<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
174
</numberChangedClasses>
<numberNewClasses>
370
</numberNewClasses>
<numberDeletedClasses>
0
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28235</classIRI>
<classLabel>Valacyclovir</classLabel>
<deletedAxiom>&apos;Valacyclovir&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C53311</classIRI>
<classLabel>Panel Study</classLabel>
<deletedAxiom>&apos;Panel Study&apos; SubClassOf &apos;Study&apos;</deletedAxiom>
<newAxiom>&apos;Panel Study&apos; SubClassOf &apos;Longitudinal Study&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C130011</classIRI>
<classLabel>Anti-HER2 Antibody-drug Conjugate RC48</classLabel>
<deletedAxiom>&apos;Anti-HER2 Antibody-drug Conjugate RC48&apos; SubClassOf &apos;Anti-HER2 Antibody-drug Conjugate&apos;</deletedAxiom>
<newAxiom>&apos;Anti-HER2 Antibody-drug Conjugate RC48&apos; SubClassOf &apos;Retired Concept Current Year&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14080</classIRI>
<classLabel>DAG/PE-Binding Domain</classLabel>
<deletedAxiom>&apos;DAG/PE-Binding Domain&apos; SubClassOf &apos;Ligand Binding Domain&apos;</deletedAxiom>
<newAxiom>&apos;DAG/PE-Binding Domain&apos; SubClassOf &apos;Metal Binding Site&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73197</classIRI>
<classLabel>Fialuridine</classLabel>
<deletedAxiom>&apos;Fialuridine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73198</classIRI>
<classLabel>Buciclovir</classLabel>
<deletedAxiom>&apos;Buciclovir&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73200</classIRI>
<classLabel>Torcitabine</classLabel>
<deletedAxiom>&apos;Torcitabine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73201</classIRI>
<classLabel>Elvucitabine</classLabel>
<deletedAxiom>&apos;Elvucitabine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73202</classIRI>
<classLabel>Fiacitabine</classLabel>
<deletedAxiom>&apos;Fiacitabine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73203</classIRI>
<classLabel>Desciclovir</classLabel>
<deletedAxiom>&apos;Desciclovir&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73204</classIRI>
<classLabel>Rociclovir</classLabel>
<deletedAxiom>&apos;Rociclovir&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150680</classIRI>
<classLabel>MEK Inhibitor SHR 7390</classLabel>
<newAxiom>&apos;MEK Inhibitor SHR 7390&apos; SubClassOf &apos;Mitogen-Activated Protein Kinase Kinase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48813</classIRI>
<classLabel>Ropidoxuridine</classLabel>
<deletedAxiom>&apos;Ropidoxuridine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34442</classIRI>
<classLabel>Chemical Burn</classLabel>
<newAxiom>&apos;Chemical Burn&apos; SubClassOf &apos;Chemical Injury&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34627</classIRI>
<classLabel>Frostbite</classLabel>
<newAxiom>&apos;Frostbite&apos; SubClassOf &apos;Integumentary System Signs and Symptoms&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C139552</classIRI>
<classLabel>Mevociclib</classLabel>
<newAxiom>&apos;Mevociclib&apos; SubClassOf &apos;Cyclin-Dependent Kinase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C139559</classIRI>
<classLabel>SHP2 Inhibitor TNO155</classLabel>
<deletedAxiom>&apos;SHP2 Inhibitor TNO155&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;SHP2 Inhibitor TNO155&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185612</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178973</classIRI>
<classLabel>Roswell Park Memorial Institute 1640 Medium</classLabel>
<deletedAxiom>&apos;Roswell Park Memorial Institute 1640 Medium&apos; SubClassOf &apos;Medium&apos;</deletedAxiom>
<newAxiom>&apos;Roswell Park Memorial Institute 1640 Medium&apos; SubClassOf &apos;Growth Medium&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178964</classIRI>
<classLabel>Penicillin/Streptomycin Cell Culture Solution</classLabel>
<deletedAxiom>&apos;Penicillin/Streptomycin Cell Culture Solution&apos; SubClassOf &apos;Medium&apos;</deletedAxiom>
<newAxiom>&apos;Penicillin/Streptomycin Cell Culture Solution&apos; SubClassOf &apos;Growth Medium&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178950</classIRI>
<classLabel>L-Glutamine Solution</classLabel>
<deletedAxiom>&apos;L-Glutamine Solution&apos; SubClassOf &apos;Medium&apos;</deletedAxiom>
<newAxiom>&apos;L-Glutamine Solution&apos; SubClassOf &apos;Growth Medium&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178933</classIRI>
<classLabel>HEPES Solution</classLabel>
<deletedAxiom>&apos;HEPES Solution&apos; SubClassOf &apos;Medium&apos;</deletedAxiom>
<newAxiom>&apos;HEPES Solution&apos; SubClassOf &apos;Buffer&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178908</classIRI>
<classLabel>Dulbecco&apos;s Phosphate-Buffered Saline</classLabel>
<deletedAxiom>&apos;Dulbecco&apos;s Phosphate-Buffered Saline&apos; SubClassOf &apos;Industrial Aid&apos;</deletedAxiom>
<newAxiom>&apos;Dulbecco&apos;s Phosphate-Buffered Saline&apos; SubClassOf &apos;Buffer&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C164146</classIRI>
<classLabel>Cedazuridine</classLabel>
<deletedAxiom>&apos;Cedazuridine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C178469</classIRI>
<classLabel>SHP2 Inhibitor PF-07284892</classLabel>
<deletedAxiom>&apos;SHP2 Inhibitor PF-07284892&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;SHP2 Inhibitor PF-07284892&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185612</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29490</classIRI>
<classLabel>Tenofovir</classLabel>
<deletedAxiom>&apos;Tenofovir&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54455</classIRI>
<classLabel>SPL Drug Route of Administration Terminology</classLabel>
<newAxiom>&apos;SPL Drug Route of Administration Terminology&apos; SubClassOf &apos;FDA Pharmaceutical Quality/CMC Terminology&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29535</classIRI>
<classLabel>Valacyclovir Hydrochloride</classLabel>
<deletedAxiom>&apos;Valacyclovir Hydrochloride&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118585</classIRI>
<classLabel>SMAD5 Gene</classLabel>
<deletedAxiom>&apos;SMAD5 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;SMAD5 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29763</classIRI>
<classLabel>RAS-Related Protein Rap-1A</classLabel>
<deletedAxiom>&apos;RAS-Related Protein Rap-1A&apos; EquivalentTo &apos;Signaling Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nectin Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAP1A Gene&apos;)</deletedAxiom>
<newAxiom>&apos;RAS-Related Protein Rap-1A&apos; EquivalentTo &apos;RAS Superfamily Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Focal Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Leukocyte Transendothelial Migration Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Neurotrophin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Tight Junction Assembly Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Long-Term Potentiation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Chemokine Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Renal Cell Carcinoma Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;AlphaM/Beta2 Integrin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Adherens Junction Formation Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin B Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Erythropoietin Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Interferon-Gamma Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Nectin Adhesion Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;PDGFR-beta Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Reelin Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Hepatocyte Growth Factor Receptor Signaling Pathway PID&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;NTRK1/MAPK Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Signaling Protein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Signal Transduction&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;RAP1A Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157619</classIRI>
<classLabel>Carboplatin/Nab-Paclitaxel/Pembrolizumab Regimen</classLabel>
<deletedAxiom>&apos;Carboplatin/Nab-Paclitaxel/Pembrolizumab Regimen&apos; SubClassOf &apos;Chemotherapy_Regimen_Has_Component&apos; some &apos;Pemetrexed Disodium&apos;</deletedAxiom>
<newAxiom>&apos;Carboplatin/Nab-Paclitaxel/Pembrolizumab Regimen&apos; SubClassOf &apos;Chemotherapy_Regimen_Has_Component&apos; some &apos;Nab-paclitaxel&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88333</classIRI>
<classLabel>Gamma-Secretase Inhibitor RO4929097</classLabel>
<deletedAxiom>&apos;Gamma-Secretase Inhibitor RO4929097&apos; SubClassOf &apos;Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;Gamma-Secretase Inhibitor RO4929097&apos; SubClassOf &apos;Protease Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74062</classIRI>
<classLabel>MET Tyrosine Kinase Inhibitor SGX523</classLabel>
<deletedAxiom>&apos;MET Tyrosine Kinase Inhibitor SGX523&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;MET Tyrosine Kinase Inhibitor SGX523&apos; SubClassOf &apos;c-Met Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2379</classIRI>
<classLabel>Uridine Triacetate</classLabel>
<deletedAxiom>&apos;Uridine Triacetate&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
<newAxiom>&apos;Uridine Triacetate&apos; SubClassOf &apos;Agent Affecting Blood or Body Fluid&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2682</classIRI>
<classLabel>Ziv-Aflibercept</classLabel>
<deletedAxiom>&apos;Ziv-Aflibercept&apos; SubClassOf &apos;Targeted Therapy Agent&apos;</deletedAxiom>
<newAxiom>&apos;Ziv-Aflibercept&apos; SubClassOf &apos;VEGFR-targeting Agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2629</classIRI>
<classLabel>Valganciclovir</classLabel>
<deletedAxiom>&apos;Valganciclovir&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2633</classIRI>
<classLabel>Pelitrexol</classLabel>
<deletedAxiom>&apos;Pelitrexol&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
<newAxiom>&apos;Pelitrexol&apos; SubClassOf &apos;Folate Antagonist&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C138996</classIRI>
<classLabel>Icotinib</classLabel>
<newAxiom>&apos;Icotinib&apos; SubClassOf &apos;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C35622</classIRI>
<classLabel>Caustic Injury</classLabel>
<deletedAxiom>&apos;Caustic Injury&apos; SubClassOf &apos;Injury&apos;</deletedAxiom>
<newAxiom>&apos;Caustic Injury&apos; SubClassOf &apos;Chemical Injury&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177417</classIRI>
<classLabel>SHP2 Inhibitor BBP-398</classLabel>
<deletedAxiom>&apos;SHP2 Inhibitor BBP-398&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;SHP2 Inhibitor BBP-398&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185612</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118709</classIRI>
<classLabel>Chemical Burn of Eye</classLabel>
<deletedAxiom>&apos;Chemical Burn of Eye&apos; SubClassOf &apos;Burn&apos;</deletedAxiom>
<newAxiom>&apos;Chemical Burn of Eye&apos; SubClassOf &apos;Chemical Burn&apos;</newAxiom>
<newAxiom>&apos;Chemical Burn of Eye&apos; SubClassOf &apos;Ocular Injury&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C171935</classIRI>
<classLabel>Betibeglogene Darolentivec</classLabel>
<deletedAxiom>&apos;Betibeglogene Darolentivec&apos; SubClassOf &apos;Viral Vector&apos;</deletedAxiom>
<newAxiom>&apos;Betibeglogene Darolentivec&apos; SubClassOf &apos;Gene Therapy Agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16676</classIRI>
<classLabel>Hemoglobin</classLabel>
<newAxiom>&apos;Hemoglobin&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;Globin Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C171649</classIRI>
<classLabel>Cedazuridine/Azacitidine Combination Agent ASTX030</classLabel>
<deletedAxiom>&apos;Cedazuridine/Azacitidine Combination Agent ASTX030&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;Cedazuridine/Azacitidine Combination Agent ASTX030&apos; SubClassOf &apos;Cytidine Deaminase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C171269</classIRI>
<classLabel>Spinocerebellar Ataxia Type 42</classLabel>
<newAxiom>&apos;Spinocerebellar Ataxia Type 42&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some &apos;CACNA1G Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C36646</classIRI>
<classLabel>Loss of Chromosome 11q ATM Gene Locus</classLabel>
<deletedAxiom>&apos;Loss of Chromosome 11q ATM Gene Locus&apos; SubClassOf &apos;Rearrangement of 11q&apos;</deletedAxiom>
<deletedAxiom>&apos;Loss of Chromosome 11q ATM Gene Locus&apos; SubClassOf &apos;Molecular_Abnormality_Involves_Gene&apos; some &apos;ATM Gene&apos;</deletedAxiom>
<newAxiom>&apos;Loss of Chromosome 11q ATM Gene Locus&apos; SubClassOf &apos;ATM Gene Deletion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95504</classIRI>
<classLabel>Hemoglobin H Disease</classLabel>
<newAxiom>&apos;Hemoglobin H Disease&apos; SubClassOf &apos;Disease_May_Have_Finding&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185517</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95535</classIRI>
<classLabel>Alpha Thalassemia Trait</classLabel>
<newAxiom>&apos;Alpha Thalassemia Trait&apos; SubClassOf &apos;Disease_May_Have_Finding&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185512</newAxiom>
<newAxiom>&apos;Alpha Thalassemia Trait&apos; SubClassOf &apos;Disease_May_Have_Finding&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185513</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95536</classIRI>
<classLabel>Alpha Thalassemia Silent Carrier</classLabel>
<newAxiom>&apos;Alpha Thalassemia Silent Carrier&apos; SubClassOf &apos;Disease_May_Have_Finding&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185502</newAxiom>
<newAxiom>&apos;Alpha Thalassemia Silent Carrier&apos; SubClassOf &apos;Disease_May_Have_Molecular_Abnormality&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185461</newAxiom>
<newAxiom>&apos;Alpha Thalassemia Silent Carrier&apos; SubClassOf &apos;Disease_May_Have_Molecular_Abnormality&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185460</newAxiom>
<newAxiom>&apos;Alpha Thalassemia Silent Carrier&apos; SubClassOf &apos;Disease_May_Have_Finding&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185504</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C152817</classIRI>
<classLabel>Valnivudine</classLabel>
<deletedAxiom>&apos;Valnivudine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113294</classIRI>
<classLabel>Metatinib Tromethamine</classLabel>
<deletedAxiom>&apos;Metatinib Tromethamine&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<deletedAxiom>&apos;Metatinib Tromethamine&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;Metatinib Tromethamine&apos; SubClassOf &apos;BCR-ABL Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95738</classIRI>
<classLabel>MEK Inhibitor GDC-0623</classLabel>
<deletedAxiom>&apos;MEK Inhibitor GDC-0623&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;MEK Inhibitor GDC-0623&apos; SubClassOf &apos;Mitogen-Activated Protein Kinase Kinase Inhibitor&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95729</classIRI>
<classLabel>Merestinib</classLabel>
<deletedAxiom>&apos;Merestinib&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;Merestinib&apos; SubClassOf &apos;c-Met Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C166932</classIRI>
<classLabel>Cobimetinib Fumarate</classLabel>
<newAxiom>&apos;Cobimetinib Fumarate&apos; SubClassOf &apos;Mitogen-Activated Protein Kinase Kinase Inhibitor&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C152150</classIRI>
<classLabel>Raluridine</classLabel>
<deletedAxiom>&apos;Raluridine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
<newAxiom>&apos;Raluridine&apos; SubClassOf &apos;Nucleoside Reverse Transcriptase Inhibitor&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C152135</classIRI>
<classLabel>Rabacfosadine Succinate</classLabel>
<deletedAxiom>&apos;Rabacfosadine Succinate&apos; SubClassOf &apos;Antimetabolite&apos;</deletedAxiom>
<newAxiom>&apos;Rabacfosadine Succinate&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</newAxiom>
<newAxiom>&apos;Rabacfosadine Succinate&apos; SubClassOf &apos;DNA Polymerase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C152134</classIRI>
<classLabel>Rabacfosadine</classLabel>
<deletedAxiom>&apos;Rabacfosadine&apos; SubClassOf &apos;Antimetabolite&apos;</deletedAxiom>
<newAxiom>&apos;Rabacfosadine&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</newAxiom>
<newAxiom>&apos;Rabacfosadine&apos; SubClassOf &apos;DNA Polymerase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C166775</classIRI>
<classLabel>Besifovir</classLabel>
<deletedAxiom>&apos;Besifovir&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
<newAxiom>&apos;Besifovir&apos; SubClassOf &apos;Antiviral Agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17332</classIRI>
<classLabel>Insulin-Like Growth Factor-Binding Protein</classLabel>
<deletedAxiom>&apos;Insulin-Like Growth Factor-Binding Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Subcellular Protein Targeting&apos;</deletedAxiom>
<newAxiom>&apos;Insulin-Like Growth Factor-Binding Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Intracellular Signaling Process&apos;</newAxiom>
<newAxiom>&apos;Insulin-Like Growth Factor-Binding Protein&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transport Process&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C166474</classIRI>
<classLabel>Pemafibrate</classLabel>
<deletedAxiom>&apos;Pemafibrate&apos; SubClassOf &apos;Neonatal Coagulation Disorder, AE&apos;</deletedAxiom>
<newAxiom>&apos;Pemafibrate&apos; SubClassOf &apos;Peroxisome Proliferator-Activated Receptor Agonist&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C4072</classIRI>
<classLabel>Mesonephric Adenocarcinoma</classLabel>
<deletedAxiom>&apos;Mesonephric Adenocarcinoma&apos; EquivalentTo &apos;Adenocarcinoma&apos; and &apos;Malignant Female Reproductive System Neoplasm&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Female Reproductive System&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Mesonephric Remnants&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Mesonephric Differentiation&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Tissue of Mullerian Origin Present&apos;)</deletedAxiom>
<newAxiom>&apos;Mesonephric Adenocarcinoma&apos; EquivalentTo &apos;Female Reproductive System Carcinoma&apos; and &apos;Adenocarcinoma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Female Reproductive System&apos;) and (&apos;Disease_Has_Normal_Tissue_Origin&apos; some &apos;Mesonephric Remnants&apos;) and (&apos;Disease_Has_Finding&apos; some &apos;Mesonephric Differentiation&apos;) and (&apos;Disease_Excludes_Finding&apos; some &apos;Tissue of Mullerian Origin Present&apos;)</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179222</classIRI>
<classLabel>Recurrent Diffuse Midline Glioma, H3 K27M-Mutant</classLabel>
<deletedAxiom>&apos;Recurrent Diffuse Midline Glioma, H3 K27M-Mutant&apos; EquivalentTo &apos;Diffuse Midline Glioma, H3 K27M-Mutant&apos; and &apos;Recurrent Malignant Glioma&apos; and &apos;Recurrent Malignant Brain Neoplasm&apos;</deletedAxiom>
<newAxiom>&apos;Recurrent Diffuse Midline Glioma, H3 K27M-Mutant&apos; EquivalentTo &apos;Diffuse Midline Glioma, H3 K27M-Mutant&apos; and &apos;Recurrent Malignant Glioma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179267</classIRI>
<classLabel>Extended-Release MetAP2 Inhibitor APL-1501</classLabel>
<deletedAxiom>&apos;Extended-Release MetAP2 Inhibitor APL-1501&apos; SubClassOf &apos;Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;Extended-Release MetAP2 Inhibitor APL-1501&apos; SubClassOf &apos;Protease Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131187</classIRI>
<classLabel>Pycnodysostosis</classLabel>
<newAxiom>&apos;Pycnodysostosis&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some &apos;CTSK Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131179</classIRI>
<classLabel>MET Exon 14 Skipping Mutation</classLabel>
<newAxiom>&apos;MET Exon 14 Skipping Mutation&apos; SubClassOf &apos;Splice-Site Mutation&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C170540</classIRI>
<classLabel>Tenofovir Anhydrous</classLabel>
<deletedAxiom>&apos;Tenofovir Anhydrous&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C184374</classIRI>
<classLabel>CDC7 Inhibitor TQB3824</classLabel>
<newAxiom>&apos;CDC7 Inhibitor TQB3824&apos; SubClassOf &apos;Serine/Threonine Kinase Inhibitor&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96071</classIRI>
<classLabel>Stability Study Data File Reason Terminology</classLabel>
<deletedAxiom>&apos;Stability Study Data File Reason Terminology&apos; SubClassOf &apos;Reason&apos;</deletedAxiom>
<deletedAxiom>&apos;Stability Study Data File Reason Terminology&apos; SubClassOf &apos;FDA Stability Data Standards Terminology&apos;</deletedAxiom>
<newAxiom>&apos;Stability Study Data File Reason Terminology&apos; SubClassOf &apos;FDA Pharmaceutical Quality/CMC Terminology&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159198</classIRI>
<classLabel>c-KIT Inhibitor</classLabel>
<newAxiom>&apos;c-KIT Inhibitor&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185222</classIRI>
<classLabel>MAPK Pathway Alteration Positive</classLabel>
<newAxiom>&apos;MAPK Pathway Alteration Positive&apos; SubClassOf &apos;Positive Laboratory Test Result&apos;</newAxiom>
<newAxiom>&apos;MAPK Pathway Alteration Positive&apos; SubClassOf &apos;Signaling Pathway Status&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185214</classIRI>
<classLabel>MAPK Pathway Activating Gene Alteration Positive</classLabel>
<deletedAxiom>&apos;MAPK Pathway Activating Gene Alteration Positive&apos; SubClassOf &apos;Genetic Finding&apos;</deletedAxiom>
<deletedAxiom>&apos;MAPK Pathway Activating Gene Alteration Positive&apos; SubClassOf &apos;Signaling Pathway Status&apos;</deletedAxiom>
<newAxiom>&apos;MAPK Pathway Activating Gene Alteration Positive&apos; SubClassOf &apos;MAPK Pathway Alteration Positive&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C151941</classIRI>
<classLabel>Acyclic Nucleoside Phosphonate Prodrug ABI-1968</classLabel>
<deletedAxiom>&apos;Acyclic Nucleoside Phosphonate Prodrug ABI-1968&apos; SubClassOf &apos;Antimetabolite&apos;</deletedAxiom>
<newAxiom>&apos;Acyclic Nucleoside Phosphonate Prodrug ABI-1968&apos; SubClassOf &apos;Antiviral Agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96764</classIRI>
<classLabel>Valomaciclovir</classLabel>
<deletedAxiom>&apos;Valomaciclovir&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82254</classIRI>
<classLabel>Maribavir</classLabel>
<deletedAxiom>&apos;Maribavir&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82253</classIRI>
<classLabel>Lobucavir</classLabel>
<deletedAxiom>&apos;Lobucavir&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82696</classIRI>
<classLabel>MEK Inhibitor RO4987655</classLabel>
<deletedAxiom>&apos;MEK Inhibitor RO4987655&apos; SubClassOf &apos;Serine/Threonine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;MEK Inhibitor RO4987655&apos; SubClassOf &apos;Mitogen-Activated Protein Kinase Kinase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18258</classIRI>
<classLabel>SMAD4 Gene</classLabel>
<deletedAxiom>&apos;SMAD4 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;SMAD4 Gene&apos; SubClassOf &apos;Transcription Factor Gene&apos;</newAxiom>
<newAxiom>&apos;SMAD4 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165500</classIRI>
<classLabel>Spinocerebellar Ataxia, Autosomal Recessive, with Axonal Neuropathy 2</classLabel>
<newAxiom>&apos;Spinocerebellar Ataxia, Autosomal Recessive, with Axonal Neuropathy 2&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some &apos;SETX Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C5123</classIRI>
<classLabel>Hemispheric Anaplastic Astrocytoma</classLabel>
<deletedAxiom>&apos;Hemispheric Anaplastic Astrocytoma&apos; EquivalentTo &apos;Malignant Brain Glioma&apos; and &apos;Malignant Cerebral Neoplasm&apos; and &apos;Cerebral Astrocytoma&apos; and &apos;Anaplastic Astrocytoma&apos; and (&apos;Disease_Has_Primary_Anatomic_Site&apos; some &apos;Cerebral Hemisphere&apos;)</deletedAxiom>
<newAxiom>&apos;Hemispheric Anaplastic Astrocytoma&apos; EquivalentTo &apos;Malignant Brain Glioma&apos; and &apos;Malignant Cerebral Neoplasm&apos; and &apos;Cerebral Astrocytoma&apos; and &apos;Anaplastic Astrocytoma&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131921</classIRI>
<classLabel>Transfer Ability</classLabel>
<deletedAxiom>&apos;Transfer Ability&apos; SubClassOf &apos;Clinical or Research Assessment Question&apos;</deletedAxiom>
<newAxiom>&apos;Transfer Ability&apos; SubClassOf &apos;Ability Question&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18504</classIRI>
<classLabel>SMAD3 Gene</classLabel>
<deletedAxiom>&apos;SMAD3 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;SMAD3 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
<newAxiom>&apos;SMAD3 Gene&apos; SubClassOf &apos;Transcription Factor Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179649</classIRI>
<classLabel>MEK inhibitor BI 3011441</classLabel>
<newAxiom>&apos;MEK inhibitor BI 3011441&apos; SubClassOf &apos;Mitogen-Activated Protein Kinase Kinase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106611</classIRI>
<classLabel>SMAD1 Gene</classLabel>
<deletedAxiom>&apos;SMAD1 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;SMAD1 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
<newAxiom>&apos;SMAD1 Gene&apos; SubClassOf &apos;Transcription Factor Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77393</classIRI>
<classLabel>Vidarabine Anhydrous</classLabel>
<deletedAxiom>&apos;Vidarabine Anhydrous&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168639</classIRI>
<classLabel>PQ/CMC Application Type Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Application Type Terminology&apos; SubClassOf &apos;FDA Pharmaceutical Quality/CMC Terminology&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Application Type Terminology&apos; SubClassOf &apos;Unused Subset Concept&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38047</classIRI>
<classLabel>Curative Surgery</classLabel>
<newAxiom>&apos;Curative Surgery&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185614</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77612</classIRI>
<classLabel>Peritoneal Fluid</classLabel>
<deletedAxiom>&apos;Peritoneal Fluid&apos; SubClassOf &apos;Biospecimen&apos;</deletedAxiom>
<newAxiom>&apos;Peritoneal Fluid&apos; SubClassOf &apos;Body Fluid or Substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38468</classIRI>
<classLabel>5-Hydroxypicolinaldehyde Thiosemicarbazone</classLabel>
<deletedAxiom>&apos;5-Hydroxypicolinaldehyde Thiosemicarbazone&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
<deletedAxiom>&apos;5-Hydroxypicolinaldehyde Thiosemicarbazone&apos; SubClassOf &apos;Ribonucleotide Reductase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;5-Hydroxypicolinaldehyde Thiosemicarbazone&apos; SubClassOf &apos;Antimetabolite&apos;</newAxiom>
<newAxiom>&apos;5-Hydroxypicolinaldehyde Thiosemicarbazone&apos; SubClassOf &apos;DNA Polymerase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C148509</classIRI>
<classLabel>CDC7 Kinase Inhibitor LY3143921 Hydrate</classLabel>
<newAxiom>&apos;CDC7 Kinase Inhibitor LY3143921 Hydrate&apos; SubClassOf &apos;Serine/Threonine Kinase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24567</classIRI>
<classLabel>SMAD6 Gene</classLabel>
<deletedAxiom>&apos;SMAD6 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;SMAD6 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24566</classIRI>
<classLabel>SMAD2 Gene</classLabel>
<deletedAxiom>&apos;SMAD2 Gene&apos; SubClassOf &apos;Signaling Pathway Gene&apos;</deletedAxiom>
<newAxiom>&apos;SMAD2 Gene&apos; SubClassOf &apos;Adaptor Signaling Protein Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97511</classIRI>
<classLabel>MET Tyrosine Kinase Inhibitor SAR125844</classLabel>
<deletedAxiom>&apos;MET Tyrosine Kinase Inhibitor SAR125844&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;MET Tyrosine Kinase Inhibitor SAR125844&apos; SubClassOf &apos;c-Met Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C83771</classIRI>
<classLabel>Ibacitabine</classLabel>
<deletedAxiom>&apos;Ibacitabine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129982</classIRI>
<classLabel>Spinocerebellar Ataxia Type 1</classLabel>
<newAxiom>&apos;Spinocerebellar Ataxia Type 1&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some &apos;ATXN1 Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C83920</classIRI>
<classLabel>Navuridine</classLabel>
<deletedAxiom>&apos;Navuridine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78156</classIRI>
<classLabel>Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2</classLabel>
<deletedAxiom>&apos;Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Parkinson&apos;s Disease&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LRRK2 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2&apos; EquivalentTo &apos;Serine/Threonine Protein Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Parkinson&apos;s Disease Pathway BioCarta&apos;) and (&apos;Gene_Product_Malfunction_Associated_With_Disease&apos; some &apos;Parkinson&apos;s Disease&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;WD Repeat&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;Leucine-Rich Repeat&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Serine/Threonine Phosphorylation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;LRRK2 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129699</classIRI>
<classLabel>Beta Thalassemia Major</classLabel>
<newAxiom>&apos;Beta Thalassemia Major&apos; SubClassOf &apos;Disease_Has_Finding&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185533</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78298</classIRI>
<classLabel>Female Genital Tract Fistula</classLabel>
<deletedAxiom>&apos;Female Genital Tract Fistula&apos; SubClassOf &apos;Fistula&apos;</deletedAxiom>
<newAxiom>&apos;Female Genital Tract Fistula&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185462</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129310</classIRI>
<classLabel>H3 K27M Variant</classLabel>
<deletedAxiom>&apos;H3 K27M Variant&apos; SubClassOf &apos;H3 Protein Variant&apos;</deletedAxiom>
<newAxiom>&apos;H3 K27M Variant&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185375</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129309</classIRI>
<classLabel>Diffuse Midline Glioma, H3 K27M-Mutant</classLabel>
<deletedAxiom>&apos;Diffuse Midline Glioma, H3 K27M-Mutant&apos; EquivalentTo &apos;Malignant Brain Glioma&apos; and &apos;Diffuse Midline Glioma&apos; and (&apos;Disease_Has_Molecular_Abnormality&apos; some &apos;H3 K27M Variant&apos;)</deletedAxiom>
<newAxiom>&apos;Diffuse Midline Glioma, H3 K27M-Mutant&apos; EquivalentTo http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185368 and (&apos;Disease_Has_Molecular_Abnormality&apos; some &apos;H3 K27M Variant&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133870</classIRI>
<classLabel>PQ/CMC Validation Parameter Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Validation Parameter Terminology&apos; SubClassOf &apos;FDA Pharmaceutical Quality/CMC Terminology&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Validation Parameter Terminology&apos; SubClassOf &apos;Unused Subset Concept&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133848</classIRI>
<classLabel>PQ/CMC Chemical Structure Data File Type Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Chemical Structure Data File Type Terminology&apos; SubClassOf &apos;FDA Pharmaceutical Quality/CMC Terminology&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Chemical Structure Data File Type Terminology&apos; SubClassOf &apos;Unused Subset Concept&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133857</classIRI>
<classLabel>PQ/CMC Interpretation Code (text) Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Interpretation Code (text) Terminology&apos; SubClassOf &apos;FDA Pharmaceutical Quality/CMC Terminology&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Interpretation Code (text) Terminology&apos; SubClassOf &apos;Unused Subset Concept&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133850</classIRI>
<classLabel>PQ/CMC Compendial Method Verification Indicator Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Compendial Method Verification Indicator Terminology&apos; SubClassOf &apos;FDA Pharmaceutical Quality/CMC Terminology&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Compendial Method Verification Indicator Terminology&apos; SubClassOf &apos;Unused Subset Concept&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133855</classIRI>
<classLabel>PQ/CMC Drug Substance Product Indicator Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Drug Substance Product Indicator Terminology&apos; SubClassOf &apos;FDA Pharmaceutical Quality/CMC Terminology&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Drug Substance Product Indicator Terminology&apos; SubClassOf &apos;Unused Subset Concept&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C167205</classIRI>
<classLabel>EGFR/HER2 Inhibitor DZD9008</classLabel>
<deletedAxiom>&apos;EGFR/HER2 Inhibitor DZD9008&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;EGFR/HER2 Inhibitor DZD9008&apos; SubClassOf &apos;HER2 Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78850</classIRI>
<classLabel>HDAC/EGFR/HER2 Inhibitor CUDC-101</classLabel>
<deletedAxiom>&apos;HDAC/EGFR/HER2 Inhibitor CUDC-101&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;HDAC/EGFR/HER2 Inhibitor CUDC-101&apos; SubClassOf &apos;HER2 Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133680</classIRI>
<classLabel>ATM Gene Deletion</classLabel>
<deletedAxiom>&apos;ATM Gene Deletion&apos; SubClassOf &apos;Cytogenetic_Abnormality_Involves_Chromosome&apos; some &apos;Chromosome 14&apos;</deletedAxiom>
<newAxiom>&apos;ATM Gene Deletion&apos; SubClassOf &apos;Rearrangement of 11q&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172988</classIRI>
<classLabel>SHP2 Inhibitor RLY-1971</classLabel>
<deletedAxiom>&apos;SHP2 Inhibitor RLY-1971&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;SHP2 Inhibitor RLY-1971&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185612</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64627</classIRI>
<classLabel>EGFR/HER2 Inhibitor AV-412</classLabel>
<deletedAxiom>&apos;EGFR/HER2 Inhibitor AV-412&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;EGFR/HER2 Inhibitor AV-412&apos; SubClassOf &apos;HER2 Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C50473</classIRI>
<classLabel>Bowel Burn</classLabel>
<newAxiom>&apos;Bowel Burn&apos; SubClassOf &apos;Digestive System Injury&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C50538</classIRI>
<classLabel>Dura Mater Nick Cut Or Tear</classLabel>
<deletedAxiom>&apos;Dura Mater Nick Cut Or Tear&apos; SubClassOf &apos;Injury&apos;</deletedAxiom>
<newAxiom>&apos;Dura Mater Nick Cut Or Tear&apos; SubClassOf &apos;Nervous System Injury&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C50722</classIRI>
<classLabel>Radiation Burn</classLabel>
<newAxiom>&apos;Radiation Burn&apos; SubClassOf &apos;Radiation Damage&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C172193</classIRI>
<classLabel>FAK/ALK/ROS1 Inhibitor APG-2449</classLabel>
<newAxiom>&apos;FAK/ALK/ROS1 Inhibitor APG-2449&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C147120</classIRI>
<classLabel>MET Intron 13 Mutation</classLabel>
<newAxiom>&apos;MET Intron 13 Mutation&apos; SubClassOf &apos;Intronic Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C147122</classIRI>
<classLabel>MET Intron 14 Mutation</classLabel>
<newAxiom>&apos;MET Intron 14 Mutation&apos; SubClassOf &apos;Intronic Mutation&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84291</classIRI>
<classLabel>Krueppel-Like Factor 1</classLabel>
<deletedAxiom>&apos;Krueppel-Like Factor 1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;</deletedAxiom>
<deletedAxiom>&apos;Krueppel-Like Factor 1&apos; SubClassOf &apos;Transcription Factor&apos;</deletedAxiom>
<deletedAxiom>&apos;Krueppel-Like Factor 1&apos; SubClassOf &apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;</deletedAxiom>
<deletedAxiom>&apos;Krueppel-Like Factor 1&apos; SubClassOf &apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2H2 Zinc Finger&apos;</deletedAxiom>
<deletedAxiom>&apos;Krueppel-Like Factor 1&apos; SubClassOf &apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KLF1 Gene&apos;</deletedAxiom>
<newAxiom>&apos;Krueppel-Like Factor 1&apos; EquivalentTo &apos;Transcription Factor&apos; and (&apos;Gene_Product_Expressed_In_Tissue&apos; some &apos;Bone Marrow&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;C2H2 Zinc Finger&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Cell Differentiation Process&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Erythropoiesis&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Transcriptional Regulation&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;KLF1 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84289</classIRI>
<classLabel>KLF1 Gene</classLabel>
<newAxiom>&apos;KLF1 Gene&apos; SubClassOf &apos;Gene_Plays_Role_In_Process&apos; some &apos;Erythropoiesis&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98959</classIRI>
<classLabel>Mericitabine</classLabel>
<deletedAxiom>&apos;Mericitabine&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C148315</classIRI>
<classLabel>Spinocerebellar Ataxia Type 2</classLabel>
<newAxiom>&apos;Spinocerebellar Ataxia Type 2&apos; SubClassOf &apos;Disease_Mapped_To_Gene&apos; some &apos;ATXN2 Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114817</classIRI>
<classLabel>IMP3 Gene</classLabel>
<newAxiom>&apos;IMP3 Gene&apos; SubClassOf &apos;Translation Process Gene&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114820</classIRI>
<classLabel>U3 Small Nucleolar Ribonucleoprotein Protein IMP3</classLabel>
<deletedAxiom>&apos;U3 Small Nucleolar Ribonucleoprotein Protein IMP3&apos; EquivalentTo &apos;RNA Binding Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ribosomal Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RNA Recognition Motif&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ribonucleoprotein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IMP3 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;U3 Small Nucleolar Ribonucleoprotein Protein IMP3&apos; EquivalentTo &apos;RNA Binding Protein&apos; and &apos;Translation Process Protein&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ribosomal Biogenesis Pathway&apos;) and (&apos;Gene_Product_Has_Associated_Anatomy&apos; some &apos;Nucleolus&apos;) and (&apos;Gene_Product_Has_Structural_Domain_Or_Motif&apos; some &apos;RNA Recognition Motif&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;Ribonucleoprotein&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Processing&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;RNA Binding&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;IMP3 Gene&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128030</classIRI>
<classLabel>Evexomostat</classLabel>
<deletedAxiom>&apos;Evexomostat&apos; SubClassOf &apos;Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;Evexomostat&apos; SubClassOf &apos;Protease Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C181795</classIRI>
<classLabel>EGFR/HER2 Inhibitor TAS2940</classLabel>
<deletedAxiom>&apos;EGFR/HER2 Inhibitor TAS2940&apos; SubClassOf &apos;Antineoplastic Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;EGFR/HER2 Inhibitor TAS2940&apos; SubClassOf &apos;HER2 Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79848</classIRI>
<classLabel>MEK-1/MEKK-1 Inhibitor E6201</classLabel>
<deletedAxiom>&apos;MEK-1/MEKK-1 Inhibitor E6201&apos; SubClassOf &apos;Protein Kinase Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;MEK-1/MEKK-1 Inhibitor E6201&apos; SubClassOf &apos;Mitogen-Activated Protein Kinase Kinase Inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156383</classIRI>
<classLabel>del11q22.3/ATM Locus</classLabel>
<deletedAxiom>&apos;del11q22.3/ATM Locus&apos; SubClassOf &apos;ATM Gene Deletion&apos;</deletedAxiom>
<newAxiom>&apos;del11q22.3/ATM Locus&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185349</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156416</classIRI>
<classLabel>Anti-CD46 Antibody-drug Conjugate FOR46</classLabel>
<deletedAxiom>&apos;Anti-CD46 Antibody-drug Conjugate FOR46&apos; SubClassOf &apos;Monoclonal Antibody&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99040</classIRI>
<classLabel>Recto-Vesico-Vaginal Fistula</classLabel>
<deletedAxiom>&apos;Recto-Vesico-Vaginal Fistula&apos; SubClassOf &apos;Fistula&apos;</deletedAxiom>
<newAxiom>&apos;Recto-Vesico-Vaginal Fistula&apos; SubClassOf &apos;Female Genital Tract Fistula&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26160</classIRI>
<classLabel>Ephrin Type-A Receptor 8</classLabel>
<deletedAxiom>&apos;Ephrin Type-A Receptor 8&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;EphA Receptor Family&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nervous System Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EPHA8 Gene&apos;)</deletedAxiom>
<newAxiom>&apos;Ephrin Type-A Receptor 8&apos; EquivalentTo &apos;Receptor Tyrosine Kinase&apos; and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Axon Guidance Pathway&apos;) and (&apos;Gene_Product_Is_Element_In_Pathway&apos; some &apos;Ephrin A Forward Signaling Pathway&apos;) and (&apos;Gene_Product_Has_Organism_Source&apos; some &apos;Human&apos;) and (&apos;Gene_Product_Has_Biochemical_Function&apos; some &apos;EphA Receptor Family&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Tyrosine Phosphorylation&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Receptor Signaling&apos;) and (&apos;Gene_Product_Plays_Role_In_Biological_Process&apos; some &apos;Nervous System Development&apos;) and (&apos;Gene_Product_Encoded_By_Gene&apos; some &apos;EPHA8 Gene&apos;)</newAxiom>
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<classLabel>Penberol</classLabel>
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<newAxiom>&apos;Penberol&apos; SubClassOf &apos;Agent Targeting Cancer Metabolism&apos;</newAxiom>
</changedClass>
<changedClass>
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<classLabel>Ganciclovir Sodium</classLabel>
<deletedAxiom>&apos;Ganciclovir Sodium&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
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<changedClass>
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<classLabel>Burn of Esophagus</classLabel>
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<classLabel>Acyclovir</classLabel>
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</changedClass>
<changedClass>
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<classLabel>Liver Radiation Injury</classLabel>
<newAxiom>&apos;Liver Radiation Injury&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185645</newAxiom>
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<classLabel>Central Nervous System Radiation Injury</classLabel>
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<changedClass>
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<classLabel>Gastrointestinal Radiation Injury</classLabel>
<newAxiom>&apos;Gastrointestinal Radiation Injury&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185646</newAxiom>
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<classLabel>Renal Radiation Injury</classLabel>
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<changedClass>
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<classLabel>Flucytosine</classLabel>
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<newAxiom>&apos;Flucytosine&apos; SubClassOf &apos;Antifungal Agent&apos;</newAxiom>
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<changedClass>
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<classLabel>Fluorouracil</classLabel>
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<newAxiom>&apos;Fluorouracil&apos; SubClassOf &apos;Fluoropyrimidine&apos;</newAxiom>
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<changedClass>
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<classLabel>Ganciclovir</classLabel>
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<changedClass>
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<classLabel>Idoxuridine</classLabel>
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<newAxiom>&apos;Idoxuridine&apos; SubClassOf &apos;Radiosensitizing Agent&apos;</newAxiom>
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<changedClass>
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<classLabel>Eniluracil</classLabel>
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<newAxiom>&apos;Eniluracil&apos; SubClassOf &apos;Fluoropyrimidine&apos;</newAxiom>
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<changedClass>
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<classLabel>Zalcitabine</classLabel>
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<newAxiom>&apos;Zalcitabine&apos; SubClassOf &apos;Anti-HIV Agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C162480</classIRI>
<classLabel>MetAP2 Inhibitor APL-1202</classLabel>
<deletedAxiom>&apos;MetAP2 Inhibitor APL-1202&apos; SubClassOf &apos;Enzyme Inhibitor&apos;</deletedAxiom>
<newAxiom>&apos;MetAP2 Inhibitor APL-1202&apos; SubClassOf &apos;Protease Inhibitor&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176788</classIRI>
<classLabel>PQ/CMC Application Submission Type Terminology</classLabel>
<deletedAxiom>&apos;PQ/CMC Application Submission Type Terminology&apos; SubClassOf &apos;FDA Pharmaceutical Quality/CMC Terminology&apos;</deletedAxiom>
<newAxiom>&apos;PQ/CMC Application Submission Type Terminology&apos; SubClassOf &apos;Unused Subset Concept&apos;</newAxiom>
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<changedClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103920</classIRI>
<classLabel>Hemoglobin Barts</classLabel>
<newAxiom>&apos;Hemoglobin Barts&apos; SubClassOf &apos;Disease_Has_Finding&apos; some http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185522</newAxiom>
<newAxiom>&apos;Hemoglobin Barts&apos; SubClassOf &apos;Alpha Thalassemia&apos;</newAxiom>
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<changedClass>
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<newAxiom>&apos;SHP2 Inhibitor ERAS-601&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185612</newAxiom>
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<classLabel>Vidarabine</classLabel>
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<changedClass>
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<changedClass>
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<newAxiom>&apos;Combined Positive Score&apos; SubClassOf &apos;Immunohistochemical Status of PD-L1&apos;</newAxiom>
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<classLabel>Zidovudine</classLabel>
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<changedClass>
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<classLabel>Penciclovir</classLabel>
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<changedClass>
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<classLabel>Pradefovir Mesylate</classLabel>
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<changedClass>
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<classLabel>Pradefovir</classLabel>
<deletedAxiom>&apos;Pradefovir&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
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<changedClass>
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<classLabel>MAT2A Inhibitor IDE397</classLabel>
<deletedAxiom>&apos;MAT2A Inhibitor IDE397&apos; SubClassOf &apos;Tyrosine Kinase Inhibitor&apos;</deletedAxiom>
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<changedClass>
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<newAxiom>&apos;SHP2 Inhibitor SH3809&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185612</newAxiom>
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<newAxiom>&apos;Valopicitabine&apos; SubClassOf &apos;Antiviral Agent&apos;</newAxiom>
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<deletedAxiom>&apos;Valganciclovir Hydrochloride&apos; SubClassOf &apos;Purine Antagonist&apos;</deletedAxiom>
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<changedClass>
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<newAxiom>&apos;Disitamab Vedotin&apos; SubClassOf &apos;Anti-HER2 Antibody-drug Conjugate&apos;</newAxiom>
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<newAxiom>&apos;Fosdenopterin Hydrobromide&apos; SubClassOf &apos;Agent Affecting Nervous System&apos;</newAxiom>
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<changedClass>
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<classLabel>SHP2 Inhibitor JAB-3068</classLabel>
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<newAxiom>&apos;SHP2 Inhibitor JAB-3068&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185612</newAxiom>
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<newAxiom>&apos;Genitourinary Fistula&apos; SubClassOf http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185462</newAxiom>
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<deletedAxiom>&apos;Valopicitabine Dihydrochloride&apos; SubClassOf &apos;Pyrimidine Antagonist&apos;</deletedAxiom>
<newAxiom>&apos;Valopicitabine Dihydrochloride&apos; SubClassOf &apos;Antiviral Agent&apos;</newAxiom>
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<newAxiom>&apos;Fosdenopterin&apos; SubClassOf &apos;Agent Affecting Nervous System&apos;</newAxiom>
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<newAxiom>&apos;Levdobutamine Lactobionate&apos; SubClassOf &apos;Beta-Adrenergic Agonist&apos;</newAxiom>
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</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185648</classIRI>
<classLabel>Toxicity due to Psychiatric Drugs</classLabel>
<newAxiom>'Toxicity due to Psychiatric Drugs' SubClassOf 'Drug Toxicity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185630</classIRI>
<classLabel>Age in Days of Protocol Treatment Modification</classLabel>
<newAxiom>'Age in Days of Protocol Treatment Modification' SubClassOf 'Age-Days'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185632</classIRI>
<classLabel>Modification Type</classLabel>
<newAxiom>'Modification Type' SubClassOf 'Type'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185631</classIRI>
<classLabel>Function Test</classLabel>
<newAxiom>'Function Test' SubClassOf 'Test'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185634</classIRI>
<classLabel>Agent Substitution</classLabel>
<newAxiom>'Agent Substitution' SubClassOf 'Action Taken with Study Treatment'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185633</classIRI>
<classLabel>New Agent Addition</classLabel>
<newAxiom>'New Agent Addition' SubClassOf 'Action Taken with Study Treatment'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185636</classIRI>
<classLabel>Treatment Modification Rationale</classLabel>
<newAxiom>'Treatment Modification Rationale' SubClassOf 'Rationale'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185635</classIRI>
<classLabel>49,XXXXY Syndrome</classLabel>
<newAxiom>'49,XXXXY Syndrome' SubClassOf 'Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185638</classIRI>
<classLabel>Ring Chromosome 14 Syndrome</classLabel>
<newAxiom>'Ring Chromosome 14 Syndrome' SubClassOf 'Syndrome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185637</classIRI>
<classLabel>Clinical Indication</classLabel>
<newAxiom>'Clinical Indication' SubClassOf 'Indication'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185639</classIRI>
<classLabel>Canine Oral Melanoma</classLabel>
<newAxiom>'Canine Oral Melanoma' SubClassOf 'Canine Melanoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185621</classIRI>
<classLabel>Immunohistochemistry Test Result Unit</classLabel>
<newAxiom>'Immunohistochemistry Test Result Unit' SubClassOf 'Unit of Biological and Biochemical Measurement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185620</classIRI>
<classLabel>Insulin-Like Growth Factor-Binding Protein Complex Acid Labile Subunit</classLabel>
<newAxiom>'Insulin-Like Growth Factor-Binding Protein Complex Acid Labile Subunit' EquivalentTo 'Insulin-Like Growth Factor-Binding Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Extracellular Space') and ('Gene_Product_Expressed_In_Tissue' some 'Plasma') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Leucine-Rich Repeat') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Intercellular Communication Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transport Process') and ('Gene_Product_Encoded_By_Gene' some 'IGFALS Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185623</classIRI>
<classLabel>qPET Score</classLabel>
<newAxiom>'qPET Score' SubClassOf 'Score'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185622</classIRI>
<classLabel>Age in Days at Imaging</classLabel>
<newAxiom>'Age in Days at Imaging' SubClassOf 'Age-Days'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185625</classIRI>
<classLabel>Function Category</classLabel>
<newAxiom>'Function Category' SubClassOf 'Category'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185624</classIRI>
<classLabel>Age in Days at Function Test</classLabel>
<newAxiom>'Age in Days at Function Test' SubClassOf 'Age-Days'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185627</classIRI>
<classLabel>RASAL1 wt Allele</classLabel>
<newAxiom>'RASAL1 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '12q24.13'</newAxiom>
<newAxiom>'RASAL1 wt Allele' SubClassOf 'RASAL1 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185626</classIRI>
<classLabel>RASAL1 Gene</classLabel>
<newAxiom>'RASAL1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Calcium Binding'</newAxiom>
<newAxiom>'RASAL1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction Inhibition'</newAxiom>
<newAxiom>'RASAL1 Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185629</classIRI>
<classLabel>Numeric Function Test Result</classLabel>
<newAxiom>'Numeric Function Test Result' SubClassOf 'Numeric Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185628</classIRI>
<classLabel>RasGAP-Activating-Like Protein 1</classLabel>
<newAxiom>'RasGAP-Activating-Like Protein 1' EquivalentTo 'GTPase-Activating Protein' and 'Calcium Binding Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Cytosol') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'PH Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'C2 Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Calcium Binding') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction Inhibition') and ('Gene_Product_Encoded_By_Gene' some 'RASAL1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185619</classIRI>
<classLabel>IGFALS wt Allele</classLabel>
<newAxiom>'IGFALS wt Allele' SubClassOf 'IGFALS Gene'</newAxiom>
<newAxiom>'IGFALS wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '16p13.3'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185610</classIRI>
<classLabel>Neurogenic Differentiation Factor 4</classLabel>
<newAxiom>'Neurogenic Differentiation Factor 4' EquivalentTo 'Transcription Factor' and ('Gene_Product_Has_Chemical_Classification' some 'BHLH Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleus') and ('Gene_Product_Expressed_In_Tissue' some 'Retina') and ('Gene_Product_Expressed_In_Tissue' some 'Pituitary Gland') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'bHLH Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Sequence-Specific DNA Binding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Activation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'DNA Binding') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Neural Development') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Eye Development') and ('Gene_Product_Encoded_By_Gene' some 'NEUROD4 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185612</classIRI>
<classLabel>SHP2 Inhibitor</classLabel>
<newAxiom>'SHP2 Inhibitor' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185611</classIRI>
<classLabel>Blasts Greater than or Equal to 5000 per mL</classLabel>
<newAxiom>'Blasts Greater than or Equal to 5000 per mL' SubClassOf 'Blast Cells Present'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185614</classIRI>
<classLabel>Curative Therapy</classLabel>
<newAxiom>'Curative Therapy' SubClassOf 'Therapeutic Procedure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185613</classIRI>
<classLabel>USP1 inhibitor KSQ-4279</classLabel>
<newAxiom>'USP1 inhibitor KSQ-4279' SubClassOf 'Proteasome Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185616</classIRI>
<classLabel>FAM72A wt Allele</classLabel>
<newAxiom>'FAM72A wt Allele' SubClassOf 'FAM72A Gene'</newAxiom>
<newAxiom>'FAM72A wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '1q32.1'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185615</classIRI>
<classLabel>FAM72A Gene</classLabel>
<newAxiom>'FAM72A Gene' SubClassOf 'Regulatory Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185618</classIRI>
<classLabel>IGFALS Gene</classLabel>
<newAxiom>'IGFALS Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transport Process'</newAxiom>
<newAxiom>'IGFALS Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Intercellular Communication Process'</newAxiom>
<newAxiom>'IGFALS Gene' SubClassOf 'Transport Protein Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185617</classIRI>
<classLabel>Protein FAM72A</classLabel>
<newAxiom>'Protein FAM72A' SubClassOf 'Regulatory Protein'</newAxiom>
<newAxiom>'Protein FAM72A' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'FAM72A Gene'</newAxiom>
<newAxiom>'Protein FAM72A' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Mitochondrion'</newAxiom>
<newAxiom>'Protein FAM72A' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185609</classIRI>
<classLabel>NEUROD4 wt Allele</classLabel>
<newAxiom>'NEUROD4 wt Allele' SubClassOf 'NEUROD4 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185608</classIRI>
<classLabel>NEUROD4 Gene</classLabel>
<newAxiom>'NEUROD4 Gene' SubClassOf 'Transcription Factor Gene'</newAxiom>
<newAxiom>'NEUROD4 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Eye Development'</newAxiom>
<newAxiom>'NEUROD4 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'DNA Binding'</newAxiom>
<newAxiom>'NEUROD4 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Neural Development'</newAxiom>
<newAxiom>'NEUROD4 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Activation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185601</classIRI>
<classLabel>NEUROD2 Gene</classLabel>
<newAxiom>'NEUROD2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'DNA Binding'</newAxiom>
<newAxiom>'NEUROD2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Neural Development'</newAxiom>
<newAxiom>'NEUROD2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Activation'</newAxiom>
<newAxiom>'NEUROD2 Gene' SubClassOf 'Transcription Factor Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185600</classIRI>
<classLabel>Anti-HER2/Anti-PD-1 Bispecific Antibody SSGJ-705</classLabel>
<newAxiom>'Anti-HER2/Anti-PD-1 Bispecific Antibody SSGJ-705' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-HER2/Anti-PD-1 Bispecific Antibody SSGJ-705' SubClassOf 'Immune Checkpoint Inhibitor'</newAxiom>
<newAxiom>'Anti-HER2/Anti-PD-1 Bispecific Antibody SSGJ-705' SubClassOf 'Bispecific Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185603</classIRI>
<classLabel>NEUROD2 wt Allele</classLabel>
<newAxiom>'NEUROD2 wt Allele' SubClassOf 'NEUROD2 Gene'</newAxiom>
<newAxiom>'NEUROD2 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '17q12'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185602</classIRI>
<classLabel>Anti-CD3/Anti-Claudin18.2 Bispecific Antibody IBI389</classLabel>
<newAxiom>'Anti-CD3/Anti-Claudin18.2 Bispecific Antibody IBI389' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-CD3/Anti-Claudin18.2 Bispecific Antibody IBI389' SubClassOf 'Bispecific Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185605</classIRI>
<classLabel>Anti-PD-L1/Anti-CD47 Bispecific Antibody BAT7104</classLabel>
<newAxiom>'Anti-PD-L1/Anti-CD47 Bispecific Antibody BAT7104' SubClassOf 'Bispecific Antibody'</newAxiom>
<newAxiom>'Anti-PD-L1/Anti-CD47 Bispecific Antibody BAT7104' SubClassOf 'Antineoplastic Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185604</classIRI>
<classLabel>Neurogenic Differentiation Factor 2</classLabel>
<newAxiom>'Neurogenic Differentiation Factor 2' EquivalentTo 'Transcription Factor' and ('Gene_Product_Has_Chemical_Classification' some 'BHLH Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleus') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'bHLH Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Sequence-Specific DNA Binding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Activation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'DNA Binding') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Neural Development') and ('Gene_Product_Encoded_By_Gene' some 'NEUROD2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185607</classIRI>
<classLabel>Anti-Claudin18.2 CAR T Cells IBI345</classLabel>
<newAxiom>'Anti-Claudin18.2 CAR T Cells IBI345' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Anti-Claudin18.2 CAR T Cells IBI345' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185606</classIRI>
<classLabel>Multi-kinase Inhibitor T-1301</classLabel>
<newAxiom>'Multi-kinase Inhibitor T-1301' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185692</classIRI>
<classLabel>Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF1</classLabel>
<newAxiom>'Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF1' EquivalentTo 'Adaptor Signaling Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'Pathogenic Escherichia coli Infection Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Tight Junction Assembly Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'PDGFR-beta Signaling Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Thromboxane A2 Receptor Family Signaling Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoskeleton') and ('Gene_Product_Has_Associated_Anatomy' some 'Cellular Membrane') and ('Gene_Product_Has_Biochemical_Function' some 'Scaffolding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Regulation of Cell Shape') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Regulation of Cell Size') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'G Protein-Coupled Receptor Signaling') and ('Gene_Product_Encoded_By_Gene' some 'SLC9A3R1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185691</classIRI>
<classLabel>CTCAE Version</classLabel>
<newAxiom>'CTCAE Version' SubClassOf 'Adverse Event System Version'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185694</classIRI>
<classLabel>SMN Relationship to Radiation Field</classLabel>
<newAxiom>'SMN Relationship to Radiation Field' SubClassOf 'Location'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185693</classIRI>
<classLabel>Toxicity Details</classLabel>
<newAxiom>'Toxicity Details' SubClassOf 'Details'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185696</classIRI>
<classLabel>Musculoskeletal Hypoplasia</classLabel>
<newAxiom>'Musculoskeletal Hypoplasia' SubClassOf 'Musculoskeletal Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185695</classIRI>
<classLabel>Margin of XRT Field</classLabel>
<newAxiom>'Margin of XRT Field' SubClassOf 'Tumor Margin Configuration'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185698</classIRI>
<classLabel>APTX wt Allele</classLabel>
<newAxiom>'APTX wt Allele' SubClassOf 'APTX Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185697</classIRI>
<classLabel>APTX Gene</classLabel>
<newAxiom>'APTX Gene' SubClassOf 'DNA Repair Gene'</newAxiom>
<newAxiom>'APTX Gene' SubClassOf 'Hydrolase Gene'</newAxiom>
<newAxiom>'APTX Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Nucleotide Metabolic Process'</newAxiom>
<newAxiom>'APTX Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'DNA Binding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185699</classIRI>
<classLabel>Aprataxin</classLabel>
<newAxiom>'Aprataxin' EquivalentTo 'Hydrolase' and 'DNA Repair Protein' and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleolus') and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleus') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'C2H2 Zinc Finger') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'FHA Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Nuclear Localization Signal') and ('Gene_Product_Has_Biochemical_Function' some 'DNA Binding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'DNA Binding') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Nucleotide Metabolic Process') and ('Gene_Product_Encoded_By_Gene' some 'APTX Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185690</classIRI>
<classLabel>SLC9A3R1 wt Allele</classLabel>
<newAxiom>'SLC9A3R1 wt Allele' EquivalentTo 'SLC9A3R1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Pathogenic Escherichia coli Infection Pathway') and ('Gene_Is_Element_In_Pathway' some 'Tight Junction Assembly Pathway') and ('Gene_Is_Element_In_Pathway' some 'PDGFR-beta Signaling Pathway') and ('Gene_Is_Element_In_Pathway' some 'Thromboxane A2 Receptor Family Signaling Pathway') and ('Gene_In_Chromosomal_Location' some '17q25.1')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185681</classIRI>
<classLabel>GAD2 Gene</classLabel>
<newAxiom>'GAD2 Gene' SubClassOf 'Lyase Gene'</newAxiom>
<newAxiom>'GAD2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Neuronal Transmission'</newAxiom>
<newAxiom>'GAD2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Biogenic Amine Metabolic Process'</newAxiom>
<newAxiom>'GAD2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Biosynthetic Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185680</classIRI>
<classLabel>Glutamate Decarboxylase 1</classLabel>
<newAxiom>'Glutamate Decarboxylase 1' EquivalentTo 'Lyase' and ('Gene_Product_Is_Element_In_Pathway' some 'Beta-Alanine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Butanoate Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Taurine and Hypotaurine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Alanine, Aspartate and Glutamate Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Type I Diabetes Mellitus Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Fc-Epsilon Receptor I Signaling Pathway PID') and ('Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane') and ('Gene_Product_Malfunction_Associated_With_Disease' some 'Hepatoerythropoietic Porphyria') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Biosynthetic Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Neuronal Transmission') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Biogenic Amine Metabolic Process') and ('Gene_Product_Encoded_By_Gene' some 'GAD1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185683</classIRI>
<classLabel>Glutamate Decarboxylase 2</classLabel>
<newAxiom>'Glutamate Decarboxylase 2' EquivalentTo 'Lyase' and ('Gene_Product_Is_Element_In_Pathway' some 'Beta-Alanine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Butanoate Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Taurine and Hypotaurine Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Alanine, Aspartate and Glutamate Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Type I Diabetes Mellitus Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane') and ('Gene_Product_Has_Associated_Anatomy' some 'Membrane of the Golgi Apparatus') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytosol') and ('Gene_Product_Malfunction_Associated_With_Disease' some 'Hepatoerythropoietic Porphyria') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Biosynthetic Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Neuronal Transmission') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Biogenic Amine Metabolic Process') and ('Gene_Product_Encoded_By_Gene' some 'GAD2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185682</classIRI>
<classLabel>GAD2 wt Allele</classLabel>
<newAxiom>'GAD2 wt Allele' EquivalentTo 'GAD2 Gene' and ('Gene_Is_Element_In_Pathway' some 'Beta-Alanine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Butanoate Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Taurine and Hypotaurine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Alanine, Aspartate and Glutamate Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Type I Diabetes Mellitus Pathway') and ('Gene_In_Chromosomal_Location' some '10p12.1')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185685</classIRI>
<classLabel>Confirmed Germ Cell Failure</classLabel>
<newAxiom>'Confirmed Germ Cell Failure' SubClassOf 'Clinical Findings Indicator'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185684</classIRI>
<classLabel>Suspected Germ Cell Failure</classLabel>
<newAxiom>'Suspected Germ Cell Failure' SubClassOf 'Clinical Findings Indicator'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185687</classIRI>
<classLabel>SLC9A3R1 Gene</classLabel>
<newAxiom>'SLC9A3R1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'SLC9A3R1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'G Protein-Coupled Receptor Signaling'</newAxiom>
<newAxiom>'SLC9A3R1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Regulation of Cell Shape'</newAxiom>
<newAxiom>'SLC9A3R1 Gene' SubClassOf 'Adaptor Signaling Protein Gene'</newAxiom>
<newAxiom>'SLC9A3R1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Regulation of Cell Size'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185686</classIRI>
<classLabel>Late Effects Details</classLabel>
<newAxiom>'Late Effects Details' SubClassOf 'Details'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185689</classIRI>
<classLabel>Renal Tubule Damage</classLabel>
<newAxiom>'Renal Tubule Damage' SubClassOf 'Urinary System Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185688</classIRI>
<classLabel>Gastrointestinal Adhesion</classLabel>
<newAxiom>'Gastrointestinal Adhesion' SubClassOf 'Digestive System Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185670</classIRI>
<classLabel>Age in Days at Late Effect Evaluation</classLabel>
<newAxiom>'Age in Days at Late Effect Evaluation' SubClassOf 'Age-Days'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185672</classIRI>
<classLabel>Lower Age Range of Child Rater</classLabel>
<newAxiom>'Lower Age Range of Child Rater' SubClassOf 'Range'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185671</classIRI>
<classLabel>Decreased Creatinine Clearance</classLabel>
<newAxiom>'Decreased Creatinine Clearance' SubClassOf 'Abnormal Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185674</classIRI>
<classLabel>Health Utility Scale</classLabel>
<newAxiom>'Health Utility Scale' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185673</classIRI>
<classLabel>Upper Age Range of Child Rater</classLabel>
<newAxiom>'Upper Age Range of Child Rater' SubClassOf 'Range'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185676</classIRI>
<classLabel>GAD1 Gene</classLabel>
<newAxiom>'GAD1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Neuronal Transmission'</newAxiom>
<newAxiom>'GAD1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Biogenic Amine Metabolic Process'</newAxiom>
<newAxiom>'GAD1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Biosynthetic Process'</newAxiom>
<newAxiom>'GAD1 Gene' SubClassOf 'Lyase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185675</classIRI>
<classLabel>Wee1 Kinase Inhibitor IMP7068</classLabel>
<newAxiom>'Wee1 Kinase Inhibitor IMP7068' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'Wee1 Kinase Inhibitor IMP7068' SubClassOf 'Tyrosine Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185678</classIRI>
<classLabel>GAD1 wt Allele</classLabel>
<newAxiom>'GAD1 wt Allele' EquivalentTo 'GAD1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Beta-Alanine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Butanoate Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Taurine and Hypotaurine Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Alanine, Aspartate and Glutamate Metabolism Pathway') and ('Gene_Is_Element_In_Pathway' some 'Type I Diabetes Mellitus Pathway') and ('Gene_Is_Element_In_Pathway' some 'Fc-Epsilon Receptor I Signaling Pathway PID') and ('Gene_In_Chromosomal_Location' some '2q31.1')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185677</classIRI>
<classLabel>Anti-FLT3/CD3 Bispecific Antibody CLN-049</classLabel>
<newAxiom>'Anti-FLT3/CD3 Bispecific Antibody CLN-049' SubClassOf 'Flt-3-targeting Agent'</newAxiom>
<newAxiom>'Anti-FLT3/CD3 Bispecific Antibody CLN-049' SubClassOf 'Bispecific Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185679</classIRI>
<classLabel>Radiation Boost Dose</classLabel>
<newAxiom>'Radiation Boost Dose' SubClassOf 'Dose'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185661</classIRI>
<classLabel>Immune Related Adverse Event</classLabel>
<newAxiom>'Immune Related Adverse Event' SubClassOf 'Adverse Event'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185660</classIRI>
<classLabel>Palpable Lymph Node</classLabel>
<newAxiom>'Palpable Lymph Node' SubClassOf 'Lymph Node Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185663</classIRI>
<classLabel>Infusion Related Adverse Event</classLabel>
<newAxiom>'Infusion Related Adverse Event' SubClassOf 'Adverse Event by Type'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185662</classIRI>
<classLabel>MCPyV Negative</classLabel>
<newAxiom>'MCPyV Negative' SubClassOf 'Negative Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185665</classIRI>
<classLabel>Adverse Event Pathogen</classLabel>
<newAxiom>'Adverse Event Pathogen' SubClassOf 'General Qualifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185664</classIRI>
<classLabel>Anti-PSMA/CD3 Bispecific Antibody REGN4336</classLabel>
<newAxiom>'Anti-PSMA/CD3 Bispecific Antibody REGN4336' SubClassOf 'Bispecific Monoclonal Antibody'</newAxiom>
<newAxiom>'Anti-PSMA/CD3 Bispecific Antibody REGN4336' SubClassOf 'PSMA-targeting Agent'</newAxiom>
<newAxiom>'Anti-PSMA/CD3 Bispecific Antibody REGN4336' SubClassOf 'Antineoplastic Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185667</classIRI>
<classLabel>USP1 wt Allele</classLabel>
<newAxiom>'USP1 wt Allele' SubClassOf 'USP1 Gene'</newAxiom>
<newAxiom>'USP1 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '1p31.3'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185666</classIRI>
<classLabel>USP1 Gene</classLabel>
<newAxiom>'USP1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'DNA Repair Inhibition'</newAxiom>
<newAxiom>'USP1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Protein Cleavage'</newAxiom>
<newAxiom>'USP1 Gene' SubClassOf 'Cysteine Peptidase Gene'</newAxiom>
<newAxiom>'USP1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Protein Degradation Inhibition'</newAxiom>
<newAxiom>'USP1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Deubiquitination'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185669</classIRI>
<classLabel>Adverse Event Reported</classLabel>
<newAxiom>'Adverse Event Reported' SubClassOf 'Protocol Event'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185668</classIRI>
<classLabel>Ubiquitin Carboxyl-Terminal Hydrolase 1</classLabel>
<newAxiom>'Ubiquitin Carboxyl-Terminal Hydrolase 1' EquivalentTo 'Cysteine Proteinase' and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleus') and ('Gene_Product_Has_Biochemical_Function' some 'Ubiquitin C-Terminal Hydrolase') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Deubiquitination') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'DNA Repair Inhibition') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Protein Degradation Inhibition') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Protein Cleavage') and ('Gene_Product_Encoded_By_Gene' some 'USP1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185650</classIRI>
<classLabel>Original Agent</classLabel>
<newAxiom>'Original Agent' SubClassOf 'Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185652</classIRI>
<classLabel>Non-Corticosteroid Immunosuppressive Agent</classLabel>
<newAxiom>'Non-Corticosteroid Immunosuppressive Agent' SubClassOf 'Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185651</classIRI>
<classLabel>Straining</classLabel>
<newAxiom>'Straining' SubClassOf 'Action'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185654</classIRI>
<classLabel>Adverse Event Prevention</classLabel>
<newAxiom>'Adverse Event Prevention' SubClassOf 'Preventive Intervention'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185653</classIRI>
<classLabel>Reason for Medication Administration</classLabel>
<newAxiom>'Reason for Medication Administration' SubClassOf 'Reason'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185656</classIRI>
<classLabel>Number of Units of Product Transfused</classLabel>
<newAxiom>'Number of Units of Product Transfused' SubClassOf 'Number'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185655</classIRI>
<classLabel>Transfusion Product Processing</classLabel>
<newAxiom>'Transfusion Product Processing' SubClassOf 'Processing'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185658</classIRI>
<classLabel>Rapid Early Response</classLabel>
<newAxiom>'Rapid Early Response' SubClassOf 'Disease Response'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185657</classIRI>
<classLabel>Interim Response</classLabel>
<newAxiom>'Interim Response' SubClassOf 'Disease Response'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185659</classIRI>
<classLabel>Slow Early Response</classLabel>
<newAxiom>'Slow Early Response' SubClassOf 'Disease Response'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185719</classIRI>
<classLabel>Zinc Finger Protein 638</classLabel>
<newAxiom>'Zinc Finger Protein 638' EquivalentTo 'Transcription Factor' and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'C2H2 Zinc Finger') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'RNA Recognition Motif') and ('Gene_Product_Has_Biochemical_Function' some 'Sequence-Specific DNA Binding Protein') and ('Gene_Product_Has_Biochemical_Function' some 'RNA Binding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Repression') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Tissue-Specific Splicing') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'RNA Binding') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Adipogenesis') and ('Gene_Product_Encoded_By_Gene' some 'ZNF638 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185718</classIRI>
<classLabel>ZNF638 wt Allele</classLabel>
<newAxiom>'ZNF638 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '2p13.2'</newAxiom>
<newAxiom>'ZNF638 wt Allele' SubClassOf 'ZNF638 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185711</classIRI>
<classLabel>MPHOSPH10 wt Allele</classLabel>
<newAxiom>'MPHOSPH10 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Ribosomal Biogenesis Pathway'</newAxiom>
<newAxiom>'MPHOSPH10 wt Allele' SubClassOf 'MPHOSPH10 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185710</classIRI>
<classLabel>MPHOSPH10 Gene</classLabel>
<newAxiom>'MPHOSPH10 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'RNA Processing'</newAxiom>
<newAxiom>'MPHOSPH10 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'RNA Splicing'</newAxiom>
<newAxiom>'MPHOSPH10 Gene' SubClassOf 'Ligand Binding Protein Gene'</newAxiom>
<newAxiom>'MPHOSPH10 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'RNA Binding'</newAxiom>
<newAxiom>'MPHOSPH10 Gene' SubClassOf 'Translation Process Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185713</classIRI>
<classLabel>Neurotization Procedure</classLabel>
<newAxiom>'Neurotization Procedure' SubClassOf 'Therapeutic Procedure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185712</classIRI>
<classLabel>U3 Small Nucleolar Ribonucleoprotein Protein MPP10</classLabel>
<newAxiom>'U3 Small Nucleolar Ribonucleoprotein Protein MPP10' EquivalentTo 'RNA Binding Protein' and 'Translation Process Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'Ribosomal Biogenesis Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleolus') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'RNA Recognition Motif') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Coiled-Coil Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Ribonucleoprotein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'RNA Splicing') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'RNA Processing') and ('Gene_Product_Encoded_By_Gene' some 'MPHOSPH10 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185715</classIRI>
<classLabel>RALGAPB wt Allele</classLabel>
<newAxiom>'RALGAPB wt Allele' SubClassOf 'RALGAPB Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185714</classIRI>
<classLabel>RALGAPB Gene</classLabel>
<newAxiom>'RALGAPB Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'RALGAPB Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185717</classIRI>
<classLabel>ZNF638 Gene</classLabel>
<newAxiom>'ZNF638 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Tissue-Specific Splicing'</newAxiom>
<newAxiom>'ZNF638 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Adipogenesis'</newAxiom>
<newAxiom>'ZNF638 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Repression'</newAxiom>
<newAxiom>'ZNF638 Gene' SubClassOf 'Transcription Factor Gene'</newAxiom>
<newAxiom>'ZNF638 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'RNA Binding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185716</classIRI>
<classLabel>Ral GTPase-Activating Protein Subunit Beta</classLabel>
<newAxiom>'Ral GTPase-Activating Protein Subunit Beta' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'Ral GTPase-Activating Protein Subunit Beta' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'RALGAPB Gene'</newAxiom>
<newAxiom>'Ral GTPase-Activating Protein Subunit Beta' SubClassOf 'GTPase-Activating Protein'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185708</classIRI>
<classLabel>FRA10AC1 wt Allele</classLabel>
<newAxiom>'FRA10AC1 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '10q23.33'</newAxiom>
<newAxiom>'FRA10AC1 wt Allele' SubClassOf 'FRA10AC1 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185707</classIRI>
<classLabel>FRA10AC1 Gene</classLabel>
<newAxiom>'FRA10AC1 Gene' SubClassOf 'Regulatory Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185709</classIRI>
<classLabel>Protein FRA10AC1</classLabel>
<newAxiom>'Protein FRA10AC1' SubClassOf 'Gene_Product_Has_Chemical_Classification' some 'Nuclear Protein'</newAxiom>
<newAxiom>'Protein FRA10AC1' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'FRA10AC1 Gene'</newAxiom>
<newAxiom>'Protein FRA10AC1' SubClassOf 'Gene_Product_Has_Chemical_Classification' some 'Phosphoprotein'</newAxiom>
<newAxiom>'Protein FRA10AC1' SubClassOf 'Regulatory Protein'</newAxiom>
<newAxiom>'Protein FRA10AC1' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Nucleus'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185700</classIRI>
<classLabel>Raters Allowed to Report PRO</classLabel>
<newAxiom>'Raters Allowed to Report PRO' SubClassOf 'Property or Attribute'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185702</classIRI>
<classLabel>Subject and Parent/Guardian</classLabel>
<newAxiom>'Subject and Parent/Guardian' SubClassOf 'Responsible Person'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185701</classIRI>
<classLabel>Parent/Guardian</classLabel>
<newAxiom>'Parent/Guardian' SubClassOf 'Responsible Person'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185704</classIRI>
<classLabel>MED13 Gene</classLabel>
<newAxiom>'MED13 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Regulation'</newAxiom>
<newAxiom>'MED13 Gene' SubClassOf 'Mediator Complex Component Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185703</classIRI>
<classLabel>Follow-Up Assessment</classLabel>
<newAxiom>'Follow-Up Assessment' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185706</classIRI>
<classLabel>Mediator of RNA Polymerase II Transcription Subunit 13</classLabel>
<newAxiom>'Mediator of RNA Polymerase II Transcription Subunit 13' EquivalentTo 'Transcription Regulatory Protein' and ('Gene_Product_Is_Physical_Part_Of' some 'Mediator Complex') and ('Gene_Product_Has_Biochemical_Function' some 'Transcription Coactivator') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Regulation') and ('Gene_Product_Encoded_By_Gene' some 'MED13 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185705</classIRI>
<classLabel>MED13 wt Allele</classLabel>
<newAxiom>'MED13 wt Allele' SubClassOf 'MED13 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185494</classIRI>
<classLabel>Diameter Dimension 1 Orientation</classLabel>
<newAxiom>'Diameter Dimension 1 Orientation' SubClassOf 'Orientation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185493</classIRI>
<classLabel>Longest Diameter Dimension 3</classLabel>
<newAxiom>'Longest Diameter Dimension 3' SubClassOf 'Greatest Dimension Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185496</classIRI>
<classLabel>Diameter Dimension 3 Orientation</classLabel>
<newAxiom>'Diameter Dimension 3 Orientation' SubClassOf 'Orientation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185495</classIRI>
<classLabel>Diameter Dimension 2 Orientation</classLabel>
<newAxiom>'Diameter Dimension 2 Orientation' SubClassOf 'Orientation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185498</classIRI>
<classLabel>Hemoglobin E</classLabel>
<newAxiom>'Hemoglobin E' SubClassOf 'Gene_Product_Has_Abnormality' some 'HBB NP_000509.1:p.E27K'</newAxiom>
<newAxiom>'Hemoglobin E' SubClassOf 'Hemoglobin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185497</classIRI>
<classLabel>Lesion Percentage of Change</classLabel>
<newAxiom>'Lesion Percentage of Change' SubClassOf 'Percent Tumor Tissue'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185499</classIRI>
<classLabel>Hemoglobin H</classLabel>
<newAxiom>'Hemoglobin H' SubClassOf 'Hemoglobin'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185401</classIRI>
<classLabel>Anti-B7-H4/ TOP1i Antibody-drug Conjugate AZD8205</classLabel>
<newAxiom>'Anti-B7-H4/ TOP1i Antibody-drug Conjugate AZD8205' SubClassOf 'Antineoplastic Antibody-Drug Conjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185400</classIRI>
<classLabel>PSA Decline Greater than 90 Percent</classLabel>
<newAxiom>'PSA Decline Greater than 90 Percent' SubClassOf 'PSA Level Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185403</classIRI>
<classLabel>Buffered Formalin Fixation</classLabel>
<newAxiom>'Buffered Formalin Fixation' SubClassOf 'Fixation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185402</classIRI>
<classLabel>Unbuffered Formalin Fixation</classLabel>
<newAxiom>'Unbuffered Formalin Fixation' SubClassOf 'Fixation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185405</classIRI>
<classLabel>Fresh Dissociated Tissue Preparation, Single Cell Sorted</classLabel>
<newAxiom>'Fresh Dissociated Tissue Preparation, Single Cell Sorted' SubClassOf 'Tissue Preparation or Processing Technique'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185404</classIRI>
<classLabel>Fresh Dissociated Tissue Preparation</classLabel>
<newAxiom>'Fresh Dissociated Tissue Preparation' SubClassOf 'Tissue Preparation or Processing Technique'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185407</classIRI>
<classLabel>NKp46/CD16-based CD123-targeted NK Cell Engager SAR443579</classLabel>
<newAxiom>'NKp46/CD16-based CD123-targeted NK Cell Engager SAR443579' SubClassOf 'Antineoplastic Immunomodulating Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185406</classIRI>
<classLabel>Fresh Dissociated Tissue Preparation, Single Cell Sorted into Plates</classLabel>
<newAxiom>'Fresh Dissociated Tissue Preparation, Single Cell Sorted into Plates' SubClassOf 'Tissue Preparation or Processing Technique'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185409</classIRI>
<classLabel>Dulbecco's Modified Eagle Medium</classLabel>
<newAxiom>'Dulbecco's Modified Eagle Medium' SubClassOf 'Growth Medium'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185408</classIRI>
<classLabel>Cell Culture Serum</classLabel>
<newAxiom>'Cell Culture Serum' SubClassOf 'Reagent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185490</classIRI>
<classLabel>Longest Diameter Dimension 1</classLabel>
<newAxiom>'Longest Diameter Dimension 1' SubClassOf 'Greatest Dimension Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185492</classIRI>
<classLabel>Bacillus Calmette-Guerin Unresponsive Disease</classLabel>
<newAxiom>'Bacillus Calmette-Guerin Unresponsive Disease' SubClassOf 'Disease Response'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185491</classIRI>
<classLabel>Longest Diameter Dimension 2</classLabel>
<newAxiom>'Longest Diameter Dimension 2' SubClassOf 'Greatest Dimension Tumor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185483</classIRI>
<classLabel>Ann Arbor A Symptoms Indicator</classLabel>
<newAxiom>'Ann Arbor A Symptoms Indicator' SubClassOf 'Ann Arbor Staging Modifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185482</classIRI>
<classLabel>Intracytoplasmic Sperm Injection</classLabel>
<newAxiom>'Intracytoplasmic Sperm Injection' SubClassOf 'Reproductive Technique'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185485</classIRI>
<classLabel>Age in Days at Lesion Assessment</classLabel>
<newAxiom>'Age in Days at Lesion Assessment' SubClassOf 'Age-Days'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185484</classIRI>
<classLabel>Ann Arbor Splenic Involvement Modifier</classLabel>
<newAxiom>'Ann Arbor Splenic Involvement Modifier' SubClassOf 'Ann Arbor Staging Modifier'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185487</classIRI>
<classLabel>Pediatric Glioma RTK1 Molecular Signature Detected</classLabel>
<newAxiom>'Pediatric Glioma RTK1 Molecular Signature Detected' SubClassOf 'Biomarker Positive Malignant Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185486</classIRI>
<classLabel>Pediatric Glioma MYCN Molecular Signature Detected</classLabel>
<newAxiom>'Pediatric Glioma MYCN Molecular Signature Detected' SubClassOf 'Biomarker Positive Malignant Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185489</classIRI>
<classLabel>Lesion Classification</classLabel>
<newAxiom>'Lesion Classification' SubClassOf 'Classification'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185488</classIRI>
<classLabel>Pediatric Glioma RTK2 Molecular Signature Detected</classLabel>
<newAxiom>'Pediatric Glioma RTK2 Molecular Signature Detected' SubClassOf 'Biomarker Positive Malignant Neoplasm'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185481</classIRI>
<classLabel>Conceived Through Assisted Conception</classLabel>
<newAxiom>'Conceived Through Assisted Conception' SubClassOf 'Pregnancy Outcome'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185480</classIRI>
<classLabel>Tonation Breathing Technique</classLabel>
<newAxiom>'Tonation Breathing Technique' SubClassOf 'Mind-Body Intervention Procedure'</newAxiom>
<newAxiom>'Tonation Breathing Technique' SubClassOf 'Pain Therapy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185472</classIRI>
<classLabel>Infant-Type Hemispheric Glioma, NTRK-Altered</classLabel>
<newAxiom>'Infant-Type Hemispheric Glioma, NTRK-Altered' EquivalentTo 'Infant-Type Hemispheric Glioma' and ('Disease_Has_Finding' some 'NTRK Fusion Gene Positive')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185471</classIRI>
<classLabel>Infant-Type Hemispheric Glioma</classLabel>
<newAxiom>'Infant-Type Hemispheric Glioma' EquivalentTo 'Malignant Brain Glioma' and 'Malignant Cerebral Neoplasm' and 'Malignant Childhood Central Nervous System Neoplasm' and 'Childhood Supratentorial Neoplasm' and ('Disease_Has_Finding' some 'Increased Cellularity Present') and ('Disease_Is_Grade' some 'High Grade') and ('Disease_May_Have_Finding' some 'Necrotic Change')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185474</classIRI>
<classLabel>Infant-Type Hemispheric Glioma, ALK-Altered</classLabel>
<newAxiom>'Infant-Type Hemispheric Glioma, ALK-Altered' EquivalentTo 'Infant-Type Hemispheric Glioma' and ('Disease_Has_Finding' some 'ALK Fusion Gene Positive')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185473</classIRI>
<classLabel>Infant-Type Hemispheric Glioma, ROS1-Altered</classLabel>
<newAxiom>'Infant-Type Hemispheric Glioma, ROS1-Altered' EquivalentTo 'Infant-Type Hemispheric Glioma' and ('Disease_Has_Finding' some 'ROS1 Fusion Gene Positive')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185476</classIRI>
<classLabel>Bulky Nodal Disease</classLabel>
<newAxiom>'Bulky Nodal Disease' SubClassOf 'Bulky Disease'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185475</classIRI>
<classLabel>Infant-Type Hemispheric Glioma, MET-Altered</classLabel>
<newAxiom>'Infant-Type Hemispheric Glioma, MET-Altered' EquivalentTo 'Infant-Type Hemispheric Glioma' and ('Disease_Has_Finding' some 'MET Fusion Gene Positive')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185478</classIRI>
<classLabel>Extranodal Site of the Extended Lesion</classLabel>
<newAxiom>'Extranodal Site of the Extended Lesion' SubClassOf 'Disease Involvement Site'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185477</classIRI>
<classLabel>Bulky Lesion</classLabel>
<newAxiom>'Bulky Lesion' SubClassOf 'Bulky Disease'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185479</classIRI>
<classLabel>Lesion Laterality</classLabel>
<newAxiom>'Lesion Laterality' SubClassOf 'Laterality'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185470</classIRI>
<classLabel>Diffuse Pediatric-Type High Grade Glioma MYCN</classLabel>
<newAxiom>'Diffuse Pediatric-Type High Grade Glioma MYCN' EquivalentTo 'Diffuse Pediatric-Type High Grade Glioma, H3-Wildtype and IDH-Wildtype' and ('Disease_Has_Finding' some 'Pediatric Glioma MYCN Molecular Signature Detected')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185461</classIRI>
<classLabel>Heterozygous Anti-3.7 HBA Rearrangement</classLabel>
<newAxiom>'Heterozygous Anti-3.7 HBA Rearrangement' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'HBA2 Gene'</newAxiom>
<newAxiom>'Heterozygous Anti-3.7 HBA Rearrangement' SubClassOf 'Loss of Heterozygosity'</newAxiom>
<newAxiom>'Heterozygous Anti-3.7 HBA Rearrangement' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'HBA1 Gene'</newAxiom>
<newAxiom>'Heterozygous Anti-3.7 HBA Rearrangement' SubClassOf 'HBA Gene Rearrangement'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185460</classIRI>
<classLabel>Heterozygous HBA 3.7 kb Deletion</classLabel>
<newAxiom>'Heterozygous HBA 3.7 kb Deletion' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'HBA1 Gene'</newAxiom>
<newAxiom>'Heterozygous HBA 3.7 kb Deletion' SubClassOf 'Loss of Heterozygosity'</newAxiom>
<newAxiom>'Heterozygous HBA 3.7 kb Deletion' SubClassOf 'HBA Gene Rearrangement'</newAxiom>
<newAxiom>'Heterozygous HBA 3.7 kb Deletion' SubClassOf 'Chromosomal Deletion'</newAxiom>
<newAxiom>'Heterozygous HBA 3.7 kb Deletion' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'HBA2 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185463</classIRI>
<classLabel>Sodium Phosphate P-32, Unspecified</classLabel>
<newAxiom>'Sodium Phosphate P-32, Unspecified' SubClassOf 'Antineoplastic Radiopharmaceutical Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185462</classIRI>
<classLabel>Genital Tract Fistula</classLabel>
<newAxiom>'Genital Tract Fistula' SubClassOf 'Fistula'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185465</classIRI>
<classLabel>Zirconium Zr 89-DFO-YS5</classLabel>
<newAxiom>'Zirconium Zr 89-DFO-YS5' SubClassOf 'Radioimmunoconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185464</classIRI>
<classLabel>BRD4 Gene Amplification</classLabel>
<newAxiom>'BRD4 Gene Amplification' SubClassOf 'Gene Amplification Abnormality'</newAxiom>
<newAxiom>'BRD4 Gene Amplification' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'BRD4 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185467</classIRI>
<classLabel>Diffuse Pediatric-Type High Grade Glioma, H3-Wildtype and IDH-Wildtype</classLabel>
<newAxiom>'Diffuse Pediatric-Type High Grade Glioma, H3-Wildtype and IDH-Wildtype' EquivalentTo 'Diffuse Glioma' and 'Malignant Brain Glioma' and ('Disease_Is_Grade' some 'Grade 4') and ('Disease_Excludes_Molecular_Abnormality' some 'IDH Gene Family Mutation') and ('Disease_Excludes_Molecular_Abnormality' some 'Histone H3 Gene Mutation')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185466</classIRI>
<classLabel>Anti-CD46 Monoclonal Antibody YS5</classLabel>
<newAxiom>'Anti-CD46 Monoclonal Antibody YS5' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185469</classIRI>
<classLabel>Diffuse Pediatric-Type High Grade Glioma RTK1</classLabel>
<newAxiom>'Diffuse Pediatric-Type High Grade Glioma RTK1' EquivalentTo 'Diffuse Pediatric-Type High Grade Glioma, H3-Wildtype and IDH-Wildtype' and ('Disease_Has_Finding' some 'Pediatric Glioma RTK1 Molecular Signature Detected')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185468</classIRI>
<classLabel>Diffuse Pediatric-Type High Grade Glioma RTK2</classLabel>
<newAxiom>'Diffuse Pediatric-Type High Grade Glioma RTK2' EquivalentTo 'Diffuse Pediatric-Type High Grade Glioma, H3-Wildtype and IDH-Wildtype' and ('Disease_Has_Finding' some 'Pediatric Glioma RTK2 Molecular Signature Detected')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185450</classIRI>
<classLabel>V-Type Proton ATPase 116 kDa Subunit A3</classLabel>
<newAxiom>'V-Type Proton ATPase 116 kDa Subunit A3' EquivalentTo 'Ion Channel Protein' and ('Gene_Product_Is_Element_In_Pathway' some 'Oxidative Phosphorylation Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Lysosome Assembly Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Vibrio cholerae Infection Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Collecting Duct Acid Secretion Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Epithelial Cell Signaling Pathway in Helicobacter pylori Infection') and ('Gene_Product_Is_Element_In_Pathway' some 'Phagocytosis Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Cellular Membrane') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'ATP Hydrolysis') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Ion Transport Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Proton Pump Interaction') and ('Gene_Product_Encoded_By_Gene' some 'TCIRG1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185452</classIRI>
<classLabel>KLF1 Gene Mutation</classLabel>
<newAxiom>'KLF1 Gene Mutation' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'KLF1 Protein Variant'</newAxiom>
<newAxiom>'KLF1 Gene Mutation' SubClassOf 'Gene Variant'</newAxiom>
<newAxiom>'KLF1 Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'KLF1 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185451</classIRI>
<classLabel>Rectovaginal Septum</classLabel>
<newAxiom>'Rectovaginal Septum' SubClassOf 'Fascia'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185454</classIRI>
<classLabel>YAP/TEAD Interaction Inhibitor IAG933</classLabel>
<newAxiom>'YAP/TEAD Interaction Inhibitor IAG933' SubClassOf 'Signal Transduction Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185453</classIRI>
<classLabel>KLF1 Protein Variant</classLabel>
<newAxiom>'KLF1 Protein Variant' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'KLF1 Gene'</newAxiom>
<newAxiom>'KLF1 Protein Variant' SubClassOf 'Gene_Product_Variant_Of_Gene_Product' some 'Krueppel-Like Factor 1'</newAxiom>
<newAxiom>'KLF1 Protein Variant' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'KLF1 Gene Mutation'</newAxiom>
<newAxiom>'KLF1 Protein Variant' SubClassOf 'Gene Product Sequence Variation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185456</classIRI>
<classLabel>KLF1 NM_006563.5:c.115AC</classLabel>
<newAxiom>'KLF1 NM_006563.5:c.115AC' SubClassOf 'KLF1 Gene Mutation'</newAxiom>
<newAxiom>'KLF1 NM_006563.5:c.115AC' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'KLF1 NP_006554.1:p.M39L'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185455</classIRI>
<classLabel>KLF1 NM_006563.5:c.892GC</classLabel>
<newAxiom>'KLF1 NM_006563.5:c.892GC' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'KLF1 NP_006554.1:p.A298P'</newAxiom>
<newAxiom>'KLF1 NM_006563.5:c.892GC' SubClassOf 'KLF1 Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185458</classIRI>
<classLabel>KLF1 NP_006554.1:p.M39L</classLabel>
<newAxiom>'KLF1 NP_006554.1:p.M39L' SubClassOf 'KLF1 Protein Variant'</newAxiom>
<newAxiom>'KLF1 NP_006554.1:p.M39L' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'KLF1 NM_006563.5:c.115AC'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185457</classIRI>
<classLabel>KLF1 NP_006554.1:p.A298P</classLabel>
<newAxiom>'KLF1 NP_006554.1:p.A298P' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'KLF1 NM_006563.5:c.892GC'</newAxiom>
<newAxiom>'KLF1 NP_006554.1:p.A298P' SubClassOf 'KLF1 Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185459</classIRI>
<classLabel>HBA Gene Rearrangement</classLabel>
<newAxiom>'HBA Gene Rearrangement' SubClassOf 'Cytogenetic_Abnormality_Involves_Chromosome' some 'Chromosome 16'</newAxiom>
<newAxiom>'HBA Gene Rearrangement' SubClassOf 'Gene Rearrangement Abnormality'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185441</classIRI>
<classLabel>BCL11A NC_000002.12:g.60490908=</classLabel>
<newAxiom>'BCL11A NC_000002.12:g.60490908=' SubClassOf 'BCL11A Gene Mutation'</newAxiom>
<newAxiom>'BCL11A NC_000002.12:g.60490908=' SubClassOf 'Intronic Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185440</classIRI>
<classLabel>BCL11A Gene Mutation</classLabel>
<newAxiom>'BCL11A Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'BCL11A Gene'</newAxiom>
<newAxiom>'BCL11A Gene Mutation' SubClassOf 'Gene Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185443</classIRI>
<classLabel>TCIRG1 Gene Mutation</classLabel>
<newAxiom>'TCIRG1 Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'TCIRG1 Gene'</newAxiom>
<newAxiom>'TCIRG1 Gene Mutation' SubClassOf 'Gene Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185442</classIRI>
<classLabel>BCL11A NC_000002.12:g.60486100AG</classLabel>
<newAxiom>'BCL11A NC_000002.12:g.60486100AG' SubClassOf 'Intronic Mutation'</newAxiom>
<newAxiom>'BCL11A NC_000002.12:g.60486100AG' SubClassOf 'BCL11A Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185445</classIRI>
<classLabel>Autologous CD34+-enriched HSPCs Transduced with LV Vector Carrying TCIRG1 Gene RP-L401</classLabel>
<newAxiom>'Autologous CD34+-enriched HSPCs Transduced with LV Vector Carrying TCIRG1 Gene RP-L401' SubClassOf 'Gene Therapy Agent'</newAxiom>
<newAxiom>'Autologous CD34+-enriched HSPCs Transduced with LV Vector Carrying TCIRG1 Gene RP-L401' SubClassOf 'Adoptive Cell Therapy Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185444</classIRI>
<classLabel>Ipsilateral Peripheral Intravenous Catheter Insertion</classLabel>
<newAxiom>'Ipsilateral Peripheral Intravenous Catheter Insertion' SubClassOf 'Catheterization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185446</classIRI>
<classLabel>NC_000006.12:g.135097497_135097499del</classLabel>
<newAxiom>'NC_000006.12:g.135097497_135097499del' SubClassOf 'Deletion Mutation'</newAxiom>
<newAxiom>'NC_000006.12:g.135097497_135097499del' SubClassOf 'Intergenic Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185449</classIRI>
<classLabel>TCIRG1 wt Allele</classLabel>
<newAxiom>'TCIRG1 wt Allele' EquivalentTo 'TCIRG1 Gene' and ('Gene_Is_Element_In_Pathway' some 'Oxidative Phosphorylation Pathway') and ('Gene_Is_Element_In_Pathway' some 'Lysosome Assembly Pathway') and ('Gene_Is_Element_In_Pathway' some 'Vibrio cholerae Infection Pathway') and ('Gene_Is_Element_In_Pathway' some 'Collecting Duct Acid Secretion Pathway') and ('Gene_Is_Element_In_Pathway' some 'Epithelial Cell Signaling Pathway in Helicobacter pylori Infection') and ('Gene_Is_Element_In_Pathway' some 'Phagocytosis Pathway') and ('Gene_In_Chromosomal_Location' some '11q13.2')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185448</classIRI>
<classLabel>TCIRG1 Gene</classLabel>
<newAxiom>'TCIRG1 Gene' SubClassOf 'Ion Channel Protein Gene'</newAxiom>
<newAxiom>'TCIRG1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'ATP Hydrolysis'</newAxiom>
<newAxiom>'TCIRG1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Proton Pump Interaction'</newAxiom>
<newAxiom>'TCIRG1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Ion Transport Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185430</classIRI>
<classLabel>Antibody-drug Conjugate TORL-1-23</classLabel>
<newAxiom>'Antibody-drug Conjugate TORL-1-23' SubClassOf 'Antineoplastic Antibody-Drug Conjugate'</newAxiom>
<newAxiom>'Antibody-drug Conjugate TORL-1-23' SubClassOf 'Immunoconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185432</classIRI>
<classLabel>Sexually Active</classLabel>
<newAxiom>'Sexually Active' SubClassOf 'Sexual Activity Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185431</classIRI>
<classLabel>Liver Cancer Neoantigens-sensitized Autoimmune Cells IPM001</classLabel>
<newAxiom>'Liver Cancer Neoantigens-sensitized Autoimmune Cells IPM001' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185434</classIRI>
<classLabel>Thalassemic Osteopathy</classLabel>
<newAxiom>'Thalassemic Osteopathy' SubClassOf 'Non-Neoplastic Bone Disorder'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185433</classIRI>
<classLabel>Sexual Relations</classLabel>
<newAxiom>'Sexual Relations' SubClassOf 'Sex Behavior'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185436</classIRI>
<classLabel>Cyclomethycaine Sulfate</classLabel>
<newAxiom>'Cyclomethycaine Sulfate' SubClassOf 'Anesthetic Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185435</classIRI>
<classLabel>Topotecan Hydrochloride (1:1.25)</classLabel>
<newAxiom>'Topotecan Hydrochloride (1:1.25)' SubClassOf 'Camptothecin Analogue'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185438</classIRI>
<classLabel>HBG2 Gene Mutation</classLabel>
<newAxiom>'HBG2 Gene Mutation' SubClassOf 'Gene Variant'</newAxiom>
<newAxiom>'HBG2 Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'HBG2 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185437</classIRI>
<classLabel>Smoothened Antagonist CUR-61414</classLabel>
<newAxiom>'Smoothened Antagonist CUR-61414' SubClassOf 'Smoothened Antagonist'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185439</classIRI>
<classLabel>HBG2 NM_000184.2:c.-211CT</classLabel>
<newAxiom>'HBG2 NM_000184.2:c.-211CT' SubClassOf 'HBG2 Gene Mutation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185421</classIRI>
<classLabel>PI3K-gamma Inhibitor ZX-4081</classLabel>
<newAxiom>'PI3K-gamma Inhibitor ZX-4081' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'PI3K-gamma Inhibitor ZX-4081' SubClassOf 'Phosphatidylinositide 3-Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185420</classIRI>
<classLabel>SETD2 Inhibitor EZM0414</classLabel>
<newAxiom>'SETD2 Inhibitor EZM0414' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185423</classIRI>
<classLabel>KALRN Gene</classLabel>
<newAxiom>'KALRN Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transport Process'</newAxiom>
<newAxiom>'KALRN Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
<newAxiom>'KALRN Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'G Protein-Coupled Receptor Signaling'</newAxiom>
<newAxiom>'KALRN Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
<newAxiom>'KALRN Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'KALRN Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Nervous System Development'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185422</classIRI>
<classLabel>ROS1 Inhibitor NVL-520</classLabel>
<newAxiom>'ROS1 Inhibitor NVL-520' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185425</classIRI>
<classLabel>Anti-PD-1/TGFbRII Fusion Protein LBL-015</classLabel>
<newAxiom>'Anti-PD-1/TGFbRII Fusion Protein LBL-015' SubClassOf 'Antineoplastic Immunomodulating Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185424</classIRI>
<classLabel>KALRN wt Allele</classLabel>
<newAxiom>'KALRN wt Allele' SubClassOf 'KALRN Gene'</newAxiom>
<newAxiom>'KALRN wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Arf6 Signaling Pathway'</newAxiom>
<newAxiom>'KALRN wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Ephrin B Forward Signaling Pathway'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185427</classIRI>
<classLabel>Kalirin</classLabel>
<newAxiom>'Kalirin' EquivalentTo 'Serine/Threonine Protein Kinase' and 'Guanine Nucleotide Exchange Factor' and ('Gene_Product_Is_Element_In_Pathway' some 'Arf6 Signaling Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Ephrin B Forward Signaling Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoskeleton') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'SH3 Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'DH Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'PH Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Immunoglobulin-Like C2-Type Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transport Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'G Protein-Coupled Receptor Signaling') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Nervous System Development') and ('Gene_Product_Encoded_By_Gene' some 'KALRN Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185426</classIRI>
<classLabel>Anti-PD-L1/TGFbetaRII Fusion Protein BJ-005</classLabel>
<newAxiom>'Anti-PD-L1/TGFbetaRII Fusion Protein BJ-005' SubClassOf 'Antineoplastic Immunomodulating Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185429</classIRI>
<classLabel>Autologous Interleukin-15-armored Anti-glypican-3 CAR-iC9-expressing T-lymphocytes</classLabel>
<newAxiom>'Autologous Interleukin-15-armored Anti-glypican-3 CAR-iC9-expressing T-lymphocytes' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Autologous Interleukin-15-armored Anti-glypican-3 CAR-iC9-expressing T-lymphocytes' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
<newAxiom>'Autologous Interleukin-15-armored Anti-glypican-3 CAR-iC9-expressing T-lymphocytes' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185428</classIRI>
<classLabel>Kinase Inhibitor UCT-03-008</classLabel>
<newAxiom>'Kinase Inhibitor UCT-03-008' SubClassOf 'Protein Kinase Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185410</classIRI>
<classLabel>CIT Gene</classLabel>
<newAxiom>'CIT Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cytokinesis'</newAxiom>
<newAxiom>'CIT Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Mitosis'</newAxiom>
<newAxiom>'CIT Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
<newAxiom>'CIT Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Serine/Threonine Phosphorylation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185412</classIRI>
<classLabel>Citron Rho-Interacting Kinase</classLabel>
<newAxiom>'Citron Rho-Interacting Kinase' EquivalentTo 'Serine/Threonine Protein Kinase' and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoskeleton') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytosol') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'PH Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'DAG/PE-Binding Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'SH3-Binding Motif') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cytokinesis') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Mitosis') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Serine/Threonine Phosphorylation') and ('Gene_Product_Encoded_By_Gene' some 'CIT Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185411</classIRI>
<classLabel>CIT wt Allele</classLabel>
<newAxiom>'CIT wt Allele' SubClassOf 'CIT Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185414</classIRI>
<classLabel>OBSCN Gene</classLabel>
<newAxiom>'OBSCN Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
<newAxiom>'OBSCN Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'G Protein-Coupled Receptor Signaling'</newAxiom>
<newAxiom>'OBSCN Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Myogenesis'</newAxiom>
<newAxiom>'OBSCN Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
<newAxiom>'OBSCN Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185413</classIRI>
<classLabel>Antibody-drug Conjugate SHR-A1912</classLabel>
<newAxiom>'Antibody-drug Conjugate SHR-A1912' SubClassOf 'Antineoplastic Antibody-Drug Conjugate'</newAxiom>
<newAxiom>'Antibody-drug Conjugate SHR-A1912' SubClassOf 'Immunoconjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185416</classIRI>
<classLabel>Obscurin</classLabel>
<newAxiom>'Obscurin' EquivalentTo 'Serine/Threonine Protein Kinase' and 'Guanine Nucleotide Exchange Factor' and ('Gene_Product_Has_Associated_Anatomy' some 'Sarcolemma') and ('Gene_Product_Has_Associated_Anatomy' some 'Sarcoplasmic Reticulum') and ('Gene_Product_Expressed_In_Tissue' some 'Skeletal Muscle Tissue') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'SH3 Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Immunoglobulin Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Myogenesis') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'G Protein-Coupled Receptor Signaling') and ('Gene_Product_Encoded_By_Gene' some 'OBSCN Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185415</classIRI>
<classLabel>OBSCN wt Allele</classLabel>
<newAxiom>'OBSCN wt Allele' SubClassOf 'OBSCN Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185418</classIRI>
<classLabel>Anti-CCR8 Monoclonal Antibody S-531011</classLabel>
<newAxiom>'Anti-CCR8 Monoclonal Antibody S-531011' SubClassOf 'Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185417</classIRI>
<classLabel>PRMT5 Inhibitor AMG 193</classLabel>
<newAxiom>'PRMT5 Inhibitor AMG 193' SubClassOf 'PRMT5 Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185419</classIRI>
<classLabel>HIF2-alpha Inhibitor NKT2152</classLabel>
<newAxiom>'HIF2-alpha Inhibitor NKT2152' SubClassOf 'Antineoplastic Protein Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185520</classIRI>
<classLabel>Hemoglobin Alpha cis-Deletion with Constant Spring Genotype</classLabel>
<newAxiom>'Hemoglobin Alpha cis-Deletion with Constant Spring Genotype' SubClassOf 'Hemoglobin Alpha Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185522</classIRI>
<classLabel>Hemoglobin Alpha Homozygous Null Genotype</classLabel>
<newAxiom>'Hemoglobin Alpha Homozygous Null Genotype' SubClassOf 'Hemoglobin Alpha Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185521</classIRI>
<classLabel>Equivocal Complete Resection</classLabel>
<newAxiom>'Equivocal Complete Resection' SubClassOf 'Extent of Resection'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185524</classIRI>
<classLabel>Hemoglobin Beta Normal Genotype</classLabel>
<newAxiom>'Hemoglobin Beta Normal Genotype' SubClassOf 'Hemoglobin Beta Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185523</classIRI>
<classLabel>Hemoglobin Beta Genotype Finding</classLabel>
<newAxiom>'Hemoglobin Beta Genotype Finding' SubClassOf 'Hemoglobin Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185526</classIRI>
<classLabel>Procedure Purpose</classLabel>
<newAxiom>'Procedure Purpose' SubClassOf 'Purpose'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185525</classIRI>
<classLabel>Hemoglobin Beta Homozygous Insufficient Genotype</classLabel>
<newAxiom>'Hemoglobin Beta Homozygous Insufficient Genotype' SubClassOf 'Hemoglobin Beta Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185528</classIRI>
<classLabel>Second Look Surgery to Attempt Total Resection</classLabel>
<newAxiom>'Second Look Surgery to Attempt Total Resection' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185527</classIRI>
<classLabel>Initial Diagnostic Procedure</classLabel>
<newAxiom>'Initial Diagnostic Procedure' SubClassOf 'Diagnostic Procedure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185529</classIRI>
<classLabel>Hemoglobin Beta Heterozygous Insufficiency Plus Null Genotype</classLabel>
<newAxiom>'Hemoglobin Beta Heterozygous Insufficiency Plus Null Genotype' SubClassOf 'Hemoglobin Beta Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185511</classIRI>
<classLabel>How Much is Thinking a Problem</classLabel>
<newAxiom>'How Much is Thinking a Problem' SubClassOf 'Thinking Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185510</classIRI>
<classLabel>How Much is Nutrition a Problem</classLabel>
<newAxiom>'How Much is Nutrition a Problem' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185513</classIRI>
<classLabel>Hemoglobin Alpha trans-Deletion Genotype</classLabel>
<newAxiom>'Hemoglobin Alpha trans-Deletion Genotype' SubClassOf 'Hemoglobin Alpha Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185512</classIRI>
<classLabel>Hemoglobin Alpha cis-Deletion Genotype</classLabel>
<newAxiom>'Hemoglobin Alpha cis-Deletion Genotype' SubClassOf 'Hemoglobin Alpha Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185515</classIRI>
<classLabel>How Much are Other Complaints a Problem</classLabel>
<newAxiom>'How Much are Other Complaints a Problem' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185514</classIRI>
<classLabel>How Much is Communication a Problem</classLabel>
<newAxiom>'How Much is Communication a Problem' SubClassOf 'Communication with Doctor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185517</classIRI>
<classLabel>Hemoglobin Alpha Three Copies Deleted Genotype</classLabel>
<newAxiom>'Hemoglobin Alpha Three Copies Deleted Genotype' SubClassOf 'Hemoglobin Alpha Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185516</classIRI>
<classLabel>Single or Multiple Lymph Node Involvement</classLabel>
<newAxiom>'Single or Multiple Lymph Node Involvement' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185519</classIRI>
<classLabel>Multiple Lymph Nodes</classLabel>
<newAxiom>'Multiple Lymph Nodes' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185518</classIRI>
<classLabel>Single Lymph Node</classLabel>
<newAxiom>'Single Lymph Node' SubClassOf 'Clinical or Research Assessment Answer'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185509</classIRI>
<classLabel>How Much is Worry a Problem</classLabel>
<newAxiom>'How Much is Worry a Problem' SubClassOf 'Worry Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185500</classIRI>
<classLabel>Hemoglobin Genotype Finding</classLabel>
<newAxiom>'Hemoglobin Genotype Finding' SubClassOf 'Genetic Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185502</classIRI>
<classLabel>Hemoglobin Alpha with Heterozygous Triplication</classLabel>
<newAxiom>'Hemoglobin Alpha with Heterozygous Triplication' SubClassOf 'Hemoglobin Alpha Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185501</classIRI>
<classLabel>Hemoglobin Alpha Genotype Finding</classLabel>
<newAxiom>'Hemoglobin Alpha Genotype Finding' SubClassOf 'Hemoglobin Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185504</classIRI>
<classLabel>Hemoglobin Alpha One Copy Deleted Genotype</classLabel>
<newAxiom>'Hemoglobin Alpha One Copy Deleted Genotype' SubClassOf 'Hemoglobin Alpha Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185503</classIRI>
<classLabel>Hemoglobin Alpha Normal Genotype</classLabel>
<newAxiom>'Hemoglobin Alpha Normal Genotype' SubClassOf 'Hemoglobin Alpha Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185506</classIRI>
<classLabel>How Much is Pain and Hurt a Problem</classLabel>
<newAxiom>'How Much is Pain and Hurt a Problem' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185505</classIRI>
<classLabel>Pediatric Quality of Life Stem Cell Transplant Module</classLabel>
<newAxiom>'Pediatric Quality of Life Stem Cell Transplant Module' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185508</classIRI>
<classLabel>How Much is Nausea a Problem</classLabel>
<newAxiom>'How Much is Nausea a Problem' SubClassOf 'Nausea Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185507</classIRI>
<classLabel>How Much is Fatigue and Sleep a Problem</classLabel>
<newAxiom>'How Much is Fatigue and Sleep a Problem' SubClassOf 'Sleep Question'</newAxiom>
<newAxiom>'How Much is Fatigue and Sleep a Problem' SubClassOf 'Fatigue Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185593</classIRI>
<classLabel>BTK Inhibitor HMPL-760</classLabel>
<newAxiom>'BTK Inhibitor HMPL-760' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
<newAxiom>'BTK Inhibitor HMPL-760' SubClassOf 'BTK Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185592</classIRI>
<classLabel>POU Domain, Class 2, Transcription Factor 3</classLabel>
<newAxiom>'POU Domain, Class 2, Transcription Factor 3' EquivalentTo 'Transcription Factor' and ('Gene_Product_Has_Chemical_Classification' some 'Homeobox Family Protein') and ('Gene_Product_Has_Associated_Anatomy' some 'Keratinocyte') and ('Gene_Product_Has_Associated_Anatomy' some 'Nucleus') and ('Gene_Product_Expressed_In_Tissue' some 'Epidermis') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Homeo Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'POU Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Sequence-Specific DNA Binding Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Transcriptional Activation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'DNA Binding') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Keratinocyte Differentiation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Stimulation of Cell Proliferation') and ('Gene_Product_Encoded_By_Gene' some 'POU2F3 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185595</classIRI>
<classLabel>CCR8 Inhibitor IPG7236</classLabel>
<newAxiom>'CCR8 Inhibitor IPG7236' SubClassOf 'Antineoplastic Immunomodulating Agent'</newAxiom>
<newAxiom>'CCR8 Inhibitor IPG7236' SubClassOf 'Adenovirus Vaccine'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185594</classIRI>
<classLabel>Allogeneic NK-like Cells GAIA-102</classLabel>
<newAxiom>'Allogeneic NK-like Cells GAIA-102' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
<newAxiom>'Allogeneic NK-like Cells GAIA-102' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185597</classIRI>
<classLabel>cPLA2 Inhibiting Silicone-based Gel AVX001</classLabel>
<newAxiom>'cPLA2 Inhibiting Silicone-based Gel AVX001' SubClassOf 'Topical Preparation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185596</classIRI>
<classLabel>Pan-variant KIT Inhibitor THE-630</classLabel>
<newAxiom>'Pan-variant KIT Inhibitor THE-630' SubClassOf 'c-KIT Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185599</classIRI>
<classLabel>SHP2 Inhibitor HBI-2376</classLabel>
<newAxiom>'SHP2 Inhibitor HBI-2376' SubClassOf 'SHP2 Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185598</classIRI>
<classLabel>Autologous Anti-mesothelin CAR-IL-7-CCL19-expressing T-lymphocytes TAK-103</classLabel>
<newAxiom>'Autologous Anti-mesothelin CAR-IL-7-CCL19-expressing T-lymphocytes TAK-103' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
<newAxiom>'Autologous Anti-mesothelin CAR-IL-7-CCL19-expressing T-lymphocytes TAK-103' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Autologous Anti-mesothelin CAR-IL-7-CCL19-expressing T-lymphocytes TAK-103' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185591</classIRI>
<classLabel>POU2F3 wt Allele</classLabel>
<newAxiom>'POU2F3 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '11q23.3'</newAxiom>
<newAxiom>'POU2F3 wt Allele' SubClassOf 'POU2F3 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185590</classIRI>
<classLabel>Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells</classLabel>
<newAxiom>'Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
<newAxiom>'Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185582</classIRI>
<classLabel>Hemoglobin Beta Heterozygous Null Genotype</classLabel>
<newAxiom>'Hemoglobin Beta Heterozygous Null Genotype' SubClassOf 'Hemoglobin Beta Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185581</classIRI>
<classLabel>Hemoglobin Beta Heterozygous Insufficiency Genotype</classLabel>
<newAxiom>'Hemoglobin Beta Heterozygous Insufficiency Genotype' SubClassOf 'Hemoglobin Beta Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185584</classIRI>
<classLabel>CIDEB wt Allele</classLabel>
<newAxiom>'CIDEB wt Allele' SubClassOf 'CIDEB Gene'</newAxiom>
<newAxiom>'CIDEB wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '14q12'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185583</classIRI>
<classLabel>CIDEB Gene</classLabel>
<newAxiom>'CIDEB Gene' SubClassOf 'Apoptosis Promoter Gene'</newAxiom>
<newAxiom>'CIDEB Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Positive Regulation of Apoptosis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185586</classIRI>
<classLabel>GPAM Gene</classLabel>
<newAxiom>'GPAM Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Phospholipid Metabolism'</newAxiom>
<newAxiom>'GPAM Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Triglyceride Metabolism'</newAxiom>
<newAxiom>'GPAM Gene' SubClassOf 'Transferase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185585</classIRI>
<classLabel>Cell Death Activator CIDE-B</classLabel>
<newAxiom>'Cell Death Activator CIDE-B' SubClassOf 'Apoptosis Regulator'</newAxiom>
<newAxiom>'Cell Death Activator CIDE-B' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'CIDEB Gene'</newAxiom>
<newAxiom>'Cell Death Activator CIDE-B' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Cytosol'</newAxiom>
<newAxiom>'Cell Death Activator CIDE-B' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Positive Regulation of Apoptosis'</newAxiom>
<newAxiom>'Cell Death Activator CIDE-B' SubClassOf 'Gene_Product_Has_Biochemical_Function' some 'Apoptosis Promoter'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185588</classIRI>
<classLabel>Glycerol-3-Phosphate Acyltransferase 1, Mitochondrial</classLabel>
<newAxiom>'Glycerol-3-Phosphate Acyltransferase 1, Mitochondrial' EquivalentTo 'Acyltransferase' and ('Gene_Product_Is_Element_In_Pathway' some 'Glycerolipid Metabolism Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Glycerophospholipid Metabolism Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Outer Mitochondrial Membrane') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Transmembrane Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Phospholipid Metabolism') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Triglyceride Metabolism') and ('Gene_Product_Encoded_By_Gene' some 'GPAM Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185587</classIRI>
<classLabel>GPAM wt Allele</classLabel>
<newAxiom>'GPAM wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Glycerolipid Metabolism Pathway'</newAxiom>
<newAxiom>'GPAM wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Glycerophospholipid Metabolism Pathway'</newAxiom>
<newAxiom>'GPAM wt Allele' SubClassOf 'GPAM Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185589</classIRI>
<classLabel>POU2F3 Gene</classLabel>
<newAxiom>'POU2F3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'DNA Binding'</newAxiom>
<newAxiom>'POU2F3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Stimulation of Cell Proliferation'</newAxiom>
<newAxiom>'POU2F3 Gene' SubClassOf 'Homeobox Gene'</newAxiom>
<newAxiom>'POU2F3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Transcriptional Activation'</newAxiom>
<newAxiom>'POU2F3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Keratinocyte Differentiation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185580</classIRI>
<classLabel>Ras GTPase-Activating Protein nGAP</classLabel>
<newAxiom>'Ras GTPase-Activating Protein nGAP' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Cytosol'</newAxiom>
<newAxiom>'Ras GTPase-Activating Protein nGAP' SubClassOf 'Gene_Product_Has_Structural_Domain_Or_Motif' some 'PH Domain'</newAxiom>
<newAxiom>'Ras GTPase-Activating Protein nGAP' SubClassOf 'GTPase-Activating Protein'</newAxiom>
<newAxiom>'Ras GTPase-Activating Protein nGAP' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'RASAL2 Gene'</newAxiom>
<newAxiom>'Ras GTPase-Activating Protein nGAP' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction Inhibition'</newAxiom>
<newAxiom>'Ras GTPase-Activating Protein nGAP' SubClassOf 'Gene_Product_Has_Structural_Domain_Or_Motif' some 'C2 Domain'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185571</classIRI>
<classLabel>RALGAPA2 Gene</classLabel>
<newAxiom>'RALGAPA2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'RALGAPA2 Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185570</classIRI>
<classLabel>Ral GTPase-Activating Protein Subunit Alpha-1</classLabel>
<newAxiom>'Ral GTPase-Activating Protein Subunit Alpha-1' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'RALGAPA1 Gene'</newAxiom>
<newAxiom>'Ral GTPase-Activating Protein Subunit Alpha-1' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm'</newAxiom>
<newAxiom>'Ral GTPase-Activating Protein Subunit Alpha-1' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'Ral GTPase-Activating Protein Subunit Alpha-1' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Nucleus'</newAxiom>
<newAxiom>'Ral GTPase-Activating Protein Subunit Alpha-1' SubClassOf 'GTPase-Activating Protein'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185573</classIRI>
<classLabel>Ral GTPase-Activating Protein Subunit Alpha-2</classLabel>
<newAxiom>'Ral GTPase-Activating Protein Subunit Alpha-2' SubClassOf 'Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm'</newAxiom>
<newAxiom>'Ral GTPase-Activating Protein Subunit Alpha-2' SubClassOf 'Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'Ral GTPase-Activating Protein Subunit Alpha-2' SubClassOf 'Gene_Product_Encoded_By_Gene' some 'RALGAPA2 Gene'</newAxiom>
<newAxiom>'Ral GTPase-Activating Protein Subunit Alpha-2' SubClassOf 'GTPase-Activating Protein'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185572</classIRI>
<classLabel>RALGAPA2 wt Allele</classLabel>
<newAxiom>'RALGAPA2 wt Allele' SubClassOf 'RALGAPA2 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185575</classIRI>
<classLabel>Diacylglycerol Kinase Zeta Inhibitor ASP1570</classLabel>
<newAxiom>'Diacylglycerol Kinase Zeta Inhibitor ASP1570' SubClassOf 'Antineoplastic Enzyme Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185574</classIRI>
<classLabel>RAPGEF2 Gene</classLabel>
<newAxiom>'RAPGEF2 Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
<newAxiom>'RAPGEF2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Neural Development'</newAxiom>
<newAxiom>'RAPGEF2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Angiogenic Process'</newAxiom>
<newAxiom>'RAPGEF2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185577</classIRI>
<classLabel>Rap Guanine Nucleotide Exchange Factor 2</classLabel>
<newAxiom>'Rap Guanine Nucleotide Exchange Factor 2' EquivalentTo 'Guanine Nucleotide Exchange Factor' and ('Gene_Product_Is_Element_In_Pathway' some 'MAPK Signaling Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Tight Junction Assembly Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Neuron') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Has_Associated_Anatomy' some 'Tight Junction') and ('Gene_Product_Has_Associated_Anatomy' some 'Plasma Membrane') and ('Gene_Product_Has_Associated_Anatomy' some 'Endocrine Cell') and ('Gene_Product_Has_Associated_Anatomy' some 'Late Endosome') and ('Gene_Product_Expressed_In_Tissue' some 'Brain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'PDZ Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Angiogenic Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Neural Development') and ('Gene_Product_Encoded_By_Gene' some 'RAPGEF2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185576</classIRI>
<classLabel>RAPGEF2 wt Allele</classLabel>
<newAxiom>'RAPGEF2 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Tight Junction Assembly Pathway'</newAxiom>
<newAxiom>'RAPGEF2 wt Allele' SubClassOf 'RAPGEF2 Gene'</newAxiom>
<newAxiom>'RAPGEF2 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'MAPK Signaling Pathway'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185579</classIRI>
<classLabel>RASAL2 wt Allele</classLabel>
<newAxiom>'RASAL2 wt Allele' SubClassOf 'RASAL2 Gene'</newAxiom>
<newAxiom>'RASAL2 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '1q25.2'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185578</classIRI>
<classLabel>RASAL2 Gene</classLabel>
<newAxiom>'RASAL2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction Inhibition'</newAxiom>
<newAxiom>'RASAL2 Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185560</classIRI>
<classLabel>CD73 Inhibitor ORIC-533</classLabel>
<newAxiom>'CD73 Inhibitor ORIC-533' SubClassOf 'Antineoplastic Immunomodulating Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185562</classIRI>
<classLabel>EPHA6 wt Allele</classLabel>
<newAxiom>'EPHA6 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Ephrin A Forward Signaling Pathway'</newAxiom>
<newAxiom>'EPHA6 wt Allele' SubClassOf 'EPHA6 Gene'</newAxiom>
<newAxiom>'EPHA6 wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'Axon Guidance Pathway'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185561</classIRI>
<classLabel>EPHA6 Gene</classLabel>
<newAxiom>'EPHA6 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Tyrosine Phosphorylation'</newAxiom>
<newAxiom>'EPHA6 Gene' SubClassOf 'Receptor Tyrosine Kinase Gene'</newAxiom>
<newAxiom>'EPHA6 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Receptor Signaling'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185564</classIRI>
<classLabel>TIAM2 Gene</classLabel>
<newAxiom>'TIAM2 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'TIAM2 Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185563</classIRI>
<classLabel>Ephrin Type-A Receptor 6</classLabel>
<newAxiom>'Ephrin Type-A Receptor 6' EquivalentTo 'Receptor Tyrosine Kinase' and ('Gene_Product_Is_Element_In_Pathway' some 'Axon Guidance Pathway') and ('Gene_Product_Is_Element_In_Pathway' some 'Ephrin A Forward Signaling Pathway') and ('Gene_Product_Has_Biochemical_Function' some 'EphA Receptor Family') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Tyrosine Phosphorylation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Receptor Signaling') and ('Gene_Product_Encoded_By_Gene' some 'EPHA6 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185566</classIRI>
<classLabel>TIAM2 wt Allele</classLabel>
<newAxiom>'TIAM2 wt Allele' SubClassOf 'TIAM2 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185565</classIRI>
<classLabel>Antibody-drug Conjugate TORL-2-307-ADC</classLabel>
<newAxiom>'Antibody-drug Conjugate TORL-2-307-ADC' SubClassOf 'Immunoconjugate'</newAxiom>
<newAxiom>'Antibody-drug Conjugate TORL-2-307-ADC' SubClassOf 'Antineoplastic Antibody-Drug Conjugate'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185568</classIRI>
<classLabel>RALGAPA1 Gene</classLabel>
<newAxiom>'RALGAPA1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'RALGAPA1 Gene' SubClassOf 'Signaling Pathway Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185567</classIRI>
<classLabel>Rho Guanine Nucleotide Exchange Factor TIAM2</classLabel>
<newAxiom>'Rho Guanine Nucleotide Exchange Factor TIAM2' EquivalentTo 'Guanine Nucleotide Exchange Factor' and ('Gene_Product_Expressed_In_Tissue' some 'Testis') and ('Gene_Product_Expressed_In_Tissue' some 'Brain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'PDZ Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'DH Domain') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'PH Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Encoded_By_Gene' some 'TIAM2 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185569</classIRI>
<classLabel>RALGAPA1 wt Allele</classLabel>
<newAxiom>'RALGAPA1 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '14q13.2'</newAxiom>
<newAxiom>'RALGAPA1 wt Allele' SubClassOf 'RALGAPA1 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185551</classIRI>
<classLabel>ALPK3 Gene</classLabel>
<newAxiom>'ALPK3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Serine/Threonine Phosphorylation'</newAxiom>
<newAxiom>'ALPK3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Myogenesis'</newAxiom>
<newAxiom>'ALPK3 Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
<newAxiom>'ALPK3 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cell Differentiation Process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185550</classIRI>
<classLabel>Microtubule-Associated Serine/Threonine-Protein Kinase 4</classLabel>
<newAxiom>'Microtubule-Associated Serine/Threonine-Protein Kinase 4' EquivalentTo 'Serine/Threonine Protein Kinase' and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'PDZ Domain') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Serine/Threonine Phosphorylation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Microtubule Process') and ('Gene_Product_Encoded_By_Gene' some 'MAST4 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185553</classIRI>
<classLabel>Alpha-Protein Kinase 3</classLabel>
<newAxiom>'Alpha-Protein Kinase 3' EquivalentTo 'Serine/Threonine Protein Kinase' and ('Gene_Product_Has_Associated_Anatomy' some 'Cardiomyocyte') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Immunoglobulin Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Signaling Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cell Differentiation Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Myogenesis') and ('Gene_Product_Encoded_By_Gene' some 'ALPK3 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185552</classIRI>
<classLabel>ALPK3 wt Allele</classLabel>
<newAxiom>'ALPK3 wt Allele' SubClassOf 'ALPK3 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185555</classIRI>
<classLabel>LRRK1 wt Allele</classLabel>
<newAxiom>'LRRK1 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '15q26.3'</newAxiom>
<newAxiom>'LRRK1 wt Allele' SubClassOf 'LRRK1 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185554</classIRI>
<classLabel>LRRK1 Gene</classLabel>
<newAxiom>'LRRK1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Bone Remodeling'</newAxiom>
<newAxiom>'LRRK1 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Serine/Threonine Phosphorylation'</newAxiom>
<newAxiom>'LRRK1 Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185557</classIRI>
<classLabel>TNIK Gene</classLabel>
<newAxiom>'TNIK Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
<newAxiom>'TNIK Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction Induction'</newAxiom>
<newAxiom>'TNIK Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Serine/Threonine Phosphorylation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185556</classIRI>
<classLabel>Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1</classLabel>
<newAxiom>'Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1' EquivalentTo 'Serine/Threonine Protein Kinase' and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Ankyrin Repeat') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Leucine-Rich Repeat') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Serine/Threonine Phosphorylation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Bone Remodeling') and ('Gene_Product_Encoded_By_Gene' some 'LRRK1 Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185559</classIRI>
<classLabel>TRAF2 and NCK-Interacting Protein Kinase</classLabel>
<newAxiom>'TRAF2 and NCK-Interacting Protein Kinase' EquivalentTo 'Serine/Threonine Protein Kinase' and ('Gene_Product_Is_Element_In_Pathway' some 'TNF Receptor Family Signaling Pathway') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoplasm') and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoskeleton') and ('Gene_Product_Has_Associated_Anatomy' some 'Endosome') and ('Gene_Product_Expressed_In_Tissue' some 'Skeletal Muscle Tissue') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Serine/Threonine Phosphorylation') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction Induction') and ('Gene_Product_Encoded_By_Gene' some 'TNIK Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185558</classIRI>
<classLabel>TNIK wt Allele</classLabel>
<newAxiom>'TNIK wt Allele' SubClassOf 'TNIK Gene'</newAxiom>
<newAxiom>'TNIK wt Allele' SubClassOf 'Gene_Is_Element_In_Pathway' some 'TNF Receptor Family Signaling Pathway'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185540</classIRI>
<classLabel>HBA2 NM_000517.6:c.427TC</classLabel>
<newAxiom>'HBA2 NM_000517.6:c.427TC' SubClassOf 'HBA2 Gene Mutation'</newAxiom>
<newAxiom>'HBA2 NM_000517.6:c.427TC' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'HBA2 NP_000508.1:p.*143Qext*31'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185542</classIRI>
<classLabel>SPEG Gene</classLabel>
<newAxiom>'SPEG Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Myogenesis'</newAxiom>
<newAxiom>'SPEG Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Serine/Threonine Phosphorylation'</newAxiom>
<newAxiom>'SPEG Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Cell Differentiation Process'</newAxiom>
<newAxiom>'SPEG Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185541</classIRI>
<classLabel>HBA2 NP_000508.1:p.*143Qext*31</classLabel>
<newAxiom>'HBA2 NP_000508.1:p.*143Qext*31' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'HBA2 NM_000517.6:c.427TC'</newAxiom>
<newAxiom>'HBA2 NP_000508.1:p.*143Qext*31' SubClassOf 'HBA Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185544</classIRI>
<classLabel>Striated Muscle Preferentially Expressed Protein Kinase</classLabel>
<newAxiom>'Striated Muscle Preferentially Expressed Protein Kinase' EquivalentTo 'Serine/Threonine Protein Kinase' and ('Gene_Product_Has_Associated_Anatomy' some 'Striated Muscle Cell') and ('Gene_Product_Has_Structural_Domain_Or_Motif' some 'Immunoglobulin Domain') and ('Gene_Product_Has_Biochemical_Function' some 'Signaling Protein') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Cell Differentiation Process') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Signal Transduction') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Myogenesis') and ('Gene_Product_Encoded_By_Gene' some 'SPEG Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185543</classIRI>
<classLabel>SPEG wt Allele</classLabel>
<newAxiom>'SPEG wt Allele' SubClassOf 'SPEG Gene'</newAxiom>
<newAxiom>'SPEG wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '2q35'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185546</classIRI>
<classLabel>MYO3A wt Allele</classLabel>
<newAxiom>'MYO3A wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '10p12.1'</newAxiom>
<newAxiom>'MYO3A wt Allele' SubClassOf 'MYO3A Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185545</classIRI>
<classLabel>MYO3A Gene</classLabel>
<newAxiom>'MYO3A Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
<newAxiom>'MYO3A Gene' SubClassOf 'Cytoskeletal Gene'</newAxiom>
<newAxiom>'MYO3A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Hearing'</newAxiom>
<newAxiom>'MYO3A Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Visual Perception'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185548</classIRI>
<classLabel>MAST4 Gene</classLabel>
<newAxiom>'MAST4 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Serine/Threonine Phosphorylation'</newAxiom>
<newAxiom>'MAST4 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Signal Transduction'</newAxiom>
<newAxiom>'MAST4 Gene' SubClassOf 'Gene_Plays_Role_In_Process' some 'Microtubule Process'</newAxiom>
<newAxiom>'MAST4 Gene' SubClassOf 'Serine/Threonine Protein Kinase Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185547</classIRI>
<classLabel>Myosin-IIIa</classLabel>
<newAxiom>'Myosin-IIIa' EquivalentTo 'Cytoskeletal Protein' and 'Serine/Threonine Protein Kinase' and ('Gene_Product_Has_Associated_Anatomy' some 'Cytoskeleton') and ('Gene_Product_Has_Associated_Anatomy' some 'Stereocilium') and ('Gene_Product_Expressed_In_Tissue' some 'Pancreas') and ('Gene_Product_Expressed_In_Tissue' some 'Cochlea') and ('Gene_Product_Expressed_In_Tissue' some 'Retinal Pigment Epithelium') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Hearing') and ('Gene_Product_Plays_Role_In_Biological_Process' some 'Visual Perception') and ('Gene_Product_Encoded_By_Gene' some 'MYO3A Gene')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185549</classIRI>
<classLabel>MAST4 wt Allele</classLabel>
<newAxiom>'MAST4 wt Allele' SubClassOf 'Gene_In_Chromosomal_Location' some '5q12.3'</newAxiom>
<newAxiom>'MAST4 wt Allele' SubClassOf 'MAST4 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185531</classIRI>
<classLabel>Hemoglobin Beta Heterozygous Hemoglobin E Plus Insufficiency Genotype</classLabel>
<newAxiom>'Hemoglobin Beta Heterozygous Hemoglobin E Plus Insufficiency Genotype' SubClassOf 'Hemoglobin Beta Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185530</classIRI>
<classLabel>Biopsy of Distant Site for Staging</classLabel>
<newAxiom>'Biopsy of Distant Site for Staging' SubClassOf 'Reason for Biopsy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185533</classIRI>
<classLabel>Hemoglobin Beta Homozygous Null Genotype</classLabel>
<newAxiom>'Hemoglobin Beta Homozygous Null Genotype' SubClassOf 'Hemoglobin Beta Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185532</classIRI>
<classLabel>Hemoglobin Beta Heterozygous Hemoglobin E Plus Null Genotype</classLabel>
<newAxiom>'Hemoglobin Beta Heterozygous Hemoglobin E Plus Null Genotype' SubClassOf 'Hemoglobin Beta Genotype Finding'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185535</classIRI>
<classLabel>Immunohistochemistry Specimen Type</classLabel>
<newAxiom>'Immunohistochemistry Specimen Type' SubClassOf 'Laboratory Specimen Type'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185534</classIRI>
<classLabel>Diagnostic Biopsy for Possible Recurrence</classLabel>
<newAxiom>'Diagnostic Biopsy for Possible Recurrence' SubClassOf 'Reason for Biopsy'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185537</classIRI>
<classLabel>HBB NP_000509.1:p.E27K</classLabel>
<newAxiom>'HBB NP_000509.1:p.E27K' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'HBB NM_000518.5:c.79GA'</newAxiom>
<newAxiom>'HBB NP_000509.1:p.E27K' SubClassOf 'HBB Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185536</classIRI>
<classLabel>HBB NM_000518.5:c.79GA</classLabel>
<newAxiom>'HBB NM_000518.5:c.79GA' SubClassOf 'HBB Gene Mutation'</newAxiom>
<newAxiom>'HBB NM_000518.5:c.79GA' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'HBB NP_000509.1:p.E27K'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185539</classIRI>
<classLabel>HBA Protein Variant</classLabel>
<newAxiom>'HBA Protein Variant' SubClassOf 'Gene Product Sequence Variation'</newAxiom>
<newAxiom>'HBA Protein Variant' SubClassOf 'Gene_Product_Variant_Of_Gene_Product' some 'Hemoglobin Subunit Alpha'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185538</classIRI>
<classLabel>HBA2 Gene Mutation</classLabel>
<newAxiom>'HBA2 Gene Mutation' SubClassOf 'Gene Variant'</newAxiom>
<newAxiom>'HBA2 Gene Mutation' SubClassOf 'Molecular_Abnormality_Involves_Gene' some 'HBA2 Gene'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185395</classIRI>
<classLabel>Anti-TIGIT Monoclonal Antibody BAT6021</classLabel>
<newAxiom>'Anti-TIGIT Monoclonal Antibody BAT6021' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-TIGIT Monoclonal Antibody BAT6021' SubClassOf 'Anti-TIGIT Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185394</classIRI>
<classLabel>Anti-CD73 Monoclonal Antibody IBI325</classLabel>
<newAxiom>'Anti-CD73 Monoclonal Antibody IBI325' SubClassOf 'Anti-CD73 Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185397</classIRI>
<classLabel>Anti-HPV16 TCR-engineered T-cells CRTE7A2-01</classLabel>
<newAxiom>'Anti-HPV16 TCR-engineered T-cells CRTE7A2-01' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Anti-HPV16 TCR-engineered T-cells CRTE7A2-01' SubClassOf 'T-cell Receptor-engineered T-cells'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185396</classIRI>
<classLabel>BET Inhibitor TQB3617</classLabel>
<newAxiom>'BET Inhibitor TQB3617' SubClassOf 'BET Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185399</classIRI>
<classLabel>CD137/Nectin-4 Bispecific-targeting Agent BT7480</classLabel>
<newAxiom>'CD137/Nectin-4 Bispecific-targeting Agent BT7480' SubClassOf 'Antineoplastic Immunomodulating Agent'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185398</classIRI>
<classLabel>KRAS G12C Inhibitor YL-15293</classLabel>
<newAxiom>'KRAS G12C Inhibitor YL-15293' SubClassOf 'Ras Inhibitor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185391</classIRI>
<classLabel>Anti-TIGIT Monoclonal Antibody BAT6005</classLabel>
<newAxiom>'Anti-TIGIT Monoclonal Antibody BAT6005' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-TIGIT Monoclonal Antibody BAT6005' SubClassOf 'Anti-TIGIT Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185390</classIRI>
<classLabel>Anti-PD-1 Monoclonal Antibody BAT1308</classLabel>
<newAxiom>'Anti-PD-1 Monoclonal Antibody BAT1308' SubClassOf 'Antineoplastic Antibody'</newAxiom>
<newAxiom>'Anti-PD-1 Monoclonal Antibody BAT1308' SubClassOf 'Anti-PD1 Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185393</classIRI>
<classLabel>Oncolytic Virus RT-01</classLabel>
<newAxiom>'Oncolytic Virus RT-01' SubClassOf 'Oncolytic Virus'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185392</classIRI>
<classLabel>Autologous Anti-GPC3 CAR T Cells BOXR1030</classLabel>
<newAxiom>'Autologous Anti-GPC3 CAR T Cells BOXR1030' SubClassOf 'Chimeric Antigen Receptor T-cells'</newAxiom>
<newAxiom>'Autologous Anti-GPC3 CAR T Cells BOXR1030' SubClassOf 'Antineoplastic Immune Cell'</newAxiom>
<newAxiom>'Autologous Anti-GPC3 CAR T Cells BOXR1030' SubClassOf 'Therapeutic Autologous Lymphocytes'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185384</classIRI>
<classLabel>Pain Felt Tingly</classLabel>
<newAxiom>'Pain Felt Tingly' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185383</classIRI>
<classLabel>Pain Felt Like Pins and Needles</classLabel>
<newAxiom>'Pain Felt Like Pins and Needles' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185386</classIRI>
<classLabel>Pain Felt Electrical</classLabel>
<newAxiom>'Pain Felt Electrical' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185385</classIRI>
<classLabel>Pain Felt Stinging</classLabel>
<newAxiom>'Pain Felt Stinging' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185388</classIRI>
<classLabel>Neuropathic Pain Quality Scale</classLabel>
<newAxiom>'Neuropathic Pain Quality Scale' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185387</classIRI>
<classLabel>Pain Felt Numb</classLabel>
<newAxiom>'Pain Felt Numb' SubClassOf 'Pain Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185389</classIRI>
<classLabel>Anti-OX40 Agonist Monoclonal Antibody BAT6026</classLabel>
<newAxiom>'Anti-OX40 Agonist Monoclonal Antibody BAT6026' SubClassOf 'Chemical_Or_Drug_Has_Mechanism_Of_Action' some 'Antigen Binding'</newAxiom>
<newAxiom>'Anti-OX40 Agonist Monoclonal Antibody BAT6026' SubClassOf 'Anti-OX40 Monoclonal Antibody'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185380</classIRI>
<classLabel>H3.3 K27I Variant</classLabel>
<newAxiom>'H3.3 K27I Variant' SubClassOf 'Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant' some 'H3-3A NM_002107.4:c.83_84delinsTT'</newAxiom>
<newAxiom>'H3.3 K27I Variant' SubClassOf 'H3 K27I Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185382</classIRI>
<classLabel>PD-L1 Expression Less than 1 Percent</classLabel>
<newAxiom>'PD-L1 Expression Less than 1 Percent' SubClassOf 'Immunohistochemical Status of PD-L1'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185381</classIRI>
<classLabel>Metastatic Mesonephric Adenocarcinoma</classLabel>
<newAxiom>'Metastatic Mesonephric Adenocarcinoma' EquivalentTo 'Metastatic Genitourinary System Carcinoma' and 'Metastatic Malignant Female Reproductive System Neoplasm' and 'Mesonephric Adenocarcinoma' and 'Metastatic Adenocarcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185373</classIRI>
<classLabel>Clinical Frailty Scale</classLabel>
<newAxiom>'Clinical Frailty Scale' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185372</classIRI>
<classLabel>Myelodysplastic Syndrome-Specific Comorbidity Index</classLabel>
<newAxiom>'Myelodysplastic Syndrome-Specific Comorbidity Index' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185375</classIRI>
<classLabel>H3 K27X Variant</classLabel>
<newAxiom>'H3 K27X Variant' SubClassOf 'H3 Protein Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185374</classIRI>
<classLabel>Adherence to Refills and Medications Scale</classLabel>
<newAxiom>'Adherence to Refills and Medications Scale' SubClassOf 'Research or Clinical Assessment Tool'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185376</classIRI>
<classLabel>EZHIP Overexpression Positive</classLabel>
<newAxiom>'EZHIP Overexpression Positive' SubClassOf 'Elevated Expression'</newAxiom>
<newAxiom>'EZHIP Overexpression Positive' SubClassOf 'Positive Laboratory Test Result'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185379</classIRI>
<classLabel>H3 K27I Variant</classLabel>
<newAxiom>'H3 K27I Variant' SubClassOf 'H3 K27X Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185378</classIRI>
<classLabel>H3-3A NM_002107.4:c.83_84delinsTT</classLabel>
<newAxiom>'H3-3A NM_002107.4:c.83_84delinsTT' SubClassOf 'H3-3A Gene Mutation'</newAxiom>
<newAxiom>'H3-3A NM_002107.4:c.83_84delinsTT' SubClassOf 'Gene_Mutant_Encodes_Gene_Product_Sequence_Variation' some 'H3.3 K27I Variant'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185371</classIRI>
<classLabel>Diffuse Hemispheric Glioma, H3 G34-Mutant</classLabel>
<newAxiom>'Diffuse Hemispheric Glioma, H3 G34-Mutant' EquivalentTo 'Diffuse Glioma' and 'Malignant Brain Glioma' and 'Malignant Cerebral Neoplasm' and ('Disease_Has_Primary_Anatomic_Site' some 'Cerebral Hemisphere') and ('Disease_Has_Molecular_Abnormality' some 'H3 G35X Variant') and ('Disease_Is_Grade' some 'Grade 4')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185370</classIRI>
<classLabel>Diffuse Midline Glioma with EZHIP Overexpression</classLabel>
<newAxiom>'Diffuse Midline Glioma with EZHIP Overexpression' EquivalentTo 'Diffuse Midline Glioma, H3 K27-Altered' and ('Disease_Has_Finding' some 'EZHIP Overexpression Positive')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185362</classIRI>
<classLabel>Vaginal Epithelial Integrity</classLabel>
<newAxiom>'Vaginal Epithelial Integrity' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185361</classIRI>
<classLabel>Vaginal Thickness</classLabel>
<newAxiom>'Vaginal Thickness' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185364</classIRI>
<classLabel>Extent of Vulvar Atrophy</classLabel>
<newAxiom>'Extent of Vulvar Atrophy' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185363</classIRI>
<classLabel>Appearance or Condition of Vaginal Vascularity</classLabel>
<newAxiom>'Appearance or Condition of Vaginal Vascularity' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185366</classIRI>
<classLabel>Presence of Vaginal Stenosis</classLabel>
<newAxiom>'Presence of Vaginal Stenosis' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185365</classIRI>
<classLabel>Presence of Vaginal Vestibular Irritation</classLabel>
<newAxiom>'Presence of Vaginal Vestibular Irritation' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185368</classIRI>
<classLabel>Diffuse Midline Glioma, H3 K27-Altered</classLabel>
<newAxiom>'Diffuse Midline Glioma, H3 K27-Altered' EquivalentTo 'Diffuse Midline Glioma' and ('Disease_Has_Molecular_Abnormality' some 'H3 K27X Variant')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185367</classIRI>
<classLabel>Incontinence Pad Use</classLabel>
<newAxiom>'Incontinence Pad Use' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185369</classIRI>
<classLabel>Diffuse Midline Glioma, EGFR-Mutant</classLabel>
<newAxiom>'Diffuse Midline Glioma, EGFR-Mutant' EquivalentTo 'Diffuse Midline Glioma, H3 K27-Altered' and ('Disease_Has_Molecular_Abnormality' some 'EGFR Gene Mutation')</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185360</classIRI>
<classLabel>Length of Vagina</classLabel>
<newAxiom>'Length of Vagina' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185351</classIRI>
<classLabel>Locally Advanced Paranasal Sinus Squamous Cell Carcinoma</classLabel>
<newAxiom>'Locally Advanced Paranasal Sinus Squamous Cell Carcinoma' EquivalentTo 'Locally Advanced Sinonasal Squamous Cell Carcinoma' and 'Metastatic Paranasal Sinus Squamous Cell Carcinoma' and 'Locally Advanced Paranasal Sinus Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185350</classIRI>
<classLabel>Locally Advanced Nasal Cavity Squamous Cell Carcinoma</classLabel>
<newAxiom>'Locally Advanced Nasal Cavity Squamous Cell Carcinoma' EquivalentTo 'Locally Advanced Sinonasal Squamous Cell Carcinoma' and 'Metastatic Nasal Cavity Squamous Cell Carcinoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185353</classIRI>
<classLabel>Gynecological Health Question</classLabel>
<newAxiom>'Gynecological Health Question' SubClassOf 'Clinical or Research Assessment Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185352</classIRI>
<classLabel>Drug-eluting Contact Lens Dosage Form</classLabel>
<newAxiom>'Drug-eluting Contact Lens Dosage Form' SubClassOf 'Solid Dosage Form'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185355</classIRI>
<classLabel>Severity of Vaginal Scarring or Adhesions</classLabel>
<newAxiom>'Severity of Vaginal Scarring or Adhesions' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185354</classIRI>
<classLabel>Severity of Vaginal Agglutination</classLabel>
<newAxiom>'Severity of Vaginal Agglutination' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185357</classIRI>
<classLabel>Vaginal Moisture</classLabel>
<newAxiom>'Vaginal Moisture' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185356</classIRI>
<classLabel>Vaginal pH</classLabel>
<newAxiom>'Vaginal pH' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185359</classIRI>
<classLabel>Vaginal Elasticity</classLabel>
<newAxiom>'Vaginal Elasticity' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185358</classIRI>
<classLabel>Vaginal Rugosity</classLabel>
<newAxiom>'Vaginal Rugosity' SubClassOf 'Gynecological Health Question'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185348</classIRI>
<classLabel>Symmetric Dimethylarginine</classLabel>
<newAxiom>'Symmetric Dimethylarginine' SubClassOf 'Amino Acid Derivative'</newAxiom>
</newClass>
<newClass>
<classIRI>http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C185349</classIRI>
<classLabel>del(11q22.3)</classLabel>
<newAxiom>'del(11q22.3)' SubClassOf 'Rearrangement of 11q'</newAxiom>
<newAxiom>'del(11q22.3)' SubClassOf 'Chromosomal Deletion'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
</deletedClasses>
</diffReport>