<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
243
</numberChangedClasses>
<numberNewClasses>
587
</numberNewClasses>
<numberDeletedClasses>
0
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28440</classIRI>
<classLabel>Small Nuclear Ribonucleoprotein Particle</classLabel>
<deletedAxiom>&apos;Small Nuclear Ribonucleoprotein Particle&apos; SubClassOf &apos;Protein or Riboprotein Complex&apos;</deletedAxiom>
<newAxiom>&apos;Small Nuclear Ribonucleoprotein Particle&apos; SubClassOf &apos;Ribonucleoprotein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28452</classIRI>
<classLabel>Philadelphia Chromosome</classLabel>
<deletedAxiom>&apos;Philadelphia Chromosome&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;BCR Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;Philadelphia Chromosome&apos; SubClassOf &apos;Cytogenetic_Abnormality_Involves_Chromosome&apos; some &apos;Chromosome 22&apos;</deletedAxiom>
<newAxiom>&apos;Philadelphia Chromosome&apos; SubClassOf &apos;BCR Gene Rearrangement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3342</classIRI>
<classLabel>Lactotroph Adenoma</classLabel>
<deletedAxiom>&apos;Lactotroph Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and &apos;Prolactin-Producing Pituitary Gland Neoplasm&apos; and (&apos;Disease_Excludes_Finding&apos; some &apos;Growth Hormone and Prolactin-Producing Neoplastic Cells Present&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Giant Mitochondria Present&apos;)</deletedAxiom>
<newAxiom>&apos;Lactotroph Adenoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187086 and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Lactotroph Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Lactotroph Cell&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Growth Hormone and Prolactin-Producing Neoplastic Cells Present&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Giant Mitochondria Present&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3329</classIRI>
<classLabel>Pituitary Gland Adenoma</classLabel>
<deletedAxiom>&apos;Pituitary Gland Adenoma&apos; EquivalentTo &apos;Adenoma&apos; and &apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Malignant Adenohypophysial Cell&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Metastatic Lesion&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;Pituitary Tumor Transforming Gene Overexpression&apos;)</deletedAxiom>
<newAxiom>&apos;Pituitary Gland Adenoma&apos; EquivalentTo &apos;Adenoma&apos; and &apos;Neuroendocrine Neoplasm&apos; and &apos;Anterior Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Glandular Epithelial Tissue&apos;) and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Adenohypophysial Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Adenohypophysial Cell&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3330</classIRI>
<classLabel>Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;Pituitary Gland Neoplasm&apos; EquivalentTo &apos;Pituitary Gland Disorder&apos; and &apos;Head and Neck Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Pituitary Gland Neoplasm&apos; EquivalentTo &apos;Pituitary Gland Disorder&apos; and &apos;Sellar Region Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3168</classIRI>
<classLabel>Childhood Acute Lymphoblastic Leukemia</classLabel>
<deletedAxiom>&apos;Childhood Acute Lymphoblastic Leukemia&apos; EquivalentTo &apos;Acute Lymphoblastic Leukemia&apos; and &apos;Childhood Leukemia&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Acute Lymphoblastic Leukemia&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187056 and &apos;Acute Lymphoblastic Leukemia&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14315</classIRI>
<classLabel>Canarypox Virus</classLabel>
<deletedAxiom>&apos;Canarypox Virus&apos; SubClassOf &apos;Poxvirus&apos;</deletedAxiom>
<newAxiom>&apos;Canarypox Virus&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187440</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C119274</classIRI>
<classLabel>Beta-1 Globulin Measurement</classLabel>
<newAxiom>&apos;Beta-1 Globulin Measurement&apos; SubClassOf &apos;Protein or Enzyme Type Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C119275</classIRI>
<classLabel>Beta-1 Globulin to Total Protein Ratio Measurement</classLabel>
<newAxiom>&apos;Beta-1 Globulin to Total Protein Ratio Measurement&apos; SubClassOf &apos;Protein or Enzyme Type Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C119276</classIRI>
<classLabel>Beta-2 Globulin Measurement</classLabel>
<newAxiom>&apos;Beta-2 Globulin Measurement&apos; SubClassOf &apos;Protein or Enzyme Type Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C119277</classIRI>
<classLabel>Beta-2 Globulin to Total Protein Ratio Measurement</classLabel>
<newAxiom>&apos;Beta-2 Globulin to Total Protein Ratio Measurement&apos; SubClassOf &apos;Protein or Enzyme Type Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158840</classIRI>
<classLabel>Transcriptional Enhancer Factor TEF-3</classLabel>
<deletedAxiom>&apos;Transcriptional Enhancer Factor TEF-3&apos; EquivalentTo &apos;Transcription Factor&apos; and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TEAD4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Transcriptional Enhancer Factor TEF-3&apos; EquivalentTo &apos;Transcription Factor&apos; and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187385) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Skeletal Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TEAD4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158500</classIRI>
<classLabel>Globozoospermia</classLabel>
<newAxiom>&apos;Globozoospermia&apos; SubClassOf &apos;Male Reproductive System Finding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C124993</classIRI>
<classLabel>Amivantamab</classLabel>
<newAxiom>&apos;Amivantamab&apos; SubClassOf &apos;Anti-c-Met Monoclonal Antibody&apos;</newAxiom>
<newAxiom>&apos;Amivantamab&apos; SubClassOf &apos;Anti-EGFR Monoclonal Antibody&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158155</classIRI>
<classLabel>Geriatric Depression Scale Short Form - Total Score</classLabel>
<deletedAxiom>&apos;Geriatric Depression Scale Short Form - Total Score&apos; SubClassOf &apos;Geriatric Depression Scale Short Form Questionnaire Question&apos;</deletedAxiom>
<newAxiom>&apos;Geriatric Depression Scale Short Form - Total Score&apos; SubClassOf &apos;GDS-SF Questionnaire Question&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158127</classIRI>
<classLabel>Geriatric Depression Scale Short Form Questionnaire Question</classLabel>
<deletedAxiom>&apos;Geriatric Depression Scale Short Form Questionnaire Question&apos; SubClassOf &apos;Clinical or Research Assessment Question&apos;</deletedAxiom>
<newAxiom>&apos;Geriatric Depression Scale Short Form Questionnaire Question&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48458</classIRI>
<classLabel>Non-Functioning Adrenal Cortex Adenoma</classLabel>
<deletedAxiom>&apos;Non-Functioning Adrenal Cortex Adenoma&apos; EquivalentTo &apos;Adrenal Cortex Adenoma&apos; and &apos;Non-Functioning Endocrine Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Absence of a Hormonal Syndrome&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;CTNNB1 Gene&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;CTNNB1 Gene Mutation&apos;)</deletedAxiom>
<newAxiom>&apos;Non-Functioning Adrenal Cortex Adenoma&apos; EquivalentTo &apos;Adrenal Cortex Adenoma&apos; and &apos;Non-Functioning Endocrine Neoplasm&apos; and (&apos;Disease_Mapped_To_Gene&apos; some &apos;CTNNB1 Gene&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;CTNNB1 Gene Mutation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3997</classIRI>
<classLabel>Childhood Medulloblastoma</classLabel>
<deletedAxiom>&apos;Childhood Medulloblastoma&apos; EquivalentTo &apos;Childhood Central Nervous System Embryonal Tumor&apos; and &apos;Medulloblastoma&apos; and &apos;Childhood Cerebellar Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Medulloblastoma&apos; EquivalentTo &apos;Childhood Central Nervous System Embryonal Tumor&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Medulloblastoma&apos; and &apos;Childhood Cerebellar Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3879</classIRI>
<classLabel>Thyroid Gland Medullary Carcinoma</classLabel>
<deletedAxiom>&apos;Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Head and Neck Neuroendocrine Carcinoma&apos; and &apos;Thyroid Gland Carcinoma&apos; and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Thyroid Gland Follicle&apos;) and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;C-Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Serum Calcitonin Level Increased&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Calcitonin Positive Neoplastic Cells Present&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Malignant Neuroendocrine Spindle Cell&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Malignant Neuroendocrine Polygonal Cell&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Malignant Neuroendocrine Small Round Cell&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Cold Nodule&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Trabecular Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Organoid Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Metastatic Malignant Neoplasm in the Lymph Nodes&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Paraneoplastic Syndrome&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;RET Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Thyroid Gland Medullary Carcinoma&apos; EquivalentTo &apos;Head and Neck Neuroendocrine Carcinoma&apos; and &apos;Thyroid Gland Carcinoma&apos; and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Thyroid Gland Follicle&apos;) and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;C-Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Serum Calcitonin Level Increased&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Calcitonin Positive Neoplastic Cells Present&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Malignant Neuroendocrine Spindle Cell&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Malignant Neuroendocrine Polygonal Cell&apos;) and (&apos;Disease_May_Have_Abnormal_Cell&apos; some &apos;Malignant Neuroendocrine Small Round Cell&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Cold Nodule&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Trabecular Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Organoid Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Metastatic Malignant Neoplasm in the Lymph Nodes&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Paraneoplastic Syndrome&apos;) and (&apos;Disease_Excludes_Primary_Anatomic_Site&apos; some &apos;Pituitary Gland&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;RET Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73940</classIRI>
<classLabel>EBV-Positive Neoplastic Cells Present</classLabel>
<newAxiom>&apos;EBV-Positive Neoplastic Cells Present&apos; SubClassOf &apos;Epstein-Barr Virus Positive&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125509</classIRI>
<classLabel>Confident That I Can Get the Medical Care I Need Without Being Set Back Financially</classLabel>
<newAxiom>&apos;Confident That I Can Get the Medical Care I Need Without Being Set Back Financially&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C125207</classIRI>
<classLabel>Anti-Chimeric Antigen Receptor Antibody</classLabel>
<deletedAxiom>&apos;Anti-Chimeric Antigen Receptor Antibody&apos; SubClassOf &apos;Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Anti-Chimeric Antigen Receptor Antibody&apos; SubClassOf &apos;Anti-Drug Antibody&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20125</classIRI>
<classLabel>Tankyrase-1</classLabel>
<deletedAxiom>&apos;Tankyrase-1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SAM Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Telomere Maintenance&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Spindle Assembly Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNKS Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Tankyrase-1&apos; EquivalentTo &apos;Glycosyltransferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomere Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Telomerase Regulation Pathway&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;SAM Domain&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ankyrin Repeat&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ubiquitination Regulation Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Poly-ADP-Ribosylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Telomere Maintenance&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Spindle Assembly Interaction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;TNKS Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178589</classIRI>
<classLabel>Anti-CD19/CD3 Bispecific Antibody GNR-084</classLabel>
<deletedAxiom>&apos;Anti-CD19/CD3 Bispecific Antibody GNR-084&apos; SubClassOf &apos;Antineoplastic Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Anti-CD19/CD3 Bispecific Antibody GNR-084&apos; SubClassOf &apos;Anti-CD19 Monoclonal Antibody&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178577</classIRI>
<classLabel>Anti-CD19/CD3 Bispecific Antibody TNB-486</classLabel>
<deletedAxiom>&apos;Anti-CD19/CD3 Bispecific Antibody TNB-486&apos; SubClassOf &apos;Antineoplastic Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Anti-CD19/CD3 Bispecific Antibody TNB-486&apos; SubClassOf &apos;Anti-CD19 Monoclonal Antibody&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105560</classIRI>
<classLabel>TRDMT1 Gene</classLabel>
<newAxiom>&apos;TRDMT1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Post-Transcriptional Regulation&apos;</newAxiom>
<newAxiom>&apos;TRDMT1 Gene&apos; SubClassOf &apos;Translation Process Gene&apos;</newAxiom>
<newAxiom>&apos;TRDMT1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;RNA Synthesis&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105562</classIRI>
<classLabel>tRNA (Cytosine(38)-C(5))-Methyltransferase</classLabel>
<newAxiom>&apos;tRNA (Cytosine(38)-C(5))-Methyltransferase&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Synthesis&apos;</newAxiom>
<newAxiom>&apos;tRNA (Cytosine(38)-C(5))-Methyltransferase&apos; SubClassOf &apos;Translation Process Protein&apos;</newAxiom>
<newAxiom>&apos;tRNA (Cytosine(38)-C(5))-Methyltransferase&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Transcriptional Regulation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54217</classIRI>
<classLabel>t(11;19)(q21;p13)</classLabel>
<newAxiom>&apos;t(11;19)(q21;p13)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;CRTC1/MAML2 Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29615</classIRI>
<classLabel>Fatty Acid-Binding Protein, Liver</classLabel>
<deletedAxiom>&apos;Fatty Acid-Binding Protein, Liver&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FABP1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fatty Acid-Binding Protein, Liver&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR-alpha Gene Regulation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FABP1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29616</classIRI>
<classLabel>Fatty Acid-Binding Protein, Intestinal</classLabel>
<deletedAxiom>&apos;Fatty Acid-Binding Protein, Intestinal&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FABP2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fatty Acid-Binding Protein, Intestinal&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FABP2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29617</classIRI>
<classLabel>Fatty Acid-Binding Protein, Adipocyte</classLabel>
<deletedAxiom>&apos;Fatty Acid-Binding Protein, Adipocyte&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Nuclear Localization Signal&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Transport&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FABP4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Fatty Acid-Binding Protein, Adipocyte&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PPAR Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoplasm&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Nuclear Localization Signal&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Transport&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Fatty Acid Metabolism&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;FABP4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157620</classIRI>
<classLabel>Illness is Financial Hardship for My Family and Me</classLabel>
<newAxiom>&apos;Illness is Financial Hardship for My Family and Me&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157451</classIRI>
<classLabel>SDHAF2 Gene Mutation</classLabel>
<newAxiom>&apos;SDHAF2 Gene Mutation&apos; SubClassOf &apos;SDH Complex Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C182422</classIRI>
<classLabel>Agree with Prior CRF</classLabel>
<deletedAxiom>&apos;Agree with Prior CRF&apos; SubClassOf &apos;Clinical or Research Assessment Question&apos;</deletedAxiom>
<newAxiom>&apos;Agree with Prior CRF&apos; SubClassOf &apos;Agreement Question&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49447</classIRI>
<classLabel>CDK11B wt Allele</classLabel>
<deletedAxiom>&apos;CDK11B wt Allele&apos; EquivalentTo &apos;CDK11B Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 1686433-1666482&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p36&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</deletedAxiom>
<newAxiom>&apos;CDK11B wt Allele&apos; EquivalentTo &apos;CDK11B Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;HIV-I Nef in Apoptosis Pathway&apos;) and (&apos;Gene_Has_Physical_Location&apos; some &apos;1: 1686433-1666482&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;1p36.33&apos;) and (&apos;Gene_Found_In_Organism&apos; some &apos;Human&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74804</classIRI>
<classLabel>Cytokine Measurement</classLabel>
<newAxiom>&apos;Cytokine Measurement&apos; SubClassOf &apos;Protein or Enzyme Type Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C124272</classIRI>
<classLabel>Childhood Central Nervous System Ganglioneuroblastoma</classLabel>
<deletedAxiom>&apos;Childhood Central Nervous System Ganglioneuroblastoma&apos; EquivalentTo &apos;Childhood Central Nervous System Embryonal Tumor&apos; and &apos;Childhood Ganglioneuroblastoma&apos; and &apos;Childhood Supratentorial Neoplasm&apos; and &apos;Central Nervous System Ganglioneuroblastoma&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Central Nervous System Ganglioneuroblastoma&apos; EquivalentTo &apos;Childhood Central Nervous System Embryonal Tumor&apos; and &apos;Childhood Ganglioneuroblastoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Childhood Supratentorial Neoplasm&apos; and &apos;Central Nervous System Ganglioneuroblastoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C124292</classIRI>
<classLabel>Childhood Choroid Plexus Carcinoma</classLabel>
<deletedAxiom>&apos;Childhood Choroid Plexus Carcinoma&apos; EquivalentTo &apos;Childhood Choroid Plexus Neoplasm&apos; and &apos;Choroid Plexus Carcinoma&apos; and &apos;Malignant Supratentorial Neoplasm&apos; and &apos;Malignant Childhood Central Nervous System Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Choroid Plexus Carcinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Childhood Choroid Plexus Neoplasm&apos; and &apos;Choroid Plexus Carcinoma&apos; and &apos;Malignant Supratentorial Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163956</classIRI>
<classLabel>Locally Advanced Pituitary Neuroendocrine Tumor</classLabel>
<deletedAxiom>&apos;Locally Advanced Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Locally Advanced Head and Neck Carcinoma&apos; and &apos;Locally Advanced Primary Malignant Central Nervous System Neoplasm&apos; and &apos;Locally Advanced Adenocarcinoma&apos; and &apos;Metastatic Pituitary Neuroendocrine Tumor&apos;</deletedAxiom>
<newAxiom>&apos;Locally Advanced Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Locally Advanced Head and Neck Carcinoma&apos; and &apos;Locally Advanced Neuroendocrine Carcinoma&apos; and &apos;Locally Advanced Primary Malignant Central Nervous System Neoplasm&apos; and &apos;Metastatic Pituitary Neuroendocrine Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163959</classIRI>
<classLabel>Unresectable Metastatic Pituitary Neuroendocrine Tumor</classLabel>
<deletedAxiom>&apos;Unresectable Metastatic Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Metastatic Unresectable Carcinoma&apos; and &apos;Unresectable Head and Neck Carcinoma&apos; and &apos;Metastatic Pituitary Neuroendocrine Tumor&apos;</deletedAxiom>
<newAxiom>&apos;Unresectable Metastatic Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Metastatic Unresectable Carcinoma&apos; and &apos;Head and Neck Neuroendocrine Carcinoma&apos; and &apos;Unresectable Head and Neck Carcinoma&apos; and &apos;Unresectable Neuroendocrine Carcinoma&apos; and &apos;Metastatic Pituitary Neuroendocrine Tumor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2969</classIRI>
<classLabel>Cushing Syndrome</classLabel>
<deletedAxiom>&apos;Cushing Syndrome&apos; SubClassOf &apos;Disease_May_Have_Associated_Disease&apos; some &apos;ACTH-Producing Pituitary Gland Neoplasm&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C163780</classIRI>
<classLabel>How Much Does Illness and/or Treatment Interfere with Financial Situation</classLabel>
<newAxiom>&apos;How Much Does Illness and/or Treatment Interfere with Financial Situation&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21235</classIRI>
<classLabel>TNKS Gene</classLabel>
<newAxiom>&apos;TNKS Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Poly-ADP-Ribosylation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94540</classIRI>
<classLabel>Anterior Pituitary Gland Endocrine Neoplasm</classLabel>
<deletedAxiom>&apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; EquivalentTo &apos;Endocrine Neoplasm&apos; and &apos;Anterior Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Glandular Epithelial Tissue&apos;) and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Adenohypophysial Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Adenohypophysial Cell&apos;)</deletedAxiom>
<newAxiom>&apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94537</classIRI>
<classLabel>Spindle Cell Oncocytoma</classLabel>
<deletedAxiom>&apos;Spindle Cell Oncocytoma&apos; EquivalentTo &apos;Skull Base Neoplasm&apos; and &apos;Oncocytic Neoplasm&apos; and &apos;Posterior Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Eosinophilic Spindle Cell&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 1&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Aggressive Clinical Course&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Metastatic Lesion&apos;)</deletedAxiom>
<newAxiom>&apos;Spindle Cell Oncocytoma&apos; EquivalentTo &apos;Oncocytic Neoplasm&apos; and &apos;Posterior Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Eosinophilic Spindle Cell&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 1&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Aggressive Clinical Course&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Metastatic Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94524</classIRI>
<classLabel>Pituicytoma</classLabel>
<deletedAxiom>&apos;Pituicytoma&apos; EquivalentTo &apos;Posterior Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Elongated Glial Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Slow Growing Mass&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Headache&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Visual Disturbance&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Amenorrhea&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Decreased Libido&apos;)</deletedAxiom>
<newAxiom>&apos;Pituicytoma&apos; EquivalentTo &apos;Posterior Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Elongated Glial Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Slow Growing Mass&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;Grade 1&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21583</classIRI>
<classLabel>Calcium Signal-Modulating Cyclophilin Ligand</classLabel>
<deletedAxiom>&apos;Calcium Signal-Modulating Cyclophilin Ligand&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;T-Lymphocyte&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CAMLG Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Calcium Signal-Modulating Cyclophilin Ligand&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Ovary&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Testis&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Brain&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;T-Lymphocyte&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;T-Cell Activation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Calcium Signaling&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CAMLG Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104604</classIRI>
<classLabel>Concern About Finances</classLabel>
<newAxiom>&apos;Concern About Finances&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80068</classIRI>
<classLabel>RAG1 Gene</classLabel>
<newAxiom>&apos;RAG1 Gene&apos; SubClassOf &apos;Ubiquitin-Transferase Gene&apos;</newAxiom>
<newAxiom>&apos;RAG1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Monoubiquitination&apos;</newAxiom>
<newAxiom>&apos;RAG1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;DNA Recombination Process&apos;</newAxiom>
<newAxiom>&apos;RAG1 Gene&apos; SubClassOf &apos;Esterase Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80069</classIRI>
<classLabel>RAG2 Gene</classLabel>
<newAxiom>&apos;RAG2 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;DNA Recombination Process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80071</classIRI>
<classLabel>RAG2 wt Allele</classLabel>
<newAxiom>&apos;RAG2 wt Allele&apos; SubClassOf &apos;Gene_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80072</classIRI>
<classLabel>V(D)J Recombination-Activating Protein 1</classLabel>
<deletedAxiom>&apos;V(D)J Recombination-Activating Protein 1&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAG1 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;V(D)J Recombination-Activating Protein 1&apos; SubClassOf &apos;Immunoprotein&apos;</deletedAxiom>
<deletedAxiom>&apos;V(D)J Recombination-Activating Protein 1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;V(D)J Recombination&apos;</deletedAxiom>
<newAxiom>&apos;V(D)J Recombination-Activating Protein 1&apos; EquivalentTo &apos;Esterase&apos; and &apos;Immunoprotein&apos; and &apos;E3 Ubiquitin-Protein Transferase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;V(D)J Recombination&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Monoubiquitination&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAG1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80073</classIRI>
<classLabel>V(D)J Recombination-Activating Protein 2</classLabel>
<newAxiom>&apos;V(D)J Recombination-Activating Protein 2&apos; SubClassOf &apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;</newAxiom>
<newAxiom>&apos;V(D)J Recombination-Activating Protein 2&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;DNA Recombination Process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80070</classIRI>
<classLabel>RAG1 wt Allele</classLabel>
<deletedAxiom>&apos;RAG1 wt Allele&apos; SubClassOf &apos;RAG1 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;RAG1 wt Allele&apos; SubClassOf &apos;Gene_In_Chromosomal_Location&apos; some &apos;11p13&apos;</deletedAxiom>
<newAxiom>&apos;RAG1 wt Allele&apos; EquivalentTo &apos;RAG1 Gene&apos; and (&apos;Gene_Is_Element_In_Pathway&apos; some &apos;Primary Immunodeficiency Pathway&apos;) and (&apos;Gene_In_Chromosomal_Location&apos; some &apos;11p13&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80187</classIRI>
<classLabel>HDL-Cholesterol Subclass 2 Measurement</classLabel>
<deletedAxiom>&apos;HDL-Cholesterol Subclass 2 Measurement&apos; SubClassOf &apos;Lipid Measurement&apos;</deletedAxiom>
<newAxiom>&apos;HDL-Cholesterol Subclass 2 Measurement&apos; SubClassOf &apos;High Density Lipoprotein Cholesterol Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80188</classIRI>
<classLabel>HDL-Cholesterol Subclass 3 Measurement</classLabel>
<deletedAxiom>&apos;HDL-Cholesterol Subclass 3 Measurement&apos; SubClassOf &apos;Lipid Measurement&apos;</deletedAxiom>
<newAxiom>&apos;HDL-Cholesterol Subclass 3 Measurement&apos; SubClassOf &apos;High Density Lipoprotein Cholesterol Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177476</classIRI>
<classLabel>ERBB2 NM_004448.3:c.2305GA</classLabel>
<newAxiom>&apos;ERBB2 NM_004448.3:c.2305GA&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187198</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177480</classIRI>
<classLabel>ERBB2 NM_004448.3:c.2301CG</classLabel>
<newAxiom>&apos;ERBB2 NM_004448.3:c.2301CG&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187198</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104570</classIRI>
<classLabel>NOX4 Gene</classLabel>
<newAxiom>&apos;NOX4 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Free Radical Formation&apos;</newAxiom>
<newAxiom>&apos;NOX4 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Signal Transduction&apos;</newAxiom>
<newAxiom>&apos;NOX4 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Regulatory Process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104571</classIRI>
<classLabel>NOX4 wt Allele</classLabel>
<newAxiom>&apos;NOX4 wt Allele&apos; SubClassOf &apos;Gene_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104572</classIRI>
<classLabel>NADPH Oxidase 4</classLabel>
<deletedAxiom>&apos;NADPH Oxidase 4&apos; SubClassOf &apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;NADPH Oxidase Complex&apos;</deletedAxiom>
<deletedAxiom>&apos;NADPH Oxidase 4&apos; SubClassOf &apos;Oxidoreductase&apos;</deletedAxiom>
<deletedAxiom>&apos;NADPH Oxidase 4&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NOX4 Gene&apos;</deletedAxiom>
<newAxiom>&apos;NADPH Oxidase 4&apos; EquivalentTo &apos;Oxidoreductase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Alzheimer&apos;s Disease Pathway KEGG&apos;) and (&apos;Gene_Product_Has_Chemical_Classification&apos; some &apos;Transmembrane Protein&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Rough Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Membrane of the Smooth Endoplasmic Reticulum&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Transmembrane Domain&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;NADPH Oxidase Complex&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Free Radical Formation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Regulatory Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;NOX4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104397</classIRI>
<classLabel>FSHB Gene</classLabel>
<deletedAxiom>&apos;FSHB Gene&apos; SubClassOf &apos;Protein Complex Subunit Gene&apos;</deletedAxiom>
<newAxiom>&apos;FSHB Gene&apos; SubClassOf &apos;Peptide Hormone Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C166167</classIRI>
<classLabel>MAP2K2 NM_030662.3:c.383CT</classLabel>
<newAxiom>&apos;MAP2K2 NM_030662.3:c.383CT&apos; SubClassOf &apos;Non-synonymous MAP2K Family Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16257</classIRI>
<classLabel>Actin-Binding Protein</classLabel>
<deletedAxiom>&apos;Actin-Binding Protein&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cytoskeletal Protein&apos;</deletedAxiom>
<deletedAxiom>&apos;Actin-Binding Protein&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Cytoskeleton&apos;</deletedAxiom>
<newAxiom>&apos;Actin-Binding Protein&apos; SubClassOf &apos;Cytoskeletal Protein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16278</classIRI>
<classLabel>Alpha-Fetoprotein</classLabel>
<deletedAxiom>&apos;Alpha-Fetoprotein&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA2 and FOXA3 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glucocorticoid Receptor Regulatory Network&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Fetus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Yolk Sac&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hepatocellular Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Teratoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metal Ion Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AFP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Alpha-Fetoprotein&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;p53 Effector Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;FOXA2 and FOXA3 Transcription Factor Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Glucocorticoid Receptor Regulatory Network&apos;) and (&apos;Gene_Product_Is_Biomarker_Type&apos; some &apos;Tumor Marker&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Fetus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Yolk Sac&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Hepatocellular Carcinoma&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Teratoma&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Liver&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Metal Ion Binding&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Lipid Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;AFP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16218</classIRI>
<classLabel>Nerve-Sparing Prostatectomy</classLabel>
<deletedAxiom>&apos;Nerve-Sparing Prostatectomy&apos; SubClassOf &apos;Prostatectomy&apos;</deletedAxiom>
<newAxiom>&apos;Nerve-Sparing Prostatectomy&apos; SubClassOf &apos;Radical Prostatectomy&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5963</classIRI>
<classLabel>Metastatic Growth Hormone-Producing Pituitary Neuroendocrine Tumor</classLabel>
<deletedAxiom>&apos;Metastatic Growth Hormone-Producing Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Metastatic Pituitary Neuroendocrine Tumor&apos; and &apos;Growth Hormone-Producing Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Somatotroph Cell&apos;)</deletedAxiom>
<newAxiom>&apos;Metastatic Growth Hormone-Producing Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Metastatic Pituitary Neuroendocrine Tumor&apos; and &apos;Somatotroph Adenoma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Somatotroph Cell&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5962</classIRI>
<classLabel>Metastatic Prolactin-Producing Pituitary Neuroendocrine Tumor</classLabel>
<deletedAxiom>&apos;Metastatic Prolactin-Producing Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Metastatic Pituitary Neuroendocrine Tumor&apos; and &apos;Prolactin-Producing Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Lactotroph Cell&apos;)</deletedAxiom>
<newAxiom>&apos;Metastatic Prolactin-Producing Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Lactotroph Adenoma&apos; and &apos;Metastatic Pituitary Neuroendocrine Tumor&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Lactotroph Cell&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5964</classIRI>
<classLabel>Metastatic ACTH-Producing Pituitary Neuroendocrine Tumor</classLabel>
<deletedAxiom>&apos;Metastatic ACTH-Producing Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Metastatic Pituitary Neuroendocrine Tumor&apos; and &apos;ACTH-Producing Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Corticotroph Cell&apos;)</deletedAxiom>
<newAxiom>&apos;Metastatic ACTH-Producing Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Metastatic Pituitary Neuroendocrine Tumor&apos; and &apos;Corticotroph Adenoma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Corticotroph Cell&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16717</classIRI>
<classLabel>Immunoglobulin Heavy Chain</classLabel>
<deletedAxiom>&apos;Immunoglobulin Heavy Chain&apos; EquivalentTo &apos;Protein Complex Subunit&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Constant Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Joining Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Variable Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Fc&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Hypervariable Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Hinge Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Heavy Chain Diversity Region&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Immunoglobulin&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Immunoprotein&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Humoral Immunity&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;Immunoglobulin Heavy Locus&apos;)</deletedAxiom>
<newAxiom>&apos;Immunoglobulin Heavy Chain&apos; EquivalentTo &apos;Immunoprotein&apos; and &apos;Protein Complex Subunit&apos; and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Constant Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Joining Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Variable Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Fc&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Hypervariable Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Hinge Region&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Immunoglobulin Heavy Chain Diversity Region&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some &apos;Immunoglobulin&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Humoral Immunity&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immune Response Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;Immunoglobulin Heavy Locus&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16720</classIRI>
<classLabel>Immunoglobulin Light Chain</classLabel>
<newAxiom>&apos;Immunoglobulin Light Chain&apos; SubClassOf &apos;Immunoprotein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132412</classIRI>
<classLabel>Periureteral Region</classLabel>
<deletedAxiom>&apos;Periureteral Region&apos; SubClassOf &apos;Body Region&apos;</deletedAxiom>
<newAxiom>&apos;Periureteral Region&apos; SubClassOf &apos;Genito-Urinary Region&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C107171</classIRI>
<classLabel>Distress over Practical Problem with Insurance or Finances</classLabel>
<newAxiom>&apos;Distress over Practical Problem with Insurance or Finances&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61042</classIRI>
<classLabel>Serum LDL Cholesterol Measurement</classLabel>
<deletedAxiom>&apos;Serum LDL Cholesterol Measurement&apos; SubClassOf &apos;Lipid Measurement&apos;</deletedAxiom>
<newAxiom>&apos;Serum LDL Cholesterol Measurement&apos; SubClassOf &apos;Low Density Lipoprotein Cholesterol Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61041</classIRI>
<classLabel>Serum HDL Cholesterol Measurement</classLabel>
<deletedAxiom>&apos;Serum HDL Cholesterol Measurement&apos; SubClassOf &apos;Lipid Measurement&apos;</deletedAxiom>
<newAxiom>&apos;Serum HDL Cholesterol Measurement&apos; SubClassOf &apos;High Density Lipoprotein Cholesterol Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61032</classIRI>
<classLabel>Serum Total Cholesterol Measurement</classLabel>
<deletedAxiom>&apos;Serum Total Cholesterol Measurement&apos; SubClassOf &apos;Lipid Measurement&apos;</deletedAxiom>
<newAxiom>&apos;Serum Total Cholesterol Measurement&apos; SubClassOf &apos;Cholesterol Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185602</classIRI>
<classLabel>Anti-CD3/Anti-Claudin18.2 Bispecific Antibody IBI389</classLabel>
<deletedAxiom>&apos;Anti-CD3/Anti-Claudin18.2 Bispecific Antibody IBI389&apos; SubClassOf &apos;Antineoplastic Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Anti-CD3/Anti-Claudin18.2 Bispecific Antibody IBI389&apos; SubClassOf &apos;Anti-claudin18.2 Monoclonal Antibody&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C171060</classIRI>
<classLabel>Low ADAMTS13 Activity</classLabel>
<newAxiom>&apos;Low ADAMTS13 Activity&apos; SubClassOf &apos;Enzyme Deficiency&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36361</classIRI>
<classLabel>t(17;19)(q22;p13)</classLabel>
<newAxiom>&apos;t(17;19)(q22;p13)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;TCF3/HLF Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36363</classIRI>
<classLabel>t(11;17)(q23;q21)</classLabel>
<newAxiom>&apos;t(11;17)(q23;q21)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;RARA/ZBTB16 Fusion Gene&apos;</newAxiom>
<newAxiom>&apos;t(11;17)(q23;q21)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;ZBTB16/RARA Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36362</classIRI>
<classLabel>t(5;17)(q35;q21)</classLabel>
<deletedAxiom>&apos;t(5;17)(q35;q21)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;NPM1 Gene&apos;</deletedAxiom>
<newAxiom>&apos;t(5;17)(q35;q21)&apos; SubClassOf (&apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;NPM1/RARA Short Fusion Gene&apos;) or (&apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;NPM1/RARA Long Fusion Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36364</classIRI>
<classLabel>t(11;17)(q13;q21)</classLabel>
<newAxiom>&apos;t(11;17)(q13;q21)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;NUMA1/RARA Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36387</classIRI>
<classLabel>t(12;15)(p13;q25)</classLabel>
<newAxiom>&apos;t(12;15)(p13;q25)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;ETV6/NTRK3 Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36377</classIRI>
<classLabel>t(3;12)(q27-28;q13-15)</classLabel>
<newAxiom>&apos;t(3;12)(q27-28;q13-15)&apos; SubClassOf (&apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;HMGA2/LPP Short Fusion Gene&apos;) or (&apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;HMGA2/LPP Long Fusion Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36394</classIRI>
<classLabel>t(9;15)(q22;q21)</classLabel>
<newAxiom>&apos;t(9;15)(q22;q21)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;TCF12/NR4A3 Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185471</classIRI>
<classLabel>Infant-Type Hemispheric Glioma</classLabel>
<deletedAxiom>&apos;Infant-Type Hemispheric Glioma&apos; EquivalentTo &apos;Malignant Brain Glioma&apos; and &apos;Malignant Cerebral Neoplasm&apos; and &apos;Malignant Childhood Central Nervous System Neoplasm&apos; and &apos;Childhood Supratentorial Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Increased Cellularity Present&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;High Grade&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Necrotic Change&apos;)</deletedAxiom>
<newAxiom>&apos;Infant-Type Hemispheric Glioma&apos; EquivalentTo &apos;Malignant Brain Glioma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Malignant Cerebral Neoplasm&apos; and &apos;Childhood Supratentorial Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Increased Cellularity Present&apos;) and (&apos;Disease_Is_Grade&apos; some &apos;High Grade&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Necrotic Change&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36563</classIRI>
<classLabel>t(1;3)(p36;q23-25)</classLabel>
<deletedAxiom>&apos;t(1;3)(p36;q23-25)&apos; SubClassOf &apos;Chromosome 1 Abnormality&apos;</deletedAxiom>
<deletedAxiom>&apos;t(1;3)(p36;q23-25)&apos; SubClassOf &apos;Rearrangement of 3q&apos;</deletedAxiom>
<newAxiom>&apos;t(1;3)(p36;q23-25)&apos; SubClassOf &apos;CAMTA1 Gene Rearrangement&apos;</newAxiom>
<newAxiom>&apos;t(1;3)(p36;q23-25)&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187410</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36520</classIRI>
<classLabel>t(17;22)(q22;q13)</classLabel>
<newAxiom>&apos;t(17;22)(q22;q13)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;COL1A1/PDGFB Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36606</classIRI>
<classLabel>t(3;21)(q26;q22)</classLabel>
<newAxiom>&apos;t(3;21)(q26;q22)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;RUNX1/MECOM Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C147027</classIRI>
<classLabel>Anti-DLL3/CD3 BiTE Antibody AMG 757</classLabel>
<deletedAxiom>&apos;Anti-DLL3/CD3 BiTE Antibody AMG 757&apos; SubClassOf &apos;Monoclonal Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Anti-DLL3/CD3 BiTE Antibody AMG 757&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95252</classIRI>
<classLabel>TET2 Gene</classLabel>
<newAxiom>&apos;TET2 Gene&apos; SubClassOf &apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187445</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C127194</classIRI>
<classLabel>Somatotroph/Lactotroph Adenoma</classLabel>
<deletedAxiom>&apos;Somatotroph/Lactotroph Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Acidophilic Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Growth Hormone and Prolactin-Producing Neoplastic Cells Present&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Giant Mitochondria Present&apos;)</deletedAxiom>
<newAxiom>&apos;Somatotroph/Lactotroph Adenoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187086 and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Acidophilic Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Growth Hormone and Prolactin-Producing Neoplastic Cells Present&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Giant Mitochondria Present&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6252</classIRI>
<classLabel>Childhood Brain Anaplastic Astrocytoma</classLabel>
<deletedAxiom>&apos;Childhood Brain Anaplastic Astrocytoma&apos; EquivalentTo &apos;Malignant Brain Glioma&apos; and &apos;Brain Astrocytoma&apos; and &apos;Childhood Anaplastic Astrocytoma&apos; and &apos;Childhood Brain Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Brain Anaplastic Astrocytoma&apos; EquivalentTo &apos;Malignant Brain Glioma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Brain Astrocytoma&apos; and &apos;Childhood Anaplastic Astrocytoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6207</classIRI>
<classLabel>Childhood Brain Germinoma</classLabel>
<deletedAxiom>&apos;Childhood Brain Germinoma&apos; EquivalentTo &apos;Childhood Central Nervous System Germinoma&apos; and &apos;Childhood Brain Germ Cell Tumor&apos; and &apos;Brain Germinoma&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Brain Germinoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Childhood Central Nervous System Germinoma&apos; and &apos;Childhood Brain Germ Cell Tumor&apos; and &apos;Brain Germinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17359</classIRI>
<classLabel>TP53 Gene</classLabel>
<deletedAxiom>&apos;TP53 Gene&apos; EquivalentTo &apos;Cell Cycle Gene&apos; and (&apos;Gene_Has_Abnormality&apos; some &apos;TP53 Gene Inactivation&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Ovarian High Grade Serous Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Proneural Glioblastoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Primary Peritoneal High Grade Serous Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Serous Tubal Intraepithelial Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Fallopian Tube High Grade Serous Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Schistosoma Hematobium-Related Bladder Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Penile Carcinoma In Situ&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Colorectal Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Li-Fraumeni Syndrome&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Gliosarcoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Type II Endometrial Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Secondary Glioblastoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Infiltrating Urothelial Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Esophageal Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Esophageal Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Laryngeal Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Vulvar Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Giant Cell Glioblastoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Oral Cavity Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Childhood Glioblastoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Porocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Bowen Disease of the Skin&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Ampulla of Vater Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Oropharyngeal Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Bowenoid Papulosis&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Cervical Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Adult Glioblastoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Breast Medullary Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Pancreatic Ductal Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Gallbladder Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Gastroesophageal Junction Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Anaplastic Astrocytoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;High Grade Pancreatic Intraepithelial Neoplasia&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Myelodysplastic Syndrome with Somatic Mutations&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;Aging&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;Positive Regulation of Apoptosis&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Hepatocellular Carcinoma&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Nasopharyngeal Carcinoma&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Thyroid Gland Carcinoma&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Osteosarcoma&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Adrenal Cortex Carcinoma&apos;)</deletedAxiom>
<newAxiom>&apos;TP53 Gene&apos; EquivalentTo &apos;Cell Cycle Gene&apos; and (&apos;Gene_Has_Abnormality&apos; some &apos;TP53 Gene Inactivation&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Ovarian High Grade Serous Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Proneural Glioblastoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Primary Peritoneal High Grade Serous Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Serous Tubal Intraepithelial Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Fallopian Tube High Grade Serous Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187447) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Schistosoma Hematobium-Related Bladder Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Penile Carcinoma In Situ&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Colorectal Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Li-Fraumeni Syndrome&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Gliosarcoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Type II Endometrial Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Secondary Glioblastoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Infiltrating Urothelial Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Esophageal Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Esophageal Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Laryngeal Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Vulvar Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Giant Cell Glioblastoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Oral Cavity Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Childhood Glioblastoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Porocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Bowen Disease of the Skin&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Ampulla of Vater Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Oropharyngeal Squamous Cell Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Bowenoid Papulosis&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Cervical Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Adult Glioblastoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Breast Medullary Carcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Pancreatic Ductal Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Gallbladder Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Gastroesophageal Junction Adenocarcinoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Anaplastic Astrocytoma&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;High Grade Pancreatic Intraepithelial Neoplasia&apos;) and (&apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some &apos;Myelodysplastic Syndrome with Somatic Mutations&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;Aging&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;DNA Repair&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;Positive Regulation of Apoptosis&apos;) and (&apos;Gene_Plays_Role_In_Process&apos; some &apos;Tumor Suppression&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Hepatocellular Carcinoma&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Nasopharyngeal Carcinoma&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Thyroid Gland Carcinoma&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Breast Carcinoma&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Osteosarcoma&apos;) and (&apos;Gene_Associated_With_Disease&apos; some &apos;Adrenal Cortex Carcinoma&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17310</classIRI>
<classLabel>Melatonin Receptor</classLabel>
<deletedAxiom>&apos;Melatonin Receptor&apos; SubClassOf &apos;G Protein-Coupled Receptor&apos;</deletedAxiom>
<newAxiom>&apos;Melatonin Receptor&apos; SubClassOf &apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;G Protein-Coupled Receptor&apos;</newAxiom>
<newAxiom>&apos;Melatonin Receptor&apos; SubClassOf &apos;Protein Family&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C81980</classIRI>
<classLabel>Beta-2 Microglobulin Measurement</classLabel>
<newAxiom>&apos;Beta-2 Microglobulin Measurement&apos; SubClassOf &apos;Protein or Enzyme Type Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17470</classIRI>
<classLabel>Telomerase</classLabel>
<deletedAxiom>&apos;Telomerase&apos; SubClassOf &apos;Protein or Riboprotein Complex&apos;</deletedAxiom>
<newAxiom>&apos;Telomerase&apos; SubClassOf &apos;Ribonucleoprotein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4009</classIRI>
<classLabel>Non-Functioning Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;Non-Functioning Pituitary Gland Neoplasm&apos; EquivalentTo &apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; and &apos;Non-Functioning Endocrine Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Absence of a Hormonal Syndrome&apos;)</deletedAxiom>
<newAxiom>&apos;Non-Functioning Pituitary Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17728</classIRI>
<classLabel>Ligand Binding Protein</classLabel>
<newAxiom>&apos;Ligand Binding Protein&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Ligand Binding Domain&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131362</classIRI>
<classLabel>CDKAL1 Gene</classLabel>
<newAxiom>&apos;CDKAL1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Post-Transcriptional Regulation&apos;</newAxiom>
<newAxiom>&apos;CDKAL1 Gene&apos; SubClassOf &apos;Translation Process Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131364</classIRI>
<classLabel>Threonylcarbamoyladenosine tRNA Methylthiotransferase</classLabel>
<newAxiom>&apos;Threonylcarbamoyladenosine tRNA Methylthiotransferase&apos; SubClassOf &apos;Translation Process Protein&apos;</newAxiom>
<newAxiom>&apos;Threonylcarbamoyladenosine tRNA Methylthiotransferase&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Post-Transcriptional Regulation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4536</classIRI>
<classLabel>Metastatic Pituitary Neuroendocrine Tumor</classLabel>
<deletedAxiom>&apos;Metastatic Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Metastatic Head and Neck Carcinoma&apos; and &apos;Metastatic Intracranial Malignant Neoplasm&apos; and &apos;Malignant Endocrine Neoplasm&apos; and &apos;Metastatic Adenocarcinoma&apos; and &apos;Malignant Pituitary Gland Neoplasm&apos; and &apos;Central Nervous System Carcinoma&apos; and &apos;Infrequent Neoplasm&apos; and &apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Adenohypophysial Cell&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 14q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 5&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 7p&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Unfavorable Clinical Outcome&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;HRAS Gene Mutation&apos;)</deletedAxiom>
<newAxiom>&apos;Metastatic Pituitary Neuroendocrine Tumor&apos; EquivalentTo &apos;Metastatic Head and Neck Carcinoma&apos; and &apos;Metastatic Neuroendocrine Carcinoma&apos; and &apos;Head and Neck Neuroendocrine Carcinoma&apos; and &apos;Metastatic Intracranial Malignant Neoplasm&apos; and &apos;Pituitary Gland Adenoma&apos; and &apos;Malignant Pituitary Gland Neoplasm&apos; and &apos;Central Nervous System Carcinoma&apos; and &apos;Infrequent Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Adenohypophysial Cell&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 14q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 5&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 7p&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Unfavorable Clinical Outcome&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;HRAS Gene Mutation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4348</classIRI>
<classLabel>Non-Functioning Pituitary Gland Adenoma</classLabel>
<deletedAxiom>&apos;Non-Functioning Pituitary Gland Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and &apos;Non-Functioning Pituitary Gland Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Non-Functioning Pituitary Gland Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and &apos;Non-Functioning Endocrine Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37249</classIRI>
<classLabel>t(2;22)(q33;q12)</classLabel>
<deletedAxiom>&apos;t(2;22)(q33;q12)&apos; SubClassOf &apos;Chromosomal Translocation&apos;</deletedAxiom>
<newAxiom>&apos;t(2;22)(q33;q12)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;EWSR1/CREB1 Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159727</classIRI>
<classLabel>Live with Others Due to Financial Difficulties</classLabel>
<deletedAxiom>&apos;Live with Others Due to Financial Difficulties&apos; SubClassOf &apos;Clinical or Research Assessment Question&apos;</deletedAxiom>
<newAxiom>&apos;Live with Others Due to Financial Difficulties&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159726</classIRI>
<classLabel>Struggle with Rent or Mortgage Due to Financial Difficulties</classLabel>
<newAxiom>&apos;Struggle with Rent or Mortgage Due to Financial Difficulties&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C184375</classIRI>
<classLabel>Anti-PD-L1/TGF-beta Bispecific Antibody Y101D</classLabel>
<deletedAxiom>&apos;Anti-PD-L1/TGF-beta Bispecific Antibody Y101D&apos; SubClassOf &apos;Antineoplastic Biological Agent&apos;</deletedAxiom>
<newAxiom>&apos;Anti-PD-L1/TGF-beta Bispecific Antibody Y101D&apos; SubClassOf &apos;Bispecific Antibody&apos;</newAxiom>
<newAxiom>&apos;Anti-PD-L1/TGF-beta Bispecific Antibody Y101D&apos; SubClassOf &apos;Anti-PD-L1 Monoclonal Antibody&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37887</classIRI>
<classLabel>t(9;12)(p24;p13)</classLabel>
<newAxiom>&apos;t(9;12)(p24;p13)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;ETV6/JAK2 Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112401</classIRI>
<classLabel>Pseudocowpox Virus</classLabel>
<deletedAxiom>&apos;Pseudocowpox Virus&apos; SubClassOf &apos;Poxvirus&apos;</deletedAxiom>
<newAxiom>&apos;Pseudocowpox Virus&apos; SubClassOf &apos;Parapoxvirus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112357</classIRI>
<classLabel>Molluscum Contagiosum Virus</classLabel>
<deletedAxiom>&apos;Molluscum Contagiosum Virus&apos; SubClassOf &apos;Poxvirus&apos;</deletedAxiom>
<newAxiom>&apos;Molluscum Contagiosum Virus&apos; SubClassOf &apos;Molluscipoxvirus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112356</classIRI>
<classLabel>Molluscipoxvirus</classLabel>
<deletedAxiom>&apos;Molluscipoxvirus&apos; SubClassOf &apos;Poxvirus&apos;</deletedAxiom>
<newAxiom>&apos;Molluscipoxvirus&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187440</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112367</classIRI>
<classLabel>Parapoxvirus</classLabel>
<deletedAxiom>&apos;Parapoxvirus&apos; SubClassOf &apos;Poxvirus&apos;</deletedAxiom>
<newAxiom>&apos;Parapoxvirus&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187440</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96524</classIRI>
<classLabel>Orthopoxvirus</classLabel>
<deletedAxiom>&apos;Orthopoxvirus&apos; SubClassOf &apos;Poxvirus&apos;</deletedAxiom>
<newAxiom>&apos;Orthopoxvirus&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187440</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112018</classIRI>
<classLabel>Myasthenia Class V</classLabel>
<deletedAxiom>&apos;Myasthenia Class V&apos; SubClassOf &apos;Myasthenia Classification System&apos;</deletedAxiom>
<newAxiom>&apos;Myasthenia Class V&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187352</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112017</classIRI>
<classLabel>Myasthenia Class IV</classLabel>
<deletedAxiom>&apos;Myasthenia Class IV&apos; SubClassOf &apos;Myasthenia Classification System&apos;</deletedAxiom>
<newAxiom>&apos;Myasthenia Class IV&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187352</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112014</classIRI>
<classLabel>Myasthenia Class I</classLabel>
<deletedAxiom>&apos;Myasthenia Class I&apos; SubClassOf &apos;Myasthenia Classification System&apos;</deletedAxiom>
<newAxiom>&apos;Myasthenia Class I&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187352</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112016</classIRI>
<classLabel>Myasthenia Class III</classLabel>
<deletedAxiom>&apos;Myasthenia Class III&apos; SubClassOf &apos;Myasthenia Classification System&apos;</deletedAxiom>
<newAxiom>&apos;Myasthenia Class III&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187352</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112015</classIRI>
<classLabel>Myasthenia Class II</classLabel>
<deletedAxiom>&apos;Myasthenia Class II&apos; SubClassOf &apos;Myasthenia Classification System&apos;</deletedAxiom>
<newAxiom>&apos;Myasthenia Class II&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187352</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126598</classIRI>
<classLabel>Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear Features</classLabel>
<deletedAxiom>&apos;Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear Features&apos; EquivalentTo &apos;Thyroid Gland Neoplasm&apos; and &apos;Encapsulated Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Thyroid Gland&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Ground Glass Nuclear Inclusion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Favorable Clinical Outcome&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Follicular Cell Differentiation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Follicular Structures Present&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Pseudoinclusion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Clearing&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Grooves&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Questionable Invasive Lesion&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Papillary Pattern&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Invasive Lesion&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;KRAS Gene Mutation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;NRAS Gene Mutation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;HRAS Gene Mutation&apos;)</deletedAxiom>
<newAxiom>&apos;Thyroid Gland Noninvasive Follicular Neoplasm with Papillary-Like Nuclear Features&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187273 and &apos;Encapsulated Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Thyroid Gland&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Ground Glass Nuclear Inclusion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Favorable Clinical Outcome&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Follicular Cell Differentiation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Follicular Structures Present&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Pseudoinclusion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Clearing&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Grooves&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Questionable Invasive Lesion&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Papillary Pattern&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Invasive Lesion&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;KRAS Gene Mutation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;NRAS Gene Mutation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;HRAS Gene Mutation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126111</classIRI>
<classLabel>Infant Acute Biphenotypic Leukemia</classLabel>
<deletedAxiom>&apos;Infant Acute Biphenotypic Leukemia&apos; EquivalentTo &apos;Infant Leukemia&apos; and &apos;Acute Biphenotypic Leukemia&apos;</deletedAxiom>
<newAxiom>&apos;Infant Acute Biphenotypic Leukemia&apos; EquivalentTo &apos;Infant Leukemia&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187056 and &apos;Acute Biphenotypic Leukemia&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126110</classIRI>
<classLabel>Infant Acute Undifferentiated Leukemia</classLabel>
<deletedAxiom>&apos;Infant Acute Undifferentiated Leukemia&apos; EquivalentTo &apos;Infant Leukemia&apos; and &apos;Acute Undifferentiated Leukemia&apos;</deletedAxiom>
<newAxiom>&apos;Infant Acute Undifferentiated Leukemia&apos; EquivalentTo &apos;Infant Leukemia&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187056 and &apos;Acute Undifferentiated Leukemia&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43541</classIRI>
<classLabel>Pituitary Gland Microadenoma</classLabel>
<deletedAxiom>&apos;Pituitary Gland Microadenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Lesion with Diameter of 10 mm or Less&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;MEN1 Gene Inactivation&apos;)</deletedAxiom>
<newAxiom>&apos;Pituitary Gland Microadenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Lesion with Diameter of 10 mm or Less&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43542</classIRI>
<classLabel>Pituitary Gland Macroadenoma</classLabel>
<deletedAxiom>&apos;Pituitary Gland Macroadenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Lesion with Diameter Greater than 10 mm&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;MEN1 Gene Inactivation&apos;)</deletedAxiom>
<newAxiom>&apos;Pituitary Gland Macroadenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Lesion with Diameter Greater than 10 mm&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168760</classIRI>
<classLabel>t(11;17)(q23;q12-21)</classLabel>
<deletedAxiom>&apos;t(11;17)(q23;q12-21)&apos; SubClassOf &apos;Chromosome 17 Abnormality&apos;</deletedAxiom>
<newAxiom>&apos;t(11;17)(q23;q12-21)&apos; SubClassOf &apos;MLLT6 Gene Rearrangement&apos;</newAxiom>
<newAxiom>&apos;t(11;17)(q23;q12-21)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;KMT2A/MLLT6 Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77127</classIRI>
<classLabel>Neuronal Acetylcholine Receptor Subunit Alpha-5</classLabel>
<deletedAxiom>&apos;Neuronal Acetylcholine Receptor Subunit Alpha-5&apos; EquivalentTo &apos;Ion Channel Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Gated Ion Channel&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Postsynaptic Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRNA5 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Neuronal Acetylcholine Receptor Subunit Alpha-5&apos; EquivalentTo &apos;Ion Channel Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Gated Ion Channel&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Postsynaptic Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187222) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRNA5 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77125</classIRI>
<classLabel>Neuronal Acetylcholine Receptor Subunit Alpha-3</classLabel>
<deletedAxiom>&apos;Neuronal Acetylcholine Receptor Subunit Alpha-3&apos; EquivalentTo &apos;Ion Channel Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Gated Ion Channel&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Postsynaptic Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRNA3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Neuronal Acetylcholine Receptor Subunit Alpha-3&apos; EquivalentTo &apos;Ion Channel Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Gated Ion Channel&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Postsynaptic Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187222) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRNA3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77126</classIRI>
<classLabel>Neuronal Acetylcholine Receptor Subunit Beta-4</classLabel>
<deletedAxiom>&apos;Neuronal Acetylcholine Receptor Subunit Beta-4&apos; EquivalentTo &apos;Ion Channel Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Gated Ion Channel&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Postsynaptic Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRNB4 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Neuronal Acetylcholine Receptor Subunit Beta-4&apos; EquivalentTo &apos;Ion Channel Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neuroactive Ligand-Receptor Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Gated Ion Channel&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Postsynaptic Membrane&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Lung Carcinoma&apos;) and (&apos;Gene_Product_Is_Physical_Part_Of&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187222) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Cell Surface Receptor&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Neuronal Transmission&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CHRNB4 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154245</classIRI>
<classLabel>Free of Money Problems</classLabel>
<deletedAxiom>&apos;Free of Money Problems&apos; SubClassOf &apos;Clinical or Research Assessment Question&apos;</deletedAxiom>
<newAxiom>&apos;Free of Money Problems&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7952</classIRI>
<classLabel>Childhood Burkitt Leukemia</classLabel>
<deletedAxiom>&apos;Childhood Burkitt Leukemia&apos; EquivalentTo &apos;Childhood Leukemia&apos; and &apos;Burkitt Leukemia&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Burkitt Leukemia&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187056 and &apos;Burkitt Leukemia&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7915</classIRI>
<classLabel>TSH-Producing Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;TSH-Producing Pituitary Gland Neoplasm&apos; EquivalentTo &apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Thyrotroph Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Thyrotroph Cell&apos;)</deletedAxiom>
<newAxiom>&apos;TSH-Producing Pituitary Gland Neoplasm&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187086 and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Thyrotroph Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Thyrotroph Cell&apos;) and (&apos;Disease_Excludes_Normal_Cell_Origin&apos; some &apos;Lactotroph Cell&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Neoplastic Somatotroph Cell with Abundant Secretory Granules&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Growth Hormone and Prolactin-Producing Neoplastic Cells Present&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7911</classIRI>
<classLabel>Growth Hormone-Producing Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;Growth Hormone-Producing Pituitary Gland Neoplasm&apos; EquivalentTo &apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Somatotroph Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Somatotroph Cell&apos;)</deletedAxiom>
<newAxiom>&apos;Growth Hormone-Producing Pituitary Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7910</classIRI>
<classLabel>Prolactin-Producing Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;Prolactin-Producing Pituitary Gland Neoplasm&apos; EquivalentTo &apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Lactotroph Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Lactotroph Cell&apos;)</deletedAxiom>
<newAxiom>&apos;Prolactin-Producing Pituitary Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7909</classIRI>
<classLabel>ACTH-Producing Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;ACTH-Producing Pituitary Gland Neoplasm&apos; EquivalentTo &apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Glandular Epithelial Tissue&apos;) and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Corticotroph Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Corticotroph Cell&apos;)</deletedAxiom>
<newAxiom>&apos;ACTH-Producing Pituitary Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7861</classIRI>
<classLabel>Localized Digestive System Neuroendocrine Tumor G1</classLabel>
<deletedAxiom>&apos;Localized Digestive System Neuroendocrine Tumor G1&apos; EquivalentTo &apos;Digestive System Neuroendocrine Tumor G1&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Localized Disease&apos;)</deletedAxiom>
<newAxiom>&apos;Localized Digestive System Neuroendocrine Tumor G1&apos; EquivalentTo &apos;Digestive System Neuroendocrine Tumor G1&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Localized Disease&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Metastatic Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C120449</classIRI>
<classLabel>Congenital Isolated Thyroid Stimulating Hormone Deficiency</classLabel>
<deletedAxiom>&apos;Congenital Isolated Thyroid Stimulating Hormone Deficiency&apos; SubClassOf &apos;Abnormal Blood Chemistry and Hematology Test Result&apos;</deletedAxiom>
<newAxiom>&apos;Congenital Isolated Thyroid Stimulating Hormone Deficiency&apos; SubClassOf &apos;Hormone Imbalance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173973</classIRI>
<classLabel>Sacituzumab Govitecan Regimen</classLabel>
<newAxiom>&apos;Sacituzumab Govitecan Regimen&apos; SubClassOf &apos;Regimen Used to Treat Bladder Carcinoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38967</classIRI>
<classLabel>Mucin-1</classLabel>
<deletedAxiom>&apos;Mucin-1&apos; EquivalentTo &apos;Mucin&apos; and &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MUC1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Mucin-1&apos; EquivalentTo &apos;Mucin&apos; and &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Plasma Membrane&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;MUC1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173540</classIRI>
<classLabel>Anti-CTLA-4 Monoclonal Antibody HBM4003</classLabel>
<deletedAxiom>&apos;Anti-CTLA-4 Monoclonal Antibody HBM4003&apos; SubClassOf &apos;Bispecific Monoclonal Antibody&apos;</deletedAxiom>
<deletedAxiom>&apos;Anti-CTLA-4 Monoclonal Antibody HBM4003&apos; SubClassOf &apos;Anti-PD1 Monoclonal Antibody&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97720</classIRI>
<classLabel>Myomegalin</classLabel>
<deletedAxiom>&apos;Myomegalin&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centrosome&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDE4DIP Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Myomegalin&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Centrosome&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Heart&apos;) and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Skeletal Muscle Tissue&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Coiled-Coil Domain&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Protein Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;PDE4DIP Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101559</classIRI>
<classLabel>SGK1 Gene</classLabel>
<newAxiom>&apos;SGK1 Gene&apos; SubClassOf &apos;Gene_Involved_In_Pathogenesis_Of_Disease&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187445</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8059</classIRI>
<classLabel>Recurrent Childhood Hodgkin Lymphoma</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Hodgkin Lymphoma&apos; EquivalentTo &apos;Recurrent Childhood Malignant Neoplasm&apos; and &apos;Recurrent Hodgkin Lymphoma&apos; and &apos;Childhood Hodgkin Lymphoma&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Hodgkin Lymphoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187196 and &apos;Recurrent Hodgkin Lymphoma&apos; and &apos;Childhood Hodgkin Lymphoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8011</classIRI>
<classLabel>Thyrotroph Adenoma</classLabel>
<deletedAxiom>&apos;Thyrotroph Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and &apos;TSH-Producing Pituitary Gland Neoplasm&apos; and (&apos;Disease_Excludes_Normal_Cell_Origin&apos; some &apos;Lactotroph Cell&apos;) and (&apos;Disease_Excludes_Abnormal_Cell&apos; some &apos;Neoplastic Somatotroph Cell with Abundant Secretory Granules&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Growth Hormone and Prolactin-Producing Neoplastic Cells Present&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Giant Mitochondria Present&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;MEN1 Gene Mutation&apos;)</deletedAxiom>
<newAxiom>&apos;Thyrotroph Adenoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101097</classIRI>
<classLabel>Cyclin-Dependent Kinase 12</classLabel>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 12&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;</deletedAxiom>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 12&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK12 Gene&apos;</deletedAxiom>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 12&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Splicing&apos;</deletedAxiom>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 12&apos; SubClassOf &apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;</deletedAxiom>
<deletedAxiom>&apos;Cyclin-Dependent Kinase 12&apos; SubClassOf &apos;Cyclin-Dependent Kinase&apos;</deletedAxiom>
<newAxiom>&apos;Cyclin-Dependent Kinase 12&apos; EquivalentTo &apos;Cyclin-Dependent Kinase&apos; and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleus&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Splicing&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;CDK12 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115369</classIRI>
<classLabel>Recurrent Childhood Non-Hodgkin Lymphoma</classLabel>
<deletedAxiom>&apos;Recurrent Childhood Non-Hodgkin Lymphoma&apos; EquivalentTo &apos;Recurrent Childhood Malignant Neoplasm&apos; and &apos;Childhood Non-Hodgkin Lymphoma&apos; and &apos;Recurrent Non-Hodgkin Lymphoma&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Childhood Non-Hodgkin Lymphoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187196 and &apos;Childhood Non-Hodgkin Lymphoma&apos; and &apos;Recurrent Non-Hodgkin Lymphoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C115458</classIRI>
<classLabel>Refractory Childhood Hodgkin Lymphoma</classLabel>
<deletedAxiom>&apos;Refractory Childhood Hodgkin Lymphoma&apos; EquivalentTo &apos;Refractory Childhood Malignant Neoplasm&apos; and &apos;Childhood Hodgkin Lymphoma&apos; and &apos;Refractory Hodgkin Lymphoma&apos;</deletedAxiom>
<newAxiom>&apos;Refractory Childhood Hodgkin Lymphoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187197 and &apos;Childhood Hodgkin Lymphoma&apos; and &apos;Refractory Hodgkin Lymphoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8388</classIRI>
<classLabel>Functioning Pituitary Gland Adenoma</classLabel>
<deletedAxiom>&apos;Functioning Pituitary Gland Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and &apos;Functioning Pituitary Gland Neoplasm&apos; and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;MEN1 Gene Inactivation&apos;)</deletedAxiom>
<newAxiom>&apos;Functioning Pituitary Gland Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and &apos;Functioning Endocrine Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154827</classIRI>
<classLabel>Rotavirus Antigen Measurement</classLabel>
<deletedAxiom>&apos;Rotavirus Antigen Measurement&apos; SubClassOf &apos;Rotavirus RNA Measurement&apos;</deletedAxiom>
<newAxiom>&apos;Rotavirus Antigen Measurement&apos; SubClassOf &apos;Rotavirus Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154519</classIRI>
<classLabel>Pituitary Gland Double Adenomas</classLabel>
<deletedAxiom>&apos;Pituitary Gland Double Adenomas&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Two Separate Tumor Masses Present in the Same Organ&apos;)</deletedAxiom>
<newAxiom>&apos;Pituitary Gland Double Adenomas&apos; EquivalentTo &apos;Pituitary Gland Multiple Adenomas&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Two Separate Tumor Masses Present in the Same Organ&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C8997</classIRI>
<classLabel>Blastoma</classLabel>
<deletedAxiom>&apos;Blastoma&apos; EquivalentTo &apos;Embryonal Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Blastemal Cell&apos;) and (&apos;Disease_Has_Molecular_Abnormality&apos; some &apos;DICER1 Gene Mutation&apos;) and (&apos;Disease_Has_Associated_Disease&apos; some &apos;DICER1 Syndrome&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;DICER1 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Blastoma&apos; EquivalentTo &apos;Embryonal Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Malignant Blastemal Cell&apos;) and (&apos;Disease_Has_Molecular_Abnormality&apos; some &apos;DICER1 Gene Mutation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;DICER1 Gene Alteration Positive&apos;) and (&apos;Disease_Has_Associated_Disease&apos; some &apos;DICER1 Syndrome&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;DICER1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C120909</classIRI>
<classLabel>Spermatocele</classLabel>
<deletedAxiom>&apos;Spermatocele&apos; SubClassOf &apos;Reproductive System Finding&apos;</deletedAxiom>
<newAxiom>&apos;Spermatocele&apos; SubClassOf &apos;Male Reproductive System Finding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6846</classIRI>
<classLabel>Thyroid Gland Hyalinizing Trabecular Tumor</classLabel>
<deletedAxiom>&apos;Thyroid Gland Hyalinizing Trabecular Tumor&apos; EquivalentTo &apos;Thyroid Gland Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Thyroid Gland&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Thyroid Gland Follicle&apos;) and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Thyroid Gland Follicular Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Thyroid Gland Follicular Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Cold Nodule&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Trabecular Pattern&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Hyalinized Stroma Formation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Thyroglobulin-Positive Neoplastic Cells Present&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Psammoma Body Formation&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Radiation Toxicity&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Indolent Clinical Course&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Encapsulated Mass&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Thyroid Gland Papillary Carcinoma&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;RET/PTC Rearrangement&apos;)</deletedAxiom>
<newAxiom>&apos;Thyroid Gland Hyalinizing Trabecular Tumor&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187273 and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Thyroid Gland&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Thyroid Gland Follicle&apos;) and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Thyroid Gland Follicular Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Thyroid Gland Follicular Cell&apos;) and (&apos;Disease_Has_Cytogenetic_Abnormality&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187277) and (&apos;Disease_Has_Finding&apos; some &apos;Cold Nodule&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Trabecular Pattern&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Hyalinized Stroma Formation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Thyroglobulin-Positive Neoplastic Cells Present&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187432) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187433) and (&apos;Disease_May_Have_Finding&apos; some &apos;Psammoma Body Formation&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Radiation Toxicity&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Indolent Clinical Course&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Encapsulated Mass&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Well-Circumscribed Lesion&apos;) and (&apos;Disease_May_Have_Associated_Disease&apos; some &apos;Thyroid Gland Papillary Carcinoma&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187434) and (&apos;Disease_Mapped_To_Gene&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187436)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6772</classIRI>
<classLabel>Childhood Supratentorial Embryonal Tumor with Multilayered Rosettes, C19MC-Altered</classLabel>
<deletedAxiom>&apos;Childhood Supratentorial Embryonal Tumor with Multilayered Rosettes, C19MC-Altered&apos; EquivalentTo &apos;Childhood Embryonal Tumor with Multilayered Rosettes, C19MC-Altered&apos; and &apos;Primary Brain Neoplasm&apos; and &apos;Malignant Supratentorial Neoplasm&apos; and &apos;Childhood Supratentorial Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Supratentorial Embryonal Tumor with Multilayered Rosettes, C19MC-Altered&apos; EquivalentTo &apos;Childhood Embryonal Tumor with Multilayered Rosettes, C19MC-Altered&apos; and &apos;Primary Brain Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Malignant Supratentorial Neoplasm&apos; and &apos;Childhood Supratentorial Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C6773</classIRI>
<classLabel>Childhood Infratentorial Embryonal Tumor with Multilayered Rosettes, C19MC-Altered</classLabel>
<deletedAxiom>&apos;Childhood Infratentorial Embryonal Tumor with Multilayered Rosettes, C19MC-Altered&apos; EquivalentTo &apos;Childhood Embryonal Tumor with Multilayered Rosettes, C19MC-Altered&apos; and &apos;Primary Brain Neoplasm&apos; and &apos;Malignant Infratentorial Neoplasm&apos; and &apos;Childhood Infratentorial Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Infratentorial Brain&apos;)</deletedAxiom>
<newAxiom>&apos;Childhood Infratentorial Embryonal Tumor with Multilayered Rosettes, C19MC-Altered&apos; EquivalentTo &apos;Childhood Embryonal Tumor with Multilayered Rosettes, C19MC-Altered&apos; and &apos;Primary Brain Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Malignant Infratentorial Neoplasm&apos; and &apos;Childhood Infratentorial Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Infratentorial Brain&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98098</classIRI>
<classLabel>Uncharacterized Protein C15orf65</classLabel>
<deletedAxiom>&apos;Uncharacterized Protein C15orf65&apos; SubClassOf &apos;Regulatory Protein&apos;</deletedAxiom>
<newAxiom>&apos;Uncharacterized Protein C15orf65&apos; SubClassOf &apos;Microtubule Associated Protein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98096</classIRI>
<classLabel>C15orf65 Gene</classLabel>
<deletedAxiom>&apos;C15orf65 Gene&apos; SubClassOf &apos;Regulatory Gene&apos;</deletedAxiom>
<newAxiom>&apos;C15orf65 Gene&apos; SubClassOf &apos;Cytoskeletal Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C147901</classIRI>
<classLabel>Childhood Brain Glioblastoma</classLabel>
<deletedAxiom>&apos;Childhood Brain Glioblastoma&apos; EquivalentTo &apos;Brain Glioblastoma&apos; and &apos;Childhood Glioblastoma&apos; and &apos;Childhood Brain Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Brain Glioblastoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Brain Glioblastoma&apos; and &apos;Childhood Glioblastoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64806</classIRI>
<classLabel>Serum VLDL Cholesterol Measurement</classLabel>
<deletedAxiom>&apos;Serum VLDL Cholesterol Measurement&apos; SubClassOf &apos;Lipid Measurement&apos;</deletedAxiom>
<newAxiom>&apos;Serum VLDL Cholesterol Measurement&apos; SubClassOf &apos;Very Low Density Lipoprotein Cholesterol Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172900</classIRI>
<classLabel>Worry that Breast Cancer Recurrence Would Cause Financial Problems</classLabel>
<newAxiom>&apos;Worry that Breast Cancer Recurrence Would Cause Financial Problems&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98381</classIRI>
<classLabel>KRAS NM_004985.3:c.34_35delGGinsCT</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.34_35delGGinsCT&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98385</classIRI>
<classLabel>KRAS NM_004985.3:c.34_35delGGinsAA</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.34_35delGGinsAA&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98379</classIRI>
<classLabel>KRAS NM_004985.3:c.34_35delGGinsAT</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.34_35delGGinsAT&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98376</classIRI>
<classLabel>KRAS NM_004985.3:c.34_35delGGinsTT</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.34_35delGGinsTT&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98373</classIRI>
<classLabel>KRAS NM_004985.3:c.35_36delGTinsAG</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.35_36delGTinsAG&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98374</classIRI>
<classLabel>KRAS NM_004985.3:c.35_36delGTinsAA</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.35_36delGTinsAA&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98371</classIRI>
<classLabel>KRAS NM_004985.3:c.35_36delGTinsAC</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.35_36delGTinsAC&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98368</classIRI>
<classLabel>KRAS NM_004985.3:c.34_36delGGTinsTGC</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.34_36delGGTinsTGC&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98360</classIRI>
<classLabel>ERBB2 NM_004448.2:c.2325_2326ins12</classLabel>
<newAxiom>&apos;ERBB2 NM_004448.2:c.2325_2326ins12&apos; SubClassOf &apos;Activating ERBB2 Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98361</classIRI>
<classLabel>ERBB2 NM_004448.2:c.2324_2325ins12</classLabel>
<newAxiom>&apos;ERBB2 NM_004448.2:c.2324_2325ins12&apos; SubClassOf &apos;Activating ERBB2 Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98397</classIRI>
<classLabel>KRAS NM_004985.3:c.34_35delGGinsTA</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.34_35delGGinsTA&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98395</classIRI>
<classLabel>KRAS NM_004985.3:c.34_36delGGTinsTGG</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.34_36delGGTinsTGG&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98393</classIRI>
<classLabel>KRAS NM_004985.3:c.35_36delGTinsTC</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.35_36delGTinsTC&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98421</classIRI>
<classLabel>KRAS NM_004985.3:c.38_39delGCinsTT</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.38_39delGCinsTT&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98422</classIRI>
<classLabel>KRAS NM_004985.3:c.38_39delGCinsTG</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.38_39delGCinsTG&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98416</classIRI>
<classLabel>KRAS NM_004985.3:c.37_39delGGCinsCGT</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.37_39delGGCinsCGT&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98413</classIRI>
<classLabel>KRAS NM_004985.3:c.37_38delGGinsAA</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.37_38delGGinsAA&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98407</classIRI>
<classLabel>KRAS NM_004985.3:c.38_39delGCinsAG</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.38_39delGCinsAG&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98408</classIRI>
<classLabel>KRAS NM_004985.3:c.38_39delGCinsAA</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.38_39delGCinsAA&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98405</classIRI>
<classLabel>KRAS NM_004985.3:c.38_39delGCinsAT</classLabel>
<newAxiom>&apos;KRAS NM_004985.3:c.38_39delGCinsAT&apos; SubClassOf &apos;Non-Synonymous KRAS Gene Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172451</classIRI>
<classLabel>Generalized Anxiety Disorder - 7 Version 2 - Analysis</classLabel>
<deletedAxiom>&apos;Generalized Anxiety Disorder - 7 Version 2 - Analysis&apos; SubClassOf &apos;GAD-7 Questionnaire Question&apos;</deletedAxiom>
<newAxiom>&apos;Generalized Anxiety Disorder - 7 Version 2 - Analysis&apos; SubClassOf &apos;GAD-7 Version 2 Questionnaire Question&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114969</classIRI>
<classLabel>Childhood Gliomatosis Cerebri</classLabel>
<deletedAxiom>&apos;Childhood Gliomatosis Cerebri&apos; EquivalentTo &apos;Gliomatosis Cerebri&apos; and &apos;Malignant Childhood Central Nervous System Neoplasm&apos; and &apos;Childhood Brain Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Gliomatosis Cerebri&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Gliomatosis Cerebri&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84404</classIRI>
<classLabel>RNA-Induced Silencing Complex</classLabel>
<deletedAxiom>&apos;RNA-Induced Silencing Complex&apos; SubClassOf &apos;Protein or Riboprotein Complex&apos;</deletedAxiom>
<newAxiom>&apos;RNA-Induced Silencing Complex&apos; SubClassOf &apos;Ribonucleoprotein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C100461</classIRI>
<classLabel>Alpha-1 Microglobulin Measurement</classLabel>
<newAxiom>&apos;Alpha-1 Microglobulin Measurement&apos; SubClassOf &apos;Protein or Enzyme Type Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114812</classIRI>
<classLabel>Childhood Pineoblastoma</classLabel>
<deletedAxiom>&apos;Childhood Pineoblastoma&apos; EquivalentTo &apos;Childhood Central Nervous System Embryonal Tumor&apos; and &apos;Childhood Pineal Parenchymal Cell Neoplasm&apos; and &apos;Pineoblastoma&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Pineoblastoma&apos; EquivalentTo &apos;Childhood Central Nervous System Embryonal Tumor&apos; and &apos;Childhood Pineal Parenchymal Cell Neoplasm&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Pineoblastoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114774</classIRI>
<classLabel>Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified</classLabel>
<deletedAxiom>&apos;Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified&apos; EquivalentTo &apos;Childhood Supratentorial Neoplasm&apos; and &apos;Childhood Central Nervous System Embryonal Tumor, Not Otherwise Specified&apos; and &apos;Supratentorial Embryonal Tumor, Not Otherwise Specified&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Childhood Supratentorial Neoplasm&apos; and &apos;Childhood Central Nervous System Embryonal Tumor, Not Otherwise Specified&apos; and &apos;Supratentorial Embryonal Tumor, Not Otherwise Specified&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114775</classIRI>
<classLabel>Childhood Central Nervous System Neuroblastoma</classLabel>
<deletedAxiom>&apos;Childhood Central Nervous System Neuroblastoma&apos; EquivalentTo &apos;Childhood Central Nervous System Embryonal Tumor&apos; and &apos;Childhood Neuroblastoma&apos; and &apos;Central Nervous System Neuroblastoma&apos; and &apos;Childhood Supratentorial Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Childhood Central Nervous System Neuroblastoma&apos; EquivalentTo &apos;Childhood Central Nervous System Embryonal Tumor&apos; and &apos;Childhood Neuroblastoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207 and &apos;Central Nervous System Neuroblastoma&apos; and &apos;Childhood Supratentorial Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45717</classIRI>
<classLabel>t(15;19)(q13;p13.1)</classLabel>
<newAxiom>&apos;t(15;19)(q13;p13.1)&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;BRD4/NUTM1 Fusion Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79093</classIRI>
<classLabel>Excision Repair Cross-Complementing 1 Messenger RNA Expression Measurement</classLabel>
<deletedAxiom>&apos;Excision Repair Cross-Complementing 1 Messenger RNA Expression Measurement&apos; SubClassOf &apos;RNA Analysis&apos;</deletedAxiom>
<newAxiom>&apos;Excision Repair Cross-Complementing 1 Messenger RNA Expression Measurement&apos; SubClassOf &apos;Ribonucleic Acid Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79098</classIRI>
<classLabel>MYCN Messenger RNA Expression Measurement</classLabel>
<deletedAxiom>&apos;MYCN Messenger RNA Expression Measurement&apos; SubClassOf &apos;RNA Analysis&apos;</deletedAxiom>
<newAxiom>&apos;MYCN Messenger RNA Expression Measurement&apos; SubClassOf &apos;Ribonucleic Acid Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79096</classIRI>
<classLabel>Ribonucleotide Reductase Messenger RNA Expression Measurement</classLabel>
<deletedAxiom>&apos;Ribonucleotide Reductase Messenger RNA Expression Measurement&apos; SubClassOf &apos;RNA Analysis&apos;</deletedAxiom>
<newAxiom>&apos;Ribonucleotide Reductase Messenger RNA Expression Measurement&apos; SubClassOf &apos;Ribonucleic Acid Measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45837</classIRI>
<classLabel>Non-Functioning Pancreatic Neuroendocrine Tumor</classLabel>
<deletedAxiom>&apos;Non-Functioning Pancreatic Neuroendocrine Tumor&apos; EquivalentTo &apos;Pancreatic Neuroendocrine Tumor&apos; and &apos;Non-Functioning Endocrine Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Absence of a Hormonal Syndrome&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 6q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 4&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Indolent Clinical Course&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Presence of a Hormonal Syndrome&apos;)</deletedAxiom>
<newAxiom>&apos;Non-Functioning Pancreatic Neuroendocrine Tumor&apos; EquivalentTo &apos;Pancreatic Neuroendocrine Tumor&apos; and &apos;Non-Functioning Endocrine Neoplasm&apos; and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 6q&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 4&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Indolent Clinical Course&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7047</classIRI>
<classLabel>Functioning Pituitary Gland Neoplasm</classLabel>
<deletedAxiom>&apos;Functioning Pituitary Gland Neoplasm&apos; EquivalentTo &apos;Anterior Pituitary Gland Endocrine Neoplasm&apos; and &apos;Functioning Endocrine Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Presence of a Hormonal Syndrome&apos;)</deletedAxiom>
<newAxiom>&apos;Functioning Pituitary Gland Neoplasm&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45840</classIRI>
<classLabel>Functioning Pancreatic Neuroendocrine Tumor</classLabel>
<deletedAxiom>&apos;Functioning Pancreatic Neuroendocrine Tumor&apos; EquivalentTo &apos;Pancreatic Neuroendocrine Tumor&apos; and &apos;Functioning Endocrine Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Presence of a Hormonal Syndrome&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Absence of a Hormonal Syndrome&apos;)</deletedAxiom>
<newAxiom>&apos;Functioning Pancreatic Neuroendocrine Tumor&apos; EquivalentTo &apos;Pancreatic Neuroendocrine Tumor&apos; and &apos;Functioning Endocrine Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7017</classIRI>
<classLabel>Granular Cell Tumor of the Sellar Region</classLabel>
<deletedAxiom>&apos;Granular Cell Tumor of the Sellar Region&apos; EquivalentTo &apos;Granular Cell Tumor&apos; and &apos;Posterior Pituitary Gland Neoplasm&apos; and (&apos;Disease_May_Have_Finding&apos; some &apos;Slow Growing Mass&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Mitotic Activity&apos;)</deletedAxiom>
<newAxiom>&apos;Granular Cell Tumor of the Sellar Region&apos; EquivalentTo &apos;Granular Cell Tumor&apos; and &apos;Posterior Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Slow Growing Mass&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Mitotic Activity&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45935</classIRI>
<classLabel>Pituitary Gland Oncocytic Adenoma</classLabel>
<deletedAxiom>&apos;Pituitary Gland Oncocytic Adenoma&apos; EquivalentTo &apos;Oncocytic Adenoma&apos; and &apos;Null Cell Pituitary Gland Adenoma&apos;</deletedAxiom>
<newAxiom>&apos;Pituitary Gland Oncocytic Adenoma&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45929</classIRI>
<classLabel>Acidophil Stem Cell Pituitary Gland Adenoma</classLabel>
<deletedAxiom>&apos;Acidophil Stem Cell Pituitary Gland Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Acidophilic Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Misplaced Exocytosis Present&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Concentric Aggregates of Intermediate Filaments Present&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Giant Mitochondria Present&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Growth Hormone and Prolactin-Producing Neoplastic Cells Present&apos;)</deletedAxiom>
<newAxiom>&apos;Acidophil Stem Cell Pituitary Gland Adenoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187086 and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Acidophilic Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Misplaced Exocytosis Present&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Concentric Aggregates of Intermediate Filaments Present&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Giant Mitochondria Present&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Growth Hormone and Prolactin-Producing Neoplastic Cells Present&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45924</classIRI>
<classLabel>Null Cell Pituitary Gland Adenoma</classLabel>
<deletedAxiom>&apos;Null Cell Pituitary Gland Adenoma&apos; EquivalentTo &apos;Non-Functioning Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Endocrine Null Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;No Evidence of Hormonal Immunoreactivity Present&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Slow Growing Mass&apos;)</deletedAxiom>
<newAxiom>&apos;Null Cell Pituitary Gland Adenoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187096 and &apos;Non-Functioning Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Endocrine Null Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;No Evidence of Hormonal Immunoreactivity Present&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Slow Growing Mass&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45917</classIRI>
<classLabel>Pituitary Gland Gangliocytoma</classLabel>
<deletedAxiom>&apos;Pituitary Gland Gangliocytoma&apos; EquivalentTo &apos;Pituitary Gland Neoplasm&apos; and &apos;Gangliocytoma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Pituitary Gland&apos;)</deletedAxiom>
<newAxiom>&apos;Pituitary Gland Gangliocytoma&apos; EquivalentTo &apos;Sellar Region Neoplasm&apos; and &apos;Gangliocytoma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Sellar Region&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45915</classIRI>
<classLabel>Gonadotroph Adenoma</classLabel>
<deletedAxiom>&apos;Gonadotroph Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Gonadotroph Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Gonadotroph Cell&apos;)</deletedAxiom>
<newAxiom>&apos;Gonadotroph Adenoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187088 and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Gonadotroph Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Gonadotroph Cell&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45916</classIRI>
<classLabel>Plurihormonal Pituitary Gland Adenoma</classLabel>
<deletedAxiom>&apos;Plurihormonal Pituitary Gland Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Multihormonal Immunoreactivity Present&apos;)</deletedAxiom>
<newAxiom>&apos;Plurihormonal Pituitary Gland Adenoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187096 and (&apos;Disease_Has_Finding&apos; some &apos;Multihormonal Immunoreactivity Present&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7461</classIRI>
<classLabel>Somatotroph Adenoma</classLabel>
<deletedAxiom>&apos;Somatotroph Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and &apos;Growth Hormone-Producing Pituitary Gland Neoplasm&apos; and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 19&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 22&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 9&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 17&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 5&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 11&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 1&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 18&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 2&apos;) and (&apos;Disease_Excludes_Normal_Cell_Origin&apos; some &apos;Lactotroph Cell&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Growth Hormone and Prolactin-Producing Neoplastic Cells Present&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;GNAS Gene&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;CDKN2A Gene Inactivation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;GNAS Gene Mutation&apos;)</deletedAxiom>
<newAxiom>&apos;Somatotroph Adenoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187086 and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Somatotroph Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Somatotroph Cell&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 19&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 22&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 9&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 17&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Gain of Chromosome 5&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 11&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 1&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 18&apos;) and (&apos;Disease_May_Have_Cytogenetic_Abnormality&apos; some &apos;Loss of Chromosome 2&apos;) and (&apos;Disease_Excludes_Normal_Cell_Origin&apos; some &apos;Lactotroph Cell&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Growth Hormone and Prolactin-Producing Neoplastic Cells Present&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;GNAS Gene&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;CDKN2A Gene Inactivation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;GNAS Gene Mutation&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7462</classIRI>
<classLabel>Corticotroph Adenoma</classLabel>
<deletedAxiom>&apos;Corticotroph Adenoma&apos; EquivalentTo &apos;Pituitary Gland Adenoma&apos; and &apos;ACTH-Producing Pituitary Gland Neoplasm&apos; and (&apos;Disease_Mapped_To_Gene&apos; some &apos;USP8 Gene&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;USP8 Gene Mutation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;EGFR Protein Overexpression&apos;)</deletedAxiom>
<newAxiom>&apos;Corticotroph Adenoma&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187087 and (&apos;Disease_Has_Normal_Cell_Origin&apos; some &apos;Corticotroph Cell&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Corticotroph Cell&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;USP8 Gene&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;USP8 Gene Mutation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;EGFR Protein Overexpression&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26352</classIRI>
<classLabel>Galectin-8</classLabel>
<deletedAxiom>&apos;Galectin-8&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ligand Binding Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunoregulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Carbohydrate Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LGALS8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Galectin-8&apos; EquivalentTo &apos;Ligand Binding Protein&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Extracellular Space&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Apoptosis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Immunoregulation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Protein-Carbohydrate Interaction&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Cycle Regulation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Adhesion Process&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LGALS8 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12497</classIRI>
<classLabel>Sella Turcica</classLabel>
<newAxiom>&apos;Sella Turcica&apos; SubClassOf &apos;Anatomic_Structure_Is_Physical_Part_Of&apos; some &apos;Sellar Region&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C46111</classIRI>
<classLabel>Thyroid Gland Follicular Adenoma with Papillary Hyperplasia</classLabel>
<deletedAxiom>&apos;Thyroid Gland Follicular Adenoma with Papillary Hyperplasia&apos; EquivalentTo &apos;Thyroid Gland Follicular Adenoma&apos; and &apos;Papillary Adenoma&apos; and (&apos;Disease_Has_Finding&apos; some &apos;Papillary Pattern&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Multifocal Lesion&apos;)</deletedAxiom>
<newAxiom>&apos;Thyroid Gland Follicular Adenoma with Papillary Hyperplasia&apos; EquivalentTo &apos;Thyroid Gland Follicular Adenoma&apos; and &apos;Papillary Adenoma&apos; and (&apos;Disease_May_Have_Finding&apos; some &apos;Multifocal Lesion&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12878</classIRI>
<classLabel>Cardiac Vein</classLabel>
<deletedAxiom>&apos;Cardiac Vein&apos; SubClassOf &apos;Vein&apos;</deletedAxiom>
<newAxiom>&apos;Cardiac Vein&apos; SubClassOf &apos;Coronary Vein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12882</classIRI>
<classLabel>Coronary Vein</classLabel>
<deletedAxiom>&apos;Coronary Vein&apos; SubClassOf &apos;Cardiac Vein&apos;</deletedAxiom>
<newAxiom>&apos;Coronary Vein&apos; SubClassOf &apos;Vein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176789</classIRI>
<classLabel>PQ/CMC Co-Packaged Indicator Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Co-Packaged Indicator Terminology&apos; SubClassOf &apos;FDA Pharmaceutical Quality/CMC Terminology&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Co-Packaged Indicator Terminology&apos; SubClassOf &apos;Unused Subset Concept&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176587</classIRI>
<classLabel>TP53-Associated Li-Fraumeni Syndrome</classLabel>
<deletedAxiom>&apos;TP53-Associated Li-Fraumeni Syndrome&apos; SubClassOf &apos;Li-Fraumeni Syndrome&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71714</classIRI>
<classLabel>Refractory Childhood Spinal Cord Neoplasm</classLabel>
<deletedAxiom>&apos;Refractory Childhood Spinal Cord Neoplasm&apos; EquivalentTo &apos;Refractory Spinal Cord Neoplasm&apos; and &apos;Childhood Spinal Cord Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Refractory Childhood Spinal Cord Neoplasm&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187214 and &apos;Refractory Spinal Cord Neoplasm&apos; and &apos;Childhood Spinal Cord Neoplasm&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176319</classIRI>
<classLabel>Caudal Vertebra</classLabel>
<deletedAxiom>&apos;Caudal Vertebra&apos; SubClassOf &apos;Vertebra&apos;</deletedAxiom>
<newAxiom>&apos;Caudal Vertebra&apos; SubClassOf &apos;Experimental Organism Anatomical Concept&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C32390</classIRI>
<classLabel>Corticotroph Cell</classLabel>
<deletedAxiom>&apos;Corticotroph Cell&apos; SubClassOf &apos;Anatomic_Structure_Is_Physical_Part_Of&apos; some &apos;Anterior Lobe of the Pituitary Gland&apos;</deletedAxiom>
<newAxiom>&apos;Corticotroph Cell&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187079</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C32691</classIRI>
<classLabel>Gonadotroph Cell</classLabel>
<deletedAxiom>&apos;Gonadotroph Cell&apos; SubClassOf &apos;Anatomic_Structure_Is_Physical_Part_Of&apos; some &apos;Anterior Lobe of the Pituitary Gland&apos;</deletedAxiom>
<newAxiom>&apos;Gonadotroph Cell&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187078</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C32911</classIRI>
<classLabel>Lactotroph Cell</classLabel>
<newAxiom>&apos;Lactotroph Cell&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187077</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C180413</classIRI>
<classLabel>Anti-Claudin18.2 ADC CMG901</classLabel>
<deletedAxiom>&apos;Anti-Claudin18.2 ADC CMG901&apos; SubClassOf &apos;Anti-claudin18.2 Monoclonal Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Anti-Claudin18.2 ADC CMG901&apos; SubClassOf &apos;Immunoconjugate&apos;</newAxiom>
<newAxiom>&apos;Anti-Claudin18.2 ADC CMG901&apos; SubClassOf &apos;Antineoplastic Antibody-Drug Conjugate&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C121818</classIRI>
<classLabel>Worry about Future Financial Problems as a Result of Illness or Treatment</classLabel>
<newAxiom>&apos;Worry about Future Financial Problems as a Result of Illness or Treatment&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
</changedClass>
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<classLabel>Cancer or Treatment has Reduced Satisfaction with Present Financial Situation</classLabel>
<newAxiom>&apos;Cancer or Treatment has Reduced Satisfaction with Present Financial Situation&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
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<classLabel>Feel Financially Stressed</classLabel>
<newAxiom>&apos;Feel Financially Stressed&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</newAxiom>
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<classLabel>Feel in Control of Financial Situation</classLabel>
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<classLabel>Satisfied with Current Financial Situation</classLabel>
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<deletedAxiom>&apos;Pituitary Gland Blastoma&apos; EquivalentTo &apos;Anterior Pituitary Gland Neoplasm&apos; and &apos;Malignant Pituitary Gland Neoplasm&apos; and &apos;Blastoma&apos; and (&apos;Disease_Has_Molecular_Abnormality&apos; some &apos;Germline DICER1 Loss of Function Gene Mutation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;DICER1 Gene Alteration Positive&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Aggressive Clinical Course&apos;) and (&apos;Disease_Has_Associated_Disease&apos; some &apos;Cushing Disease&apos;) and (&apos;Disease_Mapped_To_Gene&apos; some &apos;DICER1 Gene&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;Somatic DICER1 RNase IIIb Hotspot Gene Mutation&apos;)</deletedAxiom>
<newAxiom>&apos;Pituitary Gland Blastoma&apos; EquivalentTo &apos;Anterior Pituitary Gland Neoplasm&apos; and &apos;Malignant Pituitary Gland Neoplasm&apos; and &apos;Blastoma&apos; and (&apos;Disease_Has_Molecular_Abnormality&apos; some &apos;Germline DICER1 Loss of Function Gene Mutation&apos;) and (&apos;Disease_May_Have_Finding&apos; some &apos;Aggressive Clinical Course&apos;) and (&apos;Disease_Has_Associated_Disease&apos; some &apos;Cushing Disease&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;Somatic DICER1 RNase IIIb Hotspot Gene Mutation&apos;)</newAxiom>
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<classLabel>ERBB2 NM_004448.3:c.2305GC</classLabel>
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<classLabel>ERBB2 NP_004439.2:p.E321G</classLabel>
<deletedAxiom>&apos;ERBB2 NP_004439.2:p.E321G&apos; SubClassOf &apos;Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant&apos; some &apos;Activating ERBB2 Mutation&apos;</deletedAxiom>
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<classLabel>ERBB2 NM_004448.3:c.962AG</classLabel>
<deletedAxiom>&apos;ERBB2 NM_004448.3:c.962AG&apos; SubClassOf &apos;ERBB2 Gene Mutation&apos;</deletedAxiom>
<newAxiom>&apos;ERBB2 NM_004448.3:c.962AG&apos; SubClassOf &apos;Activating ERBB2 Point Mutation&apos;</newAxiom>
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<classLabel>ERBB2 NM_004448.3:c.2305GT</classLabel>
<newAxiom>&apos;ERBB2 NM_004448.3:c.2305GT&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187198</newAxiom>
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<classLabel>WWTR1/CAMTA1 Fusion Gene</classLabel>
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<classLabel>t(11;14)(q13;q32)</classLabel>
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<classLabel>t(2;5)(p23;q35)</classLabel>
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<classLabel>Thyroid Gland Well-Differentiated Tumor of Uncertain Malignant Potential</classLabel>
<deletedAxiom>&apos;Thyroid Gland Well-Differentiated Tumor of Uncertain Malignant Potential&apos; EquivalentTo &apos;Thyroid Gland Neoplasm&apos; and &apos;Encapsulated Neoplasm&apos; and &apos;Neoplasm of Uncertain Malignant Potential&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Thyroid Gland&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Questionable Invasive Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Atypia&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Ground Glass Nuclear Inclusion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Follicular Cell Differentiation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Follicular Structures Present&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Clearing&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Grooves&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;KRAS Gene Mutation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;NRAS Gene Mutation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;HRAS Gene Mutation&apos;)</deletedAxiom>
<newAxiom>&apos;Thyroid Gland Well-Differentiated Tumor of Uncertain Malignant Potential&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187284 and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Atypia&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Ground Glass Nuclear Inclusion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Clearing&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Nuclear Grooves&apos;)</newAxiom>
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<classLabel>Rucaparib Regimen</classLabel>
<newAxiom>&apos;Rucaparib Regimen&apos; SubClassOf &apos;Regimen Used to Treat Pancreatic Carcinoma&apos;</newAxiom>
<newAxiom>&apos;Rucaparib Regimen&apos; SubClassOf &apos;Regimen Used to Treat Prostate Carcinoma&apos;</newAxiom>
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<classLabel>t(9;22)(q34.1;q11.2)</classLabel>
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<classLabel>Isolated Follicle Stimulating Hormone Deficiency</classLabel>
<deletedAxiom>&apos;Isolated Follicle Stimulating Hormone Deficiency&apos; SubClassOf &apos;Hormone Imbalance&apos;</deletedAxiom>
<newAxiom>&apos;Isolated Follicle Stimulating Hormone Deficiency&apos; SubClassOf &apos;Follicle Stimulating Hormone Deficiency&apos;</newAxiom>
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<classLabel>Ruxolitinib Regimen</classLabel>
<newAxiom>&apos;Ruxolitinib Regimen&apos; SubClassOf &apos;Regimen Used to Treat Hematopoietic and Lymphoid Cell Neoplasm&apos;</newAxiom>
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<classLabel>Rituximab and Hyaluronidase Human Regimen</classLabel>
<newAxiom>&apos;Rituximab and Hyaluronidase Human Regimen&apos; SubClassOf &apos;Chemotherapy_Regimen_Has_Component&apos; some &apos;Recombinant Human Hyaluronidase&apos;</newAxiom>
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<changedClass>
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<classLabel>Regorafenib Regimen</classLabel>
<deletedAxiom>&apos;Regorafenib Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Intestinal Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Regorafenib Regimen&apos; SubClassOf &apos;Regimen Used to Treat Central Nervous System Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Regorafenib Regimen&apos; SubClassOf &apos;Regimen Used to Treat Malignant Soft Tissue Neoplasm&apos;</newAxiom>
<newAxiom>&apos;Regorafenib Regimen&apos; SubClassOf &apos;Regimen Used to Treat Bone Cancer&apos;</newAxiom>
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<classLabel>Locally Advanced Distal Bile Duct Carcinoma</classLabel>
<deletedAxiom>&apos;Locally Advanced Distal Bile Duct Carcinoma&apos; EquivalentTo &apos;Locally Advanced Bile Duct Carcinoma&apos; and &apos;Metastatic Distal Bile Duct Carcinoma&apos;</deletedAxiom>
<newAxiom>&apos;Locally Advanced Distal Bile Duct Carcinoma&apos; EquivalentTo &apos;Metastatic Distal Bile Duct Carcinoma&apos; and http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187244</newAxiom>
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<classLabel>Childhood Acute Myeloid Leukemia</classLabel>
<deletedAxiom>&apos;Childhood Acute Myeloid Leukemia&apos; EquivalentTo &apos;Acute Myeloid Leukemia&apos; and &apos;Childhood Leukemia&apos; and (&apos;Disease_May_Have_Finding&apos; some &apos;Hypercellular Bone Marrow&apos;)</deletedAxiom>
<newAxiom>&apos;Childhood Acute Myeloid Leukemia&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187056 and &apos;Acute Myeloid Leukemia&apos;</newAxiom>
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<classLabel>Somatotroph Cell</classLabel>
<newAxiom>&apos;Somatotroph Cell&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187077</newAxiom>
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<classLabel>Thyrotroph Cell</classLabel>
<newAxiom>&apos;Thyrotroph Cell&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187077</newAxiom>
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<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C180884</classIRI>
<classLabel>Anti-claudin18.2/Anti-4-1BB Bispecific Antibody TJ-CD4B</classLabel>
<deletedAxiom>&apos;Anti-claudin18.2/Anti-4-1BB Bispecific Antibody TJ-CD4B&apos; SubClassOf &apos;Antineoplastic Antibody&apos;</deletedAxiom>
<newAxiom>&apos;Anti-claudin18.2/Anti-4-1BB Bispecific Antibody TJ-CD4B&apos; SubClassOf &apos;Anti-claudin18.2 Monoclonal Antibody&apos;</newAxiom>
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<classLabel>Thyroid Gland Follicular Tumor of Uncertain Malignant Potential</classLabel>
<deletedAxiom>&apos;Thyroid Gland Follicular Tumor of Uncertain Malignant Potential&apos; EquivalentTo &apos;Thyroid Gland Neoplasm&apos; and &apos;Encapsulated Neoplasm&apos; and &apos;Neoplasm of Uncertain Malignant Potential&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Thyroid Gland&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Questionable Invasive Lesion&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Follicular Cell Differentiation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Follicular Structures Present&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Ground Glass Nuclear Inclusion&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Nuclear Clearing&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Nuclear Grooves&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;KRAS Gene Mutation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;NRAS Gene Mutation&apos;) and (&apos;Disease_May_Have_Molecular_Abnormality&apos; some &apos;HRAS Gene Mutation&apos;)</deletedAxiom>
<newAxiom>&apos;Thyroid Gland Follicular Tumor of Uncertain Malignant Potential&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187284 and (&apos;Disease_Excludes_Finding&apos; some &apos;Ground Glass Nuclear Inclusion&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Nuclear Clearing&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Nuclear Grooves&apos;)</newAxiom>
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<classLabel>Sellar Ependymoma</classLabel>
<deletedAxiom>&apos;Sellar Ependymoma&apos; EquivalentTo &apos;Brain Ependymoma&apos; and &apos;Posterior Pituitary Gland Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Sellar Ependymoma&apos; EquivalentTo &apos;Posterior Pituitary Gland Neoplasm&apos; and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Oncocyte&apos;) and (&apos;Disease_Has_Abnormal_Cell&apos; some &apos;Neoplastic Epithelioid Cell&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Rosette Formation&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Perivascular Pseudorosette Formation&apos;)</newAxiom>
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<classLabel>Pituitary Gland Paraganglioma</classLabel>
<deletedAxiom>&apos;Pituitary Gland Paraganglioma&apos; EquivalentTo &apos;Pituitary Gland Neoplasm&apos; and &apos;Central Nervous System Paraganglioma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Pituitary Gland&apos;)</deletedAxiom>
<newAxiom>&apos;Pituitary Gland Paraganglioma&apos; EquivalentTo &apos;Sellar Region Neoplasm&apos; and &apos;Central Nervous System Paraganglioma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Sellar Region&apos;)</newAxiom>
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<classLabel>CHART-SF Paper Version - Economic Self-sufficiency Subscore</classLabel>
<newAxiom>'CHART-SF Paper Version - Economic Self-sufficiency Subscore' SubClassOf 'CHART-SF Paper Version Questionnaire Question'</newAxiom>
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<newAxiom>'CHART-SF Paper Version - Total Score' SubClassOf 'CHART-SF Paper Version Questionnaire Question'</newAxiom>
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<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - DSM-5 Other Diagnosis 2' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
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<newAxiom>'Craig Handicap Assessment and Reporting Technique-Short Form - Unpaid Personal Care per Day' SubClassOf 'Craig Handicap Assessment and Reporting Technique-Short Form Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187469</classIRI>
<classLabel>Craig Handicap Assessment and Reporting Technique-Short Form - Home Cognitive Assistance per Day</classLabel>
<newAxiom>'Craig Handicap Assessment and Reporting Technique-Short Form - Home Cognitive Assistance per Day' SubClassOf 'Craig Handicap Assessment and Reporting Technique-Short Form Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187466</classIRI>
<classLabel>Hamilton Depression Rating Scale - 17 Item - Total Score for Analysis</classLabel>
<newAxiom>'Hamilton Depression Rating Scale - 17 Item - Total Score for Analysis' SubClassOf 'HAMD-17 Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187467</classIRI>
<classLabel>Craig Handicap Assessment and Reporting Technique-Short Form - Paid Personal Care per Day</classLabel>
<newAxiom>'Craig Handicap Assessment and Reporting Technique-Short Form - Paid Personal Care per Day' SubClassOf 'Craig Handicap Assessment and Reporting Technique-Short Form Questionnaire Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187460</classIRI>
<classLabel>Stanford Sleepiness Scale Questionnaire Question</classLabel>
<newAxiom>'Stanford Sleepiness Scale Questionnaire Question' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187461</classIRI>
<classLabel>Craig Handicap Assessment and Reporting Technique-Short Form Questionnaire Question</classLabel>
<newAxiom>'Craig Handicap Assessment and Reporting Technique-Short Form Questionnaire Question' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187453</classIRI>
<classLabel>CDISC Questionnaire Stanford Sleepiness Scale Test Name Terminology</classLabel>
<newAxiom>'CDISC Questionnaire Stanford Sleepiness Scale Test Name Terminology' SubClassOf 'CDISC Questionnaire Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187454</classIRI>
<classLabel>CDISC Questionnaire Stanford Sleepiness Scale Test Code Terminology</classLabel>
<newAxiom>'CDISC Questionnaire Stanford Sleepiness Scale Test Code Terminology' SubClassOf 'CDISC Questionnaire Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187451</classIRI>
<classLabel>CDISC Clinical Classification Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Test Name Terminology</classLabel>
<newAxiom>'CDISC Clinical Classification Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Test Name Terminology' SubClassOf 'CDISC Clinical Classification Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187452</classIRI>
<classLabel>CDISC Clinical Classification Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Test Code Terminology</classLabel>
<newAxiom>'CDISC Clinical Classification Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Test Code Terminology' SubClassOf 'CDISC Clinical Classification Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187457</classIRI>
<classLabel>CDISC ADaM Craig Handicap Assessment and Reporting Technique-Short Form Questionnaires Parameter Name Terminology</classLabel>
<newAxiom>'CDISC ADaM Craig Handicap Assessment and Reporting Technique-Short Form Questionnaires Parameter Name Terminology' SubClassOf 'CDISC ADaM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187458</classIRI>
<classLabel>CDISC ADaM Craig Handicap Assessment and Reporting Technique-Short Form Questionnaires Parameter Code Terminology</classLabel>
<newAxiom>'CDISC ADaM Craig Handicap Assessment and Reporting Technique-Short Form Questionnaires Parameter Code Terminology' SubClassOf 'CDISC ADaM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187455</classIRI>
<classLabel>CDISC ADaM Hamilton Depression Rating Scale - 17 Item Clinical Classification Parameter Name Terminology</classLabel>
<newAxiom>'CDISC ADaM Hamilton Depression Rating Scale - 17 Item Clinical Classification Parameter Name Terminology' SubClassOf 'CDISC ADaM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187456</classIRI>
<classLabel>CDISC ADaM Hamilton Depression Rating Scale - 17 Item Clinical Classification Parameter Code Terminology</classLabel>
<newAxiom>'CDISC ADaM Hamilton Depression Rating Scale - 17 Item Clinical Classification Parameter Code Terminology' SubClassOf 'CDISC ADaM Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187459</classIRI>
<classLabel>Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question </classLabel>
<newAxiom>'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question ' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187450</classIRI>
<classLabel>Oligometastatic Pancreatic Ductal Adenocarcinoma</classLabel>
<newAxiom>'Oligometastatic Pancreatic Ductal Adenocarcinoma' EquivalentTo 'Metastatic Pancreatic Ductal Adenocarcinoma' and ('Disease_Has_Finding' some 'Oligometastatic Disease')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187442</classIRI>
<classLabel>Monekypox Virus</classLabel>
<newAxiom>'Monekypox Virus' SubClassOf 'Orthopoxvirus'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187443</classIRI>
<classLabel>Cyclin-Dependent Kinase 11A</classLabel>
<newAxiom>'Cyclin-Dependent Kinase 11A' EquivalentTo 'Cyclin-Dependent Kinase' and ('Gene_Product_Malfunction_Associated_With_Disease' some 'Neuroblastoma') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Apoptosis') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Inhibition of Cell Proliferation') and ('Gene_Product_Encoded_By_Gene' some 'CDK11A Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187440</classIRI>
<classLabel>Chordopoxvirinae</classLabel>
<newAxiom>'Chordopoxvirinae' SubClassOf 'Poxvirus'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187441</classIRI>
<classLabel>Entomopoxvirinae</classLabel>
<newAxiom>'Entomopoxvirinae' SubClassOf 'Poxvirus'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187447</classIRI>
<classLabel>A53 Diffuse Large B-Cell Lymphoma</classLabel>
<newAxiom>'A53 Diffuse Large B-Cell Lymphoma' EquivalentTo 'Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes' and ('Disease_Mapped_To_Gene' some 'TP53 Gene') and ('Disease_May_Have_Molecular_Abnormality' some 'TP53 Gene Mutation') and ('Disease_May_Have_Molecular_Abnormality' some 'TP53 Gene Deletion')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187444</classIRI>
<classLabel>SGK1 Gene Mutation</classLabel>
<newAxiom>'SGK1 Gene Mutation' SubClassOf 'Gene Variant'</newAxiom>
<newAxiom>'SGK1 Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'SGK1 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187445</classIRI>
<classLabel>ST2 Diffuse Large B-Cell Lymphoma</classLabel>
<newAxiom>'ST2 Diffuse Large B-Cell Lymphoma' EquivalentTo 'Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes' and ('Disease_Mapped_To_Gene' some 'SGK1 Gene') and ('Disease_Mapped_To_Gene' some 'TET2 Gene') and ('Disease_May_Have_Molecular_Abnormality' some 'TET2 Gene Mutation') and ('Disease_May_Have_Molecular_Abnormality' some 'SGK1 Gene Mutation')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187448</classIRI>
<classLabel>Resectable Malignant Bone Neoplasm</classLabel>
<newAxiom>'Resectable Malignant Bone Neoplasm' EquivalentTo 'Resectable Malignant Neoplasm' and 'Malignant Bone Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187449</classIRI>
<classLabel>Refractory Childhood Acute Myeloid Leukemia</classLabel>
<newAxiom>'Refractory Childhood Acute Myeloid Leukemia' EquivalentTo 'Refractory Acute Myeloid Leukemia' and 'Refractory Childhood Malignant Neoplasm' and 'Childhood Acute Myeloid Leukemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187431</classIRI>
<classLabel>Zinc Finger Protein GLIS3</classLabel>
<newAxiom>'Zinc Finger Protein GLIS3' EquivalentTo 'Transcription Factor' and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'C2H2 Zinc Finger') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cell Differentiation Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Organogenesis') and ('Gene_Product_Encoded_By_Gene' some 'GLIS3 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187432</classIRI>
<classLabel>GLIS1 Gene Rearrangement</classLabel>
<newAxiom>'GLIS1 Gene Rearrangement' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'GLIS1 Gene'</newAxiom>
<newAxiom>'GLIS1 Gene Rearrangement' SubClassOf 'GLIS Gene Rearrangement'</newAxiom>
<newAxiom>'GLIS1 Gene Rearrangement' SubClassOf 'Chromosome 1 Abnormality'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187430</classIRI>
<classLabel>GLIS3 wt Allele</classLabel>
<newAxiom>'GLIS3 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '9p24.2'</newAxiom>
<newAxiom>'GLIS3 wt Allele' SubClassOf 'GLIS3 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187435</classIRI>
<classLabel>PAX8/GLIS1 Fusion Protein</classLabel>
<newAxiom>'PAX8/GLIS1 Fusion Protein' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Activation'</newAxiom>
<newAxiom>'PAX8/GLIS1 Fusion Protein' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'PAX8/GLIS1 Fusion Gene'</newAxiom>
<newAxiom>'PAX8/GLIS1 Fusion Protein' SubClassOf 'Fusion Protein'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187436</classIRI>
<classLabel>PAX8/GLIS3 Fusion Gene</classLabel>
<newAxiom>'PAX8/GLIS3 Fusion Gene' SubClassOf 'Fusion Gene'</newAxiom>
<newAxiom>'PAX8/GLIS3 Fusion Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Regulation'</newAxiom>
<newAxiom>'PAX8/GLIS3 Fusion Gene' SubClassOf 'Gene_Involved_In_Pathogenesis_Of_Disease' some 'Thyroid Gland Hyalinizing Trabecular Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187433</classIRI>
<classLabel>GLIS3 Gene Rearrangement</classLabel>
<newAxiom>'GLIS3 Gene Rearrangement' SubClassOf 'Chromosome 9 Abnormality'</newAxiom>
<newAxiom>'GLIS3 Gene Rearrangement' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'GLIS3 Gene'</newAxiom>
<newAxiom>'GLIS3 Gene Rearrangement' SubClassOf 'GLIS Gene Rearrangement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187434</classIRI>
<classLabel>PAX8/GLIS1 Fusion Gene</classLabel>
<newAxiom>'PAX8/GLIS1 Fusion Gene' SubClassOf 'Fusion Gene'</newAxiom>
<newAxiom>'PAX8/GLIS1 Fusion Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Regulation'</newAxiom>
<newAxiom>'PAX8/GLIS1 Fusion Gene' SubClassOf 'Gene_Involved_In_Pathogenesis_Of_Disease' some 'Thyroid Gland Hyalinizing Trabecular Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187439</classIRI>
<classLabel>CDK11A wt Allele</classLabel>
<newAxiom>'CDK11A wt Allele' SubClassOf 'CDK11A Gene'</newAxiom>
<newAxiom>'CDK11A wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '1p36.33'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187437</classIRI>
<classLabel>PAX8/GLIS3 Fusion Protein</classLabel>
<newAxiom>'PAX8/GLIS3 Fusion Protein' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'PAX8/GLIS3 Fusion Gene'</newAxiom>
<newAxiom>'PAX8/GLIS3 Fusion Protein' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Activation'</newAxiom>
<newAxiom>'PAX8/GLIS3 Fusion Protein' SubClassOf 'Fusion Protein'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187438</classIRI>
<classLabel>CDK11A Gene</classLabel>
<newAxiom>'CDK11A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Inhibition of Cell Proliferation'</newAxiom>
<newAxiom>'CDK11A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Apoptosis'</newAxiom>
<newAxiom>'CDK11A Gene' SubClassOf 'Gene_Associated_With_Disease' some 'Neuroblastoma'</newAxiom>
<newAxiom>'CDK11A Gene' SubClassOf 'Cyclin-Dependent Kinase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187420</classIRI>
<classLabel>OR2H1 Gene</classLabel>
<newAxiom>'OR2H1 Gene' SubClassOf 'G Protein-Coupled Receptor Gene'</newAxiom>
<newAxiom>'OR2H1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Olfaction'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187421</classIRI>
<classLabel>OR2H1 wt Allele</classLabel>
<newAxiom>'OR2H1 wt Allele' EquivalentTo 'OR2H1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Olfactory Transduction Pathway') and ('Gene_In_Chromosomal_Location' some '6p22.1')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187424</classIRI>
<classLabel>Long-acting Nicotine Replacement Therapy</classLabel>
<newAxiom>'Long-acting Nicotine Replacement Therapy' SubClassOf 'Smoking Cessation Intervention'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187425</classIRI>
<classLabel>GLIS1 Gene</classLabel>
<newAxiom>'GLIS1 Gene' SubClassOf 'Transcription Factor Gene'</newAxiom>
<newAxiom>'GLIS1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cell Differentiation Process'</newAxiom>
<newAxiom>'GLIS1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187422</classIRI>
<classLabel>Olfactory Receptor 2H1</classLabel>
<newAxiom>'Olfactory Receptor 2H1' EquivalentTo 'G Protein-Coupled Receptor' and ('Gene_Product_Is_Element_In_Pathway' some 'Olfactory Transduction Pathway') and ('Gene_Product_Has_Biochemical_Function' some 'Cell Surface Receptor') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Olfaction') and ('Gene_Product_Encoded_By_Gene' some 'OR2H1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187423</classIRI>
<classLabel>Short-acting Nicotine Replacement Therapy</classLabel>
<newAxiom>'Short-acting Nicotine Replacement Therapy' SubClassOf 'Smoking Cessation Intervention'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187428</classIRI>
<classLabel>Zinc Finger Protein GLIS1</classLabel>
<newAxiom>'Zinc Finger Protein GLIS1' EquivalentTo 'Transcription Factor' and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'C2H2 Zinc Finger') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Nuclear Localization Signal') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cell Differentiation Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Encoded_By_Gene' some 'GLIS1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187429</classIRI>
<classLabel>GLIS3 Gene</classLabel>
<newAxiom>'GLIS3 Gene' SubClassOf 'Transcription Factor Gene'</newAxiom>
<newAxiom>'GLIS3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cell Differentiation Process'</newAxiom>
<newAxiom>'GLIS3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Organogenesis'</newAxiom>
<newAxiom>'GLIS3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187427</classIRI>
<classLabel>GLIS1 wt Allele</classLabel>
<newAxiom>'GLIS1 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '1p32.3'</newAxiom>
<newAxiom>'GLIS1 wt Allele' SubClassOf 'GLIS1 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187410</classIRI>
<classLabel>WWTR1 Gene Rearrangement</classLabel>
<newAxiom>'WWTR1 Gene Rearrangement' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'WWTR1 Gene'</newAxiom>
<newAxiom>'WWTR1 Gene Rearrangement' SubClassOf 'Gene Rearrangement Abnormality'</newAxiom>
<newAxiom>'WWTR1 Gene Rearrangement' SubClassOf 'Rearrangement of 3q'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187413</classIRI>
<classLabel>Locally Advanced Unresectable Gallbladder Carcinoma</classLabel>
<newAxiom>'Locally Advanced Unresectable Gallbladder Carcinoma' EquivalentTo 'Locally Advanced Unresectable Carcinoma' and 'Locally Advanced Gallbladder Carcinoma' and 'Unresectable Gallbladder Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187414</classIRI>
<classLabel>HSD17B11 Gene</classLabel>
<newAxiom>'HSD17B11 Gene' SubClassOf 'Oxidoreductase Gene'</newAxiom>
<newAxiom>'HSD17B11 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Steroid Metabolic Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187411</classIRI>
<classLabel>Locally Advanced Unresectable Lung Non-Small Cell Squamous Carcinoma</classLabel>
<newAxiom>'Locally Advanced Unresectable Lung Non-Small Cell Squamous Carcinoma' EquivalentTo 'Locally Advanced Unresectable Carcinoma' and 'Locally Advanced Lung Non-Small Cell Squamous Carcinoma' and 'Unresectable Lung Non-Small Cell Squamous Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187412</classIRI>
<classLabel>Locally Advanced Unresectable Cholangiocarcinoma</classLabel>
<newAxiom>'Locally Advanced Unresectable Cholangiocarcinoma' EquivalentTo 'Locally Advanced Unresectable Carcinoma' and 'Locally Advanced Cholangiocarcinoma' and 'Unresectable Cholangiocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187417</classIRI>
<classLabel>GPR65 Gene</classLabel>
<newAxiom>'GPR65 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Lipid Binding'</newAxiom>
<newAxiom>'GPR65 Gene' SubClassOf 'G Protein-Coupled Receptor Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187418</classIRI>
<classLabel>GPR65 wt Allele</classLabel>
<newAxiom>'GPR65 wt Allele' SubClassOf 'GPR65 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187415</classIRI>
<classLabel>HSD17B11 wt Allele</classLabel>
<newAxiom>'HSD17B11 wt Allele' SubClassOf 'HSD17B11 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187416</classIRI>
<classLabel>Estradiol 17-Beta-Dehydrogenase 11</classLabel>
<newAxiom>'Estradiol 17-Beta-Dehydrogenase 11' SubClassOf 'Oxidoreductase'</newAxiom>
<newAxiom>'Estradiol 17-Beta-Dehydrogenase 11' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'HSD17B11 Gene'</newAxiom>
<newAxiom>'Estradiol 17-Beta-Dehydrogenase 11' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Steroid Metabolic Process'</newAxiom>
<newAxiom>'Estradiol 17-Beta-Dehydrogenase 11' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Endoplasmic Reticulum'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187419</classIRI>
<classLabel>Psychosine Receptor</classLabel>
<newAxiom>'Psychosine Receptor' EquivalentTo 'G Protein-Coupled Receptor' and ('Gene_Product_Has_Chemical_Classification' some 'Transmembrane Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Transmembrane Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Lipid Binding') and ('Gene_Product_Encoded_By_Gene' some 'GPR65 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187402</classIRI>
<classLabel>Locally Advanced Unresectable Triple-Negative Breast Carcinoma</classLabel>
<newAxiom>'Locally Advanced Unresectable Triple-Negative Breast Carcinoma' EquivalentTo 'Locally Advanced Unresectable Breast Carcinoma' and 'Unresectable Triple-Negative Breast Carcinoma' and 'Locally Advanced Triple-Negative Breast Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187403</classIRI>
<classLabel>Babysitter</classLabel>
<newAxiom>'Babysitter' SubClassOf 'Person'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187400</classIRI>
<classLabel>Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma</classLabel>
<newAxiom>'Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma' EquivalentTo 'Locally Advanced Unresectable Breast Carcinoma' and 'Unresectable Hormone Receptor-Positive Breast Carcinoma' and 'Locally Advanced Hormone Receptor-Positive Breast Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187401</classIRI>
<classLabel>Antigen-Presenting Cancer-Associated Fibroblast</classLabel>
<newAxiom>'Antigen-Presenting Cancer-Associated Fibroblast' SubClassOf 'Cancer-Associated Fibroblast'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187406</classIRI>
<classLabel>Locally Advanced Unresectable Endometrial Carcinoma</classLabel>
<newAxiom>'Locally Advanced Unresectable Endometrial Carcinoma' EquivalentTo 'Locally Advanced Unresectable Carcinoma' and 'Locally Advanced Endometrial Carcinoma' and 'Unresectable Endometrial Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187407</classIRI>
<classLabel>MAPK1 NM_002745.5:c.964GA</classLabel>
<newAxiom>'MAPK1 NM_002745.5:c.964GA' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'MAPK1 NP_002736.3:p.E322K'</newAxiom>
<newAxiom>'MAPK1 NM_002745.5:c.964GA' SubClassOf 'MAPK1 Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187404</classIRI>
<classLabel>Extracellular Mucin Present</classLabel>
<newAxiom>'Extracellular Mucin Present' SubClassOf 'Morphologic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187405</classIRI>
<classLabel>Invasive Breast Lobular Carcinoma with Extracellular Mucin</classLabel>
<newAxiom>'Invasive Breast Lobular Carcinoma with Extracellular Mucin' EquivalentTo 'Invasive Breast Lobular Carcinoma' and ('Disease_Has_Finding' some 'Extracellular Mucin Present')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187408</classIRI>
<classLabel>MAPK1 Protein Variant</classLabel>
<newAxiom>'MAPK1 Protein Variant' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'MAPK1 Gene'</newAxiom>
<newAxiom>'MAPK1 Protein Variant' SubClassOf 'Gene Product Sequence Variation'</newAxiom>
<newAxiom>'MAPK1 Protein Variant' SubClassOf 'Gene_Product_Variant_Of_Gene_Product' some 'Mitogen-Activated Protein Kinase 1'</newAxiom>
<newAxiom>'MAPK1 Protein Variant' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'MAPK1 Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187409</classIRI>
<classLabel>MAPK1 NP_002736.3:p.E322K</classLabel>
<newAxiom>'MAPK1 NP_002736.3:p.E322K' SubClassOf 'MAPK1 Protein Variant'</newAxiom>
<newAxiom>'MAPK1 NP_002736.3:p.E322K' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'MAPK1 NM_002745.5:c.964GA'</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Global Validity</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Global Validity' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Global Severity</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Global Severity' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187594</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Occupation Functioning Past Month</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Occupation Functioning Past Month' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Occupation Functioning Lifetime</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Occupation Functioning Lifetime' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187598</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Global Improvement</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Global Improvement' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Depersonalization</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Depersonalization' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Social Functioning Past Month</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Social Functioning Past Month' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187593</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Social Functioning Lifetime</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Social Functioning Lifetime' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187590</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Subjective Distress Past Month</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Subjective Distress Past Month' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Subjective Distress Lifetime</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Subjective Distress Lifetime' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187585</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms With Delayed Onset</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms With Delayed Onset' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms Current Months Duration</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms Current Months Duration' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187583</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Difficulty Falling Asleep Intensity</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Difficulty Falling Asleep Intensity' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187584</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms Total Months Delay Onset</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms Total Months Delay Onset' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187589</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms Lifetime More Than Month</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms Lifetime More Than Month' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187587</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms Current More Than Month</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms Current More Than Month' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187588</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms Lifetime Months Duration</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Symptoms Lifetime Months Duration' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187581</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Sleep Disturbance</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Sleep Disturbance' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187582</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Difficulty Falling Asleep Frequency</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Difficulty Falling Asleep Frequency' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187580</classIRI>
<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Difficulty Concentrating Intensity</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Difficulty Concentrating Intensity' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Hypervigilance Intensity</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Hypervigilance Intensity' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Exaggerated Response</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Exaggerated Response' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Hypervigilance</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Hypervigilance' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Hypervigilance Frequency</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Hypervigilance Frequency' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Problems With Concentration</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Problems With Concentration' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Difficulty Concentrating Frequency</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Difficulty Concentrating Frequency' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Exaggerated Response Frequency</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Exaggerated Response Frequency' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Exaggerated Response Intensity</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Exaggerated Response Intensity' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Irritability or Outbursts Intensity' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Reckless or Self-destructive</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Reckless or Self-destructive' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Inability Positive Emotions</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Inability Positive Emotions' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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<classLabel>CAPS DSM-5 With DSM IV Scoring 2016 Version - Restricted Range of Affect Frequency</classLabel>
<newAxiom>'CAPS DSM-5 With DSM IV Scoring 2016 Version - Restricted Range of Affect Frequency' SubClassOf 'Clinician-Administered PTSD Scale (Current) DSM-5 With DSM IV Scoring 2016 Version Clinical Classification Question '</newAxiom>
</newClass>
<newClass>
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</newClass>
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<classLabel>Muscle Weakness/Atrophy</classLabel>
<newAxiom>'Muscle Weakness/Atrophy' SubClassOf 'Musculoskeletal Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187272</classIRI>
<classLabel>Low Metastatic Risk</classLabel>
<newAxiom>'Low Metastatic Risk' SubClassOf 'Clinical Course of Disease'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187266</classIRI>
<classLabel>Cause Traced to Artificial Intelligence Training/Validation Process</classLabel>
<newAxiom>'Cause Traced to Artificial Intelligence Training/Validation Process' SubClassOf 'Device Evaluation Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187267</classIRI>
<classLabel>Galacto-oligosaccharide Prebiotic Supplement</classLabel>
<newAxiom>'Galacto-oligosaccharide Prebiotic Supplement' SubClassOf 'Dietary Supplement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187264</classIRI>
<classLabel>Corrupt Software</classLabel>
<newAxiom>'Corrupt Software' SubClassOf 'Device Evaluation Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187265</classIRI>
<classLabel>Reasonably Foreseeable Misuse</classLabel>
<newAxiom>'Reasonably Foreseeable Misuse' SubClassOf 'Device Evaluation Conclusion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187268</classIRI>
<classLabel>Increased Intracranial Pressure</classLabel>
<newAxiom>'Increased Intracranial Pressure' SubClassOf 'Head and Neck Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187269</classIRI>
<classLabel>Autologous Anti-CD5 CAR Monocytes MT-101</classLabel>
<newAxiom>'Autologous Anti-CD5 CAR Monocytes MT-101' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187262</classIRI>
<classLabel>Event History Log Review</classLabel>
<newAxiom>'Event History Log Review' SubClassOf 'Device Evaluation Method'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187263</classIRI>
<classLabel>Artificial Intelligence Training/Validation Problem Identified</classLabel>
<newAxiom>'Artificial Intelligence Training/Validation Problem Identified' SubClassOf 'Device Evaluation Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187260</classIRI>
<classLabel>Neoplastic Cells with Papillary Architecture Present</classLabel>
<newAxiom>'Neoplastic Cells with Papillary Architecture Present' SubClassOf 'Morphologic Architectural Pattern'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187261</classIRI>
<classLabel>Thyroid Gland Follicular Adenoma with Papillary Architecture</classLabel>
<newAxiom>'Thyroid Gland Follicular Adenoma with Papillary Architecture' EquivalentTo 'Thyroid Gland Follicular Adenoma' and ('Disease_Has_Finding' some 'Neoplastic Cells with Papillary Architecture Present') and ('Disease_Excludes_Finding' some 'Psammoma Body Formation') and ('Disease_Excludes_Finding' some 'Nuclear Atypia') and ('Disease_Excludes_Finding' some 'Capsular Invasion') and ('Disease_May_Have_Molecular_Abnormality' some 'Activating TSHR Gene Mutation') and ('Disease_May_Have_Molecular_Abnormality' some 'GNAS Gene Mutation')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187255</classIRI>
<classLabel>Thyroid Gland Follicular Nodular Disease</classLabel>
<newAxiom>'Thyroid Gland Follicular Nodular Disease' SubClassOf 'Non-Neoplastic Thyroid Gland Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187256</classIRI>
<classLabel>Anti-CD39 Monoclonal Antibody PUR001</classLabel>
<newAxiom>'Anti-CD39 Monoclonal Antibody PUR001' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187253</classIRI>
<classLabel>Failure to Seal</classLabel>
<newAxiom>'Failure to Seal' SubClassOf 'Mechanics Altered'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187254</classIRI>
<classLabel>Adhesive Too Strong</classLabel>
<newAxiom>'Adhesive Too Strong' SubClassOf 'Physical Resistance/Sticking'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187259</classIRI>
<classLabel>Wrong Label</classLabel>
<newAxiom>'Wrong Label' SubClassOf 'Device Markings/Labeling Problem'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187257</classIRI>
<classLabel>Poor Visibility</classLabel>
<newAxiom>'Poor Visibility' SubClassOf 'Incorrect, Inadequate or Imprecise Result or Readings'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187258</classIRI>
<classLabel>Succinate Dehydrogenase Deficiency</classLabel>
<newAxiom>'Succinate Dehydrogenase Deficiency' SubClassOf 'Mitochondrial Enzyme Deficiency'</newAxiom>
<newAxiom>'Succinate Dehydrogenase Deficiency' SubClassOf 'Disease_May_Have_Molecular_Abnormality' some 'SDH Complex Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187251</classIRI>
<classLabel>Central Regurgitation Heart Valve</classLabel>
<newAxiom>'Central Regurgitation Heart Valve' SubClassOf 'Leak/Splash'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187252</classIRI>
<classLabel>Powder Leak</classLabel>
<newAxiom>'Powder Leak' SubClassOf 'Leak/Splash'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187250</classIRI>
<classLabel>Personalized Neoantigen Cancer Vaccine VB10.NEO</classLabel>
<newAxiom>'Personalized Neoantigen Cancer Vaccine VB10.NEO' SubClassOf 'Autologous Tumor Cell Vaccine'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187244</classIRI>
<classLabel>Locally Advanced Extrahepatic Bile Duct Carcinoma</classLabel>
<newAxiom>'Locally Advanced Extrahepatic Bile Duct Carcinoma' EquivalentTo 'Locally Advanced Bile Duct Carcinoma' and 'Metastatic Extrahepatic Bile Duct Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187245</classIRI>
<classLabel>Ripretinib Regimen</classLabel>
<newAxiom>'Ripretinib Regimen' SubClassOf 'Regimen Used to Treat Malignant Soft Tissue Neoplasm'</newAxiom>
<newAxiom>'Ripretinib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Ripretinib'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187242</classIRI>
<classLabel>Locally Advanced Ovarian Serous Cystadenocarcinoma</classLabel>
<newAxiom>'Locally Advanced Ovarian Serous Cystadenocarcinoma' EquivalentTo 'Metastatic Ovarian Serous Cystadenocarcinoma' and 'Locally Advanced Ovarian Serous Adenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187243</classIRI>
<classLabel>Locally Advanced Ovarian Serous Adenocarcinoma</classLabel>
<newAxiom>'Locally Advanced Ovarian Serous Adenocarcinoma' EquivalentTo 'Metastatic Ovarian Serous Adenocarcinoma' and 'Locally Advanced Ovarian Carcinoma' and 'Locally Advanced Adenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187248</classIRI>
<classLabel>Device Stenosis</classLabel>
<newAxiom>'Device Stenosis' SubClassOf 'Mechanical Issue'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187249</classIRI>
<classLabel>Extra Component</classLabel>
<newAxiom>'Extra Component' SubClassOf 'Manufacturing, Packaging or Shipping Problem'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187246</classIRI>
<classLabel>Letrozole/Ribociclib Regimen</classLabel>
<newAxiom>'Letrozole/Ribociclib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Letrozole'</newAxiom>
<newAxiom>'Letrozole/Ribociclib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Ribociclib'</newAxiom>
<newAxiom>'Letrozole/Ribociclib Regimen' SubClassOf 'Regimen Used to Treat Breast Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187247</classIRI>
<classLabel>Lack of Effect</classLabel>
<newAxiom>'Lack of Effect' SubClassOf 'Mechanical Issue'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187240</classIRI>
<classLabel>Ropeginterferon Alfa-2b Regimen</classLabel>
<newAxiom>'Ropeginterferon Alfa-2b Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Ropeginterferon Alfa-2B'</newAxiom>
<newAxiom>'Ropeginterferon Alfa-2b Regimen' SubClassOf 'Regimen Used to Treat Malignant Bone Marrow Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187241</classIRI>
<classLabel>Recurrent Ovarian Serous Cystadenocarcinoma</classLabel>
<newAxiom>'Recurrent Ovarian Serous Cystadenocarcinoma' EquivalentTo 'Recurrent Ovarian Serous Adenocarcinoma' and 'Recurrent Ovarian Cystadenocarcinoma' and 'Ovarian Serous Cystadenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187233</classIRI>
<classLabel>Selpercatinib Regimen</classLabel>
<newAxiom>'Selpercatinib Regimen' SubClassOf 'Regimen Used to Treat Non-Small Cell Lung Carcinoma'</newAxiom>
<newAxiom>'Selpercatinib Regimen' SubClassOf 'Regimen Used to Treat Thyroid Cancer'</newAxiom>
<newAxiom>'Selpercatinib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Selpercatinib'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187234</classIRI>
<classLabel>Metastatic Ovarian Serous Cystadenocarcinoma</classLabel>
<newAxiom>'Metastatic Ovarian Serous Cystadenocarcinoma' EquivalentTo 'Metastatic Ovarian Serous Adenocarcinoma' and 'Ovarian Serous Cystadenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187231</classIRI>
<classLabel>Selumetinib Regimen</classLabel>
<newAxiom>'Selumetinib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Selumetinib Sulfate'</newAxiom>
<newAxiom>'Selumetinib Regimen' SubClassOf 'Regimen Used to Treat Central Nervous System Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187232</classIRI>
<classLabel>EGFR Inhibitor ERAS-801</classLabel>
<newAxiom>'EGFR Inhibitor ERAS-801' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'EGFR Inhibitor ERAS-801' SubClassOf 'Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187237</classIRI>
<classLabel>SKd Regimen</classLabel>
<newAxiom>'SKd Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Carfilzomib'</newAxiom>
<newAxiom>'SKd Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Dexamethasone'</newAxiom>
<newAxiom>'SKd Regimen' SubClassOf 'Regimen Used to Treat Plasma Cell Myeloma'</newAxiom>
<newAxiom>'SKd Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Selinexor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187238</classIRI>
<classLabel>Azacitidine/Ruxolitinib Regimen</classLabel>
<newAxiom>'Azacitidine/Ruxolitinib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Azacitidine'</newAxiom>
<newAxiom>'Azacitidine/Ruxolitinib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Ruxolitinib Phosphate'</newAxiom>
<newAxiom>'Azacitidine/Ruxolitinib Regimen' SubClassOf 'Regimen Used to Treat Malignant Bone Marrow Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187235</classIRI>
<classLabel>Advanced Ovarian Serous Cystadenocarcinoma</classLabel>
<newAxiom>'Advanced Ovarian Serous Cystadenocarcinoma' EquivalentTo 'Advanced Ovarian Serous Adenocarcinoma' and 'Metastatic Ovarian Serous Cystadenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187236</classIRI>
<classLabel>Selinexor Regimen</classLabel>
<newAxiom>'Selinexor Regimen' SubClassOf 'Regimen Used to Treat Non-Hodgkin Lymphoma'</newAxiom>
<newAxiom>'Selinexor Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Selinexor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187239</classIRI>
<classLabel>Decitabine/Ruxolitinib Regimen</classLabel>
<newAxiom>'Decitabine/Ruxolitinib Regimen' SubClassOf 'Regimen Used to Treat Malignant Bone Marrow Neoplasm'</newAxiom>
<newAxiom>'Decitabine/Ruxolitinib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Decitabine'</newAxiom>
<newAxiom>'Decitabine/Ruxolitinib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Ruxolitinib Phosphate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187230</classIRI>
<classLabel>Sonidegib Regimen</classLabel>
<newAxiom>'Sonidegib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Sonidegib'</newAxiom>
<newAxiom>'Sonidegib Regimen' SubClassOf 'Regimen Used to Treat Malignant Skin Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187222</classIRI>
<classLabel>Nicotinic Acetylcholine Receptor</classLabel>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Protein or Riboprotein Complex'</newAxiom>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Gated Ion Channel'</newAxiom>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Muscle Contraction'</newAxiom>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Gene_Product_Has_Chemical_Classification' some 'Transmembrane Protein'</newAxiom>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Ion Transport Process'</newAxiom>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Gene_Product_Has_Structural_Domain_Or_Motif' some 'Ligand Binding Domain'</newAxiom>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Gene_Product_Has_Biochemical_Function' some 'Ion Channel Protein'</newAxiom>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane'</newAxiom>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Ligand Binding'</newAxiom>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Neuronal Transmission'</newAxiom>
<newAxiom>'Nicotinic Acetylcholine Receptor' SubClassOf 'Gene_Product_Has_Biochemical_Function' some 'Cell Surface Receptor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187223</classIRI>
<classLabel>EBP Gene</classLabel>
<newAxiom>'EBP Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cholesterol Homeostasis'</newAxiom>
<newAxiom>'EBP Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Biosynthetic Process'</newAxiom>
<newAxiom>'EBP Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Steroid Metabolic Process'</newAxiom>
<newAxiom>'EBP Gene' SubClassOf 'Isomerase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187220</classIRI>
<classLabel>SARS Coronavirus 2 BA.2.12.1</classLabel>
<newAxiom>'SARS Coronavirus 2 BA.2.12.1' SubClassOf 'SARS Coronavirus 2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187221</classIRI>
<classLabel>SARS Coronavirus 2 BA.1</classLabel>
<newAxiom>'SARS Coronavirus 2 BA.1' SubClassOf 'SARS Coronavirus 2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187226</classIRI>
<classLabel>CLDN6 Positive</classLabel>
<newAxiom>'CLDN6 Positive' SubClassOf 'Expression Positive'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187227</classIRI>
<classLabel>Obvious</classLabel>
<newAxiom>'Obvious' SubClassOf 'General Qualifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187224</classIRI>
<classLabel>EBP wt Allele</classLabel>
<newAxiom>'EBP wt Allele' EquivalentTo 'EBP Gene' and ('Gene_Is_Element_In_Pathway' some 'Steroid Hormone Biosynthesis Pathway') and ('Gene_In_Chromosomal_Location' some 'Xp11.23')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187225</classIRI>
<classLabel>3-Beta-Hydroxysteroid-Delta(8),Delta(7)-Isomerase</classLabel>
<newAxiom>'3-Beta-Hydroxysteroid-Delta(8),Delta(7)-Isomerase' EquivalentTo 'Isomerase' and ('Gene_Product_Is_Element_In_Pathway' some 'Steroid Hormone Biosynthesis Pathway') and ('Gene_Product_Has_Chemical_Classification' some 'Transmembrane Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Membrane of the Rough Endoplasmic Reticulum') and ('Gene_Product_Has_Associated_Anatomy' some 'Membrane of the Smooth Endoplasmic Reticulum') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Transmembrane Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Biosynthetic Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Steroid Metabolic Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cholesterol Homeostasis') and ('Gene_Product_Encoded_By_Gene' some 'EBP Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187228</classIRI>
<classLabel>Azacitidine/Sorafenib Regimen</classLabel>
<newAxiom>'Azacitidine/Sorafenib Regimen' SubClassOf 'Regimen Used to Treat Acute Myeloid Leukemia'</newAxiom>
<newAxiom>'Azacitidine/Sorafenib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Sorafenib Tosylate'</newAxiom>
<newAxiom>'Azacitidine/Sorafenib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Azacitidine'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187229</classIRI>
<classLabel>Decitabine/Sorafenib Regimen</classLabel>
<newAxiom>'Decitabine/Sorafenib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Decitabine'</newAxiom>
<newAxiom>'Decitabine/Sorafenib Regimen' SubClassOf 'Regimen Used to Treat Acute Myeloid Leukemia'</newAxiom>
<newAxiom>'Decitabine/Sorafenib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Sorafenib Tosylate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187211</classIRI>
<classLabel>Metastatic Childhood Malignant Neoplasm in the Brain</classLabel>
<newAxiom>'Metastatic Childhood Malignant Neoplasm in the Brain' EquivalentTo 'Childhood Malignant Brain Neoplasm' and 'Metastatic Malignant Neoplasm in the Brain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187212</classIRI>
<classLabel>Metastatic Childhood Malignant Brain Neoplasm</classLabel>
<newAxiom>'Metastatic Childhood Malignant Brain Neoplasm' EquivalentTo 'Metastatic Primary Malignant Brain Neoplasm' and 'Childhood Malignant Brain Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187210</classIRI>
<classLabel>Advanced Childhood Malignant Solid Neoplasm</classLabel>
<newAxiom>'Advanced Childhood Malignant Solid Neoplasm' EquivalentTo 'Advanced Malignant Solid Neoplasm' and 'Childhood Malignant Solid Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187215</classIRI>
<classLabel>Refractory Childhood Brain Neoplasm</classLabel>
<newAxiom>'Refractory Childhood Brain Neoplasm' EquivalentTo 'Refractory Childhood Central Nervous System Neoplasm' and 'Refractory Brain Neoplasm' and 'Childhood Brain Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187216</classIRI>
<classLabel>SARS Coronavirus 2 XE</classLabel>
<newAxiom>'SARS Coronavirus 2 XE' SubClassOf 'SARS Coronavirus 2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187213</classIRI>
<classLabel>Advanced Childhood Malignant Brain Neoplasm</classLabel>
<newAxiom>'Advanced Childhood Malignant Brain Neoplasm' EquivalentTo 'Advanced Primary Malignant Brain Neoplasm' and 'Metastatic Childhood Malignant Brain Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187214</classIRI>
<classLabel>Refractory Childhood Central Nervous System Neoplasm</classLabel>
<newAxiom>'Refractory Childhood Central Nervous System Neoplasm' EquivalentTo 'Childhood Central Nervous System Neoplasm' and 'Refractory Primary Central Nervous System Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187219</classIRI>
<classLabel>SARS Coronavirus 2 BA.3</classLabel>
<newAxiom>'SARS Coronavirus 2 BA.3' SubClassOf 'SARS Coronavirus 2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187217</classIRI>
<classLabel>SARS Coronavirus 2 BA.5</classLabel>
<newAxiom>'SARS Coronavirus 2 BA.5' SubClassOf 'SARS Coronavirus 2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187218</classIRI>
<classLabel>SARS Coronavirus 2 BA.4</classLabel>
<newAxiom>'SARS Coronavirus 2 BA.4' SubClassOf 'SARS Coronavirus 2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187200</classIRI>
<classLabel>Nodule External Feature</classLabel>
<newAxiom>'Nodule External Feature' SubClassOf 'Morphologic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187201</classIRI>
<classLabel>TCGM2004 Germ Cell Tumor Study Identifier</classLabel>
<newAxiom>'TCGM2004 Germ Cell Tumor Study Identifier' SubClassOf 'GCT Study Identifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187204</classIRI>
<classLabel>Level of Confidence</classLabel>
<newAxiom>'Level of Confidence' SubClassOf 'Statistical Technique'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187205</classIRI>
<classLabel>Level of Suspicion</classLabel>
<newAxiom>'Level of Suspicion' SubClassOf 'Diagnostic Accuracy Assessment Criterion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187202</classIRI>
<classLabel>Pericystic</classLabel>
<newAxiom>'Pericystic' SubClassOf 'Anatomy Qualifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187203</classIRI>
<classLabel>Dimpling</classLabel>
<newAxiom>'Dimpling' SubClassOf 'Morphologic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187208</classIRI>
<classLabel>Minimally Invasive Distal Pancreatectomy</classLabel>
<newAxiom>'Minimally Invasive Distal Pancreatectomy' SubClassOf 'Distal Pancreatectomy'</newAxiom>
<newAxiom>'Minimally Invasive Distal Pancreatectomy' SubClassOf 'Minimally Invasive Surgery'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187209</classIRI>
<classLabel>Open Distal Pancreatectomy</classLabel>
<newAxiom>'Open Distal Pancreatectomy' SubClassOf 'Distal Pancreatectomy'</newAxiom>
<newAxiom>'Open Distal Pancreatectomy' SubClassOf 'Open Surgical Procedure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187206</classIRI>
<classLabel>Paracicatricial Emphysema</classLabel>
<newAxiom>'Paracicatricial Emphysema' SubClassOf 'Pulmonary Emphysema'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187207</classIRI>
<classLabel>Childhood Malignant Brain Neoplasm</classLabel>
<newAxiom>'Childhood Malignant Brain Neoplasm' EquivalentTo 'Malignant Brain Neoplasm' and 'Childhood Malignant Central Nervous System Neoplasm' and 'Childhood Brain Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187299</classIRI>
<classLabel>STING-dependent Activators-loaded Autologous Leukemic Cells</classLabel>
<newAxiom>'STING-dependent Activators-loaded Autologous Leukemic Cells' SubClassOf 'Antineoplastic Vaccine'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187297</classIRI>
<classLabel>Mount Sinai Acute Graft Versus Host Disease International Consortium Grade IV</classLabel>
<newAxiom>'Mount Sinai Acute Graft Versus Host Disease International Consortium Grade IV' SubClassOf 'Mount Sinai Acute Graft Versus Host Disease International Consortium Grading System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187298</classIRI>
<classLabel>Anti-Immunoglobulin-beta CAR T Cells</classLabel>
<newAxiom>'Anti-Immunoglobulin-beta CAR T Cells' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Anti-Immunoglobulin-beta CAR T Cells' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187291</classIRI>
<classLabel>Anti-HER2 Bispecific Antibody KM257</classLabel>
<newAxiom>'Anti-HER2 Bispecific Antibody KM257' SubClassOf 'Bispecific Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-HER2 Bispecific Antibody KM257' SubClassOf 'Anti-HER2 Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187292</classIRI>
<classLabel>Mount Sinai Acute Graft Versus Host Disease International Consortium Grading System</classLabel>
<newAxiom>'Mount Sinai Acute Graft Versus Host Disease International Consortium Grading System' SubClassOf 'Disease Grade Qualifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187290</classIRI>
<classLabel>EGFR Mutant-selective Inhibitor BPI-361175</classLabel>
<newAxiom>'EGFR Mutant-selective Inhibitor BPI-361175' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'EGFR Mutant-selective Inhibitor BPI-361175' SubClassOf 'Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187295</classIRI>
<classLabel>Mount Sinai Acute Graft Versus Host Disease International Consortium Grade II</classLabel>
<newAxiom>'Mount Sinai Acute Graft Versus Host Disease International Consortium Grade II' SubClassOf 'Mount Sinai Acute Graft Versus Host Disease International Consortium Grading System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187296</classIRI>
<classLabel>Mount Sinai Acute Graft Versus Host Disease International Consortium Grade III</classLabel>
<newAxiom>'Mount Sinai Acute Graft Versus Host Disease International Consortium Grade III' SubClassOf 'Mount Sinai Acute Graft Versus Host Disease International Consortium Grading System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187293</classIRI>
<classLabel>Mount Sinai Acute Graft Versus Host Disease International Consortium Grade 0</classLabel>
<newAxiom>'Mount Sinai Acute Graft Versus Host Disease International Consortium Grade 0' SubClassOf 'Mount Sinai Acute Graft Versus Host Disease International Consortium Grading System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187294</classIRI>
<classLabel>Mount Sinai Acute Graft Versus Host Disease International Consortium Grade I</classLabel>
<newAxiom>'Mount Sinai Acute Graft Versus Host Disease International Consortium Grade I' SubClassOf 'Mount Sinai Acute Graft Versus Host Disease International Consortium Grading System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187288</classIRI>
<classLabel>Pigment Dispersion Syndrome</classLabel>
<newAxiom>'Pigment Dispersion Syndrome' SubClassOf 'Non-Neoplastic Eye Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187289</classIRI>
<classLabel>Anti-OX40 Agonist Monoclonal Antibody HFB301001</classLabel>
<newAxiom>'Anti-OX40 Agonist Monoclonal Antibody HFB301001' SubClassOf 'Chemical_Or_Drug_Has_Mechanism_Of_Action' some 'Antigen Binding'</newAxiom>
<newAxiom>'Anti-OX40 Agonist Monoclonal Antibody HFB301001' SubClassOf 'Anti-OX40 Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187286</classIRI>
<classLabel>Eye Irritation</classLabel>
<newAxiom>'Eye Irritation' SubClassOf 'Eye Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187287</classIRI>
<classLabel>Corneal Thinning</classLabel>
<newAxiom>'Corneal Thinning' SubClassOf 'Eye Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187280</classIRI>
<classLabel>Choroidal Hemorrhage</classLabel>
<newAxiom>'Choroidal Hemorrhage' SubClassOf 'Choroid Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187281</classIRI>
<classLabel>Optic Nerve Sheath Hemorrhage</classLabel>
<newAxiom>'Optic Nerve Sheath Hemorrhage' SubClassOf 'Eye Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187284</classIRI>
<classLabel>Thyroid Gland Tumor of Uncertain Malignant Potential</classLabel>
<newAxiom>'Thyroid Gland Tumor of Uncertain Malignant Potential' EquivalentTo 'Low Risk Thyroid Gland Neoplasm' and 'Neoplasm of Uncertain Malignant Potential' and ('Disease_Has_Finding' some 'Questionable Invasive Lesion') and ('Disease_Has_Finding' some 'Follicular Cell Differentiation') and ('Disease_Has_Finding' some 'Follicular Structures Present') and ('Disease_May_Have_Finding' some 'Encapsulated Mass') and ('Disease_May_Have_Molecular_Abnormality' some 'KRAS Gene Mutation') and ('Disease_May_Have_Molecular_Abnormality' some 'NRAS Gene Mutation') and ('Disease_May_Have_Molecular_Abnormality' some 'HRAS Gene Mutation')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187285</classIRI>
<classLabel>Pan-AKT Inhibitor LY2503029</classLabel>
<newAxiom>'Pan-AKT Inhibitor LY2503029' SubClassOf 'AKT Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187282</classIRI>
<classLabel>Endoleak</classLabel>
<newAxiom>'Endoleak' SubClassOf 'Aneurysm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187283</classIRI>
<classLabel>Upper Respiratory Tract Injury</classLabel>
<newAxiom>'Upper Respiratory Tract Injury' SubClassOf 'Injury'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187277</classIRI>
<classLabel>GLIS Gene Rearrangement</classLabel>
<newAxiom>'GLIS Gene Rearrangement' SubClassOf 'Gene Rearrangement Abnormality'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187278</classIRI>
<classLabel>Reduced Blood Flow</classLabel>
<newAxiom>'Reduced Blood Flow' SubClassOf 'Cardiovascular System Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187275</classIRI>
<classLabel>Abnormal Blood Protein</classLabel>
<newAxiom>'Abnormal Blood Protein' SubClassOf 'Abnormal Blood Chemistry and Hematology Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187276</classIRI>
<classLabel>Expanding Aneurysm</classLabel>
<newAxiom>'Expanding Aneurysm' SubClassOf 'Aneurysm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187279</classIRI>
<classLabel>Retinal Hemorrhage</classLabel>
<newAxiom>'Retinal Hemorrhage' SubClassOf 'Retinal Vascular Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187390</classIRI>
<classLabel>TRMT6 Gene</classLabel>
<newAxiom>'TRMT6 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'RNA Synthesis'</newAxiom>
<newAxiom>'TRMT6 Gene' SubClassOf 'Translation Process Gene'</newAxiom>
<newAxiom>'TRMT6 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Post-Transcriptional Regulation'</newAxiom>
<newAxiom>'TRMT6 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Methylation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187391</classIRI>
<classLabel>TRMT6 wt Allele</classLabel>
<newAxiom>'TRMT6 wt Allele' SubClassOf 'TRMT6 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187394</classIRI>
<classLabel>Locally Advanced Unresectable Fallopian Tube Carcinoma</classLabel>
<newAxiom>'Locally Advanced Unresectable Fallopian Tube Carcinoma' EquivalentTo 'Locally Advanced Unresectable Carcinoma' and 'Locally Advanced Fallopian Tube Carcinoma' and 'Unresectable Fallopian Tube Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187395</classIRI>
<classLabel>TRMT61A Gene</classLabel>
<newAxiom>'TRMT61A Gene' SubClassOf 'Translation Process Gene'</newAxiom>
<newAxiom>'TRMT61A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'RNA Synthesis'</newAxiom>
<newAxiom>'TRMT61A Gene' SubClassOf 'Methyltransferase Gene'</newAxiom>
<newAxiom>'TRMT61A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Post-Transcriptional Regulation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187392</classIRI>
<classLabel>tRNA (Adenine(58)-N(1))-Methyltransferase Non-Catalytic Subunit TRM6</classLabel>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Non-Catalytic Subunit TRM6' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'TRMT6 Gene'</newAxiom>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Non-Catalytic Subunit TRM6' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Methylation'</newAxiom>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Non-Catalytic Subunit TRM6' SubClassOf 'Translation Process Protein'</newAxiom>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Non-Catalytic Subunit TRM6' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'RNA Synthesis'</newAxiom>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Non-Catalytic Subunit TRM6' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Post-Transcriptional Regulation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187393</classIRI>
<classLabel>Locally Advanced Unresectable Ovarian High Grade Serous Adenocarcinoma</classLabel>
<newAxiom>'Locally Advanced Unresectable Ovarian High Grade Serous Adenocarcinoma' EquivalentTo 'Locally Advanced Unresectable Carcinoma' and 'Unresectable Ovarian High Grade Serous Adenocarcinoma' and 'Metastatic Ovarian High Grade Serous Adenocarcinoma' and 'Locally Advanced Ovarian Serous Adenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187387</classIRI>
<classLabel>CDK19 wt Allele</classLabel>
<newAxiom>'CDK19 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '6q21'</newAxiom>
<newAxiom>'CDK19 wt Allele' SubClassOf 'CDK19 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187388</classIRI>
<classLabel>Cyclin-Dependent Kinase 19</classLabel>
<newAxiom>'Cyclin-Dependent Kinase 19' EquivalentTo 'Cyclin-Dependent Kinase' and 'Transcription Regulatory Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleus') and ('Gene_Product_Is_Physical_Part_Of' some 'Mediator Complex') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Regulation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Serine/Threonine Phosphorylation') and ('Gene_Product_Encoded_By_Gene' some 'CDK19 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187385</classIRI>
<classLabel>TEAD Transcription Factor Family</classLabel>
<newAxiom>'TEAD Transcription Factor Family' SubClassOf 'Gene_Product_Has_Biochemical_Function' some 'Transcription Factor'</newAxiom>
<newAxiom>'TEAD Transcription Factor Family' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Regulation'</newAxiom>
<newAxiom>'TEAD Transcription Factor Family' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'TEAD Transcription Factor Family' SubClassOf 'Protein Family'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187386</classIRI>
<classLabel>CDK19 Gene</classLabel>
<newAxiom>'CDK19 Gene' SubClassOf 'Cyclin-Dependent Kinase Gene'</newAxiom>
<newAxiom>'CDK19 Gene' SubClassOf 'Mediator Complex Component Gene'</newAxiom>
<newAxiom>'CDK19 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Serine/Threonine Phosphorylation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187389</classIRI>
<classLabel>Locally Advanced Unresectable Primary Peritoneal Carcinoma</classLabel>
<newAxiom>'Locally Advanced Unresectable Primary Peritoneal Carcinoma' EquivalentTo 'Locally Advanced Unresectable Carcinoma' and 'Locally Advanced Primary Peritoneal Carcinoma' and 'Unresectable Primary Peritoneal Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187380</classIRI>
<classLabel>High Metal Ion Levels</classLabel>
<newAxiom>'High Metal Ion Levels' SubClassOf 'Poisoning'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187383</classIRI>
<classLabel>NOX1 wt Allele</classLabel>
<newAxiom>'NOX1 wt Allele' EquivalentTo 'NOX1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Alzheimer's Disease Pathway KEGG') and ('Gene_In_Chromosomal_Location' some 'Xq22.1')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187384</classIRI>
<classLabel>NADPH Oxidase 1</classLabel>
<newAxiom>'NADPH Oxidase 1' EquivalentTo 'Oxidoreductase' and ('Gene_Product_Is_Element_In_Pathway' some 'Alzheimer's Disease Pathway KEGG') and ('Gene_Product_Has_Chemical_Classification' some 'Transmembrane Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane') and ('Gene_Product_Has_Associated_Anatomy' some 'Early Endosome') and ('Gene_Product_Has_Associated_Anatomy' some 'Membrane of the Endosome') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Transmembrane Domain') and ('Gene_Product_Is_Physical_Part_Of' some 'NADPH Oxidase Complex') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Free Radical Formation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Ion Transport Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Regulatory Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Ligand-Independent Ion Channel Activation') and ('Gene_Product_Encoded_By_Gene' some 'NOX1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187381</classIRI>
<classLabel>Radiolucent Lines</classLabel>
<newAxiom>'Radiolucent Lines' SubClassOf 'Radiologic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187382</classIRI>
<classLabel>NOX1 Gene</classLabel>
<newAxiom>'NOX1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Ion Transport Process'</newAxiom>
<newAxiom>'NOX1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Free Radical Formation'</newAxiom>
<newAxiom>'NOX1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Ligand-Independent Ion Channel Activation'</newAxiom>
<newAxiom>'NOX1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'NOX1 Gene' SubClassOf 'Oxidoreductase Gene'</newAxiom>
<newAxiom>'NOX1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Regulatory Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187376</classIRI>
<classLabel>Inadequate Treatment/Disease Progression</classLabel>
<newAxiom>'Inadequate Treatment/Disease Progression' SubClassOf 'Treatment Status'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187377</classIRI>
<classLabel>Exposure to Contaminated Device/Risk of Infection</classLabel>
<newAxiom>'Exposure to Contaminated Device/Risk of Infection' SubClassOf 'Treatment Status'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187374</classIRI>
<classLabel>Platinum-Sensitive Endometrial Serous Adenocarcinoma</classLabel>
<newAxiom>'Platinum-Sensitive Endometrial Serous Adenocarcinoma' EquivalentTo 'Endometrial Serous Adenocarcinoma' and ('Disease_Has_Finding' some 'Platinum-Sensitive Disease') and ('Disease_Excludes_Finding' some 'Platinum-Resistant Disease')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187375</classIRI>
<classLabel>c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084</classLabel>
<newAxiom>'c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084' SubClassOf 'TRK Inhibitor'</newAxiom>
<newAxiom>'c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084' SubClassOf 'c-Met Inhibitor'</newAxiom>
<newAxiom>'c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084' SubClassOf 'FLT3 Inhibitor'</newAxiom>
<newAxiom>'c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084' SubClassOf 'Cyclin-Dependent Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187378</classIRI>
<classLabel>Insufficient Information to Classify Device</classLabel>
<newAxiom>'Insufficient Information to Classify Device' SubClassOf 'Insufficient Information Available'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187379</classIRI>
<classLabel>PD-L1 Expression Less than or Equal to 50 Percent</classLabel>
<newAxiom>'PD-L1 Expression Less than or Equal to 50 Percent' SubClassOf 'Immunohistochemical Status of PD-L1'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187372</classIRI>
<classLabel>Anti-mesothelin CAR Vector-transduced T-lymphocytes</classLabel>
<newAxiom>'Anti-mesothelin CAR Vector-transduced T-lymphocytes' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Anti-mesothelin CAR Vector-transduced T-lymphocytes' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187373</classIRI>
<classLabel>Peri-prosthetic Joint Infection</classLabel>
<newAxiom>'Peri-prosthetic Joint Infection' SubClassOf 'Joint Infection'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187370</classIRI>
<classLabel>Limb Pain</classLabel>
<newAxiom>'Limb Pain' SubClassOf 'Pain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187371</classIRI>
<classLabel>Injection Site Pooling</classLabel>
<newAxiom>'Injection Site Pooling' SubClassOf 'Integumentary System Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187365</classIRI>
<classLabel>TEAD Inhibitor IK-930</classLabel>
<newAxiom>'TEAD Inhibitor IK-930' SubClassOf 'Antineoplastic Protein Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187366</classIRI>
<classLabel>Breast Feeding Problem</classLabel>
<newAxiom>'Breast Feeding Problem' SubClassOf 'Feeding Problem'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187363</classIRI>
<classLabel>Fecal Urgency</classLabel>
<newAxiom>'Fecal Urgency' SubClassOf 'Incontinence'</newAxiom>
<newAxiom>'Fecal Urgency' SubClassOf 'Disturbance in Bowel Function'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187364</classIRI>
<classLabel>Biliary Leak</classLabel>
<newAxiom>'Biliary Leak' SubClassOf 'Digestive System Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187369</classIRI>
<classLabel>Joint Impingement</classLabel>
<newAxiom>'Joint Impingement' SubClassOf 'Musculoskeletal Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187367</classIRI>
<classLabel>Blood Bicarbonate Increased</classLabel>
<newAxiom>'Blood Bicarbonate Increased' SubClassOf 'Abnormal Blood Chemistry and Hematology Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187368</classIRI>
<classLabel>Tooth Loss</classLabel>
<newAxiom>'Tooth Loss' SubClassOf 'Oral Cavity Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187361</classIRI>
<classLabel>Posterior Capsule Opacification</classLabel>
<newAxiom>'Posterior Capsule Opacification' SubClassOf 'Eye Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187362</classIRI>
<classLabel>YAP1 or WWTR1 Fusion Gene Positive</classLabel>
<newAxiom>'YAP1 or WWTR1 Fusion Gene Positive' SubClassOf 'Genetic Fusion Positive'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187360</classIRI>
<classLabel>Corneal Endothelial Cell Loss</classLabel>
<newAxiom>'Corneal Endothelial Cell Loss' SubClassOf 'Eye Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187354</classIRI>
<classLabel>Myasthenia Gravis Foundation of America Class IIB</classLabel>
<newAxiom>'Myasthenia Gravis Foundation of America Class IIB' SubClassOf 'Myasthenia Gravis Foundation of America Class II'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187355</classIRI>
<classLabel>Myasthenia Gravis Foundation of America Class IIIA</classLabel>
<newAxiom>'Myasthenia Gravis Foundation of America Class IIIA' SubClassOf 'Myasthenia Gravis Foundation of America Class III'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187352</classIRI>
<classLabel>Myasthenia Gravis Foundation of America Class</classLabel>
<newAxiom>'Myasthenia Gravis Foundation of America Class' SubClassOf 'Nervous System Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187353</classIRI>
<classLabel>Myasthenia Gravis Foundation of America Class IIA</classLabel>
<newAxiom>'Myasthenia Gravis Foundation of America Class IIA' SubClassOf 'Myasthenia Gravis Foundation of America Class II'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187358</classIRI>
<classLabel>Myasthenia Gravis Foundation of America Class IVB</classLabel>
<newAxiom>'Myasthenia Gravis Foundation of America Class IVB' SubClassOf 'Myasthenia Gravis Foundation of America Class IV'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187359</classIRI>
<classLabel>IL-2 Superkine-Recombinant Human Albumin Fusion Protein MDNA11</classLabel>
<newAxiom>'IL-2 Superkine-Recombinant Human Albumin Fusion Protein MDNA11' SubClassOf 'Recombinant Interleukin-2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187356</classIRI>
<classLabel>Myasthenia Gravis Foundation of America Class IIIB</classLabel>
<newAxiom>'Myasthenia Gravis Foundation of America Class IIIB' SubClassOf 'Myasthenia Gravis Foundation of America Class III'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187357</classIRI>
<classLabel>Myasthenia Gravis Foundation of America Class IVA</classLabel>
<newAxiom>'Myasthenia Gravis Foundation of America Class IVA' SubClassOf 'Myasthenia Gravis Foundation of America Class IV'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187350</classIRI>
<classLabel>Mutant-selective PI3K-alpha Inhibitor BPI-21668</classLabel>
<newAxiom>'Mutant-selective PI3K-alpha Inhibitor BPI-21668' SubClassOf 'Phosphatidylinositide 3-Kinase Inhibitor'</newAxiom>
<newAxiom>'Mutant-selective PI3K-alpha Inhibitor BPI-21668' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187351</classIRI>
<classLabel>Personalized Neoantigen Vaccine NECVAX NEO1</classLabel>
<newAxiom>'Personalized Neoantigen Vaccine NECVAX NEO1' SubClassOf 'Antineoplastic Vaccine'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187343</classIRI>
<classLabel>Ocimum sanctum Extract-based Oral Spray</classLabel>
<newAxiom>'Ocimum sanctum Extract-based Oral Spray' SubClassOf 'Protective Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187344</classIRI>
<classLabel>Anti-EGFR/c-MET/c-MET Trispecific Antibody GB263T</classLabel>
<newAxiom>'Anti-EGFR/c-MET/c-MET Trispecific Antibody GB263T' SubClassOf 'Bispecific Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187341</classIRI>
<classLabel>Locally Advanced Digestive System Neuroendocrine Tumor G2</classLabel>
<newAxiom>'Locally Advanced Digestive System Neuroendocrine Tumor G2' EquivalentTo 'Locally Advanced Well Differentiated Neuroendocrine Neoplasm' and 'Locally Advanced Digestive System Neuroendocrine Neoplasm' and 'Metastatic Digestive System Neuroendocrine Tumor G2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187342</classIRI>
<classLabel>D-Chiro-inositol and Alpha-lactalbumin Supplement</classLabel>
<newAxiom>'D-Chiro-inositol and Alpha-lactalbumin Supplement' SubClassOf 'Dietary Supplement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187347</classIRI>
<classLabel>Anti-CLDN6/CD3 BiTE Antibody AMG 794</classLabel>
<newAxiom>'Anti-CLDN6/CD3 BiTE Antibody AMG 794' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-CLDN6/CD3 BiTE Antibody AMG 794' SubClassOf 'Immune Checkpoint Inhibitor'</newAxiom>
<newAxiom>'Anti-CLDN6/CD3 BiTE Antibody AMG 794' SubClassOf 'Bispecific Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187348</classIRI>
<classLabel>Pegylated TOP1 Inhibitor PEEL-224</classLabel>
<newAxiom>'Pegylated TOP1 Inhibitor PEEL-224' SubClassOf 'Camptothecin Analogue'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187345</classIRI>
<classLabel>Unresectable Digestive System Neuroendocrine Tumor G2</classLabel>
<newAxiom>'Unresectable Digestive System Neuroendocrine Tumor G2' EquivalentTo 'Unresectable Well Differentiated Neuroendocrine Neoplasm' and 'Unresectable Digestive System Neuroendocrine Neoplasm' and 'Digestive System Neuroendocrine Tumor G2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187346</classIRI>
<classLabel>KRAS G12C Inhibitor BPI-421286</classLabel>
<newAxiom>'KRAS G12C Inhibitor BPI-421286' SubClassOf 'Ras Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187349</classIRI>
<classLabel>Cereblon Modulator BTX-1188</classLabel>
<newAxiom>'Cereblon Modulator BTX-1188' SubClassOf 'Immunotherapeutic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187340</classIRI>
<classLabel>Anti-c-Met Antibody-drug Conjugate BYON3521</classLabel>
<newAxiom>'Anti-c-Met Antibody-drug Conjugate BYON3521' SubClassOf 'c-Met-targeting Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187332</classIRI>
<classLabel>Locally Advanced Digestive System Neuroendocrine Tumor G1</classLabel>
<newAxiom>'Locally Advanced Digestive System Neuroendocrine Tumor G1' EquivalentTo 'Metastatic Digestive System Neuroendocrine Tumor G1' and 'Locally Advanced Digestive System Neuroendocrine Neoplasm' and 'Locally Advanced Carcinoid Tumor' and ('Disease_Excludes_Finding' some 'Localized Disease')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187333</classIRI>
<classLabel>Anti-TROP2 Antibody-drug Conjugate BL-M02D1</classLabel>
<newAxiom>'Anti-TROP2 Antibody-drug Conjugate BL-M02D1' SubClassOf 'Immunoconjugate'</newAxiom>
<newAxiom>'Anti-TROP2 Antibody-drug Conjugate BL-M02D1' SubClassOf 'Antineoplastic Antibody-Drug Conjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187330</classIRI>
<classLabel>Autologous BAFF-expressing CAR T Cells LMY-920</classLabel>
<newAxiom>'Autologous BAFF-expressing CAR T Cells LMY-920' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Autologous BAFF-expressing CAR T Cells LMY-920' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
<newAxiom>'Autologous BAFF-expressing CAR T Cells LMY-920' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187331</classIRI>
<classLabel>Autologous HBV-specific TCR-expressing T-lymphocytes SCG101</classLabel>
<newAxiom>'Autologous HBV-specific TCR-expressing T-lymphocytes SCG101' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
<newAxiom>'Autologous HBV-specific TCR-expressing T-lymphocytes SCG101' SubClassOf 'T-cell Receptor-engineered T-cells'</newAxiom>
<newAxiom>'Autologous HBV-specific TCR-expressing T-lymphocytes SCG101' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187336</classIRI>
<classLabel>Bcl-2 Inhibitor ABBV-453</classLabel>
<newAxiom>'Bcl-2 Inhibitor ABBV-453' SubClassOf 'BCL-2 Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187337</classIRI>
<classLabel>Anti-EGFR/Anti-B7-H3 CAR-T Cells</classLabel>
<newAxiom>'Anti-EGFR/Anti-B7-H3 CAR-T Cells' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Anti-EGFR/Anti-B7-H3 CAR-T Cells' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187334</classIRI>
<classLabel>EGFR/HER2 Inhibitor ORIC-114</classLabel>
<newAxiom>'EGFR/HER2 Inhibitor ORIC-114' SubClassOf 'HER2 Inhibitor'</newAxiom>
<newAxiom>'EGFR/HER2 Inhibitor ORIC-114' SubClassOf 'Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187335</classIRI>
<classLabel>Mutant-selective PI3K-alpha H1047R Inhibitor LOXO-783</classLabel>
<newAxiom>'Mutant-selective PI3K-alpha H1047R Inhibitor LOXO-783' SubClassOf 'Phosphatidylinositide 3-Kinase Inhibitor'</newAxiom>
<newAxiom>'Mutant-selective PI3K-alpha H1047R Inhibitor LOXO-783' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187338</classIRI>
<classLabel>PD-L1 Inhibitor BPI-371153</classLabel>
<newAxiom>'PD-L1 Inhibitor BPI-371153' SubClassOf 'PD-1 Ligand Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187339</classIRI>
<classLabel>Commensal Bacterial Strain Formulation BMC128</classLabel>
<newAxiom>'Commensal Bacterial Strain Formulation BMC128' SubClassOf 'Immunotherapeutic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187321</classIRI>
<classLabel>Difficulty Chewing Food Due to Dryness of Mouth</classLabel>
<newAxiom>'Difficulty Chewing Food Due to Dryness of Mouth' SubClassOf 'Ability Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187322</classIRI>
<classLabel>Difficulty Swallowing Food Due to Dryness of Mouth</classLabel>
<newAxiom>'Difficulty Swallowing Food Due to Dryness of Mouth' SubClassOf 'Ability Question'</newAxiom>
<newAxiom>'Difficulty Swallowing Food Due to Dryness of Mouth' SubClassOf 'Swallow Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187325</classIRI>
<classLabel>Dryness of Mouth When Not Eating or Chewing</classLabel>
<newAxiom>'Dryness of Mouth When Not Eating or Chewing' SubClassOf 'Physical Feelings Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187326</classIRI>
<classLabel>Frequency of Sipping Liquids to Aid Swallowing Food Due to Dryness of Mouth</classLabel>
<newAxiom>'Frequency of Sipping Liquids to Aid Swallowing Food Due to Dryness of Mouth' SubClassOf 'Frequency Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187323</classIRI>
<classLabel>ATR Inhibitor ATG-018</classLabel>
<newAxiom>'ATR Inhibitor ATG-018' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'ATR Inhibitor ATG-018' SubClassOf 'ATR Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187324</classIRI>
<classLabel>Dryness of Mouth when Eating a Meal</classLabel>
<newAxiom>'Dryness of Mouth when Eating a Meal' SubClassOf 'Physical Feelings Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187329</classIRI>
<classLabel>Frequency of Sleeping Problems Due to Dryness of Mouth</classLabel>
<newAxiom>'Frequency of Sleeping Problems Due to Dryness of Mouth' SubClassOf 'Frequency Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187327</classIRI>
<classLabel>Frequency of Fluid Intake Required for Oral Comfort When Not Eating Due to Dryness of Mouth</classLabel>
<newAxiom>'Frequency of Fluid Intake Required for Oral Comfort When Not Eating Due to Dryness of Mouth' SubClassOf 'Frequency Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187328</classIRI>
<classLabel>Locally Advanced Carcinoid Tumor</classLabel>
<newAxiom>'Locally Advanced Carcinoid Tumor' EquivalentTo 'Locally Advanced Well Differentiated Neuroendocrine Neoplasm' and 'Metastatic Carcinoid Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187310</classIRI>
<classLabel>Able to Pay for Daily Food Expenses</classLabel>
<newAxiom>'Able to Pay for Daily Food Expenses' SubClassOf 'Financial Question'</newAxiom>
<newAxiom>'Able to Pay for Daily Food Expenses' SubClassOf 'Ability Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187311</classIRI>
<classLabel>Able to Pay for Daily Housing Expenses</classLabel>
<newAxiom>'Able to Pay for Daily Housing Expenses' SubClassOf 'Financial Question'</newAxiom>
<newAxiom>'Able to Pay for Daily Housing Expenses' SubClassOf 'Ability Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187314</classIRI>
<classLabel>Have to Borrow Money to Help with Treatment-Related Expenses</classLabel>
<newAxiom>'Have to Borrow Money to Help with Treatment-Related Expenses' SubClassOf 'Treatment Question'</newAxiom>
<newAxiom>'Have to Borrow Money to Help with Treatment-Related Expenses' SubClassOf 'Financial Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187315</classIRI>
<classLabel>Had to Permanently Quit Previous Occupation Because of Cancer Diagnosis and/or Treatment</classLabel>
<newAxiom>'Had to Permanently Quit Previous Occupation Because of Cancer Diagnosis and/or Treatment' SubClassOf 'Work Question'</newAxiom>
<newAxiom>'Had to Permanently Quit Previous Occupation Because of Cancer Diagnosis and/or Treatment' SubClassOf 'Treatment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187312</classIRI>
<classLabel>Able to Pay for Medications Related to My Treatment</classLabel>
<newAxiom>'Able to Pay for Medications Related to My Treatment' SubClassOf 'Treatment Question'</newAxiom>
<newAxiom>'Able to Pay for Medications Related to My Treatment' SubClassOf 'Financial Question'</newAxiom>
<newAxiom>'Able to Pay for Medications Related to My Treatment' SubClassOf 'Ability Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187313</classIRI>
<classLabel>Anti-TROP2 Antibody-drug Conjugate BIO-106</classLabel>
<newAxiom>'Anti-TROP2 Antibody-drug Conjugate BIO-106' SubClassOf 'Immunoconjugate'</newAxiom>
<newAxiom>'Anti-TROP2 Antibody-drug Conjugate BIO-106' SubClassOf 'Antineoplastic Antibody-Drug Conjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187318</classIRI>
<classLabel>My Family or Friends Had to Permanently Quit Their Job to Help with My Care Needs Because of My Cancer Diagnosis or Treatment</classLabel>
<newAxiom>'My Family or Friends Had to Permanently Quit Their Job to Help with My Care Needs Because of My Cancer Diagnosis or Treatment' SubClassOf 'Treatment Question'</newAxiom>
<newAxiom>'My Family or Friends Had to Permanently Quit Their Job to Help with My Care Needs Because of My Cancer Diagnosis or Treatment' SubClassOf 'Work Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187319</classIRI>
<classLabel>Difficulty Speaking Due to Dryness of Mouth and Tongue</classLabel>
<newAxiom>'Difficulty Speaking Due to Dryness of Mouth and Tongue' SubClassOf 'Ability Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187316</classIRI>
<classLabel>Advanced Malignant Testicular Germ Cell Tumor</classLabel>
<newAxiom>'Advanced Malignant Testicular Germ Cell Tumor' EquivalentTo 'Advanced Malignant Germ Cell Tumor' and 'Advanced Malignant Genitourinary System Neoplasm' and 'Metastatic Malignant Testicular Germ Cell Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187317</classIRI>
<classLabel>Autologous GCC-targeting CAR T Cells GCC19CART</classLabel>
<newAxiom>'Autologous GCC-targeting CAR T Cells GCC19CART' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Autologous GCC-targeting CAR T Cells GCC19CART' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Autologous GCC-targeting CAR T Cells GCC19CART' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187398</classIRI>
<classLabel>Locally Advanced Unresectable HER2-Negative Breast Carcinoma</classLabel>
<newAxiom>'Locally Advanced Unresectable HER2-Negative Breast Carcinoma' EquivalentTo 'Locally Advanced Unresectable Breast Carcinoma' and 'Locally Advanced HER2-Negative Breast Carcinoma' and 'Unresectable HER2-Negative Breast Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187399</classIRI>
<classLabel>Locally Advanced Hormone Receptor-Positive Breast Carcinoma</classLabel>
<newAxiom>'Locally Advanced Hormone Receptor-Positive Breast Carcinoma' EquivalentTo 'Locally Advanced Breast Adenocarcinoma' and 'Metastatic Hormone Receptor-Positive Breast Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187396</classIRI>
<classLabel>TRMT61A wt Allele</classLabel>
<newAxiom>'TRMT61A wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '14q32.33'</newAxiom>
<newAxiom>'TRMT61A wt Allele' SubClassOf 'TRMT61A Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187397</classIRI>
<classLabel>tRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A</classLabel>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'RNA Synthesis'</newAxiom>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A' SubClassOf 'Translation Process Protein'</newAxiom>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Post-Transcriptional Regulation'</newAxiom>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A' SubClassOf 'Methyltransferase'</newAxiom>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A' SubClassOf 'Gene_Product_Has_Biochemical_Function' some 'tRNA Methyltransferase'</newAxiom>
<newAxiom>'tRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'TRMT61A Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187300</classIRI>
<classLabel>Anti-CD19 CAR T Cells AT101</classLabel>
<newAxiom>'Anti-CD19 CAR T Cells AT101' SubClassOf 'Anti-CD19-targeting CAR-T Cells'</newAxiom>
<newAxiom>'Anti-CD19 CAR T Cells AT101' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187303</classIRI>
<classLabel>Satisfied with Family's Financial Situation</classLabel>
<newAxiom>'Satisfied with Family's Financial Situation' SubClassOf 'Satisfaction Question'</newAxiom>
<newAxiom>'Satisfied with Family's Financial Situation' SubClassOf 'Financial Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187304</classIRI>
<classLabel>R-1,3-Butanediol-based Supplement</classLabel>
<newAxiom>'R-1,3-Butanediol-based Supplement' SubClassOf 'Dietary Supplement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187301</classIRI>
<classLabel>Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101</classLabel>
<newAxiom>'Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187302</classIRI>
<classLabel>Personalized Liposomal Neoantigen-based Peptide Vaccine EVX-01</classLabel>
<newAxiom>'Personalized Liposomal Neoantigen-based Peptide Vaccine EVX-01' SubClassOf 'Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue' some 'Cytotoxic T-Lymphocyte'</newAxiom>
<newAxiom>'Personalized Liposomal Neoantigen-based Peptide Vaccine EVX-01' SubClassOf 'Chemical_Or_Drug_Has_Mechanism_Of_Action' some 'Antigen Sensitization'</newAxiom>
<newAxiom>'Personalized Liposomal Neoantigen-based Peptide Vaccine EVX-01' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'T-Cell Activation'</newAxiom>
<newAxiom>'Personalized Liposomal Neoantigen-based Peptide Vaccine EVX-01' SubClassOf 'Chemical_Or_Drug_Has_Physiologic_Effect' some 'Immunopotentiation'</newAxiom>
<newAxiom>'Personalized Liposomal Neoantigen-based Peptide Vaccine EVX-01' SubClassOf 'Antineoplastic Vaccine'</newAxiom>
<newAxiom>'Personalized Liposomal Neoantigen-based Peptide Vaccine EVX-01' SubClassOf 'Peptide Vaccine'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187307</classIRI>
<classLabel>Perception of Family's Financial Situation Compared to Others of Same Age</classLabel>
<newAxiom>'Perception of Family's Financial Situation Compared to Others of Same Age' SubClassOf 'Financial Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187308</classIRI>
<classLabel>HSD-1 Inhibitor SPI-62</classLabel>
<newAxiom>'HSD-1 Inhibitor SPI-62' SubClassOf 'Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187305</classIRI>
<classLabel>Worried About Family's Financial Situation</classLabel>
<newAxiom>'Worried About Family's Financial Situation' SubClassOf 'Financial Question'</newAxiom>
<newAxiom>'Worried About Family's Financial Situation' SubClassOf 'Worry Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187306</classIRI>
<classLabel>Financial Question</classLabel>
<newAxiom>'Financial Question' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187309</classIRI>
<classLabel>Pelvic Fascia-Sparing Radical Prostatectomy</classLabel>
<newAxiom>'Pelvic Fascia-Sparing Radical Prostatectomy' SubClassOf 'Laparoscopic Radical Prostatectomy with Robotics'</newAxiom>
<newAxiom>'Pelvic Fascia-Sparing Radical Prostatectomy' SubClassOf 'Nerve-Sparing Prostatectomy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187099</classIRI>
<classLabel>Immature PIT1 Lineage Pituitary Neuroendocrine Tumor</classLabel>
<newAxiom>'Immature PIT1 Lineage Pituitary Neuroendocrine Tumor' EquivalentTo 'Pituitary Neuroendocrine Tumor of PIT1-Lineage' and 'Atypical Adenoma' and ('Disease_Has_Normal_Cell_Origin' some 'Chromophobe Cell') and ('Disease_Has_Finding' some 'Marked Nuclear Atypia Present')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187090</classIRI>
<classLabel>TBX19 wt Allele</classLabel>
<newAxiom>'TBX19 wt Allele' SubClassOf 'TBX19 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187093</classIRI>
<classLabel>ENPP1 wt Allele</classLabel>
<newAxiom>'ENPP1 wt Allele' EquivalentTo 'ENPP1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Nicotinate and Nicotinamide Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Pantothenate and CoA Biosynthesis Pathway') and ('Gene_Is_Element_In_Pathway' some 'Purine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Pyrimidine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Riboflavin Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Starch and Sucrose Metabolism Pathway')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187094</classIRI>
<classLabel>Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1</classLabel>
<newAxiom>'Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1' EquivalentTo 'Esterase' and ('Gene_Product_Is_Element_In_Pathway' some 'Nicotinate and Nicotinamide Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Pantothenate and CoA Biosynthesis Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Purine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Pyrimidine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Riboflavin Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Starch and Sucrose Metabolism Pathway') and ('Gene_Product_Has_Chemical_Classification' some 'Transmembrane Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Transmembrane Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Metal Binding Site') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Nucleotide Metabolic Process') and ('Gene_Product_Encoded_By_Gene' some 'ENPP1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187091</classIRI>
<classLabel>T-Box Transcription Factor TBX19</classLabel>
<newAxiom>'T-Box Transcription Factor TBX19' EquivalentTo 'Transcription Factor' and ('Gene_Product_Has_Chemical_Classification' some 'Sequence-Specific DNA Binding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'DNA Binding') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Regulation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Developmental Process') and ('Gene_Product_Encoded_By_Gene' some 'TBX19 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187092</classIRI>
<classLabel>ENPP1 Gene</classLabel>
<newAxiom>'ENPP1 Gene' SubClassOf 'Esterase Gene'</newAxiom>
<newAxiom>'ENPP1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Melanogenesis'</newAxiom>
<newAxiom>'ENPP1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Nucleotide Metabolic Process'</newAxiom>
<newAxiom>'ENPP1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Mineralization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187097</classIRI>
<classLabel>No Evidence of Distinct Lineage Differentiation Present</classLabel>
<newAxiom>'No Evidence of Distinct Lineage Differentiation Present' SubClassOf 'Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187098</classIRI>
<classLabel>Mature Plurihormonal PIT1 Lineage Pituitary Neuroendocrine Tumor</classLabel>
<newAxiom>'Mature Plurihormonal PIT1 Lineage Pituitary Neuroendocrine Tumor' EquivalentTo 'Pituitary Neuroendocrine Tumor of PIT1-Lineage' and ('Disease_Has_Normal_Cell_Origin' some 'Acidophilic Cell') and ('Disease_Has_Finding' some 'Multihormonal Immunoreactivity Present')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187095</classIRI>
<classLabel>Course Timing Protocol Treatment Course</classLabel>
<newAxiom>'Course Timing Protocol Treatment Course' SubClassOf 'Protocol Treatment Course'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187096</classIRI>
<classLabel>Pituitary Neuroendocrine Tumor without Distinct Lineage Differentiation</classLabel>
<newAxiom>'Pituitary Neuroendocrine Tumor without Distinct Lineage Differentiation' EquivalentTo 'Pituitary Neuroendocrine Tumor' and ('Disease_Has_Finding' some 'No Evidence of Distinct Lineage Differentiation Present')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187088</classIRI>
<classLabel>Pituitary Neuroendocrine Tumor of SF1-Lineage</classLabel>
<newAxiom>'Pituitary Neuroendocrine Tumor of SF1-Lineage' EquivalentTo 'Pituitary Neuroendocrine Tumor' and ('Disease_Has_Normal_Cell_Origin' some 'SF1-Lineage Adenohypophysial Cell')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187089</classIRI>
<classLabel>TBX19 Gene</classLabel>
<newAxiom>'TBX19 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'DNA Binding'</newAxiom>
<newAxiom>'TBX19 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Developmental Process'</newAxiom>
<newAxiom>'TBX19 Gene' SubClassOf 'Transcription Factor Gene'</newAxiom>
<newAxiom>'TBX19 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Regulation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187082</classIRI>
<classLabel>Subpleural Nodule</classLabel>
<newAxiom>'Subpleural Nodule' SubClassOf 'Nodule'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187083</classIRI>
<classLabel>Nanoparticle Formulation CPI-300</classLabel>
<newAxiom>'Nanoparticle Formulation CPI-300' SubClassOf 'Enzyme Replacement or Supplement Agent'</newAxiom>
<newAxiom>'Nanoparticle Formulation CPI-300' SubClassOf 'Agent Targeting Cancer Metabolism'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187080</classIRI>
<classLabel>Paclitaxel-loaded Tumor Penetrating Microparticles</classLabel>
<newAxiom>'Paclitaxel-loaded Tumor Penetrating Microparticles' SubClassOf 'Paclitaxel Preparation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187081</classIRI>
<classLabel>Endobronchial Nodule</classLabel>
<newAxiom>'Endobronchial Nodule' SubClassOf 'Nodule'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187086</classIRI>
<classLabel>Pituitary Neuroendocrine Tumor of PIT1-Lineage</classLabel>
<newAxiom>'Pituitary Neuroendocrine Tumor of PIT1-Lineage' EquivalentTo 'Pituitary Neuroendocrine Tumor' and ('Disease_Has_Normal_Cell_Origin' some 'PIT1-Lineage Adenohypophysial Cell') and ('Disease_Mapped_To_Gene' some 'POU1F1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187087</classIRI>
<classLabel>Pituitary Neuroendocrine Tumor of TPIT-Lineage</classLabel>
<newAxiom>'Pituitary Neuroendocrine Tumor of TPIT-Lineage' EquivalentTo 'Pituitary Neuroendocrine Tumor' and ('Disease_Has_Normal_Cell_Origin' some 'TPIT-Lineage Adenohypophysial Cell') and ('Disease_Mapped_To_Gene' some 'TBX19 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187084</classIRI>
<classLabel>Complicated Parapneumonic Pleural Effusion</classLabel>
<newAxiom>'Complicated Parapneumonic Pleural Effusion' SubClassOf 'Effusion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187085</classIRI>
<classLabel>Recombinant Single-chain Urokinase Plasminogen Activator LTI-01</classLabel>
<newAxiom>'Recombinant Single-chain Urokinase Plasminogen Activator LTI-01' SubClassOf 'Enzyme Replacement or Supplement Agent'</newAxiom>
<newAxiom>'Recombinant Single-chain Urokinase Plasminogen Activator LTI-01' SubClassOf 'Agent Affecting Respiratory System'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187079</classIRI>
<classLabel>TPIT-Lineage Adenohypophysial Cell</classLabel>
<newAxiom>'TPIT-Lineage Adenohypophysial Cell' SubClassOf 'Adenohypophysial Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187077</classIRI>
<classLabel>PIT1-Lineage Adenohypophysial Cell</classLabel>
<newAxiom>'PIT1-Lineage Adenohypophysial Cell' SubClassOf 'Adenohypophysial Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187078</classIRI>
<classLabel>SF1-Lineage Adenohypophysial Cell</classLabel>
<newAxiom>'SF1-Lineage Adenohypophysial Cell' SubClassOf 'Adenohypophysial Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187071</classIRI>
<classLabel>Pre-enrollment</classLabel>
<newAxiom>'Pre-enrollment' SubClassOf 'Period'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187072</classIRI>
<classLabel>FOXO1 Fusion Negative</classLabel>
<newAxiom>'FOXO1 Fusion Negative' SubClassOf 'Rearrangement Negative'</newAxiom>
<newAxiom>'FOXO1 Fusion Negative' SubClassOf 'Expression Negative'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187070</classIRI>
<classLabel>Frozen Shipper</classLabel>
<newAxiom>'Frozen Shipper' SubClassOf 'Barrel Container'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187075</classIRI>
<classLabel>TNKS2 wt Allele</classLabel>
<newAxiom>'TNKS2 wt Allele' SubClassOf 'TNKS2 Gene'</newAxiom>
<newAxiom>'TNKS2 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Telomerase Regulation Pathway'</newAxiom>
<newAxiom>'TNKS2 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Telomere Pathway'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187076</classIRI>
<classLabel>Poly [ADP-Ribose] Polymerase Tankyrase-2</classLabel>
<newAxiom>'Poly [ADP-Ribose] Polymerase Tankyrase-2' EquivalentTo 'Glycosyltransferase' and ('Gene_Product_Is_Element_In_Pathway' some 'Telomere Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Telomerase Regulation Pathway') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'SAM Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Ankyrin Repeat') and ('Gene_Product_Has_Biochemical_Function' some 'Ubiquitination Regulation Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Poly-ADP-Ribosylation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Ubiquitination') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Telomere Maintenance') and ('Gene_Product_Encoded_By_Gene' some 'TNKS2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187073</classIRI>
<classLabel>MYOD1 Gene Mutation Negative</classLabel>
<newAxiom>'MYOD1 Gene Mutation Negative' SubClassOf 'Wildtype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187074</classIRI>
<classLabel>TNKS2 Gene</classLabel>
<newAxiom>'TNKS2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Telomere Maintenance'</newAxiom>
<newAxiom>'TNKS2 Gene' SubClassOf 'Glycosyltransferase Gene'</newAxiom>
<newAxiom>'TNKS2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Ubiquitination'</newAxiom>
<newAxiom>'TNKS2 Gene' SubClassOf 'Telomere Maintenance Gene'</newAxiom>
<newAxiom>'TNKS2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Poly-ADP-Ribosylation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187068</classIRI>
<classLabel>DHL</classLabel>
<newAxiom>'DHL' SubClassOf 'Company'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187069</classIRI>
<classLabel>Frozen on Dry Ice</classLabel>
<newAxiom>'Frozen on Dry Ice' SubClassOf 'Biospecimen Condition'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187066</classIRI>
<classLabel>United Parcel Service</classLabel>
<newAxiom>'United Parcel Service' SubClassOf 'Company'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187067</classIRI>
<classLabel>Federal Express</classLabel>
<newAxiom>'Federal Express' SubClassOf 'Company'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187060</classIRI>
<classLabel>Leukapharesis Specimen</classLabel>
<newAxiom>'Leukapharesis Specimen' SubClassOf 'Biospecimen'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187061</classIRI>
<classLabel>Lung Fluid Specimen</classLabel>
<newAxiom>'Lung Fluid Specimen' SubClassOf 'Biospecimen'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187064</classIRI>
<classLabel>Block Cassette</classLabel>
<newAxiom>'Block Cassette' SubClassOf 'Device Component or Accessory'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187065</classIRI>
<classLabel>Slide Cassette</classLabel>
<newAxiom>'Slide Cassette' SubClassOf 'Device Component or Accessory'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187062</classIRI>
<classLabel>Pericardial Fluid Specimen</classLabel>
<newAxiom>'Pericardial Fluid Specimen' SubClassOf 'Biospecimen'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187063</classIRI>
<classLabel>Buccal Swab Collection Tube</classLabel>
<newAxiom>'Buccal Swab Collection Tube' SubClassOf 'Tube Device'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187057</classIRI>
<classLabel>ORCHESTRA Terminology</classLabel>
<newAxiom>'ORCHESTRA Terminology' SubClassOf 'COVID-19 Terminology'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187058</classIRI>
<classLabel>Manifest</classLabel>
<newAxiom>'Manifest' SubClassOf 'List'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187055</classIRI>
<classLabel>Internal Surface</classLabel>
<newAxiom>'Internal Surface' SubClassOf 'Surface'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187056</classIRI>
<classLabel>Childhood Acute Leukemia</classLabel>
<newAxiom>'Childhood Acute Leukemia' EquivalentTo 'Childhood Leukemia' and 'Acute Leukemia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187059</classIRI>
<classLabel>Ready to Ship</classLabel>
<newAxiom>'Ready to Ship' SubClassOf 'Status'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187053</classIRI>
<classLabel>Upper Surface</classLabel>
<newAxiom>'Upper Surface' SubClassOf 'Surface'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187054</classIRI>
<classLabel>Outer Surface</classLabel>
<newAxiom>'Outer Surface' SubClassOf 'Surface'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187051</classIRI>
<classLabel>Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma of Unknown Primary</classLabel>
<newAxiom>'Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma of Unknown Primary' EquivalentTo 'Metastatic Human Papillomavirus-Related Malignant Neoplasm' and 'Head and Neck Carcinoma of Unknown Primary' and 'Human Papillomavirus-Related Squamous Cell Carcinoma' and 'Squamous Cell Carcinoma of Unknown Primary'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187052</classIRI>
<classLabel>Underside Surface</classLabel>
<newAxiom>'Underside Surface' SubClassOf 'Surface'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187152</classIRI>
<classLabel>ERBB2 NP_004439.2:p.L755S</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.L755S' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2264TC'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.L755S' SubClassOf 'ERBB2 NP_004439.2:p.L755X'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187153</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2263_2264delinsCC</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2263_2264delinsCC' SubClassOf 'Activating ERBB2 Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2263_2264delinsCC' SubClassOf 'ERBB2 Exon 19 Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2263_2264delinsCC' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.L755P'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187150</classIRI>
<classLabel>ERBB2 NP_004439.2:p.S653C</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.S653C' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.S653C' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.1958CG'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187151</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2264TC</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2264TC' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.L755S'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2264TC' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2264TC' SubClassOf 'ERBB2 Exon 19 Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187145</classIRI>
<classLabel>ERBB2 NM_004448.4:c.926GC</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.926GC' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.G309A'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.926GC' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187146</classIRI>
<classLabel>ERBB2 NP_004439.2:p.G309A</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.G309A' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.G309A' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.926GC'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187143</classIRI>
<classLabel>Anti-TNFR2 Monoclonal Antibody HFB200301</classLabel>
<newAxiom>'Anti-TNFR2 Monoclonal Antibody HFB200301' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-TNFR2 Monoclonal Antibody HFB200301' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187144</classIRI>
<classLabel>PSA Doubling Time Greater than 3 Months</classLabel>
<newAxiom>'PSA Doubling Time Greater than 3 Months' SubClassOf 'PSA Level Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187149</classIRI>
<classLabel>ERBB2 NM_004448.4:c.1958CG</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.1958CG' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.S653C'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.1958CG' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187147</classIRI>
<classLabel>ERBB2 NM_004448.4:c.926GA</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.926GA' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.926GA' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.G309E'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187148</classIRI>
<classLabel>ERBB2 NP_004439.2:p.G309E</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.G309E' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.926GA'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.G309E' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187141</classIRI>
<classLabel>Cytotoxic Agent-LAT1 Substrate QBS10072S</classLabel>
<newAxiom>'Cytotoxic Agent-LAT1 Substrate QBS10072S' SubClassOf 'DNA Binding Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187142</classIRI>
<classLabel>EBP Inhibitor DSP-0390</classLabel>
<newAxiom>'EBP Inhibitor DSP-0390' SubClassOf 'Antineoplastic Protein Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187140</classIRI>
<classLabel>Hyperattenuation</classLabel>
<newAxiom>'Hyperattenuation' SubClassOf 'Radiologic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187134</classIRI>
<classLabel>Capmatinib Regimen</classLabel>
<newAxiom>'Capmatinib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Capmatinib Hydrochloride'</newAxiom>
<newAxiom>'Capmatinib Regimen' SubClassOf 'Regimen Used to Treat Non-Small Cell Lung Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187135</classIRI>
<classLabel>Pituitary Neuroendocrine Tumor, Not Otherwise Specified</classLabel>
<newAxiom>'Pituitary Neuroendocrine Tumor, Not Otherwise Specified' EquivalentTo 'Pituitary Neuroendocrine Tumor' and ('Disease_Has_Finding' some 'Unclassifiable/Not Further Specified Lesion')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187132</classIRI>
<classLabel>Black Seed Oil Extract Supplement</classLabel>
<newAxiom>'Black Seed Oil Extract Supplement' SubClassOf 'Dietary Supplement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187133</classIRI>
<classLabel>Dacomitinib Regimen</classLabel>
<newAxiom>'Dacomitinib Regimen' SubClassOf 'Regimen Used to Treat Non-Small Cell Lung Carcinoma'</newAxiom>
<newAxiom>'Dacomitinib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Dacomitinib'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187138</classIRI>
<classLabel>Everolimus/Sorafenib Regimen</classLabel>
<newAxiom>'Everolimus/Sorafenib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Everolimus'</newAxiom>
<newAxiom>'Everolimus/Sorafenib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Sorafenib Tosylate'</newAxiom>
<newAxiom>'Everolimus/Sorafenib Regimen' SubClassOf 'Regimen Used to Treat Bone Cancer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187139</classIRI>
<classLabel>SDC1 Negative</classLabel>
<newAxiom>'SDC1 Negative' SubClassOf 'Expression Negative'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187136</classIRI>
<classLabel>Sotorasib Regimen</classLabel>
<newAxiom>'Sotorasib Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Sotorasib'</newAxiom>
<newAxiom>'Sotorasib Regimen' SubClassOf 'Regimen Used to Treat Non-Small Cell Lung Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187137</classIRI>
<classLabel>Sorafenib/Topotecan Regimen</classLabel>
<newAxiom>'Sorafenib/Topotecan Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Sorafenib Tosylate'</newAxiom>
<newAxiom>'Sorafenib/Topotecan Regimen' SubClassOf 'Regimen Used to Treat Malignant Peritoneal Neoplasm'</newAxiom>
<newAxiom>'Sorafenib/Topotecan Regimen' SubClassOf 'Chemotherapy_Regimen_Has_Component' some 'Topotecan Hydrochloride'</newAxiom>
<newAxiom>'Sorafenib/Topotecan Regimen' SubClassOf 'Regimen Used to Treat Malignant Ovarian Neoplasm'</newAxiom>
<newAxiom>'Sorafenib/Topotecan Regimen' SubClassOf 'Regimen Used to Treat Malignant Fallopian Tube Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187130</classIRI>
<classLabel>Allogeneic Nicotinamide-expanded Natural Killer Cells GDA-201</classLabel>
<newAxiom>'Allogeneic Nicotinamide-expanded Natural Killer Cells GDA-201' SubClassOf 'Therapeutic Allogeneic Lymphocytes'</newAxiom>
<newAxiom>'Allogeneic Nicotinamide-expanded Natural Killer Cells GDA-201' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187131</classIRI>
<classLabel>P30-linked EphA2/CMV pp65/Survivin Peptide Vaccine P30-EPS</classLabel>
<newAxiom>'P30-linked EphA2/CMV pp65/Survivin Peptide Vaccine P30-EPS' SubClassOf 'Peptide Vaccine'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187123</classIRI>
<classLabel>pan-RAF Inhibitor XP-102</classLabel>
<newAxiom>'pan-RAF Inhibitor XP-102' SubClassOf 'Raf Kinase Inhibitor'</newAxiom>
<newAxiom>'pan-RAF Inhibitor XP-102' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187124</classIRI>
<classLabel>mRNA-encoded Anti-CD3/Anti-CLDN6 Bispecific Antibody BNT142</classLabel>
<newAxiom>'mRNA-encoded Anti-CD3/Anti-CLDN6 Bispecific Antibody BNT142' SubClassOf 'Bispecific Monoclonal Antibody'</newAxiom>
<newAxiom>'mRNA-encoded Anti-CD3/Anti-CLDN6 Bispecific Antibody BNT142' SubClassOf 'Antineoplastic Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187121</classIRI>
<classLabel>Anti-B7-H3 Antibody-drug Conjugate HS-20093</classLabel>
<newAxiom>'Anti-B7-H3 Antibody-drug Conjugate HS-20093' SubClassOf 'Antineoplastic Antibody-Drug Conjugate'</newAxiom>
<newAxiom>'Anti-B7-H3 Antibody-drug Conjugate HS-20093' SubClassOf 'Immunoconjugate'</newAxiom>
<newAxiom>'Anti-B7-H3 Antibody-drug Conjugate HS-20093' SubClassOf 'cKIT-targeting Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187122</classIRI>
<classLabel>Allogeneic Dendritic Secretomes</classLabel>
<newAxiom>'Allogeneic Dendritic Secretomes' SubClassOf 'Immunostimulant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187127</classIRI>
<classLabel>ENPP1 Inhibitor RBS2418</classLabel>
<newAxiom>'ENPP1 Inhibitor RBS2418' SubClassOf 'Immunostimulant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187128</classIRI>
<classLabel>Anti-LAIR1 Monoclonal Antibody NGM438</classLabel>
<newAxiom>'Anti-LAIR1 Monoclonal Antibody NGM438' SubClassOf 'Immune Checkpoint Inhibitor'</newAxiom>
<newAxiom>'Anti-LAIR1 Monoclonal Antibody NGM438' SubClassOf 'Antineoplastic Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187125</classIRI>
<classLabel>Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321</classLabel>
<newAxiom>'Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321' SubClassOf 'Anti-BCMA-targeting CAR-T Cells'</newAxiom>
<newAxiom>'Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321' SubClassOf 'Therapeutic Allogeneic Lymphocytes'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187126</classIRI>
<classLabel>Curcumin/Polyphenols-containing Botanical Agent APG-157</classLabel>
<newAxiom>'Curcumin/Polyphenols-containing Botanical Agent APG-157' SubClassOf 'Antineoplastic Plant Product'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187129</classIRI>
<classLabel>Anti-CD19/Anti-CD20/Anti-CD22 CAR-T Cells LCAR-AIO</classLabel>
<newAxiom>'Anti-CD19/Anti-CD20/Anti-CD22 CAR-T Cells LCAR-AIO' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Anti-CD19/Anti-CD20/Anti-CD22 CAR-T Cells LCAR-AIO' SubClassOf 'Anti-CD19-targeting CAR-T Cells'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187120</classIRI>
<classLabel>Anti-HJV Monoclonal Antibody DISC-0974</classLabel>
<newAxiom>'Anti-HJV Monoclonal Antibody DISC-0974' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187112</classIRI>
<classLabel>LSD1/HDAC6 Inhibitor JBI-802</classLabel>
<newAxiom>'LSD1/HDAC6 Inhibitor JBI-802' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'LSD1/HDAC6 Inhibitor JBI-802' SubClassOf 'Histone Deacetylase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187113</classIRI>
<classLabel>ATR Inhibitor IMP9064</classLabel>
<newAxiom>'ATR Inhibitor IMP9064' SubClassOf 'ATR Inhibitor'</newAxiom>
<newAxiom>'ATR Inhibitor IMP9064' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187110</classIRI>
<classLabel>Anti-CD25-IL-2 Monoclonal Antibody AU-007</classLabel>
<newAxiom>'Anti-CD25-IL-2 Monoclonal Antibody AU-007' SubClassOf 'Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-CD25-IL-2 Monoclonal Antibody AU-007' SubClassOf 'Antineoplastic Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187111</classIRI>
<classLabel>Bi-Sialidase Fusion Protein E-602</classLabel>
<newAxiom>'Bi-Sialidase Fusion Protein E-602' SubClassOf 'Immunotherapeutic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187116</classIRI>
<classLabel>Polymeric Nanoparticle-conjugated Camptothecin DAN-222</classLabel>
<newAxiom>'Polymeric Nanoparticle-conjugated Camptothecin DAN-222' SubClassOf 'Camptothecin Analogue'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187117</classIRI>
<classLabel>Anti-BAFFR Monoclonal Antibody ESG206</classLabel>
<newAxiom>'Anti-BAFFR Monoclonal Antibody ESG206' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-BAFFR Monoclonal Antibody ESG206' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187114</classIRI>
<classLabel>RET Inhibitor KL590586</classLabel>
<newAxiom>'RET Inhibitor KL590586' SubClassOf 'RET Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187115</classIRI>
<classLabel>Mutant-selective EGFR Inhibitor BDTX-1535</classLabel>
<newAxiom>'Mutant-selective EGFR Inhibitor BDTX-1535' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'Mutant-selective EGFR Inhibitor BDTX-1535' SubClassOf 'Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187118</classIRI>
<classLabel>Autologous Anti-ROR1 CAR T-cells LYL797</classLabel>
<newAxiom>'Autologous Anti-ROR1 CAR T-cells LYL797' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
<newAxiom>'Autologous Anti-ROR1 CAR T-cells LYL797' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Autologous Anti-ROR1 CAR T-cells LYL797' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187119</classIRI>
<classLabel>PRMT5 Inhibitor TNG908</classLabel>
<newAxiom>'PRMT5 Inhibitor TNG908' SubClassOf 'PRMT5 Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187101</classIRI>
<classLabel>Anti-PD-L1/Anti-OX40 Bispecific Antibody EMB-09</classLabel>
<newAxiom>'Anti-PD-L1/Anti-OX40 Bispecific Antibody EMB-09' SubClassOf 'Bispecific Antibody'</newAxiom>
<newAxiom>'Anti-PD-L1/Anti-OX40 Bispecific Antibody EMB-09' SubClassOf 'Anti-PD-L1 Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-PD-L1/Anti-OX40 Bispecific Antibody EMB-09' SubClassOf 'Anti-OX40 Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187102</classIRI>
<classLabel>Adenosine A2A Receptor Antagonist ILB2109</classLabel>
<newAxiom>'Adenosine A2A Receptor Antagonist ILB2109' SubClassOf 'Immunostimulant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187100</classIRI>
<classLabel>BTK Inhibitor TT-01488</classLabel>
<newAxiom>'BTK Inhibitor TT-01488' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'BTK Inhibitor TT-01488' SubClassOf 'BTK Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187105</classIRI>
<classLabel>Anti-PVRIG Monoclonal Antibody GSK4381562</classLabel>
<newAxiom>'Anti-PVRIG Monoclonal Antibody GSK4381562' SubClassOf 'Immune Checkpoint Modulator'</newAxiom>
<newAxiom>'Anti-PVRIG Monoclonal Antibody GSK4381562' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187106</classIRI>
<classLabel>Anti-ROR1 Antibody-drug Conjugate CS5001</classLabel>
<newAxiom>'Anti-ROR1 Antibody-drug Conjugate CS5001' SubClassOf 'Immunoconjugate'</newAxiom>
<newAxiom>'Anti-ROR1 Antibody-drug Conjugate CS5001' SubClassOf 'Antineoplastic Antibody-Drug Conjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187103</classIRI>
<classLabel>Anti-Claudin18.2/Anti-CD3 Bispecific Antibody QLS31905</classLabel>
<newAxiom>'Anti-Claudin18.2/Anti-CD3 Bispecific Antibody QLS31905' SubClassOf 'Bispecific Antibody'</newAxiom>
<newAxiom>'Anti-Claudin18.2/Anti-CD3 Bispecific Antibody QLS31905' SubClassOf 'Anti-claudin18.2 Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187104</classIRI>
<classLabel>Anti-Claudin18.2 CAR-T Cells IM92</classLabel>
<newAxiom>'Anti-Claudin18.2 CAR-T Cells IM92' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Anti-Claudin18.2 CAR-T Cells IM92' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187109</classIRI>
<classLabel>Anti-GPC3/Anti-CD3 Bispecific Antibody CM350</classLabel>
<newAxiom>'Anti-GPC3/Anti-CD3 Bispecific Antibody CM350' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-GPC3/Anti-CD3 Bispecific Antibody CM350' SubClassOf 'Bispecific Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187107</classIRI>
<classLabel>RET Inhibitor SY-5007</classLabel>
<newAxiom>'RET Inhibitor SY-5007' SubClassOf 'RET Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187108</classIRI>
<classLabel>Adenosine A2B Receptor Antagonist TT-702</classLabel>
<newAxiom>'Adenosine A2B Receptor Antagonist TT-702' SubClassOf 'Immunostimulant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187198</classIRI>
<classLabel>ERBB2 Exon 19 Mutation</classLabel>
<newAxiom>'ERBB2 Exon 19 Mutation' SubClassOf 'ERBB2 Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187199</classIRI>
<classLabel>Nodule Internal Feature</classLabel>
<newAxiom>'Nodule Internal Feature' SubClassOf 'Morphologic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187192</classIRI>
<classLabel>Refractory Childhood Osteosarcoma</classLabel>
<newAxiom>'Refractory Childhood Osteosarcoma' EquivalentTo 'Refractory Osteosarcoma' and 'Refractory Childhood Malignant Neoplasm' and 'Childhood Osteosarcoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187193</classIRI>
<classLabel>Refractory Childhood Rhabdomyosarcoma</classLabel>
<newAxiom>'Refractory Childhood Rhabdomyosarcoma' EquivalentTo 'Refractory Rhabdomyosarcoma' and 'Refractory Childhood Soft Tissue Sarcoma' and 'Childhood Rhabdomyosarcoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187190</classIRI>
<classLabel>Lactate Dehydrogenase Ratio</classLabel>
<newAxiom>'Lactate Dehydrogenase Ratio' SubClassOf 'Lactate Dehydrogenase Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187191</classIRI>
<classLabel>LymphGen Algorithm</classLabel>
<newAxiom>'LymphGen Algorithm' SubClassOf 'Algorithm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187196</classIRI>
<classLabel>Recurrent Childhood Lymphoma</classLabel>
<newAxiom>'Recurrent Childhood Lymphoma' EquivalentTo 'Recurrent Lymphoma' and 'Recurrent Childhood Malignant Neoplasm' and 'Childhood Lymphoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187197</classIRI>
<classLabel>Refractory Childhood Lymphoma</classLabel>
<newAxiom>'Refractory Childhood Lymphoma' EquivalentTo 'Refractory Lymphoma' and 'Refractory Childhood Malignant Neoplasm' and 'Childhood Lymphoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187194</classIRI>
<classLabel>Refractory Childhood Soft Tissue Sarcoma</classLabel>
<newAxiom>'Refractory Childhood Soft Tissue Sarcoma' EquivalentTo 'Refractory Soft Tissue Sarcoma' and 'Refractory Childhood Malignant Neoplasm' and 'Childhood Soft Tissue Sarcoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187195</classIRI>
<classLabel>Oligometastatic Lung Carcinoma</classLabel>
<newAxiom>'Oligometastatic Lung Carcinoma' EquivalentTo 'Metastatic Lung Carcinoma' and ('Disease_Has_Finding' some 'Oligometastatic Disease')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187189</classIRI>
<classLabel>Recurrent Childhood Osteosarcoma</classLabel>
<newAxiom>'Recurrent Childhood Osteosarcoma' EquivalentTo 'Recurrent Childhood Malignant Neoplasm' and 'Childhood Osteosarcoma' and 'Recurrent Osteosarcoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187187</classIRI>
<classLabel>Recombinant Human Hyaluronidase PH20 Antibody</classLabel>
<newAxiom>'Recombinant Human Hyaluronidase PH20 Antibody' SubClassOf 'Anti-Drug Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187181</classIRI>
<classLabel>ERBB2 NP_004439.2:p.L841V</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.L841V' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2521CG'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.L841V' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187182</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2596CA</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2596CA' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.L866M'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2596CA' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187180</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2521CG</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2521CG' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2521CG' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.L841V'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187185</classIRI>
<classLabel>ERBB2 NP_004439.2:p.R896C</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.R896C' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2686CT'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.R896C' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187186</classIRI>
<classLabel>Carbon C11 Nicotine</classLabel>
<newAxiom>'Carbon C11 Nicotine' SubClassOf 'Radioconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187183</classIRI>
<classLabel>ERBB2 NP_004439.2:p.L866M</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.L866M' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.L866M' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2596CA'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187184</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2686CT</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2686CT' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.R896C'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2686CT' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187178</classIRI>
<classLabel>ERBB2 NP_004439.2:p.Q709L</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.Q709L' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.Q709L' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2126AT'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187179</classIRI>
<classLabel>Anti-TIGIT Monoclonal Antibody TAB006</classLabel>
<newAxiom>'Anti-TIGIT Monoclonal Antibody TAB006' SubClassOf 'Anti-TIGIT Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-TIGIT Monoclonal Antibody TAB006' SubClassOf 'Antineoplastic Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187176</classIRI>
<classLabel>ERBB2 NP_004439.2:p.E693K</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.E693K' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2077GA'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.E693K' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187177</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2126AT</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2126AT' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2126AT' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.Q709L'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187170</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2331_2339dup</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2331_2339dup' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.G778_P780dup'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2331_2339dup' SubClassOf 'Activating ERBB2 Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2331_2339dup' SubClassOf 'ERBB2 Exon 20 Insertion Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187171</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2332_2340dup</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2332_2340dup' SubClassOf 'ERBB2 Exon 20 Insertion Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2332_2340dup' SubClassOf 'Activating ERBB2 Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2332_2340dup' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.G778_P780dup'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187174</classIRI>
<classLabel>ERBB2 NP_004439.2:p.G660D</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.G660D' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.G660D' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.1979GA'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187175</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2077GA</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2077GA' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2077GA' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.E693K'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187172</classIRI>
<classLabel>ERBB2 NP_004439.2:p.G778_P780dup</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.G778_P780dup' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.G778_P780dup' SubClassOf ('Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2331_2339dup') and ('Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2332_2340dup')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187173</classIRI>
<classLabel>ERBB2 NM_004448.4:c.1979GA</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.1979GA' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.G660D'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.1979GA' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187167</classIRI>
<classLabel>ERBB2 NP_004439.2:p.G776V</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.G776V' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.G776V' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2327GT'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187168</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2326GT</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2326GT' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2326GT' SubClassOf 'ERBB2 Exon 20 Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2326GT' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.G776C'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187165</classIRI>
<classLabel>ERBB2 NP_004439.2:p.H878Y</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.H878Y' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.H878Y' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2632CT'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187166</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2327GT</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2327GT' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2327GT' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.G776V'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2327GT' SubClassOf 'ERBB2 Exon 20 Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187169</classIRI>
<classLabel>ERBB2 NP_004439.2:p.G776C</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.G776C' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2326GT'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.G776C' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187160</classIRI>
<classLabel>Unresectable Hormone Receptor-Positive Breast Carcinoma</classLabel>
<newAxiom>'Unresectable Hormone Receptor-Positive Breast Carcinoma' EquivalentTo 'Hormone Receptor-Positive Breast Carcinoma' and 'Unresectable Breast Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187163</classIRI>
<classLabel>Advanced Lung Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Advanced Lung Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Advanced Lung Non-Squamous Non-Small Cell Carcinoma' and 'Advanced Lung Neuroendocrine Neoplasm' and 'Metastatic Lung Large Cell Neuroendocrine Carcinoma' and 'Advanced Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187164</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2632CT</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2632CT' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2632CT' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.H878Y'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187161</classIRI>
<classLabel>Unresectable HER2-Negative Breast Carcinoma</classLabel>
<newAxiom>'Unresectable HER2-Negative Breast Carcinoma' EquivalentTo 'Unresectable Breast Carcinoma' and 'HER2-Negative Breast Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187162</classIRI>
<classLabel>Unresectable Lung Large Cell Neuroendocrine Carcinoma</classLabel>
<newAxiom>'Unresectable Lung Large Cell Neuroendocrine Carcinoma' EquivalentTo 'Unresectable Lung Non-Squamous Non-Small Cell Carcinoma' and 'Unresectable Lung Neuroendocrine Neoplasm' and 'Unresectable Large Cell Neuroendocrine Carcinoma' and 'Lung Large Cell Neuroendocrine Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187156</classIRI>
<classLabel>ERBB2 NP_004439.2:p.T862A</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.T862A' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2584AG'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.T862A' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187157</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2264_2278del</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2264_2278del' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.L755_T759del'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2264_2278del' SubClassOf 'Activating ERBB2 Mutation'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2264_2278del' SubClassOf 'ERBB2 Exon 19 Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187154</classIRI>
<classLabel>ERBB2 NP_004439.2:p.L755P</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.L755P' SubClassOf 'ERBB2 NP_004439.2:p.L755X'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.L755P' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2263_2264delinsCC'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187155</classIRI>
<classLabel>ERBB2 NM_004448.4:c.2584AG</classLabel>
<newAxiom>'ERBB2 NM_004448.4:c.2584AG' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'ERBB2 NP_004439.2:p.T862A'</newAxiom>
<newAxiom>'ERBB2 NM_004448.4:c.2584AG' SubClassOf 'Activating ERBB2 Point Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187158</classIRI>
<classLabel>ERBB2 NP_004439.2:p.L755_T759del</classLabel>
<newAxiom>'ERBB2 NP_004439.2:p.L755_T759del' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'ERBB2 NM_004448.4:c.2264_2278del'</newAxiom>
<newAxiom>'ERBB2 NP_004439.2:p.L755_T759del' SubClassOf 'ERBB2 Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C187159</classIRI>
<classLabel>PD-L1 Inhibitor AN4005</classLabel>
<newAxiom>'PD-L1 Inhibitor AN4005' SubClassOf 'PD-1 Ligand Inhibitor'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
</deletedClasses>
</diffReport>