<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
875
</numberChangedClasses>
<numberNewClasses>
295
</numberNewClasses>
<numberDeletedClasses>
0
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19920</classIRI>
<classLabel>Thyroid Hormone Receptor Alpha</classLabel>
<deletedAxiom>&apos;Thyroid Hormone Receptor Alpha&apos; EquivalentTo &apos;Thyroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Map Kinase Inactivation of SMRT Corepressor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Central Nervous System&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Thyroid Hormone Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;THRA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Thyroid Hormone Receptor Alpha&apos; EquivalentTo &apos;Thyroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Map Kinase Inactivation of SMRT Corepressor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Central Nervous System&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;THRA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34566</classIRI>
<classLabel>Congenital Ectopic Lens</classLabel>
<newAxiom>&apos;Congenital Ectopic Lens&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125484</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34556</classIRI>
<classLabel>Dyschondroplasia</classLabel>
<deletedAxiom>&apos;Dyschondroplasia&apos; SubClassOf &apos;Non-Neoplastic Bone Disorder&apos;</deletedAxiom>
<newAxiom>&apos;Dyschondroplasia&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40064</classIRI>
<classLabel>Cytochrome P450 11B2, Mitochondrial</classLabel>
<deletedAxiom>&apos;Cytochrome P450 11B2, Mitochondrial&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP11B2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 11B2, Mitochondrial&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP11B2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40068</classIRI>
<classLabel>Steroid 17-Alpha-Hydroxylase/17,20 Lyase</classLabel>
<deletedAxiom>&apos;Steroid 17-Alpha-Hydroxylase/17,20 Lyase&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Sexual Maturation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP17A1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Steroid 17-Alpha-Hydroxylase/17,20 Lyase&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Sexual Maturation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP17A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40050</classIRI>
<classLabel>Cytochrome P450 2B6</classLabel>
<deletedAxiom>&apos;Cytochrome P450 2B6&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2B6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 2B6&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2B6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40053</classIRI>
<classLabel>Cholesterol 7-Alpha-Monooxygenase</classLabel>
<deletedAxiom>&apos;Cholesterol 7-Alpha-Monooxygenase&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP7A1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cholesterol 7-Alpha-Monooxygenase&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP7A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40055</classIRI>
<classLabel>7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase</classLabel>
<deletedAxiom>&apos;7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP8B1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP8B1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40057</classIRI>
<classLabel>Cholesterol Side-Chain Cleavage Enzyme, Mitochondrial</classLabel>
<deletedAxiom>&apos;Cholesterol Side-Chain Cleavage Enzyme, Mitochondrial&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP11A1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cholesterol Side-Chain Cleavage Enzyme, Mitochondrial&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP11A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40059</classIRI>
<classLabel>Cytochrome P450 CYP11B1, Mitochondrial</classLabel>
<deletedAxiom>&apos;Cytochrome P450 CYP11B1, Mitochondrial&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP11B1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 CYP11B1, Mitochondrial&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP11B1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63508</classIRI>
<classLabel>Chromosome-Associated Kinesin KIF4A Protein</classLabel>
<deletedAxiom>&apos;Chromosome-Associated Kinesin KIF4A Protein&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;Cell Cycle Gene&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C122075</classIRI>
<classLabel>Matrix Metalloproteinase-16</classLabel>
<deletedAxiom>&apos;Matrix Metalloproteinase-16&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Matrix Metalloproteinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19705</classIRI>
<classLabel>Prostaglandin G/H Synthase 1</classLabel>
<deletedAxiom>&apos;Prostaglandin G/H Synthase 1&apos; EquivalentTo &apos;Cyclooxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostaglandin and Leukotriene Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acetaminophen Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclooxygenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTGS1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Prostaglandin G/H Synthase 1&apos; EquivalentTo &apos;Cyclooxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostaglandin and Leukotriene Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acetaminophen Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTGS1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40074</classIRI>
<classLabel>25-Hydroxyvitamin D-1 Alpha-Hydroxylase, Mitochondrial</classLabel>
<deletedAxiom>&apos;25-Hydroxyvitamin D-1 Alpha-Hydroxylase, Mitochondrial&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP27B1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;25-Hydroxyvitamin D-1 Alpha-Hydroxylase, Mitochondrial&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP27B1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40071</classIRI>
<classLabel>Steroid 21-Hydroxylase</classLabel>
<deletedAxiom>&apos;Steroid 21-Hydroxylase&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP21A2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Steroid 21-Hydroxylase&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP21A2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115984</classIRI>
<classLabel>Alpha-Protein Kinase 2</classLabel>
<deletedAxiom>&apos;Alpha-Protein Kinase 2&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40249</classIRI>
<classLabel>SET and MYND Domain-Containing Protein 3</classLabel>
<deletedAxiom>&apos;SET and MYND Domain-Containing Protein 3&apos; EquivalentTo &apos;Methyltransferase&apos; and &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SET Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Binding Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Methylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMYD3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SET and MYND Domain-Containing Protein 3&apos; EquivalentTo &apos;Methyltransferase&apos; and &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SET Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Methylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMYD3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19887</classIRI>
<classLabel>Histone Acetyltransferase KAT5</classLabel>
<deletedAxiom>&apos;Histone Acetyltransferase KAT5&apos; EquivalentTo &apos;Histone Acetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Acetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Acetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KAT5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Acetyltransferase KAT5&apos; EquivalentTo &apos;Histone Acetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Acetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KAT5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26194</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-2</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-2&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNB2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-2&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNB2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26195</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hypertension&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNB3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hypertension&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNB3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26193</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-1</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-1&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Desensitization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Corticosteroid Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Kinase A Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channels in Vascular Endothelium Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tubby Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNB1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-1&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Desensitization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Corticosteroid Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Kinase A Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channels in Vascular Endothelium Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tubby Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNB1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26189</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein Subunit Alpha-12</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein Subunit Alpha-12&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNA12 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein Subunit Alpha-12&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNA12 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26186</classIRI>
<classLabel>G Protein-Coupled Receptor Kinase-Interactor 2</classLabel>
<deletedAxiom>&apos;G Protein-Coupled Receptor Kinase-Interactor 2&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GIT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G Protein-Coupled Receptor Kinase-Interactor 2&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GIT2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26188</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein G(z) Subunit Alpha</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein G(z) Subunit Alpha&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNAZ Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein G(z) Subunit Alpha&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G(i) Alpha&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNAZ Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26183</classIRI>
<classLabel>Gastric Inhibitory Polypeptide Receptor</classLabel>
<deletedAxiom>&apos;Gastric Inhibitory Polypeptide Receptor&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GIPR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Gastric Inhibitory Polypeptide Receptor&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GIPR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26184</classIRI>
<classLabel>ARF GTPase-Activating Protein GIT1</classLabel>
<deletedAxiom>&apos;ARF GTPase-Activating Protein GIT1&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GIT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;ARF GTPase-Activating Protein GIT1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
<newAxiom>&apos;ARF GTPase-Activating Protein GIT1&apos; SubClassOf &apos;GTPase-Activating Protein&apos;</newAxiom>
<newAxiom>&apos;ARF GTPase-Activating Protein GIT1&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GIT1 Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C122293</classIRI>
<classLabel>Encephalitozoon</classLabel>
<deletedAxiom>&apos;Encephalitozoon&apos; SubClassOf &apos;Ascomycota&apos;</deletedAxiom>
<newAxiom>&apos;Encephalitozoon&apos; SubClassOf &apos;Microsporidia&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26112</classIRI>
<classLabel>DNA (Cytosine-5)-Methyltransferase 3B</classLabel>
<deletedAxiom>&apos;DNA (Cytosine-5)-Methyltransferase 3B&apos; EquivalentTo &apos;DNA Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PWWP Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADD-Type Zinc-Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNMT3B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA (Cytosine-5)-Methyltransferase 3B&apos; EquivalentTo &apos;DNA Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PWWP Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADD-Type Zinc-Finger&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNMT3B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26116</classIRI>
<classLabel>Dedicator of Cytokinesis Protein 1</classLabel>
<deletedAxiom>&apos;Dedicator of Cytokinesis Protein 1&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Surface Extension&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DOCK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dedicator of Cytokinesis Protein 1&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Surface Extension&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DOCK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96021</classIRI>
<classLabel>Activin Receptor Type-1C</classLabel>
<deletedAxiom>&apos;Activin Receptor Type-1C&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Serine/Threonine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVR1C Gene&apos;)</deletedAxiom>
<deletedAxiom>&apos;Activin Receptor Type-1C&apos; SubClassOf &apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;</deletedAxiom>
<newAxiom>&apos;Activin Receptor Type-1C&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVR1C Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26129</classIRI>
<classLabel>Fibroblast Growth Factor Receptor 3</classLabel>
<deletedAxiom>&apos;Fibroblast Growth Factor Receptor 3&apos; EquivalentTo &apos;Fibroblast Growth Factor Receptor Family&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Growth Factor Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGFR3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fibroblast Growth Factor Receptor 3&apos; EquivalentTo &apos;Fibroblast Growth Factor Receptor Family&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Growth Factor Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGFR3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96039</classIRI>
<classLabel>Disintegrin and Metalloproteinase Domain-Containing Protein 12</classLabel>
<deletedAxiom>&apos;Disintegrin and Metalloproteinase Domain-Containing Protein 12&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;ADAM Family Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Disintegrin Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADAM Type Metalloprotease Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAM12 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Disintegrin and Metalloproteinase Domain-Containing Protein 12&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;ADAM Family Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Disintegrin Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADAM Type Metalloprotease Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAM12 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26107</classIRI>
<classLabel>Deleted in Malignant Brain Tumors 1 Protein</classLabel>
<deletedAxiom>&apos;Deleted in Malignant Brain Tumors 1 Protein&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Scavenger Receptor Cysteine-Rich Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SRCR-Interspersed Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Mediated Endocytosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DMBT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Deleted in Malignant Brain Tumors 1 Protein&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Scavenger Receptor Cysteine-Rich Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SRCR-Interspersed Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Mediated Endocytosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DMBT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26103</classIRI>
<classLabel>Chemokine XC Receptor 1</classLabel>
<deletedAxiom>&apos;Chemokine XC Receptor 1&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chemotactic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;XCR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Chemokine XC Receptor 1&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chemotactic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;XCR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26100</classIRI>
<classLabel>Vasopressin V2 Receptor</classLabel>
<deletedAxiom>&apos;Vasopressin V2 Receptor&apos; EquivalentTo &apos;Vasopressin Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vasopressin-Regulated Water Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Trafficking Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AVPR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Vasopressin V2 Receptor&apos; EquivalentTo &apos;Vasopressin Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vasopressin-Regulated Water Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Trafficking Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AVPR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26133</classIRI>
<classLabel>Fas-Activated Serine/Threonine Kinase</classLabel>
<deletedAxiom>&apos;Fas-Activated Serine/Threonine Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FASTK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fas-Activated Serine/Threonine Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Splicing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FASTK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26138</classIRI>
<classLabel>Exostosin-Like 3</classLabel>
<deletedAxiom>&apos;Exostosin-Like 3&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Heparan Sulfate Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EXTL3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Exostosin-Like 3&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Heparan Sulfate Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EXTL3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26137</classIRI>
<classLabel>Exostosin-Like 2</classLabel>
<deletedAxiom>&apos;Exostosin-Like 2&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Heparan Sulfate Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EXTL2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Exostosin-Like 2&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Heparan Sulfate Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EXTL2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26136</classIRI>
<classLabel>Exostosin-Like 1</classLabel>
<deletedAxiom>&apos;Exostosin-Like 1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Heparan Sulfate Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EXTL1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Exostosin-Like 1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Heparan Sulfate Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EXTL1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26148</classIRI>
<classLabel>Thymidine Phosphorylase</classLabel>
<deletedAxiom>&apos;Thymidine Phosphorylase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Glial Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYMP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Thymidine Phosphorylase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Glial Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYMP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C122302</classIRI>
<classLabel>Enterocytozoon</classLabel>
<deletedAxiom>&apos;Enterocytozoon&apos; SubClassOf &apos;Ascomycota&apos;</deletedAxiom>
<newAxiom>&apos;Enterocytozoon&apos; SubClassOf &apos;Microsporidia&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79782</classIRI>
<classLabel>Indoleamine 2,3-Dioxygenase</classLabel>
<deletedAxiom>&apos;Indoleamine 2,3-Dioxygenase&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxygenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;INDO Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Indoleamine 2,3-Dioxygenase&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;INDO Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19678</classIRI>
<classLabel>Histone Deacetylase 5</classLabel>
<deletedAxiom>&apos;Histone Deacetylase 5&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Deacetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Deacetylase 5&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19679</classIRI>
<classLabel>Histone Deacetylase 6</classLabel>
<deletedAxiom>&apos;Histone Deacetylase 6&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Deacetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Developmental Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Deacetylase 6&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Developmental Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19672</classIRI>
<classLabel>Histone Deacetylase 3</classLabel>
<deletedAxiom>&apos;Histone Deacetylase 3&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chromatin Remodeling Complex and Coactivator Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RELA Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Deacetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Deacetylase 3&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chromatin Remodeling Complex and Coactivator Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RELA Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19671</classIRI>
<classLabel>Histone Deacetylase 1</classLabel>
<deletedAxiom>&apos;Histone Deacetylase 1&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MTA3 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Silencing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tert Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Expression Regulation by Vitamin D Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Deacetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Deacetylase 1&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MTA3 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Silencing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tert Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Expression Regulation by Vitamin D Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19673</classIRI>
<classLabel>Histone Deacetylase 4</classLabel>
<deletedAxiom>&apos;Histone Deacetylase 4&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Deacetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Deacetylase 4&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26082</classIRI>
<classLabel>Casein Kinase II Subunit Alpha</classLabel>
<deletedAxiom>&apos;Casein Kinase II Subunit Alpha&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LIS1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ribosome Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Atypical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lissencephaly-1 Gene in Neuronal Migration and Development&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-alpha Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Casein Kinase 2&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CSNK2A1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Casein Kinase II Subunit Alpha&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LIS1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ribosome Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Atypical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lissencephaly-1 Gene in Neuronal Migration and Development&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-alpha Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Casein Kinase 2&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CSNK2A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26096</classIRI>
<classLabel>Vasopressin V1A Receptor</classLabel>
<deletedAxiom>&apos;Vasopressin V1A Receptor&apos; EquivalentTo &apos;Vasopressin Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AVPR1A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Vasopressin V1A Receptor&apos; EquivalentTo &apos;Vasopressin Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AVPR1A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34084</classIRI>
<classLabel>Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Beta Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Beta Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R1B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Beta Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R1B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34083</classIRI>
<classLabel>Protein Phosphatase Regulatory Protein</classLabel>
<deletedAxiom>&apos;Protein Phosphatase Regulatory Protein&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34085</classIRI>
<classLabel>Serine/Threonine-Protein Phosphatase 2A Activator</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A Activator&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A Activator&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34080</classIRI>
<classLabel>Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2CA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2CA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34081</classIRI>
<classLabel>Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metabolic Control&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G2 to M Transition Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2CB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metabolic Control&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G2 to M Transition Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2CB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34088</classIRI>
<classLabel>Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Beta Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Beta Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R5B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Beta Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R5B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34087</classIRI>
<classLabel>Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R5A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R5A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34089</classIRI>
<classLabel>Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Gamma Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Gamma Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R5C Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Gamma Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R5C Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34075</classIRI>
<classLabel>Lipid Phosphate Phosphohydrolase 1</classLabel>
<deletedAxiom>&apos;Lipid Phosphate Phosphohydrolase 1&apos; EquivalentTo &apos;Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerophospholipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ether Lipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transport Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPAP2A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Lipid Phosphate Phosphohydrolase 1&apos; EquivalentTo &apos;Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerophospholipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ether Lipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transport Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPAP2A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34071</classIRI>
<classLabel>DNA-Directed RNA Polymerase II Subunit RPB1</classLabel>
<deletedAxiom>&apos;DNA-Directed RNA Polymerase II Subunit RPB1&apos; EquivalentTo &apos;DNA-directed RNA Polymerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pain Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;hSWI-SNF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN-Beta Enhancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chromatin Remodeling Complex and Coactivator Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Polymerase Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;RNA Polymerase II&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Binding Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Polymerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;POLR2A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA-Directed RNA Polymerase II Subunit RPB1&apos; EquivalentTo &apos;DNA-directed RNA Polymerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pain Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;hSWI-SNF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN-Beta Enhancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chromatin Remodeling Complex and Coactivator Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Polymerase Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;RNA Polymerase II&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;POLR2A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34079</classIRI>
<classLabel>Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP1CA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP1CA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34078</classIRI>
<classLabel>Protein Serine/Threonine Phosphatase</classLabel>
<deletedAxiom>&apos;Protein Serine/Threonine Phosphatase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26033</classIRI>
<classLabel>Casein Kinase I Isoform Alpha</classLabel>
<deletedAxiom>&apos;Casein Kinase I Isoform Alpha&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CSNK1A1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Casein Kinase I Isoform Alpha&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CSNK1A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34091</classIRI>
<classLabel>Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Epsilon Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Epsilon Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R5E Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Epsilon Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R5E Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34090</classIRI>
<classLabel>Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Delta Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Delta Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R5D Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Delta Isoform&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R5D Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34095</classIRI>
<classLabel>Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase</classLabel>
<deletedAxiom>&apos;Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF2 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bone Remodeling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;dsRNA Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Double-Stranded RNA Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Translation Process Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EIF2AK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF2 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bone Remodeling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;dsRNA Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Double-Stranded RNA Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Translation Process Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EIF2AK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34099</classIRI>
<classLabel>Protein-Tyrosine Kinase 6</classLabel>
<deletedAxiom>&apos;Protein-Tyrosine Kinase 6&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTK6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein-Tyrosine Kinase 6&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTK6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34065</classIRI>
<classLabel>1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3</classLabel>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLCB3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLCB3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34063</classIRI>
<classLabel>Phospholipase A2, Membrane Associated</classLabel>
<deletedAxiom>&apos;Phospholipase A2, Membrane Associated&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostaglandin and Leukotriene Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerophospholipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ether Lipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;alpha-Linolenic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Phospholipase A2 Enzyme Family&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLA2G2A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Phospholipase A2, Membrane Associated&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostaglandin and Leukotriene Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerophospholipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ether Lipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;alpha-Linolenic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Phospholipase A2 Enzyme Family&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLA2G2A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34000</classIRI>
<classLabel>Nuclear Receptor Subfamily 0 Group B Member 2</classLabel>
<deletedAxiom>&apos;Nuclear Receptor Subfamily 0 Group B Member 2&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Nuclear Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Repressor/Corepressor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR0B2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Nuclear Receptor Subfamily 0 Group B Member 2&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Repressor/Corepressor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR0B2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34010</classIRI>
<classLabel>Olfactory Receptor 1G1</classLabel>
<deletedAxiom>&apos;Olfactory Receptor 1G1&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;OR1G1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Olfactory Receptor 1G1&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;OR1G1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34020</classIRI>
<classLabel>Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 2</classLabel>
<deletedAxiom>&apos;Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 2&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;mRNA Expression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CTDSP2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 2&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;mRNA Expression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CTDSP2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34025</classIRI>
<classLabel>Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta</classLabel>
<deletedAxiom>&apos;Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIP4K2B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIP4K2B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34024</classIRI>
<classLabel>Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Alpha</classLabel>
<deletedAxiom>&apos;Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Alpha&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIP4K2A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Alpha&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIP4K2A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26371</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 6</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 6&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 6&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26370</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 4</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 4&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 4&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26379</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 9</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 9&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 9&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26378</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 7</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 7&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 7&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26383</classIRI>
<classLabel>Tyrosine-Protein Kinase Mer</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Mer&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phagocytosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MERTK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Mer&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phagocytosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MERTK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26367</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 12</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 12&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Mitogen-Activated Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK12 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 12&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK12 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26368</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 13</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 13&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Small Intestine&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Mitogen-Activated Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Keratinocyte Differentiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK13 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 13&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Small Intestine&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Keratinocyte Differentiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK13 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26365</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 10</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 10&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Mitogen-Activated Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK10 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 10&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK10 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26369</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 14</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 14&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Map Kinase Inactivation of SMRT Corepressor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th2 Cytokine Gene Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SARS Coronavirus Protease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Stress Related Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TSP-1 Induced Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;4-1BB-Dependent Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Mitogen-Activated Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK14 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 14&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Map Kinase Inactivation of SMRT Corepressor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th2 Cytokine Gene Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SARS Coronavirus Protease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Stress Related Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TSP-1 Induced Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;4-1BB-Dependent Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK14 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26364</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 11</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 11&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Mitogen-Activated Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK11 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 11&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK11 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26339</classIRI>
<classLabel>Tyrosine-Protein Phosphatase Non-Receptor Type 1</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 1&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Regulated NFAT-Dependent Transcription Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 1&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Regulated NFAT-Dependent Transcription Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26332</classIRI>
<classLabel>Leukocyte Tyrosine Kinase Receptor</classLabel>
<deletedAxiom>&apos;Leukocyte Tyrosine Kinase Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LTK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Leukocyte Tyrosine Kinase Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LTK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26345</classIRI>
<classLabel>Tyrosine-Protein Phosphatase Non-Receptor Type 7</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 7&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Downstream Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Non-Hodgkin Lymphoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 7&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Downstream Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Non-Hodgkin Lymphoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26346</classIRI>
<classLabel>Serine/Threonine-Protein Kinase LATS2</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase LATS2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1/S Transition Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LATS2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase LATS2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1/S Transition Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LATS2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26343</classIRI>
<classLabel>Tyrosine-Protein Phosphatase Non-Receptor Type 6</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 6&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Hematopoietic Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 6&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Hematopoietic Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26344</classIRI>
<classLabel>Serine/Threonine-Protein Kinase LATS1</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase LATS1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LATS1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase LATS1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LATS1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26341</classIRI>
<classLabel>Tyrosine-Protein Phosphatase Non-Receptor Type 12</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 12&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Colon Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN12 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 12&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Colon Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN12 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26342</classIRI>
<classLabel>Tyrosine-Protein Phosphatase Non-Receptor Type 22</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 22&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;B-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;T-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymocyte&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN22 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 22&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;B-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;T-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymocyte&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN22 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26327</classIRI>
<classLabel>Protein-Lysine 6-Oxidase</classLabel>
<deletedAxiom>&apos;Protein-Lysine 6-Oxidase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Colon Neoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LOX Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein-Lysine 6-Oxidase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Colon Neoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LOX Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26314</classIRI>
<classLabel>3-Keto-Steroid Reductase</classLabel>
<deletedAxiom>&apos;3-Keto-Steroid Reductase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sterol Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Breast&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HSD17B7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;3-Keto-Steroid Reductase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sterol Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Breast&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HSD17B7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26313</classIRI>
<classLabel>Heparanase</classLabel>
<deletedAxiom>&apos;Heparanase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Wound Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell-Matrix Adhesion Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HPSE Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Heparanase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Wound Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell-Matrix Adhesion Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HPSE Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19421</classIRI>
<classLabel>Glycylpeptide N-Tetradecanoyltransferase 2</classLabel>
<deletedAxiom>&apos;Glycylpeptide N-Tetradecanoyltransferase 2&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Acyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;N-Myristoylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NMT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Glycylpeptide N-Tetradecanoyltransferase 2&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;N-Myristoylation&apos;</newAxiom>
<newAxiom>&apos;Glycylpeptide N-Tetradecanoyltransferase 2&apos; SubClassOf &apos;Acyltransferase&apos;</newAxiom>
<newAxiom>&apos;Glycylpeptide N-Tetradecanoyltransferase 2&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NMT2 Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26252</classIRI>
<classLabel>Regulator of G-Protein Signaling 19</classLabel>
<deletedAxiom>&apos;Regulator of G-Protein Signaling 19&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS19 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 19&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 19&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS19 Gene&apos;</newAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 19&apos; SubClassOf &apos;RGS Family Protein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26251</classIRI>
<classLabel>Regulator of G-Protein Signaling 3</classLabel>
<deletedAxiom>&apos;Regulator of G-Protein Signaling 3&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 3&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS3 Gene&apos;</newAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 3&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 3&apos; SubClassOf &apos;RGS Family Protein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26253</classIRI>
<classLabel>Cation-Independent Mannose-6 Phosphate Receptor</classLabel>
<deletedAxiom>&apos;Cation-Independent Mannose-6 Phosphate Receptor&apos; EquivalentTo &apos;Insulin-Like Growth Factor Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Growth Factor Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Mediated Endocytosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IGF2R Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cation-Independent Mannose-6 Phosphate Receptor&apos; EquivalentTo &apos;Insulin-Like Growth Factor Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Mediated Endocytosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IGF2R Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26250</classIRI>
<classLabel>Regulator of G-Protein Signaling 2</classLabel>
<deletedAxiom>&apos;Regulator of G-Protein Signaling 2&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 2&apos; SubClassOf &apos;RGS Family Protein&apos;</newAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 2&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 2&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS2 Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26268</classIRI>
<classLabel>Interleukin-4 Receptor Subunit Alpha</classLabel>
<deletedAxiom>&apos;Interleukin-4 Receptor Subunit Alpha&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Polarization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th1/Th2 Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL4R Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interleukin-4 Receptor Subunit Alpha&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Polarization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th1/Th2 Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL4R Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26266</classIRI>
<classLabel>Cytokine Receptor Common Subunit Gamma</classLabel>
<deletedAxiom>&apos;Cytokine Receptor Common Subunit Gamma&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Downstream Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Severe Combined Immunodeficiency&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Interleukin-2 Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL2RG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytokine Receptor Common Subunit Gamma&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Downstream Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Severe Combined Immunodeficiency&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Interleukin-2 Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL2RG Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26278</classIRI>
<classLabel>Interleukin-7 Receptor Subunit Alpha</classLabel>
<deletedAxiom>&apos;Interleukin-7 Receptor Subunit Alpha&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;V(D)J Recombination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL7R Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interleukin-7 Receptor Subunit Alpha&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;V(D)J Recombination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL7R Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26271</classIRI>
<classLabel>Interleukin-11 Receptor Subunit Alpha</classLabel>
<deletedAxiom>&apos;Interleukin-11 Receptor Subunit Alpha&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;</deletedAxiom>
<deletedAxiom>&apos;Interleukin-11 Receptor Subunit Alpha&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL11RA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interleukin-11 Receptor Subunit Alpha&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL11RA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26211</classIRI>
<classLabel>Discoidin Domain-Containing Receptor 2</classLabel>
<deletedAxiom>&apos;Discoidin Domain-Containing Receptor 2&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Discoidin Domain-Containing Receptor 2&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26229</classIRI>
<classLabel>G-Protein Coupled Receptor Family C Group 5 Member C</classLabel>
<deletedAxiom>&apos;G-Protein Coupled Receptor Family C Group 5 Member C&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPRC5C Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G-Protein Coupled Receptor Family C Group 5 Member C&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPRC5C Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26227</classIRI>
<classLabel>C-X-C Chemokine Receptor Type 3</classLabel>
<deletedAxiom>&apos;C-X-C Chemokine Receptor Type 3&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Polarization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NO2-Dependent IL12 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chemokine Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chemotactic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CXCR3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;C-X-C Chemokine Receptor Type 3&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Polarization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NO2-Dependent IL12 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chemotactic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CXCR3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26231</classIRI>
<classLabel>Adaptor Signaling Protein</classLabel>
<deletedAxiom>&apos;Adaptor Signaling Protein&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;Adaptor Signaling Protein Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Adaptor Signaling Protein&apos; SubClassOf &apos;Signaling Protein&apos;</newAxiom>
<newAxiom>&apos;Adaptor Signaling Protein&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
<newAxiom>&apos;Adaptor Signaling Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;</newAxiom>
<newAxiom>&apos;Adaptor Signaling Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26232</classIRI>
<classLabel>G Protein-Coupled Receptor Kinase 4</classLabel>
<deletedAxiom>&apos;G Protein-Coupled Receptor Kinase 4&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRK4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G Protein-Coupled Receptor Kinase 4&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRK4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26233</classIRI>
<classLabel>G Protein-Coupled Receptor Kinase</classLabel>
<deletedAxiom>&apos;G Protein-Coupled Receptor Kinase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26235</classIRI>
<classLabel>G Protein-Coupled Receptor Kinase 5</classLabel>
<deletedAxiom>&apos;G Protein-Coupled Receptor Kinase 5&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRK5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G Protein-Coupled Receptor Kinase 5&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRK5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26237</classIRI>
<classLabel>G Protein-Coupled Receptor Kinase 6</classLabel>
<deletedAxiom>&apos;G Protein-Coupled Receptor Kinase 6&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRK6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G Protein-Coupled Receptor Kinase 6&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRK6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26242</classIRI>
<classLabel>G Protein-Coupled Receptor Kinase 7</classLabel>
<deletedAxiom>&apos;G Protein-Coupled Receptor Kinase 7&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cone Cell Visual Signal Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phototransduction Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Cone&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Sight&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRK7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G Protein-Coupled Receptor Kinase 7&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cone Cell Visual Signal Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phototransduction Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Cone&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Sight&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRK7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26243</classIRI>
<classLabel>Metabotropic Glutamate Receptor 6</classLabel>
<deletedAxiom>&apos;Metabotropic Glutamate Receptor 6&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRM6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Metabotropic Glutamate Receptor 6&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRM6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26247</classIRI>
<classLabel>Galanin Receptor Type 2</classLabel>
<deletedAxiom>&apos;Galanin Receptor Type 2&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GALR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Galanin Receptor Type 2&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GALR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26249</classIRI>
<classLabel>Regulator of G-Protein Signaling 1</classLabel>
<deletedAxiom>&apos;Regulator of G-Protein Signaling 1&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 1&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26206</classIRI>
<classLabel>Ovarian Cancer G-Protein Coupled Receptor 1</classLabel>
<deletedAxiom>&apos;Ovarian Cancer G-Protein Coupled Receptor 1&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;pH Homeostasis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPR68 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ovarian Cancer G-Protein Coupled Receptor 1&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;pH Homeostasis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPR68 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6209</classIRI>
<classLabel>Childhood Central Nervous System Yolk Sac Tumor</classLabel>
<deletedAxiom>&apos;Childhood Central Nervous System Yolk Sac Tumor&apos; EquivalentTo &apos;Childhood Nongerminomatous Germ Cell Tumor&apos; and &apos;Childhood Yolk Sac Tumor&apos; and &apos;Childhood Central Nervous System Germ Cell Tumor&apos; and &apos;Childhood Extragonadal Malignant Germ Cell Tumor&apos; and &apos;Central Nervous System Yolk Sac Tumor&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Central Nervous System Yolk Sac Tumor&apos; EquivalentTo &apos;Childhood Yolk Sac Tumor&apos; and &apos;Childhood Central Nervous System Germ Cell Tumor&apos; and &apos;Childhood Extragonadal Malignant Germ Cell Tumor&apos; and &apos;Central Nervous System Yolk Sac Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26562</classIRI>
<classLabel>DNA Primase Small Subunit</classLabel>
<deletedAxiom>&apos;DNA Primase Small Subunit&apos; SubClassOf &apos;Nucleotidyltransferase&apos;</deletedAxiom>
<deletedAxiom>&apos;DNA Primase Small Subunit&apos; SubClassOf &apos;DNA Replication Initiation Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;DNA Primase Small Subunit&apos; EquivalentTo (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DNA Replication Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;DNA Primase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Polymerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRIM1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Primase Small Subunit&apos; EquivalentTo &apos;Nucleotidyltransferase&apos; and &apos;DNA Replication Initiation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DNA Replication Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;DNA Primase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Polymerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRIM1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C122828</classIRI>
<classLabel>Cyclin-Dependent Kinase 4 Inhibitor D</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 4 Inhibitor D&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN2D Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 4 Inhibitor D&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN2D Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26485</classIRI>
<classLabel>Dual Specificity Mitogen-Activated Protein Kinase Kinase 6</classLabel>
<deletedAxiom>&apos;Dual Specificity Mitogen-Activated Protein Kinase Kinase 6&apos; EquivalentTo &apos;Threonine/Tyrosine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th2 Cytokine Gene Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cellular Anthrax Toxin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of p38-alpha and p38-beta Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-gamma and p38-delta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Enzyme&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Survival&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Death Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP2K6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dual Specificity Mitogen-Activated Protein Kinase Kinase 6&apos; EquivalentTo &apos;Threonine/Tyrosine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th2 Cytokine Gene Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cellular Anthrax Toxin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of p38-alpha and p38-beta Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-gamma and p38-delta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Survival&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Death Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP2K6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26487</classIRI>
<classLabel>Mitogen-Activated Protein Kinase Kinase Kinase 14</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase Kinase Kinase 14&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;dsRNA Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40/CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Enzyme&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Small Intestine&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Leukocyte&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP3K14 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase Kinase Kinase 14&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;dsRNA Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40/CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Small Intestine&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Leukocyte&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP3K14 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26488</classIRI>
<classLabel>Mitogen-Activated Protein Kinase Kinase Kinase 7</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase Kinase Kinase 7&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Reverse Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;JNK Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Enzyme&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP3K7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase Kinase Kinase 7&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Reverse Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;JNK Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP3K7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115330</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein Subunit Alpha-13</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein Subunit Alpha-13&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Heterotrimeric G Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Heterotrimeric G Protein Subunit&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNA13 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein Subunit Alpha-13&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Heterotrimeric G Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNA13 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26490</classIRI>
<classLabel>Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;dsRNA Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Stress Related Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Enzyme&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP4K4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;dsRNA Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Stress Related Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP4K4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40966</classIRI>
<classLabel>Serine/Threonine-Protein Kinase Chk2</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase Chk2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cancer Susceptibility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK3 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;FHA Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Survival&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of G1 Phase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHEK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase Chk2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cancer Susceptibility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK3 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;FHA Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Survival&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of G1 Phase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHEK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26612</classIRI>
<classLabel>Activin Receptor Type-1</classLabel>
<deletedAxiom>&apos;Activin Receptor Type-1&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Serine/Threonine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Activin Receptor Type-1&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26613</classIRI>
<classLabel>Serine/Threonine-Protein Kinase Receptor R3</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase Receptor R3&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Serine/Threonine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVRL1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase Receptor R3&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVRL1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33993</classIRI>
<classLabel>Histone-Lysine N-Methyltransferase 2D</classLabel>
<deletedAxiom>&apos;Histone-Lysine N-Methyltransferase 2D&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KMT2D Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone-Lysine N-Methyltransferase 2D&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KMT2D Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33991</classIRI>
<classLabel>MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1</classLabel>
<deletedAxiom>&apos;MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MKNK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MKNK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33985</classIRI>
<classLabel>Nuclear Mitotic Apparatus Protein 1</classLabel>
<deletedAxiom>&apos;Nuclear Mitotic Apparatus Protein 1&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitotic Spindle Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NUMA1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Nuclear Mitotic Apparatus Protein 1&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitotic Spindle Regulation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NUMA1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33988</classIRI>
<classLabel>Megakaryocyte-Associated Tyrosine-Protein Kinase</classLabel>
<deletedAxiom>&apos;Megakaryocyte-Associated Tyrosine-Protein Kinase&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Megakaryocyte Differentiation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MATK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Megakaryocyte-Associated Tyrosine-Protein Kinase&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Megakaryocyte Differentiation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MATK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33984</classIRI>
<classLabel>NT-3 Growth Factor Receptor</classLabel>
<deletedAxiom>&apos;NT-3 Growth Factor Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NTRK3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NT-3 Growth Factor Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NTRK3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33983</classIRI>
<classLabel>BDNF/NT-3 Growth Factors Receptor</classLabel>
<deletedAxiom>&apos;BDNF/NT-3 Growth Factors Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NTRK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;BDNF/NT-3 Growth Factors Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NTRK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33979</classIRI>
<classLabel>NADPH-Dependent Diflavin Oxidoreductase 1</classLabel>
<deletedAxiom>&apos;NADPH-Dependent Diflavin Oxidoreductase 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NDOR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NADPH-Dependent Diflavin Oxidoreductase 1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;</newAxiom>
<newAxiom>&apos;NADPH-Dependent Diflavin Oxidoreductase 1&apos; SubClassOf &apos;Oxidoreductase&apos;</newAxiom>
<newAxiom>&apos;NADPH-Dependent Diflavin Oxidoreductase 1&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NDOR1 Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33964</classIRI>
<classLabel>N-cym Protein</classLabel>
<deletedAxiom>&apos;N-cym Protein&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MYCNOS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;N-cym Protein&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MYCNOS Gene&apos;</newAxiom>
<newAxiom>&apos;N-cym Protein&apos; SubClassOf &apos;Regulatory Protein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33955</classIRI>
<classLabel>RAS-Related Protein MRAS</classLabel>
<deletedAxiom>&apos;RAS-Related Protein MRAS&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RAS Superfamily Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MRAS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAS-Related Protein MRAS&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MRAS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33912</classIRI>
<classLabel>DNA Replication Licensing Factor MCM7</classLabel>
<deletedAxiom>&apos;DNA Replication Licensing Factor MCM7&apos; EquivalentTo &apos;MCM Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Helicase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Replication Licensing Factor MCM7&apos; EquivalentTo &apos;DNA Helicase&apos; and &apos;Licensing Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;MCM Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33910</classIRI>
<classLabel>DNA Replication Licensing Factor MCM5</classLabel>
<deletedAxiom>&apos;DNA Replication Licensing Factor MCM5&apos; EquivalentTo &apos;MCM Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDK Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Replication Licensing Factor MCM5&apos; EquivalentTo &apos;Licensing Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDK Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Binding Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;MCM Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33911</classIRI>
<classLabel>DNA Replication Licensing Factor MCM6</classLabel>
<deletedAxiom>&apos;DNA Replication Licensing Factor MCM6&apos; EquivalentTo &apos;MCM Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Helicase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Replication Licensing Factor MCM6&apos; EquivalentTo &apos;DNA Helicase&apos; and &apos;Licensing Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;MCM Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33909</classIRI>
<classLabel>DNA Replication Licensing Factor MCM4</classLabel>
<deletedAxiom>&apos;DNA Replication Licensing Factor MCM4&apos; EquivalentTo &apos;MCM Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Helicase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Replication Licensing Factor MCM4&apos; EquivalentTo &apos;DNA Helicase&apos; and &apos;Licensing Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;MCM Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33908</classIRI>
<classLabel>Protein MCM10 Homolog</classLabel>
<deletedAxiom>&apos;Protein MCM10 Homolog&apos; EquivalentTo &apos;MCM Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;S Phase Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM10 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein MCM10 Homolog&apos; EquivalentTo &apos;DNA Replication Initiation Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Binding Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;MCM Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;S Phase Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM10 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96389</classIRI>
<classLabel>Receptor-Interacting Serine/Threonine-Protein Kinase 4</classLabel>
<deletedAxiom>&apos;Receptor-Interacting Serine/Threonine-Protein Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RIPK4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Interacting Serine/Threonine-Protein Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RIPK4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96343</classIRI>
<classLabel>Histone-Lysine N-Methyltransferase NSD3</classLabel>
<deletedAxiom>&apos;Histone-Lysine N-Methyltransferase NSD3&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysine Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PWWP Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SET Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WHSC1L1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone-Lysine N-Methyltransferase NSD3&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysine Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PWWP Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SET Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WHSC1L1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96339</classIRI>
<classLabel>Arachidonate 12-Lipoxygenase, 12R-Type</classLabel>
<deletedAxiom>&apos;Arachidonate 12-Lipoxygenase, 12R-Type&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL23-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skin&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;B-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Keratinocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Hair Follicle&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxygenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Leukotriene Production&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALOX12B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Arachidonate 12-Lipoxygenase, 12R-Type&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL23-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skin&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;B-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Keratinocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Hair Follicle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Leukotriene Production&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALOX12B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96336</classIRI>
<classLabel>Lysine-Specific Demethylase 6A</classLabel>
<deletedAxiom>&apos;Lysine-Specific Demethylase 6A&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96369</classIRI>
<classLabel>F-Box/WD Repeat-Containing Protein 1A</classLabel>
<deletedAxiom>&apos;F-Box/WD Repeat-Containing Protein 1A&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Circadian Rhythm Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Atypical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BTRC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;F-Box/WD Repeat-Containing Protein 1A&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Circadian Rhythm Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Atypical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;F-Box Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BTRC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96360</classIRI>
<classLabel>Exosome Complex Exonuclease RRP44</classLabel>
<deletedAxiom>&apos;Exosome Complex Exonuclease RRP44&apos; EquivalentTo &apos;Ribonuclease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Exonuclease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ribonuclease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DIS3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Exosome Complex Exonuclease RRP44&apos; EquivalentTo &apos;Ribonuclease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Exonuclease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DIS3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96462</classIRI>
<classLabel>Peroxisome Proliferator-Activated Receptor Delta</classLabel>
<deletedAxiom>&apos;Peroxisome Proliferator-Activated Receptor Delta&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPARD Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Peroxisome Proliferator-Activated Receptor Delta&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPARD Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96443</classIRI>
<classLabel>Peroxisomal Acyl-Coenzyme A Oxidase 2</classLabel>
<deletedAxiom>&apos;Peroxisomal Acyl-Coenzyme A Oxidase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Peroxisome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACOX2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Peroxisomal Acyl-Coenzyme A Oxidase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Peroxisome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACOX2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96440</classIRI>
<classLabel>Prostacyclin Synthase</classLabel>
<deletedAxiom>&apos;Prostacyclin Synthase&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Eicosanoid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Heme Protein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Prostaglandin Production&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTGIS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Prostacyclin Synthase&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Eicosanoid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Heme Protein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Prostaglandin Production&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTGIS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80083</classIRI>
<classLabel>Fetal Growth Retardation</classLabel>
<deletedAxiom>&apos;Fetal Growth Retardation&apos; SubClassOf &apos;Fetal Disorder&apos;</deletedAxiom>
<newAxiom>&apos;Fetal Growth Retardation&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18942</classIRI>
<classLabel>1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2</classLabel>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vibrio cholerae Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLCG2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vibrio cholerae Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLCG2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41050</classIRI>
<classLabel>Matrix Metalloproteinase-14</classLabel>
<deletedAxiom>&apos;Matrix Metalloproteinase-14&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Matrix Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP14 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Matrix Metalloproteinase-14&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP14 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41044</classIRI>
<classLabel>Interstitial Collagenase</classLabel>
<deletedAxiom>&apos;Interstitial Collagenase&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Matrix Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interstitial Collagenase&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Collagenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41046</classIRI>
<classLabel>Neutrophil Collagenase</classLabel>
<deletedAxiom>&apos;Neutrophil Collagenase&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Matrix Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Neutrophil Collagenase&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Collagenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41023</classIRI>
<classLabel>Tachykinin Receptor 1</classLabel>
<deletedAxiom>&apos;Tachykinin Receptor 1&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TACR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tachykinin Receptor 1&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TACR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41020</classIRI>
<classLabel>Histamine H2 Receptor</classLabel>
<deletedAxiom>&apos;Histamine H2 Receptor&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HRH2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histamine H2 Receptor&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HRH2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41038</classIRI>
<classLabel>Riboadenylate Transferase</classLabel>
<newAxiom>&apos;Riboadenylate Transferase&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Polyadenylation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114805</classIRI>
<classLabel>Arachidonate 15-Lipoxygenase B</classLabel>
<deletedAxiom>&apos;Arachidonate 15-Lipoxygenase B&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALOX15B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Arachidonate 15-Lipoxygenase B&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALOX15B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114690</classIRI>
<classLabel>1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Epsilon</classLabel>
<deletedAxiom>&apos;1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Epsilon&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Outer Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Acyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AGPAT5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Epsilon&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Outer Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AGPAT5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C27032</classIRI>
<classLabel>ALK Tyrosine Kinase Receptor</classLabel>
<deletedAxiom>&apos;ALK Tyrosine Kinase Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;ALK Kinase Overexpression&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nervous System Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;ALK Tyrosine Kinase Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;ALK Kinase Overexpression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nervous System Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114943</classIRI>
<classLabel>25-Hydroxycholesterol 7-Alpha-Hydroxylase</classLabel>
<deletedAxiom>&apos;25-Hydroxycholesterol 7-Alpha-Hydroxylase&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP7B1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;25-Hydroxycholesterol 7-Alpha-Hydroxylase&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP7B1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114359</classIRI>
<classLabel>MAP Kinase-Activated Protein Kinase 2</classLabel>
<deletedAxiom>&apos;MAP Kinase-Activated Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HSP27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK/MAPKAP Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPKAPK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;MAP Kinase-Activated Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HSP27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK/MAPKAP Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPKAPK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114350</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein G(o) Subunit Alpha</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein G(o) Subunit Alpha&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Heterotrimeric G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNAO1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein G(o) Subunit Alpha&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Heterotrimeric G Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G(i) Alpha&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNAO1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114393</classIRI>
<classLabel>MAP/Microtubule Affinity-Regulating Kinase 4</classLabel>
<deletedAxiom>&apos;MAP/Microtubule Affinity-Regulating Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tubulin Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Microtubule Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MARK4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;MAP/Microtubule Affinity-Regulating Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tubulin Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Microtubule Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MARK4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114578</classIRI>
<classLabel>Inositol 1,4,5-Trisphosphate Receptor Type 2</classLabel>
<deletedAxiom>&apos;Inositol 1,4,5-Trisphosphate Receptor Type 2&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transport Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ITPR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Inositol 1,4,5-Trisphosphate Receptor Type 2&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transport Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ITPR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114619</classIRI>
<classLabel>F-Box/LRR-Repeat Protein 18</classLabel>
<deletedAxiom>&apos;F-Box/LRR-Repeat Protein 18&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;F-Box Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FBXL18 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;F-Box/LRR-Repeat Protein 18&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;F-Box Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FBXL18 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114429</classIRI>
<classLabel>Solute Carrier Family 26 Member 6</classLabel>
<deletedAxiom>&apos;Solute Carrier Family 26 Member 6&apos; EquivalentTo &apos;Transport Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Solute Carrier Family&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transmembrane Transport&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;pH Homeostasis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ion Transport Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SLC26A6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Solute Carrier Family 26 Member 6&apos; EquivalentTo &apos;Transport Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Solute Carrier Family&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transmembrane Transport&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;pH Homeostasis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ion Transport Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SLC26A6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71450</classIRI>
<classLabel>Histone Acetyltransferase KAT6B</classLabel>
<deletedAxiom>&apos;Histone Acetyltransferase KAT6B&apos; EquivalentTo &apos;Histone Acetylase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Acetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Acetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KAT6B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Acetyltransferase KAT6B&apos; EquivalentTo &apos;Histone Acetylase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Acetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KAT6B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71456</classIRI>
<classLabel>Major Prion Protein</classLabel>
<deletedAxiom>&apos;Major Prion Protein&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Creutzfeldt-Jakob Disease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRNP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Major Prion Protein&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Creutzfeldt-Jakob Disease&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRNP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71449</classIRI>
<classLabel>Histone Acetyltransferase KAT6A</classLabel>
<deletedAxiom>&apos;Histone Acetyltransferase KAT6A&apos; EquivalentTo &apos;Histone Acetylase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleosome&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Acetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Acetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KAT6A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Acetyltransferase KAT6A&apos; EquivalentTo &apos;Histone Acetylase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleosome&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Acetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KAT6A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88190</classIRI>
<classLabel>Protein Phosphatase 1D</classLabel>
<deletedAxiom>&apos;Protein Phosphatase 1D&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPM1D Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein Phosphatase 1D&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPM1D Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95809</classIRI>
<classLabel>Carboxypeptidase E</classLabel>
<deletedAxiom>&apos;Carboxypeptidase E&apos; EquivalentTo &apos;CPE Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type I Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Trafficking Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Extracellular Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CPE Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Carboxypeptidase E&apos; EquivalentTo &apos;CPE Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type I Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Trafficking Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Extracellular Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CPE Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95810</classIRI>
<classLabel>Carboxypeptidase E-deltaN</classLabel>
<deletedAxiom>&apos;Carboxypeptidase E-deltaN&apos; EquivalentTo &apos;CPE Gene Product&apos; and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Protein Splicing Abnormality&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Protein Truncation Abnormality&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CPE Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Carboxypeptidase E-deltaN&apos; EquivalentTo &apos;CPE Gene Product&apos; and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Protein Splicing Abnormality&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Protein Truncation Abnormality&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CPE Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95864</classIRI>
<classLabel>Proteasome Activator Complex Subunit 3</classLabel>
<deletedAxiom>&apos;Proteasome Activator Complex Subunit 3&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Antigen Processing and Presentation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proteasome Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Proteasome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PSME3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Proteasome Activator Complex Subunit 3&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Antigen Processing and Presentation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proteasome Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Proteasome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PSME3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95874</classIRI>
<classLabel>Lysyl Oxidase Homolog 2</classLabel>
<deletedAxiom>&apos;Lysyl Oxidase Homolog 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Extracellular Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Scavenger Receptor Cysteine-Rich Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Aging&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LOXL2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Lysyl Oxidase Homolog 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Extracellular Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Scavenger Receptor Cysteine-Rich Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Aging&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LOXL2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95849</classIRI>
<classLabel>NEDD8</classLabel>
<deletedAxiom>&apos;NEDD8&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NEDD8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NEDD8&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NEDD8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95843</classIRI>
<classLabel>Ubiquitin Conjugation Factor E4 B</classLabel>
<deletedAxiom>&apos;Ubiquitin Conjugation Factor E4 B&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBE4B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ubiquitin Conjugation Factor E4 B&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBE4B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95858</classIRI>
<classLabel>NEDD8-Activating Enzyme E1 Catalytic Subunit</classLabel>
<deletedAxiom>&apos;NEDD8-Activating Enzyme E1 Catalytic Subunit&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;NEDD8 Activating Enzyme&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBA3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NEDD8-Activating Enzyme E1 Catalytic Subunit&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;NEDD8 Activating Enzyme&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBA3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95852</classIRI>
<classLabel>N-Alpha-Acetyltransferase 10, NatA Catalytic Subunit</classLabel>
<deletedAxiom>&apos;N-Alpha-Acetyltransferase 10, NatA Catalytic Subunit&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia and Oxygen Homeostasis Regulation of HIF-1-Alpha Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Acyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Acetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NAA10 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;N-Alpha-Acetyltransferase 10, NatA Catalytic Subunit&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia and Oxygen Homeostasis Regulation of HIF-1-Alpha Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Acetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NAA10 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95855</classIRI>
<classLabel>NEDD8-Activating Enzyme E1 Regulatory Subunit</classLabel>
<deletedAxiom>&apos;NEDD8-Activating Enzyme E1 Regulatory Subunit&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;NEDD8 Activating Enzyme&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NAE1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NEDD8-Activating Enzyme E1 Regulatory Subunit&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;NEDD8 Activating Enzyme&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NAE1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95927</classIRI>
<classLabel>Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit A</classLabel>
<deletedAxiom>&apos;Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit A&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Paroxysmal Nocturnal Hemoglobinuria&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Glycosylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIGA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit A&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Paroxysmal Nocturnal Hemoglobinuria&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Glycosylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIGA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88359</classIRI>
<classLabel>Cystatin-C</classLabel>
<deletedAxiom>&apos;Cystatin-C&apos; EquivalentTo &apos;Enzyme Inhibitor Protein&apos; and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Amyloidosis&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Age-Related Macular Degeneration&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Enzyme Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Enzyme Inhibition&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Degradation Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CST3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cystatin-C&apos; EquivalentTo &apos;Enzyme Inhibitor Protein&apos; and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Amyloidosis&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Age-Related Macular Degeneration&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Enzyme Inhibition&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Degradation Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CST3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88293</classIRI>
<classLabel>JAK2 Inhibitor TG101348</classLabel>
<deletedAxiom>&apos;JAK2 Inhibitor TG101348&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;JAK2 Inhibitor TG101348&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125450</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95254</classIRI>
<classLabel>Methylcytosine Dioxygenase TET2</classLabel>
<deletedAxiom>&apos;Methylcytosine Dioxygenase TET2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Polycythemia Vera&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Proline-Rich Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Myelopoiesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TET2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Methylcytosine Dioxygenase TET2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Polycythemia Vera&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Proline-Rich Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Myelopoiesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TET2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95258</classIRI>
<classLabel>Serine/Threonine-Protein Kinase D1</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase D1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Kinase C&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKD1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase D1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Kinase C&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKD1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95270</classIRI>
<classLabel>Fumarate Hydratase, Mitochondrial</classLabel>
<deletedAxiom>&apos;Fumarate Hydratase, Mitochondrial&apos; EquivalentTo &apos;Lyase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Citrate Cycle (TCA Cycle) Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;The Citric Acid Cycle&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hereditary Leiomyomatosis and Renal Cell Cancer&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Lyase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Respiration&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FH Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fumarate Hydratase, Mitochondrial&apos; EquivalentTo &apos;Lyase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Citrate Cycle (TCA Cycle) Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;The Citric Acid Cycle&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hereditary Leiomyomatosis and Renal Cell Cancer&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Respiration&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FH Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95261</classIRI>
<classLabel>Serine/Threonine-Protein Kinase D2</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase D2&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95264</classIRI>
<classLabel>Serine/Threonine-Protein Kinase D3</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase D3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Kinase C&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKD3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase D3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Kinase C&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKD3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95267</classIRI>
<classLabel>Aurora Kinase C</classLabel>
<deletedAxiom>&apos;Aurora Kinase C&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora B Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora C Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokinesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AURKC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Aurora Kinase C&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora B Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora C Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokinesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AURKC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95299</classIRI>
<classLabel>Cyclin-Dependent Kinase 8</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 8&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Mediator Complex&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 8&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Mediator Complex&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88996</classIRI>
<classLabel>Small Nucleolar RNA SNORA74A (U19)</classLabel>
<deletedAxiom>&apos;Small Nucleolar RNA SNORA74A (U19)&apos; SubClassOf &apos;Small Nuclear RNA&apos;</deletedAxiom>
<newAxiom>&apos;Small Nucleolar RNA SNORA74A (U19)&apos; SubClassOf &apos;Small Nucleolar RNA&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95113</classIRI>
<classLabel>Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1</classLabel>
<deletedAxiom>&apos;Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1&apos; EquivalentTo &apos;INPP5D Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;INPP5D Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1&apos; EquivalentTo &apos;INPP5D Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;INPP5D Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95702</classIRI>
<classLabel>JAK2 Inhibitor BMS-911543</classLabel>
<deletedAxiom>&apos;JAK2 Inhibitor BMS-911543&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;JAK2 Inhibitor BMS-911543&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125450</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95414</classIRI>
<classLabel>Low-Density Lipoprotein Receptor-Related Protein 5</classLabel>
<deletedAxiom>&apos;Low-Density Lipoprotein Receptor-Related Protein 5&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Mediated Endocytosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LRP5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Low-Density Lipoprotein Receptor-Related Protein 5&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Mediated Endocytosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LRP5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95415</classIRI>
<classLabel>Low-Density Lipoprotein Receptor-Related Protein 6</classLabel>
<deletedAxiom>&apos;Low-Density Lipoprotein Receptor-Related Protein 6&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Segmentation Clock Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt/LRP6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Mediated Endocytosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LRP6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Low-Density Lipoprotein Receptor-Related Protein 6&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Segmentation Clock Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt/LRP6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Mediated Endocytosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LRP6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95409</classIRI>
<classLabel>Plasma Kallikrein</classLabel>
<deletedAxiom>&apos;Plasma Kallikrein&apos; EquivalentTo &apos;Kallikrein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KLKB1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Plasma Kallikrein&apos; EquivalentTo &apos;Kallikrein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KLKB1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95469</classIRI>
<classLabel>cGMP-Specific 3&apos;,5&apos;-Cyclic Phosphodiesterase</classLabel>
<deletedAxiom>&apos;cGMP-Specific 3&apos;,5&apos;-Cyclic Phosphodiesterase&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Esterase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDE5A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;cGMP-Specific 3&apos;,5&apos;-Cyclic Phosphodiesterase&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDE5A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95463</classIRI>
<classLabel>AH Receptor-Interacting Protein</classLabel>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Growth Hormone-Producing Pituitary Gland Adenoma&apos;</deletedAxiom>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Signaling Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AHR Signal Transduction Pathway&apos;</deletedAxiom>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Gene_Product_Has_Abnormality&apos; some &apos;Disease-causing Mutation&apos;</deletedAxiom>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;ACTH-Producing Pituitary Gland Adenoma&apos;</deletedAxiom>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;</deletedAxiom>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AIP Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;</deletedAxiom>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;</deletedAxiom>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Prolactin-Producing Pituitary Gland Adenoma&apos;</deletedAxiom>
<deletedAxiom>&apos;AH Receptor-Interacting Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;</deletedAxiom>
<newAxiom>&apos;AH Receptor-Interacting Protein&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AHR Signal Transduction Pathway&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Disease-causing Mutation&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Prolactin-Producing Pituitary Gland Adenoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Growth Hormone-Producing Pituitary Gland Adenoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;ACTH-Producing Pituitary Gland Adenoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AIP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95588</classIRI>
<classLabel>CUB Domain-Containing Protein 1</classLabel>
<deletedAxiom>&apos;CUB Domain-Containing Protein 1&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95591</classIRI>
<classLabel>NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial</classLabel>
<deletedAxiom>&apos;NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial&apos; EquivalentTo &apos;Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class III Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrial Matrix&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Deacetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deacetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SIRT3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial&apos; EquivalentTo &apos;Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class III Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrial Matrix&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deacetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SIRT3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95594</classIRI>
<classLabel>Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 Beta</classLabel>
<deletedAxiom>&apos;Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 Beta&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitotic/Spindle Checkpoint&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BUB1B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 Beta&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitotic/Spindle Checkpoint&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BUB1B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95569</classIRI>
<classLabel>Uroporphyrinogen Decarboxylase</classLabel>
<deletedAxiom>&apos;Uroporphyrinogen Decarboxylase&apos; EquivalentTo &apos;Lyase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Porphyrin and Chlorophyll Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hemoglobin Chaperone Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Porphyria Cutanea Tarda&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hepatoerythropoietic Porphyria&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Lyase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UROD Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Uroporphyrinogen Decarboxylase&apos; EquivalentTo &apos;Lyase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Porphyrin and Chlorophyll Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hemoglobin Chaperone Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Porphyria Cutanea Tarda&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hepatoerythropoietic Porphyria&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UROD Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95564</classIRI>
<classLabel>NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2</classLabel>
<deletedAxiom>&apos;NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WWP2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WWP2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95574</classIRI>
<classLabel>cAMP-Specific 3&apos;,5&apos;-Cyclic Phosphodiesterase 4B</classLabel>
<deletedAxiom>&apos;cAMP-Specific 3&apos;,5&apos;-Cyclic Phosphodiesterase 4B&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Esterase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDE4B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;cAMP-Specific 3&apos;,5&apos;-Cyclic Phosphodiesterase 4B&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDE4B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77217</classIRI>
<classLabel>Isocitrate Dehydrogenase [NADP] Cytoplasmic</classLabel>
<deletedAxiom>&apos;Isocitrate Dehydrogenase [NADP] Cytoplasmic&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Citrate Cycle (TCA Cycle) Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Glioblastoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IDH1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Isocitrate Dehydrogenase [NADP] Cytoplasmic&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Citrate Cycle (TCA Cycle) Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Glioblastoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IDH1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77211</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase CHFR</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase CHFR&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHFR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase CHFR&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHFR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C120059</classIRI>
<classLabel>Lysine-Specific Demethylase 2B</classLabel>
<deletedAxiom>&apos;Lysine-Specific Demethylase 2B&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;F-Box Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KDM2B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Lysine-Specific Demethylase 2B&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;F-Box Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KDM2B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42594</classIRI>
<classLabel>Serine/Threonine-Protein Kinase PAK 1</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase PAK 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase PAK 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42621</classIRI>
<classLabel>Glycogen Synthase Kinase-3 Alpha</classLabel>
<deletedAxiom>&apos;Glycogen Synthase Kinase-3 Alpha&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphoinositide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GSK3A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Glycogen Synthase Kinase-3 Alpha&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphoinositide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GSK3A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42733</classIRI>
<classLabel>Protein Kinase C Beta Type</classLabel>
<deletedAxiom>&apos;Protein Kinase C Beta Type&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channel and Phorbal Esters Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vibrio cholerae Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Downstream Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;JNK Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase C&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKCB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein Kinase C Beta Type&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channel and Phorbal Esters Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vibrio cholerae Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Downstream Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;JNK Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase C&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKCB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54701</classIRI>
<classLabel>3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase</classLabel>
<deletedAxiom>&apos;3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sterol Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HMGCR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sterol Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HMGCR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65916</classIRI>
<classLabel>Indoramin</classLabel>
<deletedAxiom>&apos;Indoramin&apos; SubClassOf &apos;Beta-Adrenergic Antagonist&apos;</deletedAxiom>
<newAxiom>&apos;Indoramin&apos; SubClassOf &apos;Alpha-Adrenergic Antagonist&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70618</classIRI>
<classLabel>Complement Component-4</classLabel>
<deletedAxiom>&apos;Complement Component-4&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Complement Component Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48836</classIRI>
<classLabel>78 kDa Glucose-Regulated Protein</classLabel>
<deletedAxiom>&apos;78 kDa Glucose-Regulated Protein&apos; EquivalentTo &apos;Chaperone&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Export Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Antigen Processing and Presentation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chaperone&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Stress-Induced Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HSPA5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;78 kDa Glucose-Regulated Protein&apos; EquivalentTo &apos;Chaperone&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Export Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Antigen Processing and Presentation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Stress-Induced Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HSPA5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48211</classIRI>
<classLabel>Alpha-Methylacyl-CoA Racemase</classLabel>
<deletedAxiom>&apos;Alpha-Methylacyl-CoA Racemase&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Peroxisome&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Isomerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AMACR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Alpha-Methylacyl-CoA Racemase&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Peroxisome&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AMACR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48216</classIRI>
<classLabel>Disintegrin and Metalloproteinase Domain-Containing Protein 17</classLabel>
<deletedAxiom>&apos;Disintegrin and Metalloproteinase Domain-Containing Protein 17&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gamma-Secretase Mediated ErbB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Segmentation Clock Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch and Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Metalloprotein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;ADAM Family Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Disintegrin Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADAM Type Metalloprotease Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAM17 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Disintegrin and Metalloproteinase Domain-Containing Protein 17&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gamma-Secretase Mediated ErbB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Segmentation Clock Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch and Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Metalloprotein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;ADAM Family Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Disintegrin Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADAM Type Metalloprotease Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAM17 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C89719</classIRI>
<classLabel>Guanine Nucleotide-Binding Protein Subunit Alpha-11</classLabel>
<deletedAxiom>&apos;Guanine Nucleotide-Binding Protein Subunit Alpha-11&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Heterotrimeric G Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Heterotrimeric G Protein Subunit&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNA11 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Guanine Nucleotide-Binding Protein Subunit Alpha-11&apos; EquivalentTo &apos;Heterotrimeric G Protein Subunit&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Heterotrimeric G Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GNA11 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C89768</classIRI>
<classLabel>CDK-Activating Kinase Assembly Factor MAT1</classLabel>
<deletedAxiom>&apos;CDK-Activating Kinase Assembly Factor MAT1&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and &apos;Basal Transcription Factor&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;TFIIH&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MNAT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;CDK-Activating Kinase Assembly Factor MAT1&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and &apos;Basal Transcription Factor&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;TFIIH&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MNAT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C89769</classIRI>
<classLabel>Cyclin-Dependent Kinase 7</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 7&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and &apos;Basal Transcription Factor&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;TFIIH&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Kinase Protein Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 7&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and &apos;Basal Transcription Factor&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;TFIIH&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Kinase Protein Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C89770</classIRI>
<classLabel>Cyclin-H</classLabel>
<deletedAxiom>&apos;Cyclin-H&apos; EquivalentTo &apos;Cyclin&apos; and &apos;Basal Transcription Factor&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;TFIIH&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNH Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-H&apos; EquivalentTo &apos;Cyclin&apos; and &apos;Basal Transcription Factor&apos; and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;TFIIH&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNH Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C55287</classIRI>
<classLabel>Superoxide Dismutase [Cu-Zn]</classLabel>
<deletedAxiom>&apos;Superoxide Dismutase [Cu-Zn]&apos; EquivalentTo &apos;Superoxide Dismutase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Flumazenil Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Free Radical Induced Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Longevity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SOD1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Superoxide Dismutase [Cu-Zn]&apos; EquivalentTo &apos;Superoxide Dismutase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Flumazenil Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Free Radical Induced Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Longevity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SOD1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C117251</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase HERC2</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase HERC2&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centriole&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HERC2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase HERC2&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centriole&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HERC2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94661</classIRI>
<classLabel>Aminopeptidase N</classLabel>
<deletedAxiom>&apos;Aminopeptidase N&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glutathione Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renin-Angiotensin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ANPEP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Aminopeptidase N&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glutathione Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renin-Angiotensin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ANPEP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94751</classIRI>
<classLabel>Serine/Threonine-Protein Kinase 33</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase 33&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94755</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase TRIM21</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase TRIM21&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Systemic Lupus Erythematosus Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;TRIM Motif&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIM21 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase TRIM21&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Systemic Lupus Erythematosus Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;TRIM Motif&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIM21 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94790</classIRI>
<classLabel>Tumor Necrosis Factor Receptor Superfamily Member 4</classLabel>
<deletedAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 4&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;OX40 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Downstream Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 4&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;OX40 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Downstream Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94707</classIRI>
<classLabel>5&apos;-3&apos; Exoribonuclease 1</classLabel>
<deletedAxiom>&apos;5&apos;-3&apos; Exoribonuclease 1&apos; EquivalentTo &apos;Ribonuclease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Exonuclease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ribonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tubulin Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;XRN1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;5&apos;-3&apos; Exoribonuclease 1&apos; EquivalentTo &apos;Ribonuclease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Exonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tubulin Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;XRN1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94747</classIRI>
<classLabel>5&apos;-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2</classLabel>
<deletedAxiom>&apos;5&apos;-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Resistance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Autophagy Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypertrophic Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;5&apos;-AMP-Activated Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKAA2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;5&apos;-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Resistance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Autophagy Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypertrophic Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;5&apos;-AMP-Activated Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKAA2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94710</classIRI>
<classLabel>5&apos;-3&apos; Exoribonuclease 2</classLabel>
<deletedAxiom>&apos;5&apos;-3&apos; Exoribonuclease 2&apos; EquivalentTo &apos;Ribonuclease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Exonuclease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ribonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription Termination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;XRN2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;5&apos;-3&apos; Exoribonuclease 2&apos; EquivalentTo &apos;Ribonuclease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Exonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription Termination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;XRN2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94724</classIRI>
<classLabel>DNA-3-Methyladenine Glycosylase</classLabel>
<deletedAxiom>&apos;DNA-3-Methyladenine Glycosylase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Base Excision Repair Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Repair Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Depurination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MPG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA-3-Methyladenine Glycosylase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Base Excision Repair Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Repair Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Depurination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MPG Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C117073</classIRI>
<classLabel>Tumor Necrosis Factor Receptor Superfamily Member 12A</classLabel>
<deletedAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 12A&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Induction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Angiogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF12A Gene&apos;)</deletedAxiom>
<deletedAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 12A&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Angiogenesis Promoter&apos;</deletedAxiom>
<newAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 12A&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Angiogenesis Promoter&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Induction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Angiogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF12A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C117093</classIRI>
<classLabel>DNA Replication ATP-Dependent Helicase/Nuclease DNA2</classLabel>
<deletedAxiom>&apos;DNA Replication ATP-Dependent Helicase/Nuclease DNA2&apos; SubClassOf &apos;DNA Helicase&apos;</deletedAxiom>
<deletedAxiom>&apos;DNA Replication ATP-Dependent Helicase/Nuclease DNA2&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DNA Replication Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Repair Endonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNA2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Replication ATP-Dependent Helicase/Nuclease DNA2&apos; EquivalentTo &apos;DNA Helicase&apos; and &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DNA Replication Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Repair Endonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNA2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94809</classIRI>
<classLabel>Follicle-Stimulating Hormone Receptor</classLabel>
<deletedAxiom>&apos;Follicle-Stimulating Hormone Receptor&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Spermatogenesis Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Gonadal Dysgenesis&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Spermatogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FSHR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Follicle-Stimulating Hormone Receptor&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Spermatogenesis Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Gonadal Dysgenesis&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Spermatogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FSHR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82854</classIRI>
<classLabel>Prothrombin</classLabel>
<deletedAxiom>&apos;Prothrombin&apos; EquivalentTo &apos;F2 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DBPB Transcriptional Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fibrinolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA2 and FOXA3 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Cerebrovascular Accident&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Kringle Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Coagulation Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;F2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Prothrombin&apos; EquivalentTo &apos;F2 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DBPB Transcriptional Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fibrinolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA2 and FOXA3 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Cerebrovascular Accident&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Kringle Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;F2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82857</classIRI>
<classLabel>Mono-ADP-Ribosyltransferase Sirtuin-6</classLabel>
<deletedAxiom>&apos;Mono-ADP-Ribosyltransferase Sirtuin-6&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82861</classIRI>
<classLabel>Fatty Acid Desaturase 1</classLabel>
<deletedAxiom>&apos;Fatty Acid Desaturase 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FADS1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fatty Acid Desaturase 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FADS1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82876</classIRI>
<classLabel>Short-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial</classLabel>
<deletedAxiom>&apos;Short-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACADS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Short-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACADS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82877</classIRI>
<classLabel>Medium-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial</classLabel>
<deletedAxiom>&apos;Medium-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACADM Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Medium-Chain Specific Acyl-CoA Dehydrogenase, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACADM Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78153</classIRI>
<classLabel>Atypical Chemokine Receptor 1</classLabel>
<deletedAxiom>&apos;Atypical Chemokine Receptor 1&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chemokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACKR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Atypical Chemokine Receptor 1&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACKR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78156</classIRI>
<classLabel>Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2</classLabel>
<deletedAxiom>&apos;Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Parkinson&apos;s Disease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LRRK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Parkinson&apos;s Disease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LRRK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43318</classIRI>
<classLabel>Heme Oxygenase 1</classLabel>
<deletedAxiom>&apos;Heme Oxygenase 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Porphyrin and Chlorophyll Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL10 Anti-inflammatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Squamous Cell Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Catabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HMOX1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Heme Oxygenase 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Porphyrin and Chlorophyll Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL10 Anti-inflammatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Squamous Cell Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Catabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HMOX1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43297</classIRI>
<classLabel>Kallikrein-11</classLabel>
<deletedAxiom>&apos;Kallikrein-11&apos; EquivalentTo &apos;Kallikrein&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Factor&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skin&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Kallikrein&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KLK11 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Kallikrein-11&apos; EquivalentTo &apos;Kallikrein&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Factor&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skin&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KLK11 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43241</classIRI>
<classLabel>Purine Nucleoside Phosphorylase</classLabel>
<deletedAxiom>&apos;Purine Nucleoside Phosphorylase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nicotinate and Nicotinamide Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PNP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Purine Nucleoside Phosphorylase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nicotinate and Nicotinamide Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PNP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43238</classIRI>
<classLabel>Wiskott-Aldrich Syndrome Protein</classLabel>
<deletedAxiom>&apos;Wiskott-Aldrich Syndrome Protein&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WAS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Wiskott-Aldrich Syndrome Protein&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WAS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13408</classIRI>
<classLabel>Lysine-Specific Demethylase 5B</classLabel>
<deletedAxiom>&apos;Lysine-Specific Demethylase 5B&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ARID Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Repressor/Corepressor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KDM5B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Lysine-Specific Demethylase 5B&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ARID Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Repressor/Corepressor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KDM5B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116951</classIRI>
<classLabel>Leukotriene A-4 Hydrolase</classLabel>
<deletedAxiom>&apos;Leukotriene A-4 Hydrolase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Peptide Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Eicosanoid Modulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LTA4H Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Leukotriene A-4 Hydrolase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Peptide Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Eicosanoid Modulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LTA4H Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78837</classIRI>
<classLabel>Pacritinib</classLabel>
<deletedAxiom>&apos;Pacritinib&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;Pacritinib&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125450</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116861</classIRI>
<classLabel>Pan-RAF Inhibitor LY3009120</classLabel>
<deletedAxiom>&apos;Pan-RAF Inhibitor LY3009120&apos; SubClassOf &apos;Serine/Threonine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;Pan-RAF Inhibitor LY3009120&apos; SubClassOf &apos;Raf Kinase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25919</classIRI>
<classLabel>Serine/Threonine-Protein Kinase Chk1</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase Chk1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cancer Susceptibility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDC25 and CHK1 Regulatory Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Circadian Rhythm Pathway PID&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Small Intestine&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHEK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase Chk1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cancer Susceptibility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDC25 and CHK1 Regulatory Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Circadian Rhythm Pathway PID&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Small Intestine&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHEK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25856</classIRI>
<classLabel>Dual Specificity Protein Phosphatase 3</classLabel>
<deletedAxiom>&apos;Dual Specificity Protein Phosphatase 3&apos; EquivalentTo &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Dual-Specificity Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DUSP3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dual Specificity Protein Phosphatase 3&apos; EquivalentTo &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DUSP3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25859</classIRI>
<classLabel>Fibroblast Growth Factor Receptor 4</classLabel>
<deletedAxiom>&apos;Fibroblast Growth Factor Receptor 4&apos; EquivalentTo &apos;Fibroblast Growth Factor Receptor Family&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGFR4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fibroblast Growth Factor Receptor 4&apos; EquivalentTo &apos;Fibroblast Growth Factor Receptor Family&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGFR4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25858</classIRI>
<classLabel>Cyclin-Dependent Kinase 2-Associated Protein 1</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 2-Associated Protein 1&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Malignant Oral Neoplasm&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK2AP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 2-Associated Protein 1&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Malignant Oral Neoplasm&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK2AP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25855</classIRI>
<classLabel>Epithelial Discoidin Domain-Containing Receptor 1</classLabel>
<deletedAxiom>&apos;Epithelial Discoidin Domain-Containing Receptor 1&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ptc1 Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Esophageal Neoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Ovarian Neoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Childhood Brain Neoplasm&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Digestive System&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Epithelium&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Epithelial Discoidin Domain-Containing Receptor 1&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ptc1 Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Esophageal Neoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Ovarian Neoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Childhood Brain Neoplasm&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Digestive System&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Epithelium&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25841</classIRI>
<classLabel>Cyclin-Dependent Kinase 10</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 10&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK10 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 10&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK10 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25842</classIRI>
<classLabel>Cyclin-Dependent Kinase 2</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 2&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin E Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDK Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F1 Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 2&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin E Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDK Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F1 Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25879</classIRI>
<classLabel>Cyclin-Dependent Kinase Inhibitor 3</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase Inhibitor 3&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hepatocellular Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Dual-Specificity Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase Inhibitor 3&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hepatocellular Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25878</classIRI>
<classLabel>Cyclin-Dependent Kinase 4 Inhibitor C</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 4 Inhibitor C&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN2C Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 4 Inhibitor C&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN2C Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25874</classIRI>
<classLabel>Cyclin-Dependent Kinase-Like 2</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase-Like 2&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKL2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase-Like 2&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKL2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25865</classIRI>
<classLabel>Cyclin-Dependent Kinase 3</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 3&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 3&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25803</classIRI>
<classLabel>Hsp90 Co-Chaperone CDC37</classLabel>
<deletedAxiom>&apos;Hsp90 Co-Chaperone CDC37&apos; EquivalentTo &apos;Chaperone&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chaperone&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDC37 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Hsp90 Co-Chaperone CDC37&apos; EquivalentTo &apos;Chaperone&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDC37 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25801</classIRI>
<classLabel>Cyclin-Dependent Kinase 11B</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 11B&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Neuroblastoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK11B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 11B&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Neuroblastoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK11B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25880</classIRI>
<classLabel>Dual-Specificity Phosphoprotein Phosphatase</classLabel>
<deletedAxiom>&apos;Dual-Specificity Phosphoprotein Phosphatase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30016</classIRI>
<classLabel>Deoxyhypusine Synthase</classLabel>
<deletedAxiom>&apos;Deoxyhypusine Synthase&apos; EquivalentTo &apos;Alkyltransferase and Aryltransferase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Amino Acid Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DHPS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Deoxyhypusine Synthase&apos; EquivalentTo &apos;Alkyltransferase and Aryltransferase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Amino Acid Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DHPS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30006</classIRI>
<classLabel>Aurora Kinase A</classLabel>
<deletedAxiom>&apos;Aurora Kinase A&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitotic Spindle Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora B Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Anaphase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Telophase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AURKA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Aurora Kinase A&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitotic Spindle Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora B Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Anaphase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Telophase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AURKA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116093</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase TRIM23</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase TRIM23&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Lysosome&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;GTP Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Communication Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIM23 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase TRIM23&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Lysosome&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;GTP Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Communication Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIM23 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116033</classIRI>
<classLabel>5&apos;-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1</classLabel>
<deletedAxiom>&apos;5&apos;-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Circadian Rhythm Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Resistance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Autophagy Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypertrophic Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;5&apos;-AMP-Activated Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKAA1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;5&apos;-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Circadian Rhythm Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Resistance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Autophagy Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypertrophic Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;5&apos;-AMP-Activated Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKAA1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25773</classIRI>
<classLabel>G2/Mitotic-Specific Cyclin-B2</classLabel>
<deletedAxiom>&apos;G2/Mitotic-Specific Cyclin-B2&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EFP Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Golgi Apparatus&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;M-Phase Promoting Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitotic/Spindle Checkpoint&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNB2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G2/Mitotic-Specific Cyclin-B2&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EFP Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Golgi Apparatus&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;M-Phase Promoting Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitotic/Spindle Checkpoint&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNB2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25776</classIRI>
<classLabel>C-C Chemokine Receptor Type 1</classLabel>
<deletedAxiom>&apos;C-C Chemokine Receptor Type 1&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Polarization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Inflammation&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chemokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chemotactic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;C-C Chemokine Receptor Type 1&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Polarization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Inflammation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chemotactic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116307</classIRI>
<classLabel>Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Enzyme&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Necrosis Factor Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP4K3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Necrosis Factor Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP4K3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116274</classIRI>
<classLabel>1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3</classLabel>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLCD3 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Phospholipase&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;</deletedAxiom>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EF-Hand Domain&apos;</deletedAxiom>
<newAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EF-Hand Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLCD3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116579</classIRI>
<classLabel>Alpha-1-Antichymotrypsin</classLabel>
<deletedAxiom>&apos;Alpha-1-Antichymotrypsin&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Enzyme Inhibitor Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2946</classIRI>
<classLabel>Chondrosarcoma</classLabel>
<deletedAxiom>&apos;Chondrosarcoma&apos; EquivalentTo &apos;Chondrogenic Neoplasm&apos; and &apos;Infrequent Neoplasm&apos; and &apos;Sarcoma&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Chondrocyte&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Chondrocyte&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Hyaline Cartilage Differentiation&apos;)</deletedAxiom>
<newAxiom>&apos;Chondrosarcoma&apos; EquivalentTo &apos;Chondrogenic Neoplasm&apos; and &apos;Sarcoma&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Chondrocyte&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Chondrocyte&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Hyaline Cartilage Differentiation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30100</classIRI>
<classLabel>Tyrosine-Protein Kinase Receptor Tie-1</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Receptor Tie-1&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TIE1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Receptor Tie-1&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TIE1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30119</classIRI>
<classLabel>Serine/Threonine-Protein Kinase PAK 6</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase PAK 6&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAK6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase PAK 6&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAK6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30110</classIRI>
<classLabel>Transmembrane Protease Serine 2</classLabel>
<deletedAxiom>&apos;Transmembrane Protease Serine 2&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TMPRSS2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Transmembrane Protease Serine 2&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TMPRSS2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30111</classIRI>
<classLabel>Tumor Necrosis Factor Receptor Superfamily Member 11B</classLabel>
<deletedAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 11B&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF11B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 11B&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF11B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30127</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase RNF139</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase RNF139&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNF139 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase RNF139&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNF139 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30138</classIRI>
<classLabel>Nicotinamide Phosphoribosyltransferase</classLabel>
<deletedAxiom>&apos;Nicotinamide Phosphoribosyltransferase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and &apos;Cytokine&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nicotinate and Nicotinamide Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NAMPT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Nicotinamide Phosphoribosyltransferase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and &apos;Cytokine&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nicotinate and Nicotinamide Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NAMPT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30148</classIRI>
<classLabel>Tyrosine-Protein Kinase Receptor TYRO3</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Receptor TYRO3&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYRO3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Receptor TYRO3&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYRO3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30147</classIRI>
<classLabel>Dual Specificity Protein Kinase TTK</classLabel>
<deletedAxiom>&apos;Dual Specificity Protein Kinase TTK&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and &apos;Threonine/Tyrosine Protein Kinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TTK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dual Specificity Protein Kinase TTK&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and &apos;Threonine/Tyrosine Protein Kinase&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Segregation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TTK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25293</classIRI>
<classLabel>SGPT (ALT)</classLabel>
<deletedAxiom>&apos;SGPT (ALT)&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25202</classIRI>
<classLabel>SGOT (AST)</classLabel>
<deletedAxiom>&apos;SGOT (AST)&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30086</classIRI>
<classLabel>Myosin Light Chain Kinase, Smooth Muscle</classLabel>
<deletedAxiom>&apos;Myosin Light Chain Kinase, Smooth Muscle&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rho Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Muscle Contraction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MYLK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Myosin Light Chain Kinase, Smooth Muscle&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rho Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Muscle Contraction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MYLK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30075</classIRI>
<classLabel>Metallothionein-3</classLabel>
<deletedAxiom>&apos;Metallothionein-3&apos; EquivalentTo &apos;Metallothionein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Alzheimer&apos;s Disease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metallothionein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nerve Cell Survival&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MT3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Metallothionein-3&apos; EquivalentTo &apos;Metallothionein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Alzheimer&apos;s Disease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nerve Cell Survival&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MT3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30099</classIRI>
<classLabel>Transforming Growth Factor Beta Receptor Type 3</classLabel>
<deletedAxiom>&apos;Transforming Growth Factor Beta Receptor Type 3&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Serine/Threonine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TGFBR3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Transforming Growth Factor Beta Receptor Type 3&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TGFBR3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30098</classIRI>
<classLabel>TGF-Beta Receptor Type-1</classLabel>
<deletedAxiom>&apos;TGF-Beta Receptor Type-1&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Serine/Threonine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TGFBR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;TGF-Beta Receptor Type-1&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TGFBR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116671</classIRI>
<classLabel>Calcium/Calmodulin-Dependent Protein Kinase Type 1</classLabel>
<deletedAxiom>&apos;Calcium/Calmodulin-Dependent Protein Kinase Type 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Cell Differentiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CAMK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Calcium/Calmodulin-Dependent Protein Kinase Type 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Cell Differentiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CAMK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30160</classIRI>
<classLabel>Cyclin-Dependent Kinase 16</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 16&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK16 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 16&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK16 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30163</classIRI>
<classLabel>Platelet-Derived Growth Factor Receptor Alpha</classLabel>
<deletedAxiom>&apos;Platelet-Derived Growth Factor Receptor Alpha&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDGFRA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Platelet-Derived Growth Factor Receptor Alpha&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDGFRA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30164</classIRI>
<classLabel>Platelet-Derived Growth Factor Receptor Beta</classLabel>
<deletedAxiom>&apos;Platelet-Derived Growth Factor Receptor Beta&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Chronic Myelogenous Leukemia, BCR-ABL1 Positive&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDGFRB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Platelet-Derived Growth Factor Receptor Beta&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Chronic Myelogenous Leukemia, BCR-ABL1 Positive&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDGFRB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30166</classIRI>
<classLabel>3-Phosphoinositide-Dependent Protein Kinase 1</classLabel>
<deletedAxiom>&apos;3-Phosphoinositide-Dependent Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Corticosteroid Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Muscle Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Longevity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphoinositide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Trka Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDPK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;3-Phosphoinositide-Dependent Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Corticosteroid Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Muscle Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Longevity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphoinositide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Trka Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDPK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30150</classIRI>
<classLabel>Ubiquitin-Conjugating Enzyme E2 D2</classLabel>
<deletedAxiom>&apos;Ubiquitin-Conjugating Enzyme E2 D2&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Turnover&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBE2D2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ubiquitin-Conjugating Enzyme E2 D2&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Turnover&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBE2D2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2646</classIRI>
<classLabel>L-Dopachrome Tautomerase</classLabel>
<deletedAxiom>&apos;L-Dopachrome Tautomerase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Isomerase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25985</classIRI>
<classLabel>Chemokine-Like Receptor 1</classLabel>
<deletedAxiom>&apos;Chemokine-Like Receptor 1&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Parathyroid Gland&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CMKLR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Chemokine-Like Receptor 1&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Parathyroid Gland&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CMKLR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25988</classIRI>
<classLabel>Serine/Threonine-Protein Kinase PLK3</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase PLK3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK3 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Polo-Box Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLK3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase PLK3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK3 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Polo-Box Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLK3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25997</classIRI>
<classLabel>Adaptor Signaling Protein Gene</classLabel>
<newAxiom>&apos;Adaptor Signaling Protein Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Protein-Protein Interaction&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25920</classIRI>
<classLabel>Choline Kinase Alpha</classLabel>
<deletedAxiom>&apos;Choline Kinase Alpha&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylcholine Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerophospholipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Colorectal Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Prostate Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphatidylcholine Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHKA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Choline Kinase Alpha&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylcholine Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerophospholipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Colorectal Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Prostate Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphatidylcholine Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHKA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25921</classIRI>
<classLabel>Muscarinic Acetylcholine Receptor M4</classLabel>
<deletedAxiom>&apos;Muscarinic Acetylcholine Receptor M4&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRM4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Muscarinic Acetylcholine Receptor M4&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRM4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25948</classIRI>
<classLabel>Cytochrome P450 2C19</classLabel>
<deletedAxiom>&apos;Cytochrome P450 2C19&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2C19 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 2C19&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2C19 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25959</classIRI>
<classLabel>Endoribonuclease</classLabel>
<deletedAxiom>&apos;Endoribonuclease&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ribonuclease&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49206</classIRI>
<classLabel>7,8-Dihydro-8-Oxoguanine Triphosphatase</classLabel>
<deletedAxiom>&apos;7,8-Dihydro-8-Oxoguanine Triphosphatase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NUDT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;7,8-Dihydro-8-Oxoguanine Triphosphatase&apos; SubClassOf &apos;Hydrolase&apos;</newAxiom>
<newAxiom>&apos;7,8-Dihydro-8-Oxoguanine Triphosphatase&apos; SubClassOf &apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;</newAxiom>
<newAxiom>&apos;7,8-Dihydro-8-Oxoguanine Triphosphatase&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NUDT1 Gene&apos;</newAxiom>
<newAxiom>&apos;7,8-Dihydro-8-Oxoguanine Triphosphatase&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;</newAxiom>
<newAxiom>&apos;7,8-Dihydro-8-Oxoguanine Triphosphatase&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93093</classIRI>
<classLabel>Histone-Lysine N-Methyltransferase 2C</classLabel>
<deletedAxiom>&apos;Histone-Lysine N-Methyltransferase 2C&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;AT Hook Motif&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SET Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KMT2C Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone-Lysine N-Methyltransferase 2C&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;AT Hook Motif&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SET Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KMT2C Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37309</classIRI>
<classLabel>Receptor-Type Tyrosine-Protein Phosphatase Epsilon</classLabel>
<deletedAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase Epsilon&apos; EquivalentTo &apos;PTPRE Gene Product&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRE Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase Epsilon&apos; EquivalentTo &apos;PTPRE Gene Product&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRE Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37315</classIRI>
<classLabel>Receptor-Type Tyrosine-Protein Phosphatase T</classLabel>
<deletedAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase T&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase T&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37314</classIRI>
<classLabel>Receptor-Type Tyrosine-Protein Phosphatase R</classLabel>
<deletedAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase R&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase R&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37317</classIRI>
<classLabel>Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Double Prime Subunit Beta</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Double Prime Subunit Beta&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Muscle Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R3B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Double Prime Subunit Beta&apos; EquivalentTo &apos;Protein Phosphatase Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Muscle Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Phosphatase 2A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP2R3B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37311</classIRI>
<classLabel>Receptor-Type Tyrosine-Protein Phosphatase Gamma</classLabel>
<deletedAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase Gamma&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase Gamma&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRG Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37310</classIRI>
<classLabel>Receptor-Type Tyrosine-Protein Phosphatase Epsilon Isoform 2</classLabel>
<deletedAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase Epsilon Isoform 2&apos; EquivalentTo &apos;PTPRE Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytoplasmic Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRE Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase Epsilon Isoform 2&apos; EquivalentTo &apos;PTPRE Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytoplasmic Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRE Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37313</classIRI>
<classLabel>Receptor-Type Tyrosine-Protein Phosphatase Eta</classLabel>
<deletedAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase Eta&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRJ Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase Eta&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRJ Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37273</classIRI>
<classLabel>Protein Tyrosine Phosphatase Type IVA 1</classLabel>
<deletedAxiom>&apos;Protein Tyrosine Phosphatase Type IVA 1&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTP4A Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTP4A1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein Tyrosine Phosphatase Type IVA 1&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTP4A Family Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTP4A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75884</classIRI>
<classLabel>Ornithine Carbamoyltransferase, Mitochondrial</classLabel>
<deletedAxiom>&apos;Ornithine Carbamoyltransferase, Mitochondrial&apos; EquivalentTo &apos;Transferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;OTC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ornithine Carbamoyltransferase, Mitochondrial&apos; EquivalentTo &apos;Transferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;OTC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75873</classIRI>
<classLabel>Steroidogenic Factor 1</classLabel>
<deletedAxiom>&apos;Steroidogenic Factor 1&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Sexual Maturation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR5A1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Steroidogenic Factor 1&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Sexual Maturation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR5A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75866</classIRI>
<classLabel>Nuclear Receptor Subfamily 0 Group B Member 1</classLabel>
<deletedAxiom>&apos;Nuclear Receptor Subfamily 0 Group B Member 1&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Organogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR0B1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Nuclear Receptor Subfamily 0 Group B Member 1&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Organogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR0B1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75869</classIRI>
<classLabel>COUP Transcription Factor 2</classLabel>
<deletedAxiom>&apos;COUP Transcription Factor 2&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR2F2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;COUP Transcription Factor 2&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR2F2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75735</classIRI>
<classLabel>NADH Dehydrogenase [Ubiquinone] Flavoprotein 1, Mitochondrial</classLabel>
<deletedAxiom>&apos;NADH Dehydrogenase [Ubiquinone] Flavoprotein 1, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Respiration&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NDUFV1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NADH Dehydrogenase [Ubiquinone] Flavoprotein 1, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Respiration&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NDUFV1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75606</classIRI>
<classLabel>Iduronate 2-Sulfatase</classLabel>
<deletedAxiom>&apos;Iduronate 2-Sulfatase&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Esterase&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IDS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Iduronate 2-Sulfatase&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IDS Gene&apos;</newAxiom>
<newAxiom>&apos;Iduronate 2-Sulfatase&apos; SubClassOf &apos;Esterase&apos;</newAxiom>
<newAxiom>&apos;Iduronate 2-Sulfatase&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Degradation Pathway&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111042</classIRI>
<classLabel>JAK2 Inhibitor WP1066</classLabel>
<deletedAxiom>&apos;JAK2 Inhibitor WP1066&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;JAK2 Inhibitor WP1066&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125450</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68596</classIRI>
<classLabel>Aurora Kinase B</classLabel>
<deletedAxiom>&apos;Aurora Kinase B&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora B Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora C Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokinesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AURKB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Aurora Kinase B&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora B Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora C Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokinesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68584</classIRI>
<classLabel>E3 Ubiquitin-protein Ligase NEDD4 Protein</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-protein Ligase NEDD4 Protein&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C92513</classIRI>
<classLabel>Sphingosine Kinase 1</classLabel>
<deletedAxiom>&apos;Sphingosine Kinase 1&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolic Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SPHK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Sphingosine Kinase 1&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolic Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SPHK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C92520</classIRI>
<classLabel>Serine/Threonine-Protein Kinase SIK2</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase SIK2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SIK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase SIK2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SIK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68729</classIRI>
<classLabel>Arachidonate 5-Lipoxygenase</classLabel>
<deletedAxiom>&apos;Arachidonate 5-Lipoxygenase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38906</classIRI>
<classLabel>Tumor Necrosis Factor Receptor Superfamily Member 8</classLabel>
<deletedAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 8&apos; EquivalentTo &apos;TNFRSF8 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Of&apos; some &apos;Hodgkin Lymphoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 8&apos; EquivalentTo &apos;TNFRSF8 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Of&apos; some &apos;Hodgkin Lymphoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38929</classIRI>
<classLabel>Serine/Threonine-Protein Kinase mTOR</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase mTOR&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Muscle Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stat3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Class I PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGFR-Dependent Endothelin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;mTORC1&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;mTORC2&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MTOR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase mTOR&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Muscle Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stat3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Class I PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGFR-Dependent Endothelin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;mTORC1&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;mTORC2&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MTOR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38925</classIRI>
<classLabel>Inosine-5&apos;-Monophosphate Dehydrogenase 2</classLabel>
<deletedAxiom>&apos;Inosine-5&apos;-Monophosphate Dehydrogenase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Peroxisome&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IMPDH2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Inosine-5&apos;-Monophosphate Dehydrogenase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Peroxisome&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IMPDH2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45562</classIRI>
<classLabel>Amidophosphoribosyltransferase</classLabel>
<deletedAxiom>&apos;Amidophosphoribosyltransferase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metal Ion Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Biosynthesis Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPAT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Amidophosphoribosyltransferase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metal Ion Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Biosynthesis Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPAT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38923</classIRI>
<classLabel>Inosine-5&apos;-Monophosphate Dehydrogenase 1</classLabel>
<deletedAxiom>&apos;Inosine-5&apos;-Monophosphate Dehydrogenase 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IMPDH1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Inosine-5&apos;-Monophosphate Dehydrogenase 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IMPDH1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38947</classIRI>
<classLabel>Poly(A) Polymerase Alpha</classLabel>
<deletedAxiom>&apos;Poly(A) Polymerase Alpha&apos; EquivalentTo &apos;Riboadenylate Transferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Polyadenylation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Riboadenylate Transferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Polyadenylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAPOLA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Poly(A) Polymerase Alpha&apos; EquivalentTo &apos;Riboadenylate Transferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Polyadenylation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Polyadenylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAPOLA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38949</classIRI>
<classLabel>Poly(A) Polymerase Beta</classLabel>
<deletedAxiom>&apos;Poly(A) Polymerase Beta&apos; EquivalentTo &apos;Riboadenylate Transferase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Riboadenylate Transferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Polyadenylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAPOLB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Poly(A) Polymerase Beta&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Polyadenylation&apos;</newAxiom>
<newAxiom>&apos;Poly(A) Polymerase Beta&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAPOLB Gene&apos;</newAxiom>
<newAxiom>&apos;Poly(A) Polymerase Beta&apos; SubClassOf &apos;Riboadenylate Transferase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38951</classIRI>
<classLabel>Poly(A) Polymerase Gamma</classLabel>
<deletedAxiom>&apos;Poly(A) Polymerase Gamma&apos; EquivalentTo &apos;Riboadenylate Transferase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Riboadenylate Transferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Polyadenylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAPOLG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Poly(A) Polymerase Gamma&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAPOLG Gene&apos;</newAxiom>
<newAxiom>&apos;Poly(A) Polymerase Gamma&apos; SubClassOf &apos;Riboadenylate Transferase&apos;</newAxiom>
<newAxiom>&apos;Poly(A) Polymerase Gamma&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Polyadenylation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91751</classIRI>
<classLabel>Peroxisome Proliferator-Activated Receptor Alpha</classLabel>
<deletedAxiom>&apos;Peroxisome Proliferator-Activated Receptor Alpha&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Desensitization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPARA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Peroxisome Proliferator-Activated Receptor Alpha&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Desensitization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPARA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14254</classIRI>
<classLabel>Human Parainfluenza Virus 1</classLabel>
<deletedAxiom>&apos;Human Parainfluenza Virus 1&apos; SubClassOf &apos;Parainfluenza Virus&apos;</deletedAxiom>
<newAxiom>&apos;Human Parainfluenza Virus 1&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125641</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104237</classIRI>
<classLabel>Cytochrome P450 1B1</classLabel>
<deletedAxiom>&apos;Cytochrome P450 1B1&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Eye Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP1B1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 1B1&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Eye Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP1B1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104214</classIRI>
<classLabel>Tyrosine-Protein Phosphatase Non-Receptor Type 13</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 13&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Reverse Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN13 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 13&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Reverse Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN13 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91777</classIRI>
<classLabel>Ras GTPase-Activating Protein 1</classLabel>
<deletedAxiom>&apos;Ras GTPase-Activating Protein 1&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora B Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase-Activating Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell-Matrix Adhesion&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RASA1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ras GTPase-Activating Protein 1&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora B Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell-Matrix Adhesion&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RASA1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91860</classIRI>
<classLabel>Disintegrin and Metalloproteinase Domain-Containing Protein 10</classLabel>
<deletedAxiom>&apos;Disintegrin and Metalloproteinase Domain-Containing Protein 10&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyloid Beta-Peptide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;ADAM Family Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADAM Type Metalloprotease Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAM10 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Disintegrin and Metalloproteinase Domain-Containing Protein 10&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyloid Beta-Peptide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;ADAM Family Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADAM Type Metalloprotease Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAM10 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91866</classIRI>
<classLabel>MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2</classLabel>
<deletedAxiom>&apos;MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MKNK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MKNK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91825</classIRI>
<classLabel>Pappalysin-1</classLabel>
<deletedAxiom>&apos;Pappalysin-1&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Sushi Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAPPA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Pappalysin-1&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Sushi Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAPPA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104340</classIRI>
<classLabel>60 kDa Heat Shock Protein, Mitochondrial</classLabel>
<deletedAxiom>&apos;60 kDa Heat Shock Protein, Mitochondrial&apos; EquivalentTo &apos;Chaperone&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type I Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrial Matrix&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transport Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chaperone&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HSPD1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;60 kDa Heat Shock Protein, Mitochondrial&apos; EquivalentTo &apos;Chaperone&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type I Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrial Matrix&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transport Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HSPD1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45914</classIRI>
<classLabel>Long-Chain-Fatty-Acid-CoA Ligase 1</classLabel>
<deletedAxiom>&apos;Long-Chain-Fatty-Acid-CoA Ligase 1&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACSL1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Long-Chain-Fatty-Acid-CoA Ligase 1&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACSL1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45999</classIRI>
<classLabel>Cytochrome P450 3A5</classLabel>
<deletedAxiom>&apos;Cytochrome P450 3A5&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP3A5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 3A5&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP3A5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104127</classIRI>
<classLabel>Ceramide Synthase 5</classLabel>
<newAxiom>&apos;Ceramide Synthase 5&apos; SubClassOf &apos;Acyltransferase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104136</classIRI>
<classLabel>M-Phase Inducer Phosphatase 3</classLabel>
<newAxiom>&apos;M-Phase Inducer Phosphatase 3&apos; SubClassOf &apos;Protein Tyrosine Phosphatase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104707</classIRI>
<classLabel>Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha</classLabel>
<deletedAxiom>&apos;Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Synapse&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CAMK2A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Synapse&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CAMK2A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38500</classIRI>
<classLabel>Aspartate Aminotransferase, Cytoplasmic</classLabel>
<deletedAxiom>&apos;Aspartate Aminotransferase, Cytoplasmic&apos; EquivalentTo &apos;SGOT (AST)&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phenylalanine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phenylalanine, Tyrosine and Tryptophan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tyrosine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Malate-Aspartate Shuttle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GOT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Aspartate Aminotransferase, Cytoplasmic&apos; EquivalentTo &apos;SGOT (AST)&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phenylalanine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phenylalanine, Tyrosine and Tryptophan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tyrosine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Malate-Aspartate Shuttle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GOT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38502</classIRI>
<classLabel>Aspartate Aminotransferase, Mitochondrial</classLabel>
<deletedAxiom>&apos;Aspartate Aminotransferase, Mitochondrial&apos; EquivalentTo &apos;SGOT (AST)&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phenylalanine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phenylalanine, Tyrosine and Tryptophan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tyrosine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GOT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Aspartate Aminotransferase, Mitochondrial&apos; EquivalentTo &apos;SGOT (AST)&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phenylalanine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phenylalanine, Tyrosine and Tryptophan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tyrosine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GOT2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38509</classIRI>
<classLabel>Alanine Aminotransferase 2</classLabel>
<deletedAxiom>&apos;Alanine Aminotransferase 2&apos; EquivalentTo &apos;SGPT (ALT)&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transaminase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gluconeogenic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Alanine Aminotransferase 2&apos; EquivalentTo &apos;SGPT (ALT)&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gluconeogenic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPT2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38507</classIRI>
<classLabel>Alanine Aminotransferase 1</classLabel>
<deletedAxiom>&apos;Alanine Aminotransferase 1&apos; EquivalentTo &apos;SGPT (ALT)&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SARS Coronavirus Protease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gluconeogenic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Alanine Aminotransferase 1&apos; EquivalentTo &apos;SGPT (ALT)&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SARS Coronavirus Protease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gluconeogenic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38527</classIRI>
<classLabel>Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform&apos; EquivalentTo (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Vesicle Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Calcineurin&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP3CC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform&apos; EquivalentTo (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Vesicle Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Calcineurin&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP3CC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38525</classIRI>
<classLabel>Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform&apos; EquivalentTo (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Vesicle Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Calcineurin&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP3CB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform&apos; EquivalentTo (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Vesicle Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Calcineurin&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP3CB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38523</classIRI>
<classLabel>Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform</classLabel>
<deletedAxiom>&apos;Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Vesicle Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Calcineurin&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP3CA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Skeletal Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Vesicle Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Calcineurin&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PPP3CA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38565</classIRI>
<classLabel>Nitric Oxide Synthase, Inducible</classLabel>
<deletedAxiom>&apos;Nitric Oxide Synthase, Inducible&apos; EquivalentTo &apos;Nitric Oxide Synthetase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NO2-Dependent IL12 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL23-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NOS2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Nitric Oxide Synthase, Inducible&apos; EquivalentTo &apos;Nitric Oxide Synthetase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NO2-Dependent IL12 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL23-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NOS2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38563</classIRI>
<classLabel>Nitric Oxide Synthase, Brain</classLabel>
<deletedAxiom>&apos;Nitric Oxide Synthase, Brain&apos; EquivalentTo &apos;Nitric Oxide Synthetase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation in Modulation of CtBP-Dependent Gene Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NOS1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Nitric Oxide Synthase, Brain&apos; EquivalentTo &apos;Nitric Oxide Synthetase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation in Modulation of CtBP-Dependent Gene Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NOS1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38571</classIRI>
<classLabel>Nitric Oxide Synthase, Endothelial</classLabel>
<deletedAxiom>&apos;Nitric Oxide Synthase, Endothelial&apos; EquivalentTo &apos;Nitric Oxide Synthetase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Corticosteroid Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia-Inducible Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channels in Vascular Endothelium Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Platelet Aggregation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Muscle Contraction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NOS3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Nitric Oxide Synthase, Endothelial&apos; EquivalentTo &apos;Nitric Oxide Synthetase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Corticosteroid Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia-Inducible Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channels in Vascular Endothelium Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Platelet Aggregation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Muscle Contraction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NOS3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104800</classIRI>
<classLabel>Serine/Threonine-Protein Kinase Pim-2</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase Pim-2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1/S Transition Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Autophagy&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIM2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase Pim-2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1/S Transition Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Autophagy&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIM2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104824</classIRI>
<classLabel>1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1</classLabel>
<deletedAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channel and Phorbal Esters Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphoinositide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Trka Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vibrio cholerae Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E-Cadherin Signaling Pathway in Keratinocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nephrin Signaling Pathway in the Kidney Podocyte&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-alpha Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLCG1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channel and Phorbal Esters Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphoinositide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Trka Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vibrio cholerae Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E-Cadherin Signaling Pathway in Keratinocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nephrin Signaling Pathway in the Kidney Podocyte&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-alpha Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLCG1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104838</classIRI>
<classLabel>M-Phase Inducer Phosphatase 2</classLabel>
<newAxiom>&apos;M-Phase Inducer Phosphatase 2&apos; SubClassOf &apos;Protein Tyrosine Phosphatase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38428</classIRI>
<classLabel>Guanylate Cyclase Soluble Subunit Beta-2</classLabel>
<deletedAxiom>&apos;Guanylate Cyclase Soluble Subunit Beta-2&apos; SubClassOf &apos;Lyase&apos;</deletedAxiom>
<deletedAxiom>&apos;Guanylate Cyclase Soluble Subunit Beta-2&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</deletedAxiom>
<deletedAxiom>&apos;Guanylate Cyclase Soluble Subunit Beta-2&apos; SubClassOf &apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;</deletedAxiom>
<deletedAxiom>&apos;Guanylate Cyclase Soluble Subunit Beta-2&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channels in Vascular Endothelium Pathway&apos;</deletedAxiom>
<deletedAxiom>&apos;Guanylate Cyclase Soluble Subunit Beta-2&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;</deletedAxiom>
<deletedAxiom>&apos;Guanylate Cyclase Soluble Subunit Beta-2&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Soluble Guanylate Cyclase&apos;</deletedAxiom>
<deletedAxiom>&apos;Guanylate Cyclase Soluble Subunit Beta-2&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GUCY1B2 Gene&apos;</deletedAxiom>
<newAxiom>&apos;Guanylate Cyclase Soluble Subunit Beta-2&apos; EquivalentTo &apos;Lyase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channels in Vascular Endothelium Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Soluble Guanylate Cyclase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GUCY1B2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38420</classIRI>
<classLabel>Retinoic Acid Receptor RXR-Gamma</classLabel>
<deletedAxiom>&apos;Retinoic Acid Receptor RXR-Gamma&apos; EquivalentTo &apos;Retinoid X Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Retinoic Acid Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RXRG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Retinoic Acid Receptor RXR-Gamma&apos; EquivalentTo &apos;Retinoid X Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Retinoic Acid Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RXRG Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38410</classIRI>
<classLabel>cAMP-Dependent Protein Kinase Catalytic Subunit Alpha</classLabel>
<deletedAxiom>&apos;cAMP-Dependent Protein Kinase Catalytic Subunit Alpha&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Kinase A Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C-Epsilon Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Taste Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dilated Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vasopressin-Regulated Water Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKACA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;cAMP-Dependent Protein Kinase Catalytic Subunit Alpha&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Kinase A Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C-Epsilon Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Taste Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dilated Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vasopressin-Regulated Water Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aurora A Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKACA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38412</classIRI>
<classLabel>cAMP-Dependent Protein Kinase Catalytic Subunit Beta</classLabel>
<deletedAxiom>&apos;cAMP-Dependent Protein Kinase Catalytic Subunit Beta&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CARM1 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CFTR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pain Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th2 Cytokine Gene Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Kinase A Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C-Epsilon Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Taste Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dilated Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vasopressin-Regulated Water Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKACB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;cAMP-Dependent Protein Kinase Catalytic Subunit Beta&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CARM1 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CFTR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pain Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th2 Cytokine Gene Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Kinase A Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C-Epsilon Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Taste Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dilated Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vasopressin-Regulated Water Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKACB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38414</classIRI>
<classLabel>cAMP-Dependent Protein Kinase Catalytic Subunit Gamma</classLabel>
<deletedAxiom>&apos;cAMP-Dependent Protein Kinase Catalytic Subunit Gamma&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CARM1 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CFTR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pain Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th2 Cytokine Gene Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Kinase A Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C-Epsilon Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Taste Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dilated Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vasopressin-Regulated Water Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase A&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKACG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;cAMP-Dependent Protein Kinase Catalytic Subunit Gamma&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stress Fiber Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CARM1 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CFTR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ChREBP Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pain Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Th2 Cytokine Gene Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Kinase A Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C-Epsilon Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Taste Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dilated Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vasopressin-Regulated Water Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase A&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKACG Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38416</classIRI>
<classLabel>Retinoic Acid Receptor RXR-Alpha</classLabel>
<deletedAxiom>&apos;Retinoic Acid Receptor RXR-Alpha&apos; EquivalentTo &apos;Retinoid X Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CARM1 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Map Kinase Inactivation of SMRT Corepressor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Cholesterol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Obesity and Thermogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RAR and RXR Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chromatin Remodeling Complex and Coactivator Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Expression Regulation by Vitamin D Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolic Syndrome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinoic Acid Receptor Family-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Retinoic Acid Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RXRA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Retinoic Acid Receptor RXR-Alpha&apos; EquivalentTo &apos;Retinoid X Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CARM1 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Map Kinase Inactivation of SMRT Corepressor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Cholesterol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Obesity and Thermogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RAR and RXR Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chromatin Remodeling Complex and Coactivator Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Expression Regulation by Vitamin D Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolic Syndrome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinoic Acid Receptor Family-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Retinoic Acid Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RXRA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38418</classIRI>
<classLabel>Retinoic Acid Receptor RXR-Beta</classLabel>
<deletedAxiom>&apos;Retinoic Acid Receptor RXR-Beta&apos; EquivalentTo &apos;Retinoid X Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Retinoic Acid Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RXRB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Retinoic Acid Receptor RXR-Beta&apos; EquivalentTo &apos;Retinoid X Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Retinoic Acid Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RXRB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104797</classIRI>
<classLabel>E3 SUMO-Protein Ligase PIAS1</classLabel>
<deletedAxiom>&apos;E3 SUMO-Protein Ligase PIAS1&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RANBP2-Mediated Sumoylation Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Interferon Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIAS1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 SUMO-Protein Ligase PIAS1&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RANBP2-Mediated Sumoylation Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Interferon Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIAS1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38435</classIRI>
<classLabel>Polyubiquitin-C</classLabel>
<deletedAxiom>&apos;Polyubiquitin-C&apos; EquivalentTo &apos;Ubiquitin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitin&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gene Expression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Degradation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Stress Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Polyubiquitin-C&apos; EquivalentTo &apos;Ubiquitin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gene Expression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Degradation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Stress Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38432</classIRI>
<classLabel>Polyubiquitin-B</classLabel>
<deletedAxiom>&apos;Polyubiquitin-B&apos; EquivalentTo &apos;Ubiquitin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitin&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gene Expression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Degradation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Stress Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Polyubiquitin-B&apos; EquivalentTo &apos;Ubiquitin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gene Expression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Degradation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Stress Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38496</classIRI>
<classLabel>Hypoxanthine-Guanine Phosphoribosyltransferase</classLabel>
<deletedAxiom>&apos;Hypoxanthine-Guanine Phosphoribosyltransferase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HPRT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Hypoxanthine-Guanine Phosphoribosyltransferase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HPRT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104402</classIRI>
<classLabel>Alpha-(1,3)-Fucosyltransferase 4</classLabel>
<newAxiom>&apos;Alpha-(1,3)-Fucosyltransferase 4&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Fucosyltransferase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104508</classIRI>
<classLabel>Histone Deacetylase 10</classLabel>
<deletedAxiom>&apos;Histone Deacetylase 10&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Deacetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC10 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Deacetylase 10&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Deacetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC10 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38361</classIRI>
<classLabel>Estrogen Receptor</classLabel>
<deletedAxiom>&apos;Estrogen Receptor&apos; EquivalentTo &apos;Estrogen Receptor Family&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EFP Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MTA3 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pelp1 Estrogen Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tert Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hormone Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ESR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Estrogen Receptor&apos; EquivalentTo &apos;Estrogen Receptor Family&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EFP Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MTA3 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pelp1 Estrogen Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tert Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hormone Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ESR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38364</classIRI>
<classLabel>Estrogen Receptor Beta</classLabel>
<deletedAxiom>&apos;Estrogen Receptor Beta&apos; EquivalentTo &apos;Estrogen Receptor Family&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hormone Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ESR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Estrogen Receptor Beta&apos; EquivalentTo &apos;Estrogen Receptor Family&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hormone Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ESR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38366</classIRI>
<classLabel>DNA Topoisomerase 3-Beta-1</classLabel>
<deletedAxiom>&apos;DNA Topoisomerase 3-Beta-1&apos; EquivalentTo &apos;Topoisomerase III&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Homologous Recombination Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Topoisomerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Aging&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Maintenance&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOP3B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Topoisomerase 3-Beta-1&apos; EquivalentTo &apos;Topoisomerase III&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Homologous Recombination Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Aging&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Maintenance&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOP3B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C100091</classIRI>
<classLabel>Eosinophil Lysophospholipase</classLabel>
<deletedAxiom>&apos;Eosinophil Lysophospholipase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104986</classIRI>
<classLabel>Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 Isoform 3</classLabel>
<deletedAxiom>&apos;Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 Isoform 3&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104973</classIRI>
<classLabel>Phospholipase A2</classLabel>
<deletedAxiom>&apos;Phospholipase A2&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Eicosanoid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerophospholipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ether Lipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;alpha-Linolenic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Phospholipase A2 Enzyme Family&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLA2G1B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Phospholipase A2&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Eicosanoid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerophospholipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ether Lipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;alpha-Linolenic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Phospholipase A2 Enzyme Family&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLA2G1B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84993</classIRI>
<classLabel>Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5 Protein</classLabel>
<deletedAxiom>&apos;Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5 Protein&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84996</classIRI>
<classLabel>Tumor Necrosis Factor Alpha-Induced Protein 3</classLabel>
<deletedAxiom>&apos;Tumor Necrosis Factor Alpha-Induced Protein 3&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40/CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Regulator&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFAIP3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tumor Necrosis Factor Alpha-Induced Protein 3&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40/CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Regulator&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFAIP3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84997</classIRI>
<classLabel>Aldehyde Dehydrogenase, Mitochondrial</classLabel>
<deletedAxiom>&apos;Aldehyde Dehydrogenase, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ascorbate and Aldarate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycolysis/Gluconeogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Histidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysine Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pentose and Glucuronate Interconversions Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Propanoate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyruvate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Valine, Leucine and Isoleucine Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Limonene and Pinene Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Aldehyde Dehydrogenase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALDH2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Aldehyde Dehydrogenase, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ascorbate and Aldarate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycolysis/Gluconeogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Histidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysine Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pentose and Glucuronate Interconversions Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Propanoate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyruvate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Valine, Leucine and Isoleucine Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Limonene and Pinene Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Aldehyde Dehydrogenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALDH2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84317</classIRI>
<classLabel>Ribosomal Protein S6 Kinase Beta-1</classLabel>
<deletedAxiom>&apos;Ribosomal Protein S6 Kinase Beta-1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RPS6KB1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ribosomal Protein S6 Kinase Beta-1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RPS6KB1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84326</classIRI>
<classLabel>Complement Factor D</classLabel>
<deletedAxiom>&apos;Complement Factor D&apos; EquivalentTo &apos;Complement Component Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative Complement Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Complement Component Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Host Defense Mechanism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Complement Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CFD Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Complement Factor D&apos; EquivalentTo &apos;Complement Component Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative Complement Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Host Defense Mechanism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Complement Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CFD Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84349</classIRI>
<classLabel>Tumor Suppressor ARF</classLabel>
<deletedAxiom>&apos;Tumor Suppressor ARF&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ribosomal Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Melanoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Pancreatic Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of G2 Phase&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN2A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tumor Suppressor ARF&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ribosomal Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Melanoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Pancreatic Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of G2 Phase&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN2A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45487</classIRI>
<classLabel>G1/S-Specific Cyclin-D2</classLabel>
<deletedAxiom>&apos;G1/S-Specific Cyclin-D2&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCND2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G1/S-Specific Cyclin-D2&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCND2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45486</classIRI>
<classLabel>Cholinesterase</classLabel>
<deletedAxiom>&apos;Cholinesterase&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Esterase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biogenic Amine Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCHE Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cholinesterase&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biogenic Amine Metabolic Process&apos;</newAxiom>
<newAxiom>&apos;Cholinesterase&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCHE Gene&apos;</newAxiom>
<newAxiom>&apos;Cholinesterase&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;</newAxiom>
<newAxiom>&apos;Cholinesterase&apos; SubClassOf &apos;Esterase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45498</classIRI>
<classLabel>Tyrosine-Protein Kinase Fes/Fps</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Fes/Fps&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FES Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Fes/Fps&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FES Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99184</classIRI>
<classLabel>Tartrate-Resistant Acid Phosphatase Type 5</classLabel>
<deletedAxiom>&apos;Tartrate-Resistant Acid Phosphatase Type 5&apos; EquivalentTo &apos;ACP5 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Riboflavin Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Metalloprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lysosome&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Macrophage&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Dendritic Cell&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACP5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tartrate-Resistant Acid Phosphatase Type 5&apos; EquivalentTo &apos;ACP5 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Riboflavin Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Metalloprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lysosome&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Macrophage&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Dendritic Cell&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACP5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99185</classIRI>
<classLabel>Tartrate-Resistant Acid Phosphatase Type 5b</classLabel>
<deletedAxiom>&apos;Tartrate-Resistant Acid Phosphatase Type 5b&apos; EquivalentTo &apos;ACP5 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Riboflavin Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Metalloprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lysosome&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Osteoclast&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Bone Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACP5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tartrate-Resistant Acid Phosphatase Type 5b&apos; EquivalentTo &apos;ACP5 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Riboflavin Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Metalloprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lysosome&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Osteoclast&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Bone Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACP5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9145</classIRI>
<classLabel>Osteosarcoma</classLabel>
<deletedAxiom>&apos;Osteosarcoma&apos; EquivalentTo &apos;Osteogenic Neoplasm&apos; and &apos;Infrequent Neoplasm&apos; and &apos;Sarcoma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Osteoblast&apos;)</deletedAxiom>
<newAxiom>&apos;Osteosarcoma&apos; EquivalentTo &apos;Osteogenic Neoplasm&apos; and &apos;Sarcoma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Osteoblast&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99659</classIRI>
<classLabel>G-Protein Coupled Receptor 56</classLabel>
<deletedAxiom>&apos;G-Protein Coupled Receptor 56&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell-Cell Adhesion Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPR56 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G-Protein Coupled Receptor 56&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell-Cell Adhesion Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPR56 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99467</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase RNF146</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase RNF146&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Communication Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNF146 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase RNF146&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Communication Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNF146 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99470</classIRI>
<classLabel>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</classLabel>
<deletedAxiom>&apos;Alpha-Ketoglutarate-Dependent Dioxygenase FTO&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99476</classIRI>
<classLabel>D-3-Phosphoglycerate Dehydrogenase</classLabel>
<deletedAxiom>&apos;D-3-Phosphoglycerate Dehydrogenase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycine, Serine and Threonine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nervous System Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Amino Acid Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PHGDH Gene&apos;)</deletedAxiom>
<newAxiom>&apos;D-3-Phosphoglycerate Dehydrogenase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycine, Serine and Threonine Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nervous System Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Amino Acid Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PHGDH Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99473</classIRI>
<classLabel>Carnitine O-Palmitoyltransferase 1, Brain Isoform</classLabel>
<deletedAxiom>&apos;Carnitine O-Palmitoyltransferase 1, Brain Isoform&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Outer Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Acyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CPT1C Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Carnitine O-Palmitoyltransferase 1, Brain Isoform&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Outer Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CPT1C Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99479</classIRI>
<classLabel>Serine/Threonine-Protein Kinase 3</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase 3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;STK3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase 3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;STK3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99483</classIRI>
<classLabel>Serine/Threonine-Protein Kinase 4</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;STK4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;STK4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105039</classIRI>
<classLabel>Sphingomyelin Phosphodiesterase 4</classLabel>
<deletedAxiom>&apos;Sphingomyelin Phosphodiesterase 4&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Trans-Golgi Network&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMPD4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Sphingomyelin Phosphodiesterase 4&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Trans-Golgi Network&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMPD4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105021</classIRI>
<classLabel>Sphingomyelin Phosphodiesterase</classLabel>
<deletedAxiom>&apos;Sphingomyelin Phosphodiesterase&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TRAIL Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lumen of the Lysosome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMPD1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Sphingomyelin Phosphodiesterase&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TRAIL Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lumen of the Lysosome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMPD1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105026</classIRI>
<classLabel>Sphingomyelin Phosphodiesterase 2</classLabel>
<deletedAxiom>&apos;Sphingomyelin Phosphodiesterase 2&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMPD2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Sphingomyelin Phosphodiesterase 2&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMPD2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105032</classIRI>
<classLabel>Sphingomyelin Phosphodiesterase 3</classLabel>
<deletedAxiom>&apos;Sphingomyelin Phosphodiesterase 3&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMPD3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Sphingomyelin Phosphodiesterase 3&apos; EquivalentTo &apos;Phospholipase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMPD3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91394</classIRI>
<classLabel>JAK2 Inhibitor AZD1480</classLabel>
<deletedAxiom>&apos;JAK2 Inhibitor AZD1480&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;JAK2 Inhibitor AZD1480&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125450</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91371</classIRI>
<classLabel>Atypical Chemokine Receptor 3</classLabel>
<deletedAxiom>&apos;Atypical Chemokine Receptor 3&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chemokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACKR3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Atypical Chemokine Receptor 3&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACKR3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91300</classIRI>
<classLabel>Dipeptidyl Peptidase 4</classLabel>
<deletedAxiom>&apos;Dipeptidyl Peptidase 4&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell-Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DPP4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dipeptidyl Peptidase 4&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell-Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DPP4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105116</classIRI>
<classLabel>Prostaglandin E Synthase 2</classLabel>
<deletedAxiom>&apos;Prostaglandin E Synthase 2&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Isomerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Prostaglandin Production&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTGES2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Prostaglandin E Synthase 2&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Prostaglandin Production&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTGES2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91268</classIRI>
<classLabel>Probable E3 Ubiquitin-Protein Ligase TRIP12</classLabel>
<deletedAxiom>&apos;Probable E3 Ubiquitin-Protein Ligase TRIP12&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;PA700 Regulatory Module&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIP12 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Probable E3 Ubiquitin-Protein Ligase TRIP12&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;PA700 Regulatory Module&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIP12 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91278</classIRI>
<classLabel>Heparanase-2</classLabel>
<deletedAxiom>&apos;Heparanase-2&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neovascularization&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metastasis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Extracellular Matrix Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HPSE2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Heparanase-2&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neovascularization&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metastasis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Extracellular Matrix Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HPSE2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91290</classIRI>
<classLabel>Polyribonucleotide Nucleotidyltransferase 1, Mitochondrial</classLabel>
<deletedAxiom>&apos;Polyribonucleotide Nucleotidyltransferase 1, Mitochondrial&apos; EquivalentTo &apos;Nucleotidyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Nucleotidyltransferase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;3&apos;-5&apos; Exonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PNPT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Polyribonucleotide Nucleotidyltransferase 1, Mitochondrial&apos; EquivalentTo &apos;Nucleotidyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;3&apos;-5&apos; Exonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PNPT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105396</classIRI>
<classLabel>Cyclin-C</classLabel>
<deletedAxiom>&apos;Cyclin-C&apos; EquivalentTo &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Mediator Complex&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Coactivator&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-C&apos; EquivalentTo &apos;Cyclin&apos; and &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Mediator Complex&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Coactivator&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90154</classIRI>
<classLabel>Serine/Threonine-Protein Kinase NLK</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase NLK&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Fate Control&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NLK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase NLK&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Fate Control&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NLK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105368</classIRI>
<classLabel>High Affinity Nerve Growth Factor Receptor Isoform TrkA-III</classLabel>
<deletedAxiom>&apos;High Affinity Nerve Growth Factor Receptor Isoform TrkA-III&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105367</classIRI>
<classLabel>NTRK1 Gene Product</classLabel>
<deletedAxiom>&apos;NTRK1 Gene Product&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C60656</classIRI>
<classLabel>Death-Associated Protein Kinase 1</classLabel>
<deletedAxiom>&apos;Death-Associated Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Death Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Promoter&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DAPK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Death-Associated Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Death Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Promoter&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DAPK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105400</classIRI>
<classLabel>Metallothionein-1G</classLabel>
<deletedAxiom>&apos;Metallothionein-1G&apos; EquivalentTo &apos;Metallothionein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Trace Metal Storage Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chelating Activity&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MT1G Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Metallothionein-1G&apos; EquivalentTo &apos;Metallothionein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Nuclear Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chelating Activity&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MT1G Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90326</classIRI>
<classLabel>Serine/Threonine-Protein Kinase Nek10</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase Nek10&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90316</classIRI>
<classLabel>Disintegrin and Metalloproteinase Domain-Containing Protein 8</classLabel>
<deletedAxiom>&apos;Disintegrin and Metalloproteinase Domain-Containing Protein 8&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;ADAM Family Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Disintegrin Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADAM Type Metalloprotease Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAM8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Disintegrin and Metalloproteinase Domain-Containing Protein 8&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;ADAM Family Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Disintegrin Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADAM Type Metalloprotease Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAM8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90313</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase Parkin</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase Parkin&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Parkinson&apos;s Disease&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Death Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PARK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase Parkin&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Parkinson&apos;s Disease&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Death Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PARK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C60309</classIRI>
<classLabel>Glutathione Peroxidase 1</classLabel>
<deletedAxiom>&apos;Glutathione Peroxidase 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glutathione Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Flumazenil Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hemolytic Anemia&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPX1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Glutathione Peroxidase 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glutathione Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Flumazenil Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hemolytic Anemia&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPX1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105525</classIRI>
<classLabel>RET Gene Product</classLabel>
<deletedAxiom>&apos;RET Gene Product&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90573</classIRI>
<classLabel>JAK2 Inhibitor XL019</classLabel>
<deletedAxiom>&apos;JAK2 Inhibitor XL019&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;JAK2 Inhibitor XL019&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125450</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105734</classIRI>
<classLabel>Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase Subunit DAD1</classLabel>
<deletedAxiom>&apos;Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase Subunit DAD1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Glycan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Glycosylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Death&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DAD1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase Subunit DAD1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Glycan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Glycosylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Death&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DAD1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105905</classIRI>
<classLabel>Cytochrome P450 2A6</classLabel>
<deletedAxiom>&apos;Cytochrome P450 2A6&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caffeine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2A6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 2A6&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caffeine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2A6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105831</classIRI>
<classLabel>Peptidyl-Prolyl Cis-Trans Isomerase FKBP5</classLabel>
<deletedAxiom>&apos;Peptidyl-Prolyl Cis-Trans Isomerase FKBP5&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glucocorticoid Receptor Regulatory Network&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;FK506 Binding Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Isomerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FKBP5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Peptidyl-Prolyl Cis-Trans Isomerase FKBP5&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glucocorticoid Receptor Regulatory Network&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;FK506 Binding Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FKBP5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101409</classIRI>
<classLabel>Tolloid-Like Protein 1</classLabel>
<deletedAxiom>&apos;Tolloid-Like Protein 1&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Cleavage&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TLL1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tolloid-Like Protein 1&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Cleavage&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TLL1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101415</classIRI>
<classLabel>Activation-Induced Cytidine Deaminase</classLabel>
<deletedAxiom>&apos;Activation-Induced Cytidine Deaminase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymph Node Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Tonsillar Tissue&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Differentiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AICDA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Activation-Induced Cytidine Deaminase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymph Node Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Tonsillar Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Differentiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AICDA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101421</classIRI>
<classLabel>Probable ATP-Dependent RNA Helicase DDX58</classLabel>
<deletedAxiom>&apos;Probable ATP-Dependent RNA Helicase DDX58&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytosolic DNA-Sensing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Helicase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunity&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antiviral Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDX58 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Probable ATP-Dependent RNA Helicase DDX58&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytosolic DNA-Sensing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunity&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antiviral Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDX58 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39671</classIRI>
<classLabel>Dual Specificity Protein Phosphatase 22</classLabel>
<deletedAxiom>&apos;Dual Specificity Protein Phosphatase 22&apos; EquivalentTo &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Dual-Specificity Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DUSP22 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dual Specificity Protein Phosphatase 22&apos; EquivalentTo &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DUSP22 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101337</classIRI>
<classLabel>2-5A-Dependent Ribonuclease</classLabel>
<deletedAxiom>&apos;2-5A-Dependent Ribonuclease&apos; EquivalentTo &apos;Endoribonuclease&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Binding Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Endoribonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antiviral Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Interferon Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNASEL Gene&apos;)</deletedAxiom>
<newAxiom>&apos;2-5A-Dependent Ribonuclease&apos; EquivalentTo &apos;Endoribonuclease&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antiviral Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Interferon Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNASEL Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101361</classIRI>
<classLabel>Rho GTPase-Activating Protein 29</classLabel>
<deletedAxiom>&apos;Rho GTPase-Activating Protein 29&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase-Activating Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101358</classIRI>
<classLabel>PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 1</classLabel>
<deletedAxiom>&apos;PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 1&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Serine/Threonine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PHLPP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 1&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PHLPP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101394</classIRI>
<classLabel>Steroid Hormone Receptor ERR1</classLabel>
<deletedAxiom>&apos;Steroid Hormone Receptor ERR1&apos; EquivalentTo &apos;Steroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Hormone Receptor DNA-Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Nuclear Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Sequence-Specific DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ESRRA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Steroid Hormone Receptor ERR1&apos; EquivalentTo &apos;Steroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PGC1a Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Hormone Receptor DNA-Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Sequence-Specific DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ESRRA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101557</classIRI>
<classLabel>Galactoside-Binding Soluble Lectin 13</classLabel>
<deletedAxiom>&apos;Galactoside-Binding Soluble Lectin 13&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phospholipase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101561</classIRI>
<classLabel>Serine/Threonine-Protein Kinase Sgk1</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase Sgk1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Class I PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXO Transcription Factor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glucocorticoid Receptor Regulatory Network&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Stress Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Cell Death Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SGK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase Sgk1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Class I PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXO Transcription Factor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glucocorticoid Receptor Regulatory Network&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway PID&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Stress Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Cell Death Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SGK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101567</classIRI>
<classLabel>ATP-Dependent RNA Helicase DDX3X</classLabel>
<deletedAxiom>&apos;ATP-Dependent RNA Helicase DDX3X&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Helicase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDX3X Gene&apos;)</deletedAxiom>
<newAxiom>&apos;ATP-Dependent RNA Helicase DDX3X&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDX3X Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101564</classIRI>
<classLabel>NAD-Dependent Deacetylase Sirtuin-2</classLabel>
<deletedAxiom>&apos;NAD-Dependent Deacetylase Sirtuin-2&apos; EquivalentTo &apos;Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class III Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoskeleton&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Microtubule&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Deacetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deacetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SIRT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NAD-Dependent Deacetylase Sirtuin-2&apos; EquivalentTo &apos;Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class III Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoskeleton&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Microtubule&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deacetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SIRT2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101570</classIRI>
<classLabel>SUMO-Activating Enzyme Subunit 2</classLabel>
<deletedAxiom>&apos;SUMO-Activating Enzyme Subunit 2&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBA2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SUMO-Activating Enzyme Subunit 2&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBA2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101573</classIRI>
<classLabel>SUMO-Activating Enzyme Subunit 1</classLabel>
<deletedAxiom>&apos;SUMO-Activating Enzyme Subunit 1&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endoplasmic Reticulum Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SAE1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SUMO-Activating Enzyme Subunit 1&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endoplasmic Reticulum Degradation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SAE1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101545</classIRI>
<classLabel>Egl Nine Homolog 1</classLabel>
<deletedAxiom>&apos;Egl Nine Homolog 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Stress Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EGLN1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Egl Nine Homolog 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Stress Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EGLN1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101548</classIRI>
<classLabel>Non-Receptor Tyrosine-Protein Kinase TYK2</classLabel>
<deletedAxiom>&apos;Non-Receptor Tyrosine-Protein Kinase TYK2&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN Alpha Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL22 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NO2-Dependent IL12 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stat3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL23-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL27-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Induction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Interferon Signaling Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Induction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Non-Receptor Tyrosine-Protein Kinase TYK2&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN Alpha Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL22 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NO2-Dependent IL12 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stat3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL23-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL27-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Induction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Interferon Signaling Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Induction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101551</classIRI>
<classLabel>Prolyl 4-Hydroxylase Subunit Alpha-2</classLabel>
<deletedAxiom>&apos;Prolyl 4-Hydroxylase Subunit Alpha-2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Procollagen-Proline Dioxygenase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;P4HA2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Prolyl 4-Hydroxylase Subunit Alpha-2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Procollagen-Proline Dioxygenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;P4HA2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101486</classIRI>
<classLabel>Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5</classLabel>
<deletedAxiom>&apos;Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LGR5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LGR5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101483</classIRI>
<classLabel>Gamma-Aminobutyric Acid Type B Receptor Subunit 2</classLabel>
<deletedAxiom>&apos;Gamma-Aminobutyric Acid Type B Receptor Subunit 2&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Postsynaptic Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GABBR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Gamma-Aminobutyric Acid Type B Receptor Subunit 2&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Postsynaptic Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GABBR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101460</classIRI>
<classLabel>Microtubule-Associated Serine/Threonine-Protein Kinase 2</classLabel>
<deletedAxiom>&apos;Microtubule-Associated Serine/Threonine-Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoskeleton&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Spermatogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Communication Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAST2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Microtubule-Associated Serine/Threonine-Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoskeleton&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Spermatogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Communication Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAST2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101457</classIRI>
<classLabel>Microtubule-Associated Serine/Threonine-Protein Kinase 1</classLabel>
<deletedAxiom>&apos;Microtubule-Associated Serine/Threonine-Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoskeleton&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Communication Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAST1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Microtubule-Associated Serine/Threonine-Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoskeleton&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Communication Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAST1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101657</classIRI>
<classLabel>Regulator of G-Protein Signaling 4</classLabel>
<deletedAxiom>&apos;Regulator of G-Protein Signaling 4&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase-Activating Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 4&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101610</classIRI>
<classLabel>Denticleless Protein Homolog</classLabel>
<deletedAxiom>&apos;Denticleless Protein Homolog&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centrosome&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Monoubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DTL Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Denticleless Protein Homolog&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centrosome&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Monoubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DTL Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101613</classIRI>
<classLabel>Sharpin</classLabel>
<deletedAxiom>&apos;Sharpin&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunoregulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Necrosis Factor Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SHARPIN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Sharpin&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunoregulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Necrosis Factor Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SHARPIN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101631</classIRI>
<classLabel>Growth Arrest-Specific Protein 6</classLabel>
<deletedAxiom>&apos;Growth Arrest-Specific Protein 6&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Extracellular Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Leukocyte Trafficking Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GAS6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Growth Arrest-Specific Protein 6&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Extracellular Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Leukocyte Trafficking Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GAS6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101604</classIRI>
<classLabel>Ribonuclease Inhibitor</classLabel>
<deletedAxiom>&apos;Ribonuclease Inhibitor&apos; EquivalentTo &apos;Enzyme Inhibitor Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Enzyme Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNH1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ribonuclease Inhibitor&apos; EquivalentTo &apos;Enzyme Inhibitor Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNH1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101585</classIRI>
<classLabel>G/T Mismatch-Specific Thymine DNA Glycosylase</classLabel>
<deletedAxiom>&apos;G/T Mismatch-Specific Thymine DNA Glycosylase&apos; EquivalentTo &apos;Hydrolase&apos; and &apos;DNA Repair Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Base Excision Repair Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Repair Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mismatch Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TDG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G/T Mismatch-Specific Thymine DNA Glycosylase&apos; EquivalentTo &apos;Hydrolase&apos; and &apos;DNA Repair Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Base Excision Repair Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mismatch Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TDG Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101579</classIRI>
<classLabel>C-C Chemokine Receptor Type 2</classLabel>
<deletedAxiom>&apos;C-C Chemokine Receptor Type 2&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chemokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chemotactic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Receptor Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Defense Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;C-C Chemokine Receptor Type 2&apos; EquivalentTo &apos;Chemokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chemotactic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Receptor Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Defense Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101720</classIRI>
<classLabel>Serine Protease Hepsin</classLabel>
<deletedAxiom>&apos;Serine Protease Hepsin&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Scavenger Receptor Cysteine-Rich Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Cell Size&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HPN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine Protease Hepsin&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Scavenger Receptor Cysteine-Rich Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Cell Size&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HPN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39275</classIRI>
<classLabel>Interleukin-3 Receptor Subunit Alpha</classLabel>
<deletedAxiom>&apos;Interleukin-3 Receptor Subunit Alpha&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL3RA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interleukin-3 Receptor Subunit Alpha&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL3RA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39272</classIRI>
<classLabel>Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha</classLabel>
<deletedAxiom>&apos;Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha&apos; EquivalentTo &apos;Colony Stimulating Factor Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Cell Activation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CSF2RA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha&apos; EquivalentTo &apos;Colony Stimulating Factor Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Cell Activation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CSF2RA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101097</classIRI>
<classLabel>Cyclin-Dependent Kinase 12</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 12&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101106</classIRI>
<classLabel>F-Box Only Protein 11</classLabel>
<deletedAxiom>&apos;F-Box Only Protein 11&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;F-Box Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FBXO11 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;F-Box Only Protein 11&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;F-Box Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FBXO11 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101311</classIRI>
<classLabel>Serine Protease HTRA1</classLabel>
<deletedAxiom>&apos;Serine Protease HTRA1&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Extracellular Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HTRA1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine Protease HTRA1&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Extracellular Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HTRA1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101303</classIRI>
<classLabel>Ubiquitin-Conjugating Enzyme E2 R1</classLabel>
<deletedAxiom>&apos;Ubiquitin-Conjugating Enzyme E2 R1&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin E Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F1 Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDC34 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ubiquitin-Conjugating Enzyme E2 R1&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin E Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F1 Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDC34 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118185</classIRI>
<classLabel>C4d</classLabel>
<deletedAxiom>&apos;C4d&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Complement Component Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98004</classIRI>
<classLabel>Hyaluronan Synthase 2</classLabel>
<deletedAxiom>&apos;Hyaluronan Synthase 2&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Glycosylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HAS2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Hyaluronan Synthase 2&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Glycosylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HAS2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101803</classIRI>
<classLabel>F2 Gene Product</classLabel>
<deletedAxiom>&apos;F2 Gene Product&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Coagulation Factor&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101804</classIRI>
<classLabel>Des-Gamma Carboxyprothrombin</classLabel>
<deletedAxiom>&apos;Des-Gamma Carboxyprothrombin&apos; EquivalentTo &apos;F2 Gene Product&apos; and (&apos;Gene_Product_Is_Biomarker_Of&apos; some &apos;Hepatocellular Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Coagulation Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;F2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Des-Gamma Carboxyprothrombin&apos; EquivalentTo &apos;F2 Gene Product&apos; and (&apos;Gene_Product_Is_Biomarker_Of&apos; some &apos;Hepatocellular Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;F2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118565</classIRI>
<classLabel>Carbonyl Reductase [NADPH] 1</classLabel>
<deletedAxiom>&apos;Carbonyl Reductase [NADPH] 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Exosome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Eicosanoid Modulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Metabolism Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CBR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Carbonyl Reductase [NADPH] 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Exosome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Eicosanoid Modulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Metabolism Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CBR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118599</classIRI>
<classLabel>Arf-GAP with SH3 Domain, Ankyrin Repeat and PH Domain 1</classLabel>
<deletedAxiom>&apos;Arf-GAP with SH3 Domain, Ankyrin Repeat and PH Domain 1&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase-Activating Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ASAP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Arf-GAP with SH3 Domain, Ankyrin Repeat and PH Domain 1&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ASAP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118477</classIRI>
<classLabel>G1/S-Specific Cyclin-D1b</classLabel>
<deletedAxiom>&apos;G1/S-Specific Cyclin-D1b&apos; EquivalentTo &apos;CCND1 Gene Product&apos; and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Protein Truncation Abnormality&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stimulation of Cancer Cell Growth&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Invasion&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCND1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G1/S-Specific Cyclin-D1b&apos; EquivalentTo &apos;CCND1 Gene Product&apos; and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Protein Truncation Abnormality&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stimulation of Cancer Cell Growth&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Invasion&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCND1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118495</classIRI>
<classLabel>CD45RO</classLabel>
<deletedAxiom>&apos;CD45RO&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118492</classIRI>
<classLabel>CD45RA</classLabel>
<deletedAxiom>&apos;CD45RA&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118494</classIRI>
<classLabel>CD45RC</classLabel>
<deletedAxiom>&apos;CD45RC&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118493</classIRI>
<classLabel>CD45RB</classLabel>
<deletedAxiom>&apos;CD45RB&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73561</classIRI>
<classLabel>Bone Morphogenetic Protein Receptor Type-1B</classLabel>
<deletedAxiom>&apos;Bone Morphogenetic Protein Receptor Type-1B&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BMPR1B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Bone Morphogenetic Protein Receptor Type-1B&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BMPR1B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118357</classIRI>
<classLabel>Probable ATP-Dependent RNA Helicase DDX20</classLabel>
<deletedAxiom>&apos;Probable ATP-Dependent RNA Helicase DDX20&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Helicase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Splicing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDX20 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Probable ATP-Dependent RNA Helicase DDX20&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Splicing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDX20 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73448</classIRI>
<classLabel>Proteasome Subunit Beta Type-9</classLabel>
<deletedAxiom>&apos;Proteasome Subunit Beta Type-9&apos; EquivalentTo &apos;Peptidase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proteasome Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PSMB9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Proteasome Subunit Beta Type-9&apos; EquivalentTo &apos;Peptidase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proteasome Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Endopeptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PSMB9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73466</classIRI>
<classLabel>Serine/Threonine-Protein Kinase LMTK2</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase LMTK2&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17018</classIRI>
<classLabel>Protein Kinase</classLabel>
<deletedAxiom>&apos;Protein Kinase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113109</classIRI>
<classLabel>Ubiquitin-Associated and SH3 Domain-Containing Protein B</classLabel>
<deletedAxiom>&apos;Ubiquitin-Associated and SH3 Domain-Containing Protein B&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBASH3B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ubiquitin-Associated and SH3 Domain-Containing Protein B&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBASH3B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113142</classIRI>
<classLabel>MORC Family CW-Type Zinc Finger Protein 3</classLabel>
<deletedAxiom>&apos;MORC Family CW-Type Zinc Finger Protein 3&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nuclear Matrix&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Aging&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metal Ion Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MORC3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;MORC Family CW-Type Zinc Finger Protein 3&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nuclear Matrix&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Metal Binding Site&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Aging&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metal Ion Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MORC3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106408</classIRI>
<classLabel>Non-Receptor Type Protein Tyrosine Phosphatase</classLabel>
<deletedAxiom>&apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;</deletedAxiom>
<newAxiom>&apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113272</classIRI>
<classLabel>Endothelial Lipase</classLabel>
<deletedAxiom>&apos;Endothelial Lipase&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Esterase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LIPG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Endothelial Lipase&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Lipase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cholesterol Homeostasis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LIPG Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106330</classIRI>
<classLabel>Type II Inositol 3,4-Bisphosphate 4-Phosphatase</classLabel>
<deletedAxiom>&apos;Type II Inositol 3,4-Bisphosphate 4-Phosphatase&apos; EquivalentTo &apos;Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;INPP4B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Type II Inositol 3,4-Bisphosphate 4-Phosphatase&apos; EquivalentTo &apos;Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phospholipid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;INPP4B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113083</classIRI>
<classLabel>MAP Kinase-Activated Protein Kinase 5</classLabel>
<deletedAxiom>&apos;MAP Kinase-Activated Protein Kinase 5&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Induction of Cell Senescence&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPKAPK5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;MAP Kinase-Activated Protein Kinase 5&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Induction of Cell Senescence&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPKAPK5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98060</classIRI>
<classLabel>Transient Receptor Potential Cation Channel Subfamily M Member 7</classLabel>
<deletedAxiom>&apos;Transient Receptor Potential Cation Channel Subfamily M Member 7&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Ion Channel Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cellular Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ion Transport Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Cell Death Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRPM7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Transient Receptor Potential Cation Channel Subfamily M Member 7&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Ion Channel Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cellular Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ion Transport Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Cell Death Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRPM7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113607</classIRI>
<classLabel>Histone Deacetylase 8</classLabel>
<deletedAxiom>&apos;Histone Deacetylase 8&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Deacetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Developmental Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Deacetylase 8&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Developmental Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98089</classIRI>
<classLabel>LDLR Chaperone MESD</classLabel>
<deletedAxiom>&apos;LDLR Chaperone MESD&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chaperone&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17411</classIRI>
<classLabel>Fibroblast Growth Factor Receptor 2</classLabel>
<deletedAxiom>&apos;Fibroblast Growth Factor Receptor 2&apos; EquivalentTo &apos;FGFR2 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Bone Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Cartilaginous Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Organogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Epithelial Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGFR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fibroblast Growth Factor Receptor 2&apos; EquivalentTo &apos;FGFR2 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Bone Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Cartilaginous Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Organogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Epithelial Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGFR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17416</classIRI>
<classLabel>RHOC Protein</classLabel>
<deletedAxiom>&apos;RHOC Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Small G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RHOC Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17415</classIRI>
<classLabel>Transforming Protein RHOA</classLabel>
<deletedAxiom>&apos;Transforming Protein RHOA&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Small G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Transforming Protein RHOA&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98109</classIRI>
<classLabel>JAK2/Src Inhibitor NS-018</classLabel>
<deletedAxiom>&apos;JAK2/Src Inhibitor NS-018&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;JAK2/Src Inhibitor NS-018&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125450</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17408</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 3</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 3&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pain Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1R Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pelp1 Estrogen Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Splicing Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stat3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Differentiation in the Thymus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 3&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pain Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1R Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pelp1 Estrogen Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Splicing Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stat3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Differentiation in the Thymus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17406</classIRI>
<classLabel>Endoglin</classLabel>
<deletedAxiom>&apos;Endoglin&apos; EquivalentTo &apos;Growth Factor Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;TGF-Beta Receptor Type-2&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Growth Factor Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ENG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Endoglin&apos; EquivalentTo &apos;Growth Factor Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;TGF-Beta Receptor Type-2&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ENG Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17458</classIRI>
<classLabel>G Protein</classLabel>
<deletedAxiom>&apos;G Protein&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17444</classIRI>
<classLabel>Protein Tyrosine Phosphatase</classLabel>
<deletedAxiom>&apos;Protein Tyrosine Phosphatase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98119</classIRI>
<classLabel>NEDD4-Like E3 Ubiquitin-Protein Ligase WWP1</classLabel>
<deletedAxiom>&apos;NEDD4-Like E3 Ubiquitin-Protein Ligase WWP1&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WWP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NEDD4-Like E3 Ubiquitin-Protein Ligase WWP1&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WWP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17428</classIRI>
<classLabel>Glucose-6-Phosphate Isomerase</classLabel>
<deletedAxiom>&apos;Glucose-6-Phosphate Isomerase&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycolysis/Gluconeogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amino and Nucleotide Sugars Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pentose Phosphate Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Starch and Sucrose Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycolysis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Isomerase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Neurotrophic Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Lymphokine&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gluconeogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Glycolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPI Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Glucose-6-Phosphate Isomerase&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycolysis/Gluconeogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amino and Nucleotide Sugars Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pentose Phosphate Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Starch and Sucrose Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycolysis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Neurotrophic Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Lymphokine&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gluconeogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Glycolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPI Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113597</classIRI>
<classLabel>Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4</classLabel>
<deletedAxiom>&apos;Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Translation Process Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EIF2AK4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Translation Process Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EIF2AK4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17483</classIRI>
<classLabel>Tyrosine-Protein Kinase Fgr</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Fgr&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Fgr&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17485</classIRI>
<classLabel>Vitamin D3 Receptor</classLabel>
<deletedAxiom>&apos;Vitamin D3 Receptor&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Expression Regulation by Vitamin D Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinoic Acid Receptor Family-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Differentiation Antigen&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Nuclear Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tissue Growth&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;VDR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Vitamin D3 Receptor&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Expression Regulation by Vitamin D Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinoic Acid Receptor Family-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Differentiation Antigen&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tissue Growth&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;VDR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17484</classIRI>
<classLabel>RAF Proto-Oncogene Serine/Threonine-Protein Kinase</classLabel>
<deletedAxiom>&apos;RAF Proto-Oncogene Serine/Threonine-Protein Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1R Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Cysteine-Rich Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAF1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAF Proto-Oncogene Serine/Threonine-Protein Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1R Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Cysteine-Rich Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAF1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17475</classIRI>
<classLabel>Tyrosine-Protein Kinase Receptor UFO</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Receptor UFO&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Protein Deregulation&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AXL Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Receptor UFO&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Protein Deregulation&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AXL Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17472</classIRI>
<classLabel>Acylamino-Acid-Releasing Enzyme</classLabel>
<deletedAxiom>&apos;Acylamino-Acid-Releasing Enzyme&apos; EquivalentTo &apos;Peptidase&apos; and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Peptide Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;APEH Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Acylamino-Acid-Releasing Enzyme&apos; EquivalentTo &apos;Peptidase&apos; and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Peptide Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;APEH Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17470</classIRI>
<classLabel>Telomerase</classLabel>
<deletedAxiom>&apos;Telomerase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Reverse Transcriptase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106026</classIRI>
<classLabel>Dual Specificity Protein Phosphatase 6</classLabel>
<deletedAxiom>&apos;Dual Specificity Protein Phosphatase 6&apos; EquivalentTo &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DUSP6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dual Specificity Protein Phosphatase 6&apos; EquivalentTo &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DUSP6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106063</classIRI>
<classLabel>Serine/Threonine-Protein Kinase Nek9</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase Nek9&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Segregation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NEK9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase Nek9&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Segregation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NEK9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98163</classIRI>
<classLabel>Tripartite Motif-Containing Protein 5</classLabel>
<deletedAxiom>&apos;Tripartite Motif-Containing Protein 5&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;TRIM Family&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;TRIM Motif&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antiviral Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIM5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tripartite Motif-Containing Protein 5&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;TRIM Family&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;TRIM Motif&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antiviral Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIM5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106082</classIRI>
<classLabel>Rho-Related GTP-Binding Protein RhoJ</classLabel>
<deletedAxiom>&apos;Rho-Related GTP-Binding Protein RhoJ&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Small G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOJ Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Rho-Related GTP-Binding Protein RhoJ&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOJ Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98205</classIRI>
<classLabel>SAM Domain and HD Domain-Containing Protein 1</classLabel>
<deletedAxiom>&apos;SAM Domain and HD Domain-Containing Protein 1&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SAM Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Esterase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunity&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antiviral Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SAMHD1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SAM Domain and HD Domain-Containing Protein 1&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SAM Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunity&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antiviral Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SAMHD1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17319</classIRI>
<classLabel>Receptor Tyrosine-Protein Kinase erbB-2</classLabel>
<deletedAxiom>&apos;Receptor Tyrosine-Protein Kinase erbB-2&apos; EquivalentTo &apos;ERBB2 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Family Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;ERBB2 Protein Overexpression&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ERBB2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor Tyrosine-Protein Kinase erbB-2&apos; EquivalentTo &apos;ERBB2 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Family Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;ERBB2 Protein Overexpression&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ERBB2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17312</classIRI>
<classLabel>Mineralocorticoid Receptor</classLabel>
<deletedAxiom>&apos;Mineralocorticoid Receptor&apos; EquivalentTo &apos;Steroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Steroid Hormone Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR3C2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mineralocorticoid Receptor&apos; EquivalentTo &apos;Steroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR3C2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17314</classIRI>
<classLabel>Nucleoside Diphosphate Kinase A</classLabel>
<deletedAxiom>&apos;Nucleoside Diphosphate Kinase A&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Vesicle Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Granzyme A Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Trafficking Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Formation Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Kinase&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Neuroblastoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NME1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Nucleoside Diphosphate Kinase A&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Vesicle Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Granzyme A Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Trafficking Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Formation Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Kinase&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Neuroblastoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NME1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17315</classIRI>
<classLabel>Methylated-DNA-Protein-Cysteine Methyltransferase</classLabel>
<deletedAxiom>&apos;Methylated-DNA-Protein-Cysteine Methyltransferase&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Marker&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Retinoblastoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MGMT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Methylated-DNA-Protein-Cysteine Methyltransferase&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Marker&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Retinoblastoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MGMT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17311</classIRI>
<classLabel>Methylenetetrahydrofolate Reductase</classLabel>
<deletedAxiom>&apos;Methylenetetrahydrofolate Reductase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;One Carbon Pool by Folate Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Folic Acid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MTHFR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Methylenetetrahydrofolate Reductase&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MTHFR Gene&apos;</newAxiom>
<newAxiom>&apos;Methylenetetrahydrofolate Reductase&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Folic Acid Metabolic Process&apos;</newAxiom>
<newAxiom>&apos;Methylenetetrahydrofolate Reductase&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;One Carbon Pool by Folate Pathway&apos;</newAxiom>
<newAxiom>&apos;Methylenetetrahydrofolate Reductase&apos; SubClassOf &apos;Oxidoreductase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17309</classIRI>
<classLabel>Tyrosine-Protein Kinase Lck</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Lck&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Co-Stimulatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TCR Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Atypical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LCK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Lck&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Co-Stimulatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TCR Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Atypical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LCK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17331</classIRI>
<classLabel>RHOB Protein</classLabel>
<deletedAxiom>&apos;RHOB Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Small G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RHOB Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17325</classIRI>
<classLabel>Serine/Threonine Protein Kinase</classLabel>
<deletedAxiom>&apos;Serine/Threonine Protein Kinase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17326</classIRI>
<classLabel>Tyrosine-Protein Kinase Lyn</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Lyn&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Aggregation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphoinositide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunoglobulin-Mediated Cell Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LYN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Lyn&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Aggregation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphoinositide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunoglobulin-Mediated Cell Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LYN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17323</classIRI>
<classLabel>Proliferating Cell Nuclear Antigen</classLabel>
<deletedAxiom>&apos;Proliferating Cell Nuclear Antigen&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Proliferation Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Repair Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PCNA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Proliferating Cell Nuclear Antigen&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Proliferation Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Repair Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PCNA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17327</classIRI>
<classLabel>Proto-Oncogene Serine/Threonine-Protein Kinase mos</classLabel>
<deletedAxiom>&apos;Proto-Oncogene Serine/Threonine-Protein Kinase mos&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Spermatogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MOS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Proto-Oncogene Serine/Threonine-Protein Kinase mos&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Spermatogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MOS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17328</classIRI>
<classLabel>Mast/Stem Cell Growth Factor Receptor Kit</classLabel>
<deletedAxiom>&apos;Mast/Stem Cell Growth Factor Receptor Kit&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Gastrointestinal Stromal Tumor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KIT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mast/Stem Cell Growth Factor Receptor Kit&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Gastrointestinal Stromal Tumor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KIT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17341</classIRI>
<classLabel>TGF-Beta Receptor Type-2</classLabel>
<deletedAxiom>&apos;TGF-Beta Receptor Type-2&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lynch Syndrome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Serine/Threonine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TGFBR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;TGF-Beta Receptor Type-2&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lynch Syndrome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TGFBR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17349</classIRI>
<classLabel>Cyclin</classLabel>
<deletedAxiom>&apos;Cyclin&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17394</classIRI>
<classLabel>Retinoblastoma-Associated Protein</classLabel>
<deletedAxiom>&apos;Retinoblastoma-Associated Protein&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ribosomal Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BTG Cell Cycle Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin E Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F1 Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Terc Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon Signaling Modulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Phosphoprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Is_Biomarker_Of&apos; some &apos;Retinoblastoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Repressor/Corepressor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RB1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Retinoblastoma-Associated Protein&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ribosomal Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BTG Cell Cycle Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin E Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F1 Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Terc Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon Signaling Modulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Phosphoprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Is_Biomarker_Of&apos; some &apos;Retinoblastoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Repressor/Corepressor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RB1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17392</classIRI>
<classLabel>Macrophage Colony-Stimulating Factor 1 Receptor</classLabel>
<deletedAxiom>&apos;Macrophage Colony-Stimulating Factor 1 Receptor&apos; EquivalentTo &apos;Colony Stimulating Factor Receptor&apos; and &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CSF1R Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Macrophage Colony-Stimulating Factor 1 Receptor&apos; EquivalentTo &apos;Colony Stimulating Factor Receptor&apos; and &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CSF1R Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17389</classIRI>
<classLabel>Proto-Oncogene Tyrosine-Protein Kinase Src</classLabel>
<deletedAxiom>&apos;Proto-Oncogene Tyrosine-Protein Kinase Src&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell to Cell Adhesion Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GABA Receptor Life Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HBx Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pelp1 Estrogen Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rho Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Splicing Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRC Tyrosine Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-1 Cell Spread Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Atypical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E-Cadherin Signaling Pathway in Keratinocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endothelin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nectin Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTP4A Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SRC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Proto-Oncogene Tyrosine-Protein Kinase Src&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell to Cell Adhesion Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GABA Receptor Life Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HBx Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pelp1 Estrogen Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rho Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Splicing Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRC Tyrosine Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-1 Cell Spread Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Atypical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E-Cadherin Signaling Pathway in Keratinocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endothelin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nectin Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTP4A Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/PI3K/PLC-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SRC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17386</classIRI>
<classLabel>Cyclin-Dependent Kinase 1</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 1&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDC25 and CHK1 Regulatory Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ptc1 Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Splicing Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRC Tyrosine Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Proliferation Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;M-Phase Promoting Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 1&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Centrosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDC25 and CHK1 Regulatory Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ptc1 Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Splicing Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRC Tyrosine Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Proliferation Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;M-Phase Promoting Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17382</classIRI>
<classLabel>p21 H-Ras Protein</classLabel>
<deletedAxiom>&apos;p21 H-Ras Protein&apos; EquivalentTo &apos;p21 RAS Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HBx Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1R Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Longevity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Splicing Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Trka Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Small G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HRAS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;p21 H-Ras Protein&apos; EquivalentTo &apos;p21 RAS Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HBx Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1R Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Longevity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Splicing Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Trka Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HRAS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17383</classIRI>
<classLabel>p21 K-Ras Protein</classLabel>
<deletedAxiom>&apos;p21 K-Ras Protein&apos; EquivalentTo &apos;p21 RAS Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Small G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KRAS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;p21 K-Ras Protein&apos; EquivalentTo &apos;p21 RAS Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KRAS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17384</classIRI>
<classLabel>p21 N-Ras Protein</classLabel>
<deletedAxiom>&apos;p21 N-Ras Protein&apos; EquivalentTo &apos;p21 RAS Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Small G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NRAS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;p21 N-Ras Protein&apos; EquivalentTo &apos;p21 RAS Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NRAS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17390</classIRI>
<classLabel>Tyrosine-Protein Kinase ABL1</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase ABL1&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ribosomal Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LIS1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lissencephaly-1 Gene in Neuronal Migration and Development&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ABL1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase ABL1&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ribosomal Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LIS1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lissencephaly-1 Gene in Neuronal Migration and Development&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ABL1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17190</classIRI>
<classLabel>3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2</classLabel>
<deletedAxiom>&apos;3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Prostate Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Enzyme&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Androgen Metabolism Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SRD5A2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Prostate Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Androgen Metabolism Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SRD5A2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17191</classIRI>
<classLabel>Dihydrofolate Reductase</classLabel>
<deletedAxiom>&apos;Dihydrofolate Reductase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Folate Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;One Carbon Pool by Folate Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DHFR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dihydrofolate Reductase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Folate Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;One Carbon Pool by Folate Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DHFR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17199</classIRI>
<classLabel>Thymidylate Synthase</classLabel>
<deletedAxiom>&apos;Thymidylate Synthase&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Folate Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;One Carbon Pool by Folate Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Disease Marker&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYMS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Thymidylate Synthase&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Folate Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;One Carbon Pool by Folate Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Disease Marker&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYMS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17198</classIRI>
<classLabel>Thymidine Kinase</classLabel>
<deletedAxiom>&apos;Thymidine Kinase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17210</classIRI>
<classLabel>Transferase</classLabel>
<deletedAxiom>&apos;Transferase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Enzyme&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17218</classIRI>
<classLabel>Tryptophan 2,3-Dioxygenase</classLabel>
<deletedAxiom>&apos;Tryptophan 2,3-Dioxygenase&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxygenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Catabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TDO2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tryptophan 2,3-Dioxygenase&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Metabolism Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Catabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TDO2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17296</classIRI>
<classLabel>Cytochrome P450 1A1</classLabel>
<deletedAxiom>&apos;Cytochrome P450 1A1&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Risk Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Is_Biomarker_Of&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carcinogen Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP1A1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 1A1&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Risk Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Is_Biomarker_Of&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carcinogen Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP1A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17290</classIRI>
<classLabel>Dihydropyrimidine Dehydrogenase [NADP(+)]</classLabel>
<deletedAxiom>&apos;Dihydropyrimidine Dehydrogenase [NADP(+)]&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Alanine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pantothenate and CoA Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Disease Marker&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Catabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DPYD Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dihydropyrimidine Dehydrogenase [NADP(+)]&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Alanine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pantothenate and CoA Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Disease Marker&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Catabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DPYD Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17282</classIRI>
<classLabel>Receptor-Type Tyrosine-Protein Phosphatase C</classLabel>
<deletedAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase C&apos; EquivalentTo &apos;PTPRC Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TCR Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytotoxic T Cell Surface Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Helper Cell Surface Molecule Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Lymphocyte Cell Surface Molecule Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Adhesion Molecule Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Multiple Sclerosis&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Type Tyrosine-Protein Phosphatase C&apos; EquivalentTo &apos;PTPRC Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TCR Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytotoxic T Cell Surface Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Helper Cell Surface Molecule Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Lymphocyte Cell Surface Molecule Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Adhesion Molecule Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Multiple Sclerosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPRC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17287</classIRI>
<classLabel>Cytochrome P450 2D6</classLabel>
<deletedAxiom>&apos;Cytochrome P450 2D6&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2D6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 2D6&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2D6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17289</classIRI>
<classLabel>Dihydroorotate Dehydrogenase (Quinone), Mitochondrial</classLabel>
<deletedAxiom>&apos;Dihydroorotate Dehydrogenase (Quinone), Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Inner Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DHODH Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dihydroorotate Dehydrogenase (Quinone), Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Inner Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DHODH Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17242</classIRI>
<classLabel>Urokinase-Type Plasminogen Activator</classLabel>
<deletedAxiom>&apos;Urokinase-Type Plasminogen Activator&apos; EquivalentTo &apos;Plasminogen Activator&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fibrinolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Amyloid Precursor Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Metastasis and Aggressiveness Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Blood&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Urine&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Kringle Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Plasminogen Activator&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Coagulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLAU Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Urokinase-Type Plasminogen Activator&apos; EquivalentTo &apos;Plasminogen Activator&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fibrinolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Amyloid Precursor Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Metastasis and Aggressiveness Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Blood&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Urine&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Kringle Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Coagulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLAU Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17227</classIRI>
<classLabel>Ubiquitin</classLabel>
<deletedAxiom>&apos;Ubiquitin&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17226</classIRI>
<classLabel>Tyrosinase</classLabel>
<deletedAxiom>&apos;Tyrosinase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Riboflavin Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tyrosine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Melanogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosinase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Riboflavin Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tyrosine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Melanogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17063</classIRI>
<classLabel>Androgen Receptor</classLabel>
<deletedAxiom>&apos;Androgen Receptor&apos; EquivalentTo &apos;Steroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Differentiation Antigen&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Hormone Receptor DNA-Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gene Expression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Androgen Receptor&apos; EquivalentTo &apos;Steroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Differentiation Antigen&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Hormone Receptor DNA-Binding Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gene Expression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17069</classIRI>
<classLabel>Estrogen Receptor Family</classLabel>
<deletedAxiom>&apos;Estrogen Receptor Family&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;</deletedAxiom>
<deletedAxiom>&apos;Estrogen Receptor Family&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Steroid Hormone Receptor&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17068</classIRI>
<classLabel>Epidermal Growth Factor Receptor</classLabel>
<deletedAxiom>&apos;Epidermal Growth Factor Receptor&apos; EquivalentTo &apos;EGFR Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vesicle Transport Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Map Kinase Inactivation of SMRT Corepressor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ErbB3 Receptor Recycling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dorso-Ventral Axis Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E-Cadherin Signaling Pathway in Keratinocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGFR-Dependent Endothelin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Family Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Stabilization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell-Cell Adhesion Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EGFR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Epidermal Growth Factor Receptor&apos; EquivalentTo &apos;EGFR Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vesicle Transport Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Map Kinase Inactivation of SMRT Corepressor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ErbB3 Receptor Recycling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dorso-Ventral Axis Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E-Cadherin Signaling Pathway in Keratinocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGFR-Dependent Endothelin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Family Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Stabilization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell-Cell Adhesion Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EGFR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17071</classIRI>
<classLabel>Glucocorticoid Receptor</classLabel>
<deletedAxiom>&apos;Glucocorticoid Receptor&apos; EquivalentTo &apos;Steroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Corticosteroid Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;hSWI-SNF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN-Beta Enhancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chromatin Remodeling Complex and Coactivator Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Polymerase III Transcription Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolic Syndrome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA2 and FOXA3 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glucocorticoid Receptor Regulatory Network&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Nuclear Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR3C1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Glucocorticoid Receptor&apos; EquivalentTo &apos;Steroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Corticosteroid Cardioprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;hSWI-SNF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN-Beta Enhancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chromatin Remodeling Complex and Coactivator Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Polymerase III Transcription Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolic Syndrome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA2 and FOXA3 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glucocorticoid Receptor Regulatory Network&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR3C1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17075</classIRI>
<classLabel>Progesterone Receptor</classLabel>
<deletedAxiom>&apos;Progesterone Receptor&apos; EquivalentTo &apos;Steroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cellular Anthrax Toxin Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Nuclear Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PGR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Progesterone Receptor&apos; EquivalentTo &apos;Steroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cellular Anthrax Toxin Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PGR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113542</classIRI>
<classLabel>Probable G-Protein Coupled Receptor 101</classLabel>
<deletedAxiom>&apos;Probable G-Protein Coupled Receptor 101&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Adrenergic Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPR101 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Probable G-Protein Coupled Receptor 101&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Adrenergic Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPR101 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61062</classIRI>
<classLabel>Catalase</classLabel>
<deletedAxiom>&apos;Catalase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glyoxylate and Dicarboxylate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXO Transcription Factor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lumen of the Peroxisome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CAT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Catalase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glyoxylate and Dicarboxylate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXO Transcription Factor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lumen of the Peroxisome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CAT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16498</classIRI>
<classLabel>Deoxycytidine Kinase</classLabel>
<deletedAxiom>&apos;Deoxycytidine Kinase&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Ovarian Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Resistance Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Efflux&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DCK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Deoxycytidine Kinase&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Ovarian Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Resistance Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Efflux&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DCK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16473</classIRI>
<classLabel>Creatine Kinase B-Type</classLabel>
<deletedAxiom>&apos;Creatine Kinase B-Type&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Energy Metabolism Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CKB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Creatine Kinase B-Type&apos; EquivalentTo &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Energy Metabolism Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CKB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16485</classIRI>
<classLabel>Cytochrome P450 2E1</classLabel>
<deletedAxiom>&apos;Cytochrome P450 2E1&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acetaminophen Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Biomarker&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Heme Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ethanol Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carcinogen Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2E1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 2E1&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acetaminophen Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Biomarker&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Heme Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ethanol Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carcinogen Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2E1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16484</classIRI>
<classLabel>Cytochrome P450</classLabel>
<deletedAxiom>&apos;Cytochrome P450&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16574</classIRI>
<classLabel>Fatty Acid Synthase</classLabel>
<deletedAxiom>&apos;Fatty Acid Synthase&apos; EquivalentTo &apos;Acyltransferase&apos; and &apos;Esterase&apos; and &apos;Lyase&apos; and &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Elongation Pathway in Mitochondria&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Acyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FASN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fatty Acid Synthase&apos; EquivalentTo &apos;Acyltransferase&apos; and &apos;Esterase&apos; and &apos;Lyase&apos; and &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Elongation Pathway in Mitochondria&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FASN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16509</classIRI>
<classLabel>DNA Nucleotidylexotransferase</classLabel>
<deletedAxiom>&apos;DNA Nucleotidylexotransferase&apos; EquivalentTo &apos;DNA Polymerase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Polymerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Generation of Antibody Diversity&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNTT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Nucleotidylexotransferase&apos; EquivalentTo &apos;DNA Polymerase&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Generation of Antibody Diversity&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNTT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16516</classIRI>
<classLabel>Topoisomerase I</classLabel>
<deletedAxiom>&apos;Topoisomerase I&apos; EquivalentTo &apos;Topoisomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Topoisomerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Topoisomerase I&apos; EquivalentTo &apos;Topoisomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16285</classIRI>
<classLabel>Amyloid Beta A4 Protein</classLabel>
<deletedAxiom>&apos;Amyloid Beta A4 Protein&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyloid Beta-Peptide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Amyloid Precursor Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Alzheimer&apos;s Disease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;APP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Amyloid Beta A4 Protein&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyloid Beta-Peptide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Amyloid Precursor Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Alzheimer&apos;s Disease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;APP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16254</classIRI>
<classLabel>Estradiol 17-Beta-Dehydrogenase 2</classLabel>
<deletedAxiom>&apos;Estradiol 17-Beta-Dehydrogenase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Disease Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HSD17B2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Estradiol 17-Beta-Dehydrogenase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Disease Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HSD17B2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16260</classIRI>
<classLabel>Adenine Phosphoribosyltransferase</classLabel>
<deletedAxiom>&apos;Adenine Phosphoribosyltransferase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;APRT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Adenine Phosphoribosyltransferase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;APRT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16261</classIRI>
<classLabel>Adenosine Deaminase</classLabel>
<deletedAxiom>&apos;Adenosine Deaminase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Severe Combined Immunodeficiency&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Adenosine Deaminase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Severe Combined Immunodeficiency&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16263</classIRI>
<classLabel>ATPase</classLabel>
<newAxiom>&apos;ATPase&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16376</classIRI>
<classLabel>Mitogen-Activated Protein Kinase</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16387</classIRI>
<classLabel>Catechol O-Methyltransferase</classLabel>
<deletedAxiom>&apos;Catechol O-Methyltransferase&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tyrosine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Metal Binding Site&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Methylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;COMT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Catechol O-Methyltransferase&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tyrosine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Metal Binding Site&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Methylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;COMT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20939</classIRI>
<classLabel>RAC-Gamma Serine/Threonine Kinase</classLabel>
<deletedAxiom>&apos;RAC-Gamma Serine/Threonine Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nicotinate and Nicotinamide Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Starch and Sucrose Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase B&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intermediary Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AKT3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAC-Gamma Serine/Threonine Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inositol Phosphate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nicotinate and Nicotinamide Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Starch and Sucrose Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingosine 1-Phosphate Receptor 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase B&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intermediary Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AKT3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20983</classIRI>
<classLabel>Serine Hydrolase</classLabel>
<deletedAxiom>&apos;Serine Hydrolase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20969</classIRI>
<classLabel>Muscarinic Acetylcholine Receptor M5</classLabel>
<deletedAxiom>&apos;Muscarinic Acetylcholine Receptor M5&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRM5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Muscarinic Acetylcholine Receptor M5&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRM5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20961</classIRI>
<classLabel>M-Phase Inducer Phosphatase 1</classLabel>
<deletedAxiom>&apos;M-Phase Inducer Phosphatase 1&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDC25A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;M-Phase Inducer Phosphatase 1&apos; EquivalentTo &apos;Protein Tyrosine Phosphatase&apos; and &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDC25A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20967</classIRI>
<classLabel>Muscarinic Acetylcholine Receptor M3</classLabel>
<deletedAxiom>&apos;Muscarinic Acetylcholine Receptor M3&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRM3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Muscarinic Acetylcholine Receptor M3&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRM3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20965</classIRI>
<classLabel>Muscarinic Acetylcholine Receptor M1</classLabel>
<deletedAxiom>&apos;Muscarinic Acetylcholine Receptor M1&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Botulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tubby Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRM1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Muscarinic Acetylcholine Receptor M1&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Botulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tubby Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRM1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20959</classIRI>
<classLabel>G1/S-Specific Cyclin-E2</classLabel>
<deletedAxiom>&apos;G1/S-Specific Cyclin-E2&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Phosphoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNE2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G1/S-Specific Cyclin-E2&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Phosphoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNE2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20955</classIRI>
<classLabel>Bombesin Receptor Subtype-3</classLabel>
<deletedAxiom>&apos;Bombesin Receptor Subtype-3&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BRS3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Bombesin Receptor Subtype-3&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BRS3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20956</classIRI>
<classLabel>Cyclin-A2</classLabel>
<deletedAxiom>&apos;Cyclin-A2&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hepatocellular Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNA2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-A2&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hepatocellular Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNA2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16890</classIRI>
<classLabel>NADPH-Cytochrome P450 Reductase</classLabel>
<deletedAxiom>&apos;NADPH-Cytochrome P450 Reductase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Aromatase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Estrogen Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;POR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NADPH-Cytochrome P450 Reductase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Aromatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Estrogen Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;POR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20465</classIRI>
<classLabel>Thioredoxin</classLabel>
<deletedAxiom>&apos;Thioredoxin&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon Signaling Modulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Adult T-Cell Leukemia/Lymphoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TXN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Thioredoxin&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon Signaling Modulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Adult T-Cell Leukemia/Lymphoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TXN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20415</classIRI>
<classLabel>Bcl-X(S)</classLabel>
<deletedAxiom>&apos;Bcl-X(S)&apos; EquivalentTo &apos;Apoptosis Regulator&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Outer Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;BH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Promoter&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCL2L1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Bcl-X(S)&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125668 and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Outer Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;BH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Promoter&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCL2L1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16802</classIRI>
<classLabel>Luciferase</classLabel>
<deletedAxiom>&apos;Luciferase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Lampyridae&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;)</deletedAxiom>
<newAxiom>&apos;Luciferase&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;</newAxiom>
<newAxiom>&apos;Luciferase&apos; SubClassOf &apos;Gene_Product_Has_Organism_Source&apos; some &apos;Lampyridae&apos;</newAxiom>
<newAxiom>&apos;Luciferase&apos; SubClassOf &apos;Oxidoreductase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20367</classIRI>
<classLabel>MCM Protein</classLabel>
<deletedAxiom>&apos;MCM Protein&apos; SubClassOf &apos;Licensing Factor&apos;</deletedAxiom>
<newAxiom>&apos;MCM Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Maintenance Process&apos;</newAxiom>
<newAxiom>&apos;MCM Protein&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;</newAxiom>
<newAxiom>&apos;MCM Protein&apos; SubClassOf &apos;Protein Family&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16860</classIRI>
<classLabel>Epoxide Hydrolase 1</classLabel>
<deletedAxiom>&apos;Epoxide Hydrolase 1&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Malignant Breast Neoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EPHX1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Epoxide Hydrolase 1&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Malignant Breast Neoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EPHX1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16836</classIRI>
<classLabel>Neprilysin</classLabel>
<deletedAxiom>&apos;Neprilysin&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renin-Angiotensin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Differentiation Antigen&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Aging&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Peptide Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MME Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Neprilysin&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renin-Angiotensin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Differentiation Antigen&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Aging&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Peptide Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MME Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16843</classIRI>
<classLabel>Metalloproteinase</classLabel>
<deletedAxiom>&apos;Metalloproteinase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16849</classIRI>
<classLabel>Methyltransferase</classLabel>
<deletedAxiom>&apos;Methyltransferase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16819</classIRI>
<classLabel>Superoxide Dismutase [Mn], Mitochondrial</classLabel>
<deletedAxiom>&apos;Superoxide Dismutase [Mn], Mitochondrial&apos; EquivalentTo &apos;Superoxide Dismutase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Neuroprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Longevity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrial Matrix&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SOD2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Superoxide Dismutase [Mn], Mitochondrial&apos; EquivalentTo &apos;Superoxide Dismutase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Neuroprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Longevity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrial Matrix&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SOD2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20318</classIRI>
<classLabel>ATP-Dependent DNA Helicase Q4</classLabel>
<deletedAxiom>&apos;ATP-Dependent DNA Helicase Q4&apos; EquivalentTo &apos;RecQ Helicase Family Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Helicase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RECQL4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;ATP-Dependent DNA Helicase Q4&apos; EquivalentTo &apos;RecQ Helicase Family Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RECQL4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20319</classIRI>
<classLabel>Licensing Factor</classLabel>
<deletedAxiom>&apos;Licensing Factor&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;</deletedAxiom>
<newAxiom>&apos;Licensing Factor&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20316</classIRI>
<classLabel>Werner Syndrome ATP-Dependent Helicase</classLabel>
<deletedAxiom>&apos;Werner Syndrome ATP-Dependent Helicase&apos; EquivalentTo &apos;RecQ Helicase Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Werner Syndrome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Helicase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Binding Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;3&apos;-5&apos; Exonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Double Strand Break Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Base Excision Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WRN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Werner Syndrome ATP-Dependent Helicase&apos; EquivalentTo &apos;RecQ Helicase Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Werner Syndrome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Binding Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;3&apos;-5&apos; Exonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Double Strand Break Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Base Excision Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;WRN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16984</classIRI>
<classLabel>Phosphotransferase</classLabel>
<newAxiom>&apos;Phosphotransferase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Kinase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16995</classIRI>
<classLabel>Tissue-Type Plasminogen Activator</classLabel>
<deletedAxiom>&apos;Tissue-Type Plasminogen Activator&apos; EquivalentTo &apos;Plasminogen Activator&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myocardial Infarction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fibrinolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Amyloid Precursor Protein Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Kringle Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Plasminogen Activator&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLAT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tissue-Type Plasminogen Activator&apos; EquivalentTo &apos;Plasminogen Activator&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myocardial Infarction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fibrinolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Amyloid Precursor Protein Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Kringle Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLAT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16965</classIRI>
<classLabel>Peptidase</classLabel>
<deletedAxiom>&apos;Peptidase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20636</classIRI>
<classLabel>Polymerase</classLabel>
<deletedAxiom>&apos;Polymerase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106640</classIRI>
<classLabel>Cyclic GMP-AMP Synthase</classLabel>
<deletedAxiom>&apos;Cyclic GMP-AMP Synthase&apos; EquivalentTo &apos;Nucleotidyltransferase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunity&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MB21D1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclic GMP-AMP Synthase&apos; EquivalentTo &apos;Nucleotidyltransferase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunity&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MB21D1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20596</classIRI>
<classLabel>ATP-Dependent DNA Helicase Q5</classLabel>
<deletedAxiom>&apos;ATP-Dependent DNA Helicase Q5&apos; EquivalentTo &apos;RecQ Helicase Family Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Helicase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RECQL5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;ATP-Dependent DNA Helicase Q5&apos; EquivalentTo &apos;RecQ Helicase Family Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RECQL5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16640</classIRI>
<classLabel>Glucose-6-Phosphate 1-Dehydrogenase</classLabel>
<deletedAxiom>&apos;Glucose-6-Phosphate 1-Dehydrogenase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glutathione Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pentose Phosphate Cycle Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Anemia&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Jaundice&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;G6PD Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Glucose-6-Phosphate 1-Dehydrogenase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glutathione Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pentose Phosphate Cycle Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Anemia&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Jaundice&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;G6PD Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16796</classIRI>
<classLabel>Ligase</classLabel>
<deletedAxiom>&apos;Ligase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Enzyme&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16752</classIRI>
<classLabel>Thyroid Peroxidase</classLabel>
<deletedAxiom>&apos;Thyroid Peroxidase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tyrosine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Autoimmune Thyroid Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Graves Disease&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hyperthyroidism&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Sushi Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TPO Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Thyroid Peroxidase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tyrosine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Autoimmune Thyroid Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Graves Disease&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hyperthyroidism&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Sushi Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TPO Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102485</classIRI>
<classLabel>Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A</classLabel>
<deletedAxiom>&apos;Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;FK506 Binding Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Isomerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FKBP1A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A&apos; EquivalentTo &apos;Isomerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;FK506 Binding Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FKBP1A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102479</classIRI>
<classLabel>Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase C</classLabel>
<deletedAxiom>&apos;Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase C&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Glycan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Glycosylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MGAT4C Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase C&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Glycan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Glycosylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MGAT4C Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102491</classIRI>
<classLabel>Histone Deacetylase 7</classLabel>
<deletedAxiom>&apos;Histone Deacetylase 7&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Deacetylase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Deacetylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Migration Induction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Angiogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Deacetylase 7&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Deacetylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Migration Induction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Angiogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102494</classIRI>
<classLabel>Histone Deacetylase 9</classLabel>
<deletedAxiom>&apos;Histone Deacetylase 9&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Signal Dependent Regulation of Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Deacetylase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Differentiation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Deacetylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Migration Induction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Angiogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Deacetylase 9&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Signal Dependent Regulation of Myogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Differentiation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Deacetylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Migration Induction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Angiogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102442</classIRI>
<classLabel>Chromodomain-Helicase-DNA-Binding Protein 8</classLabel>
<deletedAxiom>&apos;Chromodomain-Helicase-DNA-Binding Protein 8&apos; EquivalentTo &apos;DNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Helicase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHD8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Chromodomain-Helicase-DNA-Binding Protein 8&apos; EquivalentTo &apos;DNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHD8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73690</classIRI>
<classLabel>DNA (Cytosine-5)-Methyltransferase 1</classLabel>
<deletedAxiom>&apos;DNA (Cytosine-5)-Methyltransferase 1&apos; EquivalentTo &apos;DNA Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNMT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA (Cytosine-5)-Methyltransferase 1&apos; EquivalentTo &apos;DNA Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNMT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102506</classIRI>
<classLabel>Glutaminyl-Peptide Cyclotransferase</classLabel>
<deletedAxiom>&apos;Glutaminyl-Peptide Cyclotransferase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Acyltransferase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73691</classIRI>
<classLabel>DNA (Cytosine-5)-Methyltransferase 3A</classLabel>
<deletedAxiom>&apos;DNA (Cytosine-5)-Methyltransferase 3A&apos; EquivalentTo &apos;DNA Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNMT3A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA (Cytosine-5)-Methyltransferase 3A&apos; EquivalentTo &apos;DNA Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNMT3A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102530</classIRI>
<classLabel>Angiotensin-Converting Enzyme 2</classLabel>
<deletedAxiom>&apos;Angiotensin-Converting Enzyme 2&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin-converting Enzyme 2 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renin-Angiotensin Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACE2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Angiotensin-Converting Enzyme 2&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin-converting Enzyme 2 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renin-Angiotensin Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACE2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118965</classIRI>
<classLabel>Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6</classLabel>
<deletedAxiom>&apos;Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Trans-Golgi Network&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LGR6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Trans-Golgi Network&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LGR6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20132</classIRI>
<classLabel>Phosphoprotein Phosphatase</classLabel>
<deletedAxiom>&apos;Phosphoprotein Phosphatase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20145</classIRI>
<classLabel>Caspase-2</classLabel>
<deletedAxiom>&apos;Caspase-2&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Stress Related Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Fetus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Caspase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Caspase-2&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Stress Related Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Fetus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20183</classIRI>
<classLabel>Telomere Reverse Transcriptase</classLabel>
<deletedAxiom>&apos;Telomere Reverse Transcriptase&apos; EquivalentTo &apos;Reverse Transcriptase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Telomerase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Polymerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Telomere Maintenance&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TERT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Telomere Reverse Transcriptase&apos; EquivalentTo &apos;Reverse Transcriptase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Telomerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Telomere Maintenance&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TERT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28642</classIRI>
<classLabel>DNA Replication Licensing Factor MCM2</classLabel>
<deletedAxiom>&apos;DNA Replication Licensing Factor MCM2&apos; EquivalentTo &apos;MCM Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Replication Factor Cdt1&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Replication Licensing Factor MCM2&apos; EquivalentTo &apos;Licensing Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;MCM Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Licensing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28684</classIRI>
<classLabel>DNA Replication Licensing Factor MCM3</classLabel>
<deletedAxiom>&apos;DNA Replication Licensing Factor MCM3&apos; EquivalentTo &apos;MCM Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Pre-Replication Complex&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Replication Factor Cdt1&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Replication Licensing Factor MCM3&apos; EquivalentTo &apos;Licensing Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Pre-Replication Complex&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;MCM Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MCM3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28678</classIRI>
<classLabel>Cell Division Cycle 7-Related Protein Kinase</classLabel>
<deletedAxiom>&apos;Cell Division Cycle 7-Related Protein Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Protein Deregulation&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;CDC7L1 Kinase Complex&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDC7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cell Division Cycle 7-Related Protein Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Protein Deregulation&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;CDC7L1 Kinase Complex&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDC7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28673</classIRI>
<classLabel>CDC45-Related Protein</classLabel>
<deletedAxiom>&apos;CDC45-Related Protein&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDC45L Gene&apos;)</deletedAxiom>
<newAxiom>&apos;CDC45-Related Protein&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Replication Initiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDC45L Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28671</classIRI>
<classLabel>Protein DBF4 homolog A</classLabel>
<deletedAxiom>&apos;Protein DBF4 homolog A&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;CDC7L1 Kinase Complex&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DBF4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein DBF4 homolog A&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;CDC7L1 Kinase Complex&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DBF4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28714</classIRI>
<classLabel>Activin Receptor Type-1B</classLabel>
<deletedAxiom>&apos;Activin Receptor Type-1B&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Cytoplasmic Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Extracellular Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVR1B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Activin Receptor Type-1B&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Cytoplasmic Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Extracellular Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVR1B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20109</classIRI>
<classLabel>DNA Topoisomerase 3-Alpha</classLabel>
<deletedAxiom>&apos;DNA Topoisomerase 3-Alpha&apos; EquivalentTo &apos;Topoisomerase III&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Homologous Recombination Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Topoisomerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOP3A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Topoisomerase 3-Alpha&apos; EquivalentTo &apos;Topoisomerase III&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Homologous Recombination Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOP3A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28750</classIRI>
<classLabel>Cytochrome P450 2C9</classLabel>
<deletedAxiom>&apos;Cytochrome P450 2C9&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2C9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 2C9&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2C9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102903</classIRI>
<classLabel>Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Serine/Threonine Phosphatase&apos;</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Complex Subunit&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102911</classIRI>
<classLabel>Serine/Threonine-Protein Kinase 19</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase 19&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102917</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase BRE1A</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase BRE1A&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Monoubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Migration Inhibition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNF20 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase BRE1A&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Monoubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Migration Inhibition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNF20 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28434</classIRI>
<classLabel>Caspase-5</classLabel>
<deletedAxiom>&apos;Caspase-5&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;T Acute Lymphoblastic Leukemia&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Caspase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Caspase-5&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;T Acute Lymphoblastic Leukemia&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102923</classIRI>
<classLabel>Collagenase 3</classLabel>
<deletedAxiom>&apos;Collagenase 3&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Matrix Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Extracellular Matrix Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP13 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Collagenase 3&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Collagenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Extracellular Matrix Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP13 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28439</classIRI>
<classLabel>Caspase-7</classLabel>
<deletedAxiom>&apos;Caspase-7&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptotic DNA Fragmentation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitochondria in Apoptotic Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Caspase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Caspase-7&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptotic DNA Fragmentation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitochondria in Apoptotic Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28431</classIRI>
<classLabel>Caspase-4</classLabel>
<deletedAxiom>&apos;Caspase-4&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Caspase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Caspase-4&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102932</classIRI>
<classLabel>DnaJ Homolog Subfamily B Member 6</classLabel>
<deletedAxiom>&apos;DnaJ Homolog Subfamily B Member 6&apos; EquivalentTo &apos;Chaperone&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;DNAJ Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Sarcomere&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chaperone&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chaperone Protein Interaction Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNAJB6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DnaJ Homolog Subfamily B Member 6&apos; EquivalentTo &apos;Chaperone&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;DNAJ Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Sarcomere&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chaperone Protein Interaction Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNAJB6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102938</classIRI>
<classLabel>Synphilin-1</classLabel>
<deletedAxiom>&apos;Synphilin-1&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-Proteasomal Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SNCAIP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Synphilin-1&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-Proteasomal Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SNCAIP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102935</classIRI>
<classLabel>Lysocardiolipin Acyltransferase 1</classLabel>
<deletedAxiom>&apos;Lysocardiolipin Acyltransferase 1&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerophospholipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Acyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LCLAT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Lysocardiolipin Acyltransferase 1&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerophospholipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LCLAT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28427</classIRI>
<classLabel>Caspase-9</classLabel>
<deletedAxiom>&apos;Caspase-9&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D4-GDI Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HSP27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitochondria in Apoptotic Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;West Nile Virus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Caspase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Caspase-9&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D4-GDI Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HSP27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitochondria in Apoptotic Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;West Nile Virus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28492</classIRI>
<classLabel>Tyrosine-Protein Kinase JAK3</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase JAK3&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL22 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stat3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Natural Killer Cell&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;JAK3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase JAK3&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL22 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stat3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Natural Killer Cell&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;JAK3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28493</classIRI>
<classLabel>Tyrosine-Protein Kinase JAK1</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase JAK1&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN Alpha Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL10 Anti-inflammatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL22 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stat3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;JAK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase JAK1&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN Alpha Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL10 Anti-inflammatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL22 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stat3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;JAK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28494</classIRI>
<classLabel>Tyrosine-Protein Kinase JAK2</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase JAK2&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Neuroprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL22 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NO2-Dependent IL12 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon Signaling Modulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Polycythemia Vera&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hodgkin Lymphoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;JAK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase JAK2&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Neuroprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IFN Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL22 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NO2-Dependent IL12 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon Signaling Modulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Polycythemia Vera&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hodgkin Lymphoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;JAK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102958</classIRI>
<classLabel>Homeodomain-Interacting Protein Kinase 2</classLabel>
<deletedAxiom>&apos;Homeodomain-Interacting Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HIPK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Homeodomain-Interacting Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Pathway for Transcriptional Regulation&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HIPK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28482</classIRI>
<classLabel>Coagulation Factor IX</classLabel>
<deletedAxiom>&apos;Coagulation Factor IX&apos; SubClassOf &apos;Serine Protease&apos;</deletedAxiom>
<deletedAxiom>&apos;Coagulation Factor IX&apos; EquivalentTo &apos;Coagulation Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Amyloid Precursor Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hemophilia B&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;F9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Coagulation Factor IX&apos; EquivalentTo &apos;Coagulation Factor&apos; and &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Amyloid Precursor Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hemophilia B&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Coagulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;F9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28485</classIRI>
<classLabel>Kallikrein-15</classLabel>
<deletedAxiom>&apos;Kallikrein-15&apos; EquivalentTo &apos;Kallikrein&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Factor&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thyroid Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Salivary Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Adrenal Gland&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Kallikrein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KLK15 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Kallikrein-15&apos; EquivalentTo &apos;Kallikrein&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Factor&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thyroid Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Salivary Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Adrenal Gland&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KLK15 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28558</classIRI>
<classLabel>High Affinity Nerve Growth Factor Receptor</classLabel>
<deletedAxiom>&apos;High Affinity Nerve Growth Factor Receptor&apos; EquivalentTo &apos;NTRK1 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Branching Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Trka Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Thyroid Gland Medullary Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nociception&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NTRK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;High Affinity Nerve Growth Factor Receptor&apos; EquivalentTo &apos;NTRK1 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Branching Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Trka Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Thyroid Gland Medullary Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nociception&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NTRK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28511</classIRI>
<classLabel>Nitric Oxide Synthetase</classLabel>
<deletedAxiom>&apos;Nitric Oxide Synthetase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28526</classIRI>
<classLabel>Macrophage-Stimulating Protein Receptor</classLabel>
<deletedAxiom>&apos;Macrophage-Stimulating Protein Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Stimulating 1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MST1R Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Macrophage-Stimulating Protein Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Stimulating 1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MST1R Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28528</classIRI>
<classLabel>Muscle, Skeletal Receptor Tyrosine-Protein Kinase</classLabel>
<deletedAxiom>&apos;Muscle, Skeletal Receptor Tyrosine-Protein Kinase&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Postsynaptic Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Frizzled Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MUSK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Muscle, Skeletal Receptor Tyrosine-Protein Kinase&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Postsynaptic Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Frizzled Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MUSK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102772</classIRI>
<classLabel>NAD-Dependent Protein Deacetylase Sirtuin-7</classLabel>
<deletedAxiom>&apos;NAD-Dependent Protein Deacetylase Sirtuin-7&apos; EquivalentTo &apos;Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class III Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Deacetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deacetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SIRT7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NAD-Dependent Protein Deacetylase Sirtuin-7&apos; EquivalentTo &apos;Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class III Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deacetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SIRT7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102762</classIRI>
<classLabel>SRSF Protein Kinase 1</classLabel>
<deletedAxiom>&apos;SRSF Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Matrix Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nuclear Matrix&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Splicing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Condensation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Segregation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SRPK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SRSF Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Matrix Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nuclear Matrix&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Splicing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Condensation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Segregation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SRPK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102778</classIRI>
<classLabel>Acyl-CoA Desaturase</classLabel>
<deletedAxiom>&apos;Acyl-CoA Desaturase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Biosynthesis of Unsaturated Fatty Acids Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SCD Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Acyl-CoA Desaturase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Biosynthesis of Unsaturated Fatty Acids Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SCD Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102775</classIRI>
<classLabel>S-Adenosylmethionine Decarboxylase Proenzyme</classLabel>
<deletedAxiom>&apos;S-Adenosylmethionine Decarboxylase Proenzyme&apos; EquivalentTo &apos;Lyase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Lyase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biogenic Amine Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AMD1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;S-Adenosylmethionine Decarboxylase Proenzyme&apos; EquivalentTo &apos;Lyase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biogenic Amine Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AMD1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28288</classIRI>
<classLabel>UDP-Glucuronosyltransferase 1-1</classLabel>
<deletedAxiom>&apos;UDP-Glucuronosyltransferase 1-1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ascorbate and Aldarate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pentose and Glucuronate Interconversions Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Porphyrin and Chlorophyll Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Starch and Sucrose Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Estrogen Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UGT1A1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;UDP-Glucuronosyltransferase 1-1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ascorbate and Aldarate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pentose and Glucuronate Interconversions Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Porphyrin and Chlorophyll Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Starch and Sucrose Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Estrogen Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UGT1A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102801</classIRI>
<classLabel>Reelin</classLabel>
<deletedAxiom>&apos;Reelin&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LIS1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ECM-Receptor Interaction Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lissencephaly-1 Gene in Neuronal Migration and Development&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Matrix&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Cerebellum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nervous System Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RELN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Reelin&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LIS1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ECM-Receptor Interaction Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lissencephaly-1 Gene in Neuronal Migration and Development&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Matrix&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Cerebellum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nervous System Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RELN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102810</classIRI>
<classLabel>6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3</classLabel>
<deletedAxiom>&apos;6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3&apos; EquivalentTo &apos;Esterase&apos; and &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fructose and Mannose Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphotransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Glycolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PFKFB3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3&apos; EquivalentTo &apos;Phosphatase&apos; and &apos;Phosphotransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fructose and Mannose Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Glycolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PFKFB3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102826</classIRI>
<classLabel>Vitamin K-Dependent Protein C</classLabel>
<deletedAxiom>&apos;Vitamin K-Dependent Protein C&apos; EquivalentTo &apos;Coagulation Factor&apos; and &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myocardial Infarction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Segmentation Clock Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Plasma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Coagulation Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Coagulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Leukocyte Trafficking&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Turnover&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PROC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Vitamin K-Dependent Protein C&apos; EquivalentTo &apos;Coagulation Factor&apos; and &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myocardial Infarction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Segmentation Clock Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Plasma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Coagulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Leukocyte Trafficking&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Turnover&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PROC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102829</classIRI>
<classLabel>Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3</classLabel>
<deletedAxiom>&apos;Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF2 Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EIF2AK3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF2 Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EIF2AK3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102890</classIRI>
<classLabel>CTD Nuclear Envelope Phosphatase 1</classLabel>
<deletedAxiom>&apos;CTD Nuclear Envelope Phosphatase 1&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nuclear Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Serine/Threonine Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CTDNEP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;CTD Nuclear Envelope Phosphatase 1&apos; EquivalentTo &apos;Protein Serine/Threonine Phosphatase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nuclear Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CTDNEP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C124088</classIRI>
<classLabel>Metalloproteinase Inhibitor 4</classLabel>
<deletedAxiom>&apos;Metalloproteinase Inhibitor 4&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Tissue Inhibitor of Metalloproteinases&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C124075</classIRI>
<classLabel>Fibroblast Growth Factor Receptor 2 Isoform IIIb</classLabel>
<deletedAxiom>&apos;Fibroblast Growth Factor Receptor 2 Isoform IIIb&apos; EquivalentTo &apos;FGFR2 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Keratinocyte&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Epithelial Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGFR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fibroblast Growth Factor Receptor 2 Isoform IIIb&apos; EquivalentTo &apos;FGFR2 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Keratinocyte&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Epithelial Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGFR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C119633</classIRI>
<classLabel>Ras-Related Protein Rab-7a</classLabel>
<deletedAxiom>&apos;Ras-Related Protein Rab-7a&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Membrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lysosome&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Late Endosome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Small G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Degradation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Transport&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAB7A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ras-Related Protein Rab-7a&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Membrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lysosome&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Late Endosome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Degradation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Transport&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAB7A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C119603</classIRI>
<classLabel>Serine/Threonine-Protein Kinase PLK4</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase PLK4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK2 and PLK4 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centriole&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Polo-Box Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G2 to M Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLK4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase PLK4&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK2 and PLK4 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centriole&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Polo-Box Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G2 to M Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLK4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74519</classIRI>
<classLabel>Regulator of G-Protein Signaling 5</classLabel>
<deletedAxiom>&apos;Regulator of G-Protein Signaling 5&apos; EquivalentTo &apos;RGS Family Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 5&apos; SubClassOf &apos;RGS Family Protein&apos;</newAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 5&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
<newAxiom>&apos;Regulator of G-Protein Signaling 5&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS5 Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18072</classIRI>
<classLabel>Enzyme Inhibitor Protein</classLabel>
<deletedAxiom>&apos;Enzyme Inhibitor Protein&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18045</classIRI>
<classLabel>Caspase-1</classLabel>
<deletedAxiom>&apos;Caspase-1&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D4-GDI Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL18 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytosolic DNA-Sensing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cellular Anthrax Toxin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Caspase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Caspase-1&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D4-GDI Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL18 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytosolic DNA-Sensing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cellular Anthrax Toxin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18050</classIRI>
<classLabel>Exostosin-1</classLabel>
<deletedAxiom>&apos;Exostosin-1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Golgi Apparatus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hereditary Multiple Exostoses&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Heparan Sulfate Biosynthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Limb Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EXT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Exostosin-1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Golgi Apparatus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hereditary Multiple Exostoses&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Heparan Sulfate Biosynthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Limb Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EXT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18030</classIRI>
<classLabel>Tyrosine-Protein Phosphatase Non-Receptor Type 11</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 11&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Co-Stimulatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metabolic Control&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN11 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Phosphatase Non-Receptor Type 11&apos; EquivalentTo &apos;Non-Receptor Type Protein Tyrosine Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Co-Stimulatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PTB Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcription&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metabolic Control&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTPN11 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18031</classIRI>
<classLabel>Caspase-3</classLabel>
<deletedAxiom>&apos;Caspase-3&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D4-GDI Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptotic DNA Fragmentation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HSP27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitochondria in Apoptotic Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Granzyme A Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TSP-1 Induced Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;West Nile Virus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Alzheimer&apos;s Disease&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Caspase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Caspase-3&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D4-GDI Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptotic DNA Fragmentation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HSP27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitochondria in Apoptotic Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Granzyme A Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TSP-1 Induced Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;West Nile Virus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Alzheimer&apos;s Disease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18037</classIRI>
<classLabel>Exostosin-2</classLabel>
<deletedAxiom>&apos;Exostosin-2&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Golgi Apparatus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hereditary Multiple Exostoses&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Heparan Sulfate Biosynthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Limb Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EXT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Exostosin-2&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycosaminoglycan Biosynthesis Pathway - Heparan Sulfate&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Golgi Apparatus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hereditary Multiple Exostoses&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Heparan Sulfate Biosynthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Limb Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EXT2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97462</classIRI>
<classLabel>Probable ATP-Dependent RNA Helicase DDX5</classLabel>
<deletedAxiom>&apos;Probable ATP-Dependent RNA Helicase DDX5&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Spliceosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Helicase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Splicing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDX5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Probable ATP-Dependent RNA Helicase DDX5&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Spliceosome Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Splicing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDX5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97459</classIRI>
<classLabel>Probable ATP-Dependent RNA Helicase DDX10</classLabel>
<deletedAxiom>&apos;Probable ATP-Dependent RNA Helicase DDX10&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Helicase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97451</classIRI>
<classLabel>Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1</classLabel>
<deletedAxiom>&apos;Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF2 Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Translation Process Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EIF2AK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF2 Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Translation Process Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translational Repression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EIF2AK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97444</classIRI>
<classLabel>N-Chimaerin</classLabel>
<deletedAxiom>&apos;N-Chimaerin&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase-Activating Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHN1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;N-Chimaerin&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHN1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18106</classIRI>
<classLabel>Receptor</classLabel>
<deletedAxiom>&apos;Receptor&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97597</classIRI>
<classLabel>Lysine-Specific Demethylase 5A</classLabel>
<deletedAxiom>&apos;Lysine-Specific Demethylase 5A&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ARID Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KDM5A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Lysine-Specific Demethylase 5A&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ARID Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KDM5A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18015</classIRI>
<classLabel>Prostatic Acid Phosphatase</classLabel>
<deletedAxiom>&apos;Prostatic Acid Phosphatase&apos; EquivalentTo &apos;Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Riboflavin Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACPP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Prostatic Acid Phosphatase&apos; EquivalentTo &apos;Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Riboflavin Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACPP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97564</classIRI>
<classLabel>Growth Arrest-Specific Protein 7</classLabel>
<deletedAxiom>&apos;Growth Arrest-Specific Protein 7&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18026</classIRI>
<classLabel>Tyrosine-Protein Kinase Fer</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Fer&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FER Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Fer&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mast/Stem Cell Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FER Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18025</classIRI>
<classLabel>Bis(5&apos;-Adenosyl)-Triphosphatase</classLabel>
<deletedAxiom>&apos;Bis(5&apos;-Adenosyl)-Triphosphatase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FHIT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Bis(5&apos;-Adenosyl)-Triphosphatase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FHIT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18023</classIRI>
<classLabel>DNA Polymerase Beta</classLabel>
<deletedAxiom>&apos;DNA Polymerase Beta&apos; EquivalentTo &apos;DNA-directed DNA Polymerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Base Excision Repair Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Polymerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Resistance Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Maintenance&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Base Excision Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;POLB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Polymerase Beta&apos; EquivalentTo &apos;DNA-directed DNA Polymerase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Base Excision Repair Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Resistance Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Maintenance&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Base Excision Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;POLB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97508</classIRI>
<classLabel>Rho GTPase-Activating Protein 26</classLabel>
<deletedAxiom>&apos;Rho GTPase-Activating Protein 26&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Focal Adhesion&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase-Activating Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ARHGAP26 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Rho GTPase-Activating Protein 26&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Focal Adhesion&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ARHGAP26 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97527</classIRI>
<classLabel>Gephyrin</classLabel>
<deletedAxiom>&apos;Gephyrin&apos; EquivalentTo &apos;Transferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GABA Receptor Life Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Nucleotidyltransferase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPHN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Gephyrin&apos; EquivalentTo &apos;Transferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GABA Receptor Life Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Nucleotidyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GPHN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97521</classIRI>
<classLabel>Long-Chain-Fatty-Acid-CoA Ligase 6</classLabel>
<deletedAxiom>&apos;Long-Chain-Fatty-Acid-CoA Ligase 6&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Peroxisome&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACSL6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Long-Chain-Fatty-Acid-CoA Ligase 6&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Peroxisome&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACSL6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97524</classIRI>
<classLabel>GMP Synthase [Glutamine-Hydrolyzing]</classLabel>
<deletedAxiom>&apos;GMP Synthase [Glutamine-Hydrolyzing]&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Biosynthesis Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GMPS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;GMP Synthase [Glutamine-Hydrolyzing]&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Biosynthesis Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GMPS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18294</classIRI>
<classLabel>Histone Deacetylase 2</classLabel>
<deletedAxiom>&apos;Histone Deacetylase 2&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Silencing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Deacetylase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Deacetylase 2&apos; EquivalentTo &apos;Histone Deacetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Silencing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HDAC2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18295</classIRI>
<classLabel>Suppressor of Tumorigenicity 14 Protein</classLabel>
<deletedAxiom>&apos;Suppressor of Tumorigenicity 14 Protein&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Small Intestine&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Stomach&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Leukocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ST14 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Suppressor of Tumorigenicity 14 Protein&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Small Intestine&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Stomach&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Leukocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ST14 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18291</classIRI>
<classLabel>Ras-Related Protein Ral-A</classLabel>
<deletedAxiom>&apos;Ras-Related Protein Ral-A&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RALA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ras-Related Protein Ral-A&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RALA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18293</classIRI>
<classLabel>Ras-Related Protein Ral-B</classLabel>
<deletedAxiom>&apos;Ras-Related Protein Ral-B&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RALB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ras-Related Protein Ral-B&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RALB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18287</classIRI>
<classLabel>Caspase-10</classLabel>
<deletedAxiom>&apos;Caspase-10&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D4-GDI Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TRAIL Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Non-Hodgkin Lymphoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Caspase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP10 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Caspase-10&apos; EquivalentTo &apos;Caspase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D4-GDI Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TRAIL Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Non-Hodgkin Lymphoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASP10 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18277</classIRI>
<classLabel>Small G Protein</classLabel>
<newAxiom>&apos;Small G Protein&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97292</classIRI>
<classLabel>Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase Subunit 1</classLabel>
<deletedAxiom>&apos;Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase Subunit 1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Glycan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Glycosylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RPN1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase Subunit 1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Glycan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Protein Complex Subunit&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Glycosylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RPN1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97281</classIRI>
<classLabel>Rho GTPase-Activating Protein 5</classLabel>
<deletedAxiom>&apos;Rho GTPase-Activating Protein 5&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D4-GDI Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rho Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase-Activating Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ARHGAP5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Rho GTPase-Activating Protein 5&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D4-GDI Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rho Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ARHGAP5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97262</classIRI>
<classLabel>Tissue Factor Pathway Inhibitor</classLabel>
<deletedAxiom>&apos;Tissue Factor Pathway Inhibitor&apos; EquivalentTo &apos;Serine Proteinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myocardial Infarction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Blood&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Proteinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Coagulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Enzyme Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TFPI Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tissue Factor Pathway Inhibitor&apos; EquivalentTo &apos;Serine Proteinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myocardial Infarction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extrinsic Prothrombin Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Blood&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Coagulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Enzyme Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TFPI Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97211</classIRI>
<classLabel>Complement Factor H</classLabel>
<deletedAxiom>&apos;Complement Factor H&apos; EquivalentTo &apos;Complement Component Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Sushi Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Complement Component Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Complement Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CFH Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Complement Factor H&apos; EquivalentTo &apos;Complement Component Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement and Coagulation Cascade&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Sushi Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Complement Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CFH Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97219</classIRI>
<classLabel>Aldehyde Dehydrogenase X, Mitochondrial</classLabel>
<deletedAxiom>&apos;Aldehyde Dehydrogenase X, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ascorbate and Aldarate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Alanine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycolysis/Gluconeogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Histidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysine Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pentose and Glucuronate Interconversions Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Propanoate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyruvate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Valine, Leucine and Isoleucine Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Limonene and Pinene Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrial Matrix&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Aldehyde Dehydrogenase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ethanol Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALDH1B1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Aldehyde Dehydrogenase X, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ascorbate and Aldarate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Alanine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycerolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycolysis/Gluconeogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Histidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysine Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pentose and Glucuronate Interconversions Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Propanoate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyruvate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Valine, Leucine and Isoleucine Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Limonene and Pinene Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrial Matrix&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Aldehyde Dehydrogenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ethanol Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALDH1B1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97216</classIRI>
<classLabel>PIN2/TERF1-Interacting Telomerase Inhibitor 1</classLabel>
<deletedAxiom>&apos;PIN2/TERF1-Interacting Telomerase Inhibitor 1&apos; EquivalentTo &apos;Enzyme Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centromere&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Enzyme Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metaphase Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Telomere Maintenance&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Segregation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Enzyme Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PINX1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;PIN2/TERF1-Interacting Telomerase Inhibitor 1&apos; EquivalentTo &apos;Enzyme Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centromere&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metaphase Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Telomere Maintenance&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Segregation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Enzyme Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PINX1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97208</classIRI>
<classLabel>Kallikrein-10</classLabel>
<deletedAxiom>&apos;Kallikrein-10&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;</deletedAxiom>
<deletedAxiom>&apos;Kallikrein-10&apos; SubClassOf &apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Kallikrein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18166</classIRI>
<classLabel>RGS Family Protein</classLabel>
<deletedAxiom>&apos;RGS Family Protein&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS Family Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RGS Family Protein&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RGS Family Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18168</classIRI>
<classLabel>DNA-Binding Protein Inhibitor ID-2</classLabel>
<deletedAxiom>&apos;DNA-Binding Protein Inhibitor ID-2&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;BHLH Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;bHLH Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Repressor/Corepressor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ID2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA-Binding Protein Inhibitor ID-2&apos; EquivalentTo &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;BHLH Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;bHLH Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Repressor/Corepressor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ID2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18169</classIRI>
<classLabel>Tyrosine-Protein Kinase SYK</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase SYK&apos; EquivalentTo &apos;syk Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Atypical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SYK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase SYK&apos; EquivalentTo &apos;syk Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Atypical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SYK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18153</classIRI>
<classLabel>Caspase</classLabel>
<deletedAxiom>&apos;Caspase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18152</classIRI>
<classLabel>Threonine/Tyrosine Protein Kinase</classLabel>
<newAxiom>&apos;Threonine/Tyrosine Protein Kinase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;</newAxiom>
<newAxiom>&apos;Threonine/Tyrosine Protein Kinase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18184</classIRI>
<classLabel>Histone Acetyltransferase Type B Catalytic Subunit</classLabel>
<deletedAxiom>&apos;Histone Acetyltransferase Type B Catalytic Subunit&apos; EquivalentTo &apos;Histone Acetylase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Acyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Acetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HAT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Acetyltransferase Type B Catalytic Subunit&apos; EquivalentTo &apos;Histone Acetylase&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Histone Acetylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HAT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18186</classIRI>
<classLabel>Hepatocyte Growth Factor Receptor</classLabel>
<deletedAxiom>&apos;Hepatocyte Growth Factor Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nectin Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Stabilization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Malaria Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MET Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Hepatocyte Growth Factor Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nectin Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophic Factor-Mediated NTRK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Retinoblastoma Protein Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38-alpha and p38-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Stabilization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Malaria Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MET Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18187</classIRI>
<classLabel>Probable ATP-Dependent RNA Helicase DDX6</classLabel>
<deletedAxiom>&apos;Probable ATP-Dependent RNA Helicase DDX6&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Helicase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDX6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Probable ATP-Dependent RNA Helicase DDX6&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DDX6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18183</classIRI>
<classLabel>Serine/Threonine-Protein Kinase STK11</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase STK11&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Peutz-Jeghers Syndrome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;STK11 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase STK11&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LKB1 Signaling Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Peutz-Jeghers Syndrome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;STK11 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97374</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase CCNB1IP1</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase CCNB1IP1&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNB1IP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase CCNB1IP1&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNB1IP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97377</classIRI>
<classLabel>Soluble Calcium-Activated Nucleotidase 1</classLabel>
<deletedAxiom>&apos;Soluble Calcium-Activated Nucleotidase 1&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CANT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Soluble Calcium-Activated Nucleotidase 1&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Purine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyrimidine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CANT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97371</classIRI>
<classLabel>Cysteinyl-tRNA Synthetase, Cytoplasmic</classLabel>
<deletedAxiom>&apos;Cysteinyl-tRNA Synthetase, Cytoplasmic&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aminoacyl-tRNA Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CARS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cysteinyl-tRNA Synthetase, Cytoplasmic&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aminoacyl-tRNA Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CARS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97368</classIRI>
<classLabel>Long-Chain-Fatty-Acid-CoA Ligase 3</classLabel>
<deletedAxiom>&apos;Long-Chain-Fatty-Acid-CoA Ligase 3&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Outer Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Peroxisome&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACSL3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Long-Chain-Fatty-Acid-CoA Ligase 3&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Outer Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Peroxisome&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACSL3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97383</classIRI>
<classLabel>G1/S-Specific Cyclin-D3</classLabel>
<deletedAxiom>&apos;G1/S-Specific Cyclin-D3&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Cyclin&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCND3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G1/S-Specific Cyclin-D3&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Progression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCND3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97386</classIRI>
<classLabel>Cyclin-Dependent Kinase 6</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 6&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 Phase Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 6&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2/STAT5 Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 Phase Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97380</classIRI>
<classLabel>Protein CASC5</classLabel>
<deletedAxiom>&apos;Protein CASC5&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centromere&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitotic/Spindle Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Prometaphase&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASC5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein CASC5&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centromere&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitotic/Spindle Checkpoint&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Prometaphase&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CASC5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18271</classIRI>
<classLabel>5,6-Dihydroxyindole-2-Carboxylic Acid Oxidase</classLabel>
<deletedAxiom>&apos;5,6-Dihydroxyindole-2-Carboxylic Acid Oxidase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Melanocyte&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Melanogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYRP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;5,6-Dihydroxyindole-2-Carboxylic Acid Oxidase&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Melanocyte&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Melanogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TYRP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18581</classIRI>
<classLabel>Securin</classLabel>
<deletedAxiom>&apos;Securin&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTTG1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Securin&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTTG1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112077</classIRI>
<classLabel>Proteasome Subunit Beta Type-8</classLabel>
<deletedAxiom>&apos;Proteasome Subunit Beta Type-8&apos; EquivalentTo &apos;Peptidase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proteasome Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Proteasome&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Dendritic Cell&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antigen Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PSMB8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Proteasome Subunit Beta Type-8&apos; EquivalentTo &apos;Peptidase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proteasome Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Proteasome&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Dendritic Cell&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Antigen Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PSMB8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18556</classIRI>
<classLabel>Tyrosine-Protein Kinase Yes</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Yes&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;YES1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Yes&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;YES1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18558</classIRI>
<classLabel>Tyrosine-Protein Kinase Hck</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Hck&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;B-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Granulocyte&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HCK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Hck&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;B-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Granulocyte&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Migration Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;HCK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18535</classIRI>
<classLabel>Serine/Threonine-Protein Kinase A-Raf</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase A-Raf&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ARAF Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase A-Raf&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DAG/PE-Binding Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ARAF Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18533</classIRI>
<classLabel>Abelson Tyrosine-Protein Kinase 2</classLabel>
<deletedAxiom>&apos;Abelson Tyrosine-Protein Kinase 2&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Branching Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ABL2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Abelson Tyrosine-Protein Kinase 2&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Branching Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Viral Myocarditis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ABL2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18487</classIRI>
<classLabel>Tumor Necrosis Factor Receptor Superfamily Member 1B</classLabel>
<deletedAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 1B&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Death Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF1B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 1B&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Death Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF1B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18488</classIRI>
<classLabel>Angiopoietin-1 Receptor</classLabel>
<deletedAxiom>&apos;Angiopoietin-1 Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Endothelium&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Extracellular Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TEK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Angiopoietin-1 Receptor&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Endothelium&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Extracellular Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TEK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112129</classIRI>
<classLabel>Dual Specificity Protein Phosphatase 4</classLabel>
<deletedAxiom>&apos;Dual Specificity Protein Phosphatase 4&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112317</classIRI>
<classLabel>Human Parainfluenza Virus 3</classLabel>
<deletedAxiom>&apos;Human Parainfluenza Virus 3&apos; SubClassOf &apos;Parainfluenza Virus&apos;</deletedAxiom>
<newAxiom>&apos;Human Parainfluenza Virus 3&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125641</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112316</classIRI>
<classLabel>Human Parainfluenza Virus 2</classLabel>
<deletedAxiom>&apos;Human Parainfluenza Virus 2&apos; SubClassOf &apos;Parainfluenza Virus&apos;</deletedAxiom>
<newAxiom>&apos;Human Parainfluenza Virus 2&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125641</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112318</classIRI>
<classLabel>Human Parainfluenza Virus 4</classLabel>
<deletedAxiom>&apos;Human Parainfluenza Virus 4&apos; SubClassOf &apos;Parainfluenza Virus&apos;</deletedAxiom>
<newAxiom>&apos;Human Parainfluenza Virus 4&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125641</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18600</classIRI>
<classLabel>Serine/Threonine-Protein Kinase Pim-1</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase Pim-1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Prostate Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Germ Cell&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Hematopoietic and Lymphoid Cell&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIM1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase Pim-1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Prostate Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Germ Cell&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Hematopoietic and Lymphoid Cell&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hematopoietic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PIM1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17525</classIRI>
<classLabel>Prostate-Specific Antigen</classLabel>
<deletedAxiom>&apos;Prostate-Specific Antigen&apos; EquivalentTo &apos;Kallikrein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Antigen Presentation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Biomarker_Of&apos; some &apos;Prostate Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KLK3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Prostate-Specific Antigen&apos; EquivalentTo &apos;Kallikrein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Antigen Presentation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Androgen Receptor Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Is_Biomarker_Of&apos; some &apos;Prostate Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KLK3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17528</classIRI>
<classLabel>Tyrosine-Protein Kinase CSK</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase CSK&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell to Cell Adhesion Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRC Tyrosine Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Receptor Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CSK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase CSK&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell to Cell Adhesion Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRC Tyrosine Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Immune Response Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Receptor Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CSK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17530</classIRI>
<classLabel>Insulin-Like Growth Factor Receptor</classLabel>
<deletedAxiom>&apos;Insulin-Like Growth Factor Receptor&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Growth Factor Receptor&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17575</classIRI>
<classLabel>Matrix Metalloproteinase-9</classLabel>
<deletedAxiom>&apos;Matrix Metalloproteinase-9&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Collagenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Degradation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Matrix Metalloproteinase-9&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-1-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Collagenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Degradation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17574</classIRI>
<classLabel>Tyrosine-Protein Kinase Fyn</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Fyn&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Aggregation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TCR Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TSP-1 Induced Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E-Cadherin Signaling Pathway in Keratinocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A Reverse Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nephrin Signaling Pathway in the Kidney Podocyte&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FYN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Fyn&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Platelet Aggregation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TCR Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TSP-1 Induced Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E-Cadherin Signaling Pathway in Keratinocytes&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A Reverse Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nephrin Signaling Pathway in the Kidney Podocyte&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-3-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FYN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17573</classIRI>
<classLabel>Cytochrome P450 3A4</classLabel>
<deletedAxiom>&apos;Cytochrome P450 3A4&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carcinogen Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP3A4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 3A4&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carcinogen Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP3A4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17572</classIRI>
<classLabel>Focal Adhesion Kinase 1</classLabel>
<deletedAxiom>&apos;Focal Adhesion Kinase 1&apos; EquivalentTo &apos;FAK Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell to Cell Adhesion Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-1 Cell Spread Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nectin Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Focal Adhesion Kinase 1&apos; EquivalentTo &apos;FAK Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell to Cell Adhesion Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-2 Cell Motility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calpain-1 Cell Spread Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A2 Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nectin Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17571</classIRI>
<classLabel>Stromelysin-1</classLabel>
<deletedAxiom>&apos;Stromelysin-1&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Wound Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Stromelysin-1&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP3 Gene&apos;</newAxiom>
<newAxiom>&apos;Stromelysin-1&apos; SubClassOf &apos;Matrix Metalloproteinase&apos;</newAxiom>
<newAxiom>&apos;Stromelysin-1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Wound Repair&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17542</classIRI>
<classLabel>Metalloproteinase Inhibitor 2</classLabel>
<deletedAxiom>&apos;Metalloproteinase Inhibitor 2&apos; EquivalentTo &apos;Tissue Inhibitor of Metalloproteinases&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Disease Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Matrix&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Tissue Inhibitor of Metalloproteinases&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TIMP2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Metalloproteinase Inhibitor 2&apos; EquivalentTo &apos;Tissue Inhibitor of Metalloproteinases&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Disease Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Matrix&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TIMP2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17543</classIRI>
<classLabel>Metalloproteinase Inhibitor 1</classLabel>
<deletedAxiom>&apos;Metalloproteinase Inhibitor 1&apos; EquivalentTo &apos;Tissue Inhibitor of Metalloproteinases&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Matrix&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Platelet&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Macrophage&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Tissue Inhibitor of Metalloproteinases&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Growth Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Erythropoiesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TIMP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Metalloproteinase Inhibitor 1&apos; EquivalentTo &apos;Tissue Inhibitor of Metalloproteinases&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Matrix&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Platelet&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Macrophage&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Growth Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Erythropoiesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TIMP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17548</classIRI>
<classLabel>Myeloblastin</classLabel>
<deletedAxiom>&apos;Myeloblastin&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Wegener Granulomatosis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Neutrophil&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRTN3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Myeloblastin&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Wegener Granulomatosis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Neutrophil&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRTN3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17589</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 1</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 1&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1R Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pelp1 Estrogen Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Splicing Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dorso-Ventral Axis Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 1&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuronal Survival Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1R Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pelp1 Estrogen Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Splicing Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mucosal Healing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dorso-Ventral Axis Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nongenotropic Androgen Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Presenilin Action in Notch and Wnt Signaling Pathways&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17580</classIRI>
<classLabel>RAC-Beta Serine/Threonine Kinase</classLabel>
<deletedAxiom>&apos;RAC-Beta Serine/Threonine Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin-Mediated Glucose Transport Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Ovarian Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase B&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AKT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAC-Beta Serine/Threonine Kinase&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin-Mediated Glucose Transport Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Ovarian Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase B&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carbohydrate Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AKT2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17586</classIRI>
<classLabel>Cyclin-Dependent Kinase Inhibitor 1C</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase Inhibitor 1C&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Pancreatic Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Thyroid Gland Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN1C Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase Inhibitor 1C&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Pancreatic Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Thyroid Gland Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN1C Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17590</classIRI>
<classLabel>Fibroblast Growth Factor Receptor 1</classLabel>
<deletedAxiom>&apos;Fibroblast Growth Factor Receptor 1&apos; EquivalentTo &apos;Fibroblast Growth Factor Receptor Family&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Myeloproliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGFR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fibroblast Growth Factor Receptor 1&apos; EquivalentTo &apos;Fibroblast Growth Factor Receptor Family&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;N-Cadherin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Myeloproliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FGFR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17592</classIRI>
<classLabel>72kDa Type IV Collagenase</classLabel>
<deletedAxiom>&apos;72kDa Type IV Collagenase&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;72kDa Type IV Collagenase&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiopoietin-1 Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Plasma Membrane Estrogen Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Collagenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17594</classIRI>
<classLabel>Stromelysin-3</classLabel>
<deletedAxiom>&apos;Stromelysin-3&apos; EquivalentTo &apos;Matrix Metalloproteinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP11 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Stromelysin-3&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MMP11 Gene&apos;</newAxiom>
<newAxiom>&apos;Stromelysin-3&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;</newAxiom>
<newAxiom>&apos;Stromelysin-3&apos; SubClassOf &apos;Matrix Metalloproteinase&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17596</classIRI>
<classLabel>Tyrosine-Protein Kinase ZAP-70</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase ZAP-70&apos; EquivalentTo &apos;syk Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TCR Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Severe Combined Immunodeficiency&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;T-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Natural Killer Cell&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ZAP70 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase ZAP-70&apos; EquivalentTo &apos;syk Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CSK Protein Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TCR Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Severe Combined Immunodeficiency&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;T-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Natural Killer Cell&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ZAP70 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111316</classIRI>
<classLabel>Small Nucleolar RNA</classLabel>
<newAxiom>&apos;Small Nucleolar RNA&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17664</classIRI>
<classLabel>Growth Factor Receptor</classLabel>
<deletedAxiom>&apos;Growth Factor Receptor&apos; SubClassOf &apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Cell Surface Receptor&apos;</deletedAxiom>
<deletedAxiom>&apos;Growth Factor Receptor&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor&apos;</deletedAxiom>
<newAxiom>&apos;Growth Factor Receptor&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17660</classIRI>
<classLabel>Receptor Tyrosine Kinase</classLabel>
<newAxiom>&apos;Receptor Tyrosine Kinase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17675</classIRI>
<classLabel>Antigen KI-67</classLabel>
<deletedAxiom>&apos;Antigen KI-67&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Proliferation Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Neoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;FHA Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MKI67 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Antigen KI-67&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Proliferation Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Neoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;FHA Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MKI67 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17673</classIRI>
<classLabel>Cytochrome P450 1A2</classLabel>
<deletedAxiom>&apos;Cytochrome P450 1A2&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caffeine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carcinogen Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Efflux&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP1A2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 1A2&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tryptophan Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lipid Metabolism and Toxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caffeine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Carcinogen Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Efflux&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP1A2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17685</classIRI>
<classLabel>Receptor Tyrosine-Protein Kinase ErbB-4</classLabel>
<deletedAxiom>&apos;Receptor Tyrosine-Protein Kinase ErbB-4&apos; EquivalentTo &apos;ErbB Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gamma-Secretase Mediated ErbB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Maturation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ERBB4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor Tyrosine-Protein Kinase ErbB-4&apos; EquivalentTo &apos;ErbB Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gamma-Secretase Mediated ErbB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Maturation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ERBB4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17681</classIRI>
<classLabel>Metalloproteinase Inhibitor 3</classLabel>
<deletedAxiom>&apos;Metalloproteinase Inhibitor 3&apos; EquivalentTo &apos;Tissue Inhibitor of Metalloproteinases&apos; and &apos;Angiogenesis Inhibitory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Matrix&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Tissue Inhibitor of Metalloproteinases&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TIMP3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Metalloproteinase Inhibitor 3&apos; EquivalentTo &apos;Tissue Inhibitor of Metalloproteinases&apos; and &apos;Angiogenesis Inhibitory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Matrix Metalloproteinases Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Matrix&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Angiogenic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TIMP3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17680</classIRI>
<classLabel>Cyclin-Dependent Kinase 4</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 4&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Melanoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 4&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Melanoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17698</classIRI>
<classLabel>Bcl-2-Like Protein 1</classLabel>
<deletedAxiom>&apos;Bcl-2-Like Protein 1&apos; EquivalentTo &apos;Apoptosis Regulator&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AIF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitochondria in Apoptotic Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Outer Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;BH1 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;BH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;BH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Inhibitor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCL2L1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Bcl-2-Like Protein 1&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125668 and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AIF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BAD Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2RB Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitochondria in Apoptotic Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Outer Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;BH1 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;BH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;BH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Apoptosis Inhibitor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BCL2L1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17697</classIRI>
<classLabel>Tyrosine-Protein Kinase Blk</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Blk&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Class I PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Reverse Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of p38-alpha and p38-beta Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;SRC Family Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BLK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Blk&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Class I PI3K Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Reverse Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of p38-alpha and p38-beta Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTPN1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BLK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17696</classIRI>
<classLabel>RAB8 Protein</classLabel>
<deletedAxiom>&apos;RAB8 Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RAS Superfamily Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAB8A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAB8 Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAB8A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17694</classIRI>
<classLabel>Cytochrome P450 2C18</classLabel>
<deletedAxiom>&apos;Cytochrome P450 2C18&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2C18 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 2C18&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2C18 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17691</classIRI>
<classLabel>Proto-Oncogene Tyrosine-Protein Kinase ROS</classLabel>
<deletedAxiom>&apos;Proto-Oncogene Tyrosine-Protein Kinase ROS&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ROS1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Proto-Oncogene Tyrosine-Protein Kinase ROS&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ROS1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17780</classIRI>
<classLabel>Mitogen-Activated Protein Kinase 8</classLabel>
<deletedAxiom>&apos;Mitogen-Activated Protein Kinase 8&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bone Remodeling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;4-1BB-Dependent Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mitogen-Activated Protein Kinase 8&apos; EquivalentTo &apos;Mitogen-Activated Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Agrin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL1R Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bone Remodeling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;4-1BB-Dependent Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Type II Diabetes Mellitus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epithelial Cell Signaling Pathway in Helicobacter pylori Infection&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAPK8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17784</classIRI>
<classLabel>Cyclin-Dependent Kinase 4 Inhibitor B</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 4 Inhibitor B&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN2B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 4 Inhibitor B&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN2B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17783</classIRI>
<classLabel>Cyclin-Dependent Kinase Inhibitor 1</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase Inhibitor 1&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Neuroprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of G1 Phase&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN1A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase Inhibitor 1&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Neuroprotection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of G1 Phase&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN1A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17786</classIRI>
<classLabel>Cyclin-Dependent Kinase Inhibitor 2A</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase Inhibitor 2A&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Melanoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Pancreatic Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of G1 Phase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN2A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase Inhibitor 2A&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Melanoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Pancreatic Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of G1 Phase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN2A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17785</classIRI>
<classLabel>Cyclin-Dependent Kinase 5</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 5&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FosB Drug-induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LIS1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Neuron&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokinesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 5&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CK1/CDK5 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FosB Drug-induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;LIS1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Neuron&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokinesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neural Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17799</classIRI>
<classLabel>Seprase</classLabel>
<deletedAxiom>&apos;Seprase&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Epithelial Cell&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Cytoplasmic Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FAP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Seprase&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Epithelial Cell&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Cytoplasmic Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Morphogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FAP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17796</classIRI>
<classLabel>Glutamate Carboxypeptidase 2</classLabel>
<deletedAxiom>&apos;Glutamate Carboxypeptidase 2&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Tumor-Associated Vasculature&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Folic Acid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transport Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FOLH1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Glutamate Carboxypeptidase 2&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Tumor-Associated Vasculature&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Folic Acid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transport Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FOLH1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17767</classIRI>
<classLabel>Cyclin-Dependent Kinase</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17773</classIRI>
<classLabel>Arylamine N-Acetyltransferase 2</classLabel>
<deletedAxiom>&apos;Arylamine N-Acetyltransferase 2&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caffeine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Acyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Acetylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NAT2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Arylamine N-Acetyltransferase 2&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caffeine Metabolism Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Acetylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NAT2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17736</classIRI>
<classLabel>Thyroid Hormone Receptor Beta</classLabel>
<deletedAxiom>&apos;Thyroid Hormone Receptor Beta&apos; EquivalentTo &apos;Thyroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Thyroid Hormone Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;THRB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Thyroid Hormone Receptor Beta&apos; EquivalentTo &apos;Thyroid Hormone Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;THRB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17813</classIRI>
<classLabel>Nuclear Receptor Subfamily 2 Group F Member 6</classLabel>
<deletedAxiom>&apos;Nuclear Receptor Subfamily 2 Group F Member 6&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR2F6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Nuclear Receptor Subfamily 2 Group F Member 6&apos; EquivalentTo &apos;Nuclear Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NR2F6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17802</classIRI>
<classLabel>DNA Topoisomerase 2-Beta</classLabel>
<deletedAxiom>&apos;DNA Topoisomerase 2-Beta&apos; EquivalentTo &apos;Topoisomerase II&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Expression Regulation by Vitamin D Receptor Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ATPase Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Topoisomerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Condensation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOP2B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Topoisomerase 2-Beta&apos; EquivalentTo &apos;Topoisomerase II&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Expression Regulation by Vitamin D Receptor Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ATPase Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Condensation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOP2B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17800</classIRI>
<classLabel>Tumor Necrosis Factor Receptor Superfamily Member 1A</classLabel>
<deletedAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 1A&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Resistance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RELA Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon Signaling Modulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Death Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Death Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF1A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 1A&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Resistance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RELA Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon Signaling Modulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adipocytokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Death Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Death Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF1A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17801</classIRI>
<classLabel>DNA Topoisomerase 2-Alpha</classLabel>
<deletedAxiom>&apos;DNA Topoisomerase 2-Alpha&apos; EquivalentTo &apos;Topoisomerase II&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptotic DNA Fragmentation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ATPase Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Topoisomerase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Condensation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOP2A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA Topoisomerase 2-Alpha&apos; EquivalentTo &apos;Topoisomerase II&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptotic DNA Fragmentation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ATPase Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromosome Condensation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TOP2A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17807</classIRI>
<classLabel>Prostasin</classLabel>
<deletedAxiom>&apos;Prostasin&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Salivary Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Bronchus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRSS8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Prostasin&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Prostate Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Salivary Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Bronchus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRSS8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17805</classIRI>
<classLabel>Protein Kinase C Alpha Type</classLabel>
<deletedAxiom>&apos;Protein Kinase C Alpha Type&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gamma-Secretase Mediated ErbB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channel and Phorbal Esters Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Kinase C Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Associated Cell Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRC Tyrosine Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Trka Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vibrio cholerae Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Downstream Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase C&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKCA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein Kinase C Alpha Type&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Attenuation of GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Hypertrophy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Receptor Downregulation by CBL Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;eIF4 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gamma-Secretase Mediated ErbB4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channel and Phorbal Esters Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Myosin Phosphatase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Kinase C Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Associated Cell Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipase C Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRC Tyrosine Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Trka Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vibrio cholerae Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aldosterone-Regulated Sodium Reabsorption Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Downstream Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling in the CD4+ TCR Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Syndecan-4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Protein Kinase C&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKCA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17804</classIRI>
<classLabel>Histone Acetyltransferase p300</classLabel>
<deletedAxiom>&apos;Histone Acetyltransferase p300&apos; EquivalentTo &apos;Histone Acetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CARM1 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia-Inducible Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanocyte Development Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pelp1 Estrogen Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Obesity and Thermogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RELA Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Expression Regulation by Vitamin D Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class III Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Histone Acetylase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Coactivator&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EP300 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone Acetyltransferase p300&apos; EquivalentTo &apos;Histone Acetylase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CARM1 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia-Inducible Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanocyte Development Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pelp1 Estrogen Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pitx2 Transcription Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Obesity and Thermogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RELA Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gene Expression Regulation by Vitamin D Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Wnt Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Nuclear SMAD2/3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class III Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Coactivator&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EP300 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17808</classIRI>
<classLabel>Dual Specificity Mitogen-Activated Protein Kinase Kinase 1</classLabel>
<deletedAxiom>&apos;Dual Specificity Mitogen-Activated Protein Kinase Kinase 1&apos; EquivalentTo &apos;Threonine/Tyrosine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Anthrax Toxin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Map Kinase Inactivation of SMRT Corepressor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1R Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP2K1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dual Specificity Mitogen-Activated Protein Kinase Kinase 1&apos; EquivalentTo &apos;Threonine/Tyrosine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prion Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Anthrax Toxin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Downregulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cadmium Induction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Extracellular Matrix Binding Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Map Kinase Inactivation of SMRT Corepressor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Formyl Peptide Receptor 1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Growth Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Inhibition of Cellular Proliferation by Gleevec Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G-Protein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Human Cytomegalovirus Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF-1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IGF1R Antiapoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL6 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFAT Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aspirin Inhibition of Platelet Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sprouty Regulation of Tyrosine Kinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF Beta Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TPO Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Small Cell Lung Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pancreatic Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B Cell Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Colorectal Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Epsilon Receptor I Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Melanoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glioblastoma Multiforme Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Papillary Thyroid Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostate Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endometrial Cancer Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MAP2K1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17991</classIRI>
<classLabel>Diamine Acetyltransferase 1</classLabel>
<deletedAxiom>&apos;Diamine Acetyltransferase 1&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Acyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyamine Catabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SAT1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Diamine Acetyltransferase 1&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyamine Catabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SAT1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17984</classIRI>
<classLabel>Prostaglandin G/H Synthase 2</classLabel>
<deletedAxiom>&apos;Prostaglandin G/H Synthase 2&apos; EquivalentTo &apos;Cyclooxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostaglandin and Leukotriene Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acetaminophen Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclooxygenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTGS2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Prostaglandin G/H Synthase 2&apos; EquivalentTo &apos;Cyclooxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostaglandin and Leukotriene Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acetaminophen Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;EGF-Like Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTGS2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17986</classIRI>
<classLabel>Disintegrin and Metalloproteinase Domain-Containing Protein 15</classLabel>
<deletedAxiom>&apos;Disintegrin and Metalloproteinase Domain-Containing Protein 15&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;ADAM Family Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADAM Type Metalloprotease Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Extracellular Matrix Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAM15 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Disintegrin and Metalloproteinase Domain-Containing Protein 15&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;ADAM Family Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ADAM Type Metalloprotease Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Extracellular Matrix Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAM15 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17988</classIRI>
<classLabel>G1/S-Specific Cyclin-D1</classLabel>
<deletedAxiom>&apos;G1/S-Specific Cyclin-D1&apos; EquivalentTo &apos;CCND1 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BTG Cell Cycle Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Cyclin D1 Protein Overexpression&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCND1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G1/S-Specific Cyclin-D1&apos; EquivalentTo &apos;CCND1 Gene Product&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BTG Cell Cycle Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Estrogen Receptor Regulation by CARM1 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;WNT Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Cyclin D1 Protein Overexpression&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Marker&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCND1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17980</classIRI>
<classLabel>Bloom Syndrome Protein</classLabel>
<deletedAxiom>&apos;Bloom Syndrome Protein&apos; EquivalentTo &apos;RecQ Helicase Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Homologous Recombination Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Helicase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BLM Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Bloom Syndrome Protein&apos; EquivalentTo &apos;RecQ Helicase Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Homologous Recombination Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BLM Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17981</classIRI>
<classLabel>G2/Mitotic-Specific Cyclin-B1</classLabel>
<deletedAxiom>&apos;G2/Mitotic-Specific Cyclin-B1&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ptc1 Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRC Tyrosine Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Laryngeal Squamous Cell Carcinoma&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;M-Phase Promoting Factor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNB1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G2/Mitotic-Specific Cyclin-B1&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AKAP8 in Mitosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ptc1 Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRC Tyrosine Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Laryngeal Squamous Cell Carcinoma&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;M-Phase Promoting Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNB1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17928</classIRI>
<classLabel>Centromere Protein F</classLabel>
<deletedAxiom>&apos;Centromere Protein F&apos; EquivalentTo &apos;Nuclear Matrix Protein&apos; and &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Proliferation Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CENPF Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Centromere Protein F&apos; EquivalentTo &apos;Nuclear Matrix Protein&apos; and &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Proliferation Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Division Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CENPF Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17924</classIRI>
<classLabel>Serine-Protein Kinase ATM</classLabel>
<deletedAxiom>&apos;Serine-Protein Kinase ATM&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cancer Susceptibility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDC25 and CHK1 Regulatory Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BARD1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Ataxia Telangiectasia Syndrome&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Leukemia&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lymphoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Differentiation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ATM Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine-Protein Kinase ATM&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATM Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cancer Susceptibility Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDC25 and CHK1 Regulatory Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis DNA Damage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Progression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RB Checkpoint Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BARD1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Ataxia Telangiectasia Syndrome&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Leukemia&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lymphoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Differentiation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ATM Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17923</classIRI>
<classLabel>Receptor-Interacting Serine/Threonine-Protein Kinase 1</classLabel>
<deletedAxiom>&apos;Receptor-Interacting Serine/Threonine-Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RELA Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Stress Related Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytosolic DNA-Sensing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of p38-alpha and p38-beta Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TRAIL Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Death Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RIPK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Interacting Serine/Threonine-Protein Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;DR3 and DR4/5 Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Keratinocyte Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RELA Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SODD/TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Stress Related Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytosolic DNA-Sensing Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Caspase Cascade in Apoptosis&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FAS Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of p38-alpha and p38-beta Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNF Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TRAIL Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Death Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RIPK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17936</classIRI>
<classLabel>NAD(P)H Dehydrogenase [Quinone] 1</classLabel>
<deletedAxiom>&apos;NAD(P)H Dehydrogenase [Quinone] 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sterol Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquinone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Quinone Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NQO1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;NAD(P)H Dehydrogenase [Quinone] 1&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sterol Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquinone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypoxia Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Quinone Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NQO1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17902</classIRI>
<classLabel>Furin</classLabel>
<deletedAxiom>&apos;Furin&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Proteolysis and Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FURIN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Furin&apos; EquivalentTo &apos;Serine Protease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Notch Proteolysis and Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glypican 3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolytic Processing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FURIN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17901</classIRI>
<classLabel>Cyclin-Dependent Kinase Inhibitor 1B</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase Inhibitor 1B&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDK Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Marker&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN1B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase Inhibitor 1B&apos; EquivalentTo &apos;Cyclin-Dependent Kinase Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CTCF Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDK Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Prognostic Marker&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDKN1B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17914</classIRI>
<classLabel>ATP-Dependent DNA Helicase Q1</classLabel>
<deletedAxiom>&apos;ATP-Dependent DNA Helicase Q1&apos; EquivalentTo &apos;RecQ Helicase Family Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Helicase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RECQL Gene&apos;)</deletedAxiom>
<newAxiom>&apos;ATP-Dependent DNA Helicase Q1&apos; EquivalentTo &apos;RecQ Helicase Family Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Topology Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RECQL Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17911</classIRI>
<classLabel>Serine/Threonine-Protein Kinase PLK1</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase PLK1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXO Transcription Factor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Spindle Pole Body&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Polo-Box Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokinesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase PLK1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Progesterone-Mediated Oocyte Maturation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXM1 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXO Transcription Factor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK1 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Spindle Pole Body&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Polo-Box Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokinesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Mitosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17978</classIRI>
<classLabel>Protein-Tyrosine Kinase 2-Beta</classLabel>
<deletedAxiom>&apos;Protein-Tyrosine Kinase 2-Beta&apos; EquivalentTo &apos;FAK Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HBx Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channel and Phorbal Esters Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endothelin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTK2B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein-Tyrosine Kinase 2-Beta&apos; EquivalentTo &apos;FAK Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Angiotensin II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bioactive Peptide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR5 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HBx Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL7 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ion Channel and Phorbal Esters Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ras-Independent Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thrombin/Protease-Activated Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Natural Killer Cell-Mediated Cytotoxicity Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alpha-Synuclein Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endothelin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FGF Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL2-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Angiogenesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Osteopontin-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;VEGFR1 and VEGFR2 Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PTK2B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17956</classIRI>
<classLabel>Cytochrome P450 19A1</classLabel>
<deletedAxiom>&apos;Cytochrome P450 19A1&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Endometriosis&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Gynecomastia&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Aromatase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Maturation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Estrogen Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP19A1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 19A1&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Endometriosis&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Gynecomastia&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Aromatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Maturation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Estrogen Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP19A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97970</classIRI>
<classLabel>Interleukin-17 Receptor B</classLabel>
<deletedAxiom>&apos;Interleukin-17 Receptor B&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Interleukin Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL17RB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interleukin-17 Receptor B&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Interleukin Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL17RB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97866</classIRI>
<classLabel>Tubulin-Tyrosine Ligase</classLabel>
<deletedAxiom>&apos;Tubulin-Tyrosine Ligase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97860</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase TRIM33</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase TRIM33&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;TRIM Family&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;TRIM Motif&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIM33 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase TRIM33&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;TRIM Family&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;TRIM Motif&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIM33 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97896</classIRI>
<classLabel>Platelet-Activating Factor Acetylhydrolase IB Subunit Beta</classLabel>
<deletedAxiom>&apos;Platelet-Activating Factor Acetylhydrolase IB Subunit Beta&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ether Lipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lissencephaly-1 Gene in Neuronal Migration and Development&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Esterase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAFAH1B2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Platelet-Activating Factor Acetylhydrolase IB Subunit Beta&apos; EquivalentTo &apos;Esterase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ether Lipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lissencephaly-1 Gene in Neuronal Migration and Development&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PAFAH1B2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97893</classIRI>
<classLabel>Centriolin</classLabel>
<deletedAxiom>&apos;Centriolin&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centrosome&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G2 to M Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CNTRL Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Centriolin&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centrosome&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G2 to M Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CNTRL Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97845</classIRI>
<classLabel>Tumor Necrosis Factor Receptor Superfamily Member 14</classLabel>
<deletedAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 14&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF14 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 14&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF14 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97848</classIRI>
<classLabel>Tumor Necrosis Factor Receptor Superfamily Member 17</classLabel>
<deletedAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 17&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF17 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tumor Necrosis Factor Receptor Superfamily Member 17&apos; EquivalentTo &apos;TNF Receptor Family Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;B-Cell Immune Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokine Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNFRSF17 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97799</classIRI>
<classLabel>SLIT-ROBO Rho GTPase-Activating Protein 3</classLabel>
<deletedAxiom>&apos;SLIT-ROBO Rho GTPase-Activating Protein 3&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase-Activating Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SRGAP3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;SLIT-ROBO Rho GTPase-Activating Protein 3&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Signaling Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SRGAP3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97775</classIRI>
<classLabel>Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial</classLabel>
<deletedAxiom>&apos;Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Citrate Cycle (TCA Cycle) Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Phosphorylation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Electron Transport Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Inner Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Succinate Dehydrogenase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Respiration&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SDHB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Citrate Cycle (TCA Cycle) Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Phosphorylation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Electron Transport Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Inner Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Succinate Dehydrogenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Respiration&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SDHB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111930</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase UBR5</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase UBR5&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBR5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase UBR5&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;UBR5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111933</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase RNF130</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase RNF130&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNF130 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase RNF130&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNF130 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111936</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase Makorin-1</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase Makorin-1&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C3H1 Zinc Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MKRN1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase Makorin-1&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C3H1 Zinc Finger&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitinated Protein Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MKRN1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111864</classIRI>
<classLabel>Dual Specificity Protein Phosphatase 5</classLabel>
<deletedAxiom>&apos;Dual Specificity Protein Phosphatase 5&apos; EquivalentTo &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DUSP5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dual Specificity Protein Phosphatase 5&apos; EquivalentTo &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Dephosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DUSP5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97600</classIRI>
<classLabel>Lysine-Specific Demethylase 5C</classLabel>
<deletedAxiom>&apos;Lysine-Specific Demethylase 5C&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ARID Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KDM5C Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Lysine-Specific Demethylase 5C&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ARID Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PHD Finger&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Chromatin Remodeling Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KDM5C Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21594</classIRI>
<classLabel>Thiopurine S-Methyltransferase</classLabel>
<deletedAxiom>&apos;Thiopurine S-Methyltransferase&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Thiopurine Methyltransferase Deficiency&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Methylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TPMT Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Thiopurine S-Methyltransferase&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Thiopurine Methyltransferase Deficiency&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Methylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Drug Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TPMT Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21598</classIRI>
<classLabel>Gastrin/Cholecystokinin Type B Receptor</classLabel>
<deletedAxiom>&apos;Gastrin/Cholecystokinin Type B Receptor&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Digestion&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Sensory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stimulation of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCKBR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Gastrin/Cholecystokinin Type B Receptor&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Digestion&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Sensory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stimulation of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCKBR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21590</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase CBL-B</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin-Protein Ligase CBL-B&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40/CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Regulated NFAT-Dependent Transcription Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Autoimmune Disease&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Type 1 Diabetes Mellitus&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CBLB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin-Protein Ligase CBL-B&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chronic Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Jak-STAT Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40/CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcineurin-Regulated NFAT-Dependent Transcription Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bacterial Invasion of Epithelial Cell Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Autoimmune Disease&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Type 1 Diabetes Mellitus&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CBLB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111846</classIRI>
<classLabel>Tissue Factor Pathway Inhibitor 2</classLabel>
<deletedAxiom>&apos;Tissue Factor Pathway Inhibitor 2&apos; EquivalentTo &apos;Serine Proteinase Inhibitor Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Blood&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Proteinase Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Coagulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Enzyme Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TFPI2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tissue Factor Pathway Inhibitor 2&apos; EquivalentTo &apos;Serine Proteinase Inhibitor Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Blood&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Coagulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Enzyme Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TFPI2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21443</classIRI>
<classLabel>Vasoactive Intestinal Polypeptide Receptor 1</classLabel>
<deletedAxiom>&apos;Vasoactive Intestinal Polypeptide Receptor 1&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Immune System&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Respiratory System&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Digestion&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Muscle Contraction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;VIPR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Vasoactive Intestinal Polypeptide Receptor 1&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Colon&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Immune System&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Respiratory System&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Digestion&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Muscle Contraction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;VIPR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21440</classIRI>
<classLabel>Ubiquitin Carboxyl-Terminal Hydrolase 8</classLabel>
<deletedAxiom>&apos;Ubiquitin Carboxyl-Terminal Hydrolase 8&apos; EquivalentTo &apos;Cysteine Proteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Myeloproliferative Neoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitin C-Terminal Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;USP8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ubiquitin Carboxyl-Terminal Hydrolase 8&apos; EquivalentTo &apos;Cysteine Proteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB2/ERBB3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Myeloproliferative Neoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitin C-Terminal Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;USP8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21487</classIRI>
<classLabel>GTP-Binding Protein Di-Ras3</classLabel>
<deletedAxiom>&apos;GTP-Binding Protein Di-Ras3&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Breast&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RHO Effector Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Membrane Localization Motif&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Small G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DIRAS3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;GTP-Binding Protein Di-Ras3&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Breast&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RHO Effector Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Membrane Localization Motif&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DIRAS3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21483</classIRI>
<classLabel>DNA-Dependent Protein Kinase Catalytic Subunit</classLabel>
<deletedAxiom>&apos;DNA-Dependent Protein Kinase Catalytic Subunit&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;DNA Repair Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Homologous End-Joining Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BARD1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nonhomologous DNA End Joining&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Telomere Capping&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;V(D)J Recombination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKDC Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA-Dependent Protein Kinase Catalytic Subunit&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;DNA Repair Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G2/M Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Non-Homologous End-Joining Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BARD1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PI3K/AKT1 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Coregulation Pathway for Androgen Receptor Activity&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nonhomologous DNA End Joining&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Telomere Capping&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;V(D)J Recombination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PRKDC Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29909</classIRI>
<classLabel>Ribosomal Protein S6 Kinase Alpha-5</classLabel>
<deletedAxiom>&apos;Ribosomal Protein S6 Kinase Alpha-5&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RPS6KA5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ribosomal Protein S6 Kinase Alpha-5&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CREB Activation Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erk1/Erk2 MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p38 MAPK Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bladder Cancer Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysophosphatidic Acid Receptor 4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RPS6KA5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29911</classIRI>
<classLabel>Ribosomal Protein S6 Kinase Beta-2</classLabel>
<deletedAxiom>&apos;Ribosomal Protein S6 Kinase Beta-2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RPS6KB2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ribosomal Protein S6 Kinase Beta-2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPKinase Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;mTOR Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ERBB Family Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Acute Myeloid Leukemia Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Phosphorylation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RPS6KB2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29940</classIRI>
<classLabel>Histone-Lysine N-Methyltransferase SETDB1</classLabel>
<deletedAxiom>&apos;Histone-Lysine N-Methyltransferase SETDB1&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysine Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Methyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gene Expression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SETDB1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Histone-Lysine N-Methyltransferase SETDB1&apos; EquivalentTo &apos;Methyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysine Degradation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Gene Expression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chromatin Remodeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Methylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SETDB1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29922</classIRI>
<classLabel>LIM Domain Kinase 1</classLabel>
<deletedAxiom>&apos;LIM Domain Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rho Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;LIM Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LIMK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;LIM Domain Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CCR3 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;SRF Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rac1 Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Rho Cell Motility Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc Gamma Receptor-Mediated Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;LIM Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LIMK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29920</classIRI>
<classLabel>Tyrosine-Protein Kinase RYK</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase RYK&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RYK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase RYK&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RYK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29939</classIRI>
<classLabel>Protein SET</classLabel>
<deletedAxiom>&apos;Protein SET&apos; EquivalentTo &apos;Enzyme Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Granzyme A Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Enzyme Inhibitor Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SET Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein SET&apos; EquivalentTo &apos;Enzyme Inhibitor Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Granzyme A Mediated Apoptosis Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SET Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29937</classIRI>
<classLabel>Serpin I2</classLabel>
<deletedAxiom>&apos;Serpin I2&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Enzyme Inhibitor Protein&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29931</classIRI>
<classLabel>Secretin Receptor</classLabel>
<deletedAxiom>&apos;Secretin Receptor&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SCTR Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Secretin Receptor&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Homeostatic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SCTR Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29998</classIRI>
<classLabel>Hsc70-Interacting Protein</classLabel>
<deletedAxiom>&apos;Hsc70-Interacting Protein&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ST13 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Hsc70-Interacting Protein&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Folding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ST13 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29991</classIRI>
<classLabel>Serine/Threonine-Protein Kinase PLK2</classLabel>
<deletedAxiom>&apos;Serine/Threonine-Protein Kinase PLK2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK2 and PLK4 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centriole&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Polo-Box Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Serine/Threonine-Protein Kinase PLK2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PLK2 and PLK4 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centriole&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Polo-Box Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PLK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29980</classIRI>
<classLabel>Smoothened Homolog</classLabel>
<deletedAxiom>&apos;Smoothened Homolog&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sonic Hedgehog Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMO Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Smoothened Homolog&apos; EquivalentTo &apos;G Protein-Coupled Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sonic Hedgehog Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G Protein-Coupled Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SMO Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29972</classIRI>
<classLabel>S-Phase Kinase-Associated Protein 2</classLabel>
<deletedAxiom>&apos;S-Phase Kinase-Associated Protein 2&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F1 Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SKP2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;S-Phase Kinase-Associated Protein 2&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ubiquitin-mediated Proteolysis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F1 Degradation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SKP2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29971</classIRI>
<classLabel>Helicase SKI2W</classLabel>
<deletedAxiom>&apos;Helicase SKI2W&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;RNA Helicase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SKIV2L Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Helicase SKI2W&apos; EquivalentTo &apos;RNA Helicase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RNA Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SKIV2L Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21516</classIRI>
<classLabel>Glutaminase Liver Isoform, Mitochondrial</classLabel>
<deletedAxiom>&apos;Glutaminase Liver Isoform, Mitochondrial&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D-Glutamine and D-Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proximal Tubule Bicarbonate Reclamation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Mitochondrial Import Sequence&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GLS2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Glutaminase Liver Isoform, Mitochondrial&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;D-Glutamine and D-Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alanine, Aspartate and Glutamate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proximal Tubule Bicarbonate Reclamation Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Mitochondrial Import Sequence&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GLS2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21539</classIRI>
<classLabel>Complement C5</classLabel>
<deletedAxiom>&apos;Complement C5&apos; EquivalentTo &apos;Complement Component Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Classical Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Granulocyte Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Local Acute Inflammatory Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lectin Induced Complement Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;C5 Deficiency&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Complement Component Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chemotactic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Complement Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;C5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Complement C5&apos; EquivalentTo &apos;Complement Component Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Classical Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Granulocyte Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Local Acute Inflammatory Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lectin Induced Complement Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;C5 Deficiency&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Chemotactic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stress Response Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Complement Activation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;C5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21523</classIRI>
<classLabel>Complement Component Protein</classLabel>
<deletedAxiom>&apos;Complement Component Protein&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;</deletedAxiom>
<newAxiom>&apos;Complement Component Protein&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Complement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21527</classIRI>
<classLabel>Complement C3</classLabel>
<deletedAxiom>&apos;Complement C3&apos; EquivalentTo &apos;Complement Component Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Classical Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Local Acute Inflammatory Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lectin Induced Complement Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;C3 Deficiency&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Complement Component Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Host Defense Mechanism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;C3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Complement C3&apos; EquivalentTo &apos;Complement Component Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alternative Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Classical Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Complement Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Local Acute Inflammatory Response Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lectin Induced Complement Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;C3 Deficiency&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Host Defense Mechanism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;C3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21336</classIRI>
<classLabel>Arachidonate 15-Lipoxygenase</classLabel>
<deletedAxiom>&apos;Arachidonate 15-Lipoxygenase&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostaglandin and Leukotriene Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALOX15 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Arachidonate 15-Lipoxygenase&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Prostaglandin and Leukotriene Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inflammatory Response&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALOX15 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21332</classIRI>
<classLabel>Sister Chromatid Cohesion Protein PDS5 Homolog B</classLabel>
<deletedAxiom>&apos;Sister Chromatid Cohesion Protein PDS5 Homolog B&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine Zipper&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DNA Binding Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Epithelial Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDS5B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Sister Chromatid Cohesion Protein PDS5 Homolog B&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine Zipper&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;DNA Binding Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Epithelial Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDS5B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21331</classIRI>
<classLabel>Aflatoxin B1 Aldehyde Reductase Member 2</classLabel>
<deletedAxiom>&apos;Aflatoxin B1 Aldehyde Reductase Member 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AKR7A2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Aflatoxin B1 Aldehyde Reductase Member 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oxidative Stress Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AKR7A2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21334</classIRI>
<classLabel>Anti-Muellerian Hormone Type-2 Receptor</classLabel>
<deletedAxiom>&apos;Anti-Muellerian Hormone Type-2 Receptor&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Sertoli Cell&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Hormone Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AMHR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Anti-Muellerian Hormone Type-2 Receptor&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Sertoli Cell&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Hormone Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AMHR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21330</classIRI>
<classLabel>Retinal Dehydrogenase 2</classLabel>
<deletedAxiom>&apos;Retinal Dehydrogenase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;T Acute Lymphoblastic Leukemia&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;GXGXXXG Motif&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryonic Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALDH1A2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Retinal Dehydrogenase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;T Acute Lymphoblastic Leukemia&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;GXGXXXG Motif&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryonic Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALDH1A2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21341</classIRI>
<classLabel>Activated CDC42 Kinase 1</classLabel>
<deletedAxiom>&apos;Activated CDC42 Kinase 1&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Coated Pit&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Activated CDC42 Kinase 1&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Coated Pit&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Tyrosine Kinase Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;UBA Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21340</classIRI>
<classLabel>RAS Homolog Gene Family Member H Protein</classLabel>
<deletedAxiom>&apos;RAS Homolog Gene Family Member H Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Hematopoietic Stem Cell&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Small G Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOH Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAS Homolog Gene Family Member H Protein&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Hematopoietic Stem Cell&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RHOH Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21369</classIRI>
<classLabel>Bone Morphogenetic Protein Receptor Type-2</classLabel>
<deletedAxiom>&apos;Bone Morphogenetic Protein Receptor Type-2&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BMPR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Bone Morphogenetic Protein Receptor Type-2&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Embryogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ligand Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BMPR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21367</classIRI>
<classLabel>Bone Morphogenetic Protein Receptor Type-1A</classLabel>
<deletedAxiom>&apos;Bone Morphogenetic Protein Receptor Type-1A&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Cowden Syndrome&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Juvenile Polyposis Syndrome&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Striated Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BMPR1A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Bone Morphogenetic Protein Receptor Type-1A&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ALK Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BMP Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Cowden Syndrome&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Juvenile Polyposis Syndrome&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Striated Muscle Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BMPR1A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21380</classIRI>
<classLabel>Protein BTG2</classLabel>
<deletedAxiom>&apos;Protein BTG2&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BTG Cell Cycle Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Chronic Lymphocytic Leukemia&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BTG2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Protein BTG2&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;BTG Cell Cycle Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Chronic Lymphocytic Leukemia&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;BTG2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21384</classIRI>
<classLabel>Beta-Adrenergic Receptor Kinase 2</classLabel>
<deletedAxiom>&apos;Beta-Adrenergic Receptor Kinase 2&apos; EquivalentTo (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADRBK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Beta-Adrenergic Receptor Kinase 2&apos; EquivalentTo (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Olfactory Transduction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADRBK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21382</classIRI>
<classLabel>Beta-Adrenergic Receptor Kinase 1</classLabel>
<deletedAxiom>&apos;Beta-Adrenergic Receptor Kinase 1&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Desensitization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADRBK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Beta-Adrenergic Receptor Kinase 1&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Desensitization Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;GPCR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class II Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Thromboxane A2 Receptor Family Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;PH Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RGS Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADRBK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21414</classIRI>
<classLabel>G1/S-Specific Cyclin-E1</classLabel>
<deletedAxiom>&apos;G1/S-Specific Cyclin-E1&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin E Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDK Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F1 Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Cyclin E Protein Overexpression&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Sertoli Cell&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cyclin&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNE1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;G1/S-Specific Cyclin-E1&apos; EquivalentTo &apos;Cyclin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin Regulation of Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cyclin E Degradation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1/S Checkpoint Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CDK Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p27 Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;G1 to S Transition Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;E2F1 Degradation Pathway&apos;) and (&apos;Gene_Product_Has_Abnormality&apos; some &apos;Cyclin E Protein Overexpression&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Sertoli Cell&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;G1 to S Transition Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CCNE1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21439</classIRI>
<classLabel>Ubiquitin Carboxyl-Terminal Hydrolase 6</classLabel>
<deletedAxiom>&apos;Ubiquitin Carboxyl-Terminal Hydrolase 6&apos; EquivalentTo &apos;Cysteine Proteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitin C-Terminal Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;USP6 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ubiquitin Carboxyl-Terminal Hydrolase 6&apos; EquivalentTo &apos;Cysteine Proteinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arf6 Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitin C-Terminal Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Deubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;USP6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21436</classIRI>
<classLabel>Tyrosine-tRNA Ligase, Cytoplasmic</classLabel>
<deletedAxiom>&apos;Tyrosine-tRNA Ligase, Cytoplasmic&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aminoacyl-tRNA Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phenylalanine, Tyrosine and Tryptophan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;YARS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-tRNA Ligase, Cytoplasmic&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Aminoacyl-tRNA Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phenylalanine, Tyrosine and Tryptophan Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Translation Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;YARS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21435</classIRI>
<classLabel>Interleukin-27 Receptor Subunit Alpha</classLabel>
<deletedAxiom>&apos;Interleukin-27 Receptor Subunit Alpha&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL27-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Natural Killer Cell&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;CD4-Positive T-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Type 1 Helper Cell&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Type 2 Helper Cell&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytokine Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL27RA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interleukin-27 Receptor Subunit Alpha&apos; EquivalentTo &apos;Cytokine Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL27-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Spleen&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Thymus Gland&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Natural Killer Cell&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;CD4-Positive T-Lymphocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Type 1 Helper Cell&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Type 2 Helper Cell&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intercellular Communication Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IL27RA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21423</classIRI>
<classLabel>DNA-(Apurinic or Apyrimidinic Site) Lyase 2</classLabel>
<deletedAxiom>&apos;DNA-(Apurinic or Apyrimidinic Site) Lyase 2&apos; EquivalentTo &apos;Class II AP Endonuclease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Base Excision Repair Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Class II AP Endonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Base Excision Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;APEX2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;DNA-(Apurinic or Apyrimidinic Site) Lyase 2&apos; EquivalentTo &apos;Class II AP Endonuclease&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Base Excision Repair Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrion&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;DNA Repair Endonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Base Excision Repair&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;APEX2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21272</classIRI>
<classLabel>Activin Receptor Type-2A</classLabel>
<deletedAxiom>&apos;Activin Receptor Type-2A&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Serine/Threonine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVR2A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Activin Receptor Type-2A&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVR2A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21274</classIRI>
<classLabel>Activin Receptor Type-2B</classLabel>
<deletedAxiom>&apos;Activin Receptor Type-2B&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Serine/Threonine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVR2B Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Activin Receptor Type-2B&apos; EquivalentTo &apos;Receptor Serine/Threonine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytokine-Cytokine Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-beta Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Pattern Formation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACVR2B Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21279</classIRI>
<classLabel>A Disintegrin and Metalloprotease with Thrombospondin Motifs 9</classLabel>
<deletedAxiom>&apos;A Disintegrin and Metalloprotease with Thrombospondin Motifs 9&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Peptidase Family M12B&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Matrix&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Fetus&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Disintegrin Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Metalloproteinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Maturation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Turnover&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAMTS9 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;A Disintegrin and Metalloprotease with Thrombospondin Motifs 9&apos; EquivalentTo &apos;Metalloproteinase&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Peptidase Family M12B&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Matrix&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Fetus&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Disintegrin Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Maturation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein Turnover&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ADAMTS9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21254</classIRI>
<classLabel>E3 Ubiquitin Ligase</classLabel>
<newAxiom>&apos;E3 Ubiquitin Ligase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21251</classIRI>
<classLabel>E3 Ubiquitin/ISG15 Ligase TRIM25</classLabel>
<deletedAxiom>&apos;E3 Ubiquitin/ISG15 Ligase TRIM25&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EFP Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;TRIM Motif&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;E3 Ubiquitin Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of G2 to M Transition&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stimulation of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Uterine Swelling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIM25 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;E3 Ubiquitin/ISG15 Ligase TRIM25&apos; EquivalentTo &apos;E3 Ubiquitin Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;EFP Cell Cycle Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;RIG-I-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ring Finger Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;TRIM Motif&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of G2 to M Transition&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Stimulation of Cell Proliferation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Uterine Swelling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TRIM25 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21237</classIRI>
<classLabel>Tumor Susceptibility Gene 101 Protein</classLabel>
<deletedAxiom>&apos;Tumor Susceptibility Gene 101 Protein&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glucocorticoid Receptor Regulatory Network&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Striated Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Vacuolar Protein Sorting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TSG101 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tumor Susceptibility Gene 101 Protein&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Stathmin Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Endocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glucocorticoid Receptor Regulatory Network&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Internalization Pathway for Epidermal Growth Factor Receptor&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Pancreas&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Kidney&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Striated Muscle Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lung&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Placenta&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Growth Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Vacuolar Protein Sorting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TSG101 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21207</classIRI>
<classLabel>Prohibitin</classLabel>
<deletedAxiom>&apos;Prohibitin&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Sporadic Breast Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Breast&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Muscle&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PHB Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Prohibitin&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Sporadic Breast Carcinoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Breast&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Muscle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Synthesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PHB Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103895</classIRI>
<classLabel>Alkaline Ceramidase 2</classLabel>
<deletedAxiom>&apos;Alkaline Ceramidase 2&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell-Matrix Adhesion&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Cell Death&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACER2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Alkaline Ceramidase 2&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell-Matrix Adhesion&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Positive Regulation of Cell Death&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACER2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103898</classIRI>
<classLabel>Alkaline Ceramidase 3</classLabel>
<deletedAxiom>&apos;Alkaline Ceramidase 3&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACER3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Alkaline Ceramidase 3&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Golgi Apparatus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACER3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103892</classIRI>
<classLabel>Alkaline Ceramidase 1</classLabel>
<deletedAxiom>&apos;Alkaline Ceramidase 1&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACER1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Alkaline Ceramidase 1&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACER1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103887</classIRI>
<classLabel>Acetyl-CoA Carboxylase 1</classLabel>
<deletedAxiom>&apos;Acetyl-CoA Carboxylase 1&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Propanoate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyruvate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Resistance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACACA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Acetyl-CoA Carboxylase 1&apos; EquivalentTo &apos;Ligase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Propanoate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyruvate Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin Resistance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Insulin/Insulin Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Triglyceride Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACACA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103901</classIRI>
<classLabel>Acid Ceramidase</classLabel>
<deletedAxiom>&apos;Acid Ceramidase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lumen of the Lysosome&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ASAH1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Acid Ceramidase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phospholipid Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ceramide Signaling Pathway PID&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Lumen of the Lysosome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ASAH1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103904</classIRI>
<classLabel>Neutral Ceramidase</classLabel>
<deletedAxiom>&apos;Neutral Ceramidase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ASAH2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Neutral Ceramidase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sphingoglycolipid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ASAH2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103989</classIRI>
<classLabel>Carbonyl Reductase [NADPH] 3</classLabel>
<deletedAxiom>&apos;Carbonyl Reductase [NADPH] 3&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Quinone Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CBR3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Carbonyl Reductase [NADPH] 3&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Quinone Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CBR3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103986</classIRI>
<classLabel>Ribosyldihydronicotinamide Dehydrogenase [Quinone]</classLabel>
<deletedAxiom>&apos;Ribosyldihydronicotinamide Dehydrogenase [Quinone]&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103945</classIRI>
<classLabel>Gamma-Glutamyl Hydrolase</classLabel>
<deletedAxiom>&apos;Gamma-Glutamyl Hydrolase&apos; EquivalentTo &apos;Peptidase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Folate Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Peptidase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Folic Acid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GGH Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Gamma-Glutamyl Hydrolase&apos; EquivalentTo &apos;Peptidase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Folate Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Folic Acid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GGH Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103926</classIRI>
<classLabel>Arachidonate 12-Lipoxygenase, 12S-Type</classLabel>
<deletedAxiom>&apos;Arachidonate 12-Lipoxygenase, 12S-Type&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Sarcolemma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxygenase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Leukotriene Production&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALOX12 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Arachidonate 12-Lipoxygenase, 12S-Type&apos; EquivalentTo &apos;Oxygenase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Sarcolemma&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Leukotriene Production&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALOX12 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103929</classIRI>
<classLabel>Arginase-1</classLabel>
<deletedAxiom>&apos;Arginase-1&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biogenic Amine Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Catabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ARG1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Arginase-1&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arginine and Proline Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biogenic Amine Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Catabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ARG1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103910</classIRI>
<classLabel>Putative Neutral Ceramidase C</classLabel>
<deletedAxiom>&apos;Putative Neutral Ceramidase C&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Hydrolase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103996</classIRI>
<classLabel>S-Methyl-5&apos;-Thioadenosine Phosphorylase</classLabel>
<deletedAxiom>&apos;S-Methyl-5&apos;-Thioadenosine Phosphorylase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Glycosyltransferase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Amino Acid Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MTAP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;S-Methyl-5&apos;-Thioadenosine Phosphorylase&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cysteine and Methionine Metabolism Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytosol&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Amino Acid Biosynthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MTAP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29586</classIRI>
<classLabel>Tyrosine-Protein Kinase FRK</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase FRK&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FRK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase FRK&apos; EquivalentTo &apos;SRC Family Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH2 Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SH3 Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FRK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29591</classIRI>
<classLabel>3-Ketodihydrosphingosine Reductase</classLabel>
<deletedAxiom>&apos;3-Ketodihydrosphingosine Reductase&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29568</classIRI>
<classLabel>Dual Specificity Protein Phosphatase 1</classLabel>
<deletedAxiom>&apos;Dual Specificity Protein Phosphatase 1&apos; EquivalentTo &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of p38-alpha and p38-beta Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Dual-Specificity Phosphoprotein Phosphatase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DUSP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dual Specificity Protein Phosphatase 1&apos; EquivalentTo &apos;Dual-Specificity Phosphoprotein Phosphatase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CD40L Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAP Kinase Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Activation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TNFR2 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;ATF-2 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Epidermal Growth Factor Receptor Downstream Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fc-Epsilon Receptor I Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Regulation of p38-alpha and p38-beta Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Inhibition of Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DUSP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29569</classIRI>
<classLabel>Disks Large Homolog 1</classLabel>
<deletedAxiom>&apos;Disks Large Homolog 1&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Junction Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Cell Shape&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DLG1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Disks Large Homolog 1&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Junction Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Cell Shape&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DLG1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29570</classIRI>
<classLabel>Disks Large Homolog 4</classLabel>
<deletedAxiom>&apos;Disks Large Homolog 4&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Junction Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Regulatory Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DLG4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Disks Large Homolog 4&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nitric Oxide Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Synaptic Junction Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DLG4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29620</classIRI>
<classLabel>Geminin</classLabel>
<deletedAxiom>&apos;Geminin&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GMNN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Geminin&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Negative Regulation of Cell Cycle&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Replication Inhibition&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GMNN Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C123150</classIRI>
<classLabel>Extracellular Superoxide Dismutase [Cu-Zn]</classLabel>
<deletedAxiom>&apos;Extracellular Superoxide Dismutase [Cu-Zn]&apos; EquivalentTo &apos;Superoxide Dismutase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Oxidoreductase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SOD3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Extracellular Superoxide Dismutase [Cu-Zn]&apos; EquivalentTo &apos;Superoxide Dismutase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Detoxification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidative Stress&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SOD3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C46001</classIRI>
<classLabel>Cytochrome P450 2C8</classLabel>
<deletedAxiom>&apos;Cytochrome P450 2C8&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2C8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 2C8&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Arachidonic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP2C8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C46000</classIRI>
<classLabel>Cytochrome P450 3A7</classLabel>
<deletedAxiom>&apos;Cytochrome P450 3A7&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytochrome P450&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP3A7 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Cytochrome P450 3A7&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Steroid Hormone Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fatty Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Retinol Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Linoleic Acid Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Metabolism of Xenobiotics by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Cytochrome P450 Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Drug Metabolism by Non-CYP450 Enzymes Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Steroid Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Xenobiotic Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP3A7 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29762</classIRI>
<classLabel>RAN GTPase Activating Protein 1</classLabel>
<deletedAxiom>&apos;RAN GTPase Activating Protein 1&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Import into Nucleus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitotic Spindle Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ran Cycling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;GTPase-Activating Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleocytoplasmic Transport&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RANGAP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAN GTPase Activating Protein 1&apos; EquivalentTo &apos;GTPase-Activating Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Protein Import into Nucleus Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sumoylation Regulation of Transcriptional Repression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Mitotic Spindle Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ran Cycling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleocytoplasmic Transport&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RANGAP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29748</classIRI>
<classLabel>Interleukin-1 Receptor-Associated Kinase 1</classLabel>
<deletedAxiom>&apos;Interleukin-1 Receptor-Associated Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IRAK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Interleukin-1 Receptor-Associated Kinase 1&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NFKB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leishmaniasis Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chagas Disease Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IRAK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29753</classIRI>
<classLabel>Tyrosine-Protein Kinase ITK/TSK</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase ITK/TSK&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Co-Stimulatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Host Defense Mechanism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ITK Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase ITK/TSK&apos; EquivalentTo &apos;Protein Tyrosine Kinase&apos; and &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Activation Co-Stimulatory Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T Cell Receptor Signaling Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Host Defense Mechanism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ITK Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29754</classIRI>
<classLabel>Inositol 1,4,5-Trisphosphate Receptor Type 1</classLabel>
<deletedAxiom>&apos;Inositol 1,4,5-Trisphosphate Receptor Type 1&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transport Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ITPR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Inositol 1,4,5-Trisphosphate Receptor Type 1&apos; EquivalentTo &apos;Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phosphatidylinositol Signaling System Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Calcium-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Depression Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Oocyte Meiosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gap Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gonadotropin-Releasing Hormone Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Vascular Smooth Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salivary Secretion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Gastric Acid Secretion Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transport Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ITPR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29831</classIRI>
<classLabel>Retinoblastoma-Like Protein 2</classLabel>
<deletedAxiom>&apos;Retinoblastoma-Like Protein 2&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell to Cell Adhesion Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Cycle Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Repressor/Corepressor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RBL2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Retinoblastoma-Like Protein 2&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and &apos;Transcription Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cell to Cell Adhesion Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;CXCR4 Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Macrophage Differentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pyk2 and Map Kinase Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Repressor/Corepressor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Repression&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RBL2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29880</classIRI>
<classLabel>Tyrosine-Protein Kinase Transmembrane Receptor ROR2</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Transmembrane Receptor ROR2&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Kringle Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Frizzled Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Migration Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ROR2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Transmembrane Receptor ROR2&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Noncanonical Wnt Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Kringle Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Frizzled Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Proliferation Regulatory Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Migration Induction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ROR2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29881</classIRI>
<classLabel>Nuclear Receptor ROR-Alpha</classLabel>
<deletedAxiom>&apos;Nuclear Receptor ROR-Alpha&apos; EquivalentTo &apos;Nuclear Orphan Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Circadian Rhythm Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Factor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Organogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RORA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Nuclear Receptor ROR-Alpha&apos; EquivalentTo &apos;Nuclear Orphan Receptor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Circadian Rhythm Pathway KEGG&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HIF-1-Alpha Transcription Factor Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Nuclear Hormone Receptor Superfamily&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Organogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RORA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29868</classIRI>
<classLabel>Rhodopsin Kinase</classLabel>
<deletedAxiom>&apos;Rhodopsin Kinase&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Protein Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRK1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Rhodopsin Kinase&apos; EquivalentTo &apos;G Protein-Coupled Receptor Kinase&apos; and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phosphorylation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;GRK1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29872</classIRI>
<classLabel>Receptor-Interacting Serine/Threonine-Protein Kinase 2</classLabel>
<deletedAxiom>&apos;Receptor-Interacting Serine/Threonine-Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RIPK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Interacting Serine/Threonine-Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Fas Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NOD-Like Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Canonical NF-kappaB Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL12-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nerve Growth Factor Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Shigellosis Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RIPK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29873</classIRI>
<classLabel>Receptor-Interacting Serine/Threonine-Protein Kinase 3</classLabel>
<deletedAxiom>&apos;Receptor-Interacting Serine/Threonine-Protein Kinase 3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytosolic DNA-Sensing Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine/Threonine Protein Kinase&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RIPK3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Receptor-Interacting Serine/Threonine-Protein Kinase 3&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cytosolic DNA-Sensing Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RIPK3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29879</classIRI>
<classLabel>Tyrosine-Protein Kinase Transmembrane Receptor ROR1</classLabel>
<deletedAxiom>&apos;Tyrosine-Protein Kinase Transmembrane Receptor ROR1&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Kringle Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Frizzled Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Receptor Tyrosine Kinase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ROR1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tyrosine-Protein Kinase Transmembrane Receptor ROR1&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Kringle Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin-Like C2-Type Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Frizzled Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ROR1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29876</classIRI>
<classLabel>Ribonuclease 3</classLabel>
<deletedAxiom>&apos;Ribonuclease 3&apos; EquivalentTo &apos;Endoribonuclease&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;RNase III Family Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Double-Stranded RNA Binding Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ribonuclease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Interference&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;MicroRNA Synthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNASEN Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ribonuclease 3&apos; EquivalentTo &apos;Endoribonuclease&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;RNase III Family Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Double-Stranded RNA Binding Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Degradation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Interference&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;MicroRNA Synthesis&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RNASEN Gene&apos;)</newAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125571</classIRI>
<classLabel>Slightly Agree</classLabel>
<newAxiom>'Slightly Agree' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125570</classIRI>
<classLabel>Slightly Disagree</classLabel>
<newAxiom>'Slightly Disagree' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125575</classIRI>
<classLabel>MORC2 Gene</classLabel>
<newAxiom>'MORC2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Lipid Metabolic Process'</newAxiom>
<newAxiom>'MORC2 Gene' SubClassOf 'Ligand Binding Protein Gene'</newAxiom>
<newAxiom>'MORC2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Repression'</newAxiom>
<newAxiom>'MORC2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Metal Ion Binding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125574</classIRI>
<classLabel>Unconventional Myosin-XV</classLabel>
<newAxiom>'Unconventional Myosin-XV' EquivalentTo 'Cytoskeletal Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoskeleton') and ('Gene_Product_Has_Associated_Anatomy' some 'Stereocilium') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'SH3 Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Actin-Binding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Hearing') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Regulation of Cell Shape') and ('Gene_Product_Encoded_By_Gene' some 'MYO15A Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125573</classIRI>
<classLabel>MYO15A wt Allele</classLabel>
<newAxiom>'MYO15A wt Allele' SubClassOf 'MYO15A Gene'</newAxiom>
<newAxiom>'MYO15A wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '17p11.2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125572</classIRI>
<classLabel>MYO15A Gene</classLabel>
<newAxiom>'MYO15A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Hearing'</newAxiom>
<newAxiom>'MYO15A Gene' SubClassOf 'Cytoskeletal Gene'</newAxiom>
<newAxiom>'MYO15A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Regulation of Cell Shape'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125567</classIRI>
<classLabel>Not Afraid of Trying a Medical Test or Treatment Even If Experts Had Conflicting Opinions</classLabel>
<newAxiom>'Not Afraid of Trying a Medical Test or Treatment Even If Experts Had Conflicting Opinions' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125568</classIRI>
<classLabel>Willing to Try Medical Test or Treatment if Experts Had Conflicting Opinions</classLabel>
<newAxiom>'Willing to Try Medical Test or Treatment if Experts Had Conflicting Opinions' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125565</classIRI>
<classLabel>Would Not Have Confidence in a Medical Test or Treatment if Experts Had Conflicting Opinions</classLabel>
<newAxiom>'Would Not Have Confidence in a Medical Test or Treatment if Experts Had Conflicting Opinions' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125566</classIRI>
<classLabel>Conflicting Expert Opinions About a Medical Test or Treatment Would Make Me Upset</classLabel>
<newAxiom>'Conflicting Expert Opinions About a Medical Test or Treatment Would Make Me Upset' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125569</classIRI>
<classLabel>Would Avoid Making Decisions About A Medical Test or Treatment if Experts Had Conflicting Opinions</classLabel>
<newAxiom>'Would Avoid Making Decisions About A Medical Test or Treatment if Experts Had Conflicting Opinions' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125560</classIRI>
<classLabel>Made Final Selection About Which Treatment I Will Receive</classLabel>
<newAxiom>'Made Final Selection About Which Treatment I Will Receive' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125562</classIRI>
<classLabel>Doctor and I Shared Responsibility for Deciding Which Treatment is Best for Me</classLabel>
<newAxiom>'Doctor and I Shared Responsibility for Deciding Which Treatment is Best for Me' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125561</classIRI>
<classLabel>Made Final Selection of My Treatment After Seriously Considering Doctor's Opinion</classLabel>
<newAxiom>'Made Final Selection of My Treatment After Seriously Considering Doctor's Opinion' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125564</classIRI>
<classLabel>Conflicting Expert Opinions About a Medical Test or Treatment Would Lower My Trust in the Experts</classLabel>
<newAxiom>'Conflicting Expert Opinions About a Medical Test or Treatment Would Lower My Trust in the Experts' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125563</classIRI>
<classLabel>Doctor Made Final Decision About Which Treatment Will Be Used but Seriously Considered My Opinion</classLabel>
<newAxiom>'Doctor Made Final Decision About Which Treatment Will Be Used but Seriously Considered My Opinion' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125554</classIRI>
<classLabel>Prefer to Make Final Selection About Which Treatment I Will Receive</classLabel>
<newAxiom>'Prefer to Make Final Selection About Which Treatment I Will Receive' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125555</classIRI>
<classLabel>Prefer to Make Final Selection of My Treatment After Seriously Considering My Doctor's Opinion</classLabel>
<newAxiom>'Prefer to Make Final Selection of My Treatment After Seriously Considering My Doctor's Opinion' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125556</classIRI>
<classLabel>Prefer My Doctor and I Share Responsibility for Deciding Which Treatment is Best</classLabel>
<newAxiom>'Prefer My Doctor and I Share Responsibility for Deciding Which Treatment is Best' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125557</classIRI>
<classLabel>Prefer My Doctor Makes Final Decision About Which Treatment is Used but Seriously Considers My Opinion</classLabel>
<newAxiom>'Prefer My Doctor Makes Final Decision About Which Treatment is Used but Seriously Considers My Opinion' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125558</classIRI>
<classLabel>Prefer to Leave All Decisions Regarding Treatment to My Doctor</classLabel>
<newAxiom>'Prefer to Leave All Decisions Regarding Treatment to My Doctor' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125559</classIRI>
<classLabel>You and Your Doctor's Cancer Treatment Decision</classLabel>
<newAxiom>'You and Your Doctor's Cancer Treatment Decision' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125553</classIRI>
<classLabel>Developmentally-Regulated GTP-Binding Protein 2</classLabel>
<newAxiom>'Developmentally-Regulated GTP-Binding Protein 2' EquivalentTo 'Ligand Binding Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'GTP Binding Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cell Differentiation Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cell Proliferation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'GTP Binding') and ('Gene_Product_Encoded_By_Gene' some 'DRG2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125552</classIRI>
<classLabel>DRG2 wt Allele</classLabel>
<newAxiom>'DRG2 wt Allele' SubClassOf 'DRG2 Gene'</newAxiom>
<newAxiom>'DRG2 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '17p11.2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125551</classIRI>
<classLabel>DRG2 Gene</classLabel>
<newAxiom>'DRG2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cell Differentiation Process'</newAxiom>
<newAxiom>'DRG2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'DRG2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cell Proliferation'</newAxiom>
<newAxiom>'DRG2 Gene' SubClassOf 'Ligand Binding Protein Gene'</newAxiom>
<newAxiom>'DRG2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'GTP Binding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125550</classIRI>
<classLabel>Preference for Decision About Choosing a Treatment</classLabel>
<newAxiom>'Preference for Decision About Choosing a Treatment' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125549</classIRI>
<classLabel>Antibody-drug Conjugate ADCT-402</classLabel>
<newAxiom>'Antibody-drug Conjugate ADCT-402' SubClassOf 'Immunoconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125547</classIRI>
<classLabel>Importance Rating Score 4</classLabel>
<newAxiom>'Importance Rating Score 4' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125548</classIRI>
<classLabel>Emactuzumab</classLabel>
<newAxiom>'Emactuzumab' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125545</classIRI>
<classLabel>Importance Rating Score 2</classLabel>
<newAxiom>'Importance Rating Score 2' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125546</classIRI>
<classLabel>Importance Rating Score 3</classLabel>
<newAxiom>'Importance Rating Score 3' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125543</classIRI>
<classLabel>Importance Rating Score 0</classLabel>
<newAxiom>'Importance Rating Score 0' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125544</classIRI>
<classLabel>Importance Rating Score 1</classLabel>
<newAxiom>'Importance Rating Score 1' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125540</classIRI>
<classLabel>How Important Standard Treatment Improves Quality of Life</classLabel>
<newAxiom>'How Important Standard Treatment Improves Quality of Life' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125542</classIRI>
<classLabel>Importance Rating Likert Scale</classLabel>
<newAxiom>'Importance Rating Likert Scale' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125541</classIRI>
<classLabel>Overall Value Treatment Based on Tumor Molecular Profile</classLabel>
<newAxiom>'Overall Value Treatment Based on Tumor Molecular Profile' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125536</classIRI>
<classLabel>26S Proteasome Non-ATPase Regulatory Subunit 11</classLabel>
<newAxiom>'26S Proteasome Non-ATPase Regulatory Subunit 11' EquivalentTo 'Regulatory Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'RAR and RXR Degradation Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Proteasome Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Embryonic Stem Cell') and ('Gene_Product_Has_Associated_Anatomy' some 'PA700 Regulatory Module') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Protein-Protein Interaction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Ubiquitinated Protein Degradation') and ('Gene_Product_Encoded_By_Gene' some 'PSMD11 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125537</classIRI>
<classLabel>How Important Standard Treatment Extends Survival</classLabel>
<newAxiom>'How Important Standard Treatment Extends Survival' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125538</classIRI>
<classLabel>How Important Standard Treatment Improves Symptoms</classLabel>
<newAxiom>'How Important Standard Treatment Improves Symptoms' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125539</classIRI>
<classLabel>How Important Standard Treatment Avoids Side Effects from Treatment</classLabel>
<newAxiom>'How Important Standard Treatment Avoids Side Effects from Treatment' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125532</classIRI>
<classLabel>How Important Treatment Based on Tumor Molecular Profile Avoids Side Effects from Treatment</classLabel>
<newAxiom>'How Important Treatment Based on Tumor Molecular Profile Avoids Side Effects from Treatment' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125533</classIRI>
<classLabel>PSMD11 Gene</classLabel>
<newAxiom>'PSMD11 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Protein-Protein Interaction'</newAxiom>
<newAxiom>'PSMD11 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Ubiquitinated Protein Degradation'</newAxiom>
<newAxiom>'PSMD11 Gene' SubClassOf 'Regulatory Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125534</classIRI>
<classLabel>How Important Treatment Based on Tumor Molecular Profile Improves Quality of Life</classLabel>
<newAxiom>'How Important Treatment Based on Tumor Molecular Profile Improves Quality of Life' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125535</classIRI>
<classLabel>PSMD11 wt Allele</classLabel>
<newAxiom>'PSMD11 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Proteasome Pathway'</newAxiom>
<newAxiom>'PSMD11 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '17q11.2'</newAxiom>
<newAxiom>'PSMD11 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'RAR and RXR Degradation Pathway'</newAxiom>
<newAxiom>'PSMD11 wt Allele' SubClassOf 'PSMD11 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125599</classIRI>
<classLabel>Weaver Syndrome</classLabel>
<newAxiom>'Weaver Syndrome' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
<newAxiom>'Weaver Syndrome' SubClassOf 'Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125598</classIRI>
<classLabel>Spondylocostal Dysostosis</classLabel>
<newAxiom>'Spondylocostal Dysostosis' SubClassOf 'Dysostosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125596</classIRI>
<classLabel>Neuraminidase Deficiency</classLabel>
<newAxiom>'Neuraminidase Deficiency' SubClassOf 'Mucolipidosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125597</classIRI>
<classLabel>Polysyndactyly</classLabel>
<newAxiom>'Polysyndactyly' SubClassOf 'Metabolic Disorder'</newAxiom>
<newAxiom>'Polysyndactyly' SubClassOf 'Congenital Abnormality'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125594</classIRI>
<classLabel>Kniest Dysplasia</classLabel>
<newAxiom>'Kniest Dysplasia' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125595</classIRI>
<classLabel>Mucolipidosis Type IIIA</classLabel>
<newAxiom>'Mucolipidosis Type IIIA' SubClassOf 'Mucolipidosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125592</classIRI>
<classLabel>Holt-Oram Syndrome</classLabel>
<newAxiom>'Holt-Oram Syndrome' SubClassOf 'Syndrome'</newAxiom>
<newAxiom>'Holt-Oram Syndrome' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125593</classIRI>
<classLabel>Hyperpipecolatemia</classLabel>
<newAxiom>'Hyperpipecolatemia' SubClassOf 'Metabolic Disorder'</newAxiom>
<newAxiom>'Hyperpipecolatemia' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125590</classIRI>
<classLabel>Casein Kinase I Isoform Delta</classLabel>
<newAxiom>'Casein Kinase I Isoform Delta' EquivalentTo 'Serine/Threonine Protein Kinase' and ('Gene_Product_Is_Element_In_Pathway' some 'Circadian Rhythm Pathway KEGG') and ('Gene_Product_Is_Element_In_Pathway' some 'CK1/CDK5 Regulation Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Gap Junction Assembly Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Hedgehog Signaling Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Microtubule') and ('Gene_Product_Has_Associated_Anatomy' some 'Centrosome') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'DNA Repair') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Mitosis') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Serine/Threonine Phosphorylation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Regulation of Cell Shape') and ('Gene_Product_Encoded_By_Gene' some 'CSNK1D Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125591</classIRI>
<classLabel>Dubowitz Syndrome</classLabel>
<newAxiom>'Dubowitz Syndrome' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
<newAxiom>'Dubowitz Syndrome' SubClassOf 'Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125589</classIRI>
<classLabel>CSNK1D wt Allele</classLabel>
<newAxiom>'CSNK1D wt Allele' EquivalentTo 'CSNK1D Gene' and ('Gene_Is_Element_In_Pathway' some 'Circadian Rhythm Pathway KEGG') and ('Gene_Is_Element_In_Pathway' some 'CK1/CDK5 Regulation Pathway') and ('Gene_Is_Element_In_Pathway' some 'Gap Junction Assembly Pathway') and ('Gene_Is_Element_In_Pathway' some 'Hedgehog Signaling Pathway') and ('Gene_In_Chromosomal_Location' some '17q25')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125588</classIRI>
<classLabel>CSNK1D Gene</classLabel>
<newAxiom>'CSNK1D Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Serine/Threonine Phosphorylation'</newAxiom>
<newAxiom>'CSNK1D Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Mitosis'</newAxiom>
<newAxiom>'CSNK1D Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'CSNK1D Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'DNA Repair'</newAxiom>
<newAxiom>'CSNK1D Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
<newAxiom>'CSNK1D Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Regulation of Cell Shape'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125587</classIRI>
<classLabel>Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A</classLabel>
<newAxiom>'Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member A' EquivalentTo 'Regulatory Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'Granzyme A Mediated Apoptosis Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleus') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Leucine-Rich Repeat') and ('Gene_Product_Has_Biochemical_Function' some 'Tumor Suppressor Protein') and ('Gene_Product_Has_Biochemical_Function' some 'RNA Binding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'RNA Transport') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Regulation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'RNA Binding') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Tumor Suppression') and ('Gene_Product_Encoded_By_Gene' some 'ANP32A Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125583</classIRI>
<classLabel>SCRIB wt Allele</classLabel>
<newAxiom>'SCRIB wt Allele' SubClassOf 'SCRIB Gene'</newAxiom>
<newAxiom>'SCRIB wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '8q24.3'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125584</classIRI>
<classLabel>Protein Scribble Homolog</classLabel>
<newAxiom>'Protein Scribble Homolog' EquivalentTo 'Structural Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Cell Junction') and ('Gene_Product_Has_Associated_Anatomy' some 'Cellular Membrane') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Leucine-Rich Repeat') and ('Gene_Product_Has_Biochemical_Function' some 'Scaffolding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Apoptosis') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cell Proliferation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Regulation of Cell Shape') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cellular Migration Process') and ('Gene_Product_Encoded_By_Gene' some 'SCRIB Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125585</classIRI>
<classLabel>ANP32A Gene</classLabel>
<newAxiom>'ANP32A Gene' SubClassOf 'Regulatory Gene'</newAxiom>
<newAxiom>'ANP32A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Tumor Suppression'</newAxiom>
<newAxiom>'ANP32A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Regulation'</newAxiom>
<newAxiom>'ANP32A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'RNA Binding'</newAxiom>
<newAxiom>'ANP32A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'ANP32A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'RNA Transport'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125586</classIRI>
<classLabel>ANP32A wt Allele</classLabel>
<newAxiom>'ANP32A wt Allele' SubClassOf 'ANP32A Gene'</newAxiom>
<newAxiom>'ANP32A wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '15q23'</newAxiom>
<newAxiom>'ANP32A wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Granzyme A Mediated Apoptosis Pathway'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125580</classIRI>
<classLabel>Oxysterol-Binding Protein 2</classLabel>
<newAxiom>'Oxysterol-Binding Protein 2' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Lipid Binding'</newAxiom>
<newAxiom>'Oxysterol-Binding Protein 2' SubClassOf 'Ligand Binding Protein'</newAxiom>
<newAxiom>'Oxysterol-Binding Protein 2' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'OSBP2 Gene'</newAxiom>
<newAxiom>'Oxysterol-Binding Protein 2' SubClassOf 'Gene_Product_Has_Structural_Domain_Or_Motif' some 'PH Domain'</newAxiom>
<newAxiom>'Oxysterol-Binding Protein 2' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Cellular Membrane'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125581</classIRI>
<classLabel>Pathology Result</classLabel>
<newAxiom>'Pathology Result' SubClassOf 'Clinical Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125582</classIRI>
<classLabel>SCRIB Gene</classLabel>
<newAxiom>'SCRIB Gene' SubClassOf 'Structural Protein Gene'</newAxiom>
<newAxiom>'SCRIB Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Regulation of Cell Shape'</newAxiom>
<newAxiom>'SCRIB Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Apoptosis'</newAxiom>
<newAxiom>'SCRIB Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cellular Migration Process'</newAxiom>
<newAxiom>'SCRIB Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cell Proliferation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125577</classIRI>
<classLabel>MORC Family CW-Type Zinc Finger Protein 2</classLabel>
<newAxiom>'MORC Family CW-Type Zinc Finger Protein 2' EquivalentTo 'Ligand Binding Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleus') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Expressed_In_Tissue' some 'Pancreas') and ('Gene_Product_Expressed_In_Tissue' some 'Smooth Muscle Tissue') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Metal Binding Site') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Repression') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Lipid Metabolic Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Metal Ion Binding') and ('Gene_Product_Encoded_By_Gene' some 'MORC2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125576</classIRI>
<classLabel>MORC2 wt Allele</classLabel>
<newAxiom>'MORC2 wt Allele' SubClassOf 'MORC2 Gene'</newAxiom>
<newAxiom>'MORC2 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '22q12.2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125579</classIRI>
<classLabel>OSBP2 wt Allele</classLabel>
<newAxiom>'OSBP2 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '22q12.2'</newAxiom>
<newAxiom>'OSBP2 wt Allele' SubClassOf 'OSBP2 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125578</classIRI>
<classLabel>OSBP2 Gene</classLabel>
<newAxiom>'OSBP2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Lipid Binding'</newAxiom>
<newAxiom>'OSBP2 Gene' SubClassOf 'Ligand Binding Protein Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125602</classIRI>
<classLabel>Left All Decisions Regarding My Treatment to My Doctor</classLabel>
<newAxiom>'Left All Decisions Regarding My Treatment to My Doctor' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125603</classIRI>
<classLabel>Bcl-2 Inhibitor BCL201</classLabel>
<newAxiom>'Bcl-2 Inhibitor BCL201' SubClassOf 'Antineoplastic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125604</classIRI>
<classLabel>Conjugated Estrogens/Bazedoxifene</classLabel>
<newAxiom>'Conjugated Estrogens/Bazedoxifene' SubClassOf 'Hormone Replacement Preparation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125605</classIRI>
<classLabel>EGFR Exon 20 Insertion Mutation</classLabel>
<newAxiom>'EGFR Exon 20 Insertion Mutation' SubClassOf 'EGFR Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125600</classIRI>
<classLabel>Off-Label Treatment</classLabel>
<newAxiom>'Off-Label Treatment' SubClassOf 'Other Intervention or Procedure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125601</classIRI>
<classLabel>Carboplatin/Etoposide/Melphalan Regimen</classLabel>
<newAxiom>'Carboplatin/Etoposide/Melphalan Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Prednisone'</newAxiom>
<newAxiom>'Carboplatin/Etoposide/Melphalan Regimen' SubClassOf 'Chemotherapy Regimen Used to Treat Non-Hodgkin Lymphoma'</newAxiom>
<newAxiom>'Carboplatin/Etoposide/Melphalan Regimen' SubClassOf 'Regimen_Has_Accepted_Use_For_Disease' some 'Chronic Lymphocytic Leukemia'</newAxiom>
<newAxiom>'Carboplatin/Etoposide/Melphalan Regimen' SubClassOf 'Regimen_Has_Accepted_Use_For_Disease' some 'Indolent Adult Non-Hodgkin Lymphoma'</newAxiom>
<newAxiom>'Carboplatin/Etoposide/Melphalan Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine'</newAxiom>
<newAxiom>'Carboplatin/Etoposide/Melphalan Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125606</classIRI>
<classLabel>BRAT Diet</classLabel>
<newAxiom>'BRAT Diet' SubClassOf 'Diet'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125607</classIRI>
<classLabel>P-cadherin-targeting Agent PF-06671008</classLabel>
<newAxiom>'P-cadherin-targeting Agent PF-06671008' SubClassOf 'Antineoplastic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125608</classIRI>
<classLabel>Begelomab</classLabel>
<newAxiom>'Begelomab' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125609</classIRI>
<classLabel>4D PET Scan</classLabel>
<newAxiom>'4D PET Scan' SubClassOf '4-Dimensional Computed Tomography'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125639</classIRI>
<classLabel>Enterovirus D68</classLabel>
<newAxiom>'Enterovirus D68' SubClassOf 'Enterovirus'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125638</classIRI>
<classLabel>Chikungunya Virus</classLabel>
<newAxiom>'Chikungunya Virus' SubClassOf 'Alphavirus'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125637</classIRI>
<classLabel>Mucorales</classLabel>
<newAxiom>'Mucorales' SubClassOf 'Fungus'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125636</classIRI>
<classLabel>Mycobacterium mucogenicum</classLabel>
<newAxiom>'Mycobacterium mucogenicum' SubClassOf 'Mycobacterium'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125635</classIRI>
<classLabel>Breast Cancer Prevention Trial Symptom Scales</classLabel>
<newAxiom>'Breast Cancer Prevention Trial Symptom Scales' SubClassOf 'Clinical or Research Assessment Questionnaire'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125634</classIRI>
<classLabel>Dendritic Cell-Precision Multiple Antigen T-Lymphocytes</classLabel>
<newAxiom>'Dendritic Cell-Precision Multiple Antigen T-Lymphocytes' SubClassOf 'Biological Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125633</classIRI>
<classLabel>Anti-Epidermal Growth Factor Receptor 2 Antibody Expressing Pluripotent Killer T-Lymphocytes</classLabel>
<newAxiom>'Anti-Epidermal Growth Factor Receptor 2 Antibody Expressing Pluripotent Killer T-Lymphocytes' SubClassOf 'Biological Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125632</classIRI>
<classLabel>Shi Pi Yin Herbal Decoction</classLabel>
<newAxiom>'Shi Pi Yin Herbal Decoction' SubClassOf 'Diuretic'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125631</classIRI>
<classLabel>Live-attenuated Double-deleted Listeria monocytogenes Bacteria JNJ-64041809</classLabel>
<newAxiom>'Live-attenuated Double-deleted Listeria monocytogenes Bacteria JNJ-64041809' SubClassOf 'Attenuated Bacteria Vaccine'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125640</classIRI>
<classLabel>Human Metapneumovirus</classLabel>
<newAxiom>'Human Metapneumovirus' SubClassOf 'Pneumovirinae'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125641</classIRI>
<classLabel>Human Parainfluenza Virus</classLabel>
<newAxiom>'Human Parainfluenza Virus' SubClassOf 'Parainfluenza Virus'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125647</classIRI>
<classLabel>Bothered by Vomiting</classLabel>
<newAxiom>'Bothered by Vomiting' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125646</classIRI>
<classLabel>Bothered by Nausea</classLabel>
<newAxiom>'Bothered by Nausea' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125649</classIRI>
<classLabel>Bothered by Difficulty with Bladder Control at Other Times</classLabel>
<newAxiom>'Bothered by Difficulty with Bladder Control at Other Times' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125648</classIRI>
<classLabel>Bothered by Difficulty with Bladder Control when Laughing or Crying</classLabel>
<newAxiom>'Bothered by Difficulty with Bladder Control when Laughing or Crying' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125643</classIRI>
<classLabel>Strongyloides stercoralis</classLabel>
<newAxiom>'Strongyloides stercoralis' SubClassOf 'Nematoda'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125642</classIRI>
<classLabel>Helminth</classLabel>
<newAxiom>'Helminth' SubClassOf 'Other Organism Groupings'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125645</classIRI>
<classLabel>Bothered by Hot Flashes</classLabel>
<newAxiom>'Bothered by Hot Flashes' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125644</classIRI>
<classLabel>Toxoplasma gondii</classLabel>
<newAxiom>'Toxoplasma gondii' SubClassOf 'Toxoplasma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125650</classIRI>
<classLabel>Bothered by Vaginal Dryness</classLabel>
<newAxiom>'Bothered by Vaginal Dryness' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125652</classIRI>
<classLabel>Liposomal Bupivacaine</classLabel>
<newAxiom>'Liposomal Bupivacaine' SubClassOf 'Anesthetic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125619</classIRI>
<classLabel>Pain Interference Subordinate Domain</classLabel>
<newAxiom>'Pain Interference Subordinate Domain' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125618</classIRI>
<classLabel>Sleep Disturbance Subordinate Domain</classLabel>
<newAxiom>'Sleep Disturbance Subordinate Domain' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125617</classIRI>
<classLabel>Depression Subordinate Domain</classLabel>
<newAxiom>'Depression Subordinate Domain' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125612</classIRI>
<classLabel>Formalin-Fixed Paraffin-Embedded B-Cell (CD20) Digital Image</classLabel>
<newAxiom>'Formalin-Fixed Paraffin-Embedded B-Cell (CD20) Digital Image' SubClassOf 'Medical Image'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125611</classIRI>
<classLabel>Formalin-Fixed Paraffin-Embedded T-Cell (CD3) Slide</classLabel>
<newAxiom>'Formalin-Fixed Paraffin-Embedded T-Cell (CD3) Slide' SubClassOf 'Biospecimen'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125610</classIRI>
<classLabel>Formalin-Fixed Paraffin-Embedded B-Cell (CD20) Slide</classLabel>
<newAxiom>'Formalin-Fixed Paraffin-Embedded B-Cell (CD20) Slide' SubClassOf 'Biospecimen'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125616</classIRI>
<classLabel>Histological Subtype Different, Pathology Review for this Project</classLabel>
<newAxiom>'Histological Subtype Different, Pathology Review for this Project' SubClassOf 'Other Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125615</classIRI>
<classLabel>Histological Subtype Different, Other Pathology Review</classLabel>
<newAxiom>'Histological Subtype Different, Other Pathology Review' SubClassOf 'Other Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125614</classIRI>
<classLabel>Inconsistency Due to Macrodissection</classLabel>
<newAxiom>'Inconsistency Due to Macrodissection' SubClassOf 'Other Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125613</classIRI>
<classLabel>Formalin-Fixed Paraffin-Embedded T-Cell (CD3) Digital Image</classLabel>
<newAxiom>'Formalin-Fixed Paraffin-Embedded T-Cell (CD3) Digital Image' SubClassOf 'Medical Image'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125629</classIRI>
<classLabel>Moderately Worse</classLabel>
<newAxiom>'Moderately Worse' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125628</classIRI>
<classLabel>About the Same Response</classLabel>
<newAxiom>'About the Same Response' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125621</classIRI>
<classLabel>Global Rating of Change in Joint Pain and Stiffness Questionnaire</classLabel>
<newAxiom>'Global Rating of Change in Joint Pain and Stiffness Questionnaire' SubClassOf 'Clinical or Research Assessment Questionnaire'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125620</classIRI>
<classLabel>Anti-c-KIT Monoclonal Antibody KTN0158</classLabel>
<newAxiom>'Anti-c-KIT Monoclonal Antibody KTN0158' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125623</classIRI>
<classLabel>Level of Joint Pain</classLabel>
<newAxiom>'Level of Joint Pain' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125622</classIRI>
<classLabel>Change Since Last Time Questionnaire Filled Out</classLabel>
<newAxiom>'Change Since Last Time Questionnaire Filled Out' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125625</classIRI>
<classLabel>Level of Joint Stiffness</classLabel>
<newAxiom>'Level of Joint Stiffness' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125624</classIRI>
<classLabel>Carbon C 14 Anlotinib Hydrochloride</classLabel>
<newAxiom>'Carbon C 14 Anlotinib Hydrochloride' SubClassOf 'Radioconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125627</classIRI>
<classLabel>Moderately Better</classLabel>
<newAxiom>'Moderately Better' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125626</classIRI>
<classLabel>Very Much Better</classLabel>
<newAxiom>'Very Much Better' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125630</classIRI>
<classLabel>Very Much Worse</classLabel>
<newAxiom>'Very Much Worse' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125674</classIRI>
<classLabel>Bothered by Forgetfulness</classLabel>
<newAxiom>'Bothered by Forgetfulness' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125673</classIRI>
<classLabel>Bothered by Weight Gain</classLabel>
<newAxiom>'Bothered by Weight Gain' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125672</classIRI>
<classLabel>Bothered by Muscle Stiffness</classLabel>
<newAxiom>'Bothered by Muscle Stiffness' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125671</classIRI>
<classLabel>Bothered by Joint Pains</classLabel>
<newAxiom>'Bothered by Joint Pains' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125670</classIRI>
<classLabel>Bothered by General Aches and Pains</classLabel>
<newAxiom>'Bothered by General Aches and Pains' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125668</classIRI>
<classLabel>BCL2L1 Gene Product</classLabel>
<newAxiom>'BCL2L1 Gene Product' SubClassOf 'Apoptosis Regulator'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125669</classIRI>
<classLabel>Bothered by Pain with Intercourse</classLabel>
<newAxiom>'Bothered by Pain with Intercourse' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125666</classIRI>
<classLabel>MnSOD Mimetic BMX-001</classLabel>
<newAxiom>'MnSOD Mimetic BMX-001' SubClassOf 'Antioxidant'</newAxiom>
</newClass>
<newClass>
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<classLabel>Autologous Interferon-producing Killer Dendritic Cells</classLabel>
<newAxiom>'Autologous Interferon-producing Killer Dendritic Cells' SubClassOf 'Biological Agent'</newAxiom>
</newClass>
<newClass>
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<classLabel>Pain Agnosia</classLabel>
<newAxiom>'Pain Agnosia' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125665</classIRI>
<classLabel>X-Linked Creatine Transporter Deficiency</classLabel>
<newAxiom>'X-Linked Creatine Transporter Deficiency' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
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<classLabel>Carnosinemia</classLabel>
<newAxiom>'Carnosinemia' SubClassOf 'Metabolic Disorder'</newAxiom>
<newAxiom>'Carnosinemia' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
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<classLabel>Mouse Trisomy 16</classLabel>
<newAxiom>'Mouse Trisomy 16' SubClassOf 'Mouse Pathologic Diagnoses'</newAxiom>
</newClass>
<newClass>
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<classLabel>Combined Oxidative Phosphorylation Deficiency 1</classLabel>
<newAxiom>'Combined Oxidative Phosphorylation Deficiency 1' SubClassOf 'Metabolic Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125662</classIRI>
<classLabel>Carotid Artery Dissection</classLabel>
<newAxiom>'Carotid Artery Dissection' SubClassOf 'Carotid Artery Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125657</classIRI>
<classLabel>Ets-family Transcription Factor Inhibitor TK216</classLabel>
<newAxiom>'Ets-family Transcription Factor Inhibitor TK216' SubClassOf 'Antineoplastic Agent'</newAxiom>
</newClass>
<newClass>
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<classLabel>Fructooligosaccharide/Lactobacillus paracasei/Lactobacillus rhamnosus/Lactobacillus acidophilus/Bifidobacterium lactis Probiotic Supplement</classLabel>
<newAxiom>'Fructooligosaccharide/Lactobacillus paracasei/Lactobacillus rhamnosus/Lactobacillus acidophilus/Bifidobacterium lactis Probiotic Supplement' SubClassOf 'Dietary Supplement'</newAxiom>
</newClass>
<newClass>
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<classLabel>Adenosine-A2A Receptor Antagonist CPI-444</classLabel>
<newAxiom>'Adenosine-A2A Receptor Antagonist CPI-444' SubClassOf 'Immunostimulant'</newAxiom>
</newClass>
<newClass>
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<classLabel>Vortioxetine Hydrobromide</classLabel>
<newAxiom>'Vortioxetine Hydrobromide' SubClassOf 'Antidepressant Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125654</classIRI>
<classLabel>Anti-Programmed Cell Death Protein 1 Antibody Expressing Pluripotent Killer T-Lymphocytes</classLabel>
<newAxiom>'Anti-Programmed Cell Death Protein 1 Antibody Expressing Pluripotent Killer T-Lymphocytes' SubClassOf 'Biological Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125655</classIRI>
<classLabel>Smoked Plum</classLabel>
<newAxiom>'Smoked Plum' SubClassOf 'Fruit'</newAxiom>
</newClass>
<newClass>
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<classLabel>Methotrexate-Encapsulating Autologous Tumor-Derived Microparticles</classLabel>
<newAxiom>'Methotrexate-Encapsulating Autologous Tumor-Derived Microparticles' SubClassOf 'Folate Antagonist'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125692</classIRI>
<classLabel>Multipeptide Vaccine S-588210</classLabel>
<newAxiom>'Multipeptide Vaccine S-588210' SubClassOf 'Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue' some 'Cytotoxic T-Lymphocyte'</newAxiom>
<newAxiom>'Multipeptide Vaccine S-588210' SubClassOf 'Antineoplastic Vaccine'</newAxiom>
<newAxiom>'Multipeptide Vaccine S-588210' SubClassOf 'Peptide Vaccine'</newAxiom>
<newAxiom>'Multipeptide Vaccine S-588210' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'Immunopotentiation'</newAxiom>
<newAxiom>'Multipeptide Vaccine S-588210' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'T-Cell Activation'</newAxiom>
<newAxiom>'Multipeptide Vaccine S-588210' SubClassOf 'Chemical_Or_Drug_Has_Mechanism_Of_Action' some 'Antigen Sensitization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125691</classIRI>
<classLabel>Autologous Anti-CD19 CAR-expressing T Lymphocytes</classLabel>
<newAxiom>'Autologous Anti-CD19 CAR-expressing T Lymphocytes' SubClassOf 'Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue' some 'Cytotoxic T-Lymphocyte'</newAxiom>
<newAxiom>'Autologous Anti-CD19 CAR-expressing T Lymphocytes' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'T-Cell Activation'</newAxiom>
<newAxiom>'Autologous Anti-CD19 CAR-expressing T Lymphocytes' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
<newAxiom>'Autologous Anti-CD19 CAR-expressing T Lymphocytes' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'Immunopotentiation'</newAxiom>
<newAxiom>'Autologous Anti-CD19 CAR-expressing T Lymphocytes' SubClassOf 'Chemical_Or_Drug_Has_Mechanism_Of_Action' some 'Antigen Sensitization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125690</classIRI>
<classLabel>Antimetabolite FF-10502</classLabel>
<newAxiom>'Antimetabolite FF-10502' SubClassOf 'Antineoplastic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125696</classIRI>
<classLabel>Ehlers-Danlos Syndrome, Type I</classLabel>
<newAxiom>'Ehlers-Danlos Syndrome, Type I' SubClassOf 'Ehlers-Danlos Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125695</classIRI>
<classLabel>Striatonigral Degeneration</classLabel>
<newAxiom>'Striatonigral Degeneration' SubClassOf 'Central Nervous System Degenerative Disorder'</newAxiom>
<newAxiom>'Striatonigral Degeneration' SubClassOf 'Multiple System Atrophy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125694</classIRI>
<classLabel>Sitosterolemia</classLabel>
<newAxiom>'Sitosterolemia' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125693</classIRI>
<classLabel>Atransferrinemia</classLabel>
<newAxiom>'Atransferrinemia' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125688</classIRI>
<classLabel>Not at All Disrupted</classLabel>
<newAxiom>'Not at All Disrupted' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125689</classIRI>
<classLabel>PhenX</classLabel>
<newAxiom>'PhenX' SubClassOf 'Epidemiology Research'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125686</classIRI>
<classLabel>Somewhat Disrupted</classLabel>
<newAxiom>'Somewhat Disrupted' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125687</classIRI>
<classLabel>Totally Disrupted</classLabel>
<newAxiom>'Totally Disrupted' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125681</classIRI>
<classLabel>Extremely Agree</classLabel>
<newAxiom>'Extremely Agree' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125680</classIRI>
<classLabel>Bothered by Decreased Range of Motion in Arm on Surgery Side</classLabel>
<newAxiom>'Bothered by Decreased Range of Motion in Arm on Surgery Side' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125683</classIRI>
<classLabel>Somewhat Bothered</classLabel>
<newAxiom>'Somewhat Bothered' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125685</classIRI>
<classLabel>Quite a Bit Disrupted</classLabel>
<newAxiom>'Quite a Bit Disrupted' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125684</classIRI>
<classLabel>A Little Disrupted</classLabel>
<newAxiom>'A Little Disrupted' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125675</classIRI>
<classLabel>Bothered by the Appearance of My Body</classLabel>
<newAxiom>'Bothered by the Appearance of My Body' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125676</classIRI>
<classLabel>Bothered by Night Sweats</classLabel>
<newAxiom>'Bothered by Night Sweats' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125677</classIRI>
<classLabel>Bothered by Difficulty Concentrating</classLabel>
<newAxiom>'Bothered by Difficulty Concentrating' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125678</classIRI>
<classLabel>Bothered by Being Easily Distracted</classLabel>
<newAxiom>'Bothered by Being Easily Distracted' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125679</classIRI>
<classLabel>Bothered by Arm Swelling</classLabel>
<newAxiom>'Bothered by Arm Swelling' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125698</classIRI>
<classLabel>Ehlers-Danlos Syndrome, Type III</classLabel>
<newAxiom>'Ehlers-Danlos Syndrome, Type III' SubClassOf 'Ehlers-Danlos Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125697</classIRI>
<classLabel>Ehlers-Danlos Syndrome, Type II</classLabel>
<newAxiom>'Ehlers-Danlos Syndrome, Type II' SubClassOf 'Ehlers-Danlos Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125699</classIRI>
<classLabel>Ehlers-Danlos Syndrome, Type IV</classLabel>
<newAxiom>'Ehlers-Danlos Syndrome, Type IV' SubClassOf 'Ehlers-Danlos Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125705</classIRI>
<classLabel>Fanconi Anemia, Complementation Group D1</classLabel>
<newAxiom>'Fanconi Anemia, Complementation Group D1' SubClassOf 'Fanconi Anemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125706</classIRI>
<classLabel>Fanconi Anemia, Complementation Group D2</classLabel>
<newAxiom>'Fanconi Anemia, Complementation Group D2' SubClassOf 'Fanconi Anemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125707</classIRI>
<classLabel>Fanconi Anemia, Complementation Group F</classLabel>
<newAxiom>'Fanconi Anemia, Complementation Group F' SubClassOf 'Fanconi Anemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125708</classIRI>
<classLabel>Fanconi Anemia, Complementation Group G</classLabel>
<newAxiom>'Fanconi Anemia, Complementation Group G' SubClassOf 'Fanconi Anemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125709</classIRI>
<classLabel>Fanconi Anemia, Complementation Group E</classLabel>
<newAxiom>'Fanconi Anemia, Complementation Group E' SubClassOf 'Fanconi Anemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125700</classIRI>
<classLabel>Ehlers-Danlos Syndrome, Type VI</classLabel>
<newAxiom>'Ehlers-Danlos Syndrome, Type VI' SubClassOf 'Ehlers-Danlos Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125701</classIRI>
<classLabel>Ehlers-Danlos Syndrome, Type VII</classLabel>
<newAxiom>'Ehlers-Danlos Syndrome, Type VII' SubClassOf 'Ehlers-Danlos Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125702</classIRI>
<classLabel>Fanconi Anemia, Complementation Group A</classLabel>
<newAxiom>'Fanconi Anemia, Complementation Group A' SubClassOf 'Fanconi Anemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125703</classIRI>
<classLabel>Fanconi Anemia, Complementation Group B</classLabel>
<newAxiom>'Fanconi Anemia, Complementation Group B' SubClassOf 'Fanconi Anemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125704</classIRI>
<classLabel>Fanconi Anemia, Complementation Group C</classLabel>
<newAxiom>'Fanconi Anemia, Complementation Group C' SubClassOf 'Fanconi Anemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125718</classIRI>
<classLabel>SIRPa-Fc Fusion Protein TTI-621</classLabel>
<newAxiom>'SIRPa-Fc Fusion Protein TTI-621' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125716</classIRI>
<classLabel>Expiratory Muscle Strength Training</classLabel>
<newAxiom>'Expiratory Muscle Strength Training' SubClassOf 'Respiratory Therapy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125717</classIRI>
<classLabel>Anti-CD33 Antibody-drug Conjugate IMGN779</classLabel>
<newAxiom>'Anti-CD33 Antibody-drug Conjugate IMGN779' SubClassOf 'Immunoconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125714</classIRI>
<classLabel>Alvelestat</classLabel>
<newAxiom>'Alvelestat' SubClassOf 'Protease Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125715</classIRI>
<classLabel>Recurrent Acute Myeloid Leukemia with Myelodysplasia-Related Changes</classLabel>
<newAxiom>'Recurrent Acute Myeloid Leukemia with Myelodysplasia-Related Changes' EquivalentTo 'Recurrent Hematologic Malignancy' and 'Acute Myeloid Leukemia with Myelodysplasia-Related Changes'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125712</classIRI>
<classLabel>Immune Reconstitution Inflammatory Syndrome Associated with Kaposi Sarcoma</classLabel>
<newAxiom>'Immune Reconstitution Inflammatory Syndrome Associated with Kaposi Sarcoma' SubClassOf 'Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125710</classIRI>
<classLabel>Transfill</classLabel>
<newAxiom>'Transfill' SubClassOf 'Action'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125711</classIRI>
<classLabel>KSHV Inflammatory Cytokine Syndrome</classLabel>
<newAxiom>'KSHV Inflammatory Cytokine Syndrome' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
<newAxiom>'KSHV Inflammatory Cytokine Syndrome' SubClassOf 'Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125499</classIRI>
<classLabel>ID4 wt Allele</classLabel>
<newAxiom>'ID4 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '6p22.3'</newAxiom>
<newAxiom>'ID4 wt Allele' SubClassOf 'ID4 Gene'</newAxiom>
<newAxiom>'ID4 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'TGF-beta Signaling Pathway KEGG'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125469</classIRI>
<classLabel>TREM2 wt Allele</classLabel>
<newAxiom>'TREM2 wt Allele' SubClassOf 'TREM2 Gene'</newAxiom>
<newAxiom>'TREM2 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '6p21.1'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125468</classIRI>
<classLabel>TREM2 Gene</classLabel>
<newAxiom>'TREM2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Immune Response Process'</newAxiom>
<newAxiom>'TREM2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Lipid Binding'</newAxiom>
<newAxiom>'TREM2 Gene' SubClassOf 'Receptor Gene'</newAxiom>
<newAxiom>'TREM2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Inflammatory Response'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125467</classIRI>
<classLabel>Rho GTPase-Activating Protein 11B</classLabel>
<newAxiom>'Rho GTPase-Activating Protein 11B' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Cytosol'</newAxiom>
<newAxiom>'Rho GTPase-Activating Protein 11B' SubClassOf 'GTPase-Activating Protein'</newAxiom>
<newAxiom>'Rho GTPase-Activating Protein 11B' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'ARHGAP11B Gene'</newAxiom>
<newAxiom>'Rho GTPase-Activating Protein 11B' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'Rho GTPase-Activating Protein 11B' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Glial Cell'</newAxiom>
<newAxiom>'Rho GTPase-Activating Protein 11B' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Neural Development'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125466</classIRI>
<classLabel>ARHGAP11B wt Allele</classLabel>
<newAxiom>'ARHGAP11B wt Allele' SubClassOf 'ARHGAP11B Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125475</classIRI>
<classLabel>Ann Arbor Pathologic Stage II</classLabel>
<newAxiom>'Ann Arbor Pathologic Stage II' SubClassOf 'Ann Arbor Lymphoma Staging System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125476</classIRI>
<classLabel>Ann Arbor Clinical Stage III</classLabel>
<newAxiom>'Ann Arbor Clinical Stage III' SubClassOf 'Ann Arbor Lymphoma Staging System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125473</classIRI>
<classLabel>Ann Arbor Pathologic Stage I</classLabel>
<newAxiom>'Ann Arbor Pathologic Stage I' SubClassOf 'Ann Arbor Lymphoma Staging System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125474</classIRI>
<classLabel>Ann Arbor Clinical Stage II</classLabel>
<newAxiom>'Ann Arbor Clinical Stage II' SubClassOf 'Ann Arbor Lymphoma Staging System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125471</classIRI>
<classLabel>PI3K-gamma Inhibitor IPI-549</classLabel>
<newAxiom>'PI3K-gamma Inhibitor IPI-549' SubClassOf 'Protein Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125472</classIRI>
<classLabel>Ann Arbor Clinical Stage I</classLabel>
<newAxiom>'Ann Arbor Clinical Stage I' SubClassOf 'Ann Arbor Lymphoma Staging System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125470</classIRI>
<classLabel>Triggering Receptor Expressed On Myeloid Cells 2</classLabel>
<newAxiom>'Triggering Receptor Expressed On Myeloid Cells 2' EquivalentTo 'Receptor' and ('Gene_Product_Has_Associated_Anatomy' some 'Macrophage') and ('Gene_Product_Has_Associated_Anatomy' some 'Dendritic Cell') and ('Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Immunoglobulin-Like V-Type Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Cell Surface Receptor') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Immune Response Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Inflammatory Response') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Lipid Binding') and ('Gene_Product_Encoded_By_Gene' some 'TREM2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125459</classIRI>
<classLabel>Improved</classLabel>
<newAxiom>'Improved' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125456</classIRI>
<classLabel>Overall Experience Participating in Research Study</classLabel>
<newAxiom>'Overall Experience Participating in Research Study' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125455</classIRI>
<classLabel>Overall Quality of Life Change by Participating in Research Study</classLabel>
<newAxiom>'Overall Quality of Life Change by Participating in Research Study' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125458</classIRI>
<classLabel>Talk with Someone about Concerns</classLabel>
<newAxiom>'Talk with Someone about Concerns' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125457</classIRI>
<classLabel>One Thing to Improve Experience Participating in Research Study</classLabel>
<newAxiom>'One Thing to Improve Experience Participating in Research Study' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125462</classIRI>
<classLabel>GPR158 Gene</classLabel>
<newAxiom>'GPR158 Gene' SubClassOf 'G Protein-Coupled Receptor Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125463</classIRI>
<classLabel>GPR158 wt Allele</classLabel>
<newAxiom>'GPR158 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '10p12.31'</newAxiom>
<newAxiom>'GPR158 wt Allele' SubClassOf 'GPR158 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125464</classIRI>
<classLabel>Probable G-Protein Coupled Receptor 158</classLabel>
<newAxiom>'Probable G-Protein Coupled Receptor 158' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane'</newAxiom>
<newAxiom>'Probable G-Protein Coupled Receptor 158' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'GPR158 Gene'</newAxiom>
<newAxiom>'Probable G-Protein Coupled Receptor 158' SubClassOf 'G Protein-Coupled Receptor'</newAxiom>
<newAxiom>'Probable G-Protein Coupled Receptor 158' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'G Protein-Coupled Receptor Signaling'</newAxiom>
<newAxiom>'Probable G-Protein Coupled Receptor 158' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125465</classIRI>
<classLabel>ARHGAP11B Gene</classLabel>
<newAxiom>'ARHGAP11B Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Neural Development'</newAxiom>
<newAxiom>'ARHGAP11B Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125460</classIRI>
<classLabel>Stayed the Same</classLabel>
<newAxiom>'Stayed the Same' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125461</classIRI>
<classLabel>Got Worse</classLabel>
<newAxiom>'Got Worse' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125489</classIRI>
<classLabel>PDE9A Gene</classLabel>
<newAxiom>'PDE9A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Nucleotide Metabolic Process'</newAxiom>
<newAxiom>'PDE9A Gene' SubClassOf 'Esterase Gene'</newAxiom>
<newAxiom>'PDE9A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125488</classIRI>
<classLabel>Seckel Syndrome</classLabel>
<newAxiom>'Seckel Syndrome' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
<newAxiom>'Seckel Syndrome' SubClassOf 'Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125490</classIRI>
<classLabel>PDE9A wt Allele</classLabel>
<newAxiom>'PDE9A wt Allele' EquivalentTo 'PDE9A Gene' and ('Gene_Is_Element_In_Pathway' some 'Purine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Androgen Receptor Regulation Pathway') and ('Gene_In_Chromosomal_Location' some '21q22.3')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125493</classIRI>
<classLabel>Second Trimester Antepartum Hemorrhage</classLabel>
<newAxiom>'Second Trimester Antepartum Hemorrhage' SubClassOf 'Antepartum Hemorrhage'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125494</classIRI>
<classLabel>Third Trimester Antepartum Hemorrhage</classLabel>
<newAxiom>'Third Trimester Antepartum Hemorrhage' SubClassOf 'Antepartum Hemorrhage'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125491</classIRI>
<classLabel>High Affinity cGMP-Specific 3',5'-Cyclic Phosphodiesterase 9A</classLabel>
<newAxiom>'High Affinity cGMP-Specific 3',5'-Cyclic Phosphodiesterase 9A' EquivalentTo 'Esterase' and ('Gene_Product_Is_Element_In_Pathway' some 'Purine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Androgen Receptor Regulation Pathway') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Nucleotide Metabolic Process') and ('Gene_Product_Encoded_By_Gene' some 'PDE9A Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125492</classIRI>
<classLabel>First Trimester Antepartum Hemorrhage</classLabel>
<newAxiom>'First Trimester Antepartum Hemorrhage' SubClassOf 'Antepartum Hemorrhage'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125497</classIRI>
<classLabel>cGMP-Dependent Protein Kinase 1</classLabel>
<newAxiom>'cGMP-Dependent Protein Kinase 1' EquivalentTo 'Serine/Threonine Protein Kinase' and ('Gene_Product_Is_Element_In_Pathway' some 'Long-Term Depression Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Gap Junction Assembly Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Vascular Smooth Muscle Contraction Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Olfactory Transduction Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Salivary Secretion Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Serine/Threonine Phosphorylation') and ('Gene_Product_Encoded_By_Gene' some 'PRKG1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125498</classIRI>
<classLabel>ID4 Gene</classLabel>
<newAxiom>'ID4 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Developmental Process'</newAxiom>
<newAxiom>'ID4 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Protein-Protein Interaction'</newAxiom>
<newAxiom>'ID4 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Repression'</newAxiom>
<newAxiom>'ID4 Gene' SubClassOf 'Transcription Repressor/Corepressor Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125495</classIRI>
<classLabel>PRKG1 Gene</classLabel>
<newAxiom>'PRKG1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Serine/Threonine Phosphorylation'</newAxiom>
<newAxiom>'PRKG1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'PRKG1 Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125496</classIRI>
<classLabel>PRKG1 wt Allele</classLabel>
<newAxiom>'PRKG1 wt Allele' EquivalentTo 'PRKG1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Long-Term Depression Pathway') and ('Gene_Is_Element_In_Pathway' some 'Gap Junction Assembly Pathway') and ('Gene_Is_Element_In_Pathway' some 'Vascular Smooth Muscle Contraction Pathway') and ('Gene_Is_Element_In_Pathway' some 'Olfactory Transduction Pathway') and ('Gene_Is_Element_In_Pathway' some 'Salivary Secretion Pathway') and ('Gene_In_Chromosomal_Location' some '10q11.2')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125478</classIRI>
<classLabel>Ann Arbor Clinical Stage IV</classLabel>
<newAxiom>'Ann Arbor Clinical Stage IV' SubClassOf 'Ann Arbor Lymphoma Staging System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125477</classIRI>
<classLabel>Ann Arbor Pathologic Stage III</classLabel>
<newAxiom>'Ann Arbor Pathologic Stage III' SubClassOf 'Ann Arbor Lymphoma Staging System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125479</classIRI>
<classLabel>Ann Arbor Pathologic Stage IV</classLabel>
<newAxiom>'Ann Arbor Pathologic Stage IV' SubClassOf 'Ann Arbor Lymphoma Staging System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125480</classIRI>
<classLabel>Curcuminoid</classLabel>
<newAxiom>'Curcuminoid' SubClassOf 'Chemopreventive Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125481</classIRI>
<classLabel>GAIA Terminology</classLabel>
<newAxiom>'GAIA Terminology' SubClassOf 'Terminology Subset'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125482</classIRI>
<classLabel>RNF5 Gene</classLabel>
<newAxiom>'RNF5 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Unfolded Protein Response'</newAxiom>
<newAxiom>'RNF5 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Polyubiquitination'</newAxiom>
<newAxiom>'RNF5 Gene' SubClassOf 'Ubiquitin Ligase Gene'</newAxiom>
<newAxiom>'RNF5 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Ubiquitinated Protein Degradation'</newAxiom>
<newAxiom>'RNF5 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Monoubiquitination'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125483</classIRI>
<classLabel>RNF5 wt Allele</classLabel>
<newAxiom>'RNF5 wt Allele' SubClassOf 'RNF5 Gene'</newAxiom>
<newAxiom>'RNF5 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '6p21.3'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125484</classIRI>
<classLabel>Ectopia Lentis</classLabel>
<newAxiom>'Ectopia Lentis' SubClassOf 'Lens Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125485</classIRI>
<classLabel>Microcornea</classLabel>
<newAxiom>'Microcornea' SubClassOf 'Non-Neoplastic Corneal Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125486</classIRI>
<classLabel>E3 Ubiquitin-Protein Ligase RNF5</classLabel>
<newAxiom>'E3 Ubiquitin-Protein Ligase RNF5' EquivalentTo 'E3 Ubiquitin Ligase' and ('Gene_Product_Has_Chemical_Classification' some 'Transmembrane Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane') and ('Gene_Product_Has_Associated_Anatomy' some 'Mitochondrial Membrane') and ('Gene_Product_Has_Associated_Anatomy' some 'Membrane of the Rough Endoplasmic Reticulum') and ('Gene_Product_Has_Associated_Anatomy' some 'Membrane of the Smooth Endoplasmic Reticulum') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Transmembrane Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Ring Finger Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Unfolded Protein Response') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Ubiquitinated Protein Degradation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Polyubiquitination') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Monoubiquitination') and ('Gene_Product_Encoded_By_Gene' some 'RNF5 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125487</classIRI>
<classLabel>Opitz G/BBB Syndrome</classLabel>
<newAxiom>'Opitz G/BBB Syndrome' SubClassOf 'Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125428</classIRI>
<classLabel>Clinical Trial Ongoing Third Party Oversight Document</classLabel>
<newAxiom>'Clinical Trial Ongoing Third Party Oversight Document' SubClassOf 'Document'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125429</classIRI>
<classLabel>Cinical Trial Roles and Responsibilities Matrix</classLabel>
<newAxiom>'Cinical Trial Roles and Responsibilities Matrix' SubClassOf 'Document'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125426</classIRI>
<classLabel>Clinical Trial Coordinating Investigator Documentation</classLabel>
<newAxiom>'Clinical Trial Coordinating Investigator Documentation' SubClassOf 'Clinical Trial Investigator Site Documentation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125427</classIRI>
<classLabel>Clinical Trial Subject Eligibility Verification Form and Worksheet</classLabel>
<newAxiom>'Clinical Trial Subject Eligibility Verification Form and Worksheet' SubClassOf 'Form'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125424</classIRI>
<classLabel>Clinical Trial Committee Member Confidentiality Disclosure Agreement</classLabel>
<newAxiom>'Clinical Trial Committee Member Confidentiality Disclosure Agreement' SubClassOf 'Clinical Trial Agreement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125425</classIRI>
<classLabel>Clinical Trial Team Training Document</classLabel>
<newAxiom>'Clinical Trial Team Training Document' SubClassOf 'Document'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125422</classIRI>
<classLabel>Clinical Study Committe Financial Disclosure Form</classLabel>
<newAxiom>'Clinical Study Committe Financial Disclosure Form' SubClassOf 'Financial Disclosure Form'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125423</classIRI>
<classLabel>Clinical Trial Committe Member Contract</classLabel>
<newAxiom>'Clinical Trial Committe Member Contract' SubClassOf 'Contractual Agreement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125432</classIRI>
<classLabel>Clinical Trial Medical Device Investigators Agreement</classLabel>
<newAxiom>'Clinical Trial Medical Device Investigators Agreement' SubClassOf 'Document'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125431</classIRI>
<classLabel>Medical Device Report of Prior Investigations</classLabel>
<newAxiom>'Medical Device Report of Prior Investigations' SubClassOf 'Report'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125430</classIRI>
<classLabel>Clinical Trial Device Review Committee</classLabel>
<newAxiom>'Clinical Trial Device Review Committee' SubClassOf 'Committee'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125421</classIRI>
<classLabel>Clinical Trial Operational Oversight</classLabel>
<newAxiom>'Clinical Trial Operational Oversight' SubClassOf 'Management'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125446</classIRI>
<classLabel>Profilin-1</classLabel>
<newAxiom>'Profilin-1' EquivalentTo 'Actin-Binding Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'Extracellular Matrix Binding Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Rho Cell Motility Signaling Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Salmonella Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Actin Cytoskeleton Regulation Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Shigellosis Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Actin Filament') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cytoskeletal Modeling') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction Inhibition') and ('Gene_Product_Encoded_By_Gene' some 'PFN1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125447</classIRI>
<classLabel>PTPN14 Gene</classLabel>
<newAxiom>'PTPN14 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cellular Migration Process'</newAxiom>
<newAxiom>'PTPN14 Gene' SubClassOf 'Non-Receptor Protein Tyrosine Phosphatase Gene'</newAxiom>
<newAxiom>'PTPN14 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Protein Dephosphorylation'</newAxiom>
<newAxiom>'PTPN14 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cell Adhesion Process'</newAxiom>
<newAxiom>'PTPN14 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Histogenic Process'</newAxiom>
<newAxiom>'PTPN14 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125444</classIRI>
<classLabel>PFN1 Gene</classLabel>
<newAxiom>'PFN1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cytoskeletal Modeling'</newAxiom>
<newAxiom>'PFN1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction Inhibition'</newAxiom>
<newAxiom>'PFN1 Gene' SubClassOf 'Ligand Binding Protein Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125445</classIRI>
<classLabel>PFN1 wt Allele</classLabel>
<newAxiom>'PFN1 wt Allele' EquivalentTo 'PFN1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Extracellular Matrix Binding Pathway') and ('Gene_Is_Element_In_Pathway' some 'Rho Cell Motility Signaling Pathway') and ('Gene_Is_Element_In_Pathway' some 'Salmonella Pathway') and ('Gene_Is_Element_In_Pathway' some 'Actin Cytoskeleton Regulation Pathway') and ('Gene_Is_Element_In_Pathway' some 'Shigellosis Pathway') and ('Gene_In_Chromosomal_Location' some '17p13.3')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125448</classIRI>
<classLabel>PTPN14 wt Allele</classLabel>
<newAxiom>'PTPN14 wt Allele' SubClassOf 'PTPN14 Gene'</newAxiom>
<newAxiom>'PTPN14 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '1q32.2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125449</classIRI>
<classLabel>Tyrosine-Protein Phosphatase Non-Receptor Type 14</classLabel>
<newAxiom>'Tyrosine-Protein Phosphatase Non-Receptor Type 14' EquivalentTo 'Non-Receptor Type Protein Tyrosine Phosphatase' and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Protein Dephosphorylation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Histogenic Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cellular Migration Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cell Adhesion Process') and ('Gene_Product_Encoded_By_Gene' some 'PTPN14 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125450</classIRI>
<classLabel>JAK2 Inhibitor</classLabel>
<newAxiom>'JAK2 Inhibitor' SubClassOf 'Tyrosine Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125454</classIRI>
<classLabel>Recommend Participating in Research Study to Others</classLabel>
<newAxiom>'Recommend Participating in Research Study to Others' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125453</classIRI>
<classLabel>Would Participate in Research Study Again</classLabel>
<newAxiom>'Would Participate in Research Study Again' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125452</classIRI>
<classLabel>Worthwhile to Participate in Research Study</classLabel>
<newAxiom>'Worthwhile to Participate in Research Study' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125451</classIRI>
<classLabel>Was It Worth It Questionnaire</classLabel>
<newAxiom>'Was It Worth It Questionnaire' SubClassOf 'Clinical or Research Assessment Questionnaire'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125433</classIRI>
<classLabel>Source Data Verification</classLabel>
<newAxiom>'Source Data Verification' SubClassOf 'Document'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125434</classIRI>
<classLabel>Clinical Trial Subject Identification Log</classLabel>
<newAxiom>'Clinical Trial Subject Identification Log' SubClassOf 'Log'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125435</classIRI>
<classLabel>Investigational Product Retest and Expiry Document</classLabel>
<newAxiom>'Investigational Product Retest and Expiry Document' SubClassOf 'Document'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125436</classIRI>
<classLabel>Investigational Product Device Maintenance Log</classLabel>
<newAxiom>'Investigational Product Device Maintenance Log' SubClassOf 'Log'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125437</classIRI>
<classLabel>Electronic Case Report Form Technical Design Document</classLabel>
<newAxiom>'Electronic Case Report Form Technical Design Document' SubClassOf 'Document'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125438</classIRI>
<classLabel>Clinical Trial Patient Database Change Control</classLabel>
<newAxiom>'Clinical Trial Patient Database Change Control' SubClassOf 'Document'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125439</classIRI>
<classLabel>Independent Review Committee Member Curriculum Vitae</classLabel>
<newAxiom>'Independent Review Committee Member Curriculum Vitae' SubClassOf 'Curriculum Vitae'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125441</classIRI>
<classLabel>Clinical Trial Team Curriculum Vitae</classLabel>
<newAxiom>'Clinical Trial Team Curriculum Vitae' SubClassOf 'Curriculum Vitae'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125440</classIRI>
<classLabel>Clinical Trials Third Party Curriculum Vitae</classLabel>
<newAxiom>'Clinical Trials Third Party Curriculum Vitae' SubClassOf 'Curriculum Vitae'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125443</classIRI>
<classLabel>Clinical Trial Monitoring Visit Follow-up Letter</classLabel>
<newAxiom>'Clinical Trial Monitoring Visit Follow-up Letter' SubClassOf 'Letter'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125442</classIRI>
<classLabel>Clinical Trial Source Data</classLabel>
<newAxiom>'Clinical Trial Source Data' SubClassOf 'Data'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125500</classIRI>
<classLabel>DNA-Binding Protein Inhibitor ID-4</classLabel>
<newAxiom>'DNA-Binding Protein Inhibitor ID-4' EquivalentTo 'Transcription Regulatory Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'TGF-beta Signaling Pathway KEGG') and ('Gene_Product_Has_Chemical_Classification' some 'BHLH Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleus') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'bHLH Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Transcription Repressor/Corepressor') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Repression') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Developmental Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Heterodimerization') and ('Gene_Product_Encoded_By_Gene' some 'ID4 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125502</classIRI>
<classLabel>MAOB Gene</classLabel>
<newAxiom>'MAOB Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Biogenic Amine Metabolic Process'</newAxiom>
<newAxiom>'MAOB Gene' SubClassOf 'Oxidoreductase Gene'</newAxiom>
<newAxiom>'MAOB Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Oxidation/Reduction'</newAxiom>
<newAxiom>'MAOB Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Xenobiotic Metabolism'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125501</classIRI>
<classLabel>Patient Satisfaction Questionnaire Short Form</classLabel>
<newAxiom>'Patient Satisfaction Questionnaire Short Form' SubClassOf 'Clinical or Research Assessment Questionnaire'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125504</classIRI>
<classLabel>MAOB wt Allele</classLabel>
<newAxiom>'MAOB wt Allele' EquivalentTo 'MAOB Gene' and ('Gene_Is_Element_In_Pathway' some 'Arginine and Proline Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Glycine, Serine and Threonine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Histidine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Phenylalanine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Tryptophan Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Tyrosine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Drug Metabolism by Cytochrome P450 Pathway') and ('Gene_Is_Element_In_Pathway' some 'Alpha-Synuclein Signaling Pathway') and ('Gene_In_Chromosomal_Location' some 'Xp11.23')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125503</classIRI>
<classLabel>Doctors are Good About Explaining the Reasons for Medical Tests</classLabel>
<newAxiom>'Doctors are Good About Explaining the Reasons for Medical Tests' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125506</classIRI>
<classLabel>Doctor's Office Has Everything Needed to Provide Complete Medical Care</classLabel>
<newAxiom>'Doctor's Office Has Everything Needed to Provide Complete Medical Care' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125505</classIRI>
<classLabel>Amine Oxidase [Flavin-Containing] B</classLabel>
<newAxiom>'Amine Oxidase [Flavin-Containing] B' EquivalentTo 'Oxidoreductase' and ('Gene_Product_Is_Element_In_Pathway' some 'Arginine and Proline Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Glycine, Serine and Threonine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Histidine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Phenylalanine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Tryptophan Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Tyrosine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Drug Metabolism by Cytochrome P450 Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Alpha-Synuclein Signaling Pathway') and ('Gene_Product_Has_Chemical_Classification' some 'Transmembrane Protein') and ('Gene_Product_Has_Chemical_Classification' some 'Mitochondrial Membrane Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Outer Mitochondrial Membrane') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Transmembrane Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Oxidation/Reduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Xenobiotic Metabolism') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Biogenic Amine Metabolic Process') and ('Gene_Product_Encoded_By_Gene' some 'MAOB Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125508</classIRI>
<classLabel>Sometimes Doctors Make Me Wonder if Their Diagnosis is Correct</classLabel>
<newAxiom>'Sometimes Doctors Make Me Wonder if Their Diagnosis is Correct' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125507</classIRI>
<classLabel>Medical Care I Have Been Receiving is Just About Perfect</classLabel>
<newAxiom>'Medical Care I Have Been Receiving is Just About Perfect' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125509</classIRI>
<classLabel>Confident That I Can Get the Medical Care I Need Without Being Set Back Financially</classLabel>
<newAxiom>'Confident That I Can Get the Medical Care I Need Without Being Set Back Financially' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125520</classIRI>
<classLabel>Find it Hard to Get an Appointment for Medical Care Right Away</classLabel>
<newAxiom>'Find it Hard to Get an Appointment for Medical Care Right Away' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125517</classIRI>
<classLabel>Doctors Sometimes Ignore What I Tell Them</classLabel>
<newAxiom>'Doctors Sometimes Ignore What I Tell Them' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125516</classIRI>
<classLabel>Those Providing Medical Care Sometimes Hurry Too Much When They Treat Me</classLabel>
<newAxiom>'Those Providing Medical Care Sometimes Hurry Too Much When They Treat Me' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125515</classIRI>
<classLabel>Doctors Treat Me In a Very Friendly and Courteous Manner</classLabel>
<newAxiom>'Doctors Treat Me In a Very Friendly and Courteous Manner' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125514</classIRI>
<classLabel>Doctors Act Too Businesslike and Impersonal Toward Me</classLabel>
<newAxiom>'Doctors Act Too Businesslike and Impersonal Toward Me' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125513</classIRI>
<classLabel>Wait for Emergency Treatment is Too Long Where I Get Medical Care</classLabel>
<newAxiom>'Wait for Emergency Treatment is Too Long Where I Get Medical Care' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125512</classIRI>
<classLabel>Have Easy Access to the Medical Specialists I Need</classLabel>
<newAxiom>'Have Easy Access to the Medical Specialists I Need' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125511</classIRI>
<classLabel>Have to Pay More of My Medical Care Than I Can Afford</classLabel>
<newAxiom>'Have to Pay More of My Medical Care Than I Can Afford' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125510</classIRI>
<classLabel>Doctors are Careful to Check Everything When Treating and Examining Me</classLabel>
<newAxiom>'Doctors are Careful to Check Everything When Treating and Examining Me' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125519</classIRI>
<classLabel>Doctors Usually Spend Plenty of Time With Me</classLabel>
<newAxiom>'Doctors Usually Spend Plenty of Time With Me' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125518</classIRI>
<classLabel>Have Some Doubts About the Ability of the Doctors Who Treat Me</classLabel>
<newAxiom>'Have Some Doubts About the Ability of the Doctors Who Treat Me' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125530</classIRI>
<classLabel>How Important Treatment Based on Tumor Molecular Profile Extends Survival</classLabel>
<newAxiom>'How Important Treatment Based on Tumor Molecular Profile Extends Survival' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125531</classIRI>
<classLabel>How Important Treatment Based on Tumor Molecular Profile Improves Symptoms</classLabel>
<newAxiom>'How Important Treatment Based on Tumor Molecular Profile Improves Symptoms' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125526</classIRI>
<classLabel>PARD3 Gene</classLabel>
<newAxiom>'PARD3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'G Protein-Coupled Receptor Signaling'</newAxiom>
<newAxiom>'PARD3 Gene' SubClassOf 'Adaptor Signaling Protein Gene'</newAxiom>
<newAxiom>'PARD3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cell Division Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125525</classIRI>
<classLabel>Zinc Transporter ZIP6</classLabel>
<newAxiom>'Zinc Transporter ZIP6' EquivalentTo 'Transport Protein' and ('Gene_Product_Has_Chemical_Classification' some 'Transmembrane Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Transmembrane Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Coiled-Coil Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Solute Carrier Family') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transmembrane Transport') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Ion Transport Process') and ('Gene_Product_Encoded_By_Gene' some 'SLC39A6 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125528</classIRI>
<classLabel>Attitudes and Preferences Questionnaire</classLabel>
<newAxiom>'Attitudes and Preferences Questionnaire' SubClassOf 'Clinical or Research Assessment Questionnaire'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125527</classIRI>
<classLabel>PARD3 wt Allele</classLabel>
<newAxiom>'PARD3 wt Allele' EquivalentTo 'PARD3 Gene' and ('Gene_Is_Element_In_Pathway' some 'Neuroactive Ligand-Receptor Signaling Pathway') and ('Gene_Is_Element_In_Pathway' some 'Adherens Junction Assembly Pathway') and ('Gene_Is_Element_In_Pathway' some 'Endocytosis Pathway') and ('Gene_Is_Element_In_Pathway' some 'Tight Junction Assembly Pathway') and ('Gene_Is_Element_In_Pathway' some 'Chemokine Signaling Pathway') and ('Gene_In_Chromosomal_Location' some '10p11.21')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125522</classIRI>
<classLabel>Able to Get Medical Care Whenever I Need It</classLabel>
<newAxiom>'Able to Get Medical Care Whenever I Need It' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125521</classIRI>
<classLabel>Dissatisfied With Some Things About the Medical Care I Receive</classLabel>
<newAxiom>'Dissatisfied With Some Things About the Medical Care I Receive' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125524</classIRI>
<classLabel>SLC39A6 wt Allele</classLabel>
<newAxiom>'SLC39A6 wt Allele' SubClassOf 'SLC39A6 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125523</classIRI>
<classLabel>SLC39A6 Gene</classLabel>
<newAxiom>'SLC39A6 Gene' SubClassOf 'Transport Protein Gene'</newAxiom>
<newAxiom>'SLC39A6 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Ion Transport Process'</newAxiom>
<newAxiom>'SLC39A6 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transmembrane Transport'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125529</classIRI>
<classLabel>Partitioning Defective 3 Homolog</classLabel>
<newAxiom>'Partitioning Defective 3 Homolog' EquivalentTo 'Adaptor Signaling Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'Neuroactive Ligand-Receptor Signaling Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Adherens Junction Assembly Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Endocytosis Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Tight Junction Assembly Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Chemokine Signaling Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Cell Junction') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Coiled-Coil Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cell Division Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'G Protein-Coupled Receptor Signaling') and ('Gene_Product_Encoded_By_Gene' some 'PARD3 Gene')</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
</deletedClasses>
</diffReport>