classIRI>
<classLabel>EPDS - Scared or Panicky for No Good Reason</classLabel>
<newAxiom>'EPDS - Scared or Panicky for No Good Reason' SubClassOf 'EPDS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132571</classIRI>
<classLabel>EPDS - So Unhappy I Have Been Crying</classLabel>
<newAxiom>'EPDS - So Unhappy I Have Been Crying' SubClassOf 'EPDS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132570</classIRI>
<classLabel>EPDS - I Have Felt Sad or Miserable</classLabel>
<newAxiom>'EPDS - I Have Felt Sad or Miserable' SubClassOf 'EPDS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132515</classIRI>
<classLabel>Superior Mediastinal Lymph Node Group (Level VII)</classLabel>
<newAxiom>'Superior Mediastinal Lymph Node Group (Level VII)' SubClassOf 'Neck Lymph Node Groups'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132514</classIRI>
<classLabel>Anterior Compartment Lymph Node Group (Level VI)</classLabel>
<newAxiom>'Anterior Compartment Lymph Node Group (Level VI)' SubClassOf 'Neck Lymph Node Groups'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132517</classIRI>
<classLabel>CDISC Clinical Classification NSAA Test Code Terminology</classLabel>
<newAxiom>'CDISC Clinical Classification NSAA Test Code Terminology' SubClassOf 'CDISC Clinical Classification Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132516</classIRI>
<classLabel>CDISC Clinical Classification NSAA Test Name Terminology</classLabel>
<newAxiom>'CDISC Clinical Classification NSAA Test Name Terminology' SubClassOf 'CDISC Clinical Classification Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132519</classIRI>
<classLabel>CDISC Questionnaire CES Test Code Terminology</classLabel>
<newAxiom>'CDISC Questionnaire CES Test Code Terminology' SubClassOf 'CDISC Questionnaire Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132518</classIRI>
<classLabel>CDISC Questionnaire CES Test Name Terminology</classLabel>
<newAxiom>'CDISC Questionnaire CES Test Name Terminology' SubClassOf 'CDISC Questionnaire Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132511</classIRI>
<classLabel>Middle Jugular Lymph Node Group (Level III)</classLabel>
<newAxiom>'Middle Jugular Lymph Node Group (Level III)' SubClassOf 'Neck Lymph Node Groups'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132510</classIRI>
<classLabel>Upper Jugular Lymph Node Group (Sublevels IIA and IIB)</classLabel>
<newAxiom>'Upper Jugular Lymph Node Group (Sublevels IIA and IIB)' SubClassOf 'Neck Lymph Node Groups'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132513</classIRI>
<classLabel>Posterior Triangle Lymph Node Group (Sublevels VA and VB)</classLabel>
<newAxiom>'Posterior Triangle Lymph Node Group (Sublevels VA and VB)' SubClassOf 'Neck Lymph Node Groups'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132512</classIRI>
<classLabel>Lower Jugular Lymph Node Group (Level IV)</classLabel>
<newAxiom>'Lower Jugular Lymph Node Group (Level IV)' SubClassOf 'Neck Lymph Node Groups'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132504</classIRI>
<classLabel>Neck Lymph Node Boundary Level VII</classLabel>
<newAxiom>'Neck Lymph Node Boundary Level VII' SubClassOf 'Neck Lymph Node Boundary Levels and Sublevels'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132503</classIRI>
<classLabel>Neck Lymph Node Boundary Level VI</classLabel>
<newAxiom>'Neck Lymph Node Boundary Level VI' SubClassOf 'Neck Lymph Node Boundary Levels and Sublevels'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132506</classIRI>
<classLabel>Recurrent Glioma</classLabel>
<newAxiom>'Recurrent Glioma' EquivalentTo 'Glioma' and 'Recurrent Central Nervous System Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132505</classIRI>
<classLabel>Grade II Glioma</classLabel>
<newAxiom>'Grade II Glioma' EquivalentTo 'Low Grade Glioma' and ('Disease_Is_Grade' some 'Grade 2')</newAxiom>
</newClass>
<newClass>
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<classLabel>Submental Lymph Node Group (Sublevel IA)</classLabel>
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<classLabel>EPDS Questionnaire Question</classLabel>
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<classLabel>CES Questionnaire Question</classLabel>
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<classLabel>HAQ-DI Without VAS - Take a Tub Bath</classLabel>
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<newClass>
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<classLabel>HAQ-DI Without VAS - Aid: Crutches</classLabel>
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</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132603</classIRI>
<classLabel>HAQ-DI Without VAS - Run Errands and Shop</classLabel>
<newAxiom>'HAQ-DI Without VAS - Run Errands and Shop' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132602</classIRI>
<classLabel>HAQ-DI Without VAS - Turn Faucets On And Off</classLabel>
<newAxiom>'HAQ-DI Without VAS - Turn Faucets On And Off' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132605</classIRI>
<classLabel>HAQ-DI Without VAS - Able to Do Chores</classLabel>
<newAxiom>'HAQ-DI Without VAS - Able to Do Chores' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132604</classIRI>
<classLabel>HAQ-DI Without VAS - Get In and Out of a Car</classLabel>
<newAxiom>'HAQ-DI Without VAS - Get In and Out of a Car' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132607</classIRI>
<classLabel>HAQ-DI Without VAS - Aid: Bathtub Seat</classLabel>
<newAxiom>'HAQ-DI Without VAS - Aid: Bathtub Seat' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132606</classIRI>
<classLabel>HAQ-DI Without VAS - Aid: Raised Toilet Seat</classLabel>
<newAxiom>'HAQ-DI Without VAS - Aid: Raised Toilet Seat' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132609</classIRI>
<classLabel>HAQ-DI Without VAS - Aid: Bathtub Bar</classLabel>
<newAxiom>'HAQ-DI Without VAS - Aid: Bathtub Bar' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132608</classIRI>
<classLabel>HAQ-DI Without VAS - Aid: Jar Opener (Previously Open)</classLabel>
<newAxiom>'HAQ-DI Without VAS - Aid: Jar Opener (Previously Open)' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132601</classIRI>
<classLabel>HAQ-DI Without VAS - Open Jars Previously Opened</classLabel>
<newAxiom>'HAQ-DI Without VAS - Open Jars Previously Opened' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132600</classIRI>
<classLabel>HAQ-DI Without VAS - Open Car Doors</classLabel>
<newAxiom>'HAQ-DI Without VAS - Open Car Doors' SubClassOf 'HAQ-DI Without VAS Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132317</classIRI>
<classLabel>CDISC SDTM Genetic Region of Interest Type Terminology</classLabel>
<newAxiom>'CDISC SDTM Genetic Region of Interest Type Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132316</classIRI>
<classLabel>CDISC SDTM Ebola Virus Findings About Test Code Terminology</classLabel>
<newAxiom>'CDISC SDTM Ebola Virus Findings About Test Code Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132319</classIRI>
<classLabel>CDISC SDTM Malaria Findings About Test Name Terminology</classLabel>
<newAxiom>'CDISC SDTM Malaria Findings About Test Name Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132311</classIRI>
<classLabel>CDISC SDTM Administration Technique Response Terminology</classLabel>
<newAxiom>'CDISC SDTM Administration Technique Response Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132310</classIRI>
<classLabel>CDISC Protocol Entities Terminology</classLabel>
<newAxiom>'CDISC Protocol Entities Terminology' SubClassOf 'CDISC Protocol Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132313</classIRI>
<classLabel>CDISC SDTM Asthma Findings About Test Code Terminology</classLabel>
<newAxiom>'CDISC SDTM Asthma Findings About Test Code Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132312</classIRI>
<classLabel>CDISC SDTM Asthma Findings About Test Name Terminology</classLabel>
<newAxiom>'CDISC SDTM Asthma Findings About Test Name Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132315</classIRI>
<classLabel>CDISC SDTM Ebola Virus Findings About Test Name Terminology</classLabel>
<newAxiom>'CDISC SDTM Ebola Virus Findings About Test Name Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132314</classIRI>
<classLabel>CDISC SDTM Specimen Collection Method Terminology</classLabel>
<newAxiom>'CDISC SDTM Specimen Collection Method Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132306</classIRI>
<classLabel>Healthcare Financing Administration Common Procedure Coding System</classLabel>
<newAxiom>'Healthcare Financing Administration Common Procedure Coding System' SubClassOf 'Code'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132305</classIRI>
<classLabel>Office of Management and Budget</classLabel>
<newAxiom>'Office of Management and Budget' SubClassOf 'Professional Organization or Group'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132308</classIRI>
<classLabel>CDISC Protocol Entities Physical Address Attribute Terminology</classLabel>
<newAxiom>'CDISC Protocol Entities Physical Address Attribute Terminology' SubClassOf 'CDISC Protocol Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132307</classIRI>
<classLabel>ICD-10 Procedure Coding System</classLabel>
<newAxiom>'ICD-10 Procedure Coding System' SubClassOf 'Code'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132309</classIRI>
<classLabel>CDISC Protocol Entities Study Protocol Attribute Terminology</classLabel>
<newAxiom>'CDISC Protocol Entities Study Protocol Attribute Terminology' SubClassOf 'CDISC Protocol Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132300</classIRI>
<classLabel>Protocol Title</classLabel>
<newAxiom>'Protocol Title' SubClassOf 'Title'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132302</classIRI>
<classLabel>Average Concentration from T1 to T2</classLabel>
<newAxiom>'Average Concentration from T1 to T2' SubClassOf 'Average Concentration'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132301</classIRI>
<classLabel>Ribonucleic Acid Measurement</classLabel>
<newAxiom>'Ribonucleic Acid Measurement' SubClassOf 'Chemistry Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132304</classIRI>
<classLabel>Rater</classLabel>
<newAxiom>'Rater' SubClassOf 'Research Personnel'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132303</classIRI>
<classLabel>Microscopist</classLabel>
<newAxiom>'Microscopist' SubClassOf 'Research Personnel'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132339</classIRI>
<classLabel>Anti-LAG-3 Monoclonal Antibody REGN3767</classLabel>
<newAxiom>'Anti-LAG-3 Monoclonal Antibody REGN3767' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132338</classIRI>
<classLabel>Oncogene TIM Protein</classLabel>
<newAxiom>'Oncogene TIM Protein' SubClassOf 'Gene_Product_Has_Structural_Domain_Or_Motif' some 'PH Domain'</newAxiom>
<newAxiom>'Oncogene TIM Protein' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'Oncogene TIM Protein' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'ARHGEF5 Gene'</newAxiom>
<newAxiom>'Oncogene TIM Protein' SubClassOf 'ARHGEF5 Gene Product'</newAxiom>
<newAxiom>'Oncogene TIM Protein' SubClassOf 'Gene_Product_Has_Structural_Domain_Or_Motif' some 'SH3 Domain'</newAxiom>
<newAxiom>'Oncogene TIM Protein' SubClassOf 'Gene_Product_Has_Structural_Domain_Or_Motif' some 'DH Domain'</newAxiom>
<newAxiom>'Oncogene TIM Protein' SubClassOf 'Gene_Product_Has_Organism_Source' some 'Human'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132331</classIRI>
<classLabel>Human Cytomegalovirus Envelope Glycoprotein B</classLabel>
<newAxiom>'Human Cytomegalovirus Envelope Glycoprotein B' SubClassOf 'Viral Protein'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132330</classIRI>
<classLabel>B-Cell CLL/Lymphoma 9-Like Protein</classLabel>
<newAxiom>'B-Cell CLL/Lymphoma 9-Like Protein' EquivalentTo 'Transcription Regulatory Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleus') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Proline-Rich Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Transcription Coactivator') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Activation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Epithelial-to-Mesenchymal Transition') and ('Gene_Product_Encoded_By_Gene' some 'BCL9L Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132333</classIRI>
<classLabel>Approved Drug Product Manufactured Under Contract</classLabel>
<newAxiom>'Approved Drug Product Manufactured Under Contract' SubClassOf 'Structured Product Labeling Marketing Category'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132332</classIRI>
<classLabel>Extravascular Extracellular Volume Fraction</classLabel>
<newAxiom>'Extravascular Extracellular Volume Fraction' SubClassOf 'Cardiovascular System Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132335</classIRI>
<classLabel>Unapproved Drug Product Manufactured Under Contract</classLabel>
<newAxiom>'Unapproved Drug Product Manufactured Under Contract' SubClassOf 'Structured Product Labeling Marketing Category'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132334</classIRI>
<classLabel>OTC Monograph Drug Product Manufactured Under Contract</classLabel>
<newAxiom>'OTC Monograph Drug Product Manufactured Under Contract' SubClassOf 'Structured Product Labeling Marketing Category'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132337</classIRI>
<classLabel>ARHGEF5 Gene Product</classLabel>
<newAxiom>'ARHGEF5 Gene Product' SubClassOf 'Guanine Nucleotide Exchange Factor'</newAxiom>
<newAxiom>'ARHGEF5 Gene Product' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'ARHGEF5 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132336</classIRI>
<classLabel>Guideline Concordant Care</classLabel>
<newAxiom>'Guideline Concordant Care' SubClassOf 'Patient Care'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132340</classIRI>
<classLabel>Best Observed Case Imputation Technique</classLabel>
<newAxiom>'Best Observed Case Imputation Technique' SubClassOf 'Statistical Imputation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132328</classIRI>
<classLabel>BCL9L Gene</classLabel>
<newAxiom>'BCL9L Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Activation'</newAxiom>
<newAxiom>'BCL9L Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Epithelial-to-Mesenchymal Transition'</newAxiom>
<newAxiom>'BCL9L Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'BCL9L Gene' SubClassOf 'Transcription Regulation Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132327</classIRI>
<classLabel>Phosphoglycerate Mutase 1</classLabel>
<newAxiom>'Phosphoglycerate Mutase 1' EquivalentTo 'Isomerase' and ('Gene_Product_Is_Element_In_Pathway' some 'Glycine, Serine and Threonine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Glycolysis/Gluconeogenesis Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Glycolysis Pathway') and ('Gene_Product_Expressed_In_Tissue' some 'Brain') and ('Gene_Product_Expressed_In_Tissue' some 'Hepatic Tissue') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Proline-Rich Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Phosphoglycerate Mutase Family') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Gluconeogenic Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Glycolysis') and ('Gene_Product_Encoded_By_Gene' some 'PGAM1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132329</classIRI>
<classLabel>BCL9L wt Allele</classLabel>
<newAxiom>'BCL9L wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '11q23.3'</newAxiom>
<newAxiom>'BCL9L wt Allele' SubClassOf 'BCL9L Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132320</classIRI>
<classLabel>CDISC SDTM Malaria Findings About Test Code Terminology</classLabel>
<newAxiom>'CDISC SDTM Malaria Findings About Test Code Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132322</classIRI>
<classLabel>RHBDF2 Gene</classLabel>
<newAxiom>'RHBDF2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Receptor Signaling'</newAxiom>
<newAxiom>'RHBDF2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Protein Secretion'</newAxiom>
<newAxiom>'RHBDF2 Gene' SubClassOf 'Regulatory Gene'</newAxiom>
<newAxiom>'RHBDF2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Intercellular Communication Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132321</classIRI>
<classLabel>CDISC SEND Within Normal Limits Results Terminology</classLabel>
<newAxiom>'CDISC SEND Within Normal Limits Results Terminology' SubClassOf 'CDISC SEND Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132324</classIRI>
<classLabel>Inactive Rhomboid Protein 2</classLabel>
<newAxiom>'Inactive Rhomboid Protein 2' EquivalentTo 'Regulatory Protein' and ('Gene_Product_Has_Chemical_Classification' some 'Transmembrane Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Membrane of the Rough Endoplasmic Reticulum') and ('Gene_Product_Has_Associated_Anatomy' some 'Membrane of the Smooth Endoplasmic Reticulum') and ('Gene_Product_Expressed_In_Tissue' some 'Epidermis') and ('Gene_Product_Expressed_In_Tissue' some 'Esophageal Epithelium') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Transmembrane Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Protease Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Intercellular Communication Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Protein Secretion') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Receptor Signaling') and ('Gene_Product_Encoded_By_Gene' some 'RHBDF2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132323</classIRI>
<classLabel>RHBDF2 wt Allele</classLabel>
<newAxiom>'RHBDF2 wt Allele' SubClassOf 'RHBDF2 Gene'</newAxiom>
<newAxiom>'RHBDF2 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '17q25.3'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132326</classIRI>
<classLabel>PGAM1 wt Allele</classLabel>
<newAxiom>'PGAM1 wt Allele' EquivalentTo 'PGAM1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Glycine, Serine and Threonine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Glycolysis/Gluconeogenesis Pathway') and ('Gene_Is_Element_In_Pathway' some 'Glycolysis Pathway') and ('Gene_In_Chromosomal_Location' some '10q24.1')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132325</classIRI>
<classLabel>PGAM1 Gene</classLabel>
<newAxiom>'PGAM1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Glycolysis'</newAxiom>
<newAxiom>'PGAM1 Gene' SubClassOf 'Isomerase Gene'</newAxiom>
<newAxiom>'PGAM1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Gluconeogenic Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132397</classIRI>
<classLabel>Left Lung, Inferior Lobe, Superior Segment</classLabel>
<newAxiom>'Left Lung, Inferior Lobe, Superior Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132396</classIRI>
<classLabel>Left Lung, Inferior Lobe, Posterior Basal Segment</classLabel>
<newAxiom>'Left Lung, Inferior Lobe, Posterior Basal Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132399</classIRI>
<classLabel>Left Lung, Superior Lobe, Apicoposterior Segment</classLabel>
<newAxiom>'Left Lung, Superior Lobe, Apicoposterior Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132398</classIRI>
<classLabel>Left Lung, Superior Lobe, Anterior Segment</classLabel>
<newAxiom>'Left Lung, Superior Lobe, Anterior Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132386</classIRI>
<classLabel>Soluble Intercellular Adhesion Molecule 1 Measurement</classLabel>
<newAxiom>'Soluble Intercellular Adhesion Molecule 1 Measurement' SubClassOf 'Protein or Enzyme Type Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132385</classIRI>
<classLabel>Prostate Specific Antigen mRNA Measurement</classLabel>
<newAxiom>'Prostate Specific Antigen mRNA Measurement' SubClassOf 'Prostate Specific Antigen Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132388</classIRI>
<classLabel>Treponema pallidum Antibody Measurement</classLabel>
<newAxiom>'Treponema pallidum Antibody Measurement' SubClassOf 'Immunology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132387</classIRI>
<classLabel>T-Kininogen Measurement</classLabel>
<newAxiom>'T-Kininogen Measurement' SubClassOf 'Protein or Enzyme Type Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132389</classIRI>
<classLabel>Vascular Endothelial Growth Factor A Measurement</classLabel>
<newAxiom>'Vascular Endothelial Growth Factor A Measurement' SubClassOf 'Protein or Enzyme Type Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132391</classIRI>
<classLabel>Diaphragmatic Lymph Node</classLabel>
<newAxiom>'Diaphragmatic Lymph Node' SubClassOf 'Lymph Node by Anatomic Site'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132390</classIRI>
<classLabel>Periventricular Region</classLabel>
<newAxiom>'Periventricular Region' SubClassOf 'Body Region'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132393</classIRI>
<classLabel>Left Lung, Inferior Lobe, Anterior Basal Segment</classLabel>
<newAxiom>'Left Lung, Inferior Lobe, Anterior Basal Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132392</classIRI>
<classLabel>Inferior Pubic Ramus</classLabel>
<newAxiom>'Inferior Pubic Ramus' SubClassOf 'Pubic Bone'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132395</classIRI>
<classLabel>Left Lung, Inferior Lobe, Medial Basal Segment</classLabel>
<newAxiom>'Left Lung, Inferior Lobe, Medial Basal Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132394</classIRI>
<classLabel>Left Lung, Inferior Lobe, Lateral Basal Segment</classLabel>
<newAxiom>'Left Lung, Inferior Lobe, Lateral Basal Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132353</classIRI>
<classLabel>Induced Expectoration Technique</classLabel>
<newAxiom>'Induced Expectoration Technique' SubClassOf 'Diagnostic Procedure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132352</classIRI>
<classLabel>Protocol Approval Date</classLabel>
<newAxiom>'Protocol Approval Date' SubClassOf 'Approval Date'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132355</classIRI>
<classLabel>6 Lead NEHB-SPORI</classLabel>
<newAxiom>'6 Lead NEHB-SPORI' SubClassOf 'Lead Placement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132354</classIRI>
<classLabel>Associated Persons Demographics Submission Domain</classLabel>
<newAxiom>'Associated Persons Demographics Submission Domain' SubClassOf 'Submission Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132357</classIRI>
<classLabel>CDISC Integrated Basic Data Structure Dataset</classLabel>
<newAxiom>'CDISC Integrated Basic Data Structure Dataset' SubClassOf 'Data Set'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132356</classIRI>
<classLabel>8 Lead Standard</classLabel>
<newAxiom>'8 Lead Standard' SubClassOf 'Lead Placement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132359</classIRI>
<classLabel>CDISC Integrated Subject Level Dataset</classLabel>
<newAxiom>'CDISC Integrated Subject Level Dataset' SubClassOf 'Data Set'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132358</classIRI>
<classLabel>CDISC Integrated Occurrence Data Structure Dataset</classLabel>
<newAxiom>'CDISC Integrated Occurrence Data Structure Dataset' SubClassOf 'Data Set'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132360</classIRI>
<classLabel>Ebola Virus Specific IgG Antibody Secreting Cell Count</classLabel>
<newAxiom>'Ebola Virus Specific IgG Antibody Secreting Cell Count' SubClassOf 'Cell Count'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132362</classIRI>
<classLabel>IgM Antibody Secreting Cell Count</classLabel>
<newAxiom>'IgM Antibody Secreting Cell Count' SubClassOf 'Cell Count'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132361</classIRI>
<classLabel>Ebola Virus Specific IgM Antibody Secreting Cell Count</classLabel>
<newAxiom>'Ebola Virus Specific IgM Antibody Secreting Cell Count' SubClassOf 'Cell Count'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132349</classIRI>
<classLabel>Schedule of Activities</classLabel>
<newAxiom>'Schedule of Activities' SubClassOf 'Schedule'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132342</classIRI>
<classLabel>Last Value Prior to Dosing Imputation Technique</classLabel>
<newAxiom>'Last Value Prior to Dosing Imputation Technique' SubClassOf 'Statistical Imputation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132341</classIRI>
<classLabel>Last Observed Value Imputation Technique</classLabel>
<newAxiom>'Last Observed Value Imputation Technique' SubClassOf 'Statistical Imputation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132344</classIRI>
<classLabel>Alternate Protocol Identifier</classLabel>
<newAxiom>'Alternate Protocol Identifier' SubClassOf 'Protocol Identifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132343</classIRI>
<classLabel>Worst Observed Case Imputation Technique</classLabel>
<newAxiom>'Worst Observed Case Imputation Technique' SubClassOf 'Statistical Imputation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132346</classIRI>
<classLabel>Official Protocol Title</classLabel>
<newAxiom>'Official Protocol Title' SubClassOf 'Protocol Title'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132345</classIRI>
<classLabel>Brief Protocol Title</classLabel>
<newAxiom>'Brief Protocol Title' SubClassOf 'Protocol Title'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132348</classIRI>
<classLabel>Registry Protocol Identifier</classLabel>
<newAxiom>'Registry Protocol Identifier' SubClassOf 'Protocol Identifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132347</classIRI>
<classLabel>Protocol Amendment</classLabel>
<newAxiom>'Protocol Amendment' SubClassOf 'Amendment'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132351</classIRI>
<classLabel>Sponsor Protocol Identifier</classLabel>
<newAxiom>'Sponsor Protocol Identifier' SubClassOf 'Protocol Identifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132350</classIRI>
<classLabel>Scientific Protocol Title</classLabel>
<newAxiom>'Scientific Protocol Title' SubClassOf 'Protocol Title'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132375</classIRI>
<classLabel>Lymphotoxin Alpha Measurement</classLabel>
<newAxiom>'Lymphotoxin Alpha Measurement' SubClassOf 'Protein or Enzyme Type Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132374</classIRI>
<classLabel>Kallikrein-2 Measurement</classLabel>
<newAxiom>'Kallikrein-2 Measurement' SubClassOf 'Protein or Enzyme Type Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132377</classIRI>
<classLabel>Oncostatin M Measurement</classLabel>
<newAxiom>'Oncostatin M Measurement' SubClassOf 'Protein or Enzyme Type Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132376</classIRI>
<classLabel>Neutrophilic Toxic Change Assessment</classLabel>
<newAxiom>'Neutrophilic Toxic Change Assessment' SubClassOf 'Immunology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132379</classIRI>
<classLabel>Prostate Cancer Antigen 3 mRNA Measurement</classLabel>
<newAxiom>'Prostate Cancer Antigen 3 mRNA Measurement' SubClassOf 'Ribonucleic Acid Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132378</classIRI>
<classLabel>PCA3 mRNA to PSA mRNA Ratio Measurement</classLabel>
<newAxiom>'PCA3 mRNA to PSA mRNA Ratio Measurement' SubClassOf 'Ribonucleic Acid Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132380</classIRI>
<classLabel>Platelet Mass Distribution Width</classLabel>
<newAxiom>'Platelet Mass Distribution Width' SubClassOf 'Hematology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132382</classIRI>
<classLabel>Circulating Prostate Tumor Cell Count</classLabel>
<newAxiom>'Circulating Prostate Tumor Cell Count' SubClassOf 'Circulating Tumor Cell Count'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132381</classIRI>
<classLabel>Calculated Panel Reactive Antibody Measurement</classLabel>
<newAxiom>'Calculated Panel Reactive Antibody Measurement' SubClassOf 'Immunology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132384</classIRI>
<classLabel>Free PSA to Total PSA Ratio Measurement</classLabel>
<newAxiom>'Free PSA to Total PSA Ratio Measurement' SubClassOf 'Prostate Specific Antigen Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132383</classIRI>
<classLabel>Free Prostate Specific Antigen Measurement</classLabel>
<newAxiom>'Free Prostate Specific Antigen Measurement' SubClassOf 'Prostate Specific Antigen Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132364</classIRI>
<classLabel>Alpha-Methylacyl Coenzyme A Racemase Measurement</classLabel>
<newAxiom>'Alpha-Methylacyl Coenzyme A Racemase Measurement' SubClassOf 'Protein or Enzyme Type Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132363</classIRI>
<classLabel>High Molecular Weight Adiponectin Measurement</classLabel>
<newAxiom>'High Molecular Weight Adiponectin Measurement' SubClassOf 'Protein or Enzyme Type Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132366</classIRI>
<classLabel>Squamous Epithelial Cells to Total Cells Ratio Measurement</classLabel>
<newAxiom>'Squamous Epithelial Cells to Total Cells Ratio Measurement' SubClassOf 'Cell Count'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132365</classIRI>
<classLabel>Alpha-Methylacyl Coenzyme A Racemase mRNA Measurement</classLabel>
<newAxiom>'Alpha-Methylacyl Coenzyme A Racemase mRNA Measurement' SubClassOf 'Ribonucleic Acid Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132368</classIRI>
<classLabel>G6PD-Deficient Erythrocytes Count</classLabel>
<newAxiom>'G6PD-Deficient Erythrocytes Count' SubClassOf 'Cell Count'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132367</classIRI>
<classLabel>Folate Hydrolase mRNA Measurement</classLabel>
<newAxiom>'Folate Hydrolase mRNA Measurement' SubClassOf 'Ribonucleic Acid Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132369</classIRI>
<classLabel>G6PD-Deficient Erythrocytes to Erythrocytes Ratio Measurement</classLabel>
<newAxiom>'G6PD-Deficient Erythrocytes to Erythrocytes Ratio Measurement' SubClassOf 'Cell Count'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132371</classIRI>
<classLabel>Glycerol Measurement</classLabel>
<newAxiom>'Glycerol Measurement' SubClassOf 'Chemistry Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132370</classIRI>
<classLabel>1,3-Beta-D-Glucan Measurement</classLabel>
<newAxiom>'1,3-Beta-D-Glucan Measurement' SubClassOf 'Immunology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132373</classIRI>
<classLabel>Keyhole Limpet Hemocyanin IgM Antibody Measurement</classLabel>
<newAxiom>'Keyhole Limpet Hemocyanin IgM Antibody Measurement' SubClassOf 'Immunology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132372</classIRI>
<classLabel>Keyhole Limpet Hemocyanin IgG Antibody Measurement</classLabel>
<newAxiom>'Keyhole Limpet Hemocyanin IgG Antibody Measurement' SubClassOf 'Immunology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132438</classIRI>
<classLabel>Accumulation Ratio Cmin Normalized by Dose</classLabel>
<newAxiom>'Accumulation Ratio Cmin Normalized by Dose' SubClassOf 'Accumulation Ratio Cmin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132437</classIRI>
<classLabel>Accumulation Ratio Cmax Normalized by Dose</classLabel>
<newAxiom>'Accumulation Ratio Cmax Normalized by Dose' SubClassOf 'Accumulation Ratio Cmax'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132439</classIRI>
<classLabel>Accumulation Ratio Ctrough Normalized by Dose</classLabel>
<newAxiom>'Accumulation Ratio Ctrough Normalized by Dose' SubClassOf 'Accumulation Ratio Ctrough'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132430</classIRI>
<classLabel>Cellular Differentiation Assessment</classLabel>
<newAxiom>'Cellular Differentiation Assessment' SubClassOf 'Histologic Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132432</classIRI>
<classLabel>Hyperemia Grade</classLabel>
<newAxiom>'Hyperemia Grade' SubClassOf 'Disease Grade Qualifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132431</classIRI>
<classLabel>Folate Hydrolase 1 Measurement</classLabel>
<newAxiom>'Folate Hydrolase 1 Measurement' SubClassOf 'Protein or Enzyme Type Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132434</classIRI>
<classLabel>Amplicon Size</classLabel>
<newAxiom>'Amplicon Size' SubClassOf 'Size'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132433</classIRI>
<classLabel>Allelic Family</classLabel>
<newAxiom>'Allelic Family' SubClassOf 'Miscellaneous Molecular Biology Terms'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132436</classIRI>
<classLabel>Accumulation Ratio AUC T1 to T2 Normalized by Dose</classLabel>
<newAxiom>'Accumulation Ratio AUC T1 to T2 Normalized by Dose' SubClassOf 'Accumulation Ratio Area Under the Curve'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132435</classIRI>
<classLabel>Accumulation Ratio AUC Over Dosing Interval Normalized by Dose</classLabel>
<newAxiom>'Accumulation Ratio AUC Over Dosing Interval Normalized by Dose' SubClassOf 'Accumulation Ratio Area Under the Curve'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132427</classIRI>
<classLabel>Fluorescent Spot Test</classLabel>
<newAxiom>'Fluorescent Spot Test' SubClassOf 'Bioassay'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132426</classIRI>
<classLabel>Rater 2</classLabel>
<newAxiom>'Rater 2' SubClassOf 'Rater'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132429</classIRI>
<classLabel>Enhanced Liver Fibrosis Score</classLabel>
<newAxiom>'Enhanced Liver Fibrosis Score' SubClassOf 'Disease Grade Qualifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132428</classIRI>
<classLabel>Hillmen Color Chart</classLabel>
<newAxiom>'Hillmen Color Chart' SubClassOf 'Eye Examination'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132421</classIRI>
<classLabel>Microscopist 1</classLabel>
<newAxiom>'Microscopist 1' SubClassOf 'Microscopist'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132420</classIRI>
<classLabel>Zaire Ebolavirus Measurement</classLabel>
<newAxiom>'Zaire Ebolavirus Measurement' SubClassOf 'Microbiology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132423</classIRI>
<classLabel>Microscopist 3</classLabel>
<newAxiom>'Microscopist 3' SubClassOf 'Microscopist'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132422</classIRI>
<classLabel>Microscopist 2</classLabel>
<newAxiom>'Microscopist 2' SubClassOf 'Microscopist'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132425</classIRI>
<classLabel>Rater 1</classLabel>
<newAxiom>'Rater 1' SubClassOf 'Rater'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132424</classIRI>
<classLabel>Optometrist</classLabel>
<newAxiom>'Optometrist' SubClassOf 'Medical Occupation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132459</classIRI>
<classLabel>Primary Language Spoken</classLabel>
<newAxiom>'Primary Language Spoken' SubClassOf 'Property or Attribute'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132452</classIRI>
<classLabel>Suspected Source Case</classLabel>
<newAxiom>'Suspected Source Case' SubClassOf 'Person'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132451</classIRI>
<classLabel>Biological Relative, Paternal</classLabel>
<newAxiom>'Biological Relative, Paternal' SubClassOf 'Biological Relative'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132454</classIRI>
<classLabel>PCWG Scher Prostate Cancer 2016 Oncology Response Criteria</classLabel>
<newAxiom>'PCWG Scher Prostate Cancer 2016 Oncology Response Criteria' SubClassOf 'Tumor Response Criterion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132453</classIRI>
<classLabel>Forced Expiratory Volume in 3 Seconds</classLabel>
<newAxiom>'Forced Expiratory Volume in 3 Seconds' SubClassOf 'Pulmonary Function Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132456</classIRI>
<classLabel>Metastatic Disease Indicator</classLabel>
<newAxiom>'Metastatic Disease Indicator' SubClassOf 'Indicator'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132455</classIRI>
<classLabel>Bone Response</classLabel>
<newAxiom>'Bone Response' SubClassOf 'Disease Response'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132458</classIRI>
<classLabel>Tumor Marker Response</classLabel>
<newAxiom>'Tumor Marker Response' SubClassOf 'Disease Response'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132457</classIRI>
<classLabel>Soft Tissue Response</classLabel>
<newAxiom>'Soft Tissue Response' SubClassOf 'Disease Response'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132461</classIRI>
<classLabel>Capillary Plasma</classLabel>
<newAxiom>'Capillary Plasma' SubClassOf 'Plasma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132460</classIRI>
<classLabel>Secondary Language Spoken</classLabel>
<newAxiom>'Secondary Language Spoken' SubClassOf 'Property or Attribute'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132449</classIRI>
<classLabel>Household Member</classLabel>
<newAxiom>'Household Member' SubClassOf 'Member'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132448</classIRI>
<classLabel>Blood Donor</classLabel>
<newAxiom>'Blood Donor' SubClassOf 'Tissue Donor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132441</classIRI>
<classLabel>Average Concentration from T1 to T2 Normalized by Dose</classLabel>
<newAxiom>'Average Concentration from T1 to T2 Normalized by Dose' SubClassOf 'Average Concentration from T1 to T2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132440</classIRI>
<classLabel>Average Concentration from T1 to T2 Normalized by Body Mass Index</classLabel>
<newAxiom>'Average Concentration from T1 to T2 Normalized by Body Mass Index' SubClassOf 'Average Concentration from T1 to T2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132443</classIRI>
<classLabel>Average Concentration from T1 to T2 Normalized by Weight</classLabel>
<newAxiom>'Average Concentration from T1 to T2 Normalized by Weight' SubClassOf 'Average Concentration from T1 to T2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132442</classIRI>
<classLabel>Average Concentration from T1 to T2 Normalized by Surface Area</classLabel>
<newAxiom>'Average Concentration from T1 to T2 Normalized by Surface Area' SubClassOf 'Average Concentration from T1 to T2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132445</classIRI>
<classLabel>Hour Times Nanomole per Liter per Milligram per Kilogram</classLabel>
<newAxiom>'Hour Times Nanomole per Liter per Milligram per Kilogram' SubClassOf 'Measurement Unit Description'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132444</classIRI>
<classLabel>Day Times Microgram per Milliliter Times Kilogram per Milligram</classLabel>
<newAxiom>'Day Times Microgram per Milliliter Times Kilogram per Milligram' SubClassOf 'Measurement Unit Description'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132447</classIRI>
<classLabel>Eligibility Criteria Met By Subject</classLabel>
<newAxiom>'Eligibility Criteria Met By Subject' SubClassOf 'Property or Attribute'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132446</classIRI>
<classLabel>Hour Times Micromole per Liter per Milligram per Kilogram</classLabel>
<newAxiom>'Hour Times Micromole per Liter per Milligram per Kilogram' SubClassOf 'Measurement Unit Description'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132450</classIRI>
<classLabel>Stepmother</classLabel>
<newAxiom>'Stepmother' SubClassOf 'Step Relative'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132416</classIRI>
<classLabel>Microoganism Detection</classLabel>
<newAxiom>'Microoganism Detection' SubClassOf 'Microbiology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132415</classIRI>
<classLabel>Superior Pubic Ramus</classLabel>
<newAxiom>'Superior Pubic Ramus' SubClassOf 'Pubic Bone'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132418</classIRI>
<classLabel>Sexual Plasmodium knowlesi Measurement</classLabel>
<newAxiom>'Sexual Plasmodium knowlesi Measurement' SubClassOf 'Microbiology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132417</classIRI>
<classLabel>Asexual Plasmodium knowlesi Measurement</classLabel>
<newAxiom>'Asexual Plasmodium knowlesi Measurement' SubClassOf 'Microbiology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132419</classIRI>
<classLabel>Taxonomic Identification Below Species Level</classLabel>
<newAxiom>'Taxonomic Identification Below Species Level' SubClassOf 'Microbiology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132410</classIRI>
<classLabel>Right Lung, Superior Lobe, Apical Segment</classLabel>
<newAxiom>'Right Lung, Superior Lobe, Apical Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132412</classIRI>
<classLabel>Periureteral Region</classLabel>
<newAxiom>'Periureteral Region' SubClassOf 'Body Region'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132411</classIRI>
<classLabel>Right Lung, Superior Lobe, Posterior Segment</classLabel>
<newAxiom>'Right Lung, Superior Lobe, Posterior Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132414</classIRI>
<classLabel>Presacral Space</classLabel>
<newAxiom>'Presacral Space' SubClassOf 'Body Region'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132413</classIRI>
<classLabel>Portal Vein Bifurcation</classLabel>
<newAxiom>'Portal Vein Bifurcation' SubClassOf 'Venous Segment'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132405</classIRI>
<classLabel>Right Lung, Inferior Lobe, Posterior Basal Segment</classLabel>
<newAxiom>'Right Lung, Inferior Lobe, Posterior Basal Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132404</classIRI>
<classLabel>Right Lung, Inferior Lobe, Medial Basal Segment</classLabel>
<newAxiom>'Right Lung, Inferior Lobe, Medial Basal Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132407</classIRI>
<classLabel>Right Lung, Middle Lobe, Lateral Segment</classLabel>
<newAxiom>'Right Lung, Middle Lobe, Lateral Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132406</classIRI>
<classLabel>Right Lung, Inferior Lobe, Superior Segment</classLabel>
<newAxiom>'Right Lung, Inferior Lobe, Superior Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132409</classIRI>
<classLabel>Right Lung, Superior Lobe, Anterior Segment</classLabel>
<newAxiom>'Right Lung, Superior Lobe, Anterior Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132408</classIRI>
<classLabel>Right Lung, Middle Lobe, Medial Segment</classLabel>
<newAxiom>'Right Lung, Middle Lobe, Medial Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132401</classIRI>
<classLabel>Left Lung, Superior Lobe, Superior Lingular Segment</classLabel>
<newAxiom>'Left Lung, Superior Lobe, Superior Lingular Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132400</classIRI>
<classLabel>Left Lung, Superior Lobe, Inferior Lingular Segment</classLabel>
<newAxiom>'Left Lung, Superior Lobe, Inferior Lingular Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132403</classIRI>
<classLabel>Right Lung, Inferior Lobe, Lateral Basal Segment</classLabel>
<newAxiom>'Right Lung, Inferior Lobe, Lateral Basal Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132402</classIRI>
<classLabel>Right Lung, Inferior Lobe, Anterior Basal Segment</classLabel>
<newAxiom>'Right Lung, Inferior Lobe, Anterior Basal Segment' SubClassOf 'Respiratory System Part'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132474</classIRI>
<classLabel>Per 2500 White Blood Cells</classLabel>
<newAxiom>'Per 2500 White Blood Cells' SubClassOf 'Miscellaneous Fraction Unit'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132473</classIRI>
<classLabel>Per 2000 Red Blood Cells</classLabel>
<newAxiom>'Per 2000 Red Blood Cells' SubClassOf 'Miscellaneous Fraction Unit'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132476</classIRI>
<classLabel>Per 500 White Blood Cells</classLabel>
<newAxiom>'Per 500 White Blood Cells' SubClassOf 'Miscellaneous Fraction Unit'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132475</classIRI>
<classLabel>Per 40 High Powered Fields</classLabel>
<newAxiom>'Per 40 High Powered Fields' SubClassOf 'Per Visual Field'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132478</classIRI>
<classLabel>Log10 50 Percent Tissue Culture Infective Dose per Milliliter</classLabel>
<newAxiom>'Log10 50 Percent Tissue Culture Infective Dose per Milliliter' SubClassOf 'Unit of Arbitrary Substance Concentration'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132477</classIRI>
<classLabel>Base Pair Unit</classLabel>
<newAxiom>'Base Pair Unit' SubClassOf 'Miscellaneous Unit'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132479</classIRI>
<classLabel>Log10 50 Percent Tissue Culture Infective Dose per Microliter</classLabel>
<newAxiom>'Log10 50 Percent Tissue Culture Infective Dose per Microliter' SubClassOf 'Unit of Arbitrary Substance Concentration'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132481</classIRI>
<classLabel>Microliter per Kilogram per Day</classLabel>
<newAxiom>'Microliter per Kilogram per Day' SubClassOf 'Unit of Dose Calculation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132480</classIRI>
<classLabel>MilliMerck Unit per Milliliter</classLabel>
<newAxiom>'MilliMerck Unit per Milliliter' SubClassOf 'Unit of Concentration'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132483</classIRI>
<classLabel>Adipocyte Accumulation</classLabel>
<newAxiom>'Adipocyte Accumulation' SubClassOf 'Morphologic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132482</classIRI>
<classLabel>Estimated Body Weight</classLabel>
<newAxiom>'Estimated Body Weight' SubClassOf 'Body Weight'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132463</classIRI>
<classLabel>Number of Bone Lesions</classLabel>
<newAxiom>'Number of Bone Lesions' SubClassOf 'Number'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132462</classIRI>
<classLabel>Venous Plasma</classLabel>
<newAxiom>'Venous Plasma' SubClassOf 'Plasma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132465</classIRI>
<classLabel>Two or More Persisting New Bone Lesions Indicator</classLabel>
<newAxiom>'Two or More Persisting New Bone Lesions Indicator' SubClassOf 'Indicator'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132464</classIRI>
<classLabel>Number of New Bone Lesions</classLabel>
<newAxiom>'Number of New Bone Lesions' SubClassOf 'Number'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132467</classIRI>
<classLabel>New Bone Lesion Lesion Identification</classLabel>
<newAxiom>'New Bone Lesion Lesion Identification' SubClassOf 'Lesion Identification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132466</classIRI>
<classLabel>Bone Lesion Identification</classLabel>
<newAxiom>'Bone Lesion Identification' SubClassOf 'Lesion Identification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132469</classIRI>
<classLabel>Non-Target Extra Nodal Lesion Identification</classLabel>
<newAxiom>'Non-Target Extra Nodal Lesion Identification' SubClassOf 'Lesion Identification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132468</classIRI>
<classLabel>Non-target Enhancing Lesion Identification</classLabel>
<newAxiom>'Non-target Enhancing Lesion Identification' SubClassOf 'Lesion Identification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132470</classIRI>
<classLabel>Non-Target Nodal Lesion Identification</classLabel>
<newAxiom>'Non-Target Nodal Lesion Identification' SubClassOf 'Lesion Identification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132472</classIRI>
<classLabel>Per 200 High Powered Fields</classLabel>
<newAxiom>'Per 200 High Powered Fields' SubClassOf 'Per Visual Field'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132471</classIRI>
<classLabel>Non-target Non-enhancing Lesion Identification</classLabel>
<newAxiom>'Non-target Non-enhancing Lesion Identification' SubClassOf 'Lesion Identification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132496</classIRI>
<classLabel>Neck Lymph Node Boundary Sublevel IB</classLabel>
<newAxiom>'Neck Lymph Node Boundary Sublevel IB' SubClassOf 'Neck Lymph Node Boundary Levels and Sublevels'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132495</classIRI>
<classLabel>Neck Lymph Node Boundary Sublevel IA</classLabel>
<newAxiom>'Neck Lymph Node Boundary Sublevel IA' SubClassOf 'Neck Lymph Node Boundary Levels and Sublevels'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132498</classIRI>
<classLabel>Neck Lymph Node Boundary Sublevel IIB</classLabel>
<newAxiom>'Neck Lymph Node Boundary Sublevel IIB' SubClassOf 'Neck Lymph Node Boundary Levels and Sublevels'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132497</classIRI>
<classLabel>Neck Lymph Node Boundary Sublevel IIA</classLabel>
<newAxiom>'Neck Lymph Node Boundary Sublevel IIA' SubClassOf 'Neck Lymph Node Boundary Levels and Sublevels'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132499</classIRI>
<classLabel>Neck Lymph Node Boundary Level III</classLabel>
<newAxiom>'Neck Lymph Node Boundary Level III' SubClassOf 'Neck Lymph Node Boundary Levels and Sublevels'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132485</classIRI>
<classLabel>Apoptosis and Necrosis</classLabel>
<newAxiom>'Apoptosis and Necrosis' SubClassOf 'Other Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132484</classIRI>
<classLabel>Hemangiectasis</classLabel>
<newAxiom>'Hemangiectasis' SubClassOf 'Vascular Ectasia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132487</classIRI>
<classLabel>Eosinophilic Globules</classLabel>
<newAxiom>'Eosinophilic Globules' SubClassOf 'Morphologic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132486</classIRI>
<classLabel>Ectopic Tissue</classLabel>
<newAxiom>'Ectopic Tissue' SubClassOf 'Abnormal Tissue Present'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132489</classIRI>
<classLabel>Non-clinical Contributing Scientist Name</classLabel>
<newAxiom>'Non-clinical Contributing Scientist Name' SubClassOf 'Name'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132488</classIRI>
<classLabel>Helicobacter Present</classLabel>
<newAxiom>'Helicobacter Present' SubClassOf 'Morphologic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132490</classIRI>
<classLabel>Two or More New Bone Lesions Indicator</classLabel>
<newAxiom>'Two or More New Bone Lesions Indicator' SubClassOf 'Indicator'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132492</classIRI>
<classLabel>NCCN Distress Thermometer and Problem List for Patients Version 2.2016</classLabel>
<newAxiom>'NCCN Distress Thermometer and Problem List for Patients Version 2.2016' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132491</classIRI>
<classLabel>Contract FDF Manufacturing</classLabel>
<newAxiom>'Contract FDF Manufacturing' SubClassOf 'FDF Manufacture'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132494</classIRI>
<classLabel>Neck Lymph Node Boundary Levels and Sublevels</classLabel>
<newAxiom>'Neck Lymph Node Boundary Levels and Sublevels' SubClassOf 'Other Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132493</classIRI>
<classLabel>Distress over Physical Problem with Substance Abuse</classLabel>
<newAxiom>'Distress over Physical Problem with Substance Abuse' SubClassOf 'Findings-Based Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132276</classIRI>
<classLabel>Canine Soft Tissue Sarcoma</classLabel>
<newAxiom>'Canine Soft Tissue Sarcoma' SubClassOf 'Experimental Organism Diagnosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132275</classIRI>
<classLabel>Canine Thyroid Adenocarcinoma</classLabel>
<newAxiom>'Canine Thyroid Adenocarcinoma' SubClassOf 'Experimental Organism Diagnosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132278</classIRI>
<classLabel>Sothrombomodulin Alfa</classLabel>
<newAxiom>'Sothrombomodulin Alfa' SubClassOf 'Anticoagulant Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132277</classIRI>
<classLabel>Teverelix</classLabel>
<newAxiom>'Teverelix' SubClassOf 'Gonadotropin Releasing Hormone Antagonist'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132279</classIRI>
<classLabel>Napsagatran Anhydrous</classLabel>
<newAxiom>'Napsagatran Anhydrous' SubClassOf 'Anticoagulant Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132281</classIRI>
<classLabel>Gatifloxacin Mesylate</classLabel>
<newAxiom>'Gatifloxacin Mesylate' SubClassOf 'Quinolone Antibiotic'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132280</classIRI>
<classLabel>Rhenium Re 186</classLabel>
<newAxiom>'Rhenium Re 186' SubClassOf 'Radiopharmaceutical Compound'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132283</classIRI>
<classLabel>Iodocetylic Acid I 123</classLabel>
<newAxiom>'Iodocetylic Acid I 123' SubClassOf 'Radioconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132282</classIRI>
<classLabel>General Fatigue Dimension</classLabel>
<newAxiom>'General Fatigue Dimension' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132285</classIRI>
<classLabel>Mental Fatigue Dimension</classLabel>
<newAxiom>'Mental Fatigue Dimension' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132284</classIRI>
<classLabel>Physical Fatigue Dimension</classLabel>
<newAxiom>'Physical Fatigue Dimension' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132265</classIRI>
<classLabel>Percent Change From Nadir in Sum of Products of Perpendicular Diameters</classLabel>
<newAxiom>'Percent Change From Nadir in Sum of Products of Perpendicular Diameters' SubClassOf 'Mass Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132264</classIRI>
<classLabel>Percent Change From Baseline in Sum of Products of Perpendicular Diameter</classLabel>
<newAxiom>'Percent Change From Baseline in Sum of Products of Perpendicular Diameter' SubClassOf 'Mass Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132267</classIRI>
<classLabel>Anti-GITR Agonistic Monoclonal Antibody BMS-986156</classLabel>
<newAxiom>'Anti-GITR Agonistic Monoclonal Antibody BMS-986156' SubClassOf 'Anti-GITR Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132266</classIRI>
<classLabel>Anti-CD73 Monoclonal Antibody BMS-986179</classLabel>
<newAxiom>'Anti-CD73 Monoclonal Antibody BMS-986179' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132269</classIRI>
<classLabel>Sampatrilat</classLabel>
<newAxiom>'Sampatrilat' SubClassOf 'ACE Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132268</classIRI>
<classLabel>Funisolide Anhydrous</classLabel>
<newAxiom>'Funisolide Anhydrous' SubClassOf 'Therapeutic Glucocorticoid'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132270</classIRI>
<classLabel>46,XY Sex Reversal 4</classLabel>
<newAxiom>'46,XY Sex Reversal 4' SubClassOf '46,XY Differences of Sex Development'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132272</classIRI>
<classLabel>Iometopane I 123</classLabel>
<newAxiom>'Iometopane I 123' SubClassOf 'Radioconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132271</classIRI>
<classLabel>Oxeclosporin</classLabel>
<newAxiom>'Oxeclosporin' SubClassOf 'Immunosuppressant'</newAxiom>
<newAxiom>'Oxeclosporin' SubClassOf 'Nitrogen Mustard Compound'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132274</classIRI>
<classLabel>Feline Mammary Carcinoma</classLabel>
<newAxiom>'Feline Mammary Carcinoma' SubClassOf 'Experimental Organism Diagnosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132273</classIRI>
<classLabel>Milameline</classLabel>
<newAxiom>'Milameline' SubClassOf 'Cholinergic Agonist'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132298</classIRI>
<classLabel>CDISC Protocol Terminology</classLabel>
<newAxiom>'CDISC Protocol Terminology' SubClassOf 'Clinical Data Interchange Standards Consortium Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132297</classIRI>
<classLabel>Plasma Cell Enrichment</classLabel>
<newAxiom>'Plasma Cell Enrichment' SubClassOf 'Hematology Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132299</classIRI>
<classLabel>Protocol Identifier</classLabel>
<newAxiom>'Protocol Identifier' SubClassOf 'Identifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132287</classIRI>
<classLabel>Reduced Activity Dimension</classLabel>
<newAxiom>'Reduced Activity Dimension' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132286</classIRI>
<classLabel>Reduced Motivation Dimension</classLabel>
<newAxiom>'Reduced Motivation Dimension' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132289</classIRI>
<classLabel>Functional Disability</classLabel>
<newAxiom>'Functional Disability' SubClassOf 'Disability'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132288</classIRI>
<classLabel>Health Assessment Questionnaire Disability Index</classLabel>
<newAxiom>'Health Assessment Questionnaire Disability Index' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132290</classIRI>
<classLabel>Carbonic Anhydrase I Deficiency</classLabel>
<newAxiom>'Carbonic Anhydrase I Deficiency' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132292</classIRI>
<classLabel>Presynaptic Congenital Myasthenic Syndrome 6</classLabel>
<newAxiom>'Presynaptic Congenital Myasthenic Syndrome 6' SubClassOf 'Congenital Myasthenic Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132291</classIRI>
<classLabel>Procaine Merethoxylline</classLabel>
<newAxiom>'Procaine Merethoxylline' SubClassOf 'Anesthetic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132294</classIRI>
<classLabel>Recurrent Endometrial Serous Adenocarcinoma</classLabel>
<newAxiom>'Recurrent Endometrial Serous Adenocarcinoma' EquivalentTo 'Endometrial Serous Adenocarcinoma' and 'Recurrent Uterine Corpus Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132293</classIRI>
<classLabel>Severe Neonatal Encephalopathy Due to MECP2 Mutations</classLabel>
<newAxiom>'Severe Neonatal Encephalopathy Due to MECP2 Mutations' SubClassOf 'Neonatal Encephalopathy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132296</classIRI>
<classLabel>Atypical Pituitary Gland Adenoma</classLabel>
<newAxiom>'Atypical Pituitary Gland Adenoma' EquivalentTo 'Pituitary Gland Adenoma' and ('Disease_Has_Finding' some 'High Mitotic Activity') and ('Disease_May_Have_Finding' some 'Invasive Lesion')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132295</classIRI>
<classLabel>RET Mutation/Fusion Inhibitor BLU-667</classLabel>
<newAxiom>'RET Mutation/Fusion Inhibitor BLU-667' SubClassOf 'Tyrosine Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132239</classIRI>
<classLabel>CD70 Positive</classLabel>
<newAxiom>'CD70 Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132232</classIRI>
<classLabel>GATA1 Exon 3 Mutation</classLabel>
<newAxiom>'GATA1 Exon 3 Mutation' SubClassOf 'GATA1 Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132231</classIRI>
<classLabel>FCER2 Positive</classLabel>
<newAxiom>'FCER2 Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132234</classIRI>
<classLabel>TFE3 Positive</classLabel>
<newAxiom>'TFE3 Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132233</classIRI>
<classLabel>GATA1 Exon 2 Mutation</classLabel>
<newAxiom>'GATA1 Exon 2 Mutation' SubClassOf 'GATA1 Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132236</classIRI>
<classLabel>NTRK3 Fusion Positive</classLabel>
<newAxiom>'NTRK3 Fusion Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132235</classIRI>
<classLabel>NTRK2 Fusion Positive</classLabel>
<newAxiom>'NTRK2 Fusion Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132238</classIRI>
<classLabel>HLA-A*02:01/TP53aa264-272 Complex</classLabel>
<newAxiom>'HLA-A*02:01/TP53aa264-272 Complex' SubClassOf 'Peptide/MHC Complex'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132237</classIRI>
<classLabel>NR3C1 Positive</classLabel>
<newAxiom>'NR3C1 Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132241</classIRI>
<classLabel>LYPD3 wt Allele</classLabel>
<newAxiom>'LYPD3 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '19q13.31'</newAxiom>
<newAxiom>'LYPD3 wt Allele' SubClassOf 'LYPD3 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132240</classIRI>
<classLabel>LYPD3 Gene</classLabel>
<newAxiom>'LYPD3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Protein-Protein Interaction'</newAxiom>
<newAxiom>'LYPD3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cellular Migration Process'</newAxiom>
<newAxiom>'LYPD3 Gene' SubClassOf 'Ligand Binding Protein Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132229</classIRI>
<classLabel>RAS Family Gene Mutation</classLabel>
<newAxiom>'RAS Family Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'NRAS Gene'</newAxiom>
<newAxiom>'RAS Family Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'KRAS Gene'</newAxiom>
<newAxiom>'RAS Family Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'HRAS Gene'</newAxiom>
<newAxiom>'RAS Family Gene Mutation' SubClassOf 'Gene Abnormality'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132228</classIRI>
<classLabel>CD33 Positive</classLabel>
<newAxiom>'CD33 Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132223</classIRI>
<classLabel>Supplemental Testing</classLabel>
<newAxiom>'Supplemental Testing' SubClassOf 'Clinical Testing'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132225</classIRI>
<classLabel>Venous Segment</classLabel>
<newAxiom>'Venous Segment' SubClassOf 'Vein'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132224</classIRI>
<classLabel>Ataxia-Telangiectasisa-Like Disorder 1</classLabel>
<newAxiom>'Ataxia-Telangiectasisa-Like Disorder 1' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132227</classIRI>
<classLabel>CREBBP Gene Mutation</classLabel>
<newAxiom>'CREBBP Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'CREBBP Gene'</newAxiom>
<newAxiom>'CREBBP Gene Mutation' SubClassOf 'Gene Mutant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132226</classIRI>
<classLabel>CDKN2A-p16 Negative</classLabel>
<newAxiom>'CDKN2A-p16 Negative' SubClassOf 'CDKN2A Negative'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132230</classIRI>
<classLabel>CD79B Positive</classLabel>
<newAxiom>'CD79B Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132254</classIRI>
<classLabel>BTK Gene Mutation</classLabel>
<newAxiom>'BTK Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'BTK Gene'</newAxiom>
<newAxiom>'BTK Gene Mutation' SubClassOf 'Gene Mutant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132253</classIRI>
<classLabel>Cooperative Donor Registry</classLabel>
<newAxiom>'Cooperative Donor Registry' SubClassOf 'Database'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132256</classIRI>
<classLabel>Unspecified Tissue</classLabel>
<newAxiom>'Unspecified Tissue' SubClassOf 'Tissue'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132255</classIRI>
<classLabel>SmartPill</classLabel>
<newAxiom>'SmartPill' SubClassOf 'Diagnostic, Therapeutic, or Research Equipment'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132258</classIRI>
<classLabel>STING Agonist MK-1454</classLabel>
<newAxiom>'STING Agonist MK-1454' SubClassOf 'Antineoplastic Immunomodulating Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132257</classIRI>
<classLabel>Idronoxil Suppository NOX66</classLabel>
<newAxiom>'Idronoxil Suppository NOX66' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'DNA Repair Inhibition'</newAxiom>
<newAxiom>'Idronoxil Suppository NOX66' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'Multidrug Resistance Inhibition'</newAxiom>
<newAxiom>'Idronoxil Suppository NOX66' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'Idronoxil Suppository NOX66' SubClassOf 'Chemical_Or_Drug_Has_Mechanism_Of_Action' some 'Enzyme Inhibition'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132259</classIRI>
<classLabel>Study Site Dissolved</classLabel>
<newAxiom>'Study Site Dissolved' SubClassOf 'Study Site Status'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132261</classIRI>
<classLabel>Sum of Products of Perpendicular Diameters</classLabel>
<newAxiom>'Sum of Products of Perpendicular Diameters' SubClassOf 'Sum'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132260</classIRI>
<classLabel>Small Intestinal Myeloid Sarcoma</classLabel>
<newAxiom>'Small Intestinal Myeloid Sarcoma' EquivalentTo 'Myeloid Sarcoma' and 'Malignant Small Intestinal Neoplasm' and ('Disease_Has_Primary_Anatomic_Site' some 'Small Intestine') and ('Disease_May_Have_Finding' some 'Abdominal Pain') and ('Disease_May_Have_Finding' some 'Small Intestinal Obstruction')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132263</classIRI>
<classLabel>CDISC SDTM Microscopic Findings Test Code Terminology</classLabel>
<newAxiom>'CDISC SDTM Microscopic Findings Test Code Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132262</classIRI>
<classLabel>CDISC SDTM Microscopic Findings Test Name Terminology</classLabel>
<newAxiom>'CDISC SDTM Microscopic Findings Test Name Terminology' SubClassOf 'CDISC SDTM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132243</classIRI>
<classLabel>LYPD3 Positive</classLabel>
<newAxiom>'LYPD3 Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132242</classIRI>
<classLabel>Ly6/PLAUR Domain-Containing Protein 3</classLabel>
<newAxiom>'Ly6/PLAUR Domain-Containing Protein 3' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane'</newAxiom>
<newAxiom>'Ly6/PLAUR Domain-Containing Protein 3' SubClassOf 'Ligand Binding Protein'</newAxiom>
<newAxiom>'Ly6/PLAUR Domain-Containing Protein 3' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Protein-Protein Interaction'</newAxiom>
<newAxiom>'Ly6/PLAUR Domain-Containing Protein 3' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Outer Leaflet of the Lipid Bilayer'</newAxiom>
<newAxiom>'Ly6/PLAUR Domain-Containing Protein 3' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Cellular Migration Process'</newAxiom>
<newAxiom>'Ly6/PLAUR Domain-Containing Protein 3' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'LYPD3 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132245</classIRI>
<classLabel>CD19 Negative</classLabel>
<newAxiom>'CD19 Negative' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132244</classIRI>
<classLabel>FGFR Gene Fusion Positive</classLabel>
<newAxiom>'FGFR Gene Fusion Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132247</classIRI>
<classLabel>Chromosome Arm 9p Loss of Heterozygosity</classLabel>
<newAxiom>'Chromosome Arm 9p Loss of Heterozygosity' SubClassOf 'Chromosomal Deletion'</newAxiom>
<newAxiom>'Chromosome Arm 9p Loss of Heterozygosity' SubClassOf 'Cytogenetic_Abnormality_Involves_Chromosome' some 'Chromosome 9'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132246</classIRI>
<classLabel>Chromosome Arm 3p Loss of Heterozygosity</classLabel>
<newAxiom>'Chromosome Arm 3p Loss of Heterozygosity' SubClassOf 'Cytogenetic_Abnormality_Involves_Chromosome' some 'Chromosome 3'</newAxiom>
<newAxiom>'Chromosome Arm 3p Loss of Heterozygosity' SubClassOf 'Chromosomal Deletion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132249</classIRI>
<classLabel>Recombinant Human Bone Morphogenetic Protein 2</classLabel>
<newAxiom>'Recombinant Human Bone Morphogenetic Protein 2' SubClassOf 'Agent Affecting Musculoskeletal System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132248</classIRI>
<classLabel>AJCC v8 Stage</classLabel>
<newAxiom>'AJCC v8 Stage' SubClassOf 'Disease Stage Qualifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132250</classIRI>
<classLabel>Anti-TGF-beta Monoclonal Antibody NIS793</classLabel>
<newAxiom>'Anti-TGF-beta Monoclonal Antibody NIS793' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132252</classIRI>
<classLabel>Anti-PD-1 Monoclonal Antibody BI 754091</classLabel>
<newAxiom>'Anti-PD-1 Monoclonal Antibody BI 754091' SubClassOf 'Anti-PD1 Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132251</classIRI>
<classLabel>Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes</classLabel>
<newAxiom>'Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes' SubClassOf 'Chemical_Or_Drug_Has_Mechanism_Of_Action' some 'Antigen Sensitization'</newAxiom>
<newAxiom>'Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
<newAxiom>'Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'T-Cell Activation'</newAxiom>
<newAxiom>'Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'Immunopotentiation'</newAxiom>
<newAxiom>'Autologous PD-1-targeted Chimeric Switch Receptor-modified T Lymphocytes' SubClassOf 'Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue' some 'Cytotoxic T-Lymphocyte'</newAxiom>
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<classLabel>Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8' EquivalentTo 'Oropharyngeal (p16-Negative) Carcinoma by AJCC v8 Stage' and 'Stage III Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage III')</newAxiom>
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<newClass>
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<newAxiom>'Rilimogene Galvacirepvec/Rilimogene Glafolivec' SubClassOf 'Fowlpox Virus Vaccine'</newAxiom>
<newAxiom>'Rilimogene Galvacirepvec/Rilimogene Glafolivec' SubClassOf 'Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue' some 'Cytotoxic T-Lymphocyte'</newAxiom>
<newAxiom>'Rilimogene Galvacirepvec/Rilimogene Glafolivec' SubClassOf 'Vaccinia Vaccine'</newAxiom>
<newAxiom>'Rilimogene Galvacirepvec/Rilimogene Glafolivec' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'T-Cell Activation'</newAxiom>
<newAxiom>'Rilimogene Galvacirepvec/Rilimogene Glafolivec' SubClassOf 'Chemical_Or_Drug_Has_Mechanism_Of_Action' some 'Gene Regulation Process'</newAxiom>
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<classLabel>Oropharyngeal (p16-Negative) Carcinoma by AJCC v8 Stage</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Carcinoma by AJCC v8 Stage' EquivalentTo 'Pharyngeal Carcinoma by AJCC v8 Stage' and 'Oropharyngeal Carcinoma' and ('Disease_Has_Finding' some 'Human Papillomavirus Negative')</newAxiom>
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<classLabel>Stage I Oropharyngeal (p16-Negative) Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage I Oropharyngeal (p16-Negative) Carcinoma AJCC v8' EquivalentTo 'Oropharyngeal (p16-Negative) Carcinoma by AJCC v8 Stage' and 'Stage I Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage I')</newAxiom>
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<classLabel>Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes</classLabel>
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</newClass>
<newClass>
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<classLabel>Hypopharyngeal Cancer Clinical Distant Metastasis TNM Finding v8</classLabel>
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<classLabel>Oropharyngeal (p16-Negative) Cancer Pathologic Distant Metastasis TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer Pathologic Distant Metastasis TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic TNM Finding v8'</newAxiom>
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<classLabel>Oropharyngeal (p16-Negative) Cancer cM1 TNM Finding v8</classLabel>
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<classLabel>Oropharyngeal (p16-Negative) Cancer cM0 TNM Finding v8</classLabel>
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</newClass>
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</newClass>
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</newClass>
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</newClass>
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</newClass>
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<newAxiom>'Hypopharyngeal Cancer cN2b TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer cN2 TNM Finding v8'</newAxiom>
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<newAxiom>'Hypopharyngeal Cancer pN0 TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132961</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer pN0 TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer pN0 TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132964</classIRI>
<classLabel>Hypopharyngeal Cancer pN1 TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer pN1 TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132963</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer pN1 TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer pN1 TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132911</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer Clinical TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer Clinical TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer TNM Finding v8'</newAxiom>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer Clinical TNM Finding v8' SubClassOf 'Head and Neck Cancer Clinical TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132910</classIRI>
<classLabel>Hypopharyngeal Cancer TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) and Hypopharyngeal Cancer TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132913</classIRI>
<classLabel>Hypopharyngeal Cancer Clinical TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer Clinical TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer TNM Finding v8'</newAxiom>
<newAxiom>'Hypopharyngeal Cancer Clinical TNM Finding v8' SubClassOf 'Head and Neck Cancer Clinical TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132912</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer Pathologic TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer Pathologic TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer TNM Finding v8'</newAxiom>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer Pathologic TNM Finding v8' SubClassOf 'Head and Neck Cancer Pathologic TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132915</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132914</classIRI>
<classLabel>Hypopharyngeal Cancer Pathologic TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer Pathologic TNM Finding v8' SubClassOf 'Head and Neck Cancer Pathologic TNM Finding v8'</newAxiom>
<newAxiom>'Hypopharyngeal Cancer Pathologic TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132917</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer pTis TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer pTis TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132916</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer pTX TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer pTX TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132919</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer pT2 TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer pT2 TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132918</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer pT1 TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer pT1 TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132900</classIRI>
<classLabel>Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8' EquivalentTo 'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Pathologic Stage' and 'Stage III Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage III')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132902</classIRI>
<classLabel>MGMT-Unmethylated Glioblastoma</classLabel>
<newAxiom>'MGMT-Unmethylated Glioblastoma' EquivalentTo 'Glioblastoma' and ('Disease_Has_Finding' some 'Unmethylated MGMT Promoter')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132901</classIRI>
<classLabel>Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8' EquivalentTo 'HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Pathologic Stage' and 'Stage IV Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IV')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132904</classIRI>
<classLabel>Satisfied with How Much Work I Can Do</classLabel>
<newAxiom>'Satisfied with How Much Work I Can Do' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132903</classIRI>
<classLabel>PROMIS-29 Adult Profile v1.0</classLabel>
<newAxiom>'PROMIS-29 Adult Profile v1.0' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132906</classIRI>
<classLabel>Satisfied with Ability to do Regular Personal and Household Responsibilities</classLabel>
<newAxiom>'Satisfied with Ability to do Regular Personal and Household Responsibilities' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132905</classIRI>
<classLabel>Satisfied with Ability to Work</classLabel>
<newAxiom>'Satisfied with Ability to Work' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132908</classIRI>
<classLabel>Oropharyngeal (p16-Negative) and Hypopharyngeal Cancer TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) and Hypopharyngeal Cancer TNM Finding v8' SubClassOf 'Pharyngeal Cancer TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132907</classIRI>
<classLabel>Satisfied with Ability to Perform Daily Routine</classLabel>
<newAxiom>'Satisfied with Ability to Perform Daily Routine' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132909</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) and Hypopharyngeal Cancer TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132933</classIRI>
<classLabel>Hypopharyngeal Cancer pT4a TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer pT4a TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer pT4 TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132932</classIRI>
<classLabel>Hypopharyngeal Cancer pT4 TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer pT4 TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132935</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer Clinical Regional Lymph Nodes TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer Clinical Regional Lymph Nodes TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Clinical TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132934</classIRI>
<classLabel>Hypopharyngeal Cancer pT4b TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer pT4b TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer pT4 TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132937</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer Pathologic Regional Lymph Nodes TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer Pathologic Regional Lymph Nodes TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132936</classIRI>
<classLabel>Hypopharyngeal Cancer Clinical Regional Lymph Nodes TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer Clinical Regional Lymph Nodes TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Clinical TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132939</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer cNX TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer cNX TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Clinical Regional Lymph Nodes TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132938</classIRI>
<classLabel>Hypopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Pathologic TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132931</classIRI>
<classLabel>Hypopharyngeal Cancer pT3 TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer pT3 TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132930</classIRI>
<classLabel>Hypopharyngeal Cancer pT2 TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer pT2 TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132922</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer pT4 TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer pT4 TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132921</classIRI>
<classLabel>Linear Structural Repeat Unit Connection Points</classLabel>
<newAxiom>'Linear Structural Repeat Unit Connection Points' SubClassOf 'Spatial Orientation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132924</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer pT4a TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer pT4a TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer pT4 TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132923</classIRI>
<classLabel>Structural Repeat Unit Substitution Point</classLabel>
<newAxiom>'Structural Repeat Unit Substitution Point' SubClassOf 'Spatial Orientation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132926</classIRI>
<classLabel>Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Pathologic TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132925</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer pT4b TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer pT4b TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer pT4 TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132928</classIRI>
<classLabel>Hypopharyngeal Cancer pTis TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer pTis TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132927</classIRI>
<classLabel>Hypopharyngeal Cancer pTX TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer pTX TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132920</classIRI>
<classLabel>Oropharyngeal (p16-Negative) Cancer pT3 TNM Finding v8</classLabel>
<newAxiom>'Oropharyngeal (p16-Negative) Cancer pT3 TNM Finding v8' SubClassOf 'Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132929</classIRI>
<classLabel>Hypopharyngeal Cancer pT1 TNM Finding v8</classLabel>
<newAxiom>'Hypopharyngeal Cancer pT1 TNM Finding v8' SubClassOf 'Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133009</classIRI>
<classLabel>Stage IVA Hypopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage IVA Hypopharyngeal Carcinoma AJCC v8' EquivalentTo 'Stage IV Hypopharyngeal Carcinoma AJCC v8' and 'Stage IVA Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IVA')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133003</classIRI>
<classLabel>Hypopharyngeal Carcinoma by AJCC v8 Stage</classLabel>
<newAxiom>'Hypopharyngeal Carcinoma by AJCC v8 Stage' EquivalentTo 'Pharyngeal Carcinoma by AJCC v8 Stage' and 'Hypopharyngeal Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133004</classIRI>
<classLabel>Stage 0 Hypopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage 0 Hypopharyngeal Carcinoma AJCC v8' EquivalentTo 'Hypopharyngeal Carcinoma by AJCC v8 Stage' and 'Stage 0 Pharyngeal Cancer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133001</classIRI>
<classLabel>Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8' EquivalentTo 'Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8' and 'Stage IVB Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IVB')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133002</classIRI>
<classLabel>Stage IVC Oropharyngeal (p16-Negative) Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage IVC Oropharyngeal (p16-Negative) Carcinoma AJCC v8' EquivalentTo 'Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8' and 'Stage IVC Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IVC')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133007</classIRI>
<classLabel>Stage III Hypopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage III Hypopharyngeal Carcinoma AJCC v8' EquivalentTo 'Hypopharyngeal Carcinoma by AJCC v8 Stage' and 'Stage III Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage III')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133008</classIRI>
<classLabel>Stage IV Hypopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage IV Hypopharyngeal Carcinoma AJCC v8' EquivalentTo 'Hypopharyngeal Carcinoma by AJCC v8 Stage' and 'Stage IV Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IV')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133005</classIRI>
<classLabel>Stage I Hypopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage I Hypopharyngeal Carcinoma AJCC v8' EquivalentTo 'Hypopharyngeal Carcinoma by AJCC v8 Stage' and 'Stage I Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage I')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133006</classIRI>
<classLabel>Stage II Hypopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage II Hypopharyngeal Carcinoma AJCC v8' EquivalentTo 'Hypopharyngeal Carcinoma by AJCC v8 Stage' and 'Stage II Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage II')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133010</classIRI>
<classLabel>Stage IVB Hypopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage IVB Hypopharyngeal Carcinoma AJCC v8' EquivalentTo 'Stage IV Hypopharyngeal Carcinoma AJCC v8' and 'Stage IVB Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IVB')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133011</classIRI>
<classLabel>Stage IVC Hypopharyngeal Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage IVC Hypopharyngeal Carcinoma AJCC v8' EquivalentTo 'Stage IV Hypopharyngeal Carcinoma AJCC v8' and 'Stage IVC Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IVC')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133000</classIRI>
<classLabel>Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8</classLabel>
<newAxiom>'Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8' EquivalentTo 'Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8' and 'Stage IVA Pharyngeal Cancer' and ('Disease_Is_Stage' some 'Stage IVA')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133023</classIRI>
<classLabel>Iodine I 131 Iodocholesterol</classLabel>
<newAxiom>'Iodine I 131 Iodocholesterol' SubClassOf 'Radioconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133014</classIRI>
<classLabel>Regret Choice Made</classLabel>
<newAxiom>'Regret Choice Made' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133015</classIRI>
<classLabel>Would Make Same Choice Again</classLabel>
<newAxiom>'Would Make Same Choice Again' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133012</classIRI>
<classLabel>Decision Regret Scale</classLabel>
<newAxiom>'Decision Regret Scale' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133013</classIRI>
<classLabel>Made Right Decision</classLabel>
<newAxiom>'Made Right Decision' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133018</classIRI>
<classLabel>Untreated Adult Rhabdomyosarcoma</classLabel>
<newAxiom>'Untreated Adult Rhabdomyosarcoma' SubClassOf 'Musculoskeletal Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133019</classIRI>
<classLabel>Proapoptotic Sulindac Analog CP-461</classLabel>
<newAxiom>'Proapoptotic Sulindac Analog CP-461' SubClassOf 'Antineoplastic Agent'</newAxiom>
<newAxiom>'Proapoptotic Sulindac Analog CP-461' SubClassOf 'Phosphodiesterase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133016</classIRI>
<classLabel>Choice Did Harm</classLabel>
<newAxiom>'Choice Did Harm' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133017</classIRI>
<classLabel>Decision was Wise</classLabel>
<newAxiom>'Decision was Wise' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133021</classIRI>
<classLabel>Gelonin</classLabel>
<newAxiom>'Gelonin' SubClassOf 'Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133022</classIRI>
<classLabel>Anti-Ep-CAM Monoclonal Antibody ING-1</classLabel>
<newAxiom>'Anti-Ep-CAM Monoclonal Antibody ING-1' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133020</classIRI>
<classLabel>Gallium Maltolate</classLabel>
<newAxiom>'Gallium Maltolate' SubClassOf 'Chemical_Or_Drug_Has_Mechanism_Of_Action' some 'Unknown Cellular or Molecular Mechanism'</newAxiom>
<newAxiom>'Gallium Maltolate' SubClassOf 'Bone Resorption Inhibitor'</newAxiom>
<newAxiom>'Gallium Maltolate' SubClassOf 'Antineoplastic Agent'</newAxiom>
<newAxiom>'Gallium Maltolate' SubClassOf 'Malignancy-Associated Hypercalcemia Inhibitor'</newAxiom>
<newAxiom>'Gallium Maltolate' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'Positive Regulation of Apoptosis'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
</deletedClasses>
</diffReport>