<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
41
</numberChangedClasses>
<numberNewClasses>
14
</numberNewClasses>
<numberDeletedClasses>
1
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/OBI_0600002</classIRI>
<classLabel>tumor grading</classLabel>
<deletedAxiom>&apos;tumor grading&apos; SubClassOf &apos;assay&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/HP_0004936</classIRI>
<classLabel>Venous thrombosis</classLabel>
<deletedAxiom>&apos;Venous thrombosis&apos; SubClassOf &apos;abnormality of blood and blood-forming tissues&apos;</deletedAxiom>
<newAxiom>&apos;Venous thrombosis&apos; SubClassOf http://purl.obolibrary.org/obo/HP_0001977</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0000948</classIRI>
<classLabel>joint</classLabel>
<deletedAxiom>&apos;joint&apos; SubClassOf &apos;skeleton structure&apos;</deletedAxiom>
<newAxiom>&apos;joint&apos; SubClassOf &apos;obsolete class&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0000961</classIRI>
<classLabel>adult segment</classLabel>
<deletedAxiom>&apos;adult segment&apos; SubClassOf &apos;animal component&apos;</deletedAxiom>
<newAxiom>&apos;adult segment&apos; SubClassOf &apos;obsolete class&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004819</classIRI>
<classLabel>resistin measurement</classLabel>
<deletedAxiom>&apos;resistin measurement&apos; SubClassOf &apos;autoimmune disease biomarker&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004733</classIRI>
<classLabel>anti-cyclic citrullinated peptide antibody measurement</classLabel>
<newAxiom>&apos;anti-cyclic citrullinated peptide antibody measurement&apos; SubClassOf &apos;protein measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004728</classIRI>
<classLabel>serum amyloid A protein measurement</classLabel>
<deletedAxiom>&apos;serum amyloid A protein measurement&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004762</classIRI>
<classLabel>vascular endothelial growth factor measurement</classLabel>
<newAxiom>&apos;vascular endothelial growth factor measurement&apos; SubClassOf &apos;cancer biomarker measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004769</classIRI>
<classLabel>anti-Mullerian hormone measurement</classLabel>
<newAxiom>&apos;anti-Mullerian hormone measurement&apos; SubClassOf &apos;protein measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005941</classIRI>
<classLabel>mammographic density measurement</classLabel>
<deletedAxiom>&apos;mammographic density measurement&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
<newAxiom>&apos;mammographic density measurement&apos; SubClassOf &apos;measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061477</classIRI>
<classLabel>response to aromatase inhibitor</classLabel>
<deletedAxiom>&apos;response to aromatase inhibitor&apos; SubClassOf &apos;response to drug&apos;</deletedAxiom>
<newAxiom>&apos;response to aromatase inhibitor&apos; SubClassOf &apos;response to endocrine therapy&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004993</classIRI>
<classLabel>serum IgM measurement</classLabel>
<deletedAxiom>&apos;serum IgM measurement&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
<newAxiom>&apos;serum IgM measurement&apos; SubClassOf &apos;measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004846</classIRI>
<classLabel>serotonin measurement</classLabel>
<deletedAxiom>&apos;serotonin measurement&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/EFO_0000796</classIRI>
<classLabel>obsolete_animal fluid</classLabel>
<deletedAxiom>&apos;obsolete_animal fluid&apos; SubClassOf &apos;obsolete class&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005298</classIRI>
<classLabel>allergic sensitization measurement</classLabel>
<deletedAxiom>&apos;allergic sensitization measurement&apos; SubClassOf &apos;measurement&apos;</deletedAxiom>
<newAxiom>&apos;allergic sensitization measurement&apos; SubClassOf &apos;allergy measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005132</classIRI>
<classLabel>5-HIAA measurement</classLabel>
<newAxiom>&apos;5-HIAA measurement&apos; SubClassOf &apos;metabolite measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005191</classIRI>
<classLabel>waist height ratio</classLabel>
<deletedAxiom>&apos;waist height ratio&apos; SubClassOf &apos;measurement&apos;</deletedAxiom>
<newAxiom>&apos;waist height ratio&apos; SubClassOf &apos;body weights and measures&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0007780</classIRI>
<classLabel>anti-citrullinated protein antibody seropositivity</classLabel>
<deletedAxiom>&apos;anti-citrullinated protein antibody seropositivity&apos; SubClassOf &apos;seropositivity measurement&apos;</deletedAxiom>
<newAxiom>&apos;anti-citrullinated protein antibody seropositivity&apos; SubClassOf &apos;measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005413</classIRI>
<classLabel>joint damage measurement</classLabel>
<deletedAxiom>&apos;joint damage measurement&apos; SubClassOf &apos;autoimmune disease biomarker&apos;</deletedAxiom>
<newAxiom>&apos;joint damage measurement&apos; SubClassOf &apos;measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0006900</classIRI>
<classLabel>endothelial growth factor measurement</classLabel>
<deletedAxiom>&apos;endothelial growth factor measurement&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0006953</classIRI>
<classLabel>family history of lung cancer</classLabel>
<deletedAxiom>&apos;family history of lung cancer&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0006955</classIRI>
<classLabel>ADAMTS13 activity measurement</classLabel>
<deletedAxiom>&apos;ADAMTS13 activity measurement&apos; SubClassOf &apos;measurement&apos;</deletedAxiom>
<newAxiom>&apos;ADAMTS13 activity measurement&apos; SubClassOf &apos;protein measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0006999</classIRI>
<classLabel>cancer aggressiveness measurement</classLabel>
<deletedAxiom>&apos;cancer aggressiveness measurement&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
<newAxiom>&apos;cancer aggressiveness measurement&apos; SubClassOf &apos;measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005512</classIRI>
<classLabel>estrogen receptor status</classLabel>
<deletedAxiom>&apos;estrogen receptor status&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
<newAxiom>&apos;estrogen receptor status&apos; SubClassOf &apos;measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005513</classIRI>
<classLabel>progesterone receptor status</classLabel>
<deletedAxiom>&apos;progesterone receptor status&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
<newAxiom>&apos;progesterone receptor status&apos; SubClassOf &apos;measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005514</classIRI>
<classLabel>HER2 status</classLabel>
<deletedAxiom>&apos;HER2 status&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
<newAxiom>&apos;HER2 status&apos; SubClassOf &apos;measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0006898</classIRI>
<classLabel>airway wall thickness measurement</classLabel>
<deletedAxiom>&apos;airway wall thickness measurement&apos; SubClassOf &apos;measurement&apos;</deletedAxiom>
<newAxiom>&apos;airway wall thickness measurement&apos; SubClassOf &apos;pulmonary function measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005581</classIRI>
<classLabel>red-green color blindness</classLabel>
<deletedAxiom>&apos;red-green color blindness&apos; SubClassOf &apos;genetic disorder&apos;</deletedAxiom>
<newAxiom>&apos;red-green color blindness&apos; SubClassOf &apos;Color-vision disease&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005580</classIRI>
<classLabel>red color blindness</classLabel>
<deletedAxiom>&apos;red color blindness&apos; SubClassOf &apos;genetic disorder&apos;</deletedAxiom>
<deletedAxiom>&apos;red color blindness&apos; SubClassOf &apos;eye disease&apos;</deletedAxiom>
<newAxiom>&apos;red color blindness&apos; SubClassOf &apos;Color-vision disease&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004518</classIRI>
<classLabel>serum creatinine measurement</classLabel>
<newAxiom>&apos;serum creatinine measurement&apos; SubClassOf &apos;metabolite measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004502</classIRI>
<classLabel>adiponectin measurement</classLabel>
<newAxiom>&apos;adiponectin measurement&apos; SubClassOf &apos;protein measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004587</classIRI>
<classLabel>lymphocyte count</classLabel>
<deletedAxiom>&apos;lymphocyte count&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0005761</classIRI>
<classLabel>lupus nephritis</classLabel>
<deletedAxiom>&apos;lupus nephritis&apos; SubClassOf &apos;autoimmune disease biomarker&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004459</classIRI>
<classLabel>ferritin measurement</classLabel>
<deletedAxiom>&apos;ferritin measurement&apos; SubClassOf &apos;measurement&apos;</deletedAxiom>
<newAxiom>&apos;ferritin measurement&apos; SubClassOf &apos;iron biomarker measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0004463</classIRI>
<classLabel>angiotensin converting enzyme activity measurement</classLabel>
<deletedAxiom>&apos;angiotensin converting enzyme activity measurement&apos; SubClassOf &apos;measurement&apos;</deletedAxiom>
<newAxiom>&apos;angiotensin converting enzyme activity measurement&apos; SubClassOf &apos;protein measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0007001</classIRI>
<classLabel>dehydroepiandrosterone sulphate measurement</classLabel>
<newAxiom>&apos;dehydroepiandrosterone sulphate measurement&apos; SubClassOf &apos;metabolite measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0007000</classIRI>
<classLabel>Gleason score measurement</classLabel>
<deletedAxiom>&apos;Gleason score measurement&apos; SubClassOf &apos;cancer biomarker measurement&apos;</deletedAxiom>
<newAxiom>&apos;Gleason score measurement&apos; SubClassOf &apos;measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0007020</classIRI>
<classLabel>AR-C124910XX measurement</classLabel>
<deletedAxiom>&apos;AR-C124910XX measurement&apos; SubClassOf &apos;measurement&apos;</deletedAxiom>
<newAxiom>&apos;AR-C124910XX measurement&apos; SubClassOf &apos;metabolite measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0007015</classIRI>
<classLabel>3-hydroxy-1-methylpropylmercapturic acid measurement</classLabel>
<deletedAxiom>&apos;3-hydroxy-1-methylpropylmercapturic acid measurement&apos; SubClassOf &apos;measurement&apos;</deletedAxiom>
<newAxiom>&apos;3-hydroxy-1-methylpropylmercapturic acid measurement&apos; SubClassOf &apos;urinary metabolite measurement&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/HP_0005521</classIRI>
<classLabel>disseminated intravascular coagulation</classLabel>
<deletedAxiom>&apos;disseminated intravascular coagulation&apos; SubClassOf &apos;abnormality of blood and blood-forming tissues&apos;</deletedAxiom>
<newAxiom>&apos;disseminated intravascular coagulation&apos; SubClassOf http://purl.obolibrary.org/obo/HP_0001977</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0007613</classIRI>
<classLabel>response to endocrine therapy</classLabel>
<deletedAxiom>&apos;response to endocrine therapy&apos; SubClassOf &apos;response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;response to endocrine therapy&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_1001507</classIRI>
<classLabel>asparaginase-induced acute pancreatitis</classLabel>
<newAxiom>'asparaginase-induced acute pancreatitis' SubClassOf 'acute pancreatitis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_1001506</classIRI>
<classLabel>primary angle closure glaucoma</classLabel>
<newAxiom>'primary angle closure glaucoma' SubClassOf 'glaucoma'</newAxiom>
</newClass>
<newClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_1001505</classIRI>
<classLabel>cystic liver disease</classLabel>
<newAxiom>'cystic liver disease' SubClassOf 'liver disease'</newAxiom>
</newClass>
<newClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_1001504</classIRI>
<classLabel>small vessel stroke</classLabel>
<newAxiom>'small vessel stroke' SubClassOf 'stroke'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/HP_0004354</classIRI>
<classLabel>Abnormality of carboxylic acid metabolism</classLabel>
<newAxiom>'Abnormality of carboxylic acid metabolism' SubClassOf 'abnormality of metabolism/homeostasis'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/HP_0003150</classIRI>
<classLabel>Glutaric aciduria</classLabel>
<newAxiom>'Glutaric aciduria' SubClassOf 'Abnormality of carboxylic acid metabolism'</newAxiom>
</newClass>
<newClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0000796</classIRI>
<classLabel>obsolete_animal fluid</classLabel>
<newAxiom>'obsolete_animal fluid' SubClassOf 'obsolete class'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/HP_0000359</classIRI>
<classLabel>Abnormality of the inner ear</classLabel>
<newAxiom>'Abnormality of the inner ear' SubClassOf 'Abnormality of the ear'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/HP_0000639</classIRI>
<classLabel>Nystagmus</classLabel>
<newAxiom>'Nystagmus' SubClassOf 'Abnormality of the inner ear'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/HP_0001977</classIRI>
<classLabel>Abnormal thrombosis</classLabel>
<newAxiom>'Abnormal thrombosis' SubClassOf 'abnormality of blood and blood-forming tissues'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/UBERON_0000914</classIRI>
<classLabel>organismal segment</classLabel>
<newAxiom>'organismal segment' SubClassOf 'animal component'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/UBERON_0000982</classIRI>
<classLabel>skeletal joint</classLabel>
<newAxiom>'skeletal joint' SubClassOf 'skeleton structure'</newAxiom>
</newClass>
<newClass>
<classIRI>http://www.ebi.ac.uk/efo/EFO_0007781</classIRI>
<classLabel>stressful life event measurement</classLabel>
<newAxiom>'stressful life event measurement' SubClassOf 'mental or behavioural disorder biomarker'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/HP_0030436</classIRI>
<classLabel>Fibrofolliculoma</classLabel>
<newAxiom>'Fibrofolliculoma' SubClassOf 'abnormality of the skin'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
<deletedClass>
<classIRI>http://purl.obolibrary.org/obo/EFO_0000796</classIRI>
<classLabel>obsolete_animal fluid</classLabel>
<newAxiom>'obsolete_animal fluid' SubClassOf 'obsolete class'</newAxiom>
</deletedClass>
</deletedClasses>
</diffReport>