<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
455
</numberChangedClasses>
<numberNewClasses>
318
</numberNewClasses>
<numberDeletedClasses>
0
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105147</classIRI>
<classLabel>Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015</classLabel>
<deletedAxiom>&apos;Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C92859</classIRI>
<classLabel>Prenatal HIV Screening</classLabel>
<deletedAxiom>&apos;Prenatal HIV Screening&apos; SubClassOf &apos;Viral Screening&apos;</deletedAxiom>
<newAxiom>&apos;Prenatal HIV Screening&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191960</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C130011</classIRI>
<classLabel>Anti-HER2 Antibody-drug Conjugate RC48</classLabel>
<deletedAxiom>&apos;Anti-HER2 Antibody-drug Conjugate RC48&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-HER2 Antibody-drug Conjugate RC48&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C119658</classIRI>
<classLabel>DGKH Gene</classLabel>
<deletedAxiom>&apos;DGKH Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Phosphorylation Process&apos;</deletedAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158914</classIRI>
<classLabel>Locally Advanced Prostate Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Locally Advanced Prostate Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Locally Advanced Prostate Carcinoma&apos; and &apos;Locally Advanced Neuroendocrine Carcinoma&apos; and &apos;Metastatic Prostate Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Locally Advanced Prostate Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Locally Advanced Prostate Carcinoma&apos; and &apos;Metastatic Prostate Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191983</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158912</classIRI>
<classLabel>Prostate Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Prostate Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and &apos;Invasive Prostate Carcinoma&apos; and &apos;Prostate Neuroendocrine Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Prostate Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Invasive Prostate Carcinoma&apos; and &apos;Prostate Neuroendocrine Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158913</classIRI>
<classLabel>Metastatic Prostate Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Metastatic Prostate Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Metastatic Neuroendocrine Carcinoma&apos; and &apos;Prostate Neuroendocrine Carcinoma&apos; and &apos;Metastatic Prostate Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Prostate Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Prostate Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191981 and &apos;Metastatic Prostate Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3234</classIRI>
<classLabel>Mesothelioma</classLabel>
<deletedAxiom>&apos;Mesothelioma&apos; EquivalentTo &apos;Mesothelial Neoplasm&apos; and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Neoplastic Epithelial Cell&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Neoplastic Hematopoietic and Lymphoid Cell&apos;)</deletedAxiom>
<newAxiom>&apos;Mesothelioma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158708</classIRI>
<classLabel>Pre-Adjuvant Therapy</classLabel>
<deletedAxiom>&apos;Pre-Adjuvant Therapy&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Pre-Adjuvant Therapy&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3762</classIRI>
<classLabel>Adenomatoid Tumor</classLabel>
<deletedAxiom>&apos;Adenomatoid Tumor&apos; EquivalentTo &apos;Mesothelioma&apos; and &apos;Benign Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Indolent Clinical Course&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Localized Disease&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Flattened Neoplastic Mesothelial Cell&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Cuboidal Neoplastic Mesothelial Cell&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Malignant Mesothelial Cell&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Atypia&apos;)</deletedAxiom>
<newAxiom>&apos;Adenomatoid Tumor&apos; EquivalentTo &apos;Benign Neoplasm&apos; and &apos;Mesothelial Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Indolent Clinical Course&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Localized Disease&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Flattened Neoplastic Mesothelial Cell&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Cuboidal Neoplastic Mesothelial Cell&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Malignant Mesothelial Cell&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Atypia&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3765</classIRI>
<classLabel>Multicystic Mesothelioma</classLabel>
<deletedAxiom>&apos;Multicystic Mesothelioma&apos; EquivalentTo &apos;Mesothelioma&apos; and &apos;Neoplasm of Uncertain Malignant Potential&apos; and &apos;Cystic Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Multilocular Lesion&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Flattened Neoplastic Mesothelial Cell&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Cuboidal Neoplastic Mesothelial Cell&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Inflammatory Infiltrate&apos;)</deletedAxiom>
<newAxiom>&apos;Multicystic Mesothelioma&apos; EquivalentTo &apos;Mesothelial Neoplasm&apos; and &apos;Cystic Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Multilocular Lesion&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Flattened Neoplastic Mesothelial Cell&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Cuboidal Neoplastic Mesothelial Cell&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Inflammatory Infiltrate&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158650</classIRI>
<classLabel>Prostate Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Prostate Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Prostate Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Prostate Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Prostate Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3642</classIRI>
<classLabel>Grade III Prostatic Intraepithelial Neoplasia</classLabel>
<deletedAxiom>&apos;Grade III Prostatic Intraepithelial Neoplasia&apos; EquivalentTo &apos;High Grade Prostatic Intraepithelial Neoplasia&apos; and &apos;Grade III Glandular Intraepithelial Neoplasia&apos; and &apos;Malignant Prostate Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Grade III Prostatic Intraepithelial Neoplasia&apos; EquivalentTo &apos;Prostate Carcinoma&apos; and &apos;High Grade Prostatic Intraepithelial Neoplasia&apos; and &apos;Grade III Glandular Intraepithelial Neoplasia&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3614</classIRI>
<classLabel>Benign Epididymal Neoplasm</classLabel>
<deletedAxiom>&apos;Benign Epididymal Neoplasm&apos; EquivalentTo &apos;Epididymal Neoplasm&apos; and &apos;Benign Male Reproductive System Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Epididymis&apos;)</deletedAxiom>
<newAxiom>&apos;Benign Epididymal Neoplasm&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140 and &apos;Epididymal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Epididymis&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3558</classIRI>
<classLabel>Malignant Epididymal Neoplasm</classLabel>
<deletedAxiom>&apos;Malignant Epididymal Neoplasm&apos; EquivalentTo &apos;Epididymal Neoplasm&apos; and &apos;Malignant Male Reproductive System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Malignant Epididymal Neoplasm&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192139 and &apos;Epididymal Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3559</classIRI>
<classLabel>Malignant Spermatic Cord Neoplasm</classLabel>
<deletedAxiom>&apos;Malignant Spermatic Cord Neoplasm&apos; EquivalentTo &apos;Malignant Male Reproductive System Neoplasm&apos; and (&apos;Disease_Has_Associated_Anatomic_Site&apos; some &apos;Spermatic Cord&apos;)</deletedAxiom>
<newAxiom>&apos;Malignant Spermatic Cord Neoplasm&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192139 and (&apos;Disease_Has_Associated_Anatomic_Site&apos; some &apos;Spermatic Cord&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3422</classIRI>
<classLabel>Trophoblastic Tumor</classLabel>
<deletedAxiom>&apos;Trophoblastic Tumor&apos; EquivalentTo &apos;Neoplasm by Morphology&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Trophoblastic Cell&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Mixture of Germ Cell Neoplastic Components Present&apos;)</deletedAxiom>
<newAxiom>&apos;Trophoblastic Tumor&apos; EquivalentTo &apos;Epithelial Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Trophoblastic Cell&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158127</classIRI>
<classLabel>Geriatric Depression Scale Short Form Questionnaire Question</classLabel>
<deletedAxiom>&apos;Geriatric Depression Scale Short Form Questionnaire Question&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Geriatric Depression Scale Short Form Questionnaire Question&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C183128</classIRI>
<classLabel>Recurrent Extrapulmonary Small Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Recurrent Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; and &apos;Recurrent Small Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; and &apos;Recurrent Small Cell Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191978</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C124514</classIRI>
<classLabel>Collapsed Lumen</classLabel>
<deletedAxiom>&apos;Collapsed Lumen&apos; SubClassOf &apos;Congenital or Acquired Anatomic Abnormality&apos;</deletedAxiom>
<newAxiom>&apos;Collapsed Lumen&apos; SubClassOf &apos;Finding by Cause&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3964</classIRI>
<classLabel>Dihydrouracil Dehydrogenase Deficiency</classLabel>
<deletedAxiom>&apos;Dihydrouracil Dehydrogenase Deficiency&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Dihydrouracil Dehydrogenase Deficiency&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3916</classIRI>
<classLabel>Parathyroid Gland Adenoma</classLabel>
<deletedAxiom>&apos;Parathyroid Gland Adenoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Parathyroid Gland Adenoma&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C124651</classIRI>
<classLabel>GITR Agonist MEDI1873</classLabel>
<deletedAxiom>&apos;GITR Agonist MEDI1873&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;GITR Agonist MEDI1873&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150552</classIRI>
<classLabel>SERD G1T48</classLabel>
<deletedAxiom>&apos;SERD G1T48&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;SERD G1T48&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125700</classIRI>
<classLabel>Ehlers-Danlos Syndrome, Type VI</classLabel>
<deletedAxiom>&apos;Ehlers-Danlos Syndrome, Type VI&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some &apos;COL5A1 Gene&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73823</classIRI>
<classLabel>Raltegravir Potassium</classLabel>
<deletedAxiom>&apos;Raltegravir Potassium&apos; SubClassOf &apos;Antiviral Agent&apos;</deletedAxiom>
<newAxiom>&apos;Raltegravir Potassium&apos; SubClassOf &apos;HIV Integrase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150100</classIRI>
<classLabel>DGKZ Gene</classLabel>
<deletedAxiom>&apos;DGKZ Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Phosphorylation Process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150221</classIRI>
<classLabel>Dynein Heavy Chain 9, Axonemal</classLabel>
<deletedAxiom>&apos;Dynein Heavy Chain 9, Axonemal&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cilium&apos;</deletedAxiom>
<deletedAxiom>&apos;Dynein Heavy Chain 9, Axonemal&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Microtubule Process&apos;</deletedAxiom>
<deletedAxiom>&apos;Dynein Heavy Chain 9, Axonemal&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNAH9 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;Dynein Heavy Chain 9, Axonemal&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;</deletedAxiom>
<deletedAxiom>&apos;Dynein Heavy Chain 9, Axonemal&apos; SubClassOf &apos;Microtubule Associated Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;Dynein Heavy Chain 9, Axonemal&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cilium Microtubule&apos;</deletedAxiom>
<deletedAxiom>&apos;Dynein Heavy Chain 9, Axonemal&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ATPase Domain&apos;</deletedAxiom>
<deletedAxiom>&apos;Dynein Heavy Chain 9, Axonemal&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;</deletedAxiom>
<deletedAxiom>&apos;Dynein Heavy Chain 9, Axonemal&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;</deletedAxiom>
<newAxiom>&apos;Dynein Heavy Chain 9, Axonemal&apos; EquivalentTo &apos;Transport Protein&apos; and &apos;Microtubule Associated Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Huntington&apos;s Disease Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cilium&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cilium Microtubule&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;ATPase Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;ATPase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Microtubule Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DNAH9 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150218</classIRI>
<classLabel>DNAH9 Gene</classLabel>
<newAxiom>&apos;DNAH9 Gene&apos; SubClassOf &apos;Trafficking Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150214</classIRI>
<classLabel>CMPK1 Gene</classLabel>
<deletedAxiom>&apos;CMPK1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Phosphorylation Process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34801</classIRI>
<classLabel>Male Erectile Disorder</classLabel>
<deletedAxiom>&apos;Male Erectile Disorder&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Male Erectile Disorder&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178933</classIRI>
<classLabel>HEPES Solution</classLabel>
<deletedAxiom>&apos;HEPES Solution&apos; SubClassOf &apos;Buffer&apos;</deletedAxiom>
<newAxiom>&apos;HEPES Solution&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178701</classIRI>
<classLabel>SeroNet Terminology</classLabel>
<newAxiom>&apos;SeroNet Terminology&apos; SubClassOf &apos;COVID-19 Terminology&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C164224</classIRI>
<classLabel>Spastic Paraplegia 47</classLabel>
<newAxiom>&apos;Spastic Paraplegia 47&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191967</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68658</classIRI>
<classLabel>Malignant Trophoblastic Cell</classLabel>
<deletedAxiom>&apos;Malignant Trophoblastic Cell&apos; SubClassOf &apos;Malignant Cell&apos;</deletedAxiom>
<newAxiom>&apos;Malignant Trophoblastic Cell&apos; SubClassOf &apos;Malignant Epithelial Cell&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20899</classIRI>
<classLabel>ELF3 Gene</classLabel>
<newAxiom>&apos;ELF3 Gene&apos; SubClassOf &apos;ETS Family Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178411</classIRI>
<classLabel>Amyotrophic Lateral Sclerosis 23</classLabel>
<newAxiom>&apos;Amyotrophic Lateral Sclerosis 23&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191964</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118458</classIRI>
<classLabel>Cheiromegaly</classLabel>
<deletedAxiom>&apos;Cheiromegaly&apos; SubClassOf &apos;Congenital or Acquired Anatomic Abnormality&apos;</deletedAxiom>
<newAxiom>&apos;Cheiromegaly&apos; SubClassOf &apos;Finding by Cause&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118574</classIRI>
<classLabel>Interleukin-2 Fusion Protein MSB0010445</classLabel>
<deletedAxiom>&apos;Interleukin-2 Fusion Protein MSB0010445&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Interleukin-2 Fusion Protein MSB0010445&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40022</classIRI>
<classLabel>Primary Peritoneal Carcinoma</classLabel>
<deletedAxiom>&apos;Primary Peritoneal Carcinoma&apos; EquivalentTo &apos;Carcinoma&apos; and &apos;Malignant Peritoneal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneum&apos;) and (&apos;Disease_Excludes_Primary_Anatomic_Site&apos; some &apos;Ovary&apos;)</deletedAxiom>
<newAxiom>&apos;Primary Peritoneal Carcinoma&apos; EquivalentTo &apos;Carcinoma&apos; and &apos;Malignant Peritoneal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneal Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Peritoneum&apos;) and (&apos;Disease_Excludes_Primary_Anatomic_Site&apos; some &apos;Ovary&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40024</classIRI>
<classLabel>Borderline Peritoneal Serous Tumor</classLabel>
<deletedAxiom>&apos;Borderline Peritoneal Serous Tumor&apos; EquivalentTo &apos;Peritoneal Neoplasm&apos; and &apos;Neoplasm of Uncertain Malignant Potential&apos; and &apos;Serous Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneum&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Micropapillary Growth Pattern&apos;)</deletedAxiom>
<newAxiom>&apos;Borderline Peritoneal Serous Tumor&apos; EquivalentTo &apos;Peritoneal Neoplasm&apos; and &apos;Neoplasm of Uncertain Malignant Potential&apos; and &apos;Serous Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneal Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Peritoneum&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Micropapillary Growth Pattern&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40012</classIRI>
<classLabel>Benign Struma Ovarii</classLabel>
<deletedAxiom>&apos;Benign Struma Ovarii&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Benign Struma Ovarii&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C143251</classIRI>
<classLabel>Anti-CD123 ADC IMGN632</classLabel>
<deletedAxiom>&apos;Anti-CD123 ADC IMGN632&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-CD123 ADC IMGN632&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40214</classIRI>
<classLabel>Cervical Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Cervical Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Cervical Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Cervical Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Cervical Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88290</classIRI>
<classLabel>Short Chain Fatty Acid HQK-1004</classLabel>
<deletedAxiom>&apos;Short Chain Fatty Acid HQK-1004&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Short Chain Fatty Acid HQK-1004&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40356</classIRI>
<classLabel>Breast Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Breast Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Breast Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Breast Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Breast Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88325</classIRI>
<classLabel>Anti-IL-1 alpha Monoclonal Antibody MABp1</classLabel>
<deletedAxiom>&apos;Anti-IL-1 alpha Monoclonal Antibody MABp1&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-IL-1 alpha Monoclonal Antibody MABp1&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40338</classIRI>
<classLabel>Peritoneal Gastrointestinal Stromal Tumor</classLabel>
<deletedAxiom>&apos;Peritoneal Gastrointestinal Stromal Tumor&apos; EquivalentTo &apos;Extragastrointestinal Gastrointestinal Stromal Tumor&apos; and &apos;Peritoneal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneum&apos;)</deletedAxiom>
<newAxiom>&apos;Peritoneal Gastrointestinal Stromal Tumor&apos; EquivalentTo &apos;Extragastrointestinal Gastrointestinal Stromal Tumor&apos; and &apos;Peritoneal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneal Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Peritoneum&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157759</classIRI>
<classLabel>Bladder Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Bladder Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Bladder Neuroendocrine Neoplasm&apos; and &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and &apos;Bladder Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Bladder Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Bladder Neuroendocrine Neoplasm&apos; and &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Bladder Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157760</classIRI>
<classLabel>Bladder Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Bladder Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Bladder Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Bladder Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Bladder Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157762</classIRI>
<classLabel>Metastatic Bladder Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Metastatic Bladder Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Metastatic Bladder Carcinoma&apos; and &apos;Bladder Large Cell Neuroendocrine Carcinoma&apos; and &apos;Metastatic Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Bladder Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Metastatic Bladder Carcinoma&apos; and &apos;Bladder Large Cell Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191988</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157504</classIRI>
<classLabel>Myopathy due to Myoadenylate Deaminase Deficiency</classLabel>
<newAxiom>&apos;Myopathy due to Myoadenylate Deaminase Deficiency&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191929</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157543</classIRI>
<classLabel>Abacavir/Dolutegravir/Lamivudine</classLabel>
<newAxiom>&apos;Abacavir/Dolutegravir/Lamivudine&apos; SubClassOf &apos;HIV Integrase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74008</classIRI>
<classLabel>CD40 Agonist Monoclonal Antibody CP-870,893</classLabel>
<deletedAxiom>&apos;CD40 Agonist Monoclonal Antibody CP-870,893&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;CD40 Agonist Monoclonal Antibody CP-870,893&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C182460</classIRI>
<classLabel>Clinical or Research Assessment Question Response</classLabel>
<deletedAxiom>&apos;Clinical or Research Assessment Question Response&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Clinical or Research Assessment Question Response&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C123844</classIRI>
<classLabel>Childhood Choriocarcinoma</classLabel>
<deletedAxiom>&apos;Childhood Choriocarcinoma&apos; EquivalentTo &apos;Childhood Nongerminomatous Germ Cell Tumor&apos; and &apos;Choriocarcinoma&apos; and &apos;Childhood Malignant Germ Cell Tumor&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Choriocarcinoma&apos; EquivalentTo &apos;Childhood Nongerminomatous Germ Cell Tumor&apos; and &apos;Childhood Carcinoma&apos; and &apos;Choriocarcinoma&apos; and &apos;Childhood Malignant Germ Cell Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2441</classIRI>
<classLabel>Interleukin-4 PE38kdel Immunotoxin</classLabel>
<deletedAxiom>&apos;Interleukin-4 PE38kdel Immunotoxin&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Interleukin-4 PE38kdel Immunotoxin&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157346</classIRI>
<classLabel>Borderline Resectable Malignant Neoplasm</classLabel>
<deletedAxiom>&apos;Borderline Resectable Malignant Neoplasm&apos; EquivalentTo &apos;Resectable Malignant Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Borderline Resectable Mass&apos;)</deletedAxiom>
<newAxiom>&apos;Borderline Resectable Malignant Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157348</classIRI>
<classLabel>Borderline Resectable Pancreatic Carcinoma</classLabel>
<deletedAxiom>&apos;Borderline Resectable Pancreatic Carcinoma&apos; EquivalentTo &apos;Borderline Resectable Carcinoma&apos; and &apos;Resectable Pancreatic Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Borderline Resectable Pancreatic Carcinoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157349</classIRI>
<classLabel>Borderline Resectable Carcinoma</classLabel>
<deletedAxiom>&apos;Borderline Resectable Carcinoma&apos; EquivalentTo &apos;Resectable Carcinoma&apos; and &apos;Borderline Resectable Malignant Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Borderline Resectable Carcinoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157350</classIRI>
<classLabel>Borderline Resectable Pancreatic Adenocarcinoma</classLabel>
<deletedAxiom>&apos;Borderline Resectable Pancreatic Adenocarcinoma&apos; EquivalentTo &apos;Resectable Pancreatic Adenocarcinoma&apos; and &apos;Borderline Resectable Pancreatic Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Borderline Resectable Pancreatic Adenocarcinoma&apos; EquivalentTo &apos;Resectable Pancreatic Ductal Adenocarcinoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Borderline Resectable Mass&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C123433</classIRI>
<classLabel>Hyperlysinemia</classLabel>
<newAxiom>&apos;Hyperlysinemia&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191886</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2879</classIRI>
<classLabel>Tumor of the Diffuse Neuroendocrine System</classLabel>
<deletedAxiom>&apos;Tumor of the Diffuse Neuroendocrine System&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Tumor of the Diffuse Neuroendocrine System&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2712</classIRI>
<classLabel>Monoclonal Antibody E7.6.3</classLabel>
<deletedAxiom>&apos;Monoclonal Antibody E7.6.3&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Monoclonal Antibody E7.6.3&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162706</classIRI>
<classLabel>Metastatic Thyroid Gland Medullary Carcinoma</classLabel>
<deletedAxiom>&apos;Metastatic Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Metastatic Thyroid Gland Carcinoma&apos; and &apos;Metastatic Neuroendocrine Carcinoma&apos; and &apos;Thyroid Gland Medullary Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Metastatic Thyroid Gland Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191981 and &apos;Thyroid Gland Medullary Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162786</classIRI>
<classLabel>Unresectable Merkel Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Unresectable Merkel Cell Carcinoma&apos; EquivalentTo &apos;Unresectable Skin Carcinoma&apos; and &apos;Unresectable Neuroendocrine Carcinoma&apos; and &apos;Merkel Cell Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Unresectable Merkel Cell Carcinoma&apos; EquivalentTo &apos;Unresectable Skin Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191980 and &apos;Merkel Cell Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35262</classIRI>
<classLabel>Hereditary Sideroblastic Anemia</classLabel>
<newAxiom>&apos;Hereditary Sideroblastic Anemia&apos; SubClassOf &apos;Sideroblastic Anemia&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C137990</classIRI>
<classLabel>Mcl-1 Inhibitor</classLabel>
<deletedAxiom>&apos;Mcl-1 Inhibitor&apos; SubClassOf &apos;Apoptotic Pathway-targeting Antineoplastic Agent&apos;</deletedAxiom>
<newAxiom>&apos;Mcl-1 Inhibitor&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192025</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2539</classIRI>
<classLabel>EGFR Inhibitor BIBX 1382</classLabel>
<deletedAxiom>&apos;EGFR Inhibitor BIBX 1382&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;EGFR Inhibitor BIBX 1382&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C137941</classIRI>
<classLabel>Risk Assessment for Hereditary Breast Cancer</classLabel>
<deletedAxiom>&apos;Risk Assessment for Hereditary Breast Cancer&apos; SubClassOf &apos;Risk Assessment&apos;</deletedAxiom>
<newAxiom>&apos;Risk Assessment for Hereditary Breast Cancer&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192108</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2509</classIRI>
<classLabel>Hu14.18-IL2 Fusion Protein EMD 273063</classLabel>
<deletedAxiom>&apos;Hu14.18-IL2 Fusion Protein EMD 273063&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Hu14.18-IL2 Fusion Protein EMD 273063&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162880</classIRI>
<classLabel>5-HT4 Agonist TAK-954</classLabel>
<deletedAxiom>&apos;5-HT4 Agonist TAK-954&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;5-HT4 Agonist TAK-954&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162846</classIRI>
<classLabel>Regulatory Action</classLabel>
<deletedAxiom>&apos;Regulatory Action&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Regulatory Action&apos; SubClassOf &apos;Administrative Activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74967</classIRI>
<classLabel>Homeobox Protein Aristaless-Like 4</classLabel>
<deletedAxiom>&apos;Homeobox Protein Aristaless-Like 4&apos; EquivalentTo &apos;Transcription Factor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Homeobox Family Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Homeo Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Limb Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALX4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Homeobox Protein Aristaless-Like 4&apos; EquivalentTo &apos;Transcription Factor&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Homeobox Family Protein&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Homeo Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Proline-Rich Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Sequence-Specific DNA Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Limb Development&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALX4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35496</classIRI>
<classLabel>Chemically Induced Cytotoxicity</classLabel>
<newAxiom>&apos;Chemically Induced Cytotoxicity&apos; SubClassOf &apos;Cytotoxicity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163974</classIRI>
<classLabel>Unresectable Thyroid Gland Medullary Carcinoma</classLabel>
<deletedAxiom>&apos;Unresectable Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Unresectable Thyroid Gland Carcinoma&apos; and &apos;Unresectable Neuroendocrine Carcinoma&apos; and &apos;Thyroid Gland Medullary Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Unresectable Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Unresectable Thyroid Gland Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191980 and &apos;Thyroid Gland Medullary Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163957</classIRI>
<classLabel>Metastatic Pituitary Gland Carcinoma</classLabel>
<deletedAxiom>&apos;Metastatic Pituitary Gland Carcinoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Pituitary Gland Carcinoma&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163964</classIRI>
<classLabel>Advanced Thyroid Gland Medullary Carcinoma</classLabel>
<deletedAxiom>&apos;Advanced Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Advanced Neuroendocrine Carcinoma&apos; and &apos;Metastatic Thyroid Gland Medullary Carcinoma&apos; and &apos;Advanced Thyroid Gland Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Advanced Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Metastatic Thyroid Gland Medullary Carcinoma&apos; and &apos;Advanced Thyroid Gland Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191982</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35570</classIRI>
<classLabel>Chemically Induced Urinary Tract Toxicity</classLabel>
<newAxiom>&apos;Chemically Induced Urinary Tract Toxicity&apos; SubClassOf &apos;Urinary Tract Toxicity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35575</classIRI>
<classLabel>Chemically Induced Irreversible Toxicity</classLabel>
<newAxiom>&apos;Chemically Induced Irreversible Toxicity&apos; SubClassOf &apos;Irreversible Toxicity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35569</classIRI>
<classLabel>Chemically Induced Cardiotoxicity</classLabel>
<newAxiom>&apos;Chemically Induced Cardiotoxicity&apos; SubClassOf &apos;Cardiotoxicity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35500</classIRI>
<classLabel>Chemically Induced Toxicity</classLabel>
<deletedAxiom>&apos;Chemically Induced Toxicity&apos; SubClassOf &apos;Biological Effect of Chemicals&apos;</deletedAxiom>
<newAxiom>&apos;Chemically Induced Toxicity&apos; SubClassOf &apos;Toxicity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163648</classIRI>
<classLabel>Diisopropyl Fluorophosphate</classLabel>
<deletedAxiom>&apos;Diisopropyl Fluorophosphate&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Diisopropyl Fluorophosphate&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163646</classIRI>
<classLabel>Diazinon</classLabel>
<deletedAxiom>&apos;Diazinon&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Diazinon&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2948</classIRI>
<classLabel>Choriocarcinoma</classLabel>
<deletedAxiom>&apos;Choriocarcinoma&apos; EquivalentTo &apos;Trophoblastic Tumor&apos; and &apos;Malignant Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Cytotrophoblastic Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Syncytiotrophoblastic Giant Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Intermediate Type Trophoblastic Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Human Chorionic Gonadotropin-Positive Neoplastic Cells Present&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Hemorrhage&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Necrotic Change&apos;)</deletedAxiom>
<newAxiom>&apos;Choriocarcinoma&apos; EquivalentTo &apos;Carcinoma&apos; and &apos;Trophoblastic Tumor&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Cytotrophoblastic Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Syncytiotrophoblastic Giant Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Intermediate Type Trophoblastic Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Human Chorionic Gonadotropin-Positive Neoplastic Cells Present&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Hemorrhage&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Necrotic Change&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163708</classIRI>
<classLabel>Tetrachlorvinphos</classLabel>
<deletedAxiom>&apos;Tetrachlorvinphos&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Tetrachlorvinphos&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35711</classIRI>
<classLabel>Testicular Teratoma with Somatic-Type Malignancy</classLabel>
<deletedAxiom>&apos;Testicular Teratoma with Somatic-Type Malignancy&apos; EquivalentTo &apos;Testicular Teratoma&apos; and &apos;Teratoma with Somatic-Type Malignancy&apos; and &apos;Malignant Testicular Non-Seminomatous Germ Cell Tumor&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Sarcomatous or Carcinomatous Component Present&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;i(12p)&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 12p&apos;)</deletedAxiom>
<newAxiom>&apos;Testicular Teratoma with Somatic-Type Malignancy&apos; EquivalentTo &apos;Testicular Teratoma&apos; and &apos;Teratoma with Somatic-Type Malignancy&apos; and &apos;Malignant Testicular Non-Seminomatous Germ Cell Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21120</classIRI>
<classLabel>Visual Analog Pain Scale</classLabel>
<newAxiom>&apos;Visual Analog Pain Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C60876</classIRI>
<classLabel>Ectopic Thyroid Tissue Present</classLabel>
<deletedAxiom>&apos;Ectopic Thyroid Tissue Present&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Ectopic Thyroid Tissue Present&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35882</classIRI>
<classLabel>Hereditary Elliptocytosis</classLabel>
<deletedAxiom>&apos;Hereditary Elliptocytosis&apos; SubClassOf &apos;Disease_Has_Finding&apos; some &apos;Hereditary Lesion&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21270</classIRI>
<classLabel>Ontology</classLabel>
<deletedAxiom>&apos;Ontology&apos; SubClassOf &apos;Terminology Entity&apos;</deletedAxiom>
<newAxiom>&apos;Ontology&apos; SubClassOf &apos;Terminology&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94540</classIRI>
<classLabel>Anterior Pituitary Gland Endocrine Neoplasm</classLabel>
<deletedAxiom>&apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21619</classIRI>
<classLabel>Mouse Mesothelioma</classLabel>
<deletedAxiom>&apos;Mouse Mesothelioma&apos; SubClassOf &apos;EO_Disease_Maps_To_Human_Disease&apos; some &apos;Mesothelioma&apos;</deletedAxiom>
<newAxiom>&apos;Mouse Mesothelioma&apos; SubClassOf &apos;EO_Disease_Maps_To_Human_Disease&apos; some &apos;Mesothelial Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104053</classIRI>
<classLabel>CTSG Gene</classLabel>
<deletedAxiom>&apos;CTSG Gene&apos; SubClassOf &apos;Cysteine Peptidase Gene&apos;</deletedAxiom>
<newAxiom>&apos;CTSG Gene&apos; SubClassOf &apos;Peptidase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104056</classIRI>
<classLabel>Cathepsin G</classLabel>
<newAxiom>&apos;Cathepsin G&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Serine Protease&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104146</classIRI>
<classLabel>CYP24A1 Gene</classLabel>
<newAxiom>&apos;CYP24A1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Intermediary Metabolic Process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104147</classIRI>
<classLabel>CYP24A1 wt Allele</classLabel>
<newAxiom>&apos;CYP24A1 wt Allele&apos; SubClassOf &apos;Gene_Is_Element_In_Pathway&apos; some &apos;Sterol Biosynthesis Pathway&apos;</newAxiom>
<newAxiom>&apos;CYP24A1 wt Allele&apos; SubClassOf &apos;Gene_In_Chromosomal_Location&apos; some &apos;20q13.2&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104148</classIRI>
<classLabel>1,25-Dihydroxyvitamin D(3) 24-Hydroxylase, Mitochondrial</classLabel>
<deletedAxiom>&apos;1,25-Dihydroxyvitamin D(3) 24-Hydroxylase, Mitochondrial&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP24A1 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;1,25-Dihydroxyvitamin D(3) 24-Hydroxylase, Mitochondrial&apos; SubClassOf &apos;Cytochrome P450&apos;</deletedAxiom>
<newAxiom>&apos;1,25-Dihydroxyvitamin D(3) 24-Hydroxylase, Mitochondrial&apos; EquivalentTo &apos;Cytochrome P450&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Sterol Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Inner Mitochondrial Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intermediary Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CYP24A1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5536</classIRI>
<classLabel>Prostate Squamous Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Prostate Squamous Cell Carcinoma&apos; EquivalentTo &apos;Squamous Cell Carcinoma&apos; and &apos;Invasive Prostate Carcinoma&apos; and (&apos;Disease_May_Have_Finding&apos; some &apos;Hematuria&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Urinary Retention&apos;)</deletedAxiom>
<newAxiom>&apos;Prostate Squamous Cell Carcinoma&apos; EquivalentTo &apos;Squamous Cell Carcinoma&apos; and &apos;Invasive Prostate Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5541</classIRI>
<classLabel>High Grade Prostatic Intraepithelial Neoplasia</classLabel>
<deletedAxiom>&apos;High Grade Prostatic Intraepithelial Neoplasia&apos; EquivalentTo &apos;Prostatic Intraepithelial Neoplasia&apos; and &apos;High Grade Glandular Intraepithelial Neoplasia&apos;</deletedAxiom>
<newAxiom>&apos;High Grade Prostatic Intraepithelial Neoplasia&apos; EquivalentTo &apos;Prostatic Intraepithelial Neoplasia&apos; and &apos;High Grade Glandular Intraepithelial Neoplasia&apos; and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;MYC Gene Amplification&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;PTEN Gene Inactivation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;TMPRSS2-ERG Fusion Protein Expression&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16258</classIRI>
<classLabel>Actin</classLabel>
<newAxiom>&apos;Actin&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ATP Hydrolysis&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5449</classIRI>
<classLabel>Central Nervous System Mesenchymal, Non-Meningothelial Neoplasm</classLabel>
<deletedAxiom>&apos;Central Nervous System Mesenchymal, Non-Meningothelial Neoplasm&apos; EquivalentTo &apos;Primary Central Nervous System Neoplasm&apos; and &apos;Soft Tissue Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Central Nervous System Mesenchymal, Non-Meningothelial Neoplasm&apos; EquivalentTo &apos;Primary Central Nervous System Neoplasm&apos; and &apos;Soft Tissue Neoplasm&apos; and (&apos;Disease_Excludes_Primary_Anatomic_Site&apos; some &apos;Lung&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200</classIRI>
<classLabel>ACC/AHA Cardiovascular and Noncardiovascular Complications of COVID-19 Terminology</classLabel>
<newAxiom>&apos;ACC/AHA Cardiovascular and Noncardiovascular Complications of COVID-19 Terminology&apos; SubClassOf &apos;COVID-19 Terminology&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80933</classIRI>
<classLabel>Hydroxyethylpiperazine Ethane Sulfonic Acid</classLabel>
<newAxiom>&apos;Hydroxyethylpiperazine Ethane Sulfonic Acid&apos; SubClassOf &apos;Buffer&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5351</classIRI>
<classLabel>Metastatic Jugulotympanic Paraganglioma</classLabel>
<deletedAxiom>&apos;Metastatic Jugulotympanic Paraganglioma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Jugulotympanic Paraganglioma&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5277</classIRI>
<classLabel>Primary Cutaneous Meningioma</classLabel>
<deletedAxiom>&apos;Primary Cutaneous Meningioma&apos; EquivalentTo &apos;Dermal Neoplasm&apos; and &apos;Ectopic Meningioma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Primary Lesion&apos;)</deletedAxiom>
<newAxiom>&apos;Primary Cutaneous Meningioma&apos; EquivalentTo &apos;Skin Soft Tissue Neoplasm&apos; and &apos;Dermal Neoplasm&apos; and &apos;Ectopic Meningioma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Primary Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5276</classIRI>
<classLabel>Primary Lung Meningioma</classLabel>
<deletedAxiom>&apos;Primary Lung Meningioma&apos; EquivalentTo &apos;Ectopic Meningioma&apos; and &apos;Lung Meningioma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Lung&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Lung Tissue&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Primary Lesion&apos;)</deletedAxiom>
<newAxiom>&apos;Primary Lung Meningioma&apos; EquivalentTo &apos;Lung Soft Tissue Neoplasm&apos; and &apos;Ectopic Meningioma&apos; and &apos;Lung Meningioma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Primary Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5238</classIRI>
<classLabel>Ovarian Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Ovarian Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Ovarian Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Ovarian Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Ovarian Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C171719</classIRI>
<classLabel>Bictegravir</classLabel>
<deletedAxiom>&apos;Bictegravir&apos; SubClassOf &apos;Anti-HIV Agent&apos;</deletedAxiom>
<newAxiom>&apos;Bictegravir&apos; SubClassOf &apos;HIV Integrase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C171500</classIRI>
<classLabel>Bilevel Positive Airway Pressure Ventilation</classLabel>
<deletedAxiom>&apos;Bilevel Positive Airway Pressure Ventilation&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Bilevel Positive Airway Pressure Ventilation&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C171576</classIRI>
<classLabel>Aggressive Variant Prostate Carcinoma</classLabel>
<deletedAxiom>&apos;Aggressive Variant Prostate Carcinoma&apos; EquivalentTo &apos;Castration-Resistant Prostate Carcinoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Aggressive Clinical Course&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Unfavorable Clinical Outcome&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Mixed Malignant Epithelial Cell Population&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Poorly Differentiated Lesion&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Neuroendocrine Differentiation&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Small Cell Component Present&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;RB1 Gene Inactivation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;TP53 Gene Inactivation&apos;)</deletedAxiom>
<newAxiom>&apos;Aggressive Variant Prostate Carcinoma&apos; EquivalentTo &apos;Castration-Resistant Prostate Carcinoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Aggressive Clinical Course&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Unfavorable Clinical Outcome&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Mixed Malignant Epithelial Cell Population&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Poorly Differentiated Lesion&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Neuroendocrine Differentiation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;RB1 Gene Inactivation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;TP53 Gene Inactivation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112501</classIRI>
<classLabel>DGKA Gene</classLabel>
<deletedAxiom>&apos;DGKA Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Phosphorylation Process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61566</classIRI>
<classLabel>Tubulin Binding Agent TTI-237</classLabel>
<deletedAxiom>&apos;Tubulin Binding Agent TTI-237&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Tubulin Binding Agent TTI-237&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36799</classIRI>
<classLabel>Abnormal Trophoblastic Cell</classLabel>
<deletedAxiom>&apos;Abnormal Trophoblastic Cell&apos; SubClassOf &apos;Abnormal Cell&apos;</deletedAxiom>
<newAxiom>&apos;Abnormal Trophoblastic Cell&apos; SubClassOf &apos;Abnormal Epithelial Cell&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C147027</classIRI>
<classLabel>Anti-DLL3/CD3 BiTE Antibody AMG 757</classLabel>
<deletedAxiom>&apos;Anti-DLL3/CD3 BiTE Antibody AMG 757&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-DLL3/CD3 BiTE Antibody AMG 757&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C147026</classIRI>
<classLabel>Anti-CD33/CD3 BiTE Antibody AMG 673</classLabel>
<deletedAxiom>&apos;Anti-CD33/CD3 BiTE Antibody AMG 673&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-CD33/CD3 BiTE Antibody AMG 673&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36803</classIRI>
<classLabel>Neoplastic Trophoblastic Cell</classLabel>
<deletedAxiom>&apos;Neoplastic Trophoblastic Cell&apos; SubClassOf &apos;Neoplastic Cell&apos;</deletedAxiom>
<newAxiom>&apos;Neoplastic Trophoblastic Cell&apos; SubClassOf &apos;Neoplastic Epithelial Cell&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C147098</classIRI>
<classLabel>Pericardial Sarcoma</classLabel>
<deletedAxiom>&apos;Pericardial Sarcoma&apos; EquivalentTo &apos;Malignant Pericardial Neoplasm&apos; and &apos;Soft Tissue Sarcoma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Pericardial Cavity&apos;)</deletedAxiom>
<newAxiom>&apos;Pericardial Sarcoma&apos; EquivalentTo &apos;Malignant Pericardial Neoplasm&apos; and &apos;Soft Tissue Sarcoma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Pericardial Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Pericardium&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172056</classIRI>
<classLabel>Boserolimab</classLabel>
<deletedAxiom>&apos;Boserolimab&apos; SubClassOf &apos;Monoclonal Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Boserolimab&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192186</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186378</classIRI>
<classLabel>Sunitinib Regimen</classLabel>
<deletedAxiom>&apos;Sunitinib Regimen&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Sunitinib Regimen&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95405</classIRI>
<classLabel>Digestive System Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and &apos;Digestive System Neuroendocrine Neoplasm&apos; and &apos;Digestive System Carcinoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Poorly Differentiated Neuroendocrine Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Severe Cytologic Atypia&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;High Grade&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 3&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Low Mitotic Activity&apos;)</deletedAxiom>
<newAxiom>&apos;Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Digestive System Neuroendocrine Neoplasm&apos; and &apos;Digestive System Carcinoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Poorly Differentiated Neuroendocrine Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Severe Cytologic Atypia&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;High Grade&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 3&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Low Mitotic Activity&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C127828</classIRI>
<classLabel>Sialocele</classLabel>
<deletedAxiom>&apos;Sialocele&apos; SubClassOf &apos;Congenital or Acquired Anatomic Abnormality&apos;</deletedAxiom>
<newAxiom>&apos;Sialocele&apos; SubClassOf &apos;Finding by Cause&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C127771</classIRI>
<classLabel>Tumor Cell to Total Cell Ratio Measurement</classLabel>
<deletedAxiom>&apos;Tumor Cell to Total Cell Ratio Measurement&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Tumor Cell to Total Cell Ratio Measurement&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95749</classIRI>
<classLabel>Gastric Choriocarcinoma</classLabel>
<deletedAxiom>&apos;Gastric Choriocarcinoma&apos; EquivalentTo &apos;Choriocarcinoma&apos; and &apos;Malignant Gastric Germ Cell Tumor&apos; and &apos;Malignant Extragonadal Nongerminomatous Germ Cell Tumor&apos;</deletedAxiom>
<newAxiom>&apos;Gastric Choriocarcinoma&apos; EquivalentTo &apos;Choriocarcinoma&apos; and &apos;Gastric Carcinoma&apos; and &apos;Malignant Gastric Germ Cell Tumor&apos; and &apos;Malignant Extragonadal Nongerminomatous Germ Cell Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C152108</classIRI>
<classLabel>Sontuzumab</classLabel>
<deletedAxiom>&apos;Sontuzumab&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Sontuzumab&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191852</classIRI>
<classLabel>Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; and &apos;Metastatic Small Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; and &apos;Metastatic Small Cell Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191981</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191855</classIRI>
<classLabel>Unresectable Extrapulmonary Small Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Unresectable Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; and &apos;Unresectable Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Unresectable Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191980 and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192014</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191854</classIRI>
<classLabel>Refractory Extrapulmonary Small Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Refractory Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; and &apos;Refractory Small Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Refractory Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; and &apos;Refractory Small Cell Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191979</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191801</classIRI>
<classLabel>PANK2 Gene</classLabel>
<deletedAxiom>&apos;PANK2 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Phosphorylation Process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6384</classIRI>
<classLabel>Paratesticular Lipoma</classLabel>
<deletedAxiom>&apos;Paratesticular Lipoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Lipoma&apos; and &apos;Benign Soft Tissue Neoplasm&apos; and &apos;Benign Male Reproductive System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Lipoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140 and &apos;Lipoma&apos; and &apos;Benign Soft Tissue Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6356</classIRI>
<classLabel>Testicular Leydig Cell Tumor</classLabel>
<deletedAxiom>&apos;Testicular Leydig Cell Tumor&apos; EquivalentTo &apos;Leydig Cell Tumor&apos; and &apos;Testicular Sex Cord-Stromal Tumor&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Leydig Cell&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Erectile Dysfunction&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Painless Testicular Mass&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Gynecomastia&apos;)</deletedAxiom>
<newAxiom>&apos;Testicular Leydig Cell Tumor&apos; EquivalentTo &apos;Leydig Cell Tumor&apos; and &apos;Testicular Sex Cord-Stromal Tumor&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Leydig Cell&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 9&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 8&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome X&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 16&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Erectile Dysfunction&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Painless Testicular Mass&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Gynecomastia&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6360</classIRI>
<classLabel>Testicular Neuroendocrine Tumor G1</classLabel>
<deletedAxiom>&apos;Testicular Neuroendocrine Tumor G1&apos; EquivalentTo &apos;Carcinoid Tumor&apos; and &apos;Testicular Neoplasm&apos; and (&apos;Disease_Is_Grade&apos; some &apos;Grade 1&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Trabecular Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Organoid Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Rosette Formation&apos;)</deletedAxiom>
<newAxiom>&apos;Testicular Neuroendocrine Tumor G1&apos; EquivalentTo &apos;Neuroendocrine Tumor&apos; and &apos;Testicular Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Prepubertal-Type Lesion&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Trabecular Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Organoid Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Rosette Formation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17488</classIRI>
<classLabel>Monocyte Differentiation Antigen CD14</classLabel>
<deletedAxiom>&apos;Monocyte Differentiation Antigen CD14&apos; EquivalentTo &apos;Cell Adhesion Molecule&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Cluster of Differentiation&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Monocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Macrophage&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phagocytosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CD14 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Monocyte Differentiation Antigen CD14&apos; EquivalentTo &apos;Cell Adhesion Molecule&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191970 and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Beta-Catenin Accumulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Salmonella Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Toll-Like Receptor Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Actin Cytoskeleton Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hematopoietic Cell Lineage Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Pathogenic Escherichia coli Infection Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amoebiasis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Phagocytosis Pathway&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Cluster of Differentiation&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Glycoprotein&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Monocyte&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Macrophage&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Phagocytosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CD14 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179530</classIRI>
<classLabel>OS Echocardiogram Table</classLabel>
<deletedAxiom>&apos;OS Echocardiogram Table&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;OS Echocardiogram Table&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179562</classIRI>
<classLabel>Peritoneal Low Grade Endometrioid Stromal Sarcoma</classLabel>
<deletedAxiom>&apos;Peritoneal Low Grade Endometrioid Stromal Sarcoma&apos; EquivalentTo &apos;Malignant Peritoneal Neoplasm&apos; and &apos;Low Grade Endometrioid Stromal Sarcoma&apos;</deletedAxiom>
<newAxiom>&apos;Peritoneal Low Grade Endometrioid Stromal Sarcoma&apos; EquivalentTo &apos;Malignant Peritoneal Neoplasm&apos; and &apos;Low Grade Endometrioid Stromal Sarcoma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneal Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Peritoneum&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4009</classIRI>
<classLabel>Non-Functioning Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;Non-Functioning Pituitary Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Non-Functioning Pituitary Gland Neoplasm&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
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<classLabel>Fluorine F18 T807</classLabel>
<deletedAxiom>&apos;Fluorine F18 T807&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Fluorine F18 T807&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
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<classLabel>BiTE Antibody AMG 910</classLabel>
<deletedAxiom>&apos;BiTE Antibody AMG 910&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;BiTE Antibody AMG 910&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
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<classLabel>Anti-amyloid Monoclonal Antibody NEOD001</classLabel>
<deletedAxiom>&apos;Anti-amyloid Monoclonal Antibody NEOD001&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-amyloid Monoclonal Antibody NEOD001&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
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<changedClass>
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<classLabel>c-Met Inhibitor MSC2156119J</classLabel>
<deletedAxiom>&apos;c-Met Inhibitor MSC2156119J&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;c-Met Inhibitor MSC2156119J&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4646</classIRI>
<classLabel>Gestational Choriocarcinoma</classLabel>
<deletedAxiom>&apos;Gestational Choriocarcinoma&apos; EquivalentTo &apos;Choriocarcinoma&apos; and &apos;Gestational Trophoblastic Tumor&apos; and &apos;Malignant Female Reproductive System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Gestational Choriocarcinoma&apos; EquivalentTo &apos;Female Reproductive System Carcinoma&apos; and &apos;Choriocarcinoma&apos; and &apos;Gestational Trophoblastic Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4515</classIRI>
<classLabel>Ovarian Choriocarcinoma</classLabel>
<deletedAxiom>&apos;Ovarian Choriocarcinoma&apos; EquivalentTo &apos;Choriocarcinoma&apos; and &apos;Malignant Ovarian Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Ovary&apos;)</deletedAxiom>
<newAxiom>&apos;Ovarian Choriocarcinoma&apos; EquivalentTo &apos;Choriocarcinoma&apos; and &apos;Ovarian Carcinoma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Ovary&apos;)</newAxiom>
</changedClass>
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<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131179</classIRI>
<classLabel>MET Exon 14 Skipping Mutation</classLabel>
<deletedAxiom>&apos;MET Exon 14 Skipping Mutation&apos; SubClassOf &apos;Splice-Site Mutation&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4456</classIRI>
<classLabel>Malignant Mesothelioma</classLabel>
<deletedAxiom>&apos;Malignant Mesothelioma&apos; EquivalentTo &apos;Mesothelioma&apos; and &apos;Malignant Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Mesothelial Cell&apos;)</deletedAxiom>
<newAxiom>&apos;Malignant Mesothelioma&apos; EquivalentTo &apos;Mesothelial Neoplasm&apos; and &apos;Malignant Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Mesothelial Cell&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4462</classIRI>
<classLabel>Skin Squamous Papilloma</classLabel>
<deletedAxiom>&apos;Skin Squamous Papilloma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Skin Squamous Papilloma&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C170437</classIRI>
<classLabel>Peroxisomal Acyl-CoA Oxidase Deficiency</classLabel>
<newAxiom>&apos;Peroxisomal Acyl-CoA Oxidase Deficiency&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191889</newAxiom>
</changedClass>
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<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76493</classIRI>
<classLabel>Elvitegravir</classLabel>
<deletedAxiom>&apos;Elvitegravir&apos; SubClassOf &apos;Antiviral Agent&apos;</deletedAxiom>
<newAxiom>&apos;Elvitegravir&apos; SubClassOf &apos;HIV Integrase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4289</classIRI>
<classLabel>Teratoma with Somatic-Type Malignancy</classLabel>
<deletedAxiom>&apos;Teratoma with Somatic-Type Malignancy&apos; EquivalentTo &apos;Teratoma&apos; and (&apos;Disease_Has_Cytogenetic_Abnormality&apos; some &apos;i(12p)&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Malignant Component Present&apos;) and (&apos;Disease_Has_Associated_Disease&apos; some &apos;Somatic-Type Malignancy&apos;)</deletedAxiom>
<newAxiom>&apos;Teratoma with Somatic-Type Malignancy&apos; EquivalentTo &apos;Teratoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Malignant Component Present&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;i(12p)&apos;) and (&apos;Disease_Has_Associated_Disease&apos; some &apos;Somatic-Type Malignancy&apos;)</newAxiom>
</changedClass>
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<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111874</classIRI>
<classLabel>5-Aminolevulinate Synthase, Nonspecific, Mitochondrial</classLabel>
<deletedAxiom>&apos;5-Aminolevulinate Synthase, Nonspecific, Mitochondrial&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycine, Serine and Threonine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Porphyrin and Chlorophyll Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hemoglobin Chaperone Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA2 and FOXA3 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrial Matrix&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALAS1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;5-Aminolevulinate Synthase, Nonspecific, Mitochondrial&apos; EquivalentTo &apos;Acyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glycine, Serine and Threonine Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Porphyrin and Chlorophyll Metabolism Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hemoglobin Chaperone Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA2 and FOXA3 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Mitochondrial Matrix&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Biosynthetic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ALAS1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111872</classIRI>
<classLabel>ALAS1 Gene</classLabel>
<newAxiom>&apos;ALAS1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Biosynthetic Process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C184764</classIRI>
<classLabel>IGF-1R Inhibition</classLabel>
<newAxiom>&apos;IGF-1R Inhibition&apos; SubClassOf &apos;Targeted Molecular Therapy&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37155</classIRI>
<classLabel>Neoplastic Meningothelial Cell</classLabel>
<deletedAxiom>&apos;Neoplastic Meningothelial Cell&apos; SubClassOf &apos;Neoplastic Cell&apos;</deletedAxiom>
<newAxiom>&apos;Neoplastic Meningothelial Cell&apos; SubClassOf &apos;Neoplastic Connective and Soft Tissue Cell&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111988</classIRI>
<classLabel>FGFR Inhibitor Debio 1347</classLabel>
<deletedAxiom>&apos;FGFR Inhibitor Debio 1347&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;FGFR Inhibitor Debio 1347&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111995</classIRI>
<classLabel>Anti-SLITRK6 Monoclonal Antibody-MMAE Conjugate AGS15E</classLabel>
<deletedAxiom>&apos;Anti-SLITRK6 Monoclonal Antibody-MMAE Conjugate AGS15E&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-SLITRK6 Monoclonal Antibody-MMAE Conjugate AGS15E&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159998</classIRI>
<classLabel>Bevacizumab Regimen</classLabel>
<newAxiom>&apos;Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Sarcoma&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Ovarian Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Cervical Carcinoma&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Fallopian Tube Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Renal Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Central Nervous System Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Peritoneal Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Reproductive Endocrine Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Endometrial Carcinoma&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Soft Tissue Neoplasm&apos;</newAxiom>
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<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C170296</classIRI>
<classLabel>Pegcetacoplan</classLabel>
<deletedAxiom>&apos;Pegcetacoplan&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Pegcetacoplan&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159609</classIRI>
<classLabel>Anti-CEACAM6 Antibody BAY1834942</classLabel>
<deletedAxiom>&apos;Anti-CEACAM6 Antibody BAY1834942&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-CEACAM6 Antibody BAY1834942&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4743</classIRI>
<classLabel>Benign Basal Cell Neoplasm</classLabel>
<deletedAxiom>&apos;Benign Basal Cell Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Benign Basal Cell Neoplasm&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C184627</classIRI>
<classLabel>Methylphenobarbital Measurement</classLabel>
<deletedAxiom>&apos;Methylphenobarbital Measurement&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Methylphenobarbital Measurement&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159507</classIRI>
<classLabel>Primary Peritoneal Carcinosarcoma</classLabel>
<deletedAxiom>&apos;Primary Peritoneal Carcinosarcoma&apos; EquivalentTo &apos;Malignant Peritoneal Neoplasm&apos; and &apos;Malignant Mixed Mesodermal (Mullerian) Tumor&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneum&apos;)</deletedAxiom>
<newAxiom>&apos;Primary Peritoneal Carcinosarcoma&apos; EquivalentTo &apos;Malignant Peritoneal Neoplasm&apos; and &apos;Malignant Mixed Mesodermal (Mullerian) Tumor&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneal Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Peritoneum&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159171</classIRI>
<classLabel>Someone There to Confide in or Talk About Yourself or Your Problems</classLabel>
<deletedAxiom>&apos;Someone There to Confide in or Talk About Yourself or Your Problems&apos; SubClassOf &apos;Someone There&apos;</deletedAxiom>
<newAxiom>&apos;Someone There to Confide in or Talk About Yourself or Your Problems&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159224</classIRI>
<classLabel>Kidney Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Kidney Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Kidney Neuroendocrine Neoplasm&apos; and &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and &apos;Kidney Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Kidney Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Kidney Neuroendocrine Neoplasm&apos; and &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Kidney Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159225</classIRI>
<classLabel>Kidney Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Kidney Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Kidney Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Kidney Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Kidney Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159200</classIRI>
<classLabel>BCL-2 Inhibitor</classLabel>
<deletedAxiom>&apos;BCL-2 Inhibitor&apos; SubClassOf &apos;Apoptotic Pathway-targeting Antineoplastic Agent&apos;</deletedAxiom>
<newAxiom>&apos;BCL-2 Inhibitor&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192025</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185247</classIRI>
<classLabel>Nucleotide Sequencing Read Quality Control Data</classLabel>
<deletedAxiom>&apos;Nucleotide Sequencing Read Quality Control Data&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Nucleotide Sequencing Read Quality Control Data&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96443</classIRI>
<classLabel>Peroxisomal Acyl-Coenzyme A Oxidase 2</classLabel>
<deletedAxiom>&apos;Peroxisomal Acyl-Coenzyme A Oxidase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Peroxisome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Oxidation/Reduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACOX2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Peroxisomal Acyl-Coenzyme A Oxidase 2&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Peroxisome&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACOX2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96442</classIRI>
<classLabel>ACOX2 wt Allele</classLabel>
<deletedAxiom>&apos;ACOX2 wt Allele&apos; SubClassOf &apos;Gene_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;</deletedAxiom>
<deletedAxiom>&apos;ACOX2 wt Allele&apos; SubClassOf &apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;</deletedAxiom>
<deletedAxiom>&apos;ACOX2 wt Allele&apos; SubClassOf &apos;Gene_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;</deletedAxiom>
<deletedAxiom>&apos;ACOX2 wt Allele&apos; SubClassOf &apos;ACOX2 Gene&apos;</deletedAxiom>
<newAxiom>&apos;ACOX2 wt Allele&apos; EquivalentTo &apos;ACOX2 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Bile Acid Biosynthesis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Peroxisome Biogenesis Pathway&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185326</classIRI>
<classLabel>Central Review</classLabel>
<deletedAxiom>&apos;Central Review&apos; SubClassOf &apos;Review&apos;</deletedAxiom>
<newAxiom>&apos;Central Review&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191951</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112056</classIRI>
<classLabel>Dynein Axonemal Intermediate Chain 7</classLabel>
<deletedAxiom>&apos;Dynein Axonemal Intermediate Chain 7&apos; SubClassOf &apos;Cytoskeletal Protein&apos;</deletedAxiom>
<newAxiom>&apos;Dynein Axonemal Intermediate Chain 7&apos; SubClassOf &apos;Microtubule Associated Protein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96566</classIRI>
<classLabel>Average Metabolic Standard Uptake Value</classLabel>
<deletedAxiom>&apos;Average Metabolic Standard Uptake Value&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Average Metabolic Standard Uptake Value&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126772</classIRI>
<classLabel>Endometrial Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Endometrial Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Endometrial Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Endometrial Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Endometrial Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
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<classLabel>VLP-encapsulated TLR9 Agonist CMP-001</classLabel>
<deletedAxiom>&apos;VLP-encapsulated TLR9 Agonist CMP-001&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;VLP-encapsulated TLR9 Agonist CMP-001&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126273</classIRI>
<classLabel>Diphtheria Toxin Fragment-Interleukin-2 Fusion Protein E7777</classLabel>
<deletedAxiom>&apos;Diphtheria Toxin Fragment-Interleukin-2 Fusion Protein E7777&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Diphtheria Toxin Fragment-Interleukin-2 Fusion Protein E7777&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
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<changedClass>
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<classLabel>Androgen Receptor Antagonist SHR3680</classLabel>
<deletedAxiom>&apos;Androgen Receptor Antagonist SHR3680&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Androgen Receptor Antagonist SHR3680&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126356</classIRI>
<classLabel>Peritoneal Desmoplastic Small Round Cell Tumor</classLabel>
<deletedAxiom>&apos;Peritoneal Desmoplastic Small Round Cell Tumor&apos; EquivalentTo &apos;Malignant Peritoneal Neoplasm&apos; and &apos;Desmoplastic Small Round Cell Tumor&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneum&apos;)</deletedAxiom>
<newAxiom>&apos;Peritoneal Desmoplastic Small Round Cell Tumor&apos; EquivalentTo &apos;Malignant Peritoneal Neoplasm&apos; and &apos;Desmoplastic Small Round Cell Tumor&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneal Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Peritoneum&apos;)</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126357</classIRI>
<classLabel>Peritoneal Solitary Fibrous Tumor</classLabel>
<deletedAxiom>&apos;Peritoneal Solitary Fibrous Tumor&apos; EquivalentTo &apos;Peritoneal Neoplasm&apos; and &apos;Solitary Fibrous Tumor&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneum&apos;)</deletedAxiom>
<newAxiom>&apos;Peritoneal Solitary Fibrous Tumor&apos; EquivalentTo &apos;Peritoneal Neoplasm&apos; and &apos;Solitary Fibrous Tumor&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneal Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Peritoneum&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C190730</classIRI>
<classLabel>HER2-targeted Therapy</classLabel>
<deletedAxiom>&apos;HER2-targeted Therapy&apos; SubClassOf &apos;Targeted Therapy&apos;</deletedAxiom>
<newAxiom>&apos;HER2-targeted Therapy&apos; SubClassOf &apos;Targeted Molecular Therapy&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165738</classIRI>
<classLabel>Locally Advanced Merkel Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Locally Advanced Merkel Cell Carcinoma&apos; EquivalentTo &apos;Locally Advanced Neuroendocrine Carcinoma&apos; and &apos;Metastatic Merkel Cell Carcinoma&apos; and &apos;Locally Advanced Malignant Skin Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Locally Advanced Merkel Cell Carcinoma&apos; EquivalentTo &apos;Metastatic Merkel Cell Carcinoma&apos; and &apos;Locally Advanced Malignant Skin Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191983</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165741</classIRI>
<classLabel>Refractory Merkel Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Refractory Merkel Cell Carcinoma&apos; EquivalentTo &apos;Refractory Malignant Skin Neoplasm&apos; and &apos;Refractory Neuroendocrine Carcinoma&apos; and &apos;Merkel Cell Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Refractory Merkel Cell Carcinoma&apos; EquivalentTo &apos;Refractory Malignant Skin Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191979 and &apos;Merkel Cell Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C190424</classIRI>
<classLabel>Pociredir</classLabel>
<deletedAxiom>&apos;Pociredir&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Pociredir&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C190417</classIRI>
<classLabel>Freneslerbart</classLabel>
<deletedAxiom>&apos;Freneslerbart&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Freneslerbart&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C190403</classIRI>
<classLabel>AK1 Gene</classLabel>
<deletedAxiom>&apos;AK1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Phosphorylation Process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82856</classIRI>
<classLabel>SIRT6 wt Allele</classLabel>
<newAxiom>&apos;SIRT6 wt Allele&apos; SubClassOf &apos;Gene_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82855</classIRI>
<classLabel>SIRT6 Gene</classLabel>
<deletedAxiom>&apos;SIRT6 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Protein Glycosylation&apos;</deletedAxiom>
<newAxiom>&apos;SIRT6 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Nucleotide Metabolic Process&apos;</newAxiom>
<newAxiom>&apos;SIRT6 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Post-Translational Modification&apos;</newAxiom>
<newAxiom>&apos;SIRT6 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;ADP Ribosylation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82857</classIRI>
<classLabel>Mono-ADP-Ribosyltransferase Sirtuin-6</classLabel>
<deletedAxiom>&apos;Mono-ADP-Ribosyltransferase Sirtuin-6&apos; SubClassOf &apos;Glycosyltransferase&apos;</deletedAxiom>
<deletedAxiom>&apos;Mono-ADP-Ribosyltransferase Sirtuin-6&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;</deletedAxiom>
<deletedAxiom>&apos;Mono-ADP-Ribosyltransferase Sirtuin-6&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SIRT6 Gene&apos;</deletedAxiom>
<newAxiom>&apos;Mono-ADP-Ribosyltransferase Sirtuin-6&apos; EquivalentTo &apos;Acyltransferase&apos; and &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;HDAC Class I Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;ADP Ribosylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Translational Modification&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SIRT6 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179863</classIRI>
<classLabel>Spastic Paraplegia 50</classLabel>
<newAxiom>&apos;Spastic Paraplegia 50&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191994</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179850</classIRI>
<classLabel>Oncotype DX Breast Cancer Recurrence Score Less than or Equal to Eighteen</classLabel>
<deletedAxiom>&apos;Oncotype DX Breast Cancer Recurrence Score Less than or Equal to Eighteen&apos; SubClassOf &apos;Decreased Expression&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165300</classIRI>
<classLabel>Advanced Merkel Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Advanced Merkel Cell Carcinoma&apos; EquivalentTo &apos;Advanced Neuroendocrine Carcinoma&apos; and &apos;Metastatic Merkel Cell Carcinoma&apos; and &apos;Advanced Malignant Skin Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Advanced Merkel Cell Carcinoma&apos; EquivalentTo &apos;Metastatic Merkel Cell Carcinoma&apos; and &apos;Advanced Malignant Skin Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191982</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43520</classIRI>
<classLabel>Gene Ontology</classLabel>
<deletedAxiom>&apos;Gene Ontology&apos; SubClassOf &apos;Information Resource&apos;</deletedAxiom>
<newAxiom>&apos;Gene Ontology&apos; SubClassOf &apos;Ontology&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106624</classIRI>
<classLabel>Visual Analogue Fatigue Scale</classLabel>
<newAxiom>&apos;Visual Analogue Fatigue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C190057</classIRI>
<classLabel>CMPK2 Gene</classLabel>
<deletedAxiom>&apos;CMPK2 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Phosphorylation Process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7911</classIRI>
<classLabel>Growth Hormone-Producing Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;Growth Hormone-Producing Pituitary Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Growth Hormone-Producing Pituitary Gland Neoplasm&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7910</classIRI>
<classLabel>Prolactin-Producing Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;Prolactin-Producing Pituitary Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Prolactin-Producing Pituitary Gland Neoplasm&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7909</classIRI>
<classLabel>ACTH-Producing Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;ACTH-Producing Pituitary Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;ACTH-Producing Pituitary Gland Neoplasm&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168584</classIRI>
<classLabel>CD28/ICOS Antagonist ALPN-101</classLabel>
<deletedAxiom>&apos;CD28/ICOS Antagonist ALPN-101&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;CD28/ICOS Antagonist ALPN-101&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168543</classIRI>
<classLabel>Locally Advanced Thyroid Gland Medullary Carcinoma</classLabel>
<deletedAxiom>&apos;Locally Advanced Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Locally Advanced Neuroendocrine Carcinoma&apos; and &apos;Metastatic Thyroid Gland Medullary Carcinoma&apos; and &apos;Locally Advanced Thyroid Gland Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Locally Advanced Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Metastatic Thyroid Gland Medullary Carcinoma&apos; and &apos;Locally Advanced Thyroid Gland Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191983</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129028</classIRI>
<classLabel>Frontonasal Dysplasia</classLabel>
<newAxiom>&apos;Frontonasal Dysplasia&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191926</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168639</classIRI>
<classLabel>PQ/CMC Application Type Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Application Type Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Application Type Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7827</classIRI>
<classLabel>Metastatic Malignant Parathyroid Gland Neoplasm</classLabel>
<deletedAxiom>&apos;Metastatic Malignant Parathyroid Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Malignant Parathyroid Gland Neoplasm&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C134826</classIRI>
<classLabel>Cumulative Illness Rating Scale for Geriatrics</classLabel>
<deletedAxiom>&apos;Cumulative Illness Rating Scale for Geriatrics&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Cumulative Illness Rating Scale for Geriatrics&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38345</classIRI>
<classLabel>JUN Pathway Deregulation</classLabel>
<deletedAxiom>&apos;JUN Pathway Deregulation&apos; SubClassOf &apos;Molecular Pathway Deregulation&apos;</deletedAxiom>
<newAxiom>&apos;JUN Pathway Deregulation&apos; SubClassOf &apos;Signal Transduction Pathway Deregulation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63413</classIRI>
<classLabel>Bevacizumab/Carboplatin/Paclitaxel Regimen</classLabel>
<newAxiom>&apos;Bevacizumab/Carboplatin/Paclitaxel Regimen&apos; SubClassOf &apos;Regimen Used to Treat Cervical Carcinoma&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab/Carboplatin/Paclitaxel Regimen&apos; SubClassOf &apos;Regimen Used to Treat Endometrial Carcinoma&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab/Carboplatin/Paclitaxel Regimen&apos; SubClassOf &apos;Regimen Used to Treat Vulvar Cancer&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63410</classIRI>
<classLabel>Carboplatin/Gemcitabine Regimen</classLabel>
<newAxiom>&apos;Carboplatin/Gemcitabine Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Fallopian Tube Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Carboplatin/Gemcitabine Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Peritoneal Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C120038</classIRI>
<classLabel>Fluorescent Imaging Ligand OTL38</classLabel>
<deletedAxiom>&apos;Fluorescent Imaging Ligand OTL38&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Fluorescent Imaging Ligand OTL38&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63596</classIRI>
<classLabel>CAPOX Regimen</classLabel>
<newAxiom>&apos;CAPOX Regimen&apos; SubClassOf &apos;Regimen Used to Treat Pancreatic Carcinoma&apos;</newAxiom>
<newAxiom>&apos;CAPOX Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Neuroendocrine and Adrenal Neoplasm&apos;</newAxiom>
<newAxiom>&apos;CAPOX Regimen&apos; SubClassOf &apos;Regimen Used to Treat Esophageal Carcinoma&apos;</newAxiom>
<newAxiom>&apos;CAPOX Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Intestinal Neoplasm&apos;</newAxiom>
<newAxiom>&apos;CAPOX Regimen&apos; SubClassOf &apos;Regimen Used to Treat Gastric Carcinoma&apos;</newAxiom>
<newAxiom>&apos;CAPOX Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Ovarian Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63608</classIRI>
<classLabel>FOLFIRI-Bevacizumab Regimen</classLabel>
<newAxiom>&apos;FOLFIRI-Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Intestinal Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63609</classIRI>
<classLabel>CAPOX-Bevacizumab Regimen</classLabel>
<newAxiom>&apos;CAPOX-Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Intestinal Neoplasm&apos;</newAxiom>
<newAxiom>&apos;CAPOX-Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Ovarian Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38687</classIRI>
<classLabel>Methoxy Polyethylene Glycol-Epoetin beta</classLabel>
<deletedAxiom>&apos;Methoxy Polyethylene Glycol-Epoetin beta&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Methoxy Polyethylene Glycol-Epoetin beta&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63685</classIRI>
<classLabel>GEM/CAP Regimen</classLabel>
<newAxiom>&apos;GEM/CAP Regimen&apos; SubClassOf &apos;Regimen Used to Treat Hepatobiliary Cancer&apos;</newAxiom>
<newAxiom>&apos;GEM/CAP Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Thymus Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24259</classIRI>
<classLabel>BCL10 Gene</classLabel>
<deletedAxiom>&apos;BCL10 Gene&apos; SubClassOf &apos;Gene_Associated_With_Disease&apos; some &apos;Mesothelioma&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97225</classIRI>
<classLabel>Zinc Finger FYVE Domain-Containing Protein 19</classLabel>
<deletedAxiom>&apos;Zinc Finger FYVE Domain-Containing Protein 19&apos; SubClassOf &apos;Regulatory Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;Zinc Finger FYVE Domain-Containing Protein 19&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ZFYVE19 Gene&apos;</deletedAxiom>
<newAxiom>&apos;Zinc Finger FYVE Domain-Containing Protein 19&apos; EquivalentTo &apos;Cell Cycle Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centrosome&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Metal Binding Site&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytokinesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Checkpoint&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ZFYVE19 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97223</classIRI>
<classLabel>ZFYVE19 Gene</classLabel>
<deletedAxiom>&apos;ZFYVE19 Gene&apos; SubClassOf &apos;Regulatory Gene&apos;</deletedAxiom>
<newAxiom>&apos;ZFYVE19 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Cell Cycle Checkpoint&apos;</newAxiom>
<newAxiom>&apos;ZFYVE19 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Cytokinesis&apos;</newAxiom>
<newAxiom>&apos;ZFYVE19 Gene&apos; SubClassOf &apos;Cell Cycle Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173603</classIRI>
<classLabel>Worst Severity Past Seven Days Question</classLabel>
<newAxiom>&apos;Worst Severity Past Seven Days Question&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192060</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C148408</classIRI>
<classLabel>Dolutegravir Sodium</classLabel>
<deletedAxiom>&apos;Dolutegravir Sodium&apos; SubClassOf &apos;Antiviral Agent&apos;</deletedAxiom>
<newAxiom>&apos;Dolutegravir Sodium&apos; SubClassOf &apos;HIV Integrase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173586</classIRI>
<classLabel>Extracutaneous Merkel Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Extracutaneous Merkel Cell Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma&apos; and (&apos;Disease_Has_Associated_Anatomic_Site&apos; some &apos;Lymph Node&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Neuroendocrine Small Round Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Single Cell Necrosis&apos;) and (&apos;Disease_Excludes_Primary_Anatomic_Site&apos; some &apos;Skin&apos;)</deletedAxiom>
<newAxiom>&apos;Extracutaneous Merkel Cell Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and (&apos;Disease_Has_Associated_Anatomic_Site&apos; some &apos;Lymph Node&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Neuroendocrine Small Round Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Single Cell Necrosis&apos;) and (&apos;Disease_Excludes_Primary_Anatomic_Site&apos; some &apos;Skin&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C135014</classIRI>
<classLabel>Dispense Limited Quantity</classLabel>
<deletedAxiom>&apos;Dispense Limited Quantity&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Dispense Limited Quantity&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192109</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C135015</classIRI>
<classLabel>Prescribe Limited Quantity</classLabel>
<deletedAxiom>&apos;Prescribe Limited Quantity&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Prescribe Limited Quantity&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192109</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C160005</classIRI>
<classLabel>Capecitabine Regimen</classLabel>
<newAxiom>&apos;Capecitabine Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Intestinal Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Capecitabine Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Neuroendocrine and Adrenal Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Capecitabine Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Reproductive Endocrine Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Capecitabine Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Head and Neck Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101400</classIRI>
<classLabel>Uncharacterized Protein C9orf72</classLabel>
<deletedAxiom>&apos;Uncharacterized Protein C9orf72&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;C9orf72 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;Uncharacterized Protein C9orf72&apos; SubClassOf &apos;Regulatory Protein&apos;</deletedAxiom>
<newAxiom>&apos;Uncharacterized Protein C9orf72&apos; EquivalentTo &apos;Guanine Nucleotide Exchange Factor&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Autophagy Regulation Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cellular Stress Response&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Autophagy&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;C9orf72 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101415</classIRI>
<classLabel>Single-Stranded DNA Cytosine Deaminase</classLabel>
<deletedAxiom>&apos;Single-Stranded DNA Cytosine Deaminase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymph Node Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Tonsillar Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Hydrolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Differentiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AICDA Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Single-Stranded DNA Cytosine Deaminase&apos; EquivalentTo &apos;Hydrolase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Intestinal IgA Production Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;IL4-Mediated Signaling Pathway&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Lymph Node Tissue&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Tonsillar Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nucleotide Metabolic Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Methylation Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;B-Cell Differentiation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AICDA Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101413</classIRI>
<classLabel>AICDA Gene</classLabel>
<deletedAxiom>&apos;AICDA Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Hydrolysis&apos;</deletedAxiom>
<newAxiom>&apos;AICDA Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Nucleotide Metabolic Process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101372</classIRI>
<classLabel>TIAF1 Gene</classLabel>
<deletedAxiom>&apos;TIAF1 Gene&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;TIAF1 Gene&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101373</classIRI>
<classLabel>TIAF1 wt Allele</classLabel>
<deletedAxiom>&apos;TIAF1 wt Allele&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;TIAF1 wt Allele&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101398</classIRI>
<classLabel>C9orf72 Gene</classLabel>
<deletedAxiom>&apos;C9orf72 Gene&apos; SubClassOf &apos;Regulatory Gene&apos;</deletedAxiom>
<newAxiom>&apos;C9orf72 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Autophagy&apos;</newAxiom>
<newAxiom>&apos;C9orf72 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</newAxiom>
<newAxiom>&apos;C9orf72 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Cellular Stress Response&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101399</classIRI>
<classLabel>C9orf72 wt Allele</classLabel>
<deletedAxiom>&apos;C9orf72 wt Allele&apos; SubClassOf &apos;C9orf72 Gene&apos;</deletedAxiom>
<newAxiom>&apos;C9orf72 wt Allele&apos; EquivalentTo &apos;C9orf72 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Amyotrophic Lateral Sclerosis Pathway&apos;) and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Autophagy Regulation Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;9p21.2&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8046</classIRI>
<classLabel>Metastatic Adrenal Gland Pheochromocytoma</classLabel>
<deletedAxiom>&apos;Metastatic Adrenal Gland Pheochromocytoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Adrenal Gland Pheochromocytoma&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8011</classIRI>
<classLabel>Thyrotroph Pituitary Neuroendocrine Tumor</classLabel>
<deletedAxiom>&apos;Thyrotroph Pituitary Neuroendocrine Tumor&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Thyrotroph Pituitary Neuroendocrine Tumor&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101259</classIRI>
<classLabel>Pegylated Recombinant L-asparaginase Erwinia chrysanthemi</classLabel>
<deletedAxiom>&apos;Pegylated Recombinant L-asparaginase Erwinia chrysanthemi&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Pegylated Recombinant L-asparaginase Erwinia chrysanthemi&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C188850</classIRI>
<classLabel>Workflow Item Description</classLabel>
<deletedAxiom>&apos;Workflow Item Description&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Workflow Item Description&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C188505</classIRI>
<classLabel>Islatravir Monohydrate</classLabel>
<deletedAxiom>&apos;Islatravir Monohydrate&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Islatravir Monohydrate&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174033</classIRI>
<classLabel>Primary Middle Ear Meningioma</classLabel>
<deletedAxiom>&apos;Primary Middle Ear Meningioma&apos; EquivalentTo &apos;Middle Ear Neoplasm&apos; and &apos;Ectopic Meningioma&apos;</deletedAxiom>
<newAxiom>&apos;Primary Middle Ear Meningioma&apos; EquivalentTo &apos;Middle Ear Neoplasm&apos; and &apos;Ectopic Meningioma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Middle Ear&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Primary Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8612</classIRI>
<classLabel>Benign Peritoneal Neoplasm</classLabel>
<deletedAxiom>&apos;Benign Peritoneal Neoplasm&apos; EquivalentTo &apos;Benign Peritoneal and Retroperitoneal Neoplasm&apos; and &apos;Peritoneal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneum&apos;)</deletedAxiom>
<newAxiom>&apos;Benign Peritoneal Neoplasm&apos; EquivalentTo &apos;Benign Peritoneal and Retroperitoneal Neoplasm&apos; and &apos;Peritoneal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneal Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Peritoneum&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129968</classIRI>
<classLabel>MAGE-A3 Multipeptide Vaccine GL-0817</classLabel>
<deletedAxiom>&apos;MAGE-A3 Multipeptide Vaccine GL-0817&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;MAGE-A3 Multipeptide Vaccine GL-0817&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19383</classIRI>
<classLabel>Adjuvanticity</classLabel>
<deletedAxiom>&apos;Adjuvanticity&apos; SubClassOf &apos;Chemical Properties&apos;</deletedAxiom>
<newAxiom>&apos;Adjuvanticity&apos; SubClassOf &apos;Biological Effect of Chemicals&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115440</classIRI>
<classLabel>Recurrent Merkel Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Recurrent Merkel Cell Carcinoma&apos; EquivalentTo &apos;Recurrent Neuroendocrine Carcinoma&apos; and &apos;Recurrent Skin Carcinoma&apos; and &apos;Merkel Cell Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Merkel Cell Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191978 and &apos;Recurrent Skin Carcinoma&apos; and &apos;Merkel Cell Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C140162</classIRI>
<classLabel>Personalized Cancer Vaccine RO7198457</classLabel>
<deletedAxiom>&apos;Personalized Cancer Vaccine RO7198457&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Personalized Cancer Vaccine RO7198457&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C188130</classIRI>
<classLabel>PQ/CMC Deprecated Subsets</classLabel>
<deletedAxiom>&apos;PQ/CMC Deprecated Subsets&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Deprecated Subsets&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129788</classIRI>
<classLabel>B Acute Lymphoblastic Leukemia, BCR-ABL1-Like</classLabel>
<deletedAxiom>&apos;B Acute Lymphoblastic Leukemia, BCR-ABL1-Like&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;B Acute Lymphoblastic Leukemia, BCR-ABL1-Like&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C140115</classIRI>
<classLabel>R-HyperCVAD Alternating with High-dose MTX AraC Regimen</classLabel>
<newAxiom>&apos;R-HyperCVAD Alternating with High-dose MTX AraC Regimen&apos; SubClassOf &apos;Regimen Used to Treat Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8264</classIRI>
<classLabel>Childhood Meningioma</classLabel>
<deletedAxiom>&apos;Childhood Meningioma&apos; EquivalentTo &apos;Meningioma&apos; and &apos;Childhood Central Nervous System Neoplasm&apos; and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 12q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 20q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 15q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 1q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 9q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 17q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 14&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 22&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 1p&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 3p&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;NF2 Gene Inactivation&apos;)</deletedAxiom>
<newAxiom>&apos;Childhood Meningioma&apos; EquivalentTo &apos;Childhood Connective and Soft Tissue Neoplasm&apos; and &apos;Meningioma&apos; and &apos;Childhood Central Nervous System Neoplasm&apos; and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 12q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 20q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 15q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 1q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 9q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 17q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 14&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 22&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 1p&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 3p&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;NF2 Gene Inactivation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129870</classIRI>
<classLabel>Nemaline Myopathy 3</classLabel>
<newAxiom>&apos;Nemaline Myopathy 3&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191893</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154553</classIRI>
<classLabel>SLCT Inhibitor GNS561</classLabel>
<deletedAxiom>&apos;SLCT Inhibitor GNS561&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;SLCT Inhibitor GNS561&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8955</classIRI>
<classLabel>Rete Testis Adenocarcinoma</classLabel>
<deletedAxiom>&apos;Rete Testis Adenocarcinoma&apos; EquivalentTo &apos;Male Reproductive System Carcinoma&apos; and &apos;Adenocarcinoma&apos; and &apos;Rete Testis Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Rete Testis&apos;)</deletedAxiom>
<newAxiom>&apos;Rete Testis Adenocarcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192129 and &apos;Adenocarcinoma&apos; and &apos;Rete Testis Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Rete Testis&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154617</classIRI>
<classLabel>Digestive System Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Digestive System Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Large Cell Neuroendocrine Carcinoma&apos; and &apos;Digestive System Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Digestive System Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984 and &apos;Digestive System Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154414</classIRI>
<classLabel>Human Phenotype Ontology</classLabel>
<deletedAxiom>&apos;Human Phenotype Ontology&apos; SubClassOf &apos;Information Resource&apos;</deletedAxiom>
<newAxiom>&apos;Human Phenotype Ontology&apos; SubClassOf &apos;Ontology&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6813</classIRI>
<classLabel>Prostate Ductal Adenocarcinoma</classLabel>
<deletedAxiom>&apos;Prostate Ductal Adenocarcinoma&apos; EquivalentTo &apos;Prostate Adenocarcinoma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Tall Columnar Adenocarcinoma Cell&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Urinary Frequency&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Hematuria&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Urinary Retention&apos;)</deletedAxiom>
<newAxiom>&apos;Prostate Ductal Adenocarcinoma&apos; EquivalentTo &apos;Prostate Adenocarcinoma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Tall Columnar Adenocarcinoma Cell&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78515</classIRI>
<classLabel>Pain in Extremity</classLabel>
<deletedAxiom>&apos;Pain in Extremity&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Pain in Extremity&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133870</classIRI>
<classLabel>PQ/CMC Validation Parameter Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Validation Parameter Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Validation Parameter Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133847</classIRI>
<classLabel>PQ/CMC Chemical Structure Data File Origin Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Chemical Structure Data File Origin Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Chemical Structure Data File Origin Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133857</classIRI>
<classLabel>PQ/CMC Interpretation Code (text) Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Interpretation Code (text) Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Interpretation Code (text) Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133850</classIRI>
<classLabel>PQ/CMC Compendial Method Verification Indicator Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Compendial Method Verification Indicator Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Compendial Method Verification Indicator Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133855</classIRI>
<classLabel>PQ/CMC Drug Substance Product Indicator Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Drug Substance Product Indicator Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Drug Substance Product Indicator Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6523</classIRI>
<classLabel>Malignant Testicular Sertoli Cell Tumor</classLabel>
<deletedAxiom>&apos;Malignant Testicular Sertoli Cell Tumor&apos; EquivalentTo &apos;Testicular Sertoli Cell Tumor&apos; and &apos;Malignant Sertoli Cell Tumor&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Cellular Pleomorphism&apos;)</deletedAxiom>
<newAxiom>&apos;Malignant Testicular Sertoli Cell Tumor&apos; EquivalentTo &apos;Testicular Sertoli Cell Tumor&apos; and &apos;Malignant Sertoli Cell Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6461</classIRI>
<classLabel>Thymic Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Thymic Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Thymic Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Thymic Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Thymic Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133712</classIRI>
<classLabel>Metastatic Paraganglioma</classLabel>
<deletedAxiom>&apos;Metastatic Paraganglioma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Paraganglioma&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6974</classIRI>
<classLabel>Neoplasm of Uncertain Histogenesis</classLabel>
<deletedAxiom>&apos;Neoplasm of Uncertain Histogenesis&apos; EquivalentTo &apos;Neoplasm by Morphology&apos; and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Tissue&apos;) and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Precise Histogenesis Unknown&apos;)</deletedAxiom>
<newAxiom>&apos;Neoplasm of Uncertain Histogenesis&apos; EquivalentTo &apos;Neoplasm by Special Category&apos; and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Tissue&apos;) and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Precise Histogenesis Unknown&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6971</classIRI>
<classLabel>Meningothelial Cell Neoplasm</classLabel>
<deletedAxiom>&apos;Meningothelial Cell Neoplasm&apos; EquivalentTo &apos;Neoplasm by Morphology&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Meningothelial Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Meningothelial Cell&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;)</deletedAxiom>
<newAxiom>&apos;Meningothelial Cell Neoplasm&apos; EquivalentTo &apos;Mesenchymal Cell Neoplasm&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Meningothelial Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Meningothelial Cell&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133239</classIRI>
<classLabel>SPL Blood and Tissue Form Terminology</classLabel>
<deletedAxiom>&apos;SPL Blood and Tissue Form Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;SPL Blood and Tissue Form Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172807</classIRI>
<classLabel>X-Linked Protoporphyria</classLabel>
<newAxiom>&apos;X-Linked Protoporphyria&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191908</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39822</classIRI>
<classLabel>Infiltrating Bladder Urothelial Carcinoma, Lymphoma-Like Variant</classLabel>
<deletedAxiom>&apos;Infiltrating Bladder Urothelial Carcinoma, Lymphoma-Like Variant&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Infiltrating Bladder Urothelial Carcinoma, Lymphoma-Like Variant&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98175</classIRI>
<classLabel>Dynein Light Chain Roadblock-Type 1</classLabel>
<deletedAxiom>&apos;Dynein Light Chain Roadblock-Type 1&apos; EquivalentTo &apos;Transport Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Microtubule Associated Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Microtubule&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Transport&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DYNLRB1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Dynein Light Chain Roadblock-Type 1&apos; EquivalentTo &apos;Transport Protein&apos; and &apos;Microtubule Associated Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;TGF-Beta Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Transport&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;DYNLRB1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98173</classIRI>
<classLabel>DYNLRB1 Gene</classLabel>
<newAxiom>&apos;DYNLRB1 Gene&apos; SubClassOf &apos;Cytoskeletal Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64834</classIRI>
<classLabel>GTX Regimen</classLabel>
<newAxiom>&apos;GTX Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Intestinal Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39934</classIRI>
<classLabel>Testicular Trophoblastic Tumor</classLabel>
<deletedAxiom>&apos;Testicular Trophoblastic Tumor&apos; EquivalentTo &apos;Trophoblastic Tumor&apos; and &apos;Testicular Pure Germ Cell Tumor&apos; and &apos;Testicular Non-Seminomatous Germ Cell Tumor&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Syncytiotrophoblastic Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Cytotrophoblastic Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Intermediate Type Trophoblastic Cell&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Neoplastic Sex Cord-Stromal Cell&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Malignant Large Germ Cell with Abundant Cytoplasm&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Seminomatous Component Present&apos;)</deletedAxiom>
<newAxiom>&apos;Testicular Trophoblastic Tumor&apos; EquivalentTo &apos;Trophoblastic Tumor&apos; and &apos;Testicular Non-Seminomatous Germ Cell Tumor&apos; and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Neoplastic Sex Cord-Stromal Cell&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Malignant Large Germ Cell with Abundant Cytoplasm&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Seminomatous Component Present&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39953</classIRI>
<classLabel>Testicular Brenner Tumor</classLabel>
<deletedAxiom>&apos;Testicular Brenner Tumor&apos; EquivalentTo &apos;Testicular Neoplasm&apos; and &apos;Brenner Tumor&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Testis&apos;) and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Male Reproductive System&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Testicular Tissue&apos;)</deletedAxiom>
<newAxiom>&apos;Testicular Brenner Tumor&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192122 and &apos;Brenner Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39956</classIRI>
<classLabel>Rete Testis Adenoma</classLabel>
<deletedAxiom>&apos;Rete Testis Adenoma&apos; EquivalentTo &apos;Rete Testis Neoplasm&apos; and &apos;Benign Male Reproductive System Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Rete Testis&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Epithelium&apos;) and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Epithelial Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Epithelial Cell&apos;)</deletedAxiom>
<newAxiom>&apos;Rete Testis Adenoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192122 and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140 and &apos;Rete Testis Neoplasm&apos; and &apos;Cystic Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Rete Testis&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39957</classIRI>
<classLabel>Epididymal Adenocarcinoma</classLabel>
<deletedAxiom>&apos;Epididymal Adenocarcinoma&apos; EquivalentTo &apos;Male Reproductive System Carcinoma&apos; and &apos;Adenocarcinoma&apos; and &apos;Malignant Epididymal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Epididymis&apos;)</deletedAxiom>
<newAxiom>&apos;Epididymal Adenocarcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192120 and &apos;Adenocarcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39942</classIRI>
<classLabel>Malignant Testicular Leydig Cell Tumor</classLabel>
<deletedAxiom>&apos;Malignant Testicular Leydig Cell Tumor&apos; EquivalentTo &apos;Malignant Leydig Cell Tumor&apos; and &apos;Testicular Leydig Cell Tumor&apos;</deletedAxiom>
<newAxiom>&apos;Malignant Testicular Leydig Cell Tumor&apos; EquivalentTo &apos;Malignant Leydig Cell Tumor&apos; and &apos;Testicular Leydig Cell Tumor&apos; and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;CDK4 Gene Amplification&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;MDM2 Gene Amplification&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39944</classIRI>
<classLabel>Testicular Large Cell Calcifying Sertoli Cell Tumor</classLabel>
<deletedAxiom>&apos;Testicular Large Cell Calcifying Sertoli Cell Tumor&apos; EquivalentTo &apos;Testicular Sertoli Cell Tumor&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Large Polygonal Sertoli Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Calcification&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Gynecomastia&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Carney Complex&apos;)</deletedAxiom>
<newAxiom>&apos;Testicular Large Cell Calcifying Sertoli Cell Tumor&apos; EquivalentTo &apos;Testicular Sertoli Cell Tumor&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Large Polygonal Sertoli Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Calcification&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Gynecomastia&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Carney Complex&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;PRKAR1A Gene Mutation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172612</classIRI>
<classLabel>Recombinant Human Interleukin-22 IgG4-Fc Fusion Protein UTTR1147A</classLabel>
<deletedAxiom>&apos;Recombinant Human Interleukin-22 IgG4-Fc Fusion Protein UTTR1147A&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Recombinant Human Interleukin-22 IgG4-Fc Fusion Protein UTTR1147A&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39902</classIRI>
<classLabel>Prostate Basal Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Prostate Basal Cell Carcinoma&apos; EquivalentTo &apos;Basal Cell Carcinoma&apos; and &apos;Invasive Prostate Carcinoma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Non-Cutaneous Basaloid Cell&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Urinary Retention&apos;)</deletedAxiom>
<newAxiom>&apos;Prostate Basal Cell Carcinoma&apos; EquivalentTo &apos;Basal Cell Carcinoma&apos; and &apos;Invasive Prostate Carcinoma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Non-Cutaneous Basaloid Cell&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39906</classIRI>
<classLabel>Seminal Vesicle Adenocarcinoma</classLabel>
<deletedAxiom>&apos;Seminal Vesicle Adenocarcinoma&apos; EquivalentTo &apos;Malignant Seminal Vesicle Neoplasm&apos; and &apos;Male Reproductive System Carcinoma&apos; and &apos;Adenocarcinoma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Seminal Vesicle&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Papillary Growth Pattern&apos;)</deletedAxiom>
<newAxiom>&apos;Seminal Vesicle Adenocarcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192130 and &apos;Adenocarcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39907</classIRI>
<classLabel>Seminal Vesicle Cystadenoma</classLabel>
<deletedAxiom>&apos;Seminal Vesicle Cystadenoma&apos; EquivalentTo &apos;Seminal Vesicle Mixed Epithelial and Stromal Tumor&apos; and &apos;Benign Seminal Vesicle Neoplasm&apos; and &apos;Cystadenoma&apos;</deletedAxiom>
<newAxiom>&apos;Seminal Vesicle Cystadenoma&apos; EquivalentTo &apos;Benign Seminal Vesicle Neoplasm&apos; and &apos;Cystadenoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39908</classIRI>
<classLabel>Seminal Vesicle Neoplasm</classLabel>
<deletedAxiom>&apos;Seminal Vesicle Neoplasm&apos; EquivalentTo &apos;Paratesticular Neoplasm&apos; and (&apos;Disease_Has_Associated_Anatomic_Site&apos; some &apos;Seminal Vesicle&apos;)</deletedAxiom>
<newAxiom>&apos;Seminal Vesicle Neoplasm&apos; EquivalentTo &apos;Male Reproductive System Neoplasm&apos; and (&apos;Disease_Has_Associated_Anatomic_Site&apos; some &apos;Seminal Vesicle&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172639</classIRI>
<classLabel>BAP1 Tumor Predisposition Syndrome</classLabel>
<deletedAxiom>&apos;BAP1 Tumor Predisposition Syndrome&apos; EquivalentTo &apos;Hereditary Neoplastic Syndrome&apos; and (&apos;Disease_Has_Molecular_Abnormality&apos; some &apos;BAP1 Gene Mutation&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;BAP1-Mutant Clear Cell Renal Cell Carcinoma&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;BAP1-Inactivated Skin Melanocytic Neoplasm&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Skin Basal Cell Carcinoma&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Mesothelioma&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Cutaneous Melanoma&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Uveal Melanoma&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;BAP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;BAP1 Tumor Predisposition Syndrome&apos; EquivalentTo &apos;Hereditary Neoplastic Syndrome&apos; and (&apos;Disease_Has_Molecular_Abnormality&apos; some &apos;BAP1 Gene Mutation&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;BAP1-Mutant Clear Cell Renal Cell Carcinoma&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;BAP1-Inactivated Skin Melanocytic Neoplasm&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Skin Basal Cell Carcinoma&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Cutaneous Melanoma&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Malignant Mesothelioma&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Uveal Melanoma&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;BAP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C50448</classIRI>
<classLabel>Abnormality of Ventricle</classLabel>
<deletedAxiom>&apos;Abnormality of Ventricle&apos; SubClassOf &apos;Congenital or Acquired Anatomic Abnormality&apos;</deletedAxiom>
<newAxiom>&apos;Abnormality of Ventricle&apos; SubClassOf &apos;Cardiovascular System Finding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C50536</classIRI>
<classLabel>Disfigurement</classLabel>
<deletedAxiom>&apos;Disfigurement&apos; SubClassOf &apos;Congenital or Acquired Anatomic Abnormality&apos;</deletedAxiom>
<newAxiom>&apos;Disfigurement&apos; SubClassOf &apos;Finding by Cause&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C147123</classIRI>
<classLabel>MET Codon 963 Splice Mutation</classLabel>
<newAxiom>&apos;MET Codon 963 Splice Mutation&apos; SubClassOf &apos;Exon Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C147124</classIRI>
<classLabel>MET Codon 1010 Splice Mutation</classLabel>
<newAxiom>&apos;MET Codon 1010 Splice Mutation&apos; SubClassOf &apos;Exon Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C147121</classIRI>
<classLabel>IL-2 Mutein/Fc Fusion Protein AMG 592</classLabel>
<deletedAxiom>&apos;IL-2 Mutein/Fc Fusion Protein AMG 592&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;IL-2 Mutein/Fc Fusion Protein AMG 592&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186789</classIRI>
<classLabel>Neurodevelopmental Disorder with Brain Abnormalities, Poor Growth, and Dysmorphic Facies</classLabel>
<newAxiom>&apos;Neurodevelopmental Disorder with Brain Abnormalities, Poor Growth, and Dysmorphic Facies&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191897</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98910</classIRI>
<classLabel>Cytochrome-C Oxidase Deficiency</classLabel>
<newAxiom>&apos;Cytochrome-C Oxidase Deficiency&apos; SubClassOf &apos;Mitochondrial Enzyme Deficiency&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C148259</classIRI>
<classLabel>Joubert Syndrome 3</classLabel>
<newAxiom>&apos;Joubert Syndrome 3&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191904</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173394</classIRI>
<classLabel>Laryngeal Poorly Differentiated Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Laryngeal Poorly Differentiated Neuroendocrine Carcinoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Laryngeal Poorly Differentiated Neuroendocrine Carcinoma&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173389</classIRI>
<classLabel>Head and Neck Poorly Differentiated Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Head and Neck Poorly Differentiated Neuroendocrine Carcinoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Head and Neck Poorly Differentiated Neuroendocrine Carcinoma&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84549</classIRI>
<classLabel>Alstrom Syndrome</classLabel>
<newAxiom>&apos;Alstrom Syndrome&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191921</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C100045</classIRI>
<classLabel>Manufacturer Recall</classLabel>
<deletedAxiom>&apos;Manufacturer Recall&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Manufacturer Recall&apos; SubClassOf &apos;Administrative Activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173163</classIRI>
<classLabel>Primary Sinonasal Meningioma</classLabel>
<deletedAxiom>&apos;Primary Sinonasal Meningioma&apos; EquivalentTo &apos;Ectopic Meningioma&apos; and &apos;Sinonasal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Sinonasal Tract&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Primary Lesion&apos;)</deletedAxiom>
<newAxiom>&apos;Primary Sinonasal Meningioma&apos; EquivalentTo &apos;Sinonasal Soft Tissue Neoplasm&apos; and &apos;Ectopic Meningioma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Primary Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84679</classIRI>
<classLabel>Dystrophia Myotonica 1</classLabel>
<newAxiom>&apos;Dystrophia Myotonica 1&apos; SubClassOf &apos;Repeat Expansion Disease&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C153623</classIRI>
<classLabel>Recurrent Thyroid Gland Medullary Carcinoma</classLabel>
<deletedAxiom>&apos;Recurrent Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Recurrent Neuroendocrine Carcinoma&apos; and &apos;Thyroid Gland Medullary Carcinoma&apos; and &apos;Recurrent Thyroid Gland Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Thyroid Gland Medullary Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191978 and &apos;Thyroid Gland Medullary Carcinoma&apos; and &apos;Recurrent Thyroid Gland Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187162</classIRI>
<classLabel>Unresectable Lung Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Unresectable Lung Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Unresectable Lung Non-Squamous Non-Small Cell Carcinoma&apos; and &apos;Unresectable Lung Neuroendocrine Neoplasm&apos; and &apos;Unresectable Large Cell Neuroendocrine Carcinoma&apos; and &apos;Lung Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Unresectable Lung Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Unresectable Lung Non-Squamous Non-Small Cell Carcinoma&apos; and &apos;Unresectable Large Cell Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192018 and &apos;Lung Large Cell Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128498</classIRI>
<classLabel>Review Prescribing Information</classLabel>
<deletedAxiom>&apos;Review Prescribing Information&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Review Prescribing Information&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192109</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128492</classIRI>
<classLabel>SPL REMS Protocol Terminology</classLabel>
<deletedAxiom>&apos;SPL REMS Protocol Terminology&apos; SubClassOf &apos;SPL Risk Evaluation and Mitigation Strategies Terminology&apos;</deletedAxiom>
<newAxiom>&apos;SPL REMS Protocol Terminology&apos; SubClassOf &apos;FDA Structured Product Labeling Terminology&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128493</classIRI>
<classLabel>SPL REMS Stakeholder Terminology</classLabel>
<deletedAxiom>&apos;SPL REMS Stakeholder Terminology&apos; SubClassOf &apos;SPL Risk Evaluation and Mitigation Strategies Terminology&apos;</deletedAxiom>
<newAxiom>&apos;SPL REMS Stakeholder Terminology&apos; SubClassOf &apos;FDA Structured Product Labeling Terminology&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128490</classIRI>
<classLabel>SPL Risk Evaluation and Mitigation Strategies Terminology</classLabel>
<deletedAxiom>&apos;SPL Risk Evaluation and Mitigation Strategies Terminology&apos; SubClassOf &apos;FDA Structured Product Labeling Terminology&apos;</deletedAxiom>
<newAxiom>&apos;SPL Risk Evaluation and Mitigation Strategies Terminology&apos; SubClassOf &apos;Unused Subset Concept&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128491</classIRI>
<classLabel>SPL REMS Requirement Terminology</classLabel>
<deletedAxiom>&apos;SPL REMS Requirement Terminology&apos; SubClassOf &apos;SPL Risk Evaluation and Mitigation Strategies Terminology&apos;</deletedAxiom>
<newAxiom>&apos;SPL REMS Requirement Terminology&apos; SubClassOf &apos;FDA Structured Product Labeling Terminology&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7047</classIRI>
<classLabel>Functioning Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;Functioning Pituitary Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Functioning Pituitary Gland Neoplasm&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C153427</classIRI>
<classLabel>EGFR Inhibitor DBPR112</classLabel>
<deletedAxiom>&apos;EGFR Inhibitor DBPR112&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;EGFR Inhibitor DBPR112&apos; SubClassOf &apos;HER2 Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7012</classIRI>
<classLabel>Central Nervous System Choriocarcinoma</classLabel>
<deletedAxiom>&apos;Central Nervous System Choriocarcinoma&apos; EquivalentTo &apos;Central Nervous System Nongerminomatous Germ Cell Tumor&apos; and &apos;Choriocarcinoma&apos; and &apos;Malignant Central Nervous System Germ Cell Tumor&apos; and &apos;Malignant Extragonadal Nongerminomatous Germ Cell Tumor&apos;</deletedAxiom>
<newAxiom>&apos;Central Nervous System Choriocarcinoma&apos; EquivalentTo &apos;Central Nervous System Nongerminomatous Germ Cell Tumor&apos; and &apos;Choriocarcinoma&apos; and &apos;Malignant Central Nervous System Germ Cell Tumor&apos; and &apos;Central Nervous System Carcinoma&apos; and &apos;Malignant Extragonadal Nongerminomatous Germ Cell Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45935</classIRI>
<classLabel>Pituitary Gland Oncocytic Adenoma</classLabel>
<deletedAxiom>&apos;Pituitary Gland Oncocytic Adenoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Pituitary Gland Oncocytic Adenoma&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128511</classIRI>
<classLabel>Do Not Dispense Refills</classLabel>
<deletedAxiom>&apos;Do Not Dispense Refills&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Do Not Dispense Refills&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192109</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128512</classIRI>
<classLabel>Prescribe Limited Days Supply</classLabel>
<deletedAxiom>&apos;Prescribe Limited Days Supply&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Prescribe Limited Days Supply&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192109</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128510</classIRI>
<classLabel>Do Not Prescribe Refills</classLabel>
<deletedAxiom>&apos;Do Not Prescribe Refills&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Do Not Prescribe Refills&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192109</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128517</classIRI>
<classLabel>Return Unused Product</classLabel>
<deletedAxiom>&apos;Return Unused Product&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Return Unused Product&apos; SubClassOf &apos;Administrative Activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128518</classIRI>
<classLabel>Do Not Distribute, Transfer, Loan, or Sell Product</classLabel>
<deletedAxiom>&apos;Do Not Distribute, Transfer, Loan, or Sell Product&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Do Not Distribute, Transfer, Loan, or Sell Product&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192109</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128513</classIRI>
<classLabel>Dispense Limited Days Supply</classLabel>
<deletedAxiom>&apos;Dispense Limited Days Supply&apos; SubClassOf &apos;Medical Product Usage and Evaluation&apos;</deletedAxiom>
<newAxiom>&apos;Dispense Limited Days Supply&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192109</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7733</classIRI>
<classLabel>Testicular Choriocarcinoma</classLabel>
<deletedAxiom>&apos;Testicular Choriocarcinoma&apos; EquivalentTo &apos;Choriocarcinoma&apos; and &apos;Testicular Trophoblastic Tumor&apos; and &apos;Malignant Testicular Non-Seminomatous Germ Cell Tumor&apos;</deletedAxiom>
<newAxiom>&apos;Testicular Choriocarcinoma&apos; EquivalentTo &apos;Choriocarcinoma&apos; and &apos;Testicular Pure Germ Cell Tumor&apos; and &apos;Testicular Trophoblastic Tumor&apos; and &apos;Malignant Testicular Non-Seminomatous Germ Cell Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128245</classIRI>
<classLabel>Vulvar Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Vulvar Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Vulvar Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Vulvar Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Vulvar Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128246</classIRI>
<classLabel>XPO1 Inhibitor SL-801</classLabel>
<deletedAxiom>&apos;XPO1 Inhibitor SL-801&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;XPO1 Inhibitor SL-801&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128243</classIRI>
<classLabel>Vulvar Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Vulvar Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and &apos;Vulvar Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Vulvar Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Vulvar Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7635</classIRI>
<classLabel>Well Differentiated Papillary Mesothelial Tumor</classLabel>
<deletedAxiom>&apos;Well Differentiated Papillary Mesothelial Tumor&apos; EquivalentTo &apos;Mesothelioma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Papillary Growth Pattern&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Well Differentiated Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Localized Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Absence of Invasion or Limited Invasion Present&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Indolent Clinical Course&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Mitotic Activity&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Atypia&apos;)</deletedAxiom>
<newAxiom>&apos;Well Differentiated Papillary Mesothelial Tumor&apos; EquivalentTo &apos;Mesothelial Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Papillary Growth Pattern&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Well Differentiated Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Localized Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Absence of Invasion or Limited Invasion Present&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Indolent Clinical Course&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Mitotic Activity&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Atypia&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7632</classIRI>
<classLabel>Pericardial Mesothelioma</classLabel>
<deletedAxiom>&apos;Pericardial Mesothelioma&apos; EquivalentTo &apos;Mesothelioma&apos; and &apos;Pericardial Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Pericardial Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Pericardium&apos;)</deletedAxiom>
<newAxiom>&apos;Pericardial Mesothelioma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7633</classIRI>
<classLabel>Peritoneal Mesothelioma</classLabel>
<deletedAxiom>&apos;Peritoneal Mesothelioma&apos; EquivalentTo &apos;Mesothelioma&apos; and &apos;Peritoneal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneum&apos;)</deletedAxiom>
<newAxiom>&apos;Peritoneal Mesothelioma&apos; EquivalentTo &apos;Peritoneal Neoplasm&apos; and &apos;Mesothelial Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Peritoneal Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Peritoneum&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7631</classIRI>
<classLabel>Pericardial Malignant Mesothelioma</classLabel>
<deletedAxiom>&apos;Pericardial Malignant Mesothelioma&apos; EquivalentTo &apos;Malignant Mesothelioma&apos; and &apos;Malignant Pericardial Neoplasm&apos; and &apos;Pericardial Mesothelioma&apos; and (&apos;Disease_May_Have_Finding&apos; some &apos;Pericardial Effusion&apos;)</deletedAxiom>
<newAxiom>&apos;Pericardial Malignant Mesothelioma&apos; EquivalentTo &apos;Malignant Mesothelioma&apos; and &apos;Malignant Pericardial Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Pericardial Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Pericardium&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Pericardial Effusion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7586</classIRI>
<classLabel>Malignant Basal Cell Neoplasm</classLabel>
<deletedAxiom>&apos;Malignant Basal Cell Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Malignant Basal Cell Neoplasm&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128075</classIRI>
<classLabel>Vaginal Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Vaginal Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Vaginal Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Vaginal Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Vaginal Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128073</classIRI>
<classLabel>Vaginal Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Vaginal Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and &apos;Vaginal Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Vaginal Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Vaginal Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128045</classIRI>
<classLabel>Cervical Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Cervical Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Cervical Neuroendocrine Neoplasm&apos; and &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and &apos;Cervical Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Cervical Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Cervical Neuroendocrine Neoplasm&apos; and &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Cervical Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7325</classIRI>
<classLabel>Intratubular Non-Seminoma</classLabel>
<deletedAxiom>&apos;Intratubular Non-Seminoma&apos; EquivalentTo &apos;Testicular Intratubular Germ Cell Neoplasia&apos; and &apos;Testicular Embryonal Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Intratubular Non-Seminoma&apos; EquivalentTo &apos;Testicular Intratubular Germ Cell Neoplasia&apos; and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Malignant Large Germ Cell with Abundant Cytoplasm&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142141</classIRI>
<classLabel>Roof of Nasopharynx</classLabel>
<deletedAxiom>&apos;Roof of Nasopharynx&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Roof of Nasopharynx&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C117220</classIRI>
<classLabel>DU-145</classLabel>
<deletedAxiom>&apos;DU-145&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;DU-145&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156508</classIRI>
<classLabel>Monoclonal Protein Spike to Total Protein Ratio Measurement</classLabel>
<deletedAxiom>&apos;Monoclonal Protein Spike to Total Protein Ratio Measurement&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Monoclonal Protein Spike to Total Protein Ratio Measurement&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156689</classIRI>
<classLabel>Advanced Small Intestinal Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Advanced Small Intestinal Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Advanced Small Intestinal Neuroendocrine Carcinoma&apos; and &apos;Advanced Large Cell Neuroendocrine Carcinoma&apos; and &apos;Small Intestinal Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Advanced Small Intestinal Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Advanced Small Intestinal Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191990 and &apos;Small Intestinal Large Cell Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156688</classIRI>
<classLabel>Advanced Small Intestinal Small Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Advanced Small Intestinal Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Advanced Small Intestinal Neuroendocrine Carcinoma&apos; and &apos;Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; and &apos;Small Intestinal Small Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Advanced Small Intestinal Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Advanced Small Intestinal Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191993 and &apos;Small Intestinal Small Cell Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156687</classIRI>
<classLabel>Advanced Small Intestinal Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Advanced Small Intestinal Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Advanced Neuroendocrine Carcinoma&apos; and &apos;Metastatic Small Intestinal Neuroendocrine Carcinoma&apos; and &apos;Advanced Digestive System Carcinoma&apos; and &apos;Advanced Digestive System Neuroendocrine Neoplasm&apos; and &apos;Advanced Malignant Small Intestinal Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Advanced Small Intestinal Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Metastatic Small Intestinal Neuroendocrine Carcinoma&apos; and &apos;Advanced Digestive System Carcinoma&apos; and &apos;Advanced Digestive System Neuroendocrine Neoplasm&apos; and &apos;Advanced Malignant Small Intestinal Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191982</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156685</classIRI>
<classLabel>Advanced Gastric Small Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Advanced Gastric Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Advanced Gastric Neuroendocrine Carcinoma&apos; and &apos;Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; and &apos;Gastric Small Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Advanced Gastric Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Advanced Gastric Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191993 and &apos;Gastric Small Cell Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156684</classIRI>
<classLabel>Advanced Gastric Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Advanced Gastric Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Advanced Gastric Neuroendocrine Carcinoma&apos; and &apos;Advanced Large Cell Neuroendocrine Carcinoma&apos; and &apos;Gastric Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Advanced Gastric Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Advanced Gastric Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191990 and &apos;Gastric Large Cell Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156683</classIRI>
<classLabel>Advanced Gastric Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Advanced Gastric Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Advanced Neuroendocrine Carcinoma&apos; and &apos;Metastatic Gastric Neuroendocrine Carcinoma&apos; and &apos;Advanced Digestive System Neuroendocrine Neoplasm&apos; and &apos;Advanced Gastric Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Advanced Gastric Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Metastatic Gastric Neuroendocrine Carcinoma&apos; and &apos;Advanced Digestive System Neuroendocrine Neoplasm&apos; and &apos;Advanced Gastric Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191982</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C122997</classIRI>
<classLabel>Motivation Visual Analogue Scale</classLabel>
<deletedAxiom>&apos;Motivation Visual Analogue Scale&apos; SubClassOf &apos;Research or Clinical Assessment Tool&apos;</deletedAxiom>
<newAxiom>&apos;Motivation Visual Analogue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156457</classIRI>
<classLabel>Extrapulmonary Small Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Small Cell Neuroendocrine Carcinoma&apos; and (&apos;Disease_Excludes_Primary_Anatomic_Site&apos; some &apos;Lung&apos;)</deletedAxiom>
<newAxiom>&apos;Extrapulmonary Small Cell Neuroendocrine Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Small Cell Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99127</classIRI>
<classLabel>Varlilumab</classLabel>
<deletedAxiom>&apos;Varlilumab&apos; SubClassOf &apos;Monoclonal Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Varlilumab&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192186</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99224</classIRI>
<classLabel>Bi-functional Alkylating Agent VAL-083</classLabel>
<deletedAxiom>&apos;Bi-functional Alkylating Agent VAL-083&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Bi-functional Alkylating Agent VAL-083&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C181139</classIRI>
<classLabel>Soluble CD40 Ligand Measurement</classLabel>
<deletedAxiom>&apos;Soluble CD40 Ligand Measurement&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Soluble CD40 Ligand Measurement&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C181138</classIRI>
<classLabel>Soluble CD40 Measurement</classLabel>
<deletedAxiom>&apos;Soluble CD40 Measurement&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Soluble CD40 Measurement&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156154</classIRI>
<classLabel>Recombinant Ornithodoros moubata Saliva-derived Small Protein Complement C5 Inhibitor</classLabel>
<deletedAxiom>&apos;Recombinant Ornithodoros moubata Saliva-derived Small Protein Complement C5 Inhibitor&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Recombinant Ornithodoros moubata Saliva-derived Small Protein Complement C5 Inhibitor&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26848</classIRI>
<classLabel>Peritoneal Disorder</classLabel>
<deletedAxiom>&apos;Peritoneal Disorder&apos; SubClassOf &apos;Disease_Has_Associated_Anatomic_Site&apos; some &apos;Peritoneum&apos;</deletedAxiom>
<newAxiom>&apos;Peritoneal Disorder&apos; SubClassOf &apos;Disease_Has_Associated_Anatomic_Site&apos; some &apos;Peritoneal Cavity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C161639</classIRI>
<classLabel>Seminal Vesicle Schwannoma</classLabel>
<deletedAxiom>&apos;Seminal Vesicle Schwannoma&apos; EquivalentTo &apos;Seminal Vesicle Soft Tissue Neoplasm&apos; and &apos;Benign Seminal Vesicle Neoplasm&apos; and &apos;Paratesticular Schwannoma&apos;</deletedAxiom>
<newAxiom>&apos;Seminal Vesicle Schwannoma&apos; EquivalentTo &apos;Seminal Vesicle Soft Tissue Neoplasm&apos; and &apos;Benign Seminal Vesicle Neoplasm&apos; and &apos;Schwannoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C161634</classIRI>
<classLabel>Seminal Vesicle Squamous Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Seminal Vesicle Squamous Cell Carcinoma&apos; EquivalentTo &apos;Malignant Seminal Vesicle Neoplasm&apos; and &apos;Paratesticular Squamous Cell Carcinoma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Seminal Vesicle&apos;)</deletedAxiom>
<newAxiom>&apos;Seminal Vesicle Squamous Cell Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192130 and &apos;Squamous Cell Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C161638</classIRI>
<classLabel>Seminal Vesicle Leiomyoma</classLabel>
<deletedAxiom>&apos;Seminal Vesicle Leiomyoma&apos; EquivalentTo &apos;Seminal Vesicle Soft Tissue Neoplasm&apos; and &apos;Benign Seminal Vesicle Neoplasm&apos; and &apos;Paratesticular Leiomyoma&apos;</deletedAxiom>
<newAxiom>&apos;Seminal Vesicle Leiomyoma&apos; EquivalentTo &apos;Seminal Vesicle Soft Tissue Neoplasm&apos; and &apos;Benign Seminal Vesicle Neoplasm&apos; and &apos;Leiomyoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C161637</classIRI>
<classLabel>Seminal Vesicle Soft Tissue Neoplasm</classLabel>
<deletedAxiom>&apos;Seminal Vesicle Soft Tissue Neoplasm&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Seminal Vesicle Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Seminal Vesicle&apos;)</deletedAxiom>
<newAxiom>&apos;Seminal Vesicle Soft Tissue Neoplasm&apos; EquivalentTo &apos;Soft Tissue Neoplasm&apos; and &apos;Seminal Vesicle Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Seminal Vesicle&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C161641</classIRI>
<classLabel>Seminal Vesicle Leiomyosarcoma</classLabel>
<deletedAxiom>&apos;Seminal Vesicle Leiomyosarcoma&apos; EquivalentTo &apos;Seminal Vesicle Soft Tissue Neoplasm&apos; and &apos;Malignant Seminal Vesicle Neoplasm&apos; and &apos;Paratesticular Leiomyosarcoma&apos;</deletedAxiom>
<newAxiom>&apos;Seminal Vesicle Leiomyosarcoma&apos; EquivalentTo &apos;Seminal Vesicle Soft Tissue Neoplasm&apos; and &apos;Malignant Seminal Vesicle Neoplasm&apos; and &apos;Leiomyosarcoma&apos; and &apos;Soft Tissue Sarcoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C161640</classIRI>
<classLabel>Seminal Vesicle Mammary-Type Myofibroblastoma</classLabel>
<deletedAxiom>&apos;Seminal Vesicle Mammary-Type Myofibroblastoma&apos; EquivalentTo &apos;Seminal Vesicle Soft Tissue Neoplasm&apos; and &apos;Benign Seminal Vesicle Neoplasm&apos; and &apos;Paratesticular Mammary-Type Myofibroblastoma&apos;</deletedAxiom>
<newAxiom>&apos;Seminal Vesicle Mammary-Type Myofibroblastoma&apos; EquivalentTo &apos;Mammary-Type Myofibroblastoma&apos; and &apos;Seminal Vesicle Soft Tissue Neoplasm&apos; and &apos;Benign Seminal Vesicle Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C85461</classIRI>
<classLabel>Iodine I 123 Iodobenzamide</classLabel>
<deletedAxiom>&apos;Iodine I 123 Iodobenzamide&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Iodine I 123 Iodobenzamide&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C136546</classIRI>
<classLabel>Neck Pain Scale</classLabel>
<newAxiom>&apos;Neck Pain Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162503</classIRI>
<classLabel>Paratesticular Hemangioma</classLabel>
<deletedAxiom>&apos;Paratesticular Hemangioma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Hemangioma&apos; and &apos;Benign Soft Tissue Neoplasm&apos; and &apos;Benign Male Reproductive System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Hemangioma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140 and &apos;Hemangioma&apos; and &apos;Benign Soft Tissue Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162502</classIRI>
<classLabel>Paratesticular Schwannoma</classLabel>
<deletedAxiom>&apos;Paratesticular Schwannoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Peripheral Nerve Schwannoma&apos; and &apos;Benign Male Reproductive System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Schwannoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140 and &apos;Peripheral Nerve Schwannoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162501</classIRI>
<classLabel>Paratesticular Deep (Aggressive) Angiomyxoma</classLabel>
<deletedAxiom>&apos;Paratesticular Deep (Aggressive) Angiomyxoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Benign Male Reproductive System Neoplasm&apos; and &apos;Deep (Aggressive) Angiomyxoma&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Deep (Aggressive) Angiomyxoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140 and &apos;Deep (Aggressive) Angiomyxoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162500</classIRI>
<classLabel>Paratesticular Mammary-Type Myofibroblastoma</classLabel>
<deletedAxiom>&apos;Paratesticular Mammary-Type Myofibroblastoma&apos; EquivalentTo &apos;Mammary-Type Myofibroblastoma&apos; and &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Benign Male Reproductive System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Mammary-Type Myofibroblastoma&apos; EquivalentTo &apos;Mammary-Type Myofibroblastoma&apos; and &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162572</classIRI>
<classLabel>Metastatic Merkel Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Metastatic Merkel Cell Carcinoma&apos; EquivalentTo &apos;Metastatic Neuroendocrine Carcinoma&apos; and &apos;Metastatic Malignant Skin Neoplasm&apos; and &apos;Merkel Cell Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Merkel Cell Carcinoma&apos; EquivalentTo &apos;Metastatic Malignant Skin Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191981 and &apos;Merkel Cell Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C123071</classIRI>
<classLabel>Nephrotic Syndrome - ARHGDIA Associated</classLabel>
<newAxiom>&apos;Nephrotic Syndrome - ARHGDIA Associated&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192002</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C123070</classIRI>
<classLabel>Nephrotic Syndrome - ARHGAP24 Associated</classLabel>
<newAxiom>&apos;Nephrotic Syndrome - ARHGAP24 Associated&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191998</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C123068</classIRI>
<classLabel>Nephrotic Syndrome - ADCK4 Associated</classLabel>
<newAxiom>&apos;Nephrotic Syndrome - ADCK4 Associated&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191900</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176901</classIRI>
<classLabel>Spinocerebellar Ataxia Type 31</classLabel>
<newAxiom>&apos;Spinocerebellar Ataxia Type 31&apos; SubClassOf &apos;Repeat Expansion Disease&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1710</classIRI>
<classLabel>Pentetic Acid Calcium</classLabel>
<deletedAxiom>&apos;Pentetic Acid Calcium&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Pentetic Acid Calcium&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176983</classIRI>
<classLabel>Anti-PD-L1/CD27 Bispecific Antibody CDX-527</classLabel>
<deletedAxiom>&apos;Anti-PD-L1/CD27 Bispecific Antibody CDX-527&apos; SubClassOf &apos;Antineoplastic Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Anti-PD-L1/CD27 Bispecific Antibody CDX-527&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192186</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162490</classIRI>
<classLabel>Paratesticular Paraganglioma</classLabel>
<deletedAxiom>&apos;Paratesticular Paraganglioma&apos; EquivalentTo &apos;Paratesticular Neoplasm&apos; and &apos;Extra-Adrenal Paraganglioma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Paratesticular Region&apos;)</deletedAxiom>
<newAxiom>&apos;Paratesticular Paraganglioma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192122 and &apos;Extra-Adrenal Paraganglioma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162483</classIRI>
<classLabel>Epididymal Cystadenoma</classLabel>
<deletedAxiom>&apos;Epididymal Cystadenoma&apos; EquivalentTo &apos;Cystadenoma&apos; and &apos;Benign Epididymal Neoplasm&apos; and &apos;Benign Epithelial Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Epididymal Cystadenoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192122 and &apos;Cystadenoma&apos; and &apos;Benign Epididymal Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162488</classIRI>
<classLabel>Epididymal Melanotic Neuroectodermal Tumor</classLabel>
<deletedAxiom>&apos;Epididymal Melanotic Neuroectodermal Tumor&apos; EquivalentTo &apos;Paratesticular Melanotic Neuroectodermal Tumor&apos; and &apos;Epididymal Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Epididymis&apos;)</deletedAxiom>
<newAxiom>&apos;Epididymal Melanotic Neuroectodermal Tumor&apos; EquivalentTo &apos;Benign Epididymal Neoplasm&apos; and &apos;Melanotic Neuroectodermal Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162487</classIRI>
<classLabel>Paratesticular Melanotic Neuroectodermal Tumor</classLabel>
<deletedAxiom>&apos;Paratesticular Melanotic Neuroectodermal Tumor&apos; EquivalentTo &apos;Paratesticular Neoplasm&apos; and &apos;Melanotic Neuroectodermal Tumor&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Paratesticular Region&apos;)</deletedAxiom>
<newAxiom>&apos;Paratesticular Melanotic Neuroectodermal Tumor&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162486</classIRI>
<classLabel>Paratesticular Squamous Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Paratesticular Squamous Cell Carcinoma&apos; EquivalentTo &apos;Paratesticular Neoplasm&apos; and &apos;Squamous Cell Carcinoma&apos; and &apos;Malignant Male Reproductive System Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Paratesticular Region&apos;)</deletedAxiom>
<newAxiom>&apos;Paratesticular Squamous Cell Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192129 and &apos;Squamous Cell Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162489</classIRI>
<classLabel>Paratesticular Wilms Tumor</classLabel>
<deletedAxiom>&apos;Paratesticular Wilms Tumor&apos; EquivalentTo &apos;Paratesticular Neoplasm&apos; and &apos;Wilms Tumor&apos; and &apos;Malignant Male Reproductive System Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Paratesticular Region&apos;)</deletedAxiom>
<newAxiom>&apos;Paratesticular Wilms Tumor&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192139 and &apos;Wilms Tumor&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Paratesticular Region&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162495</classIRI>
<classLabel>Paratesticular Leiomyosarcoma</classLabel>
<deletedAxiom>&apos;Paratesticular Leiomyosarcoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Leiomyosarcoma&apos; and &apos;Malignant Male Reproductive System Neoplasm&apos; and &apos;Soft Tissue Sarcoma&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Leiomyosarcoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192139 and &apos;Leiomyosarcoma&apos; and &apos;Soft Tissue Sarcoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162494</classIRI>
<classLabel>Paratesticular Leiomyoma</classLabel>
<deletedAxiom>&apos;Paratesticular Leiomyoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Leiomyoma&apos; and &apos;Benign Male Reproductive System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Leiomyoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140 and &apos;Leiomyoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162493</classIRI>
<classLabel>Paratesticular Liposarcoma</classLabel>
<deletedAxiom>&apos;Paratesticular Liposarcoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Liposarcoma&apos; and &apos;Malignant Male Reproductive System Neoplasm&apos; and &apos;Soft Tissue Sarcoma&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Liposarcoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192139 and &apos;Liposarcoma&apos; and &apos;Soft Tissue Sarcoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162498</classIRI>
<classLabel>Paratesticular Cellular Angiofibroma</classLabel>
<deletedAxiom>&apos;Paratesticular Cellular Angiofibroma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Cellular Angiofibroma&apos; and &apos;Benign Male Reproductive System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Cellular Angiofibroma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140 and &apos;Cellular Angiofibroma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162497</classIRI>
<classLabel>Paratesticular Rhabdomyosarcoma</classLabel>
<deletedAxiom>&apos;Paratesticular Rhabdomyosarcoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Rhabdomyosarcoma&apos; and &apos;Malignant Male Reproductive System Neoplasm&apos; and &apos;Soft Tissue Sarcoma&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Rhabdomyosarcoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192139 and &apos;Rhabdomyosarcoma&apos; and &apos;Soft Tissue Sarcoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162496</classIRI>
<classLabel>Paratesticular Rhabdomyoma</classLabel>
<deletedAxiom>&apos;Paratesticular Rhabdomyoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and &apos;Benign Male Reproductive System Neoplasm&apos; and &apos;Extracardiac Rhabdomyoma&apos;</deletedAxiom>
<newAxiom>&apos;Paratesticular Rhabdomyoma&apos; EquivalentTo &apos;Paratesticular Soft Tissue Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140 and &apos;Extracardiac Rhabdomyoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162477</classIRI>
<classLabel>Paratesticular Malignant Mesothelioma</classLabel>
<deletedAxiom>&apos;Paratesticular Malignant Mesothelioma&apos; EquivalentTo &apos;Paratesticular Neoplasm&apos; and &apos;Malignant Mesothelioma&apos; and &apos;Malignant Male Reproductive System Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Tunica Vaginalis&apos;)</deletedAxiom>
<newAxiom>&apos;Paratesticular Malignant Mesothelioma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192139 and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192144 and &apos;Malignant Mesothelioma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Tunica Vaginalis&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162476</classIRI>
<classLabel>Paratesticular Adenomatoid Tumor</classLabel>
<deletedAxiom>&apos;Paratesticular Adenomatoid Tumor&apos; EquivalentTo &apos;Paratesticular Neoplasm&apos; and &apos;Adenomatoid Tumor&apos; and &apos;Benign Male Reproductive System Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Paratesticular Region&apos;)</deletedAxiom>
<newAxiom>&apos;Paratesticular Adenomatoid Tumor&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140 and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192144 and &apos;Adenomatoid Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162479</classIRI>
<classLabel>BTK inhibitor TG-1701</classLabel>
<deletedAxiom>&apos;BTK inhibitor TG-1701&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;BTK inhibitor TG-1701&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176788</classIRI>
<classLabel>PQ/CMC Application Submission Type Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Application Submission Type Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Application Submission Type Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176789</classIRI>
<classLabel>PQ/CMC Co-Packaged Indicator Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Co-Packaged Indicator Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Co-Packaged Indicator Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176790</classIRI>
<classLabel>PQ/CMC Process Related Impurity Category Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Process Related Impurity Category Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Process Related Impurity Category Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176814</classIRI>
<classLabel>PQ/CMC Product Related Impurity Category Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Product Related Impurity Category Terminology&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Product Related Impurity Category Terminology&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176895</classIRI>
<classLabel>Mitochondrial Complex IV Deficiency, Nuclear Type 1</classLabel>
<deletedAxiom>&apos;Mitochondrial Complex IV Deficiency, Nuclear Type 1&apos; SubClassOf &apos;Mitochondrial Enzyme Deficiency&apos;</deletedAxiom>
<newAxiom>&apos;Mitochondrial Complex IV Deficiency, Nuclear Type 1&apos; SubClassOf &apos;Cytochrome-C Oxidase Deficiency&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176587</classIRI>
<classLabel>TP53-Associated Li-Fraumeni Syndrome</classLabel>
<deletedAxiom>&apos;TP53-Associated Li-Fraumeni Syndrome&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;TP53-Associated Li-Fraumeni Syndrome&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71684</classIRI>
<classLabel>Central Pathology Review</classLabel>
<deletedAxiom>&apos;Central Pathology Review&apos; SubClassOf &apos;Review&apos;</deletedAxiom>
<newAxiom>&apos;Central Pathology Review&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191951</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142955</classIRI>
<classLabel>Bictegravir Sodium</classLabel>
<deletedAxiom>&apos;Bictegravir Sodium&apos; SubClassOf &apos;Anti-HIV Agent&apos;</deletedAxiom>
<newAxiom>&apos;Bictegravir Sodium&apos; SubClassOf &apos;HIV Integrase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176497</classIRI>
<classLabel>AP3D1 wt Allele</classLabel>
<deletedAxiom>&apos;AP3D1 wt Allele&apos; SubClassOf &apos;AP3D1 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;AP3D1 wt Allele&apos; SubClassOf &apos;Gene_In_Chromosomal_Location&apos; some &apos;19p13.3&apos;</deletedAxiom>
<deletedAxiom>&apos;AP3D1 wt Allele&apos; SubClassOf &apos;Gene_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;</deletedAxiom>
<newAxiom>&apos;AP3D1 wt Allele&apos; EquivalentTo &apos;AP3D1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Lysosome Assembly Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;19p13.3&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176468</classIRI>
<classLabel>AK2 Gene</classLabel>
<deletedAxiom>&apos;AK2 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Phosphorylation Process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142730</classIRI>
<classLabel>Terminology</classLabel>
<deletedAxiom>&apos;Terminology&apos; SubClassOf &apos;Conceptual Entity&apos;</deletedAxiom>
<newAxiom>&apos;Terminology&apos; SubClassOf &apos;Information Resource&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C117844</classIRI>
<classLabel>Monoclonal Protein Spike Measurement</classLabel>
<deletedAxiom>&apos;Monoclonal Protein Spike Measurement&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Monoclonal Protein Spike Measurement&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C117855</classIRI>
<classLabel>Reticulocyte Mean Corpuscular Hemoglobin Measurement</classLabel>
<deletedAxiom>&apos;Reticulocyte Mean Corpuscular Hemoglobin Measurement&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Reticulocyte Mean Corpuscular Hemoglobin Measurement&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176015</classIRI>
<classLabel>Immunodeficiency 14</classLabel>
<deletedAxiom>&apos;Immunodeficiency 14&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Immunodeficiency 14&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91386</classIRI>
<classLabel>Anti-PGF Monoclonal Antibody RO5323441</classLabel>
<deletedAxiom>&apos;Anti-PGF Monoclonal Antibody RO5323441&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-PGF Monoclonal Antibody RO5323441&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C180404</classIRI>
<classLabel>Refractory Thyroid Gland Medullary Carcinoma</classLabel>
<deletedAxiom>&apos;Refractory Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Refractory Thyroid Gland Carcinoma&apos; and &apos;Refractory Neuroendocrine Carcinoma&apos; and &apos;Thyroid Gland Medullary Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Refractory Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Refractory Thyroid Gland Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191979 and &apos;Thyroid Gland Medullary Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C169820</classIRI>
<classLabel>Cabotegravir</classLabel>
<deletedAxiom>&apos;Cabotegravir&apos; SubClassOf &apos;Anti-HIV Agent&apos;</deletedAxiom>
<newAxiom>&apos;Cabotegravir&apos; SubClassOf &apos;HIV Integrase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91714</classIRI>
<classLabel>Immunotherapeutic GSK1572932A</classLabel>
<deletedAxiom>&apos;Immunotherapeutic GSK1572932A&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Immunotherapeutic GSK1572932A&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66748</classIRI>
<classLabel>Unclassified Testicular Sex Cord-Stromal Tumor</classLabel>
<deletedAxiom>&apos;Unclassified Testicular Sex Cord-Stromal Tumor&apos; EquivalentTo &apos;Testicular Sex Cord-Stromal Tumor&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Tissue Differentiation Uncertain&apos;)</deletedAxiom>
<newAxiom>&apos;Unclassified Testicular Sex Cord-Stromal Tumor&apos; EquivalentTo &apos;Testicular Sex Cord-Stromal Tumor&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Unclassifiable/Not Further Specified Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C27279</classIRI>
<classLabel>Localized Adrenal Gland Pheochromocytoma</classLabel>
<deletedAxiom>&apos;Localized Adrenal Gland Pheochromocytoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Localized Adrenal Gland Pheochromocytoma&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66988</classIRI>
<classLabel>Anti-IL-13 Humanized Monoclonal Antibody TNX-650</classLabel>
<deletedAxiom>&apos;Anti-IL-13 Humanized Monoclonal Antibody TNX-650&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-IL-13 Humanized Monoclonal Antibody TNX-650&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66941</classIRI>
<classLabel>Fluorine F 18 Sodium Fluoride</classLabel>
<deletedAxiom>&apos;Fluorine F 18 Sodium Fluoride&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Fluorine F 18 Sodium Fluoride&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C121545</classIRI>
<classLabel>Fluorescent Protease-activated Peptide AVB-620</classLabel>
<deletedAxiom>&apos;Fluorescent Protease-activated Peptide AVB-620&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Fluorescent Protease-activated Peptide AVB-620&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C121543</classIRI>
<classLabel>Dolutegravir</classLabel>
<deletedAxiom>&apos;Dolutegravir&apos; SubClassOf &apos;Antiviral Agent&apos;</deletedAxiom>
<newAxiom>&apos;Dolutegravir&apos; SubClassOf &apos;HIV Integrase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C160980</classIRI>
<classLabel>Head and Neck Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Head and Neck Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Head and Neck Neuroendocrine Neoplasm&apos; and &apos;Head and Neck Carcinoma&apos; and &apos;Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Head and Neck Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Head and Neck Neuroendocrine Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Head and Neck Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C160982</classIRI>
<classLabel>Head and Neck Large Cell Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Head and Neck Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Head and Neck Neuroendocrine Carcinoma&apos; and &apos;Large Cell Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Head and Neck Large Cell Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Head and Neck Neuroendocrine Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C160890</classIRI>
<classLabel>Anti-AXL/PBD Antibody-drug Conjugate ADCT-601</classLabel>
<deletedAxiom>&apos;Anti-AXL/PBD Antibody-drug Conjugate ADCT-601&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Anti-AXL/PBD Antibody-drug Conjugate ADCT-601&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C160525</classIRI>
<classLabel>Bevacizumab/Liposomal Doxorubicin Regimen</classLabel>
<newAxiom>&apos;Bevacizumab/Liposomal Doxorubicin Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Fallopian Tube Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Bevacizumab/Liposomal Doxorubicin Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Peritoneal Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C160508</classIRI>
<classLabel>Cisplatin/Paclitaxel/Intraperitoneal Paclitaxel Regimen</classLabel>
<newAxiom>&apos;Cisplatin/Paclitaxel/Intraperitoneal Paclitaxel Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Peritoneal Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Cisplatin/Paclitaxel/Intraperitoneal Paclitaxel Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Fallopian Tube Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C160295</classIRI>
<classLabel>Unresectable Lung Small Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Unresectable Lung Small Cell Carcinoma&apos; EquivalentTo &apos;Unresectable Lung Carcinoma&apos; and &apos;Unresectable Lung Neuroendocrine Neoplasm&apos; and &apos;Unresectable Neuroendocrine Carcinoma&apos; and &apos;Lung Small Cell Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Unresectable Lung Small Cell Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192014 and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192018 and &apos;Lung Small Cell Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102983</classIRI>
<classLabel>PBN Derivative OKN-007</classLabel>
<deletedAxiom>&apos;PBN Derivative OKN-007&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;PBN Derivative OKN-007&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C136241</classIRI>
<classLabel>Bevacizumab/Cisplatin/Paclitaxel Regimen</classLabel>
<newAxiom>&apos;Bevacizumab/Cisplatin/Paclitaxel Regimen&apos; SubClassOf &apos;Regimen Used to Treat Vulvar Cancer&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C136243</classIRI>
<classLabel>Capecitabine/Bevacizumab Regimen</classLabel>
<newAxiom>&apos;Capecitabine/Bevacizumab Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Intestinal Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102749</classIRI>
<classLabel>Heparan Sulfate Glycosaminoglycan Mimetic M402</classLabel>
<deletedAxiom>&apos;Heparan Sulfate Glycosaminoglycan Mimetic M402&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Heparan Sulfate Glycosaminoglycan Mimetic M402&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33095</classIRI>
<classLabel>Meningothelial Cell</classLabel>
<deletedAxiom>&apos;Meningothelial Cell&apos; SubClassOf &apos;Cell&apos;</deletedAxiom>
<newAxiom>&apos;Meningothelial Cell&apos; SubClassOf &apos;Connective and Soft Tissue Cell&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102538</classIRI>
<classLabel>Speckle-Type POZ Protein</classLabel>
<deletedAxiom>&apos;Speckle-Type POZ Protein&apos; EquivalentTo &apos;Regulatory Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;BTB/POZ Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Transcription Regulatory Protein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Ubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SPOP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Speckle-Type POZ Protein&apos; EquivalentTo &apos;Ubiquitination Regulation Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Events Mediated by Gli Family Proteins&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;BTB/POZ Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Ubiquitin Protein Ligase&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulation of Proteolysis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Polyubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;SPOP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102537</classIRI>
<classLabel>SPOP wt Allele</classLabel>
<newAxiom>&apos;SPOP wt Allele&apos; SubClassOf &apos;Gene_Is_Element_In_Pathway&apos; some &apos;Hedgehog Signaling Pathway&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102534</classIRI>
<classLabel>SPOP Gene</classLabel>
<deletedAxiom>&apos;SPOP Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Ubiquitination&apos;</deletedAxiom>
<deletedAxiom>&apos;SPOP Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;RNA Processing&apos;</deletedAxiom>
<newAxiom>&apos;SPOP Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Polyubiquitination&apos;</newAxiom>
<newAxiom>&apos;SPOP Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Regulation of Proteolysis&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C175581</classIRI>
<classLabel>Breast Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Breast Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and &apos;Breast Neuroendocrine Neoplasm&apos; and &apos;Invasive Breast Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Breast Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Breast Neuroendocrine Neoplasm&apos; and &apos;Invasive Breast Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72837</classIRI>
<classLabel>Raltegravir</classLabel>
<deletedAxiom>&apos;Raltegravir&apos; SubClassOf &apos;Antiviral Agent&apos;</deletedAxiom>
<newAxiom>&apos;Raltegravir&apos; SubClassOf &apos;HIV Integrase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9351</classIRI>
<classLabel>Pleural Mesothelioma</classLabel>
<deletedAxiom>&apos;Pleural Mesothelioma&apos; EquivalentTo &apos;Mesothelioma&apos; and &apos;Pleural Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Pleural Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Pleura&apos;)</deletedAxiom>
<newAxiom>&apos;Pleural Mesothelioma&apos; EquivalentTo &apos;Pleural Neoplasm&apos; and &apos;Mesothelial Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Pleural Cavity&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Pleura&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189890</classIRI>
<classLabel>Ocifisertib Fumarate</classLabel>
<deletedAxiom>&apos;Ocifisertib Fumarate&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Ocifisertib Fumarate&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116939</classIRI>
<classLabel>FGFR Inhibition</classLabel>
<newAxiom>&apos;FGFR Inhibition&apos; SubClassOf &apos;Targeted Molecular Therapy&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116938</classIRI>
<classLabel>CDK4/6 Inhibition</classLabel>
<newAxiom>&apos;CDK4/6 Inhibition&apos; SubClassOf &apos;Targeted Molecular Therapy&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116875</classIRI>
<classLabel>Thrombopoietin Receptor Agonist LGD-4665</classLabel>
<deletedAxiom>&apos;Thrombopoietin Receptor Agonist LGD-4665&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Thrombopoietin Receptor Agonist LGD-4665&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9231</classIRI>
<classLabel>Merkel Cell Carcinoma</classLabel>
<deletedAxiom>&apos;Merkel Cell Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and &apos;Malignant Dermal Neoplasm&apos; and &apos;Skin Carcinoma&apos; and &apos;Infrequent Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Neuroendocrine Small Round Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Neuroendocrine Differentiation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Single Cell Necrosis&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Cytoplasmic Membrane-Bound Granules Present&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Trisomy 6&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;del(1p36)&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Nodular Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Diffuse Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Trabecular Pattern&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Merkel Cell Polyomavirus Infection&apos;)</deletedAxiom>
<newAxiom>&apos;Merkel Cell Carcinoma&apos; EquivalentTo &apos;Neuroendocrine Carcinoma, Excluding Head and Neck&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977 and &apos;Malignant Dermal Neoplasm&apos; and &apos;Skin Carcinoma&apos; and &apos;Infrequent Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Neuroendocrine Small Round Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;High Mitotic Activity&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Neuroendocrine Differentiation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Single Cell Necrosis&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Cytoplasmic Membrane-Bound Granules Present&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Trisomy 6&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;del(1p36)&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Nodular Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Diffuse Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Trabecular Pattern&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Merkel Cell Polyomavirus Infection&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189974</classIRI>
<classLabel>Dolutegravir Sodium/Rilpivirine Hydrochloride</classLabel>
<deletedAxiom>&apos;Dolutegravir Sodium/Rilpivirine Hydrochloride&apos; SubClassOf &apos;Anti-HIV Agent&apos;</deletedAxiom>
<newAxiom>&apos;Dolutegravir Sodium/Rilpivirine Hydrochloride&apos; SubClassOf &apos;HIV Integrase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189956</classIRI>
<classLabel>Exon Skipping Mutation</classLabel>
<deletedAxiom>&apos;Exon Skipping Mutation&apos; SubClassOf &apos;Exon Mutation&apos;</deletedAxiom>
<newAxiom>&apos;Exon Skipping Mutation&apos; SubClassOf &apos;Splice-Site Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189672</classIRI>
<classLabel>DICER1 NP_803187.1:p.W1831*</classLabel>
<deletedAxiom>&apos;DICER1 NP_803187.1:p.W1831*&apos; SubClassOf &apos;DICER1 NP_803187.1:p.W1831X&apos;</deletedAxiom>
<newAxiom>&apos;DICER1 NP_803187.1:p.W1831*&apos; SubClassOf &apos;DICER1 Protein Variant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189671</classIRI>
<classLabel>DICER1 NM_177438.3:c.5492GA</classLabel>
<newAxiom>&apos;DICER1 NM_177438.3:c.5492GA&apos; SubClassOf &apos;Nonsense Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189634</classIRI>
<classLabel>Additional Disease-Related Findings</classLabel>
<deletedAxiom>&apos;Additional Disease-Related Findings&apos; SubClassOf &apos;Other Finding&apos;</deletedAxiom>
<newAxiom>&apos;Additional Disease-Related Findings&apos; SubClassOf &apos;Finding by Cause&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C175061</classIRI>
<classLabel>Eliapixant</classLabel>
<deletedAxiom>&apos;Eliapixant&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Eliapixant&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116644</classIRI>
<classLabel>Radioangiography</classLabel>
<deletedAxiom>&apos;Radioangiography&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Radioangiography&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141607</classIRI>
<classLabel>Anxiety Visual Analogue Scale</classLabel>
<deletedAxiom>&apos;Anxiety Visual Analogue Scale&apos; SubClassOf &apos;Research or Clinical Assessment Tool&apos;</deletedAxiom>
<newAxiom>&apos;Anxiety Visual Analogue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141619</classIRI>
<classLabel>Well Being Visual Analogue Scale</classLabel>
<deletedAxiom>&apos;Well Being Visual Analogue Scale&apos; SubClassOf &apos;Research or Clinical Assessment Tool&apos;</deletedAxiom>
<newAxiom>&apos;Well Being Visual Analogue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141634</classIRI>
<classLabel>Other Problem Visual Analogue Scale</classLabel>
<deletedAxiom>&apos;Other Problem Visual Analogue Scale&apos; SubClassOf &apos;Research or Clinical Assessment Tool&apos;</deletedAxiom>
<newAxiom>&apos;Other Problem Visual Analogue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67006</classIRI>
<classLabel>Malignant Sertoli Cell Tumor</classLabel>
<deletedAxiom>&apos;Malignant Sertoli Cell Tumor&apos; EquivalentTo &apos;Sertoli Cell Tumor&apos; and (&apos;Disease_May_Have_Finding&apos; some &apos;Metastatic Lesion&apos;)</deletedAxiom>
<newAxiom>&apos;Malignant Sertoli Cell Tumor&apos; EquivalentTo &apos;Sertoli Cell Tumor&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Increased Mitotic Activity&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Necrotic Change&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Pleomorphism&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Metastatic Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116735</classIRI>
<classLabel>Fluorine F 18 L-glutamate Derivative BAY94-9392</classLabel>
<deletedAxiom>&apos;Fluorine F 18 L-glutamate Derivative BAY94-9392&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Fluorine F 18 L-glutamate Derivative BAY94-9392&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C92187</classIRI>
<classLabel>Pericardial Adenomatoid Tumor</classLabel>
<deletedAxiom>&apos;Pericardial Adenomatoid Tumor&apos; EquivalentTo &apos;Adenomatoid Tumor&apos; and &apos;Pericardial Mesothelioma&apos; and &apos;Benign Pericardial Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Pericardial Adenomatoid Tumor&apos; SubClassOf &apos;Neoplasm by Obsolete Classification&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67299</classIRI>
<classLabel>VAC Regimen</classLabel>
<newAxiom>&apos;VAC Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Germ Cell Tumor&apos;</newAxiom>
<newAxiom>&apos;VAC Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Ovarian Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189547</classIRI>
<classLabel>SARS-CoV-2 Nucleocapsid Protein Antigen Measurement</classLabel>
<deletedAxiom>&apos;SARS-CoV-2 Nucleocapsid Protein Antigen Measurement&apos; SubClassOf &apos;Immunology Test&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141583</classIRI>
<classLabel>Shortness of Breath Visual Analogue Scale</classLabel>
<deletedAxiom>&apos;Shortness of Breath Visual Analogue Scale&apos; SubClassOf &apos;Research or Clinical Assessment Tool&apos;</deletedAxiom>
<newAxiom>&apos;Shortness of Breath Visual Analogue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141571</classIRI>
<classLabel>Lack of Appetite Visual Analogue Scale</classLabel>
<deletedAxiom>&apos;Lack of Appetite Visual Analogue Scale&apos; SubClassOf &apos;Research or Clinical Assessment Tool&apos;</deletedAxiom>
<newAxiom>&apos;Lack of Appetite Visual Analogue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141595</classIRI>
<classLabel>Depression Visual Analogue Scale</classLabel>
<deletedAxiom>&apos;Depression Visual Analogue Scale&apos; SubClassOf &apos;Research or Clinical Assessment Tool&apos;</deletedAxiom>
<newAxiom>&apos;Depression Visual Analogue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116534</classIRI>
<classLabel>EGFR Tyrosine Kinase Inhibitor Therapy</classLabel>
<newAxiom>&apos;EGFR Tyrosine Kinase Inhibitor Therapy&apos; SubClassOf &apos;Targeted Molecular Therapy&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9573</classIRI>
<classLabel>CVP Regimen</classLabel>
<deletedAxiom>&apos;CVP Regimen&apos; SubClassOf &apos;Chemotherapy_Regimen_Has_Component&apos; some &apos;Vincristine&apos;</deletedAxiom>
<newAxiom>&apos;CVP Regimen&apos; SubClassOf &apos;Chemotherapy_Regimen_Has_Component&apos; some &apos;Vincristine Sulfate&apos;</newAxiom>
<newAxiom>&apos;CVP Regimen&apos; SubClassOf &apos;Regimen Used to Treat Lymphocytic Neoplasm&apos;</newAxiom>
<newAxiom>&apos;CVP Regimen&apos; SubClassOf &apos;Regimen Used to Treat Castleman disease&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141545</classIRI>
<classLabel>Drowsiness Visual Analogue Scale</classLabel>
<deletedAxiom>&apos;Drowsiness Visual Analogue Scale&apos; SubClassOf &apos;Research or Clinical Assessment Tool&apos;</deletedAxiom>
<newAxiom>&apos;Drowsiness Visual Analogue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141533</classIRI>
<classLabel>Tiredness Visual Analogue Scale</classLabel>
<deletedAxiom>&apos;Tiredness Visual Analogue Scale&apos; SubClassOf &apos;Research or Clinical Assessment Tool&apos;</deletedAxiom>
<newAxiom>&apos;Tiredness Visual Analogue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9549</classIRI>
<classLabel>CHOP Regimen</classLabel>
<newAxiom>&apos;CHOP Regimen&apos; SubClassOf &apos;Regimen Used to Treat Lymphocytic Neoplasm&apos;</newAxiom>
<newAxiom>&apos;CHOP Regimen&apos; SubClassOf &apos;Regimen Used to Treat Hodgkin Lymphoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141559</classIRI>
<classLabel>Nausea Visual Analogue Scale</classLabel>
<deletedAxiom>&apos;Nausea Visual Analogue Scale&apos; SubClassOf &apos;Research or Clinical Assessment Tool&apos;</deletedAxiom>
<newAxiom>&apos;Nausea Visual Analogue Scale&apos; SubClassOf &apos;Visual Analog Scale&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141506</classIRI>
<classLabel>Capecitabine/Cisplatin Regimen</classLabel>
<newAxiom>&apos;Capecitabine/Cisplatin Regimen&apos; SubClassOf &apos;Regimen Used to Treat Esophageal Carcinoma&apos;</newAxiom>
<newAxiom>&apos;Capecitabine/Cisplatin Regimen&apos; SubClassOf &apos;Regimen Used to Treat Hepatobiliary Cancer&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116356</classIRI>
<classLabel>Fluorine F 18-AV-133</classLabel>
<deletedAxiom>&apos;Fluorine F 18-AV-133&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Fluorine F 18-AV-133&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C155938</classIRI>
<classLabel>Recurrent Digestive System Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Recurrent Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Recurrent Neuroendocrine Carcinoma&apos; and &apos;Recurrent Digestive System Neuroendocrine Neoplasm&apos; and &apos;Recurrent Digestive System Carcinoma&apos; and &apos;Digestive System Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Recurrent Digestive System Neuroendocrine Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191978 and &apos;Recurrent Digestive System Carcinoma&apos; and &apos;Digestive System Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C155937</classIRI>
<classLabel>Refractory Digestive System Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Refractory Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Refractory Digestive System Carcinoma&apos; and &apos;Refractory Digestive System Neuroendocrine Neoplasm&apos; and &apos;Refractory Neuroendocrine Carcinoma&apos; and &apos;Digestive System Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Refractory Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Refractory Digestive System Carcinoma&apos; and &apos;Refractory Digestive System Neuroendocrine Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191979 and &apos;Digestive System Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C155936</classIRI>
<classLabel>Metastatic Digestive System Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Metastatic Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Metastatic Digestive System Carcinoma&apos; and &apos;Metastatic Neuroendocrine Carcinoma&apos; and &apos;Metastatic Digestive System Neuroendocrine Neoplasm&apos; and &apos;Digestive System Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Metastatic Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Metastatic Digestive System Carcinoma&apos; and &apos;Metastatic Digestive System Neuroendocrine Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191981 and &apos;Digestive System Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C155935</classIRI>
<classLabel>Unresectable Digestive System Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Unresectable Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Unresectable Digestive System Carcinoma&apos; and &apos;Unresectable Digestive System Neuroendocrine Neoplasm&apos; and &apos;Unresectable Neuroendocrine Carcinoma&apos; and &apos;Digestive System Neuroendocrine Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Unresectable Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Unresectable Digestive System Carcinoma&apos; and &apos;Unresectable Digestive System Neuroendocrine Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191980 and &apos;Digestive System Neuroendocrine Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C155934</classIRI>
<classLabel>Locally Advanced Digestive System Neuroendocrine Carcinoma</classLabel>
<deletedAxiom>&apos;Locally Advanced Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Locally Advanced Digestive System Carcinoma&apos; and &apos;Metastatic Digestive System Neuroendocrine Carcinoma&apos; and &apos;Locally Advanced Neuroendocrine Carcinoma&apos; and &apos;Locally Advanced Digestive System Neuroendocrine Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Locally Advanced Digestive System Neuroendocrine Carcinoma&apos; EquivalentTo &apos;Locally Advanced Digestive System Carcinoma&apos; and &apos;Metastatic Digestive System Neuroendocrine Carcinoma&apos; and &apos;Locally Advanced Digestive System Neuroendocrine Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191983</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116324</classIRI>
<classLabel>Antifungal Agent F901318</classLabel>
<deletedAxiom>&apos;Antifungal Agent F901318&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Antifungal Agent F901318&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C141051</classIRI>
<classLabel>Multigated Acquisition Scan</classLabel>
<deletedAxiom>&apos;Multigated Acquisition Scan&apos; SubClassOf &apos;Retired Concept Current Year&apos;</deletedAxiom>
<newAxiom>&apos;Multigated Acquisition Scan&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189055</classIRI>
<classLabel>Postpubertal-Type Teratoma</classLabel>
<deletedAxiom>&apos;Postpubertal-Type Teratoma&apos; EquivalentTo &apos;Malignant Teratoma&apos; and (&apos;Disease_Has_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 12p&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Cytologic Atypia&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Prepubertal-Type Lesion&apos;)</deletedAxiom>
<newAxiom>&apos;Postpubertal-Type Teratoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189054</classIRI>
<classLabel>Prepubertal-Type Testicular Teratoma</classLabel>
<deletedAxiom>&apos;Prepubertal-Type Testicular Teratoma&apos; EquivalentTo &apos;Testicular Teratoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Prepubertal-Type Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Indolent Clinical Course&apos;) and (&apos;Disease_Excludes_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 12&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Cytologic Atypia&apos;)</deletedAxiom>
<newAxiom>&apos;Prepubertal-Type Testicular Teratoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189074</classIRI>
<classLabel>Actin, Alpha Cardiac Muscle 1</classLabel>
<deletedAxiom>&apos;Actin, Alpha Cardiac Muscle 1&apos; EquivalentTo &apos;Actin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dilated Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypertrophic Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoskeleton&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Myogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACTC1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Actin, Alpha Cardiac Muscle 1&apos; EquivalentTo &apos;Actin&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Cardiac Muscle Contraction Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Dilated Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hypertrophic Cardiomyopathy Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoskeleton&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Motility&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Myogenesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cytoskeletal Modeling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cardiac Muscle Contraction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;ACTC1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189072</classIRI>
<classLabel>ACTC1 Gene</classLabel>
<newAxiom>&apos;ACTC1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Cardiac Muscle Contraction&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189061</classIRI>
<classLabel>Anti-CD27 Monoclonal Antibody GEN1053/BNT313</classLabel>
<deletedAxiom>&apos;Anti-CD27 Monoclonal Antibody GEN1053/BNT313&apos; SubClassOf &apos;Antineoplastic Antibody&apos;</deletedAxiom>
<deletedAxiom>&apos;Anti-CD27 Monoclonal Antibody GEN1053/BNT313&apos; SubClassOf &apos;Bispecific Monoclonal Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Anti-CD27 Monoclonal Antibody GEN1053/BNT313&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192186</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189057</classIRI>
<classLabel>Postpubertal-Type Testicular Teratoma</classLabel>
<deletedAxiom>&apos;Postpubertal-Type Testicular Teratoma&apos; EquivalentTo &apos;Postpubertal-Type Teratoma&apos; and &apos;Testicular Teratoma&apos; and &apos;Malignant Testicular Germ Cell Tumor&apos; and (&apos;Disease_Has_Associated_Disease&apos; some &apos;Testicular Intratubular Germ Cell Neoplasia&apos;)</deletedAxiom>
<newAxiom>&apos;Postpubertal-Type Testicular Teratoma&apos; EquivalentTo &apos;Testicular Teratoma&apos; and &apos;Malignant Testicular Germ Cell Tumor&apos; and (&apos;Disease_Has_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 12p&apos;) and (&apos;Disease_Has_Associated_Disease&apos; some &apos;Testicular Intratubular Germ Cell Neoplasia&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Prepubertal-Type Lesion&apos;)</newAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191999</classIRI>
<classLabel>ARHGAP24 wt Allele</classLabel>
<newAxiom>'ARHGAP24 wt Allele' SubClassOf 'ARHGAP24 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191996</classIRI>
<classLabel>AP-4 Complex Subunit Mu-1</classLabel>
<newAxiom>'AP-4 Complex Subunit Mu-1' EquivalentTo 'Transport Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'Lysosome Assembly Pathway') and ('Gene_Product_Has_Chemical_Classification' some 'Scaffolding Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Exosome') and ('Gene_Product_Has_Associated_Anatomy' some 'Golgi Apparatus') and ('Gene_Product_Has_Associated_Anatomy' some 'Early Endosome') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Protein-Protein Interaction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Subcellular Protein Targeting') and ('Gene_Product_Encoded_By_Gene' some 'AP4M1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191995</classIRI>
<classLabel>AP4M1 wt Allele</classLabel>
<newAxiom>'AP4M1 wt Allele' EquivalentTo 'AP4M1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Lysosome Assembly Pathway') and ('Gene_In_Chromosomal_Location' some '7q22.1')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191998</classIRI>
<classLabel>ARHGAP24 Gene</classLabel>
<newAxiom>'ARHGAP24 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cytoskeletal Modeling'</newAxiom>
<newAxiom>'ARHGAP24 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Angiogenic Process'</newAxiom>
<newAxiom>'ARHGAP24 Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191997</classIRI>
<classLabel>Refractory Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Refractory Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Refractory Neuroendocrine Carcinoma' and 'Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191992</classIRI>
<classLabel>Locally Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Locally Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma' EquivalentTo 'Locally Advanced Small Cell Neuroendocrine Carcinoma' and 'Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma' and 'Locally Advanced Extrapulmonary Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191991</classIRI>
<classLabel>Locally Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Locally Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Locally Advanced Large Cell Neuroendocrine Carcinoma' and 'Locally Advanced Extrapulmonary Neuroendocrine Carcinoma' and 'Metastatic Extrapulmonary Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191994</classIRI>
<classLabel>AP4M1 Gene</classLabel>
<newAxiom>'AP4M1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Subcellular Protein Targeting'</newAxiom>
<newAxiom>'AP4M1 Gene' SubClassOf 'Trafficking Protein Gene'</newAxiom>
<newAxiom>'AP4M1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Protein-Protein Interaction'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191993</classIRI>
<classLabel>Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Advanced Extrapulmonary Small Cell Neuroendocrine Carcinoma' EquivalentTo 'Metastatic Extrapulmonary Small Cell Neuroendocrine Carcinoma' and 'Advanced Extrapulmonary Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191990</classIRI>
<classLabel>Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Advanced Extrapulmonary Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Advanced Large Cell Neuroendocrine Carcinoma' and 'Advanced Extrapulmonary Neuroendocrine Carcinoma' and 'Metastatic Extrapulmonary Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191989</classIRI>
<classLabel>Ontology for Biobanking</classLabel>
<newAxiom>'Ontology for Biobanking' SubClassOf 'Ontology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191988</classIRI>
<classLabel>Metastatic Extrapulmonary Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Metastatic Extrapulmonary Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Metastatic Large Cell Neuroendocrine Carcinoma' and 'Metastatic Extrapulmonary Neuroendocrine Carcinoma' and 'Extrapulmonary Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191985</classIRI>
<classLabel>Recurrent Extrapulmonary Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Recurrent Extrapulmonary Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Recurrent Extrapulmonary Neuroendocrine Carcinoma' and 'Extrapulmonary Large Cell Neuroendocrine Carcinoma' and 'Recurrent Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191984</classIRI>
<classLabel>Extrapulmonary Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Extrapulmonary Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Extrapulmonary Neuroendocrine Carcinoma' and 'Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191987</classIRI>
<classLabel>Unresectable Extrapulmonary Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Unresectable Extrapulmonary Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Unresectable Large Cell Neuroendocrine Carcinoma' and 'Unresectable Extrapulmonary Neuroendocrine Carcinoma' and 'Extrapulmonary Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191986</classIRI>
<classLabel>Refractory Extrapulmonary Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Refractory Extrapulmonary Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Refractory Extrapulmonary Neuroendocrine Carcinoma' and 'Extrapulmonary Large Cell Neuroendocrine Carcinoma' and 'Refractory Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191981</classIRI>
<classLabel>Metastatic Extrapulmonary Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Metastatic Extrapulmonary Neuroendocrine Carcinoma' EquivalentTo 'Metastatic Neuroendocrine Carcinoma' and 'Extrapulmonary Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191980</classIRI>
<classLabel>Unresectable Extrapulmonary Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Unresectable Extrapulmonary Neuroendocrine Carcinoma' EquivalentTo 'Unresectable Neuroendocrine Carcinoma' and 'Extrapulmonary Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191983</classIRI>
<classLabel>Locally Advanced Extrapulmonary Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Locally Advanced Extrapulmonary Neuroendocrine Carcinoma' EquivalentTo 'Locally Advanced Neuroendocrine Carcinoma' and 'Metastatic Extrapulmonary Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191982</classIRI>
<classLabel>Advanced Extrapulmonary Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Advanced Extrapulmonary Neuroendocrine Carcinoma' EquivalentTo 'Advanced Neuroendocrine Carcinoma' and 'Metastatic Extrapulmonary Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191978</classIRI>
<classLabel>Recurrent Extrapulmonary Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Recurrent Extrapulmonary Neuroendocrine Carcinoma' EquivalentTo 'Recurrent Neuroendocrine Carcinoma' and 'Extrapulmonary Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191977</classIRI>
<classLabel>Extrapulmonary Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Extrapulmonary Neuroendocrine Carcinoma' EquivalentTo 'Neuroendocrine Carcinoma' and ('Disease_Excludes_Primary_Anatomic_Site' some 'Lung')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191979</classIRI>
<classLabel>Refractory Extrapulmonary Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Refractory Extrapulmonary Neuroendocrine Carcinoma' EquivalentTo 'Refractory Neuroendocrine Carcinoma' and 'Extrapulmonary Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191974</classIRI>
<classLabel>SARS Coronavirus 2 BA.5.2.6</classLabel>
<newAxiom>'SARS Coronavirus 2 BA.5.2.6' SubClassOf 'SARS Coronavirus 2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191973</classIRI>
<classLabel>SARS Coronavirus 2 BN.1</classLabel>
<newAxiom>'SARS Coronavirus 2 BN.1' SubClassOf 'SARS Coronavirus 2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191976</classIRI>
<classLabel>Lipoteichoic Acid</classLabel>
<newAxiom>'Lipoteichoic Acid' SubClassOf 'Lipid'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191975</classIRI>
<classLabel>SARS Coronavirus 2 BF.11</classLabel>
<newAxiom>'SARS Coronavirus 2 BF.11' SubClassOf 'SARS Coronavirus 2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191970</classIRI>
<classLabel>CD14 Gene Product</classLabel>
<newAxiom>'CD14 Gene Product' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'CD14 Gene'</newAxiom>
<newAxiom>'CD14 Gene Product' SubClassOf 'Transport Protein'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191972</classIRI>
<classLabel>SARS Coronavirus 2 XBB.1.5</classLabel>
<newAxiom>'SARS Coronavirus 2 XBB.1.5' SubClassOf 'SARS Coronavirus 2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191971</classIRI>
<classLabel>Soluble Monocyte Differentiation Antigen CD14</classLabel>
<newAxiom>'Soluble Monocyte Differentiation Antigen CD14' EquivalentTo 'CD14 Gene Product' and ('Gene_Product_Is_Biomarker_Type' some 'Cluster of Differentiation') and ('Gene_Product_Has_Chemical_Classification' some 'Glycoprotein') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Leucine-Rich Repeat') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Myeloid Cell Activation Process') and ('Gene_Product_Encoded_By_Gene' some 'CD14 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191967</classIRI>
<classLabel>AP4B1 Gene</classLabel>
<newAxiom>'AP4B1 Gene' SubClassOf 'Trafficking Protein Gene'</newAxiom>
<newAxiom>'AP4B1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Subcellular Protein Targeting'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191966</classIRI>
<classLabel>Annexin A11</classLabel>
<newAxiom>'Annexin A11' EquivalentTo 'Ligand Binding Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'Amyotrophic Lateral Sclerosis Pathway') and ('Gene_Product_Has_Biochemical_Function' some 'Annexin Family Protein') and ('Gene_Product_Has_Biochemical_Function' some 'Calcium Binding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cytokinesis') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Protein-Protein Interaction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Calcium Binding') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Phospholipid Binding') and ('Gene_Product_Encoded_By_Gene' some 'ANXA11 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191969</classIRI>
<classLabel>AP-4 Complex Subunit Beta-1</classLabel>
<newAxiom>'AP-4 Complex Subunit Beta-1' EquivalentTo 'Transport Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'Lysosome Assembly Pathway') and ('Gene_Product_Has_Chemical_Classification' some 'Scaffolding Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Golgi Apparatus') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Armadillo Repeat') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Subcellular Protein Targeting') and ('Gene_Product_Encoded_By_Gene' some 'AP4B1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191968</classIRI>
<classLabel>AP4B1 wt Allele</classLabel>
<newAxiom>'AP4B1 wt Allele' EquivalentTo 'AP4B1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Lysosome Assembly Pathway') and ('Gene_In_Chromosomal_Location' some '1p13.2')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191963</classIRI>
<classLabel>Treatment-Related Prostate Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Treatment-Related Prostate Neuroendocrine Carcinoma' EquivalentTo 'Prostate Neuroendocrine Carcinoma' and 'Therapy-Related Malignant Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191962</classIRI>
<classLabel>Large Malignant Glands Lined with Pseudostratified Epithelium Present</classLabel>
<newAxiom>'Large Malignant Glands Lined with Pseudostratified Epithelium Present' SubClassOf 'Epithelial Component Present'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191965</classIRI>
<classLabel>ANXA11 wt Allele</classLabel>
<newAxiom>'ANXA11 wt Allele' EquivalentTo 'ANXA11 Gene' and ('Gene_Is_Element_In_Pathway' some 'Amyotrophic Lateral Sclerosis Pathway') and ('Gene_In_Chromosomal_Location' some '10q22.3')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191964</classIRI>
<classLabel>ANXA11 Gene</classLabel>
<newAxiom>'ANXA11 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Calcium Binding'</newAxiom>
<newAxiom>'ANXA11 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cytokinesis'</newAxiom>
<newAxiom>'ANXA11 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Phospholipid Binding'</newAxiom>
<newAxiom>'ANXA11 Gene' SubClassOf 'Ligand Binding Protein Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191961</classIRI>
<classLabel>Prostatic Intraepithelial Neoplasia-Like Adenocarcinoma</classLabel>
<newAxiom>'Prostatic Intraepithelial Neoplasia-Like Adenocarcinoma' EquivalentTo 'Prostate Acinar Adenocarcinoma' and ('Disease_Has_Finding' some 'Large Malignant Glands Lined with Pseudostratified Epithelium Present')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191960</classIRI>
<classLabel>HIV Screening</classLabel>
<newAxiom>'HIV Screening' SubClassOf 'Viral Screening'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191959</classIRI>
<classLabel>Circulating Tumor HPV DNA</classLabel>
<newAxiom>'Circulating Tumor HPV DNA' SubClassOf 'Circulating Tumor-Derived DNA'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191956</classIRI>
<classLabel>PD-L1 Inhibitor INCB099318</classLabel>
<newAxiom>'PD-L1 Inhibitor INCB099318' SubClassOf 'PD-L1 Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191955</classIRI>
<classLabel>Anti-LILRB2 Monoclonal Antibody BMS-986406</classLabel>
<newAxiom>'Anti-LILRB2 Monoclonal Antibody BMS-986406' SubClassOf 'Immune Checkpoint Inhibitor'</newAxiom>
<newAxiom>'Anti-LILRB2 Monoclonal Antibody BMS-986406' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-LILRB2 Monoclonal Antibody BMS-986406' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191958</classIRI>
<classLabel>Activating ESR1 Gene Mutation</classLabel>
<newAxiom>'Activating ESR1 Gene Mutation' SubClassOf 'Gain of Function Gene Mutation'</newAxiom>
<newAxiom>'Activating ESR1 Gene Mutation' SubClassOf 'ESR1 Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191957</classIRI>
<classLabel>PI3K/mTOR Inhibitor CLL442</classLabel>
<newAxiom>'PI3K/mTOR Inhibitor CLL442' SubClassOf 'Phosphatidylinositide 3-Kinase Inhibitor'</newAxiom>
<newAxiom>'PI3K/mTOR Inhibitor CLL442' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191952</classIRI>
<classLabel>DPYD NP_000101.2:p.Y186C</classLabel>
<newAxiom>'DPYD NP_000101.2:p.Y186C' SubClassOf 'DPYD Protein Variant'</newAxiom>
<newAxiom>'DPYD NP_000101.2:p.Y186C' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'DPYD NM_000110.4:c.557AG'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191951</classIRI>
<classLabel>Central Review</classLabel>
<newAxiom>'Central Review' SubClassOf 'Review'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191954</classIRI>
<classLabel>Tuvonralimab</classLabel>
<newAxiom>'Tuvonralimab' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Tuvonralimab' SubClassOf 'Anti-CTLA-4 Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191953</classIRI>
<classLabel>BRAF Inhibitor PF-07799933</classLabel>
<newAxiom>'BRAF Inhibitor PF-07799933' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'Positive Regulation of Apoptosis'</newAxiom>
<newAxiom>'BRAF Inhibitor PF-07799933' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'Inhibition of Cell Proliferation'</newAxiom>
<newAxiom>'BRAF Inhibitor PF-07799933' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'BRAF Inhibitor PF-07799933' SubClassOf 'BRAF Inhibitor'</newAxiom>
<newAxiom>'BRAF Inhibitor PF-07799933' SubClassOf 'Chemical_Or_Drug_Has_Mechanism_Of_Action' some 'Enzyme Inhibition'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191950</classIRI>
<classLabel>DPYD NP_000101.2:p.D949V</classLabel>
<newAxiom>'DPYD NP_000101.2:p.D949V' SubClassOf 'DPYD Protein Variant'</newAxiom>
<newAxiom>'DPYD NP_000101.2:p.D949V' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'DPYD NM_000110.4:c.2846AT'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191949</classIRI>
<classLabel>DPYD NP_000101.2:p.I560S</classLabel>
<newAxiom>'DPYD NP_000101.2:p.I560S' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'DPYD NM_000110.4:c.1679TG'</newAxiom>
<newAxiom>'DPYD NP_000101.2:p.I560S' SubClassOf 'DPYD Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191948</classIRI>
<classLabel>Deleterious SPOP Gene Mutation</classLabel>
<newAxiom>'Deleterious SPOP Gene Mutation' SubClassOf 'SPOP Gene Mutation'</newAxiom>
<newAxiom>'Deleterious SPOP Gene Mutation' SubClassOf 'Deleterious Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191945</classIRI>
<classLabel>Infertility Related to Medical Condition</classLabel>
<newAxiom>'Infertility Related to Medical Condition' SubClassOf 'Infertility'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191944</classIRI>
<classLabel>DPYD NM_000110.4:c.557AG</classLabel>
<newAxiom>'DPYD NM_000110.4:c.557AG' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'DPYD NP_000101.2:p.Y186C'</newAxiom>
<newAxiom>'DPYD NM_000110.4:c.557AG' SubClassOf 'DPYD Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191947</classIRI>
<classLabel>SPOP Gene Mutation</classLabel>
<newAxiom>'SPOP Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'SPOP Gene'</newAxiom>
<newAxiom>'SPOP Gene Mutation' SubClassOf 'Gene Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191946</classIRI>
<classLabel>Infertility Related to Treatment</classLabel>
<newAxiom>'Infertility Related to Treatment' SubClassOf 'Infertility'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191941</classIRI>
<classLabel>DPYD NM_000110.4:c.1679TG</classLabel>
<newAxiom>'DPYD NM_000110.4:c.1679TG' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'DPYD NP_000101.2:p.I560S'</newAxiom>
<newAxiom>'DPYD NM_000110.4:c.1679TG' SubClassOf 'DPYD Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191940</classIRI>
<classLabel>DPYD NM_000110.4:c.1905+1GA</classLabel>
<newAxiom>'DPYD NM_000110.4:c.1905+1GA' SubClassOf 'Intron Splice Region Mutation'</newAxiom>
<newAxiom>'DPYD NM_000110.4:c.1905+1GA' SubClassOf 'DPYD Exon 14 Skipping Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191943</classIRI>
<classLabel>DPYD NM_000110.4:c.2846AT</classLabel>
<newAxiom>'DPYD NM_000110.4:c.2846AT' SubClassOf 'DPYD Gene Mutation'</newAxiom>
<newAxiom>'DPYD NM_000110.4:c.2846AT' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'DPYD NP_000101.2:p.D949V'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191942</classIRI>
<classLabel>DPYD NM_000110.4:c.1236GA</classLabel>
<newAxiom>'DPYD NM_000110.4:c.1236GA' SubClassOf 'Silent Mutation'</newAxiom>
<newAxiom>'DPYD NM_000110.4:c.1236GA' SubClassOf 'DPYD Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191938</classIRI>
<classLabel>Last Known Disease Status</classLabel>
<newAxiom>'Last Known Disease Status' SubClassOf 'Medical Status'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191937</classIRI>
<classLabel>Basecalling</classLabel>
<newAxiom>'Basecalling' SubClassOf 'Sequence Analysis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191939</classIRI>
<classLabel>DPYD Exon 14 Skipping Mutation</classLabel>
<newAxiom>'DPYD Exon 14 Skipping Mutation' SubClassOf 'Exon Skipping Mutation'</newAxiom>
<newAxiom>'DPYD Exon 14 Skipping Mutation' SubClassOf 'DPYD Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191934</classIRI>
<classLabel>Pericardial Constriction</classLabel>
<newAxiom>'Pericardial Constriction' SubClassOf 'Cardiovascular System Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191933</classIRI>
<classLabel>Medical Abortion</classLabel>
<newAxiom>'Medical Abortion' SubClassOf 'Induced Abortion Procedure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191935</classIRI>
<classLabel>Balloon Catheter</classLabel>
<newAxiom>'Balloon Catheter' SubClassOf 'Catheter Device'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191930</classIRI>
<classLabel>AMPD1 wt Allele</classLabel>
<newAxiom>'AMPD1 wt Allele' EquivalentTo 'AMPD1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Purine Metabolism Pathway') and ('Gene_In_Chromosomal_Location' some '1p13.2')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191932</classIRI>
<classLabel>Nebotermin</classLabel>
<newAxiom>'Nebotermin' SubClassOf 'Agent Affecting Musculoskeletal System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191931</classIRI>
<classLabel>AMP Deaminase 1</classLabel>
<newAxiom>'AMP Deaminase 1' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'AMPD1 Gene'</newAxiom>
<newAxiom>'AMP Deaminase 1' SubClassOf 'Gene_Product_Expressed_In_Tissue' some 'Skeletal Muscle Tissue'</newAxiom>
<newAxiom>'AMP Deaminase 1' SubClassOf 'Hydrolase'</newAxiom>
<newAxiom>'AMP Deaminase 1' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Energy Metabolism Process'</newAxiom>
<newAxiom>'AMP Deaminase 1' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Nucleotide Metabolic Process'</newAxiom>
<newAxiom>'AMP Deaminase 1' SubClassOf 'Gene_Product_Is_Element_In_Pathway' some 'Purine Metabolism Pathway'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191927</classIRI>
<classLabel>ALX3 wt Allele</classLabel>
<newAxiom>'ALX3 wt Allele' SubClassOf 'ALX3 Gene'</newAxiom>
<newAxiom>'ALX3 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '1p13.3'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191926</classIRI>
<classLabel>ALX3 Gene</classLabel>
<newAxiom>'ALX3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Skeletal Development'</newAxiom>
<newAxiom>'ALX3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Pattern Formation'</newAxiom>
<newAxiom>'ALX3 Gene' SubClassOf 'Homeobox Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191929</classIRI>
<classLabel>AMPD1 Gene</classLabel>
<newAxiom>'AMPD1 Gene' SubClassOf 'Hydrolase Gene'</newAxiom>
<newAxiom>'AMPD1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Nucleotide Metabolic Process'</newAxiom>
<newAxiom>'AMPD1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Energy Metabolism Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191928</classIRI>
<classLabel>Homeobox Protein Aristaless-Like 3</classLabel>
<newAxiom>'Homeobox Protein Aristaless-Like 3' EquivalentTo 'Transcription Factor' and ('Gene_Product_Has_Chemical_Classification' some 'Homeobox Family Protein') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Homeo Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Proline-Rich Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Sequence-Specific DNA Binding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Pattern Formation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Skeletal Development') and ('Gene_Product_Encoded_By_Gene' some 'ALX3 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191923</classIRI>
<classLabel>Centrosome-Associated Protein ALMS1</classLabel>
<newAxiom>'Centrosome-Associated Protein ALMS1' EquivalentTo 'Transport Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Centrosome') and ('Gene_Product_Has_Associated_Anatomy' some 'Cilium') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Intracellular Transport') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Microtubule Process') and ('Gene_Product_Encoded_By_Gene' some 'ALMS1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191922</classIRI>
<classLabel>ALMS1 wt Allele</classLabel>
<newAxiom>'ALMS1 wt Allele' SubClassOf 'ALMS1 Gene'</newAxiom>
<newAxiom>'ALMS1 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '2p13.1'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191925</classIRI>
<classLabel>Etoposide/Valganciclovir Regimen</classLabel>
<newAxiom>'Etoposide/Valganciclovir Regimen' SubClassOf 'Regimen Used to Treat Castleman disease'</newAxiom>
<newAxiom>'Etoposide/Valganciclovir Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Etoposide'</newAxiom>
<newAxiom>'Etoposide/Valganciclovir Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Valganciclovir Hydrochloride'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191924</classIRI>
<classLabel>Etoposide/Ganciclovir Regimen</classLabel>
<newAxiom>'Etoposide/Ganciclovir Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Etoposide'</newAxiom>
<newAxiom>'Etoposide/Ganciclovir Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Ganciclovir Sodium'</newAxiom>
<newAxiom>'Etoposide/Ganciclovir Regimen' SubClassOf 'Regimen Used to Treat Castleman disease'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191921</classIRI>
<classLabel>ALMS1 Gene</classLabel>
<newAxiom>'ALMS1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Microtubule Process'</newAxiom>
<newAxiom>'ALMS1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Intracellular Transport'</newAxiom>
<newAxiom>'ALMS1 Gene' SubClassOf 'Transport Protein Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191920</classIRI>
<classLabel>Valganciclovir/Vinblastine Regimen</classLabel>
<newAxiom>'Valganciclovir/Vinblastine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Valganciclovir Hydrochloride'</newAxiom>
<newAxiom>'Valganciclovir/Vinblastine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vinblastine Sulfate'</newAxiom>
<newAxiom>'Valganciclovir/Vinblastine Regimen' SubClassOf 'Regimen Used to Treat Castleman disease'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191919</classIRI>
<classLabel>Ganciclovir/Vinblastine Regimen</classLabel>
<newAxiom>'Ganciclovir/Vinblastine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Ganciclovir Sodium'</newAxiom>
<newAxiom>'Ganciclovir/Vinblastine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vinblastine Sulfate'</newAxiom>
<newAxiom>'Ganciclovir/Vinblastine Regimen' SubClassOf 'Regimen Used to Treat Castleman disease'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191916</classIRI>
<classLabel>Liposomal Doxorubicin/Valganciclovir Regimen</classLabel>
<newAxiom>'Liposomal Doxorubicin/Valganciclovir Regimen' SubClassOf 'Regimen Used to Treat Castleman disease'</newAxiom>
<newAxiom>'Liposomal Doxorubicin/Valganciclovir Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Valganciclovir Hydrochloride'</newAxiom>
<newAxiom>'Liposomal Doxorubicin/Valganciclovir Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegylated Liposomal Doxorubicin Hydrochloride'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191915</classIRI>
<classLabel>PVR Positive</classLabel>
<newAxiom>'PVR Positive' SubClassOf 'Expression Positive'</newAxiom>
<newAxiom>'PVR Positive' SubClassOf 'Receptor Status'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191918</classIRI>
<classLabel>Valganciclovir/High-dose Zidovudine Regimen</classLabel>
<newAxiom>'Valganciclovir/High-dose Zidovudine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Zidovudine'</newAxiom>
<newAxiom>'Valganciclovir/High-dose Zidovudine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Valganciclovir Hydrochloride'</newAxiom>
<newAxiom>'Valganciclovir/High-dose Zidovudine Regimen' SubClassOf 'Regimen Used to Treat Castleman disease'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191917</classIRI>
<classLabel>Ganciclovir/High-dose Zidovudine Regimen</classLabel>
<newAxiom>'Ganciclovir/High-dose Zidovudine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Ganciclovir Sodium'</newAxiom>
<newAxiom>'Ganciclovir/High-dose Zidovudine Regimen' SubClassOf 'Regimen Used to Treat Castleman disease'</newAxiom>
<newAxiom>'Ganciclovir/High-dose Zidovudine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Zidovudine'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191912</classIRI>
<classLabel>Cisplatin/Cyclophosphamide/Vincristine Regimen</classLabel>
<newAxiom>'Cisplatin/Cyclophosphamide/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
<newAxiom>'Cisplatin/Cyclophosphamide/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Malignant Brain Neoplasm'</newAxiom>
<newAxiom>'Cisplatin/Cyclophosphamide/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Cisplatin/Cyclophosphamide/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cisplatin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191911</classIRI>
<classLabel>ALAS2 wt Allele</classLabel>
<newAxiom>'ALAS2 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Porphyrin and Chlorophyll Metabolism Pathway'</newAxiom>
<newAxiom>'ALAS2 wt Allele' SubClassOf 'ALAS2 Gene'</newAxiom>
<newAxiom>'ALAS2 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Glycine, Serine and Threonine Metabolism Pathway'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191914</classIRI>
<classLabel>5-Aminolevulinate Synthase, Erythroid-Specific, Mitochondrial</classLabel>
<newAxiom>'5-Aminolevulinate Synthase, Erythroid-Specific, Mitochondrial' EquivalentTo 'Acyltransferase' and ('Gene_Product_Is_Element_In_Pathway' some 'Glycine, Serine and Threonine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Porphyrin and Chlorophyll Metabolism Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Erythrocyte') and ('Gene_Product_Has_Associated_Anatomy' some 'Inner Mitochondrial Membrane') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Biosynthetic Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Lipid Metabolic Process') and ('Gene_Product_Encoded_By_Gene' some 'ALAS2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191913</classIRI>
<classLabel>Liposomal Doxorubicin/Ganciclovir Regimen</classLabel>
<newAxiom>'Liposomal Doxorubicin/Ganciclovir Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegylated Liposomal Doxorubicin Hydrochloride'</newAxiom>
<newAxiom>'Liposomal Doxorubicin/Ganciclovir Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Ganciclovir Sodium'</newAxiom>
<newAxiom>'Liposomal Doxorubicin/Ganciclovir Regimen' SubClassOf 'Regimen Used to Treat Castleman disease'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191910</classIRI>
<classLabel>Cyclophosphamide/Cytarabine/Mercaptopurine/Pegaspargase/Vincristine Regimen</classLabel>
<newAxiom>'Cyclophosphamide/Cytarabine/Mercaptopurine/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Mercaptopurine/Pegaspargase/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Mercaptopurine/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Mercaptopurine'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Mercaptopurine/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cytarabine Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Mercaptopurine/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegaspargase'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Mercaptopurine/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191909</classIRI>
<classLabel>Paflufocon C</classLabel>
<newAxiom>'Paflufocon C' SubClassOf 'Rigid Gas Permeable Contact Lens'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191908</classIRI>
<classLabel>ALAS2 Gene</classLabel>
<newAxiom>'ALAS2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Lipid Metabolic Process'</newAxiom>
<newAxiom>'ALAS2 Gene' SubClassOf 'Transferase Gene'</newAxiom>
<newAxiom>'ALAS2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Biosynthetic Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191905</classIRI>
<classLabel>AHI1 wt Allele</classLabel>
<newAxiom>'AHI1 wt Allele' SubClassOf 'AHI1 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191904</classIRI>
<classLabel>AHI1 Gene</classLabel>
<newAxiom>'AHI1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Microtubule Process'</newAxiom>
<newAxiom>'AHI1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Nervous System Development'</newAxiom>
<newAxiom>'AHI1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Neural Development'</newAxiom>
<newAxiom>'AHI1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Intracellular Transport'</newAxiom>
<newAxiom>'AHI1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Pattern Formation'</newAxiom>
<newAxiom>'AHI1 Gene' SubClassOf 'Regulatory Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191907</classIRI>
<classLabel>Anti-CD93 Monoclonal Antibody DCSZ11</classLabel>
<newAxiom>'Anti-CD93 Monoclonal Antibody DCSZ11' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191906</classIRI>
<classLabel>Jouberin</classLabel>
<newAxiom>'Jouberin' EquivalentTo 'Regulatory Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Has_Associated_Anatomy' some 'Basal Body') and ('Gene_Product_Has_Associated_Anatomy' some 'Centriole') and ('Gene_Product_Has_Associated_Anatomy' some 'Centrosome') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'SH3 Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Coiled-Coil Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'WD Repeat') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Intracellular Transport') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Neural Development') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Pattern Formation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Nervous System Development') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Microtubule Process') and ('Gene_Product_Encoded_By_Gene' some 'AHI1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191901</classIRI>
<classLabel>COQ8B wt Allele</classLabel>
<newAxiom>'COQ8B wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '19q13.2'</newAxiom>
<newAxiom>'COQ8B wt Allele' SubClassOf 'COQ8B Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191900</classIRI>
<classLabel>COQ8B Gene</classLabel>
<newAxiom>'COQ8B Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Biosynthetic Process'</newAxiom>
<newAxiom>'COQ8B Gene' SubClassOf 'Phosphotransferase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191903</classIRI>
<classLabel>Mosunetuzumab Regimen</classLabel>
<newAxiom>'Mosunetuzumab Regimen' SubClassOf 'Regimen Used to Treat Non-Hodgkin Lymphoma'</newAxiom>
<newAxiom>'Mosunetuzumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Mosunetuzumab'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191902</classIRI>
<classLabel>Atypical Kinase COQ8B, Mitochondrial</classLabel>
<newAxiom>'Atypical Kinase COQ8B, Mitochondrial' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Biosynthetic Process'</newAxiom>
<newAxiom>'Atypical Kinase COQ8B, Mitochondrial' SubClassOf 'Phosphotransferase'</newAxiom>
<newAxiom>'Atypical Kinase COQ8B, Mitochondrial' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'COQ8B Gene'</newAxiom>
<newAxiom>'Atypical Kinase COQ8B, Mitochondrial' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Mitochondrion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191889</classIRI>
<classLabel>ACOX1 Gene</classLabel>
<newAxiom>'ACOX1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Fatty Acid Metabolism'</newAxiom>
<newAxiom>'ACOX1 Gene' SubClassOf 'Oxidoreductase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191886</classIRI>
<classLabel>AASS Gene</classLabel>
<newAxiom>'AASS Gene' SubClassOf 'Oxidoreductase Gene'</newAxiom>
<newAxiom>'AASS Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Catabolic Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191888</classIRI>
<classLabel>Alpha-Aminoadipic Semialdehyde Synthase, Mitochondrial</classLabel>
<newAxiom>'Alpha-Aminoadipic Semialdehyde Synthase, Mitochondrial' EquivalentTo 'Oxidoreductase' and ('Gene_Product_Is_Element_In_Pathway' some 'Lysine Degradation Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Mitochondrial Matrix') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Catabolic Process') and ('Gene_Product_Encoded_By_Gene' some 'AASS Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191887</classIRI>
<classLabel>AASS wt Allele</classLabel>
<newAxiom>'AASS wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Lysine Degradation Pathway'</newAxiom>
<newAxiom>'AASS wt Allele' SubClassOf 'AASS Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191897</classIRI>
<classLabel>ADAT3 Gene</classLabel>
<newAxiom>'ADAT3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Nucleotide Metabolic Process'</newAxiom>
<newAxiom>'ADAT3 Gene' SubClassOf 'Regulatory Gene'</newAxiom>
<newAxiom>'ADAT3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'RNA Processing'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191896</classIRI>
<classLabel>Actin, Alpha Skeletal Muscle</classLabel>
<newAxiom>'Actin, Alpha Skeletal Muscle' EquivalentTo 'Actin' and ('Gene_Product_Is_Element_In_Pathway' some 'Caspase Cascade in Apoptosis') and ('Gene_Product_Is_Element_In_Pathway' some 'Osteopontin-Mediated Signaling Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoskeleton') and ('Gene_Product_Has_Associated_Anatomy' some 'Sarcomere') and ('Gene_Product_Expressed_In_Tissue' some 'Skeletal Muscle Tissue') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Myogenesis') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cytoskeletal Modeling') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Muscle Contraction') and ('Gene_Product_Encoded_By_Gene' some 'ACTA1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191899</classIRI>
<classLabel>Probable Inactive tRNA-Specific Adenosine Deaminase-Like Protein 3</classLabel>
<newAxiom>'Probable Inactive tRNA-Specific Adenosine Deaminase-Like Protein 3' EquivalentTo 'Regulatory Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleoplasm') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'RNA Processing') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Nucleotide Metabolic Process') and ('Gene_Product_Encoded_By_Gene' some 'ADAT3 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191898</classIRI>
<classLabel>ADAT3 wt Allele</classLabel>
<newAxiom>'ADAT3 wt Allele' SubClassOf 'ADAT3 Gene'</newAxiom>
<newAxiom>'ADAT3 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '19p13.3'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191893</classIRI>
<classLabel>ACTA1 Gene</classLabel>
<newAxiom>'ACTA1 Gene' SubClassOf 'Microfilament Gene'</newAxiom>
<newAxiom>'ACTA1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Muscle Contraction'</newAxiom>
<newAxiom>'ACTA1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Myogenesis'</newAxiom>
<newAxiom>'ACTA1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cytoskeletal Modeling'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191892</classIRI>
<classLabel>Prior Radiation Therapy of Chest Wall</classLabel>
<newAxiom>'Prior Radiation Therapy of Chest Wall' SubClassOf 'Prior Radiation Therapy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191895</classIRI>
<classLabel>ACTA1 wt Allele</classLabel>
<newAxiom>'ACTA1 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Osteopontin-Mediated Signaling Pathway'</newAxiom>
<newAxiom>'ACTA1 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Caspase Cascade in Apoptosis'</newAxiom>
<newAxiom>'ACTA1 wt Allele' SubClassOf 'ACTA1 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191894</classIRI>
<classLabel>Prior Radiation Therapy of Thoracic Region</classLabel>
<newAxiom>'Prior Radiation Therapy of Thoracic Region' SubClassOf 'Prior Radiation Therapy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191891</classIRI>
<classLabel>Peroxisomal Acyl-Coenzyme A Oxidase 1</classLabel>
<newAxiom>'Peroxisomal Acyl-Coenzyme A Oxidase 1' EquivalentTo 'Oxidoreductase' and ('Gene_Product_Is_Element_In_Pathway' some 'Beta-Alanine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Propanoate Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'alpha-Linolenic Acid Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Biosynthesis of Unsaturated Fatty Acids Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'PPAR Signaling Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Peroxisome Biogenesis Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Lumen of the Peroxisome') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Fatty Acid Metabolism') and ('Gene_Product_Encoded_By_Gene' some 'ACOX1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191890</classIRI>
<classLabel>ACOX1 wt Allele</classLabel>
<newAxiom>'ACOX1 wt Allele' EquivalentTo 'ACOX1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Beta-Alanine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Fatty Acid Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Propanoate Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'alpha-Linolenic Acid Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Biosynthesis of Unsaturated Fatty Acids Pathway') and ('Gene_Is_Element_In_Pathway' some 'PPAR Signaling Pathway') and ('Gene_Is_Element_In_Pathway' some 'Peroxisome Biogenesis Pathway') and ('Gene_In_Chromosomal_Location' some '17q25.1')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192213</classIRI>
<classLabel>Locally Advanced Estrogen Receptor-Positive Breast Carcinoma</classLabel>
<newAxiom>'Locally Advanced Estrogen Receptor-Positive Breast Carcinoma' EquivalentTo 'Locally Advanced Hormone Receptor-Positive Breast Carcinoma' and 'Metastatic Estrogen Receptor-Positive Breast Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192211</classIRI>
<classLabel>Advanced Estrogen Receptor-Positive Breast Carcinoma</classLabel>
<newAxiom>'Advanced Estrogen Receptor-Positive Breast Carcinoma' EquivalentTo 'Advanced Hormone Receptor-Positive Breast Carcinoma' and 'Metastatic Estrogen Receptor-Positive Breast Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192212</classIRI>
<classLabel>Unresectable Estrogen Receptor-Positive Breast Carcinoma</classLabel>
<newAxiom>'Unresectable Estrogen Receptor-Positive Breast Carcinoma' EquivalentTo 'Unresectable Hormone Receptor-Positive Breast Carcinoma' and 'Estrogen Receptor-Positive Breast Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192208</classIRI>
<classLabel>Anti-TCR Vb6/Vb10/IL-2 Antibody Fusion Protein STAR0602</classLabel>
<newAxiom>'Anti-TCR Vb6/Vb10/IL-2 Antibody Fusion Protein STAR0602' SubClassOf 'Immunotherapeutic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192209</classIRI>
<classLabel>Anti-CD228/4-1BB Bispecific Agent SGN-BB228</classLabel>
<newAxiom>'Anti-CD228/4-1BB Bispecific Agent SGN-BB228' SubClassOf 'Antineoplastic Immunomodulating Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192206</classIRI>
<classLabel>Autologous Anti-Claudin18.2 CAR T-cells LB1908</classLabel>
<newAxiom>'Autologous Anti-Claudin18.2 CAR T-cells LB1908' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Autologous Anti-Claudin18.2 CAR T-cells LB1908' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Autologous Anti-Claudin18.2 CAR T-cells LB1908' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192207</classIRI>
<classLabel>Activating RAF Family Alteration Positive</classLabel>
<newAxiom>'Activating RAF Family Alteration Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192204</classIRI>
<classLabel>Resectable Gastroesophageal Junction Adenocarcinoma</classLabel>
<newAxiom>'Resectable Gastroesophageal Junction Adenocarcinoma' EquivalentTo 'Resectable Digestive System Carcinoma' and 'Gastroesophageal Junction Adenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192205</classIRI>
<classLabel>Anti-LAG-3/PD-1 Bispecific Antibody INCA32459</classLabel>
<newAxiom>'Anti-LAG-3/PD-1 Bispecific Antibody INCA32459' SubClassOf 'Anti-PD1 Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-LAG-3/PD-1 Bispecific Antibody INCA32459' SubClassOf 'Anti-LAG-3 Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-LAG-3/PD-1 Bispecific Antibody INCA32459' SubClassOf 'Bispecific Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192202</classIRI>
<classLabel>Long QT Syndrome 12</classLabel>
<newAxiom>'Long QT Syndrome 12' SubClassOf 'Long QT Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192203</classIRI>
<classLabel>Resectable Gastric Adenocarcinoma</classLabel>
<newAxiom>'Resectable Gastric Adenocarcinoma' EquivalentTo 'Resectable Digestive System Carcinoma' and 'Gastric Adenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192200</classIRI>
<classLabel>Hypochlorous Acid-containing Wound Spray APR-TD011</classLabel>
<newAxiom>'Hypochlorous Acid-containing Wound Spray APR-TD011' SubClassOf 'Agent Affecting Integumentary System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192201</classIRI>
<classLabel>Generalized Epilepsy with Febrile Seizures Plus, Type 9</classLabel>
<newAxiom>'Generalized Epilepsy with Febrile Seizures Plus, Type 9' SubClassOf 'Generalized Epilepsy with Febrile Seizures Plus'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192180</classIRI>
<classLabel>Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Pegaspargase/Prednisone/Vincristine Regimen</classLabel>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Idarubicin Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegaspargase'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Daunorubicin Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Prednisone'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cytarabine Hydrochloride'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192178</classIRI>
<classLabel>Escalated-dose BEACOPP Regimen</classLabel>
<newAxiom>'Escalated-dose BEACOPP Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Doxorubicin Hydrochloride'</newAxiom>
<newAxiom>'Escalated-dose BEACOPP Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Escalated-dose BEACOPP Regimen' SubClassOf 'Regimen Used to Treat Hodgkin Lymphoma'</newAxiom>
<newAxiom>'Escalated-dose BEACOPP Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
<newAxiom>'Escalated-dose BEACOPP Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Etoposide'</newAxiom>
<newAxiom>'Escalated-dose BEACOPP Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Prednisone'</newAxiom>
<newAxiom>'Escalated-dose BEACOPP Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Bleomycin'</newAxiom>
<newAxiom>'Escalated-dose BEACOPP Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Procarbazine Hydrochloride'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192179</classIRI>
<classLabel>Mercaptopurine/Methotrexate/Prednisone/Vincristine Regimen</classLabel>
<newAxiom>'Mercaptopurine/Methotrexate/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Mercaptopurine'</newAxiom>
<newAxiom>'Mercaptopurine/Methotrexate/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Mercaptopurine/Methotrexate/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Prednisone'</newAxiom>
<newAxiom>'Mercaptopurine/Methotrexate/Prednisone/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'Mercaptopurine/Methotrexate/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Methotrexate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192176</classIRI>
<classLabel>Purinostat</classLabel>
<newAxiom>'Purinostat' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'Purinostat' SubClassOf 'Histone Deacetylase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192177</classIRI>
<classLabel>Purinostat Mesylate</classLabel>
<newAxiom>'Purinostat Mesylate' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'Purinostat Mesylate' SubClassOf 'Histone Deacetylase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192174</classIRI>
<classLabel>Prodencel</classLabel>
<newAxiom>'Prodencel' SubClassOf 'Therapeutic Autologous Dendritic Cells'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192175</classIRI>
<classLabel>FASTA File</classLabel>
<newAxiom>'FASTA File' SubClassOf 'File'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192172</classIRI>
<classLabel>Anti-interleukin-13 Receptor Alpha 2 CAR T Cells YYB-103</classLabel>
<newAxiom>'Anti-interleukin-13 Receptor Alpha 2 CAR T Cells YYB-103' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Anti-interleukin-13 Receptor Alpha 2 CAR T Cells YYB-103' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192173</classIRI>
<classLabel>SHP2 Inhibitor ET0038</classLabel>
<newAxiom>'SHP2 Inhibitor ET0038' SubClassOf 'SHP2 Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192170</classIRI>
<classLabel>FGFR Inhibitor ET0111</classLabel>
<newAxiom>'FGFR Inhibitor ET0111' SubClassOf 'FGFR Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192171</classIRI>
<classLabel>Anti-PD-L1/TGFbetaRII Fusion Protein 6MW3511</classLabel>
<newAxiom>'Anti-PD-L1/TGFbetaRII Fusion Protein 6MW3511' SubClassOf 'Antineoplastic Immunomodulating Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192169</classIRI>
<classLabel>HMGB1 Inhibitor SB17170</classLabel>
<newAxiom>'HMGB1 Inhibitor SB17170' SubClassOf 'Antineoplastic Protein Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192167</classIRI>
<classLabel>ALDH2*1/*2 Genotype Positive</classLabel>
<newAxiom>'ALDH2*1/*2 Genotype Positive' SubClassOf 'Gene Variant Positive'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192168</classIRI>
<classLabel>TLR Agonist Decoy20</classLabel>
<newAxiom>'TLR Agonist Decoy20' SubClassOf 'Toll-like Receptor 8 Agonist'</newAxiom>
<newAxiom>'TLR Agonist Decoy20' SubClassOf 'Immunoconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192165</classIRI>
<classLabel>ALDH2 Gene Mutation Negative</classLabel>
<newAxiom>'ALDH2 Gene Mutation Negative' SubClassOf 'Wildtype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192163</classIRI>
<classLabel>ALDH2 NM_000690.4:c.1510GA</classLabel>
<newAxiom>'ALDH2 NM_000690.4:c.1510GA' SubClassOf 'ALDH2 Gene Mutation'</newAxiom>
<newAxiom>'ALDH2 NM_000690.4:c.1510GA' SubClassOf 'Loss of Function Gene Mutation'</newAxiom>
<newAxiom>'ALDH2 NM_000690.4:c.1510GA' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ALDH2 NP_000681.2:p.E504K'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192164</classIRI>
<classLabel>ALDH2 NP_000681.2:p.E504K</classLabel>
<newAxiom>'ALDH2 NP_000681.2:p.E504K' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ALDH2 NM_000690.4:c.1510GA'</newAxiom>
<newAxiom>'ALDH2 NP_000681.2:p.E504K' SubClassOf 'ALDH2 Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192161</classIRI>
<classLabel>ALDH2 Gene Mutation</classLabel>
<newAxiom>'ALDH2 Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'ALDH2 Gene'</newAxiom>
<newAxiom>'ALDH2 Gene Mutation' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ALDH2 Protein Variant'</newAxiom>
<newAxiom>'ALDH2 Gene Mutation' SubClassOf 'Gene Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192162</classIRI>
<classLabel>ALDH2 Protein Variant</classLabel>
<newAxiom>'ALDH2 Protein Variant' SubClassOf 'Gene Product Sequence Variation'</newAxiom>
<newAxiom>'ALDH2 Protein Variant' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'ALDH2 Gene'</newAxiom>
<newAxiom>'ALDH2 Protein Variant' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ALDH2 Gene Mutation'</newAxiom>
<newAxiom>'ALDH2 Protein Variant' SubClassOf 'Gene_Product_Variant_Of_Gene_Product' some 'Aldehyde Dehydrogenase, Mitochondrial'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192160</classIRI>
<classLabel>PROMIS Emotional Support Item Bank</classLabel>
<newAxiom>'PROMIS Emotional Support Item Bank' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192158</classIRI>
<classLabel>Have Someone Who Makes Me Feel Appreciated</classLabel>
<newAxiom>'Have Someone Who Makes Me Feel Appreciated' SubClassOf 'Someone There'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192159</classIRI>
<classLabel>Have Someone to Talk with When Having a Bad Day</classLabel>
<newAxiom>'Have Someone to Talk with When Having a Bad Day' SubClassOf 'Someone There'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192156</classIRI>
<classLabel>Patient Must have a Specified Item or Intervention</classLabel>
<newAxiom>'Patient Must have a Specified Item or Intervention' SubClassOf 'Risk Evaluation and Mitigation Strategies Requirement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192157</classIRI>
<classLabel>Distribute Only to Certified Healthcare Provider or Setting</classLabel>
<newAxiom>'Distribute Only to Certified Healthcare Provider or Setting' SubClassOf 'Risk Evaluation and Mitigation Strategies Requirement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192154</classIRI>
<classLabel>Provide Safe Use Conditions</classLabel>
<newAxiom>'Provide Safe Use Conditions' SubClassOf 'Risk Evaluation and Mitigation Strategies Requirement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192155</classIRI>
<classLabel>Do Not Dispense Outside of Specified Facility</classLabel>
<newAxiom>'Do Not Dispense Outside of Specified Facility' SubClassOf 'Risk Evaluation and Mitigation Strategies Requirement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192152</classIRI>
<classLabel>CAPOX-Pembrolizumab Regimen</classLabel>
<newAxiom>'CAPOX-Pembrolizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Oxaliplatin'</newAxiom>
<newAxiom>'CAPOX-Pembrolizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Capecitabine'</newAxiom>
<newAxiom>'CAPOX-Pembrolizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pembrolizumab'</newAxiom>
<newAxiom>'CAPOX-Pembrolizumab Regimen' SubClassOf 'Regimen Used to Treat Esophageal Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192153</classIRI>
<classLabel>Capecitabine/Cisplatin/Pembrolizumab Regimen</classLabel>
<newAxiom>'Capecitabine/Cisplatin/Pembrolizumab Regimen' SubClassOf 'Regimen Used to Treat Esophageal Carcinoma'</newAxiom>
<newAxiom>'Capecitabine/Cisplatin/Pembrolizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cisplatin'</newAxiom>
<newAxiom>'Capecitabine/Cisplatin/Pembrolizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Capecitabine'</newAxiom>
<newAxiom>'Capecitabine/Cisplatin/Pembrolizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pembrolizumab'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192150</classIRI>
<classLabel>Establish Processes and Procedures to Provide</classLabel>
<newAxiom>'Establish Processes and Procedures to Provide' SubClassOf 'Risk Evaluation and Mitigation Strategies Requirement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192151</classIRI>
<classLabel>Notify of Safe Use Conditions</classLabel>
<newAxiom>'Notify of Safe Use Conditions' SubClassOf 'Risk Evaluation and Mitigation Strategies Requirement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192149</classIRI>
<classLabel>Calaspargase Pegol Regimen</classLabel>
<newAxiom>'Calaspargase Pegol Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'Calaspargase Pegol Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Calaspargase Pegol'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192147</classIRI>
<classLabel>Report Treatment Discontinuation or Transfer of Care</classLabel>
<newAxiom>'Report Treatment Discontinuation or Transfer of Care' SubClassOf 'Risk Evaluation and Mitigation Strategies Requirement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192148</classIRI>
<classLabel>Establish Processes and Procedures to Notify</classLabel>
<newAxiom>'Establish Processes and Procedures to Notify' SubClassOf 'Risk Evaluation and Mitigation Strategies Requirement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192145</classIRI>
<classLabel>Cabazitaxel/Carboplatin/Prednisone Regimen</classLabel>
<newAxiom>'Cabazitaxel/Carboplatin/Prednisone Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cabazitaxel'</newAxiom>
<newAxiom>'Cabazitaxel/Carboplatin/Prednisone Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Carboplatin'</newAxiom>
<newAxiom>'Cabazitaxel/Carboplatin/Prednisone Regimen' SubClassOf 'Regimen_Has_Accepted_Use_For_Disease' some 'Metastatic Prostate Carcinoma'</newAxiom>
<newAxiom>'Cabazitaxel/Carboplatin/Prednisone Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Prednisone'</newAxiom>
<newAxiom>'Cabazitaxel/Carboplatin/Prednisone Regimen' SubClassOf 'Regimen Used to Treat Prostate Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192146</classIRI>
<classLabel>Cabozantinib/Nivolumab Regimen</classLabel>
<newAxiom>'Cabozantinib/Nivolumab Regimen' SubClassOf 'Regimen Used to Treat Malignant Renal Neoplasm'</newAxiom>
<newAxiom>'Cabozantinib/Nivolumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cabozantinib S-malate'</newAxiom>
<newAxiom>'Cabozantinib/Nivolumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Nivolumab'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192143</classIRI>
<classLabel>Autologous Anti-ROR1 CAR-T Cells BMS-986403</classLabel>
<newAxiom>'Autologous Anti-ROR1 CAR-T Cells BMS-986403' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Autologous Anti-ROR1 CAR-T Cells BMS-986403' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Autologous Anti-ROR1 CAR-T Cells BMS-986403' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192144</classIRI>
<classLabel>Paratesticular Mesothelial Neoplasm</classLabel>
<newAxiom>'Paratesticular Mesothelial Neoplasm' EquivalentTo 'Paratesticular Neoplasm' and 'Mesothelial Neoplasm' and ('Disease_Has_Primary_Anatomic_Site' some 'Paratesticular Region')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192141</classIRI>
<classLabel>Paratesticular Endometrioid Tumor</classLabel>
<newAxiom>'Paratesticular Endometrioid Tumor' EquivalentTo 'Paratesticular Epithelial Neoplasm' and 'Endometrioid Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192142</classIRI>
<classLabel>Paratesticular Clear Cell Adenocarcinoma</classLabel>
<newAxiom>'Paratesticular Clear Cell Adenocarcinoma' EquivalentTo 'Paratesticular Carcinoma' and 'Clear Cell Adenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192140</classIRI>
<classLabel>Benign Paratesticular Neoplasm</classLabel>
<newAxiom>'Benign Paratesticular Neoplasm' EquivalentTo 'Paratesticular Neoplasm' and 'Benign Male Reproductive System Neoplasm' and ('Disease_Has_Primary_Anatomic_Site' some 'Paratesticular Region')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192138</classIRI>
<classLabel>Pegylated Orthogonal IL-2 STK-009</classLabel>
<newAxiom>'Pegylated Orthogonal IL-2 STK-009' SubClassOf 'Recombinant Interleukin-2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192139</classIRI>
<classLabel>Malignant Paratesticular Neoplasm</classLabel>
<newAxiom>'Malignant Paratesticular Neoplasm' EquivalentTo 'Paratesticular Neoplasm' and 'Malignant Male Reproductive System Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192136</classIRI>
<classLabel>Very Bad Experience</classLabel>
<newAxiom>'Very Bad Experience' SubClassOf 'Bad Experience'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192137</classIRI>
<classLabel>Autologous Orthogonal IL-2Rbeta-expressing Anti-CD19 CAR T-cells SYNCAR-001</classLabel>
<newAxiom>'Autologous Orthogonal IL-2Rbeta-expressing Anti-CD19 CAR T-cells SYNCAR-001' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
<newAxiom>'Autologous Orthogonal IL-2Rbeta-expressing Anti-CD19 CAR T-cells SYNCAR-001' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Autologous Orthogonal IL-2Rbeta-expressing Anti-CD19 CAR T-cells SYNCAR-001' SubClassOf 'Anti-CD19-targeting CAR-T Cells'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192134</classIRI>
<classLabel>A Little Bad</classLabel>
<newAxiom>'A Little Bad' SubClassOf 'A Little Answer'</newAxiom>
<newAxiom>'A Little Bad' SubClassOf 'Bad Experience'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192135</classIRI>
<classLabel>Bad Experience</classLabel>
<newAxiom>'Bad Experience' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192132</classIRI>
<classLabel>PD-L1 Expression Less than 50 Percent</classLabel>
<newAxiom>'PD-L1 Expression Less than 50 Percent' SubClassOf 'Immunohistochemical Status of PD-L1'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192133</classIRI>
<classLabel>Did Not Have</classLabel>
<newAxiom>'Did Not Have' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192130</classIRI>
<classLabel>Seminal Versicle Carcinoma</classLabel>
<newAxiom>'Seminal Versicle Carcinoma' EquivalentTo 'Malignant Seminal Vesicle Neoplasm' and 'Male Reproductive System Carcinoma' and ('Disease_Has_Primary_Anatomic_Site' some 'Seminal Vesicle')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192131</classIRI>
<classLabel>Refractory Invasive Pulmonary Aspergillosis</classLabel>
<newAxiom>'Refractory Invasive Pulmonary Aspergillosis' SubClassOf 'Invasive Pulmonary Aspergillosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192129</classIRI>
<classLabel>Paratesticular Carcinoma</classLabel>
<newAxiom>'Paratesticular Carcinoma' EquivalentTo 'Male Reproductive System Carcinoma' and 'Paratesticular Epithelial Neoplasm' and 'Malignant Paratesticular Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192127</classIRI>
<classLabel>Borderline Paratesticular Mucinous Tumor</classLabel>
<newAxiom>'Borderline Paratesticular Mucinous Tumor' EquivalentTo 'Paratesticular Epithelial Neoplasm' and 'Neoplasm of Uncertain Malignant Potential' and ('Disease_Has_Abnormal_Cell' some 'Neoplastic Epithelial Cell with Intracytoplasmic Mucin') and ('Disease_Has_Finding' some 'Absence of Stromal Invasion') and ('Disease_Has_Finding' some 'Atypia')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192128</classIRI>
<classLabel>Paratesticular Mucinous Cystadenocarcinoma</classLabel>
<newAxiom>'Paratesticular Mucinous Cystadenocarcinoma' EquivalentTo 'Paratesticular Carcinoma' and 'Mucinous Cystadenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192125</classIRI>
<classLabel>Paratesticular Serous Cystadenocarcinoma</classLabel>
<newAxiom>'Paratesticular Serous Cystadenocarcinoma' EquivalentTo 'Paratesticular Carcinoma' and 'Serous Cystadenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192126</classIRI>
<classLabel>Paratesticular Mucinous Cystadenoma</classLabel>
<newAxiom>'Paratesticular Mucinous Cystadenoma' EquivalentTo 'Paratesticular Epithelial Neoplasm' and 'Benign Paratesticular Neoplasm' and 'Mucinous Cystadenoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192123</classIRI>
<classLabel>Paratesticular Serous Cystadenoma</classLabel>
<newAxiom>'Paratesticular Serous Cystadenoma' EquivalentTo 'Paratesticular Epithelial Neoplasm' and 'Benign Paratesticular Neoplasm' and 'Serous Cystadenoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192124</classIRI>
<classLabel>Borderline Paratesticular Serous Tumor</classLabel>
<newAxiom>'Borderline Paratesticular Serous Tumor' EquivalentTo 'Paratesticular Epithelial Neoplasm' and 'Neoplasm of Uncertain Malignant Potential' and ('Disease_Has_Abnormal_Cell' some 'Neoplastic Serous Epithelial Cell') and ('Disease_Has_Abnormal_Cell' some 'Neoplastic Columnar Epithelial Cell') and ('Disease_Has_Finding' some 'Absence of Stromal Invasion') and ('Disease_Has_Finding' some 'Atypia')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192121</classIRI>
<classLabel>Paratesticular Well Differentiated Papillary Mesothelial Tumor</classLabel>
<newAxiom>'Paratesticular Well Differentiated Papillary Mesothelial Tumor' EquivalentTo 'Paratesticular Mesothelial Neoplasm' and 'Well Differentiated Papillary Mesothelial Tumor' and ('Disease_Has_Primary_Anatomic_Site' some 'Tunica Vaginalis')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192122</classIRI>
<classLabel>Paratesticular Epithelial Neoplasm</classLabel>
<newAxiom>'Paratesticular Epithelial Neoplasm' EquivalentTo 'Paratesticular Neoplasm' and 'Epithelial Neoplasm' and ('Disease_Has_Primary_Anatomic_Site' some 'Paratesticular Region')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192120</classIRI>
<classLabel>Epididymal Carcinoma</classLabel>
<newAxiom>'Epididymal Carcinoma' EquivalentTo 'Paratesticular Carcinoma' and 'Malignant Epididymal Neoplasm' and ('Disease_Has_Primary_Anatomic_Site' some 'Epididymis')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192118</classIRI>
<classLabel>Severity of Mouth or Throat Pain</classLabel>
<newAxiom>'Severity of Mouth or Throat Pain' SubClassOf 'Severity Question'</newAxiom>
<newAxiom>'Severity of Mouth or Throat Pain' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192119</classIRI>
<classLabel>Epididymal Squamous Cell Carcinoma</classLabel>
<newAxiom>'Epididymal Squamous Cell Carcinoma' EquivalentTo 'Paratesticular Squamous Cell Carcinoma' and 'Epididymal Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192116</classIRI>
<classLabel>Gonadal Myoid Stromal Tumor</classLabel>
<newAxiom>'Gonadal Myoid Stromal Tumor' EquivalentTo 'Benign Testicular Neoplasm' and ('Disease_Has_Abnormal_Cell' some 'Neoplastic Spindle Cell') and ('Disease_Has_Finding' some 'Well-Circumscribed Lesion') and ('Disease_Has_Finding' some 'Myofibroblastic Differentiation')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192117</classIRI>
<classLabel>Autologous Anti-HLA-G CAR-T Cells IVS-3001</classLabel>
<newAxiom>'Autologous Anti-HLA-G CAR-T Cells IVS-3001' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Autologous Anti-HLA-G CAR-T Cells IVS-3001' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Autologous Anti-HLA-G CAR-T Cells IVS-3001' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192114</classIRI>
<classLabel>With a Lot of Trouble</classLabel>
<newAxiom>'With a Lot of Trouble' SubClassOf 'Ability Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192115</classIRI>
<classLabel>Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal-Type</classLabel>
<newAxiom>'Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal-Type' EquivalentTo 'Testicular Mixed Yolk Sac Tumor and Teratoma' and ('Disease_Has_Finding' some 'Prepubertal-Type Lesion') and ('Disease_Excludes_Cytogenetic_Abnormality' some 'Gain of Chromosome 12p')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192112</classIRI>
<classLabel>With a Little Trouble</classLabel>
<newAxiom>'With a Little Trouble' SubClassOf 'Ability Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192113</classIRI>
<classLabel>With Some Trouble</classLabel>
<newAxiom>'With Some Trouble' SubClassOf 'Ability Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192110</classIRI>
<classLabel>Anti-CCR8 Monoclonal Antibody BAY3375968</classLabel>
<newAxiom>'Anti-CCR8 Monoclonal Antibody BAY3375968' SubClassOf 'Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-CCR8 Monoclonal Antibody BAY3375968' SubClassOf 'Immune Checkpoint Modulator'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192111</classIRI>
<classLabel>With No Trouble</classLabel>
<newAxiom>'With No Trouble' SubClassOf 'Ability Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192109</classIRI>
<classLabel>Medical Product Dispensation- or Prescription-Related Activity</classLabel>
<newAxiom>'Medical Product Dispensation- or Prescription-Related Activity' SubClassOf 'Medical Product or Procedure Usage and Evaluation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192107</classIRI>
<classLabel>Testicular Teratoma, Prepubertal-Type</classLabel>
<newAxiom>'Testicular Teratoma, Prepubertal-Type' EquivalentTo 'Testicular Teratoma' and ('Disease_Has_Finding' some 'Prepubertal-Type Lesion') and ('Disease_Has_Finding' some 'Indolent Clinical Course') and ('Disease_Excludes_Cytogenetic_Abnormality' some 'Gain of Chromosome 12p') and ('Disease_Excludes_Finding' some 'Cytologic Atypia')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192108</classIRI>
<classLabel>Risk Assessment for Hereditary Cancer</classLabel>
<newAxiom>'Risk Assessment for Hereditary Cancer' SubClassOf 'Risk Assessment'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192105</classIRI>
<classLabel>Cystic Trophoblastic Tumor</classLabel>
<newAxiom>'Cystic Trophoblastic Tumor' EquivalentTo 'Trophoblastic Tumor' and 'Cystic Neoplasm' and ('Disease_Has_Abnormal_Cell' some 'Neoplastic Intermediate Type Trophoblastic Cell') and ('Disease_May_Have_Finding' some 'Mixture of Germ Cell Neoplastic Components Present')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192106</classIRI>
<classLabel>Testicular Cystic Trophoblastic Tumor</classLabel>
<newAxiom>'Testicular Cystic Trophoblastic Tumor' EquivalentTo 'Cystic Trophoblastic Tumor' and 'Testicular Trophoblastic Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192103</classIRI>
<classLabel>Selective Estrogen Receptor Degrader SCO-120</classLabel>
<newAxiom>'Selective Estrogen Receptor Degrader SCO-120' SubClassOf 'Selective Estrogen Receptor Down Regulator'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192104</classIRI>
<classLabel>4-Dimensional Magnetic Resonance Imaging</classLabel>
<newAxiom>'4-Dimensional Magnetic Resonance Imaging' SubClassOf 'Magnetic Resonance Imaging'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192101</classIRI>
<classLabel>Weight-based Dose</classLabel>
<newAxiom>'Weight-based Dose' SubClassOf 'Dose'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192102</classIRI>
<classLabel>Fixed Dose</classLabel>
<newAxiom>'Fixed Dose' SubClassOf 'Dose'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192100</classIRI>
<classLabel>Testicular Yolk Sac Tumor, Prepubertal-Type</classLabel>
<newAxiom>'Testicular Yolk Sac Tumor, Prepubertal-Type' EquivalentTo 'Childhood Testicular Yolk Sac Tumor' and ('Disease_Has_Finding' some 'Prepubertal-Type Lesion') and ('Disease_Excludes_Cytogenetic_Abnormality' some 'Gain of Chromosome 12p')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192198</classIRI>
<classLabel>Mercaptopurine/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen</classLabel>
<newAxiom>'Mercaptopurine/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Mercaptopurine/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Prednisone'</newAxiom>
<newAxiom>'Mercaptopurine/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Mercaptopurine'</newAxiom>
<newAxiom>'Mercaptopurine/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'Mercaptopurine/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Methotrexate'</newAxiom>
<newAxiom>'Mercaptopurine/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegaspargase'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192199</classIRI>
<classLabel>Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine Regimen</classLabel>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Thioguanine'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cytarabine Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Doxorubicin Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Dexamethasone'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192196</classIRI>
<classLabel>Cyclophosphamide/Daunorubicin/Pegaspargase/Prednisone/Vincristine Regimen</classLabel>
<newAxiom>'Cyclophosphamide/Daunorubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Prednisone'</newAxiom>
<newAxiom>'Cyclophosphamide/Daunorubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Daunorubicin Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Daunorubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'Cyclophosphamide/Daunorubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegaspargase'</newAxiom>
<newAxiom>'Cyclophosphamide/Daunorubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Cyclophosphamide/Daunorubicin/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192197</classIRI>
<classLabel>Cyclophosphamide/Daunorubicin/Dexamethasone/Pegaspargase/Vincristine Regimen</classLabel>
<newAxiom>'Cyclophosphamide/Daunorubicin/Dexamethasone/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Daunorubicin Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Daunorubicin/Dexamethasone/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
<newAxiom>'Cyclophosphamide/Daunorubicin/Dexamethasone/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegaspargase'</newAxiom>
<newAxiom>'Cyclophosphamide/Daunorubicin/Dexamethasone/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Cyclophosphamide/Daunorubicin/Dexamethasone/Pegaspargase/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'Cyclophosphamide/Daunorubicin/Dexamethasone/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Dexamethasone'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192194</classIRI>
<classLabel>Cytarabine/Dexamethasone/Etoposide/Vincristine Regimen</classLabel>
<newAxiom>'Cytarabine/Dexamethasone/Etoposide/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'Cytarabine/Dexamethasone/Etoposide/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cytarabine Hydrochloride'</newAxiom>
<newAxiom>'Cytarabine/Dexamethasone/Etoposide/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Etoposide'</newAxiom>
<newAxiom>'Cytarabine/Dexamethasone/Etoposide/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Cytarabine/Dexamethasone/Etoposide/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Dexamethasone'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192195</classIRI>
<classLabel>Long QT Syndrome 11</classLabel>
<newAxiom>'Long QT Syndrome 11' SubClassOf 'Disease_Mapped_To_Gene' some 'AKAP9 Gene'</newAxiom>
<newAxiom>'Long QT Syndrome 11' SubClassOf 'Long QT Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192192</classIRI>
<classLabel>Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine Regimen</classLabel>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegaspargase'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Dexamethasone'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cytarabine Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Methotrexate'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Etoposide'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Mercaptopurine'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192193</classIRI>
<classLabel>Dexamethasone/Vincristine Regimen</classLabel>
<newAxiom>'Dexamethasone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Dexamethasone'</newAxiom>
<newAxiom>'Dexamethasone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Dexamethasone/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192190</classIRI>
<classLabel>Platelet Refractoriness</classLabel>
<newAxiom>'Platelet Refractoriness' SubClassOf 'Abnormal Hematology Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192191</classIRI>
<classLabel>CD40L-augmented Autologous Tumor Infiltrating Lymphocytes</classLabel>
<newAxiom>'CD40L-augmented Autologous Tumor Infiltrating Lymphocytes' SubClassOf 'Therapeutic Tumor Infiltrating Lymphocytes'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192189</classIRI>
<classLabel>Decreased Levels of HLA Class I Panel Reactive Antibody</classLabel>
<newAxiom>'Decreased Levels of HLA Class I Panel Reactive Antibody' SubClassOf 'Immunophenotypic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192187</classIRI>
<classLabel>Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen</classLabel>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Daunorubicin Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cytarabine Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Prednisone'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Methotrexate'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Idarubicin Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegaspargase'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192188</classIRI>
<classLabel>HLA Class I Panel Reactive Antibody</classLabel>
<newAxiom>'HLA Class I Panel Reactive Antibody' SubClassOf 'Biomarker'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192185</classIRI>
<classLabel>4-Hydroxy-1-(3-Pyridyl)-1-Butanone</classLabel>
<newAxiom>'4-Hydroxy-1-(3-Pyridyl)-1-Butanone' SubClassOf 'Aromatic Hydrocarbon'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192186</classIRI>
<classLabel>Anti-CD27 Monoclonal Antibody</classLabel>
<newAxiom>'Anti-CD27 Monoclonal Antibody' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-CD27 Monoclonal Antibody' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192183</classIRI>
<classLabel>One Hundred Eight</classLabel>
<newAxiom>'One Hundred Eight' SubClassOf 'Natural Number'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192184</classIRI>
<classLabel>One Hundred Twenty</classLabel>
<newAxiom>'One Hundred Twenty' SubClassOf 'Natural Number'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192182</classIRI>
<classLabel>Ninety Six</classLabel>
<newAxiom>'Ninety Six' SubClassOf 'Natural Number'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192057</classIRI>
<classLabel>mFolfirinox-Bevacizumab Regimen</classLabel>
<newAxiom>'mFolfirinox-Bevacizumab Regimen' SubClassOf 'Regimen Used to Treat Colorectal Carcinoma'</newAxiom>
<newAxiom>'mFolfirinox-Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Bevacizumab'</newAxiom>
<newAxiom>'mFolfirinox-Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Irinotecan Hydrochloride'</newAxiom>
<newAxiom>'mFolfirinox-Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Leucovorin Calcium'</newAxiom>
<newAxiom>'mFolfirinox-Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Fluorouracil'</newAxiom>
<newAxiom>'mFolfirinox-Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Oxaliplatin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192058</classIRI>
<classLabel>Spastic Paraplegia 10</classLabel>
<newAxiom>'Spastic Paraplegia 10' SubClassOf 'Hereditary Spastic Paraplegia'</newAxiom>
<newAxiom>'Spastic Paraplegia 10' SubClassOf 'Disease_Mapped_To_Gene' some 'KIF5A Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192055</classIRI>
<classLabel>Age at Genetic Analysis</classLabel>
<newAxiom>'Age at Genetic Analysis' SubClassOf 'Age'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192056</classIRI>
<classLabel>Folfirinox-Bevacizumab Regimen</classLabel>
<newAxiom>'Folfirinox-Bevacizumab Regimen' SubClassOf 'Regimen Used to Treat Colorectal Carcinoma'</newAxiom>
<newAxiom>'Folfirinox-Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Fluorouracil'</newAxiom>
<newAxiom>'Folfirinox-Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Irinotecan Hydrochloride'</newAxiom>
<newAxiom>'Folfirinox-Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Oxaliplatin'</newAxiom>
<newAxiom>'Folfirinox-Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Bevacizumab'</newAxiom>
<newAxiom>'Folfirinox-Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Leucovorin Calcium'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192053</classIRI>
<classLabel>MOpAD/Rituximab Regimen</classLabel>
<newAxiom>'MOpAD/Rituximab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Dexamethasone'</newAxiom>
<newAxiom>'MOpAD/Rituximab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegaspargase'</newAxiom>
<newAxiom>'MOpAD/Rituximab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine'</newAxiom>
<newAxiom>'MOpAD/Rituximab Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'MOpAD/Rituximab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Rituximab'</newAxiom>
<newAxiom>'MOpAD/Rituximab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Methotrexate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192054</classIRI>
<classLabel>Facial Hedonic Scale</classLabel>
<newAxiom>'Facial Hedonic Scale' SubClassOf 'Visual Analog Scale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192051</classIRI>
<classLabel>PROMIS Pediatric and Parent Proxy Mental Health Domain</classLabel>
<newAxiom>'PROMIS Pediatric and Parent Proxy Mental Health Domain' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192052</classIRI>
<classLabel>MOpAD Regimen</classLabel>
<newAxiom>'MOpAD Regimen' SubClassOf 'Regimen Used to Treat Acute Lymphoblastic Leukemia'</newAxiom>
<newAxiom>'MOpAD Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine'</newAxiom>
<newAxiom>'MOpAD Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Dexamethasone'</newAxiom>
<newAxiom>'MOpAD Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Methotrexate'</newAxiom>
<newAxiom>'MOpAD Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pegaspargase'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192050</classIRI>
<classLabel>Physical Function - Mobility Subordinate Domain</classLabel>
<newAxiom>'Physical Function - Mobility Subordinate Domain' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192048</classIRI>
<classLabel>Emotional Distress - Depressive Symptoms Subordinate Domain</classLabel>
<newAxiom>'Emotional Distress - Depressive Symptoms Subordinate Domain' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192049</classIRI>
<classLabel>Sleep-Related Disturbance Subordinate Domain</classLabel>
<newAxiom>'Sleep-Related Disturbance Subordinate Domain' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192046</classIRI>
<classLabel>How Much Trouble</classLabel>
<newAxiom>'How Much Trouble' SubClassOf 'Have Trouble or Difficulty Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192047</classIRI>
<classLabel>Emotional Distress - Anxiety Subordinate Domain</classLabel>
<newAxiom>'Emotional Distress - Anxiety Subordinate Domain' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192044</classIRI>
<classLabel>Could Get Up from Floor</classLabel>
<newAxiom>'Could Get Up from Floor' SubClassOf 'Play or Do Physical Activity Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192045</classIRI>
<classLabel>Physically Able to Do Activities I Enjoy Most</classLabel>
<newAxiom>'Physically Able to Do Activities I Enjoy Most' SubClassOf 'Play or Do Physical Activity Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192042</classIRI>
<classLabel>Could Do Sports and Exercise Other Kids Same Age Could Do</classLabel>
<newAxiom>'Could Do Sports and Exercise Other Kids Same Age Could Do' SubClassOf 'Play or Do Physical Activity Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192043</classIRI>
<classLabel>Could Walk Up Stairs Unassisted</classLabel>
<newAxiom>'Could Walk Up Stairs Unassisted' SubClassOf 'Climbing Steps or Stairs Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192040</classIRI>
<classLabel>Problem with My Sleep</classLabel>
<newAxiom>'Problem with My Sleep' SubClassOf 'Sleep Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192041</classIRI>
<classLabel>CVAD/Rituximab Regimen</classLabel>
<newAxiom>'CVAD/Rituximab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
<newAxiom>'CVAD/Rituximab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'CVAD/Rituximab Regimen' SubClassOf 'Regimen Used to Treat Castleman disease'</newAxiom>
<newAxiom>'CVAD/Rituximab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Rituximab'</newAxiom>
<newAxiom>'CVAD/Rituximab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Dexamethasone'</newAxiom>
<newAxiom>'CVAD/Rituximab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Doxorubicin Hydrochloride'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192039</classIRI>
<classLabel>Slept Through the Night</classLabel>
<newAxiom>'Slept Through the Night' SubClassOf 'Sleep Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192037</classIRI>
<classLabel>Felt Everything in My Life Went Wrong</classLabel>
<newAxiom>'Felt Everything in My Life Went Wrong' SubClassOf 'Feelings Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192038</classIRI>
<classLabel>Hard For me to Have Fun</classLabel>
<newAxiom>'Hard For me to Have Fun' SubClassOf 'Have Trouble or Difficulty Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192035</classIRI>
<classLabel>Worried When at Home</classLabel>
<newAxiom>'Worried When at Home' SubClassOf 'Worry Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192036</classIRI>
<classLabel>Cyclophosphamide/Epirubicin/Vincristine Regimen</classLabel>
<newAxiom>'Cyclophosphamide/Epirubicin/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Epirubicin Hydrochloride'</newAxiom>
<newAxiom>'Cyclophosphamide/Epirubicin/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Cyclophosphamide/Epirubicin/Vincristine Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
<newAxiom>'Cyclophosphamide/Epirubicin/Vincristine Regimen' SubClassOf 'Regimen Used to Treat Merkel Cell Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192030</classIRI>
<classLabel>Dose-adjusted EPOCH Regimen</classLabel>
<newAxiom>'Dose-adjusted EPOCH Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Etoposide'</newAxiom>
<newAxiom>'Dose-adjusted EPOCH Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cyclophosphamide'</newAxiom>
<newAxiom>'Dose-adjusted EPOCH Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Prednisone'</newAxiom>
<newAxiom>'Dose-adjusted EPOCH Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Vincristine Sulfate'</newAxiom>
<newAxiom>'Dose-adjusted EPOCH Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Doxorubicin Hydrochloride'</newAxiom>
<newAxiom>'Dose-adjusted EPOCH Regimen' SubClassOf 'Regimen Used to Treat Non-Hodgkin Lymphoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192028</classIRI>
<classLabel>mFOLFOX6-Bevacizumab  Regimen</classLabel>
<newAxiom>'mFOLFOX6-Bevacizumab  Regimen' SubClassOf 'Regimen Used to Treat Colorectal Carcinoma'</newAxiom>
<newAxiom>'mFOLFOX6-Bevacizumab  Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Oxaliplatin'</newAxiom>
<newAxiom>'mFOLFOX6-Bevacizumab  Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Bevacizumab'</newAxiom>
<newAxiom>'mFOLFOX6-Bevacizumab  Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Fluorouracil'</newAxiom>
<newAxiom>'mFOLFOX6-Bevacizumab  Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Leucovorin Calcium'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192029</classIRI>
<classLabel>Neuro QOL Pediatric Mental Health Domain</classLabel>
<newAxiom>'Neuro QOL Pediatric Mental Health Domain' SubClassOf 'Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192026</classIRI>
<classLabel>Bevacizumab/Cisplatin/Pemetrexed Followed by Bevacizumab Regimen</classLabel>
<newAxiom>'Bevacizumab/Cisplatin/Pemetrexed Followed by Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Cisplatin'</newAxiom>
<newAxiom>'Bevacizumab/Cisplatin/Pemetrexed Followed by Bevacizumab Regimen' SubClassOf 'Regimen Used to Treat Malignant Mesothelioma'</newAxiom>
<newAxiom>'Bevacizumab/Cisplatin/Pemetrexed Followed by Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pemetrexed Disodium'</newAxiom>
<newAxiom>'Bevacizumab/Cisplatin/Pemetrexed Followed by Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Bevacizumab'</newAxiom>
<newAxiom>'Bevacizumab/Cisplatin/Pemetrexed Followed by Bevacizumab Regimen' SubClassOf 'Regimen_Has_Accepted_Use_For_Disease' some 'Malignant Mesothelioma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192027</classIRI>
<classLabel>Bevacizumab/Carboplatin/Pemetrexed Followed by Bevacizumab Regimen</classLabel>
<newAxiom>'Bevacizumab/Carboplatin/Pemetrexed Followed by Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Bevacizumab'</newAxiom>
<newAxiom>'Bevacizumab/Carboplatin/Pemetrexed Followed by Bevacizumab Regimen' SubClassOf 'Regimen Used to Treat Malignant Mesothelioma'</newAxiom>
<newAxiom>'Bevacizumab/Carboplatin/Pemetrexed Followed by Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Pemetrexed Disodium'</newAxiom>
<newAxiom>'Bevacizumab/Carboplatin/Pemetrexed Followed by Bevacizumab Regimen' SubClassOf 'Regimen_Has_Accepted_Use_For_Disease' some 'Malignant Mesothelioma'</newAxiom>
<newAxiom>'Bevacizumab/Carboplatin/Pemetrexed Followed by Bevacizumab Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Carboplatin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192024</classIRI>
<classLabel>IL-2/Anti-IL-2 Antibody Conjugate SLC-3010</classLabel>
<newAxiom>'IL-2/Anti-IL-2 Antibody Conjugate SLC-3010' SubClassOf 'Recombinant Interleukin-2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192025</classIRI>
<classLabel>Bcl-2 Family Protein Inhibitor</classLabel>
<newAxiom>'Bcl-2 Family Protein Inhibitor' SubClassOf 'Apoptotic Pathway-targeting Antineoplastic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192022</classIRI>
<classLabel>A Disintegrin and Metalloproteinase with Thrombospondin Motifs 2</classLabel>
<newAxiom>'A Disintegrin and Metalloproteinase with Thrombospondin Motifs 2' EquivalentTo 'Metallopeptidase' and ('Gene_Product_Has_Chemical_Classification' some 'Peptidase Family M12B') and ('Gene_Product_Has_Associated_Anatomy' some 'Extracellular Matrix') and ('Gene_Product_Has_Associated_Anatomy' some 'Extracellular Space') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Disintegrin Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Protein Cleavage') and ('Gene_Product_Encoded_By_Gene' some 'ADAMTS2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192023</classIRI>
<classLabel>Recurrent Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Recurrent Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Recurrent Neuroendocrine Carcinoma' and 'Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192020</classIRI>
<classLabel>ADAMTS2 Gene</classLabel>
<newAxiom>'ADAMTS2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Protein Cleavage'</newAxiom>
<newAxiom>'ADAMTS2 Gene' SubClassOf 'Metallopeptidase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192021</classIRI>
<classLabel>ADAMTS2 wt Allele</classLabel>
<newAxiom>'ADAMTS2 wt Allele' SubClassOf 'ADAMTS2 Gene'</newAxiom>
<newAxiom>'ADAMTS2 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '5q35.3'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192019</classIRI>
<classLabel>Soluble Corn Fiber Prebiotic Supplement</classLabel>
<newAxiom>'Soluble Corn Fiber Prebiotic Supplement' SubClassOf 'Dietary Supplement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192017</classIRI>
<classLabel>Fluorine F 18 Boronophenylalanine</classLabel>
<newAxiom>'Fluorine F 18 Boronophenylalanine' SubClassOf 'Radioconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192018</classIRI>
<classLabel>Unresectable Lung Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Unresectable Lung Neuroendocrine Carcinoma' EquivalentTo 'Unresectable Lung Carcinoma' and 'Unresectable Lung Neuroendocrine Neoplasm' and 'Unresectable Neuroendocrine Carcinoma' and 'Lung Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192015</classIRI>
<classLabel>Have Trouble Paying Attention to Teacher</classLabel>
<newAxiom>'Have Trouble Paying Attention to Teacher' SubClassOf 'Have Trouble or Difficulty Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192016</classIRI>
<classLabel>Have to Work Hard to Pay Attention or Will Make a Mistake</classLabel>
<newAxiom>'Have to Work Hard to Pay Attention or Will Make a Mistake' SubClassOf 'Ability Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192013</classIRI>
<classLabel>Hard to Concentrate in School</classLabel>
<newAxiom>'Hard to Concentrate in School' SubClassOf 'Have Trouble or Difficulty Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192014</classIRI>
<classLabel>Unresectable Small Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Unresectable Small Cell Neuroendocrine Carcinoma' EquivalentTo 'Unresectable Neuroendocrine Carcinoma' and 'Small Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192011</classIRI>
<classLabel>Anti-HER2/4-1BB Bispecific Antibody YH32367</classLabel>
<newAxiom>'Anti-HER2/4-1BB Bispecific Antibody YH32367' SubClassOf 'Bispecific Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-HER2/4-1BB Bispecific Antibody YH32367' SubClassOf 'Anti-CD137 Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-HER2/4-1BB Bispecific Antibody YH32367' SubClassOf 'Anti-HER2 Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192012</classIRI>
<classLabel>Have Trouble Remembering to do Things</classLabel>
<newAxiom>'Have Trouble Remembering to do Things' SubClassOf 'Memory Question'</newAxiom>
<newAxiom>'Have Trouble Remembering to do Things' SubClassOf 'Have Trouble or Difficulty Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192010</classIRI>
<classLabel>Forget Things Easily</classLabel>
<newAxiom>'Forget Things Easily' SubClassOf 'Forget Things'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192008</classIRI>
<classLabel>Rho GDP-Dissociation Inhibitor 1</classLabel>
<newAxiom>'Rho GDP-Dissociation Inhibitor 1' EquivalentTo 'Signaling Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'Neurotrophin Signaling Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Vasopressin-Regulated Water Reabsorption Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Nerve Growth Factor Receptor Signaling Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'PDGFR-beta Signaling Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Immunoglobulin Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cell Movement Process') and ('Gene_Product_Encoded_By_Gene' some 'ARHGDIA Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192009</classIRI>
<classLabel>React Slower than Most People My Age</classLabel>
<newAxiom>'React Slower than Most People My Age' SubClassOf 'Ability Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192006</classIRI>
<classLabel>Forget Schoolwork that Needs to be Done</classLabel>
<newAxiom>'Forget Schoolwork that Needs to be Done' SubClassOf 'Memory Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192007</classIRI>
<classLabel>Sometimes Forget What was Going to Say</classLabel>
<newAxiom>'Sometimes Forget What was Going to Say' SubClassOf 'Memory Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192004</classIRI>
<classLabel>Neuro QOL Item Bank v2.0 - Pediatric Cognitive Function</classLabel>
<newAxiom>'Neuro QOL Item Bank v2.0 - Pediatric Cognitive Function' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192005</classIRI>
<classLabel>EGFR Mutant-selective Inhibitor QLH11811</classLabel>
<newAxiom>'EGFR Mutant-selective Inhibitor QLH11811' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'EGFR Mutant-selective Inhibitor QLH11811' SubClassOf 'Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192002</classIRI>
<classLabel>ARHGDIA Gene</classLabel>
<newAxiom>'ARHGDIA Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cell Movement'</newAxiom>
<newAxiom>'ARHGDIA Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192003</classIRI>
<classLabel>ARHGDIA wt Allele</classLabel>
<newAxiom>'ARHGDIA wt Allele' EquivalentTo 'ARHGDIA Gene' and ('Gene_Is_Element_In_Pathway' some 'Neurotrophin Signaling Pathway') and ('Gene_Is_Element_In_Pathway' some 'Vasopressin-Regulated Water Reabsorption Pathway') and ('Gene_Is_Element_In_Pathway' some 'Nerve Growth Factor Receptor Signaling Pathway') and ('Gene_Is_Element_In_Pathway' some 'PDGFR-beta Signaling Pathway') and ('Gene_In_Chromosomal_Location' some '17q25.3')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192000</classIRI>
<classLabel>Rho GTPase-Activating Protein 24</classLabel>
<newAxiom>'Rho GTPase-Activating Protein 24' EquivalentTo 'GTPase-Activating Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Has_Associated_Anatomy' some 'Zonula Adherens') and ('Gene_Product_Has_Associated_Anatomy' some 'Lamellipodia') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Coiled-Coil Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'PH Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Angiogenic Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cytoskeletal Modeling') and ('Gene_Product_Encoded_By_Gene' some 'ARHGAP24 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192001</classIRI>
<classLabel>Allogeneic Polymer-encapsulated IL-2-secreting Retinal Pigmented Epithelial Cells AVB-001</classLabel>
<newAxiom>'Allogeneic Polymer-encapsulated IL-2-secreting Retinal Pigmented Epithelial Cells AVB-001' SubClassOf 'Adoptive Cell Therapy Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192099</classIRI>
<classLabel>Testicular Yolk Sac Tumor, Postpubertal-Type</classLabel>
<newAxiom>'Testicular Yolk Sac Tumor, Postpubertal-Type' EquivalentTo 'Testicular Yolk Sac Tumor' and ('Disease_May_Have_Associated_Disease' some 'Testicular Mixed Germ Cell Tumor') and ('Disease_Has_Associated_Disease' some 'Testicular Germ Cell Neoplasia In Situ') and ('Disease_Excludes_Finding' some 'Prepubertal-Type Lesion')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192097</classIRI>
<classLabel>Amivantamab and Recombinant Human Hyaluronidase</classLabel>
<newAxiom>'Amivantamab and Recombinant Human Hyaluronidase' SubClassOf 'Anti-c-Met Monoclonal Antibody'</newAxiom>
<newAxiom>'Amivantamab and Recombinant Human Hyaluronidase' SubClassOf 'Bispecific Monoclonal Antibody'</newAxiom>
<newAxiom>'Amivantamab and Recombinant Human Hyaluronidase' SubClassOf 'Anti-EGFR Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192098</classIRI>
<classLabel>Microcephaly-Capillary Malformation Syndrome</classLabel>
<newAxiom>'Microcephaly-Capillary Malformation Syndrome' SubClassOf 'Syndrome'</newAxiom>
<newAxiom>'Microcephaly-Capillary Malformation Syndrome' SubClassOf 'Disease_Mapped_To_Gene' some 'STAMBP Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192095</classIRI>
<classLabel>Anti-CEA/Anti-4-1BB Bispecific Antibody BGB-B167</classLabel>
<newAxiom>'Anti-CEA/Anti-4-1BB Bispecific Antibody BGB-B167' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-CEA/Anti-4-1BB Bispecific Antibody BGB-B167' SubClassOf 'Anti-CD137 Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-CEA/Anti-4-1BB Bispecific Antibody BGB-B167' SubClassOf 'Bispecific Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192096</classIRI>
<classLabel>Intratubular Embryonal Carcinoma</classLabel>
<newAxiom>'Intratubular Embryonal Carcinoma' EquivalentTo 'Testicular Embryonal Carcinoma' and 'Intratubular Non-Seminoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192094</classIRI>
<classLabel>Retired Concept 2022</classLabel>
<newAxiom>'Retired Concept 2022' SubClassOf 'Retired Concept'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192091</classIRI>
<classLabel>Anti-EGFR/c-Met/TOP1i ADC AZD9592</classLabel>
<newAxiom>'Anti-EGFR/c-Met/TOP1i ADC AZD9592' SubClassOf 'Antineoplastic Antibody-Drug Conjugate'</newAxiom>
<newAxiom>'Anti-EGFR/c-Met/TOP1i ADC AZD9592' SubClassOf 'Immunoconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192092</classIRI>
<classLabel>Xia-Gibbs Syndrome</classLabel>
<newAxiom>'Xia-Gibbs Syndrome' SubClassOf 'Syndrome'</newAxiom>
<newAxiom>'Xia-Gibbs Syndrome' SubClassOf 'Rare Non-Neoplastic Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192090</classIRI>
<classLabel>Neuronal Ceroid Lipofuscinosis Type 5</classLabel>
<newAxiom>'Neuronal Ceroid Lipofuscinosis Type 5' SubClassOf 'Neuronal Ceroid Lipofuscinosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192088</classIRI>
<classLabel>Aortic Valve Disease 1</classLabel>
<newAxiom>'Aortic Valve Disease 1' SubClassOf 'Disease_Mapped_To_Gene' some 'NOTCH1 Gene'</newAxiom>
<newAxiom>'Aortic Valve Disease 1' SubClassOf 'Bicuspid Aortic Valve'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192089</classIRI>
<classLabel>Retinal Cone Dystrophy 3B</classLabel>
<newAxiom>'Retinal Cone Dystrophy 3B' SubClassOf 'Hereditary Retinal Dystrophy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192086</classIRI>
<classLabel>Presence of Open Sores or Red Spots</classLabel>
<newAxiom>'Presence of Open Sores or Red Spots' SubClassOf 'Symptoms Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192087</classIRI>
<classLabel>Developmental and Epileptic Encephalopathy 7</classLabel>
<newAxiom>'Developmental and Epileptic Encephalopathy 7' SubClassOf 'Developmental and Epileptic Encephalopathy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192084</classIRI>
<classLabel>Severity of Skin Itchiness</classLabel>
<newAxiom>'Severity of Skin Itchiness' SubClassOf 'Severity Question'</newAxiom>
<newAxiom>'Severity of Skin Itchiness' SubClassOf 'Itching Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192085</classIRI>
<classLabel>Presence of Hives</classLabel>
<newAxiom>'Presence of Hives' SubClassOf 'Symptoms Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192082</classIRI>
<classLabel>Dilated Cardiomyopathy-1HH</classLabel>
<newAxiom>'Dilated Cardiomyopathy-1HH' SubClassOf 'Dilated Cardiomyopathy'</newAxiom>
<newAxiom>'Dilated Cardiomyopathy-1HH' SubClassOf 'Disease_Mapped_To_Gene' some 'BAG3 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192083</classIRI>
<classLabel>Severity of Cough</classLabel>
<newAxiom>'Severity of Cough' SubClassOf 'Severity Question'</newAxiom>
<newAxiom>'Severity of Cough' SubClassOf 'Cough Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192080</classIRI>
<classLabel>Severity of Muscle Pain</classLabel>
<newAxiom>'Severity of Muscle Pain' SubClassOf 'Pain Question'</newAxiom>
<newAxiom>'Severity of Muscle Pain' SubClassOf 'Severity Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192081</classIRI>
<classLabel>Severity of Abdominal Pain</classLabel>
<newAxiom>'Severity of Abdominal Pain' SubClassOf 'Pain Question'</newAxiom>
<newAxiom>'Severity of Abdominal Pain' SubClassOf 'Severity Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192079</classIRI>
<classLabel>Severity of Joint Pain</classLabel>
<newAxiom>'Severity of Joint Pain' SubClassOf 'Severity Question'</newAxiom>
<newAxiom>'Severity of Joint Pain' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192077</classIRI>
<classLabel>Frequency of Muscle Pain</classLabel>
<newAxiom>'Frequency of Muscle Pain' SubClassOf 'Pain Question'</newAxiom>
<newAxiom>'Frequency of Muscle Pain' SubClassOf 'Frequency Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192078</classIRI>
<classLabel>Frequency of Joint Pain</classLabel>
<newAxiom>'Frequency of Joint Pain' SubClassOf 'Pain Question'</newAxiom>
<newAxiom>'Frequency of Joint Pain' SubClassOf 'Frequency Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192075</classIRI>
<classLabel>Extent that Joint Pain Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Joint Pain Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
<newAxiom>'Extent that Joint Pain Interfered with Usual Activities' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192076</classIRI>
<classLabel>Frequency of Abdominal Pain</classLabel>
<newAxiom>'Frequency of Abdominal Pain' SubClassOf 'Frequency Question'</newAxiom>
<newAxiom>'Frequency of Abdominal Pain' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192073</classIRI>
<classLabel>Extent that Hand or Foot Numbness or Tingling Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Hand or Foot Numbness or Tingling Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
<newAxiom>'Extent that Hand or Foot Numbness or Tingling Interfered with Usual Activities' SubClassOf 'Numbness or Tingling Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192074</classIRI>
<classLabel>Extent that Muscle Pain Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Muscle Pain Interfered with Usual Activities' SubClassOf 'Pain Question'</newAxiom>
<newAxiom>'Extent that Muscle Pain Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192071</classIRI>
<classLabel>Extent that Coughing Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Coughing Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
<newAxiom>'Extent that Coughing Interfered with Usual Activities' SubClassOf 'Cough Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192072</classIRI>
<classLabel>Extent that Itchy Skin Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Itchy Skin Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192070</classIRI>
<classLabel>Extent that Stomach Pain Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Stomach Pain Interfered with Usual Activities' SubClassOf 'Pain Question'</newAxiom>
<newAxiom>'Extent that Stomach Pain Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192068</classIRI>
<classLabel>Extent that Constipation Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Constipation Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192069</classIRI>
<classLabel>Extent that Diarrhea Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Diarrhea Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
<newAxiom>'Extent that Diarrhea Interfered with Usual Activities' SubClassOf 'Diarrhea Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192066</classIRI>
<classLabel>Extent that Nausea Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Nausea Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
<newAxiom>'Extent that Nausea Interfered with Usual Activities' SubClassOf 'Nausea Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192067</classIRI>
<classLabel>Extent that Vomiting Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Vomiting Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
<newAxiom>'Extent that Vomiting Interfered with Usual Activities' SubClassOf 'Vomiting Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192064</classIRI>
<classLabel>Extent that Mouth or Throat Pain Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Mouth or Throat Pain Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
<newAxiom>'Extent that Mouth or Throat Pain Interfered with Usual Activities' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192065</classIRI>
<classLabel>Extent that Change in Taste of Food or Drink Interfered with Eating Usual Food</classLabel>
<newAxiom>'Extent that Change in Taste of Food or Drink Interfered with Eating Usual Food' SubClassOf 'Extent Question'</newAxiom>
<newAxiom>'Extent that Change in Taste of Food or Drink Interfered with Eating Usual Food' SubClassOf 'Taste Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192062</classIRI>
<classLabel>Extent that Dry Mouth Interfered with Usual Activities</classLabel>
<newAxiom>'Extent that Dry Mouth Interfered with Usual Activities' SubClassOf 'Extent Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192063</classIRI>
<classLabel>Frequency of Mouth or Throat Pain</classLabel>
<newAxiom>'Frequency of Mouth or Throat Pain' SubClassOf 'Pain Question'</newAxiom>
<newAxiom>'Frequency of Mouth or Throat Pain' SubClassOf 'Frequency Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192060</classIRI>
<classLabel>Severity Question</classLabel>
<newAxiom>'Severity Question' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192061</classIRI>
<classLabel>Severity of Dry Mouth</classLabel>
<newAxiom>'Severity of Dry Mouth' SubClassOf 'Severity Question'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
</deletedClasses>
</diffReport>